PMID int64 2.09k 36.2M | Title stringlengths 21 414 | Abstract stringlengths 175 8.83k | Split stringclasses 1
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7,746,058 | Baseline serum cholesterol and treatment effect in the Scandinavian Simvastatin Survival Study (4S) | We examined the relation between the risk of major coronary events (coronary death and non-fatal myocardial infarction) and baseline cholesterol levels in patients with coronary heart disease, randomised to placebo or simvastatin therapy in the Scandinavian Simvastatin Survival Study (4S). The relative risk reduction i... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | [
1,
1,
1,
1,
1,
1,
0,
1
] | 126 |
19,102,862 | [Impact of statins on clopidogrel platelet inhibition in patients with acute coronary syndrome or stable angina]. | This prospective registered study was conducted to investigate the impact of statins (pravastatin, fluvastatin, atorvastatin) on clopidogrel platelet inhibition in patients with acute coronary syndrome (ACS) or stable angina. A total of 1015 consecutive patients with ACS or stable angina underwent coronary angiography/... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | [
1,
1,
1,
1,
1,
1,
1,
1
] | 127 |
19,222,406 | Decrease in suicide among the individuals treated with antidepressants: a controlled study of antidepressants in suicide, Sweden 1995-2005. | Ecological studies have demonstrated a substantial decrease in suicide in parallel with an increase in the use of antidepressants. Causality cannot, however, be inferred from such studies. The aim of this study was to test on the individual level the hypothesis that treatment with antidepressant medication has been a s... | Train | 3 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | [
1,
1,
1,
1,
0,
1,
1,
1
] | 128 |
14,699,540 | Postoperative prophylactic antibiotic treatment in third molar surgery--a necessity? | We evaluated the need for prophylactic postoperative oral antibiotic treatment in the removal of asymptomatic third molars. In a prospective study of more than 30 months, a total of 528 impacted lower third molars were surgically removed in 288 patients. All patients were referred to our department by a dentist or a ge... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | [
1,
1,
1,
1,
1,
1,
1,
1
] | 129 |
19,452,483 | Impact of high-dose atorvastatin in coronary heart disease patients age 65 to 78 years. | High-dose statin therapy may be underutilized in aged patients due to doubts about efficacy and safety. To investigate outcomes and safety in patients aged 65-78 years compared with patients aged < 65 years in the ALLIANCE study. A total of 2,442 stable coronary heart disease (CHD) patients with dyslipidemia were rando... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | [
1,
1,
1,
1,
1,
1,
1,
0
] | 130 |
66,119 | The treatment of Hodgkin's disease: emphasizing programs at the Clinic Center, National Institutes of Health. | During the past 10--15 years there has been a dramatic improvement in the prognosis of patients with Hodgkin's diases. More than 80% of all patients now will live 5+ years, many of them free from disease. The well-recognized immediate complications of therapy discussed above, are insignificant compared to the tremendou... | Train | 3 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | [
1,
1,
1,
0,
0,
0,
0,
0
] | 131 |
8,792,694 | Lansoprazole prevents recurrence of erosive reflux esophagitis previously resistant to H2-RA therapy. The Lansoprazole Maintenance Study Group. | This randomized, double-blind study was designed to determine whether the proton pump inhibitor lansoprazole could prevent relapse among patients with healed erosive reflux esophagitis that had been resistant to healing with at least 3 months of H2-receptor antagonist therapy. By the end of the year, 13% of placebo pat... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | [
1,
1,
1,
1,
1,
1,
0,
1
] | 133 |
1,863,141 | Cardiac transplantation with corticosteroid-free immunosuppression: long-term results. | To assess the long-term safety of an immunosuppressive regimen without corticosteroids, we retrospectively evaluated 42 long-term (greater than 1 year) survivors of orthotopic cardiac transplantation. We determined the incidence of (1) conversion of the immunosuppressive regimen from cyclosporine and azathioprine alone... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | [
1,
1,
1,
1,
1,
1,
1,
0
] | 134 |
1,362,537 | The debrisoquine metabolic phenotype and DNA-based assays: implications of misclassification for the association of lung cancer and the debrisoquine metabolic phenotype. | Debrisoquine is an antihypertensive drug that is metabolized by cytochrome P4502D6. Deficient metabolism is inherited as an autosomal recessive condition. We previously reported in a case-control study that extensive metabolizers of debrisoquine were at greater risk of lung cancer compared to poor and intermediate meta... | Train | 3 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | [
1,
0,
1,
0,
0,
1,
0,
0
] | 135 |
9,217,194 | Treatment of adults with acute lymphoblastic leukaemia in first bone marrow relapse: results of the ALL R-87 protocol. | Sixty-one adults aged <55 years with acute lymphoblastic leukaemia (ALL) in first bone marrow relapse were enrolled in an Italian cooperative study (ALL R-87 protocol) from 12 GIMEMA Institutions. The treatment programme consisted of: (1) an induction phase with intermediate-dose cytarabine (IDARA-C 1 g/m2, 6 h daily i... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | [
1,
1,
1,
1,
1,
1,
1,
0
] | 138 |
26,626,451 | A retrospective pilot study examining the use of Acthar gel in sarcoidosis patients. | Acthar was reported as effective for the treatment of pulmonary sarcoidosis in the 1950s. Use of drug waned due to cost and toxicity compared to prednisone. Recent interest has reemerged as an alternative to high dose oral glucocorticoids. Chart review was performed on all advanced sarcoidosis patients seen at two cent... | Train | 3 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | [
1,
1,
1,
1,
0,
1,
1,
0
] | 139 |
7,515,648 | Analysis of long-term results and prognostic factors among 138 patients with advanced Hodgkin's disease treated with the alternating MOPP/ABVD chemotherapy. | A prospective study was conducted to assess (a) the long-term results and toxicity of the alternating MOPP/ABVD regimen in advanced Hodgkin's disease; (b) the prognostic value of pretreatment variables and of drug dose intensity. A total 138 consecutive patients with advanced Hodgkin's disease entered this study; patie... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | [
1,
1,
1,
1,
1,
1,
1,
1
] | 140 |
29,477,817 | Prognostic impact of elevated serum uric acid levels on long-term outcomes in patients with chronic heart failure: A post-hoc analysis of the GISSI-HF (Gruppo Italiano per lo Studio della Sopravvivenza nella Insufficienza Cardiaca-Heart Failure) trial. | The prognostic impact of hyperuricemia on long-term clinical outcomes in patients with chronic heart failure (HF) has been investigated in observational registries and clinical trials, but the results have been often inconclusive. We examined the prognostic impact of elevated serum uric acid levels on long-term clinica... | Train | 3 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | [
1,
0,
1,
0,
1,
1,
0,
0
] | 141 |
14,581,985 | Differential prescribing of inhaled corticosteroids in New Zealand general practice. | To determine how inhaled budesonide, beclomethasone and fluticasone are prescribed by general practitioners in New Zealand. Retrospective study of computerised clinical records from 42 general practices in New Zealand for the period 1 July 1997 to 30 June 1998. The study population comprised 174 929 consulting patients... | Train | 3 | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | [
1,
1,
0,
0,
1,
1,
1,
0
] | 142 |
9,515,971 | A double-blind trial of fluoxetine in pathologic skin picking. | Our objective was to determine the efficacy of fluoxetine in the treatment of pathologic skin picking in a double-blind, placebo-controlled, parallel trial. Twenty-one adults with chronic pathologic skin picking agreed to participate and received 10 weeks of placebo or fluoxetine with a flexible dosing schedule up to 8... | Train | 3 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | [
1,
1,
1,
1,
0,
1,
1,
1
] | 143 |
12,911,659 | Comparison of the effect on intragastric pH of a single dose of omeprazole or rabeprazole: which is suitable for on-demand therapy? | An ideal medication for heartburn should have the rapid onset of action needed for on-demand treatment. However, assessment of the onset of action of proton pump inhibitors has been largely subjective. We compared the inhibitory effect on gastric acid secretion of a single oral dose of omeprazole with that of rabeprazo... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | [
1,
1,
1,
1,
1,
1,
1,
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] | 146 |
14,674,932 | No effect of montelukast on asthma-like symptoms in elite ice hockey players. | Controlled clinical trials on the effects of leukotriene antagonists on asthma-like symptoms, bronchial hyperresponsiveness and airway inflammation have not been performed in elite athletes. In 2001, we examined 88 of 102 (86%) players from three junior, national league ice hockey teams in Helsinki. Athletes were inclu... | Train | 3 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | [
1,
1,
1,
1,
0,
1,
1,
1
] | 147 |
8,732,173 | Analysis of hepatitis B virus precore variants in hepatitis B e antibody-positive patients treated with prednisone plus interferon. | To assess the effects of prednisone and interferon on the distribution of hepatitis B virus (HBV) precore mutants, nine hepatitis B e antibody (HBeAb)-positive patients with HBV chronic infection were studied. Patients were treated with prednisone (30 mg day-1 for 4 weeks, followed by 20 mg day-1 for 2 weeks and by 10 ... | Train | 3 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | [
1,
1,
1,
1,
0,
1,
1,
0
] | 148 |
21,897,213 | Simvastatin displays an antioxidative effect by inhibiting an increase in the serum 8-isoprostane level in patients with acute ischemic stroke: brief report. | Oxidative stress plays an important role in ischemic stroke pathophysiology. Some drugs are known to have a substantial influence on oxidative stress. In this study, we examined the antioxidant effect of simvastatin through its influence on patients' serum 8-isoprostane levels. We measured serum 8-isoprostane levels in... | Train | 3 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | [
1,
1,
1,
1,
0,
1,
1,
1
] | 149 |
26,768,436 | Chemotherapy-induced nausea and vomiting: incidence and characteristics of persistent symptoms and future directions NCCTG N08C3 (Alliance). | Despite newer agents, chemotherapy-induced nausea and vomiting (CINV) continues to remain a distressing side effect to a proportion of patients undergoing systemic anti-cancer therapy. We recently performed an unplanned secondary analysis on a previously reported negative phase III trial (N08C3) looking at the efficacy... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | [
1,
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1,
1,
1,
1,
1,
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] | 150 |
29,945,806 | Prevalence, long-term prognosis and medical alternatives for patients admitted for acute coronary syndromes and prasugrel contraindication. | Prasugrel is a potent antiplatelet therapy that has demonstrated to be superior to clopidogrel for patients with acute coronary syndromes (ACS) but has three main contraindications. Prospective study of all patients admitted for ACS in two hospitals. Prasugrel contraindication group was defined by the presence of age >... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | [
1,
1,
1,
1,
1,
1,
1,
1
] | 151 |
1,350,491 | Acute hemodynamic effects of carvedilol in comparison with propranolol in patients with coronary heart disease. | In a randomized, double-blind study oral doses of 50 mg carvedilol (Dilatrend) were compared with 40 mg propranolol in 16 male patients with coronary heart disease, CHD [12 without significant stenoses following percutaneous transluminal coronary angioplasty (PTCA), 4 with multivessel disease]. Bicycle ergometry in the... | Train | 3 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | [
1,
1,
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1,
0,
1,
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] | 152 |
9,571,652 | The serotonin reuptake inhibitor sertraline reduces excessive alcohol consumption in nonhuman primates: effect of stress. | Many monkeys that are reared without adult influence, with only peers, voluntarily consume alcohol in amounts producing intoxication on a relatively regular basis. Using a cross-over design, eight adolescent, peer-reared rhesus monkeys were allowed unfettered access to an 8.4% ethanol solution and treated with 20 mg/kg... | Train | 3 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | [
1,
0,
1,
1,
0,
1,
1,
0
] | 153 |
16,866,863 | Evaluation of health-related quality of life in gastroesophageal reflux disease patients before and after treatment with pantoprazole. | Gastrooesophageal reflux disease (GERD) is highly prevalent in the Western world but its true population prevalence is difficult to estimate without a validated instrument to detect it. The evaluation of health-related quality of life (HRQoL) is an useful tool in this assessment. The aims of this study are to translate... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | [
1,
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1,
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1,
1,
0
] | 155 |
31,929,534 | Radioiodine therapy and Graves' disease - Myths and reality. | Autoimmune reactions in Graves' disease (GD) occur not only in the thyroid gland, but also in the orbital connective tissue, eyelids, extraocular muscles. The occurrence of orbitopathy in the course of GD is influenced by environmental factors, e.g. cigarette smoking. The aim of the study was to analyze the effect of c... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | [
1,
1,
1,
1,
1,
1,
1,
0
] | 158 |
