| { |
| "patient_demographics": { |
| "patient_id": "ANODE-ONC-75270", |
| "age": 80, |
| "gender": "Female", |
| "ethnicity": "Hispanic" |
| }, |
| "clinical_oncology_profile": { |
| "primary_diagnosis": "Infiltrating Ductal Carcinoma (Breast Cancer)", |
| "stage_at_presentation": "T2N0M0 (Stage IIA)", |
| "histological_grade": "Grade 1 (Well Differentiated)", |
| "biomarker_status": { |
| "ER": "Positive (60%)", |
| "PR": "Positive (75%)", |
| "HER2": "Negative (1+ by IHC)" |
| } |
| }, |
| "genomic_sequencing_data": { |
| "sequencing_type": "Targeted Next-Generation Sequencing (NGS)", |
| "somatic_variants_detected": [ |
| { |
| "gene": "PIK3CA", |
| "alteration": "p.E545K", |
| "variant_allele_frequency_vaf": 0.46 |
| }, |
| { |
| "gene": "ESR1", |
| "alteration": "p.D538G", |
| "variant_allele_frequency_vaf": 0.23 |
| }, |
| { |
| "gene": "TP53", |
| "alteration": "p.R273H", |
| "variant_allele_frequency_vaf": 0.42 |
| } |
| ] |
| }, |
| "longitudinal_treatment_ehr": { |
| "line_of_therapy": 1, |
| "regimen_administered": "Palbociclib + Letrozole", |
| "cycles_completed": 7, |
| "adverse_events_ctcae_v5": [ |
| { |
| "toxicity": "Fatigue", |
| "grade": 3, |
| "action_taken": "Supportive care" |
| } |
| ], |
| "treatment_response_recist_1_1": "Complete Response (CR)", |
| "progression_free_survival_months": 50.0 |
| } |
| } |
