PMID int64 2.09k 36.2M | Title stringlengths 21 414 | Abstract stringlengths 175 8.83k | Split stringclasses 1
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15,899,079 | Treatment failure of vaginal trichomoniasis in clinical practice. | We have conducted a retrospective study of treatment failure of Trichomonas vaginalis (TV) infection in a busy, urban genitourinary medicine clinic in Birmingham, UK, between 1998 and 2002. The prevalence of non-response to standard doses of metronidazole without any history of reinfection or nonadherence was 1.7% (28/... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | [
1,
1,
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1,
1,
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1,
0
] | 366 |
11,060,527 | The clinical course of immune thrombocytopenic purpura in children who did not receive intravenous immunoglobulins or sustained prednisone treatment. | To demonstrate the result of watchful waiting without specific therapy in unselected children with acute immune thrombocytopenic purpura (ITP). Between May 1992 and October 1999, 55 consecutive children (aged 2 months to 16 years; 28 boys and 27 girls) with acute ITP did not receive intravenously administered immune gl... | Train | 3 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | [
1,
1,
1,
1,
0,
1,
1,
1
] | 368 |
18,466,416 | Tolerability of high doses of lercanidipine versus high doses of other dihydropyridines in daily clinical practice: the TOLERANCE Study. | The TOLERANCE study was aimed to compare the tolerability of high doses of lercanidipine (20 mg) with that of other frequently used dihydropyridines (amlodipine 10 mg/nifedipine GITS 60 mg) in the treatment of essential hypertension in daily clinical practice. It was an observational, transversal, multicentre study per... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | [
1,
1,
1,
1,
1,
1,
1,
1
] | 369 |
22,548,767 | Efficacy of omeprazole, famotidine, mosapride and teprenone in patients with upper gastrointestinal symptoms: an omeprazole-controlled randomized study (J-FOCUS). | In Japan, treatment guidelines are lacking for patients with upper gastrointestinal symptoms. We aimed to compare the efficacy of different drugs for the treatment of uninvestigated upper gastrointestinal symptoms. This was a randomized, open-label, parallel-group multicenter study. Helicobacter pylori-negative, endosc... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | [
1,
1,
1,
1,
1,
1,
1,
0
] | 370 |
11,134,196 | Flutamide versus prednisone in patients with prostate cancer symptomatically progressing after androgen-ablative therapy: a phase III study of the European organization for research and treatment of cancer genitourinary group. | Time to progression (TTP), overall survival, and quality of life (QL) were compared in patients with hormone-resistant prostate cancer (HRPC) treated with prednisone (5 mg orally, four times a day) or flutamide (250 mg orally, three times a day). Symptomatic patients were randomized to receive either prednisone (101 pa... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | [
1,
1,
1,
1,
1,
1,
1,
1
] | 372 |
3,767,347 | Cefuroxime axetil for treatment of uncomplicated gonorrhea. | Oral cefuroxime axetil (1 g) plus probenecid cured 29 of 30 urethral and 6 of 6 rectal gonococcal infections in men; alone the drug cured 22 of 23 urethral and 4 of 6 rectal infections. No toxicity was observed. Cefuroxime axetil alone is effective for urethral gonorrhea in males; rectal gonorrhea probably requires add... | Train | 3 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | [
1,
1,
1,
1,
0,
1,
1,
0
] | 374 |
32,173,269 | Radiation-induced lung toxicity predictors: Retrospective analysis of 90 patients treated with stereotactic body radiation therapy for stage I non-small-cell lung carcinoma. | The main complication after hypofractionated radiotherapy for lung carcinoma is radiation-induced lung toxicity, which can be divided into radiation pneumonitis (acute toxicity, occurring within 6 months) and lung fibrosis (late toxicity, occurring after 6 months). The literature describes several predictive factors re... | Train | 3 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | [
1,
1,
1,
1,
0,
1,
1,
0
] | 375 |
8,357,297 | Plasma alprazolam concentrations. Relation to efficacy and side effects in the treatment of panic disorder. | A series of 237 patients with DSM-III-diagnosed panic disorder, or agoraphobia with panic attacks, received alprazolam as part of the placebo-controlled Cross-National Collaborative Panic Study. After a 1-week drug-free period, alprazolam dosage was titrated upward with the objective of reaching 6.0 mg/d in all patient... | Train | 3 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | [
1,
1,
1,
1,
0,
1,
1,
1
] | 377 |
17,178,181 | Gabapentin's acute effect on mood profile -- a controlled study on patients with alcohol withdrawal. | Delayed beneficial effects of gabapentin on mood were frequently reported in various patient populations. This is the first controlled study which addressed acute effects of gabapentin on mood. Analysis of the German version of Profile of Mood States (POMS) throughout a randomised placebo-controlled, double-blinded stu... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | [
1,
1,
1,
1,
1,
1,
1,
1
] | 379 |
10,450,615 | Psychological versus pharmacological treatments of bulimia nervosa: predictors and processes of change. | This article extends the acute outcome findings from a study comparing psychological and pharmacological interventions for bulimia nervosa (B.T. Walsh et al., 1997) by examining 3 additional domains: predictive factors, therapeutic alliance, and time course of change. One hundred twenty women were randomized to cogniti... | Train | 3 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | [
1,
1,
1,
1,
0,
1,
1,
1
] | 380 |
2,090,833 | Concomitant considerations in long-term antihypertensive treatment. | Even with antihypertensive therapy, the risks in hypertensive patients, especially the incidence of coronary events, cannot be lowered to that of the normotensive population. Therefore, the metabolic effects of long-term therapy on lipid metabolism and the efficacy of antihypertensive drugs to lower blood pressure were... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | [
1,
1,
1,
1,
1,
1,
0,
0
] | 382 |
11,548,448 | [Effects of the long-term treatment with losartan and captopril and of the abrupt cessation on circadian blood pressure profile]. | The influence of a long-term treatment with losartan (50-100 mg o.d.) and captopril (25-50 mg b.i.d.) followed by the abrupt therapy cessation was studied in an open randomized placebo-controlled parallel group trial. The study was performed on a group of 22 essential (soft to moderate) hypertensive male patients, whic... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | [
1,
1,
1,
1,
1,
1,
1,
1
] | 383 |
