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In molecular biology, Small nucleolar RNA Z178 is a non-coding RNA (ncRNA) molecule which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA. snoRNA Z178 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs.Plant snoRNA Z178 was identified in a screen of Oryza sativa. | https://en.wikipedia.org/wiki/Small_nucleolar_RNA_Z178 |
In molecular biology, Small nucleolar RNA Z182 is a non-coding RNA (ncRNA) molecule which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA. snoRNA Z182 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs.Plant snoRNA Z182 was identified in a screen of Oryza sativa. | https://en.wikipedia.org/wiki/Small_nucleolar_RNA_Z182 |
In molecular biology, Small nucleolar RNA Z185 is a non-coding RNA (ncRNA) molecule which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA. snoRNA Z185 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs.Plant snoRNA Z185 was identified in a screen of Oryza sativa. | https://en.wikipedia.org/wiki/Small_nucleolar_RNA_Z185 |
In molecular biology, Small nucleolar RNA Z188 is a non-coding RNA (ncRNA) molecule which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA. snoRNA Z188 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs.Plant snoRNA Z188 was identified in a screen of Oryza sativa. | https://en.wikipedia.org/wiki/Small_nucleolar_RNA_Z188 |
In molecular biology, Small nucleolar RNA Z194 is a non-coding RNA (ncRNA) molecule which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA. snoRNA Z194 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs.Plant snoRNA Z194 was identified in a screen of Oryza sativa. | https://en.wikipedia.org/wiki/Small_nucleolar_RNA_Z194 |
In molecular biology, Small nucleolar RNA Z206 is a non-coding RNA (ncRNA) molecule which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA. snoRNA Z206 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs.Plant snoRNA Z206 was identified in a screen of Oryza sativa. | https://en.wikipedia.org/wiki/Small_nucleolar_RNA_Z206 |
In molecular biology, Small nucleolar RNA Z221 is a non-coding RNA (ncRNA) molecule which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA. snoRNA Z221 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs.Plant snoRNA Z221 was identified in a screen of Oryza sativa. | https://en.wikipedia.org/wiki/Small_nucleolar_RNA_Z221 |
In molecular biology, Small nucleolar RNA Z223 is a non-coding RNA (ncRNA) molecule which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA. snoRNA Z223 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs.Plant snoRNA Z223 was identified in a screen of Arabidopsis thaliana. | https://en.wikipedia.org/wiki/Small_nucleolar_RNA_Z223 |
In molecular biology, Small nucleolar RNA Z242 is a non-coding RNA (ncRNA) molecule which function in the biogenesis of other small nuclear RNAs (snRNAs). This small nucleolar RNA (snoRNA) is a modifying RNA and usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. snoRNA Z242 was identified in rice Oryza sativa, and is predicted to belong to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs. | https://en.wikipedia.org/wiki/Small_nucleolar_RNA_Z242 |
In molecular biology, Small nucleolar RNA Z247 is a non-coding RNA (ncRNA) molecule which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA. snoRNA Z247 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs.Plant snoRNA Z247 was identified in a screen of Oryza sativa. | https://en.wikipedia.org/wiki/Small_nucleolar_RNA_Z247 |
In molecular biology, Small nucleolar RNA Z256 is a non-coding RNA (ncRNA) molecule which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA. snoRNA Z256 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs.Plant snoRNA Z256 was identified in a screen of Oryza sativa. | https://en.wikipedia.org/wiki/Small_nucleolar_RNA_Z256 |
In molecular biology, Small nucleolar RNA Z266 is a non-coding RNA (ncRNA) molecule which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA. snoRNA Z266 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs.Plant snoRNA Z266 was identified in a screen of Oryza sativa. | https://en.wikipedia.org/wiki/Small_nucleolar_RNA_Z266 |
In molecular biology, Small nucleolar RNA Z267 is a non-coding RNA (ncRNA) molecule which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA. snoRNA Z267 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs.Plant snoRNA Z267 was identified in a screen of Oryza sativa. | https://en.wikipedia.org/wiki/Small_nucleolar_RNA_Z267 |
In molecular biology, Small nucleolar RNA Z278 is a non-coding RNA (ncRNA) molecule which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA. snoRNA Z278 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs.Plant snoRNA Z278 was identified in a screen of Oryza sativa. | https://en.wikipedia.org/wiki/Small_nucleolar_RNA_Z278 |
In molecular biology, Small nucleolar RNA Z279 is a non-coding RNA (ncRNA) molecule which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA. snoRNA Z279 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs.Plant snoRNA Z279 was identified in a screen of Oryza sativa. | https://en.wikipedia.org/wiki/Small_nucleolar_RNA_Z279 |
