tools/citation_gap_queue.md

# Citation-gap discovery queue (2026-08-05)

Papers cited >=8 times by the 291-PMID challenge pool that appear in ZERO submissions.

Built by pulling every pool paper's reference list from the Semantic Scholar batch endpoint
(17411 reference edges over 288 papers), counting external references, then filtering to
primary research (PubMed pubtype excluding Review and Meta-Analysis) and scoring each title
against the endpoint vocabulary of the five hypotheses.

Reproduce: POST https://api.semanticscholar.org/graph/v1/paper/batch
           ids=["PMID:<each pool pmid>"], fields=references.externalIds,references.title

| score | pool cites | PMID | year | title |
|---|---|---|---|---|
| 9 | 15 | 33831349 | 2021 | Selective removal of astrocytic APOE4 strongly protects against tau-mediated neurodege |
| 8 | 19 | 30791549 | 2019 | Apolipoprotein E4 Alters Astrocyte Fatty Acid Metabolism and Lipid Droplet Formation. |
| 7 | 17 | 21715678 | 2011 | Human apoE isoforms differentially regulate brain amyloid-β peptide clearance. |
| 7 | 10 | 33556209 | 2021 | Expression and secretion of apoE isoforms in astrocytes and microglia during inflammat |
| 7 | 8 | 29946028 | 2018 | Amyloid clearance defect in ApoE4 astrocytes is reversed by epigenetic correction of e |
| 6 | 9 | 27567858 | 2016 | ABCA1 Agonist Reverses the ApoE4-Driven Cognitive and Brain Pathologies. |
| 5 | 43 | 29953873 | 2018 | APOE4 Causes Widespread Molecular and Cellular Alterations Associated with Alzheimer's |
| 5 | 11 | 9218423 | 1997 | Targeted replacement of the mouse apolipoprotein E gene with the common human APOE3 al |
| 5 | 11 | 34424266 | 2021 | TREM2-dependent lipid droplet biogenesis in phagocytes is required for remyelination. |
| 5 | 11 | 22289388 | 2012 | Dynamics and regulation of lipid droplet formation in lipopolysaccharide (LPS)-stimula |
| 5 | 9 | 29632371 | 2018 | Gain of toxic apolipoprotein E4 effects in human iPSC-derived neurons is ameliorated b |
| 5 | 9 | 19474305 | 2009 | Human APOE isoform-dependent effects on brain beta-amyloid levels in PDAPP transgenic  |
| 5 | 9 | 19033669 | 2008 | apoE isoform-specific disruption of amyloid beta peptide clearance from mouse brain. |
| 4 | 23 | 31902528 | 2020 | TREM2 Regulates Microglial Cholesterol Metabolism upon Chronic Phagocytic Challenge. |
| 4 | 14 | 30577865 | 2018 | Development and validation of a simplified method to generate human microglia from plu |
| 4 | 14 | 27477018 | 2016 | TREM2 Binds to Apolipoproteins, Including APOE and CLU/APOJ, and Thereby Facilitates U |
| 4 | 13 | 28426964 | 2017 | iPSC-Derived Human Microglia-like Cells to Study Neurological Diseases. |
| 4 | 12 | 33257666 | 2020 | Single cell RNA sequencing of human microglia uncovers a subset associated with Alzhei |
| 4 | 12 | 29416036 | 2018 | A transcriptomic atlas of aged human microglia. |
| 4 | 11 | 37774678 | 2023 | Human microglial state dynamics in Alzheimer's disease progression. |
| 4 | 11 | 32514138 | 2020 | Alzheimer's-associated PLCγ2 is a signaling node required for both TREM2 function and  |
| 4 | 11 | 28444230 | 2017 | APOE ε4/ε4 diminishes neurotrophic function of human iPSC-derived astrocytes. |
| 4 | 9 | 28546318 | 2017 | An environment-dependent transcriptional network specifies human microglia identity. |
| 4 | 8 | 34021136 | 2021 | Transcriptional signature in microglia associated with Aβ plaque phagocytosis. |
| 4 | 8 | 31375314 | 2019 | Development of a Chimeric Model to Study and Manipulate Human Microglia In Vivo. |
| 4 | 8 | 28757165 | 2017 | An Efficient Platform for Astrocyte Differentiation from Human Induced Pluripotent Ste |
| 4 | 8 | 18701698 | 2008 | Microglial dysfunction and defective beta-amyloid clearance pathways in aging Alzheime |
| 4 | 8 | 10514484 | 1999 | Unique lipoproteins secreted by primary astrocytes from wild type, apoE (-/-), and hum |

Extracted by k-dense so far: 30791549 (M3H2), 27567858 (M1H2).
The rest are unclaimed. Score is a title-vocabulary heuristic, not a relevance judgement -
read the abstract before extracting.