18,763,589 | [Efficacy of conservative treatment of gastric lymphosarcoma]. | To compare efficacy and toxicity of conservative therapy (different programs of polychemotherapy) of gastric lymphosarcoma conducted for the last 10 years in Hematological Research Center of the Russian Academy of Medical Sciences. The study included 63 patients (40 females and 23 males aged 14 to 78 years, mean age 49... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | [
1,
1,
1,
1,
1,
1,
1,
1
] | 384 |
2,948,430 | Salbutamol and ipratropium bromide solution in the treatment of bronchospasm in asthmatic children. | The effects of the beta 2-adrenergic agonist salbutamol (0.02 mL/kg of a 0.5% solution) and the cholinergic antagonist ipratropium bromide (2 mL of a 0.025% solution), administered alone or in combination at different doses, were evaluated in 48 asthmatic children using a single-dose, double-blind, crossover design. Sp... | Train | 3 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | [
1,
1,
1,
1,
0,
1,
1,
0
] | 385 |
10,500,060 | Antibiotic efficacy in small intestinal bacterial overgrowth-related chronic diarrhea: a crossover, randomized trial. | No controlled trial has examined the clinical efficacy of antibiotics in small bowel bacterial overgrowth. Ten patients with bacterial overgrowth-related diarrhea underwent the following five 7-day treatment periods: untreated (control period), then placebo, and subsequently, in random order and blinded fashion, norflo... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | [
1,
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1,
1,
1,
1,
1
] | 386 |
10,984,808 | Cyclosporine-drug interactions and the influence of patient age. | Cyclosporine-drug interactions in adult transplant patients and the impact of age were studied. The medical records of transplant patients receiving cyclosporine therapy were identified. Data on patient demographics, cyclosporine dosages, dosage form, blood trough concentrations, clinical laboratory test values, and co... | Train | 3 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | [
1,
1,
1,
1,
0,
1,
1,
0
] | 387 |
12,659,988 | Effects of statin on plaque stability and thrombogenicity in hypercholesterolemic patients with coronary artery disease. | Plaque stability and thrombogenicity contribute to development and clinical expression of atherosclerosis. Experimental studies have shown that lipoproteins or mevalonate regulate matrix metalloproteinase (MMP)-9, tissue factor (TF), plasminogen activator inhibitor-1 (PAI-1) expression, providing nonlipid mechanism. We... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | [
1,
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1,
1,
1,
1,
1,
0
] | 389 |
15,522,468 | Antiplatelet effects of a 600 mg loading dose of clopidogrel are not attenuated in patients receiving atorvastatin or simvastatin for at least 4 weeks prior to coronary artery stenting. | To test prospectively whether the antiplatelet effect of a 600 mg loading dose of clopidogrel is attenuated in patients receiving atorvastatin and simvastatin for at least 4 weeks prior to coronary artery stenting. Blood samples were obtained at least 2 h after receiving 100 mg aspirin and 600 mg clopidogrel and prior ... | Train | 3 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | [
1,
1,
1,
1,
0,
1,
1,
1
] | 390 |
30,279,015 | BOXIT-A Randomised Phase III Placebo-controlled Trial Evaluating the Addition of Celecoxib to Standard Treatment of Transitional Cell Carcinoma of the Bladder (CRUK/07/004). | Non-muscle-invasive bladder cancer (NMIBC) has a significant risk of recurrence despite adjuvant intravesical therapy. To determine whether celecoxib, a cyclo-oxygenase 2 inhibitor, reduces the risk of recurrence in NMIBC patients receiving standard treatment. BOXIT (CRUK/07/004, ISRCTN84681538) is a double-blinded, ph... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | [
1,
1,
1,
1,
1,
1,
1,
1
] | 392 |
17,762,711 | Citalopram modulation of neuronal responses to aversive face emotions: a functional MRI study. | This study investigated the serotonergic modulation of face emotion processing using blood oxygen level-dependent (BOLD) functional MRI. In a placebo-controlled, balanced order design, intravenous citalopram (7.5 mg) was given to 12 male volunteers 60 min before a covert face emotion recognition task. Angry, disgusted ... | Train | 3 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 1 | [
1,
1,
0,
1,
0,
1,
1,
1
] | 394 |
18,593,517 | Efficacy and tolerability of combination therapy with valsartan/hydrochlorothiazide in the initial treatment of severe hypertension. | Most patients with severe hypertension are at high risk for cardiovascular events and require prompt blood pressure (BP)-lowering and combination therapy to achieve BP goals. This study evaluated the therapeutic efficacy and tolerability of initial treatment with the combination of valsartan and hydrochlorothiazide (HC... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | [
1,
1,
1,
1,
1,
1,
1,
1
] | 395 |
9,690,573 | Efficacy of salmeterol xinafoate powder in children with chronic persistent asthma. | The efficacy and safety of salmeterol powder have not previously been evaluated in children with asthma in the United States. The efficacy and safety of salmeterol powder versus placebo were compared in children between the ages of 4 and 11 years with chronic persistent asthma. A randomized, double-blind, placebo-contr... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | [
1,
1,
1,
1,
1,
1,
1,
1
] | 396 |
23,176,189 | A valved holding chamber does not decrease the bronchodilator activity of budesonide-formoterol combination metered dose inhaler. | Spacers and valved holding chambers (VHCs) were developed to facilitate using pressurized metered dose inhaler (pMDI) by patients who could not coordinate the actions required for successful pMDI use. There is little in vivo evidence about how VHC may affect the bronchodilation from combination drugs in pMDI. This stud... | Train | 3 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | [
1,
1,
1,
1,
0,
1,
1,
1
] | 398 |
12,621,161 | Preventing angiographic progression of coronary atherosclerosis with pravastatin. | We conducted a prospective study to investigate the relationship between the decrease of serum lipid levels during pravastatin therapy and changes of coronary angiography parameters in Japanese patients with coronary atherosclerosis. The patients were predominantly male, aged between 18 and 75 years (mean: 58 years), h... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | [
1,
1,
1,
1,
1,
1,
1,
0
] | 399 |
8,105,910 | Treatment of end-stage renal disease due to lupus nephritis: comparison of six patients treated with both peritoneal and hemodialysis. | End-stage renal disease (ESRD) is one of the most significant complications of systemic lupus erythematosus (SLE). Previous investigators have evaluated the morbidity and mortality of different renal replacement treatment modalities in these patients. Earlier reports have suggested that the systemic manifestations of S... | Train | 3 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | [
1,
1,
1,
1,
0,
1,
1,
0