In molecular biology, Small nucleolar RNA Z39 is a non-coding RNA (ncRNA) molecule which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA. snoRNA Z39 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs.Plant snoRNA Z39 was identified in a screen of Oryza sativa. | https://en.wikipedia.org/wiki/Small_nucleolar_RNA_Z39 |
In molecular biology, Small nucleolar RNA Z40 is a non-coding RNA (ncRNA) molecule which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA. | https://en.wikipedia.org/wiki/Small_nucleolar_RNA_Z40 |
snoRNA Z40 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs. Plant snoRNA Z40 was identified in a screen of Oryza sativa. | https://en.wikipedia.org/wiki/Small_nucleolar_RNA_Z40 |
In molecular biology, Small nucleolar RNA Z43 is a non-coding RNA (ncRNA) molecule which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA. | https://en.wikipedia.org/wiki/Small_nucleolar_RNA_Z43 |
snoRNA Z43 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs. Plant snoRNA Z43 was identified in a screen of Oryza sativa. | https://en.wikipedia.org/wiki/Small_nucleolar_RNA_Z43 |
In molecular biology, Small nucleolar RNA Z50 is a non-coding RNA (ncRNA) molecule which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA. snoRNA Z50 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs.snoRNA Z50 was originally cloned from mouse brain tissues. | https://en.wikipedia.org/wiki/Small_nucleolar_RNA_Z50 |
In molecular biology, Small nucleolar RNA psi18S-1377 (also known as snoRNA psi28S-1377) is a non-coding RNA (ncRNA) molecule which functions in the biogenesis (modification) of other small nuclear RNAs (snRNAs). This type of modifying RNA is located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a 'guide RNA'. This Drosophila-specific snoRNA is a member of the H/ACA box class of snoRNA and is predicted to be responsible for guiding the modification of uridines 1377 and 1279 to pseudouridine in Drosophila 18S rRNA. | https://en.wikipedia.org/wiki/Small_nucleolar_RNA_psi18S-1377 |
In molecular biology, Small nucleolar RNA psi28S-1192 (also known as snoRNA psi28S-1192) is a non-coding RNA (ncRNA) molecule which functions in the biogenesis (modification) of other small nuclear RNAs (snRNAs). This type of modifying RNA is located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a 'guide RNA'. This Drosophila-specific snoRNA is a member of the H/ACA box class of snoRNA and is predicted to be responsible for guiding the modification of uridine 1192 to pseudouridine in Drosophila 28S rRNA. | https://en.wikipedia.org/wiki/Small_nucleolar_RNA_psi28S-1192 |
In molecular biology, Small nucleolar RNA psi28S-2876 (also known as snoRNA psi28S-2876) is a non-coding RNA (ncRNA) molecule which functions in the biogenesis (modification) of other small nuclear RNAs (snRNAs). This type of modifying RNA is located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a 'guide RNA'. This Drosophila-specific snoRNA is a member of the H/ACA box class of snoRNA and is predicted to be responsible for guiding the modification of uridines 2876 and 2956 to pseudouridine in Drosophila 28S rRNA. | https://en.wikipedia.org/wiki/Small_nucleolar_RNA_psi28S-2876 |
In molecular biology, Small nucleolar RNA psi28S-3316 is a member of the H/ACA class of snoRNA. This family is responsible for guiding the modification of uridine 3316 in Drosophila 28S rRNA to pseudouridine | https://en.wikipedia.org/wiki/Small_nucleolar_RNA_psi28S-3316 |
In molecular biology, Small nucleolar RNA psi28S-3327 (also known as snoRNA psi28S-3327) is a non-coding RNA (ncRNA) molecule which functions in the biogenesis (modification) of other small nuclear RNAs (snRNAs). This type of modifying RNA is located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a 'guide RNA'. This Drosophila specific snoRNA is a member of the H/ACA box class of snoRNA and is predicted to be responsible for guiding the modification of uridine 3327 in Drosophila 28S and U1920 in Drosophila 18S rRNA to pseudouridine. | https://en.wikipedia.org/wiki/Small_nucleolar_RNA_psi28S-3327 |
In molecular biology, Small nucleolar RNA psi28S-3327 (also known as snoRNA psi28S-3327) is a non-coding RNA (ncRNA) molecule which functions in the biogenesis (modification) of other small nuclear RNAs (snRNAs). This type of modifying RNA is located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a 'guide RNA'. This Drosophila-specific snoRNA is a member of the H/ACA box class of snoRNA and is predicted to be responsible for guiding the modification of uridines 1854 and 1937 to pseudouridine in Drosophila 18S rRNA. | https://en.wikipedia.org/wiki/Small_nucleolar_RNA_psi18S-1854 |
In molecular biology, Small nucleolar RNA snR52 (homologous to Z13) is a non-coding RNA (ncRNA) molecule which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA. | https://en.wikipedia.org/wiki/Small_nucleolar_RNA_Z13/snr52 |
snoRNA Z13 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs.snoRNA snR52 was initially discovered using a computational screen of the Saccharomyces cerevisiae genome; subsequent work identified Z13 in Schizosaccharomyces pombe. Further experiments have shown that snR52 is transcribed by RNA polymerase III. | https://en.wikipedia.org/wiki/Small_nucleolar_RNA_Z13/snr52 |
