PMID int64 2.09k 36.2M | Title stringlengths 21 414 | Abstract stringlengths 175 8.83k | Split stringclasses 1
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7,484,829 | Design, rational, and baseline characteristics of the Prospective Pravastatin Pooling (PPP) project--a combined analysis of three large-scale randomized trials: Long-term Intervention with Pravastatin in Ischemic Disease (LIPID), Cholesterol and Recurrent Events (CARE), and West of Scotland Coronary Prevention Study (W... | The Prospective Pravastatin Pooling (PPP) project is a pooled evaluation of 3 large, placebo-controlled, randomized trials of cholesterol-lowering treatment with pravastatin. It is designed to more reliably evaluate the effect of treatment on coronary and all-cause mortality and on total coronary artery disease (CAD) e... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | [
1,
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1,
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1,
1,
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] | 500 |
24,009,042 | Enhanced active metabolite generation and platelet inhibition with prasugrel compared to clopidogrel regardless of genotype in thienopyridine metabolic pathways. | Clopidogrel response varies according to the presence of genetic polymorphisms. The CYP2C19*2 allele has been associated with impaired response; conflicting results have been reported for CYP2C19*17, ABCB1, and PON1 genotypes. We assessed the impact of CYP2C19, PON1, and ABCB1 polymorphisms on clopidogrel and prasugrel... | Train | 3 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | [
1,
1,
1,
1,
0,
1,
1,
1
] | 502 |
7,852,749 | Within-patient correlation between the antihypertensive effects of atenolol, lisinopril and nifedipine. | To investigate whether there are definable subgroups of patients with essential hypertension who respond specifically to particular antihypertensive drugs. Randomized cross-over comparison of the antihypertensive effect of 50 mg atenolol per day, 10 mg lisinopril per day and 20 mg nifedipine retard twice a day. Ambulat... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | [
1,
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1,
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1,
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] | 503 |
15,070,633 | Three day versus five day treatment with amoxicillin for non-severe pneumonia in young children: a multicentre randomised controlled trial. | To assess the efficacy of three days versus five days of treatment with oral amoxicillin for curing non-severe pneumonia in children. Randomised, double blind, placebo controlled multicentre trial. Outpatient departments of seven referral hospitals in India. 2188 children aged 2-59 months, 1095 given three days of trea... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | [
1,
1,
1,
1,
1,
1,
1,
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] | 504 |
35,034,692 | Management of American Heart Association/American College of Cardiology-Defined Stage 2 Hypertension by Cardiologists in India. | Uncontrolled hypertension is an important cardiovascular risk factor and therefore requires effective approaches to patient management. This study assessed approaches to the management of patients with Stage 2 hypertension by cardiologists in India. This was a retrospective, multicenter, observational, case-based quest... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | [
1,
1,
1,
1,
1,
0,
1,
0
] | 505 |
26,520,013 | Impact of Carvedilol versus β1-selective β blockers (bisoprolol, metoprolol, and nebivolol) in patients with acute myocardial infarction undergoing percutaneous coronary intervention. | Although β blocker (BB) has constituted one of the mainstays of evidence-based therapy for patients with acute myocardial infarction (AMI), the comparative efficacy of different BBs remains uncertain. We sought to determine the comparative effectiveness of nonselective BB carvedilol and the most frequently prescribed β... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | [
1,
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1,
1,
1,
1,
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] | 506 |
34,174,365 | Combination of Rituximab, Low-Dose Cyclophosphamide, and Prednisone for Primary Membranous Nephropathy: A Case Series With Extended Follow Up. | B-cell depletion with rituximab has emerged as a first-line therapy for primary membranous nephropathy (MN). However, most patients do not achieve complete remission with rituximab monotherapy. In this case series, we report longer-term remission and relapse rates, anti-phospholipase A<sub>2</sub> receptor (PLA<sub>2</... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | [
1,
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1,
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1,
1,
0
] | 509 |
9,110,907 | A trial of three regimens for primary amyloidosis: colchicine alone, melphalan and prednisone, and melphalan, prednisone, and colchicine. | Primary systemic amyloidosis is an uncommon disease characterized by the accumulation in vital organs of a fibrillar protein consisting of monoclonal light chains. We treated 220 patients with biopsy-proved amyloidosis. The patients were randomly assigned to receive colchicine (72 patients), melphalan and prednisone (7... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | [
1,
1,
1,
1,
1,
1,
1,
0
] | 510 |
7,543,069 | Granulocyte colony-stimulating factor (G-CSF) prevents dose-limiting neutropenia in lymphoma patients receiving standard dose chemotherapy. | In this study, nine patients with non-Hodgkin's lymphoma (n = 6) and Hodgkin's disease (n = 3) receiving different cytotoxic chemotherapy regimens were given granulocyte colony-stimulating factor (G-CSF) (5 micrograms/kg/day) from 48 hours after the end of chemotherapy to 48 hours before the next chemotherapy administr... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | [
1,
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1,
1,
0
] | 511 |