9,571,327 | Treatment of hypercholesterolemia and combined hyperlipidemia with simvastatin and gemfibrozil in patients with NIDDM. A multicenter comparison study. | To compare the lipid-lowering efficacies of simvastatin and gemfibrozil in NIDDM patients with combined (mixed) hyperlipidemia (CHL) or isolated hypercholesterolemia (IHC). Patients with primary dyslipidemia and NIDDM were recruited for this double-blind, double-dummy comparison study from 10 Finnish centers. After a 4... | Train | 3 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | [
1,
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0,
1,
1,
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] | 159 |
30,790,132 | Effectiveness and Adherence to Treatment with Perindopril/Indapamide/Amlodipine Single-Pill Combination in a Greek Population with Hypertension. | Despite the overwhelming evidence and the established benefits of antihypertensive treatment, adherence to treatment remains low. To assess the adherence to treatment with a perindopril/indapamide/amlodipine single-pill combination (SPC), its effectiveness on blood pressure (BP) reduction, as well as the safety and tol... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | [
1,
1,
1,
1,
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1,
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] | 160 |
28,643,317 | [Effect of metformin on colorectal carcinoma in type 2 diabetes mellitus patients: a Markov model analysis]. | To evaluate the colorectal cancer (CRC) prevention effect of metformin in comparison with that of other T2DM medications from a Markov model perspective. Literature concerning CRC morbidity of T2DM patients with metformin or other diabetes medications treatment was reviewed in PubMed and Cochrane Library database from ... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | [
1,
1,
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1,
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1,
1,
0
] | 162 |
3,987,782 | Prazosin once or twice daily? | In 20 patients with long-standing essential hypertension, a comparison was made in a randomized cross-over study of the effect of once and twice daily prazosin administration on blood pressure levels. Concurrent medication (beta-blocker and/or saluretic once daily) remained constant throughout the study. Blood pressure... | Train | 3 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | [
1,
1,
1,
1,
0,
1,
1,
0
] | 163 |
14,721,795 | A feasibility study of the safety and efficacy of a combined clopidogrel and aspirin regimen following off-pump coronary artery bypass grafting. | Effective antiplatelet therapy may decrease the risk of complications following off-pump coronary artery bypass surgery (CABG). We prospectively evaluated the safety and early efficacy of a combined regimen of clopidogrel and aspirin starting immediately after off-pump CABG. One hundred thirty-five consecutive off-pump... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | [
1,
1,
1,
1,
1,
1,
1,
0
] | 164 |
22,575,771 | [Children orbital floor fracture: retrospective study, about 34 cases]. | Orbital fractures represent 30 % of children facial fractures. Nausea and vomiting are more predictive of entrapment than local trauma stigmatisms. Entrapment and diplopia are more frequent in adults. Delay for surgery is unclear in literature varying from 6 hours to days. The aim of this study is to summarise the aspe... | Train | 3 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | [
1,
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1,
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1,
1,
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] | 165 |
24,451,078 | In vitro dissolution and in vivo gamma scintigraphic evaluation of press-coated salbutamol sulfate tablets. | The aim of this study was to investigate the in vitro and in vivo performance of salbutamol sulfate press-coated tablets for delayed release. The in vitro release behavior of press-coated tablets with the outer layer of PEG 6000/ Eudragit S100 blends (2:1) in pH 1.2 (0.1 mol L-1 HCl) and then pH 6.8 buffer solution was... | Train | 3 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | [
1,
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1,
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1,
0,
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] | 167 |
26,160,213 | Liver injury correlates with biomarkers of autoimmunity and disease activity and represents an organ system involvement in patients with systemic lupus erythematosus. | Liver disease (LD), defined as ≥ 2-fold elevation of aspartate aminotransferase (AST) or alanine aminotransferase (ALT), was examined in a longitudinal study of systemic lupus erythematosus (SLE) patients. Among 435 patients, 90 (20.7%) had LD with a greater prevalence in males (15/39; 38.5%) than females (75/396; 18.9... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | [
1,
1,
1,
1,
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0,
1,
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] | 168 |
7,506,335 | Torasemide in the treatment of arterial hypertension. | An important role for diuretics in the treatment of hypertension is assured on the basis of the latest randomized, prospective trials. Although thiazide diuretics have been the mainstay of treatment thus far, they continue to engender debate because of putative, undesirable side effects. Older loop diuretics, such as f... | Train | 3 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | [
1,
0,
1,
0,
0,
1,
0,
0
] | 169 |
9,750,975 | Fluoxetine treatment of acral lick dermatitis in dogs: a placebo-controlled randomized double blind trial. | The aim of the study was to assess the efficacy and tolerability of fluoxetine treatment of acral lick dermatitis (ALD) in dogs and to investigate ALD as an animal model of obsessive-compulsive disorder (OCD). Sixty-three dogs with ALD were treated with fluoxetine 20 mg daily, or placebo, for 6 weeks. In the fluoxetine... | Train | 3 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | [
1,
0,
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1,
1,
1,
1,
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] | 170 |
30,097,339 | Comparative effectiveness of add-on therapy with newer-generation antiepileptic drugs in Bulgarian patients with refractory epilepsy. | The objective of this study is to perform an open, prospective study on various aspects of comparative effectiveness of newer-generation antiepileptic drugs as add-on therapy in Bulgarian patients with drug-resistant epilepsy. The study was performed with the participation of 1259 patients with epilepsy who attended th... | Train | 3 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | [
1,
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1,
0,
1,
1,
1
] | 171 |
2,368,891 | Oral premedication in children: a comparison of chloral hydrate, diazepam, alprazolam, midazolam and placebo for day surgery. | A double-blind study consisting of 339 randomly selected children investigated the effects of several premedicants on the preoperative and postoperative behaviour of children who underwent day-stay surgery. Patients were allocated into two groups. Group 1 consisted of 165 children aged between 6 and 47 months. Group 2 ... | Train | 3 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | [
1,
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1,
0,
1,
1,
1
] | 172 |
18,520,609 | Clinical toxicology of citalopram after acute intoxication with the sole drug or in combination with other drugs: overview of 26 cases. | There is discussion concerning the cardiac safety of citalopram in an overdose. The aim of this study was to investigate the toxic effects and toxicokinetic parameters of citalopram in an overdose as a single drug and in combination with other drugs. Cases observed between 1997 and 2006 were evaluated. Patient demograp... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | [
1,
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1,
1,
1,
1,
0
] | 173 |
16,044,100 | Determinants of mycophenolic acid levels after renal transplantation. | There are data suggesting an association between mycophenolic acid (MPA) levels and acute rejection and toxicity in renal transplant recipients treated with mycophenolate mofetil (MMF), and therefore, knowledge of factors determining MPA levels may aid in accurate adjustment of MMF dosage. A total of 4970 samples taken... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | [
1,
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1,
1,
1,
1,
0
] | 175 |
17,845,759 | [Primary diffuse large B-cell lymphoma of testis: a clinicopathologic study of 14 cases]. | To study the clinicopathologic features, immunohistochemical findings and prognosis of primary diffuse large B-cell lymphoma (DLBCL) of testis. Fourteen cases of primary DLBCL of testis, diagnosed according to the 2001 World Health Organization staging standards for hematopoietic and lymphoid tumors, were retrospective... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | [
1,
1,
1,
1,
1,
1,
1,
0
] | 176 |
1,290,314 | Time course of serum Lp(a) in men after coronary artery bypass grafting. | The serum Lp(a) time course was studied in 100 male patients who underwent coronary artery bypass grafting (CABG). The patients were randomized in a placebo (N = 50) and pravastatin treated (N = 50) group. The pravastatin regimen was 10 mg daily from the third postoperative day on and 20 mg daily after 1 week during 11... | Train | 3 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | [
1,
1,
1,
1,
0,
1,
1,
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] | 177 |
2,093,020 | Prevention of relapse of reflux oesophagitis after endoscopic healing: the efficacy and safety of omeprazole compared with ranitidine. | The prognosis for the acute healing of patients with persistent, erosive or ulcerative reflux oesophagitis depends upon the choice of drug treatment as well as the severity of the initial oesophagitis. The results of this study show that omeprazole, 40 mg once daily (n = 51), is more effective than ranitidine, 300 mg b... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | [
1,
1,
1,
1,
1,
1,
1,
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] | 179 |
8,361,220 | Treatment results of three consecutive Brazilian cooperative childhood ALL protocols: GBTLI-80, GBTLI-82 and -85. ALL Brazilian Group. | The Brazilian Cooperative Group for Treatment of Childhood Acute Lymphocytic Leukemia (GBTLI) has started clinical activities trials in 1980. Three consecutive multicenter studies in children with unprevious treated ALL have been completed including 994 patients. The first GBTLI-80 accrued 203 children from 1980 to 198... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | [
1,
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1,
1,
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1,
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] | 180 |
12,425,803 | [Comparison of pantoprazole and omeprazole-based triple therapy regimens in the treatment of Helicobacter pylori infection]. | To compare the efficacies of pantoprazole and omeprazole-based triple regimens in the treatment of H. pylori infection for 1-week or 2-week. 147 patients with H. pylori associated gastritis were randomly divided into pantoprazole triple regimen group (pantoprazole 40 mg, amoxicillin 1 g, and metronidazole 400 mg, bid,f... | Train | 3 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | [
1,
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0,
1,
1,
1,
0
] | 181 |
29,445,271 | Immune cell response to strenuous resistive breathing: comparison with whole body exercise and the effects of antioxidants. | Whole body exercise (WBE) changes lymphocyte subset percentages in peripheral blood. Resistive breathing, a hallmark of diseases of airway obstruction, is a form of exercise for the inspiratory muscles. Strenuous muscle contractions induce oxidative stress that may mediate immune alterations following exercise. We hypo... | Train | 3 | 1 | 1 | 1 | 0 | 0 | 1 | 1 | 0 | [
1,
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0,
0,
1,
1,
0
] | 183 |
7,661,838 | The use of amphetamines in U.S. Air Force tactical operations during Desert Shield and Storm. | Today's battleground requires round-the-clock air support. Modern aircraft systems enable tactical aircraft to be flown in all weather conditions, day or night, and for prolonged periods. U.S. Air Force Tactical Air Command (TAC) aircrew who deployed to the Southwest Asia Area of Responsibility (SWA AOR) for Operation ... | Train | 3 | 1 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | [
1,
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0,
1,
1,
0,
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] | 184 |
32,248,578 | Thioredoxin-1 as a biological predictive marker for selecting diffuse large B-cell lymphoma patients for etoposide-containing treatment. | In diffuse large B-cell lymphoma (DLBCL), there is an unmet medical need to select patients who would benefit from intensified frontline treatments such as adding etoposide to an R-CHOP regimen. The present work included a retrospective clinical analysis of two patient cohorts and an in vitro study. Primary biopsy samp... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | [
1,
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1,
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1,
1,
0
] | 185 |
24,062,147 | Dose-finding study of landiolol hydrochloride: a short-acting β1-blocker for controlling heart rate during coronary computed-tomography angiography in Japan. | Coronary computed-tomography angiography (CCTA) has high diagnostic performance, but it sometimes does not allow evaluation because of artifacts. Currently, the use of a β-blocker is recommended to prevent motion artifacts, but the β-blocker (metoprolol, propranolol, etc.) commonly used has a slow onset and long durati... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | [
1,
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] | 186 |
12,271,449 | Liquid chromatography/tandem mass spectrometry for the determination of fluoxetine and its main active metabolite norfluoxetine in human plasma with deuterated fluoxetine as internal standard. | Fluoxetine (F) and its N-demehylated metabolite norfluoxetine (NF) are selective inhibitors of serotonin reuptake in humans. A new sensitive rapid method for the simultaneous determination of F and NF in plasma was established and validated, and was further applied to assess the bioequivalence of two oral formulations ... | Train | 3 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | [
1,
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0,
1,
1,
1,
1,
0
] | 187 |
31,469,752 | Fascia Iliaca Block Decreases Hip Fracture Postoperative Opioid Consumption: A Prospective Randomized Controlled Trial. | To determine the efficacy of a preoperative fascia iliaca compartment block in decreasing postoperative pain and improving functional recovery after hip fracture surgery. Randomized prospective Level 1 therapeutic. Academic Level 1 trauma center. Geriatric patients with fractures of the proximal femur (neck, intertroch... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | [
1,
1,
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1,
1,
1,
1
] | 188 |
31,896,491 | Fluoxetine for motor recovery after acute intracerebral hemorrhage, the FMRICH trial. | Acute intracerebral hemorrhage (ICH) is a very common cause of disability. Previous evidence suggests that fluoxetine and other selective serotonin reuptake inhibitors improve, the recovery of motor function in patients with cerebral infarct. The purpose of this study was to investigate whether fluoxetine also improves... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | [
1,
1,
1,
1,
1,
1,
1,
1
] | 189 |
10,632,645 | Does eradication of Helicobacter pylori alone heal duodenal ulcers? | Eradication of Helicobacter pylori infection prevents duodenal ulcer (DU) relapse, but it remains uncertain whether eradication of H. pylori alone heals duodenal ulceration. To test the hypothesis that eradication of H. pylori infection is accompanied by healing of duodenal ulcer. A total of 115 consecutive patients wi... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | [
1,
1,
1,
1,
1,
1,
1,
1
] | 190 |
12,657,482 | [Pharmacological treatment of post-traumatic behavioural disorders]. | Literature review of the data concerning pharmacologic treatment of post-traumatic behavioural disorders. This review is limited to the treatment of agitation, excitation, mood lability, hostility and agressivity as defined by the NRS and excludes pharmacologic treatment of mental slowness, cognitive disorders and depr... | Train | 3 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | [
1,
0,
1,
0,
0,
1,
1,
0
] | 191 |
11,392,571 | Ex-vivo product performance of Diskus and Turbuhaler inhalers using inhalation profiles from patients with severe chronic obstructive pulmonary disease. | Dosing performance of dry powder inhalers is dependent on patient's inspiratory effort. This study compares the inhalation profiles generated by patients with severe obstructive lung disease using Diskus and Turbuhaler inhalers. The patient profiles are subsequently used to determine the dosing performance of fluticaso... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | [
1,
1,
1,
1,
1,
1,
0,
0
] | 192 |
21,703,636 | Benefits and risks of using clopidogrel before coronary artery bypass surgery: systematic review and meta-analysis of randomized trials and observational studies. | The benefits and risks associated with the use of clopidogrel before coronary artery bypass grafting are controversial, and these were investigated in the present meta-analysis. A systematic literature search was performed to identify studies on the use of clopidogrel before coronary artery bypass grafting. Meta-analys... | Train | 3 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | [
1,
1,
1,
0,
1,
1,
1,
0
] | 194 |
2,474,109 | An open multicenter study to assess the long-term efficacy, tolerance, and safety of the oral angiotensin converting enzyme inhibitor ramipril in patients with mild to moderate essential hypertension. | Three hundred thirty-one patients with mild to moderate essential hypertension, 182 males and 149 females with a mean age of 54 (range, 17-87 years), were studied for 1 year in a clinical trial with ramipril, an angiotensin converting enzyme (ACE) inhibitor. The patients included had completed double-blind trials with ... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | [
1,
1,
1,
1,
1,
1,
1,
0
] | 195 |
15,381,643 | Prognostic impact of plasma N-terminal pro-brain natriuretic peptide in severe chronic congestive heart failure: a substudy of the Carvedilol Prospective Randomized Cumulative Survival (COPERNICUS) trial. | The utility of N-terminal proBNP (NT-proBNP) to predict the occurrence of death and hospitalization was prospectively evaluated in the COPERNICUS study, which enrolled patients with an ejection fraction <25% and symptoms of chronic congestive heart failure at rest or on minimal exertion. Baseline plasma concentrations ... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | [
1,
1,
1,
1,
1,
1,
1,
1
] | 196 |
30,429,431 | Specialty-Related Differences in the Acute-Phase Treatment and Prognosis in Patients With Acute Heart Failure - Insights From REALITY-AHF. | The aim of this study was to assess specialty-related differences in the treatment for patients with acute heart failure (AHF) in the acute phase and subsequent prognostic differences. Methods and Results: We analyzed hospitalizations for AHF in REALITY-AHF, a multicenter prospective registry focused on very early pres... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | [
1,
1,
1,
1,
1,
1,
1,
1
] | 197 |
29,321,548 | Role and mechanism of AT1-AA in the pathogenesis of HELLP syndrome. | HELLP syndrome remains a leading cause of maternal and neonatal mortality and morbidity worldwide, which symptoms include hemolysis, elevated liver enzymes and low platelet count. The objective of this study was to determine whether HELLP is associated with AT1-AA. The positive rate and titer of AT1-AA in plasma from p... | Train | 3 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | [
1,
0,
1,
1,
0,
1,
0,
0
] | 200 |
26,452,405 | Comparison of the efficacy of culture-based tailored therapy for Helicobacter pylori eradication with that of the traditional second-line rescue therapy in Korean patients: a prospective single tertiary center study. | The effectiveness of Helicobacter pylori therapies has declined with an increase in antibiotic resistance. To overcome this problem, the efficacy of tailored H. pylori eradication therapy based on antimicrobial susceptibility testing was compared with that of empirical second-line rescue regimens. Patients who had pers... | Train | 3 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | [
1,
1,
0,
0,
1,
0,
1,
0
] | 201 |
14,556,543 | [Use of omeprazole and esomeprazole in patients suffering from bronchial asthma with associated gastroesophageal reflux disease]. | The purpose of this study is a comparative assessment of the clinical efficiency of Omeprazole and Esomeprazole in patients suffering from bronchial asthma (BA) with associated gastroesophageal reflux disease (GERD). 101 patients with BA and associated GERD being under study were divided into three groups depending on ... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | [
1,
1,
1,
1,
1,
1,