] | 400 |
12,772,798 | Nodular gastritis in adults is caused by Helicobacter pylori infection. | A close relationship exists between nodular gastritis and Helicobacter pylori infection in children. The pathogenesis and optimal management of nodular gastritis in adults, however, are unclear. This study describes the clinicopathologic features of nodular gastritis in adults and correlates treatment with outcome. Of ... | Train | 3 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | [
1,
1,
1,
1,
0,
0,
1,
0
] | 401 |
27,863,333 | Serum biomarkers of inflammation and muscle strength among women with systemic lupus erythematosus. | Muscle strength is an important determinant of physical function in women with systemic lupus erythematosus (SLE). Serum biomarkers of inflammation, including interleukin-6 (IL-6) and C-Reactive Protein (CRP), are associated with differences in muscle strength among individuals without rheumatologic disease. We examine... | Train | 3 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | [
1,
1,
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1,
0,
0,
1,
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] | 402 |
9,058,634 | Twenty-four-hour monitoring of intragastric acidity: comparison between lansoprazole 30mg and pantoprazole 40mg. | To date, there is no published study, comparing the effects of lansoprazole and pantoprazole on gastric acid secretion inhibition. The aim of this study, was to compare the effects of these two drugs on 24-h intragastric pH-metry. Twelve healthy volunteers were included in an open, randomized, crossover study. Each sub... | Train | 3 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | [
1,
1,
1,
1,
0,
1,
1,
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] | 404 |
26,580,072 | Helicobacter pylori Eradication Prevents Metachronous Gastric Neoplasms after Endoscopic Resection of Gastric Dysplasia. | There is insufficient data about the role of eradication of H. pylori after endoscopic resection (ER) for gastric dysplasia. The aim was to investigate the benefit of H. pylori eradication after ER in patients with gastric dysplasia to prevent metachronous gastric neoplasms. We retrospectively reviewed 1872 patients wh... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | [
1,
1,
1,
1,
1,
0,
1,
0
] | 405 |
788,738 | Comparison of salmefamol and salbutamol in patients with chronic airways obstruction. | 1 Inhaled salmefamol, in doses of 100 mug and 200 mug has been compared with inhaled salbutamol, in a dose of 200 mug, and with placebo in patients with airways obstruction. 2 Both salmefamol and salbutamol are potent bronchodilators with a signficantly superior action over placebo at all times up to 8 h after treatmen... | Train | 3 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | [
1,
1,
1,
1,
0,
1,
0,
1
] | 406 |
27,210,618 | Salbutamol for transient tachypnea of the newborn. | Transient tachypnea of the newborn is characterized by tachypnea and signs of respiratory distress. Transient tachypnea typically appears within the first two hours of life in term and late preterm newborns. Although transient tachypnea of the newborn is usually a self limited condition, it is associated with wheezing ... | Train | 3 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | [
1,
1,
1,
0,
1,
1,
0,
1
] | 407 |
12,606,523 | Differential regulation of lipoprotein kinetics by atorvastatin and fenofibrate in subjects with the metabolic syndrome. | The metabolic syndrome is characterized by insulin resistance and abnormal apolipoprotein AI (apoAI) and apolipoprotein B-100 (apoB) metabolism that may collectively accelerate atherosclerosis. The effects of atorvastatin (40 mg/day) and micronised fenofibrate (200 mg/day) on the kinetics of apoAI and apoB were investi... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | [
1,
1,
1,
1,
1,
1,
1,
1
] | 408 |
29,476,697 | Salbutamol-induced Decrease in Augmentation Index is Related to the Parallel Increase in Heart Rate. | The change in augmentation index following salbutamol inhalation has been applied to evaluate endothelial function. We examined the contribution of salbutamol-induced increase in heart rate to the observed decrease in augmentation index. Haemodynamics were recorded using whole-body impedance cardiography and continuous... | Train | 3 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | [
1,
1,
0,
1,
1,
1,
1,
0
] | 410 |
14,962,237 | Treatment of primary orbital lymphomas. | We present an overview of the treatment and clinical outcome of 15 orbital lymphomas, carried out in our center from 1993 to 2002. The surgical approach was determined by the location, and type of the lesion. Lateral orbitotomy was performed in five laterally located lesions, a transconjunctival approach in five medial... | Train | 3 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | [
1,
1,
1,
1,
0,
0,
1,
0
] | 411 |
11,347,860 | Calcium antagonists and renal protection from cyclosporine nephrotoxicity: long-term trial in renal transplantation patients. | Cyclosporine (CsA) treatment in solid organ transplantation has represented one of the greatest advances in the past 20 years, reducing acute rejection and increasing long-term survival. However, CsA has an important side effect, producing renal vasoconstriction and systemic hypertension. The main histological findings... | Train | 3 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | [
1,
1,
1,
1,
0,
1,
0,
0
] | 413 |
19,933,994 | Effects of metformin with or without supplementation with folate on homocysteine levels and vascular endothelium of women with polycystic ovary syndrome. | To evaluate whether the administration of metformin exerts any effects on serum homocysteine (Hcy) levels in patients with polycystic ovary syndrome (PCOS) and whether supplementation with folate enhances the positive effects of metformin on the structure and function of the vascular endothelium. A total of 50 patients... | Train | 3 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | [
1,
1,
1,
1,
0,
1,
1,
1
] | 414 |
19,632,166 | Helicobacter pylori first-line treatment and rescue option containing levofloxacin in patients allergic to penicillin. | To assess the efficacy and tolerability of Helicobacter pylori first-line treatment (omeprazole-clarithromycin-metronidazole) and second-line rescue option (omeprazole-clarithromycin-levofloxacin) in patients allergic to penicillin. Prospective multicenter study including consecutive patients allergic to penicillin. T... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | [
1,
1,
1,
1,
1,
1,
1,
0
] | 415 |
24,090,628 | The association between tramadol hydrochloride misuse and other substances use in an adolescent population: Phase I of a prospective survey. | Tramadol hydrochloride is a common prescription pain reliever that is structurally similar to morphine and codeine with its analgesic effects identified as a mu-receptor agonist. Due to its opioid-like stimulant effects, the potential for tramadol misuse is a public health concern. As such, the aim of this investigatio... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | [
1,
1,
1,
1,
1,
1,
1,
0
] | 416 |
26,857,146 | The influence of prednisone on the efficacy of docetaxel in men with metastatic castration-resistant prostate cancer. | Prednisone and other corticosteroids can provide palliation and tumor responses in patients with prostate cancer. The combination of docetaxel and prednisone was the first treatment shown to prolong survival in men with metastatic castration-resistant prostate cancer (mCRPC). Since the approval of docetaxel in 2004, ad... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | [
1,
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1,
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1,
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] | 417 |
17,288,692 | A multi-centre, randomised, open-label study of atomoxetine compared with standard current therapy in UK children and adolescents with attention-deficit/hyperactivity disorder (ADHD). | To assess the broader efficacy (i.e., improvements in quality of life/functional outcomes) of atomoxetine compared with standard current therapy (SCT) in UK paediatric patients with ADHD and to explore clinician/parent/child perceptions of ADHD. A total of 201 patients with ADHD were randomised into this multi-centre, ... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | [
1,
1,
1,
1,
1,
1,
1,
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] | 418 |
15,860,022 | What is a clinically important level of improvement in symptoms of attention-deficit/hyperactivity disorder? | To compare the desired and actual reduction in scores on a parent reported behaviour rating scale in a naturalistic sample of children and adolescents who had been treated with psychostimulant medication, referenced to global ratings of treatment benefit. Forty-five parents reporting poor global response to psychostimu... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | [
1,
1,
1,
1,
1,
0,
1,
0
] | 419 |
29,721,712 | A retrospective analysis of medication prescription records for determining the levels of compliance and persistence to urate-lowering therapy for the treatment of gout and hyperuricemia in The Netherlands. | Urate-lowering therapy (ULT) is a recommended life-long treatment for gout patients. However, despite these recommendations, recurrent gout attacks are commonly observed in clinical practice. The purpose of this study was to assess the levels of compliance and persistence to ULT in The Netherlands, in order to reflect ... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | [
1,
1,
1,
1,
1,
1,
1,
0
] | 420 |
23,165,696 | Randomized, double-blind, placebo-controlled, phase II trial of gabapentin enacarbil for migraine prophylaxis. | The objective of this article is to evaluate the efficacy and safety of gabapentin enacarbil (GEn) for migraine prophylaxis. In this randomized, double-blind, parallel-group study, patients with International Headache Society-defined migraine who met criteria suggesting the need for prophylactic therapy were randomized... | Train | 3 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | [
1,
1,
1,
1,
0,
1,
1,
1
] | 421 |
16,213,265 | Simvastatin therapy in lymphocyte cross-match-positive kidney transplantation candidates. | Recent identification of several mechanisms by which statins decrease recruitment of monocytes and T cells into the arterial wall and inhibit both T-cell and B-cell activation and proliferation in vitro prompted us to study the immunomodulatory effects of statins. In this study, we examined the effect of simvastatin th... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | [
1,
1,
1,
1,
1,
1,
1,
0
] | 422 |
2,809,682 | Analysis of dose intensity in doxorubicin-containing adjuvant chemotherapy in stage II and III breast carcinoma. | Three hundred thirty-six patients with stage II or stage III breast cancer were treated on an adjuvant protocol containing fluorouracil, doxorubicin, cyclophosphamide, vincristine, and prednisone (FACVP). Depending on the estrogen-receptor (ER) status, the patients were subdivided to receive maintenance chemotherapy wi... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | [
1,
1,
1,
1,
1,
1,
1,
0
] | 423 |
22,265,151 | Use of topiramate and risk of glaucoma: a case-control study. | To examine the possible link of acute-onset glaucoma with topiramate. Case-control study. A case-control study was conducted among a cohort of subjects who had visited an ophthalmologist in the Province of British Columbia, Canada from 2000 to 2007. Cases were identified as those newly diagnosed with glaucoma (ICD-9 36... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | [
1,
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1,
1,
1,
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] | 425 |
7,628,284 | Role of omeprazole in prevention and treatment of postendoscopic variceal sclerotherapy esophageal complications. Double-blind randomized study. | Endoscopic variceal sclerotherapy-related esophageal complications are quite common. The potential efficacy of omeprazole in the prevention and treatment of postsclerotherapy esophageal complications was evaluated in 47 patients with portal hypertension in randomized, placebo-controlled study. Twenty-one patients in th... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | [
1,
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1,
1,
1,
1,
1,
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] | 426 |
20,339,536 | Genome-wide association of lipid-lowering response to statins in combined study populations. | Statins effectively lower total and plasma LDL-cholesterol, but the magnitude of decrease varies among individuals. To identify single nucleotide polymorphisms (SNPs) contributing to this variation, we performed a combined analysis of genome-wide association (GWA) results from three trials of statin efficacy. Bayesian ... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | [
1,
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] | 427 |
8,010,509 | [Insomnia and its treatment during the postoperative period]. | A total of 108 patients have filled in questionnaires on falling asleep, sleeping, night awakenings and other characteristics. Their answers have been analysed and it was concluded that night sleep of patients especially in the postoperative period was characterized by prolonged period of falling asleep (over 30 min in... | Train | 3 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | [
1,
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1,
0,
1,
1,
0
] | 428 |
10,821,991 | Carvedilol affects the physiological and behavioral response to smoked cocaine in humans. | The noradrenergic system is implicated in mediating some of the physiological effects of cocaine. The purpose of this study was to investigate whether treatment with an adrenergic blocker, carvedilol, which would be expected to attenuate the physiological effects of cocaine, would also attenuate the subjective and beha... | Train | 3 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | [
1,
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1,
0,
1,
1,
1
] | 430 |
10,636,577 | The place of diuretic enhanced Doppler sonography in distinguishing between obstructive and non-obstructive hydronephrosis in children. | In an attempt to differentiate obstructive from non-obstructive dilation of the renal collecting system in children, a prospective clinical study was carried out. During duplex Doppler sonography examination in 23 children resistive index (RI) and pulsatility index (PI) and RI ratio values before and after intraverous ... | Train | 3 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | [
1,
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0
] | 431 |
27,967,294 | Patterns of growth factor usage and febrile neutropenia among older patients with diffuse large B-cell non-Hodgkin lymphoma treated with CHOP or R-CHOP: the Intergroup experience (CALGB 9793; ECOG-SWOG 4494). | Patterns of myeloid growth factor (GF) usage and febrile neutropenia (FN) were examined in patients >60 years of age with diffuse large B-cell non-Hodgkin lymphoma (DLBCL) enrolled on CALGB 9793/ECOG-SWOG 4494, receiving initial therapy with cyclophosphamide, doxorubicin, vincristine, prednisone (CHOP) or rituximab + C... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | [
1,
1,
1,
1,
1,
1,
0,
0
] | 432 |
19,100,901 | Modern approaches to combining sirolimus with calcineurin inhibitors. | Routine renal transplantation maintenance immunosuppression at the University of Nebraska Medical Center consists of rabbit anti-thymocyte globulin (rATG) induction with early steroid withdrawal followed by maintenance with sirolimus and tacrolimus, a regimen we have used with >900 patients. Induction consists of 6 mg/... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | [
1,
1,
1,
1,
1,
1,
0,
0
] | 433 |
6,993,447 | Trazodone, a triazolopyridine derivative, in primary depressive disorder. | A double-blind controlled study was conducted to compare the effects of imipramine and placebo with trazodone, a new antidepressant, in 45 hospitalized patients with primary depression. After a three to seven-day baseline period, patients were treated for four weeks. Response was assessed by the Hamilton Psychiatric Sc... | Train | 3 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | [
1,
1,
1,
1,
0,
1,
1,
1
] | 434 |
17,499,602 | Effect of aspirin on long-term risk of colorectal cancer: consistent evidence from randomised and observational studies. | Randomised trials have shown that aspirin reduces the short-term risk of recurrent colorectal adenomas in patients with a history of adenomas or cancer, but large trials have shown no effect in primary prevention of colorectal cancer during 10 years' follow-up. However, the delay from the early development of adenoma t... | Train | 3 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | [
1,
1,
1,
0,
1,
1,
1,
1
] | 435 |
22,198,820 | Integrating interacting drugs and genetic variations to improve the predictability of warfarin maintenance dose in Chinese patients. | Compared with genetic factors, drug interactions are largely unexplored in pharmacogenetic studies. This study sought to systematically investigate the effects of VKORC1, STX4A, CYP2C9, CYP4F2, CYP3A4, and GGCX gene polymorphisms and interacting drugs on warfarin maintenance dose. A retrospective study of 845 Chinese p... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | [
1,
1,
1,
1,
1,
1,
1,
0
] | 437 |
12,912,816 | Comparative effects of carvedilol and metoprolol on regional vascular responses to adrenergic stimuli in normal subjects and patients with chronic heart failure. | Adrenergic receptor blockers used in the treatment of heart failure have distinct receptor affinity profiles. We hypothesized that alpha-adrenergic-blocking effects of carvedilol would limit vasoconstriction in response to adrenergic stimuli when compared with metoprolol. Forearm vascular resistance responses to isomet... | Train | 3 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 1 | [
1,
0,
1,
1,
1,
1,
0,
1
] | 438 |
20,135,063 | Clopidogrel non-responsiveness and risk of cardiovascular morbidity. An updated meta-analysis. | We performed this meta-analysis to update the clinical evidences on the relation between clopidogrel non-responsiveness and clinical outcomes in patients with coronary artery disease (CAD) who underwent percutaneous coronary intervention. An electronic literature search through MEDLINE, EMBASE, Web of Science, and the ... | Train | 3 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | [
1,
1,
1,
0,
1,
1,
1,
0
] | 441 |
9,539,597 | Inhaled prostaglandin E1 for treatment of acute lung injury in severe multiple organ failure. | Acute lung injury is characterized by hypoxemia due to pulmonary ventilation/perfusion-mismatching. I.v. administered prostaglandin E1 (PGE1), a vasodilator with a high pulmonary clearance, has been studied in acute lung injury. Inhalation of the vasodilators nitric oxide and prostacyclin improved oxygenation by select... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | [
1,
1,
1,
1,
1,
1,
1,
0
] | 442 |
10,506,395 | [Short- and long-term effects of intensified versus conventional antilipidemic therapy in patients with coronary heart disease. Results from the Lipid-Coronary Artery Disease (L-CAD) Study]. | In a prospective, randomized study of patients with acute manifestation of coronary heart disease and hypercholesterolemia (LDL cholesterol >/= 130 </= 250 mg/dl), we compared the effect of an early-initiated, intensified therapy to usual care antilipidemic therapy with respect to coronary lesions and clinical events. ... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | [
1,
1,
1,
1,
1,
1,
1,
1
] | 445 |
23,377,403 | Bone mineral density in patients with alopecia areata treated with long-term intralesional corticosteroids. | Intralesional corticosteroid injections are a common treatment for patchy alopecia areata, the most prevalent subtype of this autoimmune hair disorder. To date, no studies have examined the potential adverse effects of this therapy on bone mineral density (BMD). In this retrospective, cross-sectional case series, 18 pa... | Train | 3 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | [
1,
1,
1,
1,
0,
1,
1,
0
] | 446 |
7,138,751 | Comparison of two long-acting preparations of metoprolol with conventional metoprolol and atenolol in healthy men during chronic dosing. | 1 Eight healthy men received two long-acting formulations of metoprolol 200 mg (SA Astra, SR Geigy), conventional metoprolol 200 mg and atenolol 100 mg once daily for 1 week each in balanced, crossover fashion. There was a washout period of at least a week between each phase. 2 On the last day of each phase, post-exerc... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | [
1,
1,
1,
1,
1,
1,
1,
1
] | 447 |
