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AdapterOcean
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med_alpaca_standardized_cluster_91_std

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Please summerize the given abstract to a title
instruction
0
895,501
91
2,686,018
Multicenter interim guidance on use of antivirals for children with COVID-19/SARS-CoV-2
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1
895,501
91
2,686,019
BACKGROUND: Although Coronavirus Disease 2019 (COVID-19) is a mild infection in most children, a small proportion develop severe or critical illness. Data evaluating agents with potential antiviral activity continue to expand, such that updated guidance is needed regarding use of these agents in children. METHODS: A pa...
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2
895,501
91
2,686,020
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0
895,652
91
2,686,471
Safety of anti-CGRP monoclonal antibodies in patients with migraine during the COVID-19 pandemic: present and future implications
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1
895,652
91
2,686,472
Background and objective: CGRP, a neuropeptide involved in migraine pathophysiology, is also known to play a role in the respiratory system and in such immunological conditions as sepsis. We analysed the impact of the use of CGRP antagonists in patients with migraine during the COVID-19 pandemic, caused by the SARS-CoV...
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2
895,652
91
2,686,473
Please summerize the given abstract to a title
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0
895,768
91
2,686,819
ReumaCoV Brasil Registry: a Brazilian cohort of Patients with Immuno-mediated Chronic Inflammatory Diseases Infected by SARS-CoV-2
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1
895,768
91
2,686,820
BACKGROUND: Patients with immune-mediated rheumatic diseases (IMRD) are at increased risk of infections, including significant morbidity and high mortality Considering the potential for unfavorable outcomes of SARS-CoV-2 infection in patients with IMRD, several questions were released regarding the impact of COVID-19 i...
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2
895,768
91
2,686,821
Please summerize the given abstract to a title
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0
895,875
91
2,687,140
COVID-19 in heart transplant patients: Case reports from Brazil
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1
895,875
91
2,687,141
INTRODUCTION: The COVID-19 pandemic continues, with a late hyperinflammatory phase. The immunosuppressive therapy used in heart transplant patients, in theory, could reduce inflammation thus benefitting patients with COVID-19. So far, however, there is still very little literature on this subject. METHODS: This is a si...
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2
895,875
91
2,687,142
Please summerize the given abstract to a title
instruction
0
895,882
91
2,687,161
The effectiveness of high-dose intravenous vitamin C for patients with coronavirus disease 2019: A systematic review and meta-analysis
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1
895,882
91
2,687,162
OBJECTIVES: Vitamin C has anti-inflammatory effects. This review aimed to investigate the therapeutic effect of high-dose intravenous vitamin C (HDIVC) in patients with coronavirus disease 2019 (COVID-19). METHODS: The following key phrases were searched for article inclusion: “Vitamin C OR ascorbic acid” AND “COVID-19...
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2
895,882
91
2,687,163
Please summerize the given abstract to a title
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0
895,915
91
2,687,260
Lopinavir/ritonavir and interferon combination therapy may help shorten the duration of viral shedding in patients with COVID-19: A retrospective study in two designated hospitals in Anhui, China
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1
895,915
91
2,687,261
Prolonged viral shedding may pose a threat to the control of coronavirus disease-2019 (COVID-19), and data on the duration of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) shedding are still limited, with the associated factors being unknown. All adult patients with laboratory-confirmed COVID-19 were inc...
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2
895,915
91
2,687,262
Please summerize the given abstract to a title
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0
895,946
91
2,687,353
Anti Xa activity after high dose LMWH thrombosis prophylaxis in covid 19 patients at the intensive care unit
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1
895,946
91
2,687,354
INTRODUCTION: Coagulopathy in Coronavirus disease 2019 (covid-19) has been demonstrated by an increase in D-dimer, prothrombin time (PT), fibrinogen and factor VIII. Venous thromboembolic events are a common abnormality in patients with covid-19. We evaluate the results of intensive care unit (ICU) thrombosis prophylax...
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2
895,946
91
2,687,355
Please summerize the given abstract to a title
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0
896,183
91
2,688,064
The Effect of Probiotics on Respiratory Tract Infection with Special Emphasis on COVID-19: A Periodic Review during 2010-2020
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1
896,183
91
2,688,065
To evaluate the effects of probiotic on patient’s respiratory tract infection (RTI), a systematic review was conducted on randomized controlled trials (RCTs). PubMed, Google Scholar, Embase, Scopus, Clinicaltrials.gov, and International Clinical Trials Registry Platform (ICTRP) databases were systematically searched fo...
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2
896,183
91
2,688,066
Please summerize the given abstract to a title
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0
896,208
91
2,688,139
Convalescent plasma or hyperimmune immunoglobulin for people with COVID-19: a living systematic review.