In molecular biology, Small nucleolar RNA snoM1 is a non-coding RNA (ncRNA) molecule which functions in the biogenesis (modification) of other small nuclear RNAs (snRNAs). This type of modifying RNA is located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a 'guide RNA'. M1 is a predicted to belong to the H/ACA box class of snoRNAs which are thought to guide the sites of modification of uridines to pseudouridines. snoM1 seems to be found exclusively in Drosophila species. | https://en.wikipedia.org/wiki/Small_nucleolar_RNA_snoM1 |
In molecular biology, Small nucleolar RNA snoR60 is a non-coding RNA (ncRNA) molecule which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA. | https://en.wikipedia.org/wiki/Small_nucleolar_RNA_snoR60 |
snoRNA snoR60 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs. Plant snoRNA snoR60 was identified in a screen of Arabidopsis thaliana. | https://en.wikipedia.org/wiki/Small_nucleolar_RNA_snoR60 |
In molecular biology, Small nucleolar RNA snoR86 (also known as snoR86) is a non-coding RNA (ncRNA) which modifies other small nuclear RNAs (snRNAs). It is a member of the H/ACA class of small nucleolar RNA that guide the sites of modification of uridines to pseudouridines. Plant snoR86 was identified in a screen of Arabidopsis thaliana. | https://en.wikipedia.org/wiki/Small_nucleolar_RNA_snoR86 |
In molecular biology, Small nucleolar RNA snoR98 (also known as snoR98) is a non-coding RNA (ncRNA) which modifies other small nuclear RNAs (snRNAs). It is a member of the H/ACA class of small nucleolar RNA that guide the sites of modification of uridines to pseudouridines. Plant snoR98 was identified in a screen of Arabidopsis thaliana. | https://en.wikipedia.org/wiki/Small_nucleolar_RNA_snoR98 |
In molecular biology, Smith-Magenis syndrome chromosome region, candidate 2 (non-protein coding), also known as SMCR2 is a long non-coding RNA. In humans, it is found in a region of chromosome 17 that is commonly deleted in Smith–Magenis syndrome. | https://en.wikipedia.org/wiki/SMCR2 |
In molecular biology, Snake H/ACA box small nucleolar RNA refers to a number of very closely related non-coding RNA (ncRNA) genes identified in snakes which have been predicted to be small nucleolar RNAs (snoRNAs). This type of ncRNA is involved in the biogenesis of other small nuclear RNAs and are often referred to as 'guide' RNAs. They are usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. These snoRNA genes were initially identified in the introns of the cardiotoxin 4 and cobrotoxin genes of the Taiwan cobra (Bungarus multicinctus) and the Taiwan banded krait (Bungarus multicinctus) during sequencing of these genes. These snoRNAs are predicted to act as H/ACA box type methylation guides as they have the predicted hairpin-hinge-hairpin-tail structure and extended regions of complementarity to 5S ribosomal RNA (rRNA). | https://en.wikipedia.org/wiki/Snake_H/ACA_box_small_nucleolar_RNA |
In molecular biology, Streptococcus sRNAs are small RNAs produced by species of Streptococcus bacteria. Several screens (both computational and experimental) have identified numerous sRNAs in different species and strains of Streptococcus including S. pneumoniae, S. pyogenes, S. agalactiae and S.mutans. The function of most of these is currently unknown, however a few have been characterised including FasX small RNA. Many sRNAs have roles in pathogenesis. | https://en.wikipedia.org/wiki/Streptococcus_sRNA |
In molecular biology, TACI-CRD2 represents the second cysteine-rich protein domain found in the TACI family of proteins. Members of this family are predominantly found in tumour necrosis factor receptor superfamily, member 13b (TACI), and are required for binding to the ligands APRIL and BAFF. TACI-CRD2 stands for Transmembrane Activator and CAML Interactor- Cysteine Rich Domain 2. | https://en.wikipedia.org/wiki/TACI-CRD2_protein_domain |
In molecular biology, TAZ zinc finger (Transcription Adaptor putative Zinc finger) domains are zinc-containing domains found in the homologous transcriptional co-activators CREB-binding protein (CBP) and the P300. CBP and P300 are histone acetyltransferases (EC) that catalyse the reversible acetylation of all four histones in nucleosomes, acting to regulate transcription via chromatin remodelling. These large nuclear proteins interact with numerous transcription factors and viral oncoproteins, including p53 tumour suppressor protein, E1A oncoprotein, MyoD, and GATA-1, and are involved in cell growth, differentiation and apoptosis. Both CBP and P300 have two copies of the TAZ domain, one in the N-terminal region, the other in the C-terminal region. | https://en.wikipedia.org/wiki/TAZ_zinc_finger |
The TAZ1 domain of CBP and P300 forms a complex with CITED2 (CBP/P300-interacting transactivator with ED-rich tail), inhibiting the activity of the hypoxia inducible factor (HIF-1alpha) and thereby attenuating the cellular response to low tissue oxygen concentration. Adaptation to hypoxia is mediated by transactivation of hypoxia-responsive genes by hypoxia-inducible factor-1 (HIF-1) in complex with the CBP and p300 transcriptional coactivators.The TAZ domain adopts an all-alpha fold with zinc-binding sites in the loops connecting the helices. The TAZ1 domain in P300 and the TAZ2 (CH3) domain in CBP have each been shown to have four amphipathic helices, organised by three zinc-binding clusters with HCCC-type coordination. == References == | https://en.wikipedia.org/wiki/TAZ_zinc_finger |