26,635,328 | Comparison of antidepressant classes and the risk and time course of suicide attempts in adults: propensity matched, retrospective cohort study. | Placebo-controlled clinical trials have led to concern over possible increased risk of suicide-related events in some populations exposed to antidepressants. To evaluate the risk of suicide attempts by antidepressant drug class and the presence or absence of depression. A retrospective propensity-matched new-user cohor... | Train | 3 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | [
1,
1,
1,
1,
0,
1,
0,
1
] | 449 |
8,789,310 | Quadruple therapy compared with dual therapy for eradication of Helicobacter pylori in ulcer patients: results of a randomized prospective single-centre study. | To assess the efficacy and side-effect profile of two currently advocated treatment regimens for eradicating Helicobacter pylori. A randomized, controlled, open, single-centre study. A community hospital in The Netherlands. Seventy-six consecutive patients with (chronic) ulcer disease and biopsy-proven H. pylori infect... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | [
1,
1,
1,
1,
1,
1,
1,
1
] | 450 |
24,357,838 | Spontaneous superior ophthalmic vein thrombosis: a rare entity with potentially devastating consequences. | Spontaneous superior ophthalmic vein thrombosis (SOVT) is a rare entity. We describe three patients with spontaneous ophthalmic vein thrombosis, each with various risk factors. A retrospective review of three patients with a diagnosis of superior ophthalmic vein thrombosis. Clinical characteristics, radiographic featur... | Train | 3 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | [
1,
1,
1,
1,
0,
0,
1,
0
] | 451 |
1,593,361 | Loracarbef (LY163892) versus amoxicillin-clavulanate in the treatment of bacterial acute otitis media with effusion. | The efficacy and safety of loracarbef, a new beta-lactam antibiotic, was compared with that of amoxicillin-clavulanate potassium in the treatment of bacterial acute otitis media with effusion. A double-blind format was utilized to administer 10-day, randomized, parallel treatment regimens to patients who were between 6... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | [
1,
1,
1,
1,
1,
1,
0,
0
] | 453 |
22,267,183 | Brain activity in adolescent major depressive disorder before and after fluoxetine treatment. | Major depression in adolescents is a significant public health concern because of its frequency and severity. To examine the neurobiological basis of depression in this population, the authors studied functional activation characteristics of the brain before and after antidepressant treatment in antidepressant-naive de... | Train | 3 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | [
1,
1,
1,
1,
0,
1,
1,
1
] | 454 |
34,114,659 | Non-steroidal anti-inflammatory drugs, polygenic risk score and colorectal cancer risk. | The regular use of non-steroidal anti-inflammatory drugs (NSAIDs) has been associated with reduced colorectal cancer (CRC) risk. To explore whether this association varies according to background polygenic risk for CRC. Data were collected from a large population-based case-control study on CRC in Germany. A polygenic ... | Train | 3 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | [
1,
1,
1,
0,
1,
1,
1,
1
] | 456 |
18,430,300 | Failure of amoxicillin to produce false-positive urine screens for cocaine metabolite. | Amoxicillin has been causally linked in the lay and medical literature to false-positive urine drug screens for cocaine metabolites. An exhaustive search of the peer-reviewed medical literature revealed no data to support this link. We hypothesized that amoxicillin does not cause false-positive urine drug screens for c... | Train | 3 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | [
1,
1,
0,
1,
0,
1,
1,
0
] | 457 |
24,947,719 | Prasugrel versus clopidogrel in patients with ST-segment elevation myocardial infarction according to timing of percutaneous coronary intervention: a TRITON-TIMI 38 subgroup analysis (Trial to Assess Improvement in Therapeutic Outcomes by Optimizing Platelet Inhibition with Prasugrel-Thrombolysis In Myocardial Infarcti... | This study sought to evaluate the efficacy of prasugrel versus clopidogrel in ST-segment elevation myocardial infarction (STEMI) by the timing of percutaneous coronary intervention (PCI). Treatment strategies and outcomes for patients with STEMI may differ when treated with primary compared with secondary PCI. STEMI pa... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | [
1,
1,
1,
1,
1,
1,
0,
1
] | 458 |
2,198,308 | Social judgment processes in hyperactive boys: effects of methylphenidate and comparisons with normal peers. | Although there is consensus that ADHD children have serious social problems, there is little understanding of the mechanisms underlying or accompanying such problems. To examine the possibility of atypical or faulty social reasoning, we presented ADHD and normal boys with a social perception task that entailed evaluati... | Train | 3 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | [
1,
1,
1,
1,
0,
1,
0,
1
] | 459 |
24,776,622 | Efficacy and safety of combined parenteral and oral steroid therapy in Graves' orbitopathy. | Glucocorticoids (GC) are the treatment of choice for moderate-to-severe and active Graves' orbitopathy (GO), but optimal treatment is still . The aim of the present study was to analyze the efficacy and tolerability of combined parenteral GC pulse therapy followed by oral GC in the interpulse period. The study included... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | [
1,
1,
1,
1,
1,
1,
1,
0
] | 460 |
11,110,349 | Treating hyperlipidemia in African Americans. | The purpose of this paper is to provide information concerning the treatment of hyperlipidemia in African Americans. There is a similar prevalence of hypercholesterolemia in Blacks and Whites, but Blacks have been neglected in most pharmacological studies of hyperlipidemia. Intimal atherosclerotic involvement of the ao... | Train | 3 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | [
1,
1,
1,
0,
0,
1,
0,
0
] | 463 |
26,056,020 | Bone mineral density and bone microarchitecture after long-term suppressive levothyroxine treatment of differentiated thyroid carcinoma in young adult patients. | Bone mineral density (BMD) seems not to be decreased in young patients given long-term suppressive doses of levothyroxine (LT4), but information regarding the bone microstructure in these patients is lacking. The aim of this study was to determine whether supraphysiologic doses of LT4, initiated during childhood or ado... | Train | 3 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | [
1,
1,
1,
1,
0,
1,
1,
1
] | 464 |
2,196,623 | Fluoxetine: relationships among dose, response, adverse events, and plasma concentrations in the treatment of depression. | Data from two large, fixed-dose trials support the efficacy of a fixed 20 mg/day dose of fluoxetine in the treatment of depression. Data pooled from these two studies suggest a dose relationship for adverse events during fluoxetine therapy. At a fixed 20 mg/day dose, only nausea and insomnia were reported by a signific... | Train | 3 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 1 | [
1,