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1
896,208
91
2,688,140
BACKGROUND Convalescent plasma and hyperimmune immunoglobulin may reduce mortality in patients with viral respiratory diseases, and are currently being investigated in trials as potential therapy for coronavirus disease 2019 (COVID-19). A thorough understanding of the current body of evidence regarding the benefits and...
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2
896,208
91
2,688,141
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0
896,221
91
2,688,178
Fr501 BIOLOGICS AND COVID-19 OUTCOMES IN INFLAMMATORY BOWEL DISEASE PATIENTS
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1
896,221
91
2,688,179
Introduction Both clinicians and inflammatory bowel disease (IBD) patients remain concernedthat either their disease or medications—namely biologics, may increase the risk ofsevere adverse outcomes from coronavirus disease-2019 (COVID-19). We performed a systematic review and meta-analysis of the available literature t...
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2
896,221
91
2,688,180
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0
896,247
91
2,688,256
Efficacy of Tocilizumab in Patients with a Moderate and Severe COVID-19: A Retrospective Single Center Cohort Study
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1
896,247
91
2,688,257
Introduction: Interleukin-6 (IL-6) is the key cytokine in "cytokine release syndrome" and associated with the lung fibrosis. Tocilizumab (TCZ) reduces the negative effects of inflammation by blocking the binding of IL-6 to its receptor. Materials and Methods: This was a retrospective observational cohort study. Patient...
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2
896,247
91
2,688,258
Please summerize the given abstract to a title
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0
896,261
91
2,688,298
Treatment of Severe Acute Respiratory Syndrome With Glucosteroids: The Guangzhou Experience
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1
896,261
91
2,688,299
STUDY OBJECTIVE: To investigate the efficacy and safety profiles of corticosteroid therapy in severe acute respiratory syndrome (SARS) patients. DESIGN: Four hundred one of 1,278 SARS cases treated in Guangzhou China between December 2002 and June 2003 fulfilled the diagnostic criteria issued by the World Health Organi...
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2
896,261
91
2,688,300
Please summerize the given abstract to a title
instruction
0
896,296
91
2,688,403
Evaluation of safety, efficacy, tolerability, and treatment-related outcomes of type I interferons for Human coronaviruses (HCoVs) infection in clinical practice: An updated critical systematic review and meta-analysis
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1
896,296
91
2,688,404
BACKGROUND: There is no vaccine or specific antiviral treatment for HCoVs infection. The use of type I interferons for coronavirus is still under great debate in clinical practice. MATERIALS AND METHODS: A literature search of all relevant studies published on PubMed, Cochrane library, Web of Science database, Science ...
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2
896,296
91
2,688,405
Please summerize the given abstract to a title
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0
896,446
91
2,688,853
Impact of anti-androgenic therapies on COVID-19: an observational study in male population from a COVID-19 regional centre of Lombardy (Italy)
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1
896,446
91
2,688,854
Importance: There are gender differences in vulnerability to the Coronavirus disease 2019 (COVID-19), with men experiencing more severe disease at any age. The use of anti-androgen drugs, like 5-alpha reductase inhibitors (5ARIs), could protect from severe pulmonary disease. Objective: To determine whether men who rece...
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2
896,446
91
2,688,855
Please summerize the given abstract to a title
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0
896,521
91
2,689,078
Drug-Related Pneumonitis in Cancer Treatment during the COVID-19 Era
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1
896,521
91
2,689,079
Interstitial lung disease is recognized as a group of diseases with a different etiopathogenesis characterized by chronic lung inflammation with the accumulation of inflammatory cells, lymphocytes and macrophages, and the consequent release of proinflammatory cytokines. Various degrees of pulmonary fibrosis can be asso...
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2
896,521
91
2,689,080
Please summerize the given abstract to a title
instruction
0
896,565
91
2,689,210
6ER-028 Baricitinib against severe COVID-19: effectiveness and safety in hospital care
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1
896,565
91
2,689,211
Background and importanceBaricitinib has recently been used off-label for COVID-19 because of its potential role in reducing systemic inflammation, lung damage, immune response and viral endocytosis based on preclinical data Aim and objectivesTo analyse the effectiveness and safety of baricitinib for severe COVID-19 in...
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2
896,565
91
2,689,212
Please summerize the given abstract to a title
instruction
0
896,761
91
2,689,798
Ivermectin for Prevention and Treatment of COVID-19 Infection: A Systematic Review, Meta-analysis, and Trial Sequential Analysis to Inform Clinical Guidelines
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1
896,761
91
2,689,799
Repurposed medicines may have a role against the SARS-CoV-2 virus. The antiparasitic ivermectin, with antiviral and anti-inflammatory properties, has now been tested in numerous clinical trials. AREAS OF UNCERTAINTY: We assessed the efficacy of ivermectin treatment in reducing mortality, in secondary outcomes, and in c...