In molecular biology, TBR5 is a member of the C/D class of snoRNA which contain the C (UGAUGA) and D (CUGA) box motifs. Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs.Together with TBR7 and TBR17 it is a part of a tandemly repeated snoRNA gene cluster, located within the spliced leader RNA (SLA). The cluster genes are produced as polycistronic RNA. | https://en.wikipedia.org/wiki/Small_nucleolar_RNA_TBR5 |
In molecular biology, TBST (or TTBS) is a mixture of tris-buffered saline (TBS) (a buffer solution) and Polysorbate 20 (a polysorbate-type nonionic surfactant). Polysorbate 20 is also known as Tween 20, a commercial brand name. It is a common detergent used in many buffers for washing nitrocellulose membrane in western blotting and microtiter plate wells in ELISA assays. Tris is a buffer that maintains a pH of 7–9.2. | https://en.wikipedia.org/wiki/TBST |
In molecular biology, TCL-1/MTCP-1 is a protein domain found in proteins encoded for by two related protooncogenes, other words by genes that help promote cancer. They are, T-cell leukemia/lymphoma protein 1A TCL1A encoded by oncogene TCL-1 SWISSPROT and Protein p13 MTCP-1 encoded by MTCP-1 SWISSPROT. These are overexpressed in T cell prolymphocytic leukemias as a result of chromosomal rearrangements that involve the translocation of one T cell receptor gene to either chromosome 14q32 or Xq28. | https://en.wikipedia.org/wiki/TCL1_MTCP1_protein_domain |
In molecular biology, TUG-UBL1 refers to a protein that regulates a glucose transporter called GLUT4. TUG-UBL1 is an acronym for Tether containing UBX domain for GLUT4-Ubiquitin Like 1, this is encoded for by the gene, ASPSCR1. | https://en.wikipedia.org/wiki/TUG-UBL1_protein_domain |
In molecular biology, TauD refers to a protein domain that in many enteric bacteria is used to break down taurine (2-aminoethanesulfonic acid) as a source of sulfur under stress conditions. In essence, they are domains found in enzymes that provide bacteria with an important nutrient. | https://en.wikipedia.org/wiki/TauD_protein_domain |
In molecular biology, U105 belongs to the C/D family of snoRNAs. It is encoded in an intron of the Peter pan homolog gene and is predicted to guide 2'O-ribose methylation of residue U799 of the small 18S rRNA subunit. | https://en.wikipedia.org/wiki/Small_nucleolar_RNA_SNORD105 |
In molecular biology, U108 belongs to the H/ACA family of snoRNAs. The sequence is predicted to guide the pseudouridylation of the U372 residue in the 28S rRNA subunit. However it has not been reported as a pseudouridylation site. | https://en.wikipedia.org/wiki/Small_nucleolar_RNA_SNORA12 |
In molecular biology, U14 small nucleolar RNA (U14 snoRNA) is a non-coding RNA required for early cleavages of eukaryotic precursor rRNAs. In yeasts, this molecule possesses a stem-loop region (known as the Y-domain) which is essential for function. A similar structure, but with a different consensus sequence, is found in plants, but is absent in vertebrates. In human there are two closely related copies called SNORD14A and SNORD14B that are expressed from the intron of their host gene ribosomal protein Rps13. | https://en.wikipedia.org/wiki/Small_nucleolar_RNA_SNORD14 |
In molecular biology, U21 is a member of the C/D class of snoRNA which contain the C (UGAUGA) and D (CUGA) box motifs. U21 is encoded within an intron of the gene for ribosomal protein L5 in mammals, but within introns of the ADP ribosylation factor gene in Drosophila. U21 snoRNA has a 13 nucleotide region of complementarity with an invariant region of eukaryotic 28S ribosomal RNA. | https://en.wikipedia.org/wiki/Small_nucleolar_RNA_SNORD21 |
In molecular biology, U23 belongs to the H/ACA class of snoRNAs. snoRNAs bind a number of proteins (including dyskerin, Gar1p and Nop10p in the case of the H/ACA class) to form snoRNP complexes. This class are thought to guide the sites of modification of uridines to pseudouridines by forming direct base pairing interactions with substrate RNAs. | https://en.wikipedia.org/wiki/Small_nucleolar_RNA_SNORA75 |
Targets include ribosomal and spliceosomal RNAs as well as the Trypanosoma spliced leader RNA (SL RNA) as possibly other, still unknown cellular RNAs. U23 can direct the pseudouridylation of U97 in human 18S rRNA. U23 is encoded within intron 12 of the nucleolin gene in human, mouse, rat chicken, and Xenopus laevis. | https://en.wikipedia.org/wiki/Small_nucleolar_RNA_SNORA75 |
In molecular biology, U24 is a member of the C/D class of snoRNA which contain the C (UGAUGA) and D (CUGA) box motifs. C/D box snoRNAs have been shown to act as methylation guides for a number of RNA targets. U24 is encoded within an intron of the gene for ribosomal protein L7a in mammals, chicken and Fugu. | https://en.wikipedia.org/wiki/Small_nucleolar_RNA_SNORD24 |
The U76/SNORD76 snoRNA is found in an intron of the uRNA host gene (UHG) growth arrest specific 5 (GAS5) transcript gene. snoRNAs Z20 and U76 snoRNAs show clear similarity to U24. An experiment that looked at 22 different non-small-cell lung cancer tissues found that SNORD33, SNORD66 and SNORD76 were over-expressed relative to matched noncancerous lung tissues. | https://en.wikipedia.org/wiki/Small_nucleolar_RNA_SNORD24 |
