tools/citation_gap_queue.md

Citation-gap discovery queue (2026-08-05)

Papers cited >=8 times by the 291-PMID challenge pool that appear in ZERO submissions.

Built by pulling every pool paper's reference list from the Semantic Scholar batch endpoint (17411 reference edges over 288 papers), counting external references, then filtering to primary research (PubMed pubtype excluding Review and Meta-Analysis) and scoring each title against the endpoint vocabulary of the five hypotheses.

Reproduce: POST https://api.semanticscholar.org/graph/v1/paper/batch ids=["PMID:"], fields=references.externalIds,references.title

score	pool cites	PMID	year	title
9	15	33831349	2021	Selective removal of astrocytic APOE4 strongly protects against tau-mediated neurodege
8	19	30791549	2019	Apolipoprotein E4 Alters Astrocyte Fatty Acid Metabolism and Lipid Droplet Formation.
7	17	21715678	2011	Human apoE isoforms differentially regulate brain amyloid-β peptide clearance.
7	10	33556209	2021	Expression and secretion of apoE isoforms in astrocytes and microglia during inflammat
7	8	29946028	2018	Amyloid clearance defect in ApoE4 astrocytes is reversed by epigenetic correction of e
6	9	27567858	2016	ABCA1 Agonist Reverses the ApoE4-Driven Cognitive and Brain Pathologies.
5	43	29953873	2018	APOE4 Causes Widespread Molecular and Cellular Alterations Associated with Alzheimer's
5	11	9218423	1997	Targeted replacement of the mouse apolipoprotein E gene with the common human APOE3 al
5	11	34424266	2021	TREM2-dependent lipid droplet biogenesis in phagocytes is required for remyelination.
5	11	22289388	2012	Dynamics and regulation of lipid droplet formation in lipopolysaccharide (LPS)-stimula
5	9	29632371	2018	Gain of toxic apolipoprotein E4 effects in human iPSC-derived neurons is ameliorated b
5	9	19474305	2009	Human APOE isoform-dependent effects on brain beta-amyloid levels in PDAPP transgenic
5	9	19033669	2008	apoE isoform-specific disruption of amyloid beta peptide clearance from mouse brain.
4	23	31902528	2020	TREM2 Regulates Microglial Cholesterol Metabolism upon Chronic Phagocytic Challenge.
4	14	30577865	2018	Development and validation of a simplified method to generate human microglia from plu
4	14	27477018	2016	TREM2 Binds to Apolipoproteins, Including APOE and CLU/APOJ, and Thereby Facilitates U
4	13	28426964	2017	iPSC-Derived Human Microglia-like Cells to Study Neurological Diseases.
4	12	33257666	2020	Single cell RNA sequencing of human microglia uncovers a subset associated with Alzhei
4	12	29416036	2018	A transcriptomic atlas of aged human microglia.
4	11	37774678	2023	Human microglial state dynamics in Alzheimer's disease progression.
4	11	32514138	2020	Alzheimer's-associated PLCγ2 is a signaling node required for both TREM2 function and
4	11	28444230	2017	APOE ε4/ε4 diminishes neurotrophic function of human iPSC-derived astrocytes.
4	9	28546318	2017	An environment-dependent transcriptional network specifies human microglia identity.
4	8	34021136	2021	Transcriptional signature in microglia associated with Aβ plaque phagocytosis.
4	8	31375314	2019	Development of a Chimeric Model to Study and Manipulate Human Microglia In Vivo.
4	8	28757165	2017	An Efficient Platform for Astrocyte Differentiation from Human Induced Pluripotent Ste
4	8	18701698	2008	Microglial dysfunction and defective beta-amyloid clearance pathways in aging Alzheime
4	8	10514484	1999	Unique lipoproteins secreted by primary astrocytes from wild type, apoE (-/-), and hum

Extracted by k-dense so far: 30791549 (M3H2), 27567858 (M1H2). The rest are unclaimed. Score is a title-vocabulary heuristic, not a relevance judgement - read the abstract before extracting.