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2
896,761
91
2,689,800
Please summerize the given abstract to a title
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0
896,947
91
2,690,356
CytoSorb® Hemoadsorption as a Promising Tool to Handle COVID-19-Induced Cytokine Storm
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1
896,947
91
2,690,357
Accumulating evidence suggests that a patient subgroup with severe COVID-19 develops a cytokine release syndrome leading to capillary leakage and organ injury. Recent publications addressing therapy of cytokine storms recommended new extracorporeal therapies such as hemoadsorption. This case report describes a 59-year-...
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2
896,947
91
2,690,358
Please summerize the given abstract to a title
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0
896,948
91
2,690,359
Eosinophilia is associated with improved COVID-19 outcomes in inhaled corticosteroids-treated patients.
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1
896,948
91
2,690,360
Background In addition to their proinflammatory effect, eosinophils have anti-viral properties. Similarly, inhaled corticosteroids (iCS) were found to suppress coronavirus replication in-vitro and were associated with improved outcomes in coronavirus disease 2019 (COVID-19). However, the interplay between the two and i...
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2
896,948
91
2,690,361
Please summerize the given abstract to a title
instruction
0
897,085
91
2,690,770
Successful Management of COVID-19 Infection in 2 Early Post-Liver Transplant Recipients
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1
897,085
91
2,690,771
BACKGROUND: Coronavirus disease 2019 (COVID-19) has affected all facets of life and continues to cripple nations. COVID-19 has taken the lives of more than 2.1 million people worldwide, with a global mortality rate of 2.2%. Current COVID-19 treatment options include supportive respiratory care, parenteral corticosteroi...
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2
897,085
91
2,690,772
Please summerize the given abstract to a title
instruction
0
897,103
91
2,690,824
Intermittent Hypoxic Preconditioning: A Potential New Powerful Strategy for COVID-19 Rehabilitation
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1
897,103
91
2,690,825
COVID-19 is a highly infectious respiratory virus, which can proliferate by invading the ACE2 receptor of host cells. Clinical studies have found that the virus can cause dyspnea, pneumonia and other cardiopulmonary system damage. In severe cases, it can lead to respiratory failure and even death. Although there are cu...
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2
897,103
91
2,690,826
Please summerize the given abstract to a title
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0
897,148
91
2,690,959
Tocilizumab in the treatment of critical COVID-19 pneumonia
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1
897,148
91
2,690,960
Background: The anti-interleukin-6 receptor monoclonal antibody tocilizumab has been proposed as a treatment for COVID-19 pneumonia although the efficacy remains unknown Methods: Patients with COVID-19 confirmed by nasal swab PCR for SARSCoV- 2 who were admitted to Stony Brook University Hospital in Suffolk County, New...
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2
897,148
91
2,690,961
Please summerize the given abstract to a title
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0
897,370
91
2,691,625
Impact of rituximab on COVID-19 outcomes
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1
897,370
91
2,691,626
Rituximab is associated with prolonged B-cell depletion and secondary hypogammaglobulinemia and is associated with a dampened humoral response and increased infectious complications. To describe the potential impact of prior rituximab therapy on clinical outcomes from SARS-CoV-2 infection and development of COVID-19 an...
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2
897,370
91
2,691,627
Please summerize the given abstract to a title
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0
897,489
91
2,691,982
Infusion of HLA-matched and static magnetic field-exposed allogenic lymphocytes treating lymphocytopenia and cytokine storm syndrome: A treatment proposal for COVID-19 patients.
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1
897,489
91
2,691,983
Among haematological parameters of patients seriously ill with the coronavirus infectious disease 2019 (COVID-19), leucocytosis, lymphocytopenia, and the abnormal release of circulating cytokines, termed cytokine storm syndrome (CSS, also known as cytokine release syndrome or CRS), were found associated with disease se...
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2
897,489
91
2,691,984
Please summerize the given abstract to a title
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0
897,729
91
2,692,702
Personalized prescription of ACEI/ARBs for hypertensive COVID-19 patients
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1
897,729
91
2,692,703
The COVID-19 pandemic has prompted an international effort to develop and repurpose medications and procedures to effectively combat the disease. Several groups have focused on the potential treatment utility of angiotensin-converting-enzyme inhibitors (ACEIs) and angiotensin-receptor blockers (ARBs) for hypertensive C...