In molecular biology, U3 snoRNA is a non-coding RNA found predominantly in the nucleolus. U3 has C/D box motifs that technically make it a member of the box C/D class of snoRNAs; however, unlike other C/D box snoRNAs, it has not been shown to direct 2'-O-methylation of other RNAs. Rather, U3 is thought to guide site-specific cleavage of ribosomal RNA (rRNA) during pre-rRNA processing.The box C/D element is a subset of the six short sequence elements found in all U3 snoRNAs, namely boxes A, A', B, C, C', and D. The U3 snoRNA secondary structure is characterized by a small 5' domain (with boxes A and A'), and a larger 3' domain (with boxes B, C, C', and D), the two domains being linked by a single-stranded hinge. Boxes B and C form the B/C motif, which appears to be exclusive to U3 snoRNAs, and boxes C' and D form the C'/D motif. | https://en.wikipedia.org/wiki/Small_nucleolar_RNA_U3 |
The latter is functionally similar to the C/D motifs found in other snoRNAs. The 5' domain and the hinge region act as a pre-rRNA-binding domain. The 3' domain has conserved protein-binding sites. | https://en.wikipedia.org/wiki/Small_nucleolar_RNA_U3 |
Both the box B/C and box C'/D motifs are sufficient for nuclear retention of U3 snoRNA. The box C'/D motif is also necessary for nucleolar localization, stability and hyper-methylation of U3 snoRNA. Both box B/C and C'/D motifs are involved in specific protein interactions and are necessary for the rRNA processing functions of U3 snoRNA. | https://en.wikipedia.org/wiki/Small_nucleolar_RNA_U3 |
In molecular biology, U71 belongs to the H/ACA class of Small nucleolar RNA (snoRNAs). snoRNAs bind a number of proteins (including dyskerin, Gar1p and Nop10p in the case of the H/ACA class) to form snoRNP complexes. This class are thought to guide the sites of modification of uridines to pseudouridines by forming direct base pairing interactions with substrate RNAs. Targets may include ribosomal and spliceosomal RNAs but the exact function of many snoRNAs, including U71, is unclear. | https://en.wikipedia.org/wiki/Small_nucleolar_RNA_SNORA71 |
In molecular biology, U8 small nucleolar RNA (also known as SNORD118) is the RNA component of a small RNA:protein complex (the U8 snoRNP) which is required for biogenesis of mature large subunit ribosomal RNAs, 5.8S and 28S rRNAs.More specifically, U8 is a non-coding RNA (ncRNA) molecule which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA. snoRNA U8 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs.U8 RNA genes have been identified in human, mouse, rat and the amphibian Xenopus laevis. | https://en.wikipedia.org/wiki/U8_small_nucleolar_RNA |
In molecular biology, U81 (also sometimes called Z23 snoRNA) is a member of the C/D class of snoRNA which contain the C (UGAUGA) and D (CUGA) box motifs. U81 acts as a guanine methylation guide and is found in intron 11 of the gas5 gene in mammals. | https://en.wikipedia.org/wiki/Small_nucleolar_RNA_SNORD81 |
In molecular biology, U83B belongs to the C/D family of snoRNAs. U83B like U83A has no documented RNA target and they share the same host gene with the C/D box snoRNA U43 (RPL3). N.B. U83A/B/C have no sequence similarity with the U83 snoRNA that was cloned by Jady and Kiss (2000). | https://en.wikipedia.org/wiki/Small_nucleolar_RNA_U83B |
In molecular biology, UDP-3-O-N-acetylglucosamine deacetylase (also known as UDP-3-O- N-acetylglucosamine deacetylase or UDP-3-O-acyl-GlcNAc deacetylase), EC 3.5.1.-, is a bacterial enzyme involved in lipid A biosynthesis. It is a zinc-dependent metalloamidase that catalyses the second and committed step in the biosynthesis of lipid A. Lipid A anchors lipopolysaccharide (the major constituent of the outer membrane) into the membrane in Gram negative bacteria. It shows no homology to mammalian metalloamidases and is essential for cell viability, making it an important target for the development of novel antibacterial compounds. The structure of UDP-3-O-N-acetylglucosamine deacetylase (LpxC) from Aquifex aeolicus has a two-layer alpha/beta structure similar to that of the second domain of ribosomal protein S5, only in LpxC there is a duplication giving two structural repeats of this fold, each repeat being elaborated with additional structures forming the active site. | https://en.wikipedia.org/wiki/UDP-3-O-N-acetylglucosamine_deacetylase |
LpxC contains a zinc-binding motif, which resides at the base of an active site cleft and adjacent to a hydrophobic tunnel occupied by a fatty acid. This tunnel accounts for the specificity of LpxC toward substrates and inhibitors bearing appropriately positioned 3-O-fatty acid substituents. == References == | https://en.wikipedia.org/wiki/UDP-3-O-N-acetylglucosamine_deacetylase |
In molecular biology, VAR1 protein domain, otherwise known as variant protein 1, is a ribosomal protein that forms part of the small ribosomal subunit in yeast mitochondria. Mitochondria possess their own ribosomes responsible for the synthesis of a small number of proteins encoded by the mitochondrial genome. VAR1 is the only protein in the yeast mitochondrial ribosome to be encoded in the mitochondria - the remaining approximately 80 ribosomal proteins are encoded in the nucleus. VAR1 along with 15S rRNA are necessary for the formation of mature 37S subunits. | https://en.wikipedia.org/wiki/Var1_protein_domain |
