| # Pan-Hematopoiesis PANDA | |
| Multi-dataset HSC + hematopoietic lineage corpus for cell identity + zero-shot transfer + | |
| mechanistic discovery. | |
| ## Corpus datasets | |
| | Accession | Study | Cells | Species | Modality | Role | | |
| |---|---|---:|---|---|---| | |
| | GSE140802 | Weinreb LARRY 2020 | 75,339 | mouse | 10x + clonal barcodes | Anchor (local) | | |
| | GSE72857 | Paul 2015 | ~10,000 | mouse | MARS-seq | Foundational myeloid branch reference | | |
| | GSE81682 | Nestorowa 2016 | ~1,656 | mouse | Smart-seq2 | FACS-index-sorted HSPC anchor | | |
| | GSE89754 | Tusi 2018 | ~4,763 | mouse | inDrops | Erythroid trajectory + PBA fate probs | | |
| | GSE107727 | Dahlin 2018 | ~44,802 | mouse | 10x | Large LSK/Kit+ landscape + Kit-mutant contrast | | |
| ## Held-out labeled validation | |
| **Nestorowa 2016 index-sort labels** — held-out from training and evaluated with the | |
| FACS-index-sorted ground truth (LT-HSC / MPP / GMP / MEP / CLP) which is orthogonal to | |
| mRNA. Provides a clean cross-lab / cross-platform accuracy measurement. | |
| ## Held-out unlabeled discovery target | |
| **Dahlin 2018 W41-mutant subset** — subset of GSE107727 where Kit-mutant hematopoiesis is | |
| stress-tested. Weakly labeled; PANDA predictions probe how mutation shifts the identity | |
| distribution. | |
| ## Ontology (10 classes) | |
| - LT-HSC | |
| - MPP (multipotent progenitor) | |
| - CMP (common myeloid progenitor) | |
| - MEP (megakaryocyte-erythroid progenitor) | |
| - GMP (granulocyte-monocyte progenitor) | |
| - erythroid | |
| - myeloid (Neu + Mono + DC merged) | |
| - lymphoid (B/T/NK) | |
| - megakaryocyte | |
| - basophil-mast | |