1,
1
] | 202 |
29,512,177 | Patterns and profiles of methylphenidate use both in children and adults. | The aim of the present study was to characterize patterns of use of methylphenidate (MPH), a prescription stimulant medication recommended in the treatment of attention deficit hyperactivity disorder (ADHD) and of narcolepsy, in France, both in children and adults, over a 3-year period. Using the French General Health ... | Train | 3 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | [
1,
1,
1,
1,
0,
1,
1,
0
] | 203 |
14,604,304 | Effect of inhalation of salbutamol, beclomethasone dipropionate & ipratropium bromide on mucociliary clearance in some patients with chronic stable bronchial asthma. | Asthma is now regarded as an inflammatory disease and bronchial inflammation may disrupt mucociliary function. Inhaled drugs may act by improving mucociliary function. The aim of the study was to investigate the effect of salbutamol, ipratropium bromide and beclomethasone on mucociliary clearance in patients with chron... | Train | 3 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | [
1,
1,
1,
1,
0,
1,
1,
1
] | 204 |
29,802,627 | Comparative evaluation of subgingivally delivered 1.2% rosuvastatin and 1% metformin gel in treatment of intrabony defects in chronic periodontitis: A randomized controlled clinical trial. | The aim of this study is to explore and compare the clinical efficacy of locally delivered 1.2% Rosuvastatin (RSV) and 1% Metformin (MF) gel as an adjunct to scaling and root planning (SRP) in the treatment of intrabony defects in chronic periodontitis patients. A total of 90 volunteers were randomly assigned to three ... | Train | 3 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | [
1,
1,
1,
1,
0,
1,
1,
1
] | 205 |
33,893,087 | Aspirin in Hepatocellular Carcinoma. | Preclinical and clinical studies provide evidence for aspirin as a preventative agent for cancer. Compelling direct evidence supports a chemopreventive effect of aspirin in individuals at high risk of developing colorectal cancer due to Lynch syndrome, while indirect evidence indicates that aspirin may reduce the risk ... | Train | 3 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | [
1,
0,
1,
1,
0,
1,
0,
0
] | 206 |
8,682,134 | Effects of metoprolol vs verapamil in patients with stable angina pectoris. The Angina Prognosis Study in Stockholm (APSIS) | To study long-term treatment effects of metoprolol or verapamil on combined cardiovascular end points and psychological variables in patients with stable angina pectoris. Randomized, double-blind, double-dummy trial. The study included 809 patients under 70 years of age with stable angina pectoris. The mean age of the ... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | [
1,
1,
1,
1,
1,
1,
1,
1
] | 207 |
7,272,956 | Osteonecrosis in patients with malignant lymphoma: a review of twenty-five cases. | A retrospective study of 25 patients with malignant lymphoma who had osteonecrosis of either the femoral or humeral head(s) was undertaken. The common factor present among all patients was the administration of intermittent steroid-containing combination chemotherapy. Seventeen Hodgkin's disease patients received chemo... | Train | 3 | 1 | 1 | 1 | 0 | 0 | 1 | 1 | 0 | [
1,
1,
1,
0,
0,
1,
1,
0
] | 208 |
8,510,088 | Double-blind controlled study of rilmenidine versus hydrochlorothiazide in mild hypertension: clinical and renal haemodynamic evaluation. | Clinical and renal haemodynamic parameters were evaluated in 20 mild hypertensive patients after rilmenidine (RIL) administration during a one month double-blind randomised study compared with hydrochlorothiazide (HCT). At the beginning and at the end of the study, BP, heart rate and renal haemodynamic parameters were ... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | [
1,
1,
1,
1,
1,
1,
1,
1
] | 209 |
32,316,515 | Interindividual Variability of Apixaban Plasma Concentrations: Influence of Clinical and Genetic Factors in a Real-Life Cohort of Atrial Fibrillation Patients. | (1) Background: Prescribing apixaban for stroke prevention has significantly increased in patients with non-valvular atrial fibrillation (NVAF). The <i>ABCB<sub>1</sub></i> genotype can influence apixaban absorption and bioavailability. The aim of the present study was to assess the factors that influence apixaban's pl... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | [
1,
1,
1,
1,
1,
1,
1,
0
] | 210 |
18,403,218 | Switching from pathogenetic treatment with alpha-lipoic acid to gabapentin and other analgesics in painful diabetic neuropathy: a real-world study in outpatients. | In this retrospective real-world study, we aimed to evaluate whether switching from the pathogenetic treatment option alpha-lipoic acid to drugs for symptomatic treatment of neuropathic pain such as gabapentin would be associated with changes in efficacy, safety, and cost-effectiveness. A cohort of 443 diabetic patient... | Train | 3 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | [
1,
1,
1,
1,
0,
1,
1,
0
] | 211 |
17,942,015 | Dexamphetamine boosts naming treatment effects in chronic aphasia. | To date, minimal research has investigated the effect of combining dexamphetamine with standard naming therapy after stroke. The present study used a double-blind, placebo-controlled, multiple baseline, crossover design with two individuals in the chronic stage of stroke recovery. Each individual attended two 4-week bl... | Train | 3 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | [
1,
1,
1,
1,
0,
1,
1,
1
] | 212 |
32,464,225 | Heart Rate and Heart Rate Difference Predicted the Efficacy of Metoprolol on Postural Tachycardia Syndrome in Children and Adolescents. | To evaluate the ability of heart rate (HR) and HR difference during head-up tilt test (HUTT) and to predict clinical improvement related to metoprolol treatment in children and adolescents with postural tachycardia syndrome (POTS). This was a retrospective cohort study. A total of 53 subjects (27 male, aged 6-12 years ... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | [
1,
1,
1,
1,
1,
1,
1,
1
] | 213 |
10,622,623 | Clinical follow-up examination after treatment of canine leishmaniasis. | In 16 dogs, the diagnosis of canine leishmaniasis could be detected by direct microscopic identification, by determination of the antibody titre or by PCR method (peripheral blood/bone marrow). On the basis of the clinical and laboratory diagnostic results 9 cases of the cutaneous type and 7 dogs of the combined cutane... | Train | 3 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | [
1,
0,
1,
1,
0,
1,
1,
0
] | 215 |
16,096,702 | Phase I and pharmacokinetic study of docetaxel, irinotecan, and celecoxib in patients with advanced non-small cell lung cancer. | We studied the toxicities, potential pharmacokinetic interactions, and preliminary antitumor activity of the combination of docetaxel and irinotecan with celecoxib, a selective cyclooxygenase-2 inhibitor. Eligible patients had advanced non-small lung cancer (NSCLC) with measurable disease, good performance status, and ... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | [
1,
1,
1,
1,
1,
1,
1,
0
] | 216 |