In molecular biology, VanY are protein domains found in enzymes named metallopeptidases. They are vital to bacterial cell wall synthesis and antibiotic resistance. | https://en.wikipedia.org/wiki/VanY_protein_domain |
In molecular biology, Vitamin D binding protein domain III protein domain is predominantly found in Vitamin D binding proteins (DBP). Vitamin D-binding protein (DBP)(also referred to as Gc-globulin) is synthesized primarily in the liver. This entry outlines the domain III of DBP. Domain III (amino acid 379–458) is G-actin binding region located in the C-terminal. | https://en.wikipedia.org/wiki/Vitamin_D_binding_protein_domain_III |
Domain (amino acids 373 to 403). This protein is found ubiquitously in vivo in significant quantities and can be detected in all fluid compartments. During acute phase inflammatory response, DBP levels tend to increase. | https://en.wikipedia.org/wiki/Vitamin_D_binding_protein_domain_III |
In molecular biology, XhoI is a type II restriction enzyme EC that recognise the double-stranded DNA sequence CTCGAG and cleaves after C-1. Type II restriction endonucleases (EC) are components of prokaryotic DNA restriction-modification mechanisms that protect the organism against invading foreign DNA. These site-specific deoxyribonucleases catalyse the endonucleolytic cleavage of DNA to give specific double-stranded fragments with terminal 5'-phosphates. == References == | https://en.wikipedia.org/wiki/XhoI |
In molecular biology, Xol-1 is a protein domain, also named the Switch protein, is essentially a sex-determining protein. This entry focuses on the N-terminal domain of Xol-1. Xol-1, the master switch gene controlling sex-determination system and dosage compensation. This protein is normally expressed in males, where it promotes male development and prevents dosage compensation. | https://en.wikipedia.org/wiki/XOL-1_Switch_protein_N-terminal_domain |
In molecular biology, YadA is a protein domain which is short for Yersinia adhesin A. These proteins have strong sequence and structural homology, particularly at their C-terminal end. The function is to promote their pathogenicity and virulence in host cells, though cell adhesion. YadA is found in three pathogenic species of Yersinia, Y. pestis, Y. pseudotuberculosis, and Y. enterocolitica. The YadA domain is encoded for by a virulence plasmid in Yersinia, which encodes a type-III secretion (T3S) system consisting of the Ysc injectisome and the Yop effectors. | https://en.wikipedia.org/wiki/YadA_bacterial_adhesin_protein_domain |
In molecular biology, YccV protein domain is also, alternatively named, Heat shock protein HspQ. This entry describes the small protein from Escherichia coli YccV and its homologs in other Pseudomonadota. YccV is now described as a hemimethylated DNA binding protein. The model entry describes a protein domain in longer eukaryotic proteins. | https://en.wikipedia.org/wiki/HspQ_protein_domain |
In molecular biology, Yce-I protein domain is a putative periplasmic protein. This entry represents the lipid-binding protein YceI from Escherichia coli and the polyisoprenoid-binding protein TTHA0802 from Thermus thermophilus. Its role is to help aid the biosynthesis of isoprenoid, an important molecule found in all living organisms. | https://en.wikipedia.org/wiki/YceI_protein_domain |
In molecular biology, YecM refers to a protein domain found in Escherichia coli. It is a conserved, hypothetical protein with sequence homologues found exclusively in bacteria. Several bacterial YecM proteins in this particular family are of unknown function. | https://en.wikipedia.org/wiki/YecM_bacterial_protein_domain |
In molecular biology, YgbB is a protein domain. This entry makes reference to a number of proteins from eukaryotes and prokaryotes which share this common N-terminal signature and appear to be involved in terpenoid biosynthesis. The YgbB protein is a putative enzyme thought to aid terpenoid and isoprenoid biosynthesis, a vital chemical in all living organisms. This protein domain is part of an enzyme which catalyses a reaction in a complex pathway. | https://en.wikipedia.org/wiki/YgbB_N_terminal_protein_domain |
In molecular biology, YopH, N-terminal refers to an evolutionary conserved protein domain. This entry represents the N-terminal domain of YopH protein tyrosine phosphatase (PTP). | https://en.wikipedia.org/wiki/YopH,_N-terminal |
In molecular biology, YopR is a protein domain commonly found in gram negative bacteria, in particular Yersinia and is a core domain. Proteins in this entry are type III secretion system effectors. They are named differently in different species and in Yersinia has been designated YopR (Yersinia outer protein R) which is encoded by the YscH (Yersinia secretion H) gene. | https://en.wikipedia.org/wiki/YopR_bacterial_protein_domain |
This Yop protein is unusual in that it is released to the extracellular environment rather than injected directly into the target cell as are most Yop proteins. A hallmark of Yersinia type III machines is the presence of needles extending from the bacterial surface. Needles perform two functions, firstly, as a channel to export effectors into the immune cells and secondly as a sensor. | https://en.wikipedia.org/wiki/YopR_bacterial_protein_domain |