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2
897,729
91
2,692,704
Please summerize the given abstract to a title
instruction
0
897,766
91
2,692,813
Clinical efficacy of Methylprednisolone and the combined use of Lopinavir/Ritonavir with Arbidol in treatment of Coronavirus Disease 2019
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1
897,766
91
2,692,814
OBJECTIVE: This study aims to comparatively analyze the therapeutic efficacy upon multiple medication plans over Lopinavir/Ritonavir (LPV/r), Arbidol (ARB) and Methylprednisolone on patients with Coronavirus Disease 2019 (COVID‐19). METHODS: Totally 75 COVID‐19 patients admitted to The First Affiliated Hospital, Zhejia...
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2
897,766
91
2,692,815
Please summerize the given abstract to a title
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0
897,805
91
2,692,930
Randomized Clinical Trial to Evaluate a Routine Full Anticoagulation Strategy in Patients with Coronavirus Infection (SARS-CoV2) Admitted to Hospital: Rationale and Design of the ACTION (AntiCoagulaTlon cOroNavirus)–Coalition IV Trial
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1
897,805
91
2,692,931
BACKGROUND: : Observational studies have suggested a higher risk of thrombotic events in patients with coronavirus disease 2019 (COVID-19). Moreover, elevated D-dimer levels have been identified as an important prognostic marker in COVID-19 directly associated with disease severity and progression. Prophylactic anticoa...
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2
897,805
91
2,692,932
Please summerize the given abstract to a title
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0
897,827
91
2,692,996
A systematic review and meta-analysis to evaluate the clinical outcomes in COVID-19 patients on angiotensin-converting enzyme inhibitors or angiotensin receptor blockers
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1
897,827
91
2,692,997
INTRODUCTION: Angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) share their target receptor site with the SARS-CoV-2 virus, that may cause ACE2 receptor up-regulation which raised concerns regarding ACEI and ARB use in COVID-19 patients. However, many medical professional societi...
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2
897,827
91
2,692,998
Please summerize the given abstract to a title
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0
897,879
91
2,693,152
563. Tocilizumab in the Treatment of Critical COVID-19 Pneumonia
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1
897,879
91
2,693,153
BACKGROUND: The anti-interleukin-6 receptor monoclonal antibody tocilizumab has been proposed as a treatment for COVID-19 pneumonia although the efficacy remains unknown. METHODS: Patients with COVID-19 confirmed by nasal swab PCR for SARS-CoV-2 who were admitted to Stony Brook University Hospital in Suffolk County, Ne...
input
2
897,879
91
2,693,154
Please summerize the given abstract to a title
instruction
0
897,905
91
2,693,230
Influence of recent administration and type of oncological treatment (T) in survival of oncological patients (p) with COVID-19: Experience of Vall d'Hebron University Hospital
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1
897,905
91
2,693,231
Background: SARS-CoV-2 outbreak has impacted on the management of oncological p, leading to treatment delays in a considerable number of cases The aim of this study was to evaluate if oncological T affected negatively COVID-19 outcome Methods: We retrospectively analyzed clinical data from p with solid tumors under act...
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2
897,905
91
2,693,232
Please summerize the given abstract to a title
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0
897,947
91
2,693,356
Clinical and economic benefits of lenzilumab plus standard of care compared with standard of care alone for the treatment of hospitalized patients with Coronavirus Disease 19 (COVID-19) from the perspective of National Health Service England
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1
897,947
91
2,693,357
Purpose: Estimate the clinical and economic benefits of lenzilumab plus standard of care (SOC) compared with SOC alone in the treatment of hospitalized COVID-19 patients from the National Health Service (NHS) England perspective. Methods: A cost calculator was developed to estimate the clinical benefits and costs of ad...
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2
897,947
91
2,693,358
Please summerize the given abstract to a title
instruction
0
897,969
91
2,693,422
Metformin therapy, severity and mortality of SARS-CoV-2 infection: A meta-analysis
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1
897,969
91
2,693,423
Background. It has been postulated that metformin could have anti-SARS-CoV-2 action. This raises the hypothesis that people who take metformin may have lower SARS-CoV-2 severity and/or mortality. Objectives. To conduct a meta-analysis of the association between the use of Metformin and risk of severity and mortality in...
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2
897,969
91
2,693,424
Please summerize the given abstract to a title
instruction
0
898,067
91
2,693,716
Corticosteroids Treatment for Patients With Coronavirus Disease-2019 (COVID-19) With Different Disease Severity: a Systematic Review and Meta-analysis Protocol
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1
898,067
91
2,693,717
Introduction: As the coronavirus disease 2019 (COVID-19) pandemic progresses, identifying effective antiviral agents to treat the COVID-19 is of most urgency. Efficacy and safety of corticosteroids in patients with COVID-19 still are debated. Because high-quality randomized clinical trials (RCTs) on the use of corticos...
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2
898,067
91
2,693,718