0,
1,
0,
1,
1,
0,
1
] | 465 |
33,713,192 | Adverse reactions to subcutaneous immunotherapy in patients with allergic rhinitis, a real-world study. | The efficacy of subcutaneous immunotherapy (SCIT) for allergic rhinitis (AR) have been proven but application is still limited by concerns about the safety. The aims of this study were to investigate the incidence of adverse reactions and to ascertain possible risk factors in patients treated with SCIT in central China... | Train | 3 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | [
1,
1,
1,
1,
0,
1,
1,
0
] | 466 |
11,836,798 | Salbutamol dry powder inhaler: efficacy, tolerability, and acceptability study. | Dry powder inhaler (DPI) devices are frequently used in children over 5 years of age in order to avoid coordination difficulties often seen with the use of pressurized metered dose inhalers (pMDI). This study assessed the efficacy, tolerability, and acceptability of salbutamol delivered via two delivery systems, in a p... | Train | 3 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | [
1,
1,
0,
1,
1,
1,
1,
1
] | 468 |
24,434,886 | Zolpidem and restoration of consciousness. | Zolpidem has been reported to cause temporary recovery of consciousness in vegetative and minimally conscious patients, but how often and why this occurs are unknown. The authors aimed to determine the frequency of this phenomenon and whether it can be predicted from demographic and clinical variables. This is a placeb... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | [
1,
1,
1,
1,
1,
1,
1,
1
] | 469 |
7,040,497 | The effects of a single, intravenous dose of bumetanide versus furosemide in patients with ascites and edema due to alcoholic liver disease. | Ascites with or without edema, secondary to alcoholic liver disease, which had failed to respond to conventional in-hospital medical treatment with thiazides, spironolactone, and salt restriction was treated with a single intravenous dose of 0.5 mg bumetanide or 20 mg furosemide. In this single-blind, randomized, paral... | Train | 3 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | [
1,
1,
1,
1,
0,
1,
1,
0
] | 471 |
8,517,172 | Mortality in major affective disorder: relationship to subtype of depression. The Danish University Antidepressant Group. | A total of 219 inpatients with a DSM-III diagnosis of major depression, 150 women and 69 men, were followed prospectively for 3-10 years and mortality was recorded. The patients were previous participants in psychopharmacological multicenter trials, which were carried out for the purpose of comparing the antidepressant... | Train | 3 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | [
1,
1,
1,
1,
0,
1,
1,
0
] | 472 |
30,383,607 | Efficacy and Safety of Loading Doses With P2Y12-Receptor Antagonists in Patients Without Dual Antiplatelet Therapy Undergoing Elective Coronary Intervention. | European Guidelines on Myocardial Revascularization recommend clopidogrel loading dose added to acetylsalicylic acid in elective percutaneous coronary interventions (PCIs). However, there is few evidence supporting this recommendation and other P2Y12 inhibitors have not been tested in these patients. To evaluate the ef... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | [
1,
1,
1,
1,
1,
1,
1,
0
] | 473 |
2,551,805 | [Modification of blood coagulation by antihypertensive therapy? Effect of enalapril and hydrochlorothiazide on blood coagulation parameters in patients with essential hypertension]. | An increased tendency of the blood to clot in patients with arterial hypertension is not desirable, since cardiovascular and cerebrovascular sequelae may be aggravated. Recently, activation of coagulation under ACE inhibition with captopril has been described. In an open, randomized study, we compared the influence of ... | Train | 3 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | [
1,
1,
1,
1,
0,
1,
0,
0
] | 474 |
23,594,617 | Ticagrelor improves peripheral arterial function in patients with a previous acute coronary syndrome. | The novel P2Y12 antagonist ticagrelor inhibits adenosine diphosphate (ADP)-induced platelet aggregation more potently than clopidogrel and reduces the incidence of myocardial infarction and total death in patients with an acute coronary syndrome (ACS). Furthermore, ticagrelor inhibits adenosine reuptake and increases c... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | [
1,
1,
1,
1,
1,
1,
1,
1
] | 475 |
15,326,072 | Regression of hypertensive left ventricular hypertrophy by losartan compared with atenolol: the Losartan Intervention for Endpoint Reduction in Hypertension (LIFE) trial. | An echocardiographic substudy of the Losartan Intervention for Endpoint Reduction in Hypertension (LIFE) trial was designed to test the ability of losartan to reduce left ventricular (LV) mass more than atenolol. A total of 960 patients with essential hypertension and LV hypertrophy (LVH) on screening ECG were enrolled... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | [
1,
1,
1,
1,
1,
1,
1,
0
] | 477 |
12,538,743 | Enalapril and losartan reduce sympathetic hyperactivity in patients with chronic renal failure. | The aim of this study was to compare the effects on BP and sympathetic activity of chronic treatment with an angiotensin (Ang)-converting enzyme (ACE) inhibitor and an AngII receptor blocker in hypertensive patients with chronic renal failure (CRF). In ten stable hypertensive CRF patients (creatinine clearance, 46 +/- ... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | [
1,
1,
1,
1,
1,
1,
1,
0
] | 478 |
18,794,724 | Plasminogen activator inhibitor-1 gene is associated with major depression and antidepressant treatment response. | Evidence suggests that plasminogen activator inhibitor type 1 gene (SERPINE1) is a stress-related gene and serum plasminogen activator inhibitor type 1 levels are increased in patients with major depressive disorders (MDD). To investigate whether common genetic variation in the SERPINE1 gene is associated with MDD and ... | Train | 3 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | [
1,
1,
1,
0,
1,
0,
1,
1
] | 479 |
23,787,795 | Age and sex inequalities in the prescription of evidence-based pharmacological therapy following an acute coronary syndrome in Portugal: the EURHOBOP study. | To assess the proportion of patients receiving pharmacological therapy for secondary prevention after an acute coronary syndrome (ACS) in Portugal and to identify age and sex inequalities. Retrospective cohort study. We studied 747 episodes of ST-segment elevation myocardial infarction (STEMI) and 1364 of non-ST-segmen... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | [
1,
1,
1,
1,
1,
1,
1,
0
] | 480 |
24,936,092 | Risk and benefit of dual antiplatelet treatment among non-revascularized myocardial infarction patients in different age groups. | Dual anti-platelet treatment with clopidogrel and aspirin is indicated for most patients after myocardial infarction. We examined the risk/benefit relationship of dual anti-platelet treatment according to age in a nationwide cohort of 30,532 myocardial infarction patients without revascularization. Patients admitted wi... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | [
1,
1,
1,
1,
1,
1,
1,
1
] | 483 |
16,225,499 | Helicobacter pylori eradication in childhood after failure of initial treatment: advantage of quadruple therapy with nifuratel to furazolidone. | Failures of Helicobacter pylori eradication in children are common. To evaluate the efficacy of amoxicillin, bismuth subcitrate and omeprazole and nifuratel or furazolidone for H. pylori eradication in children who failed initial treatment with a standard triple therapy. Seventy-six consecutive H. pylori-positive paedi... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | [
1,
1,
1,
1,
1,
1,
1,
0
] | 484 |
30,389,130 | Intraoperative prediction of cardiac surgery-associated acute kidney injury using urinary biomarkers of cell cycle arrest. | Tissue inhibitor of metalloproteinases 2 (TIMP-2) and insulin-like growth factor-binding protein 7 (IGFBP7) are postoperative urinary biomarkers of renal stress and acute kidney injury (AKI). We conducted this study to test the hypothesis that intraoperative concentrations of urinary [TIMP-2]·[IGFBP7] are associated wi... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | [
1,
1,
1,
1,
1,
1,
1,
1
] | 485 |
26,857,424 | Evaluation of Quality of Life, Functioning, Disability, and Work/School Productivity Following Treatment with an Extended-Release Hydrocodone Tablet Formulated with Abuse-Deterrence Technology: A 12-month Open-label Study in Patients with Chronic Pain. | This phase 3 study evaluated quality of life, functioning, and productivity after treatment with extended-release (ER) hydrocodone formulated with CIMA<sup>®</sup> Abuse-Deterrence Technology platform. Patients with chronic pain were rolled over from a 12-week placebo-controlled hydrocodone ER study or were newly enrol... | Train | 3 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | [
1,
1,
1,
1,
0,
1,
1,
1
] | 487 |
19,195,912 | Gabapentin therapy improves heart rate variability in diabetic patients with peripheral neuropathy. | Diabetic cardiac neuropathy, which is characterized by reduced heart rate variability (HRV), frequently coexists with peripheral neuropathy. Gabapentin has been used for the treatment of diabetic neuropathy. We aimed to evaluate the possible effect of gabapentin treatment on autonomic function in patients with type 2 d... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | [
1,
1,
1,
1,
1,
1,
1,
1
] | 489 |
11,806,983 | Double-delayed intensification improves event-free survival for children with intermediate-risk acute lymphoblastic leukemia: a report from the Children's Cancer Group. | Addition of a delayed-intensification (DI) phase after standard induction/consolidation therapy was previously shown to improve outcome for patients younger than 10 years of age with intermediate-risk acute lymphoblastic leukemia (ALL). The current trial randomized 1204 patients to regimens containing a single DI phase... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | [
1,
1,
1,
1,
1,
0,
1,
1
] | 490 |
1,994,532 | Multivariate analysis of donor-specific versus random transfusion protocols in haploidentical living-related transplants. | A total of 127 haploidentical living-related transplants have been performed at our institution since March 1986. A donor-specific transfusion plus azathioprine protocol was used until July 1988 (n = 74) and a random transfusion (RT) protocol without AZA used thereafter (n = 53) in an effort to decrease risk of recipie... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | [
1,
1,
1,
1,
1,
1,
1,
1
] | 491 |
11,446,835 | The choice of timing for diuresis renography: the F + 0 method. | To investigate a method of diuresis renography where the radiopharmaceutical and frusemide (diuretic) are given simultaneously, in contrast to conventional renography which involves an intravenous injection with frusemide 20 min after administering the radiopharmaceutical (F + 20) or 15 min before (F - 15), with partic... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | [
1,
1,
1,
1,
1,
1,
1,
0
] | 492 |
15,932,725 | [Necessity and safety of conversion from mycophenolate mofetil to AzA thioprine after renal transplantation]. | To investigate the necessity and safety of conversion from mycophenolate mofetil (MMF) to Azathioprine (AzA) in stable renal transplant patients. In a randomised open clinical trial, A total of 87 low-risk renal allograft recipients on triple immunosuppressive therapy (prednisone/MMF/cyclosporine) 6 months after transp... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | [
1,
1,
1,
1,
1,
1,
1,
1
] | 493 |
9,284,849 | Pharmacokinetics and pharmacodynamics of single oral doses of albuterol and its enantiomers in humans. | Albuterol (INN, salbutamol) is a beta 2-adrenergic receptor agonist widely used in the treatment of asthma. It is administered clinically as a racemic mixture, but only one enantiomer is active (eutomer) while the other (distomer) has been implicated in causing toxicity. This study used a chiral assay to compare the ph... | Train | 3 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | [
1,
1,
1,
1,
0,
1,
1,
0
] | 496 |
11,809,183 | Intravenous immunoglobulin or high-dose methylprednisolone, with or without oral prednisone, for adults with untreated severe autoimmune thrombocytopenic purpura: a randomised, multicentre trial. | Treatment of adults with autoimmune thrombocytopenic purpura (AITP) is based more on individual experience than on results of controlled studies. We compared intravenous immunoglobulin with high-dose methylprednisolone in untreated adults with severe AITP and assessed efficacy of subsequent oral steroids compared with ... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | [
1,
1,
1,
1,
1,
1,
1,
1
] | 497 |
33,162,063 | Risk of postprocedural intracerebral hemorrhage in patients with ruptured cerebral aneurysms after treatment with antiplatelet agents. | Endovascular treatment of ruptured cerebral aneurysms frequently requires antiplatelet medication to prevent thromboembolism. This might raise concern regarding the risk of postprocedural hemorrhage (pH), e.g. from placement of intracranial probes. We explored the risk of PH associated with standard antiplatelet therap... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | [
1,
1,
1,
1,
1,
1,
1,
0
] | 498 |
17,324,745 | Predictors of antihypertensive drug responses: initial data from a placebo-controlled, randomized, cross-over study with four antihypertensive drugs (The GENRES Study). | Only a minority of hypertensive individuals is adequately controlled for their hypertension, partially because reliable predictors for efficient antihypertensive drug therapy are lacking. In a prospective, randomized, double-blind, cross-over, placebo-controlled study (The GENRES Study), 208 moderately hypertensive Fin... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | [
1,
1,
1,
1,
1,
1,
1,
1
] | 499 |
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