In molecular biology, YqeY is a type of protein domain of unknown function. It is thought to have a role in protein synthesis, facilitating the production of charged transfer RNA used in the process of translating mRNA into protein. It is present as a domain of glutaminyl-tRNA synthetase (GlnRS) in almost all eukaryotes. | https://en.wikipedia.org/wiki/YqeY_protein_domain |
In molecular biology, Z12 small nucleolar RNA is a non-coding RNA (ncRNA) molecule which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA. Z12 snoRNA belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs. | https://en.wikipedia.org/wiki/Z12_small_nucleolar_RNA |
In molecular biology, Z248 is a member of the C/D class of snoRNA which contain the C (UGAUGA) and D (CUGA) box motifs. Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs. | https://en.wikipedia.org/wiki/Small_nucleolar_RNA_Z248 |
In molecular biology, Z30 small nucleolar RNA, also known as SNORD7, is a non-coding RNA (ncRNA) molecule which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA. Z30 snoRNA belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs. | https://en.wikipedia.org/wiki/Z30_small_nucleolar_RNA |
In molecular biology, Z6 small nucleolar RNA is a non-coding RNA (ncRNA) molecule which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA. Z6 snoRNA belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs. | https://en.wikipedia.org/wiki/Z6_small_nucleolar_RNA |
In molecular biology, ZinT (formerly known as YodA) is a family of protein domains found in prokaryotes. The domain contains a single binding site that can accommodate a divalent cation, with a geometry suggestive of zinc binding. This family was first thought to be part of the bacterial response to a toxic heavy metal cadmium by binding to the metal to ensure its elimination; however, more recent work has suggested a role in zinc homeostasis. | https://en.wikipedia.org/wiki/ZinT_protein_domain |
In molecular biology, a CCAAT box (also sometimes abbreviated a CAAT box or CAT box) is a distinct pattern of nucleotides with GGCCAATCT consensus sequence that occur upstream by 60–100 bases to the initial transcription site. The CAAT box signals the binding site for the RNA transcription factor, and is typically accompanied by a conserved consensus sequence. It is an invariant DNA sequence at about minus 70 base pairs from the origin of transcription in many eukaryotic promoters. Genes that have this element seem to require it for the gene to be transcribed in sufficient quantities. | https://en.wikipedia.org/wiki/CAAT_box |
It is frequently absent from genes that encode proteins used in virtually all cells. This box along with the GC box is known for binding general transcription factors. | https://en.wikipedia.org/wiki/CAAT_box |
Both of these consensus sequences belong to the regulatory promoter. Full gene expression occurs when transcription activator proteins bind to each module within the regulatory promoter. Protein specific binding is required for the CCAAT box activation. These proteins are known as CCAAT box binding proteins/CCAAT box binding factors. A CCAAT box is a feature frequently found before eukaryote coding regions, but is not found in prokaryotes. | https://en.wikipedia.org/wiki/CAAT_box |
In molecular biology, a GC box, also known as a GSG box, is a distinct pattern of nucleotides found in the promoter region of some eukaryotic genes. The GC box is upstream of the TATA box, and approximately 110 bases upstream from the transcription initiation site. It has a consensus sequence GGGCGG which is position-dependent and orientation-independent. The GC elements are bound by transcription factors and have similar functions to enhancers. | https://en.wikipedia.org/wiki/GC_box |
Some known GC box-binding proteins include Sp1, Krox/Egr, Wilms' tumor, MIGI, and CREA.The GC box is commonly the binding site for zinc finger proteins. An alpha helix section of the protein corresponds with a major groove in the DNA. Zinc-fingers bind to triplet base pair sequences, with residue 21 binding to the first base pair, residue 18 binding to the second base pair, and residue 15 binding to the third base pair. | https://en.wikipedia.org/wiki/GC_box |
The triplet base pairs can either be a GGG or a GCG. If residue 18 is a histidine, it will bind to a G, and if residue 18 is a glutamate, it will bind to a C. GC box-binding zinc fingers have between 2 and 4 fingers, making them interact with base pair sequences that are 6 to 8 base pairs in length. == References == | https://en.wikipedia.org/wiki/GC_box |
In molecular biology, a RING (short for Really Interesting New Gene) finger domain is a protein structural domain of zinc finger type which contains a C3HC4 amino acid motif which binds two zinc cations (seven cysteines and one histidine arranged non-consecutively). This protein domain contains 40 to 60 amino acids. Many proteins containing a RING finger play a key role in the ubiquitination pathway. | https://en.wikipedia.org/wiki/RING_finger_domain |