27,655,469 | Predictors of Neurological Outcome of Tuberculous Meningitis in Childhood: A Prospective Cohort Study From a Developing Country. | To assess the long-term outcome of childhood tuberculous meningitis treated with modern 4-drug antitubercular regimens and to determine predictors of survival and morbidity. In this single-center prospective cohort, outcome of children with tuberculous meningitis treated with standard regimens was assessed at 6 months ... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | [
1,
1,
1,
1,
1,
1,
1,
0
] | 218 |
34,535,015 | Initial therapy for chronic graft-versus-host disease: analysis of practice variation and failure-free survival. | Prior clinical trials largely considered prednisone 1 mg/kg per day with or without calcineurin inhibitor as standard initial therapy for chronic graft-versus-host disease (cGVHD), but uncertainty remains regarding the extent of practice variation and whether this affects subsequent outcomes. We assembled a cohort of 7... | Train | 3 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | [
1,
1,
1,
1,
0,
1,
1,
1
] | 220 |
29,433,578 | Resistant Hypertension On Treatment (ResHypOT): sequential nephron blockade compared to dual blockade of the renin-angiotensin-aldosterone system plus bisoprolol in the treatment of resistant arterial hypertension - study protocol for a randomized controlled trial. | Resistant hypertension is characterized when the blood pressure (BP) remains above the recommended goal after taking three antihypertensive drugs with synergistic actions at their maximum recommended tolerated doses, preferably including a diuretic. Identifying the contribution of intravascular volume and serum renin i... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | [
1,
1,
1,
1,
1,
1,
1,
0
] | 221 |
1,826,071 | Left ventricular hypertrophy in elderly hypertensive patients: a report from the European Working Party on High Blood Pressure in the Elderly trial. | In a double-blind, placebo-controlled trial, 840 elderly hypertensive patients were randomly assigned to treatment with a combination of hydrochlorothiazide and triamterene or placebo; methyldopa or matching placebo was added to the treatment regimen if blood pressures remained high. After adjustment for age, gender, a... | Train | 3 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | [
1,
1,
1,
1,
0,
1,
1,
1
] | 223 |
10,938,493 | Effects of high-dose furosemide and small-volume hypertonic saline solution infusion in comparison with a high dose of furosemide as a bolus, in refractory congestive heart failure. | Diuretics, have been accepted as first-line treatment in refractory heart failure, but a lack of response is a frequent event. A randomised single blind study was performed to evaluate the effects of the combination of high-dose furosemide and small-volume hypertonic saline solution (HSS) infusion in the treatment of r... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | [
1,
1,
1,
1,
1,
1,
1,
1
] | 224 |
35,279,338 | Prospective Randomized Study Using Pharmacogenetics to Customize Postoperative Pain Medication Following Hip and Knee Arthroplasty. | The purpose of this study is to determine whether pharmacogenetic testing could be used to effectively customize postoperative pain medicine following total joint replacement. Buccal swabs were collected preoperatively from 107 patients. Pharmacogenetic testing was performed for genetic variants on a panel of 16 genes,... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | [
1,
1,
1,
1,
1,
1,
1,
1
] | 225 |
15,209,479 | Costs of antidepressant medications associated with inadequate treatment. | To determine the costs of antidepressant medications used during inadequate treatment. Retrospective database analysis of pharmacy claims made by patients who were treated under routine clinical conditions from July 1, 1999, through September 30, 2002. Our participants included 21,632 patients enrolled in a commercial ... | Train | 3 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | [
1,
1,
1,
1,
0,
1,
1,
0
] | 226 |
10,654,204 | Bronchodilator delivery by metered-dose inhaler in mechanically ventilated COPD patients: influence of tidal volume. | The delivery of bronchodilator drugs with metered-dose inhaler (MDI) and a spacer in mechanically ventilated patients has become a widespread practice. However, the various ventilator settings that influence the efficacy of MDI are not well established. The tidal volume (VT) during drug delivery has been suggested as o... | Train | 3 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | [
1,
1,
1,
1,
0,
1,
1,
1
] | 227 |
9,173,668 | [Maintenance therapy with 20 mg fluoxetine. Results of an administration study of 1,737 depressed patients]. | An application study was carried out in 1993/94 on the use of fluoxetine for the continuation therapy of depression. 1737 patients received fluoxetine at a dosage of 20 mg per day over a period of 6 months. Diagnosis was made by clinical evaluation of phenomenology and ICD-10 classification. Over the observation period... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | [
1,
1,
1,
1,
1,
1,
1,
0
] | 229 |
21,877,765 | Effect of fluoxetine on the pharmacokinetics of lansoprazole: a two-treatment period study in healthy male subjects. | Fluoxetine is an inhibitor of the main metabolizing enzymes of lansoprazole and could influence the pharmacokinetics of lansoprazole. The changes in lansoprazole pharmacokinetics could have clinical significance concerning the safety of the therapy. The aim of this study was to evaluate the pharmacokinetic interaction ... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | [
1,
1,
1,
1,
1,
1,
1,
1
] | 230 |
34,729,920 | Rituximab exposure-response in triweekly R-CHOP treatment in DLBCL: A loading dose is recommended to improve clinical outcomes. | Previous exposure-response analyses for rituximab suggest that higher rituximab concentrations were associated with an improvement in efficacy, however, clinical studies investigating a higher rituximab dose had mixed results. To further explore the exposure-response relationship of rituximab, a prospective observation... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | [
1,
1,
1,
1,
1,
1,
1,
0
] | 231 |
20,302,588 | Bismuth-containing quadruple therapy as second-line treatment for Helicobacter pylori infection: effect of treatment duration and antibiotic resistance on the eradication rate in Korea. | The eradication rate of first-line Helicobacter pylori treatment is only 70-85% and has been decreasing due to the increase in antibiotic resistance. The aim of this study was to evaluate the efficacy of bismuth-containing quadruple therapy as second-line treatment for H. pylori infection based on treatment duration. W... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | [
1,
1,
1,
1,
1,
1,
1,
0
] | 232 |
7,951,343 | Double-blind study with dipyrone versus tramadol and butylscopolamine in acute renal colic pain. | To investigate the combined analgesic and spasmolytic effect of dipyrone, 104 patients suffering from "severe" or "excruciating" colic pain due to a confirmed calculus in the upper urinary tract were randomized to receive i.v. either 2.5 g dipyrone (36 patients), 100 mg tramadol (35 patients), or 20 mg butylscopolamine... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | [
1,
1,
1,
1,
1,
1,
1,
1
] | 233 |
31,387,895 | Effect of Oxygen Flow on Aerosol Delivery From a Nebulizer With a Holding Chamber. | A new holding chamber was designed to be used with a vibrating mesh nebulizer to increase the total inhalable dose for patients. It facilitates intermittent and continuous nebulization as well as the optional supply of supplemental oxygen via a T-piece with a mouthpiece adapter. This study aimed to evaluate the effect ... | Train | 3 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | [
1,
1,
1,
0,
1,
1,
1,
0
] | 234 |
23,045,592 | Stage-adapted treatment of HIV-associated Hodgkin lymphoma: results of a prospective multicenter study. | Although the outcome of patients with HIV-related Hodgkin lymphoma (HIV-HL) has markedly improved since the introduction of combined antiretroviral therapy, standard therapy is still poorly defined. This prospective study investigates a stage- and risk-adapted treatment strategy in patients with HIV-HL. Patients with e... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | [
1,
1,
1,
1,
1,
1,
1,
1
] | 235 |
12,036,194 | Carvedilol does not modulate moderate exercise-induced hyperkalemia in hemodialysis patients. | Non-selective beta-adrenergic blockers may cause hyperkalemia in patients with end-stage renal failure. In contrast, alpha-adrenergic blockade has been found to decrease the hyperkalemic effect of physical exercise in healthy subjects, although we were unable to confirm this effect in hemodialysis patients. In a crosso... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | [
1,
1,
1,
1,
1,
1,
1,
1
] | 236 |
20,015,242 | Activity and safety of combination chemotherapy with methotrexate, ifosfamide, l-asparaginase and dexamethasone (MILD) for refractory lymphoid malignancies: a pilot study. | Optimal salvage chemotherapy has not been established for lymphoid malignancy, which is refractory to the conventional cyclophosphamide, doxorubicin, vincristine, and prednisone regimen. To explore an effective regimen, we conducted a phase I pilot study of combination chemotherapy with methotrexate, ifosfamide, l-aspa... | Train | 3 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | [
1,
1,
1,
1,
0,
1,
1,
0
] | 237 |
20,469,785 | Efficacy of low dose atorvastatin in diabetic dyslipidaemia. | Coronary heart disease (CHD), the commonest cause of morbidity and mortality in patients with type 2 diabetes, requires multipronged approach for management, including especially treating dyslipidaemia with statins. We conducted this study to demonstrate that low dose (10 mg) atorvastatin is effective in reducing LDL c... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | [
1,
1,
1,
1,
1,
1,
1,
0
] | 239 |
28,716,642 | Long-term Use of Inhaled Corticosteroids in COPD and the Risk of Fracture. | It is uncertain whether long-term use of inhaled corticosteroids (ICSs), widely used to treat COPD, increases the risk of fracture, particularly in women, in view of the postmenopausal risks. We assessed whether long-term ICS use in patients with COPD increases the risk of hip or upper extremity fractures, and examined... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | [
1,
1,
1,
1,
1,
1,
1,
1
] | 240 |
18,840,377 | Direct hospital resource utilization and costs of treating patients with multiple myeloma in Southwest Sweden: a 5-year retrospective analysis. | Approximately 570 patients are diagnosed with multiple myeloma (MM) in Sweden each year. Few studies have estimated the cost of treatment for these patients. The purpose of this study was to retrospectively investigate the direct hospital resource utilization and costs associated with the treatment of patients with MM ... | Train | 3 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | [
1,
0,
1,
0,
0,
0,
1,
0
] | 241 |
9,330,414 | Growth during one year of treatment with fluticasone propionate or sodium cromoglycate in children with asthma. | The aim of this study was to compare accurately measured growth over 12 months in asthmatic children treated with either fluticasone propionate (FP) 50 micrograms twice daily (b.i.d.) or sodium cromoglycate (SCG) 20 mg four times daily (q.i.d.). After a 2-week run-in, asthmatic children aged 4-10 years from 15 UK cente... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | [
1,
1,
1,
1,
1,
1,
1,
1
] | 242 |
16,687,625 | Safety and efficacy of a calcineurin inhibitor avoidance regimen in pediatric renal transplantation. | Thirty-four children were entered into a pilot trial of calcineurin inhibitor avoidance after living-donor kidney transplantation, the CN-01 study. Patients were treated with anti-CD25 mAb, prednisone, mycophenolate mofetil, and sirolimus. Twenty patients were maintained on the protocol for up to 3 yr of follow-up. One... | Train | 3 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | [
1,
1,
1,
1,
0,
1,
1,
1
] | 244 |
26,091,447 | Combination Therapy of Metformin and Statin May Decrease Hepatocellular Carcinoma Among Diabetic Patients in Asia. | Previous studies have shown that metformin or statins may decrease hepatocellular carcinoma (HCC) in diabetic patients. Accordingly, this article evaluates whether combination therapy may further reduce HCC. Newly diagnosed type 2 diabetes mellitus (DM) patients, excluding those with history of malignancy prior to the ... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | [
1,
1,
1,
1,
1,
1,
0,
0
] | 245 |
29,898,002 | QTc interval prolongation in critically ill patients: Prevalence, risk factors and associated medications. | To investigate the prevalence and risk factors of acquired long QT syndrome (LQTS) on admission to a general Intensive Care Unit (ICU), and to assess the risk of LQTS associated with prescribed medications. Prospective observational, cross-sectional study approved by the Institutional Review Board. Between May 2014 and... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | [
1,
1,
1,
1,
1,
1,
1,
0
] | 246 |
9,746,123 | Different effects of nifedipine and amlodipine on circulating catecholamine levels in essential hypertensive patients. | To compare the acute and chronic effects of nifedipine retard (NPA), nifedipine gastrointestinal therapeutic system (NGITS) and amlodipine at trough and peak plasma concentrations of drug on blood pressure and heart rate, and on plasma norepinephrine and epinephrine levels in patients with mild-to-moderate hypertension... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | [
1,
1,
1,
1,
1,
1,
1,
1
] | 247 |
23,538,479 | Anterior chamber bleeding after laser peripheral iridotomy. | To our knowledge, this is the first study to describe the correlation of anterior chamber bleeding after laser peripheral iridotomy (LPI) and antiplatelet therapy. To determine the incidence and amount of anterior chamber bleeding after laser peripheral iridotomy in patients whose condition is suggestive of primary ang... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | [
1,
1,
1,
1,
1,
0,
1,
0
] | 248 |
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