In molecular biology, a SANT domain is a protein domain that allows many chromatin remodeling proteins to interact with histones. The name SANT is an acronym standing for "Swi3, Ada2, N-Cor, and TFIIIB". It is part of the extended SANT/Myb family. == References == | https://en.wikipedia.org/wiki/SANT_domain |
In molecular biology, a Tudor domain is a conserved protein structural domain originally identified in the Tudor protein encoded in Drosophila. The Tudor gene was found in a Drosophila screen for maternal factors that regulate embryonic development or fertility. Mutations here are lethal for offspring, inspiring the name Tudor, as a reference to the Tudor King Henry VIII and the several miscarriages experienced by his wives. | https://en.wikipedia.org/wiki/Tudor_domain |
In molecular biology, a batch effect occurs when non-biological factors in an experiment cause changes in the data produced by the experiment. Such effects can lead to inaccurate conclusions when their causes are correlated with one or more outcomes of interest in an experiment. They are common in many types of high-throughput sequencing experiments, including those using microarrays, mass spectrometers, and single-cell RNA-sequencing data. They are most commonly discussed in the context of genomics and high-throughput sequencing research, but they exist in other fields of science as well. | https://en.wikipedia.org/wiki/Batch_effects |
In molecular biology, a cap-independent translation element (CITE or 3'CITE) is an RNA sequence found in the 3'UTR of many RNA plant viruses. Eukaryotic mRNAs contain a 5' cap structure which is required for efficient binding of translation initiation factors. Many viral mRNAs lack the 5' cap, animal virus mRNAs often contain an internal ribosome entry site which functions in translation initiation. | https://en.wikipedia.org/wiki/Cap-independent_translation_element |
Many plant viral mRNAs contain a cap-independent translation element. These elements mediate initiation of translation of the proteins encoded in the mRNA by either recruiting translation initiation factors or the 60S ribosomal subunit to the viral RNA. In RNA2 of Red clover necrotic mosaic virus (RCNMV) the cap-independent translation element is required for negative strand RNA synthesis.There are many different structural classes of cap-independent translation element, with no apparent structural or sequence similarity: | https://en.wikipedia.org/wiki/Cap-independent_translation_element |
In molecular biology, a carbohydrate-binding module (CBM) is a protein domain found in carbohydrate-active enzymes (for example glycoside hydrolases). The majority of these domains have carbohydrate-binding activity. Some of these domains are found on cellulosomal scaffoldin proteins. CBMs were previously known as cellulose-binding domains. | https://en.wikipedia.org/wiki/Carbohydrate-binding_module |
CBMs are classified into numerous families, based on amino acid sequence similarity. There are currently (June 2011) 64 families of CBM in the CAZy database.CBMs of microbial glycoside hydrolases play a central role in the recycling of photosynthetically fixed carbon through their binding to specific plant structural polysaccharides. | https://en.wikipedia.org/wiki/Carbohydrate-binding_module |
CBMs can recognise both crystalline and amorphous cellulose forms. CBMs are the most common non-catalytic modules associated with enzymes active in plant cell-wall hydrolysis. Many putative CBMs have been identified by amino acid sequence alignments but only a few representatives have been shown experimentally to have a carbohydrate-binding function. | https://en.wikipedia.org/wiki/Carbohydrate-binding_module |
In molecular biology, a chromatosome is a result of histone H1 binding to a nucleosome, which contains a histone octamer and DNA. The chromatosome contains 166 base pairs of DNA. 146 base pairs are from the DNA wrapped around the histone core of the nucleosome. The remaining 20 base pairs are from the DNA of histone H1 binding to the nucleosome. | https://en.wikipedia.org/wiki/Chromatosome |
Histone H1, and its other variants, are referred to as linker histones. Protruding from the linker histone are linker DNA. Chromatosomes are connected to each other when the linker DNA of one chromatosome binds to the linker histone of another chromatosome. | https://en.wikipedia.org/wiki/Chromatosome |
In molecular biology, a displacement loop or D-loop is a DNA structure where the two strands of a double-stranded DNA molecule are separated for a stretch and held apart by a third strand of DNA. An R-loop is similar to a D-loop, but in this case the third strand is RNA rather than DNA. The third strand has a base sequence which is complementary to one of the main strands and pairs with it, thus displacing the other complementary main strand in the region. Within that region the structure is thus a form of triple-stranded DNA. A diagram in the paper introducing the term illustrated the D-loop with a shape resembling a capital "D", where the displaced strand formed the loop of the "D".D-loops occur in a number of particular situations, including in DNA repair, in telomeres, and as a semi-stable structure in mitochondrial circular DNA molecules. | https://en.wikipedia.org/wiki/D-loop |
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