1,883,123 | Influence of gastric acidity on the bioavailability of digoxin. | To study how changes in gastric acidity induced by omeprazole and pentagastrin affect the absorption of unchanged digoxin and its hydrolytic breakdown products. Double-blind, double-dummy, randomized, crossover study. Academic department of clinical pharmacology. Six healthy male volunteers. Subjects received digoxin, ... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | [
1,
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1,
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1,
1,
1
] | 512 |
9,711,053 | [Bioequivalence of a combination of levothyroxine and iodine in comparison with levothyroxine only. A controlled double-blind study of bioavailability]. | Iodine deficiency is the main cause of endemic goitre. Iodine supplementation and decrease of pituitary TSH are the therapeutical aims. In this study, bioavailability of levothyroxine combined with iodide and the same dose of levothyroxine alone were compared. Fourty-eight subjects aged 18 to 40 years were randomly ass... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | [
1,
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1,
1,
1,
1,
1,
1
] | 514 |
27,941,393 | Use of rosuvastatin in HIV-associated chronic obstructive pulmonary disease. | Chronic obstructive pulmonary disease (COPD) is more prevalent in HIV-infected individuals and is associated with persistent inflammation. Therapies unique to HIV are lacking. We performed a pilot study of the 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor rosuvastatin to determine effects on lung function. ... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | [
1,
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1,
1,
1,
1
] | 515 |
18,788,689 | Effect of atorvastatin on LDL & hs-CRP in a selected Thai population. | LDL and hs-CRP are risk factors for vascular events and can be modified by Statin. To evaluate the baseline hs-CRP of a certain Thai population who would need Atorvastatin, to evaluate the dose response of Atorvastatin toward LDL and hs-CRP level, and to evaluate the efficacy and safety of different types of Atorvastat... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | [
1,
1,
1,
1,
1,
1,
1,
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] | 516 |
14,563,238 | [Lung aspergillosis. Role of the corticoids as associated risk factor in the patient with chronic bronchitis]. | Description of a situation of incidence increase of bronchial secretions with positive cultures for Aspergillus fumigatus, and analysis of the related risk factors in the invasive aspergillosis. Between January 1999 and February 2000, a prospective study of the patients was conducted with culture of bronchial secretion... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | [
1,
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1,
1,
1,
1,
0
] | 517 |
29,128,692 | COAST (Cisplatin ototoxicity attenuated by aspirin trial): A phase II double-blind, randomised controlled trial to establish if aspirin reduces cisplatin induced hearing-loss. | Cisplatin is one of the most ototoxic chemotherapy drugs, resulting in a permanent and irreversible hearing loss in up to 50% of patients. Cisplatin and gentamicin are thought to damage hearing through a common mechanism, involving reactive oxygen species in the inner ear. Aspirin has been shown to minimise gentamicin-... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | [
1,
1,
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1,
1,
1,
1,
1
] | 519 |
16,737,147 | [Simvor in the treatment of hyperlipoproteinaemia]. | Treatment of hyperlipoproteinaemias (HLP) is a basic step in prevention and treatment of atherosclerosis and its complications. Simvastatin is among hypolipidaemic agents a preparation for which at present there is most evidence from intervention trials. On the Czech market are at present in addition to the original on... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | [
1,
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1,
1,
1,
1,
0
] | 520 |
12,511,152 | Trials and tribulations: current challenges in conducting clinical trials. | Randomized controlled trials are the gold standard for the evaluation of new therapies and surgical procedures and as such require strict attention to study design and statistical analysis. There are, however, multiple challenges in conducting a well-designed clinical trial. This article describes the difficulties enco... | Train | 3 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | [
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] | 521 |
17,516,127 | Maternal and fetal outcomes of 72 pregnancies in Argentine patients with systemic lupus erythematosus (SLE). | The purpose of the following study was to analyze maternal and fetal outcomes in pregnant patients with systemic lupus erythematosus (SLE) and the influence of SLE exacerbations on those pregnancies. Seventy-two pregnancies in 61 SLE patients treated between January 1986 and February 2004 in Hospital de Clínicas "José ... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | [
1,
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1,
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0,
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] | 522 |
10,806,662 | [Role of hyperinsulinemia in pathogenesis of polycystic ovary syndrome and treatment by reduction of insulin secretion]. | To investigate the role of insulin in the polycystic ovary syndrome (PCOS) pathogenesis and application of Metformin in the treatment of PCOS. Serum androgen, luteinizing hormone (LH) and sex hormone-binding globulin(SHBG) concentration during fasting and serum 17 alpha-hydroxyprogesterone (17-OHP), LH level in respons... | Train | 3 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | [
1,
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1,
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1,
1,
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] | 523 |
3,888,969 | The effects and effectiveness of gamma-hydroxybutyrate in patients with narcolepsy. | Thirty patients with polysomnographically confirmed narcolepsy were treated with GHB (gamma-hydroxybutyrate) for up to 30 weeks. The number of nightly awakenings significantly decreased, while Stages 3 and 4 sleep substantially increased. The clinical symptoms of cataplexy, sleep paralysis, hypnogogic hallucinations, d... | Train | 3 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | [
1,
1,
1,
1,
0,
1,
1,
0
] | 524 |
7,662,221 | Comparison of the hemodynamic and metabolic effects of low-dose hydrochlorothiazide and lisinopril treatment in obese patients with high blood pressure. | Patients with high blood pressure tend to be insulin resistant, glucose intolerant, hyperinsulinemic, and dyslipidemic. Since these metabolic defects are accentuated by obesity, we thought it important to compare the effects of 3 months' treatment with either lisinopril (20 mg/day) or low dose hydrochlorothiazide (12.5... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | [
1,
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] | 525 |
15,262,833 | Effect of atorvastatin on risk of recurrent cardiovascular events after an acute coronary syndrome associated with high soluble CD40 ligand in the Myocardial Ischemia Reduction with Aggressive Cholesterol Lowering (MIRACL) Study. | Patients with acute coronary syndromes have elevated plasma levels of the proinflammatory, prothrombotic cytokine CD40 ligand (sCD40L). Statins inhibit CD40L signaling in vitro, but there are no prospective studies of statins and sCD40L in acute coronary syndromes. We measured sCD40L in subjects with an acute coronary ... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | [
1,
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] | 526 |
15,921,795 | A direct comparison of the natriuretic peptides and their relationship to survival in chronic heart failure of a presumed non-ischaemic origin. | The natriuretic peptides have been validated as sensitive and specific markers of left ventricular dysfunction; brain natriuretic peptide (BNP), N-terminal atrial natriuretic peptide (NT-proANP) and N-terminal brain natriuretic peptide (NT-proBNP) elevations have been associated with New York Heart Association (NYHA) C... | Train | 3 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | [
1,
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1,
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1,
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] | 527 |
18,401,285 | Combination therapy (intratympanic dexamethasone + high-dose prednisone taper) for the treatment of idiopathic sudden sensorineural hearing loss. | Idiopathic Sudden Sensorineural Hearing Loss (ISSNHL), commonly defined as greater than 20 dB of unilateral hearing loss in at least 3 frequencies occurring within 3 days, has a reported incidence of 5 to 20 per 100,000 patients per year. Untreated, it has a recovery rate of 32 to 65%. Although accepted therapy is high... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | [
1,
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] | 531 |
7,960,688 | A multicenter, double-blind, randomized controlled study of omeprazole versus ranitidine in the treatment of duodenal ulcer in Israel. | A multicenter, double-blind, randomized, controlled study of 203 Israeli patients with endoscopically proven duodenal ulcer is described. The study compares the efficacy (i.e., ulcer healing and relief of symptoms) and safety of 20 mg omeprazole once daily in the morning, with those of 300 mg ranitidine once daily at n... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | [
1,
1,
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1,
1,
1,
1,
0
] | 532 |
9,324,011 | Rheumatoid arthritis and the risk of malignancy. | To determine the relative risks of malignancy and of site-specific malignancies in patients with rheumatoid arthritis (RA). In a prospective cohort study, 862 patients with RA (96% white) were enrolled from 1966 to 1974 and were followed up for up to 35 years (mean 17.4 years) at the University of Saskatchewan Rheumati... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | [
1,
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1,
1,
1,
1,
0
] | 533 |
12,150,648 | Psychosocial outcomes following long-term, double-blind treatment of chronic depression with sertraline vs placebo. | Chronic forms of depression are associated with significant functional and psychosocial impairments. To date, no study has measured psychosocial functioning in this population during long-term maintenance antidepressant treatment or following the double-blind discontinuation of treatment. Patients with chronic major or... | Train | 3 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | [
1,
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1,
0,
1,
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] | 534 |
26,067,725 | Odontogenic Infections: A 1-year Retrospective Study. | The purpose of this study was to analyze the prevalence, demographic patterns and management of odontogenic infections in patients undergoing treatment in an outpatient dental emergency service of a university hospital. In a retrospective study of the year 2012, all patients suffering from odontogenic infections were i... | Train | 3 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | [
1,
1,
1,
0,
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1,
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] | 535 |
7,726,309 | Gender differences in onset of illness, treatment response, course, and biologic indexes in first-episode schizophrenic patients. | Gender differences in onset of illness, response to treatment, course, and biologic measures have been consistently reported in patients with chronic schizophrenia. Patients with first-episode schizophrenia were examined to determine whether gender differences also occur in these patients. Fifty-four neuroleptic-naive ... | Train | 3 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | [
1,
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1,
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] | 536 |
15,034,285 | [Therapeutic effect of low-dose omeprazole vs. standard-dose ranitidine in mild to moderate reflux esophagitis]. | Proton pump inhibitors (PPI) and H2-receptor antagonists (H2RA) are commonly prescribed for the treatment of mild to moderate reflux esophagitis (MMRE). There remains great controversy in their usefulness as the first choice and the appropriateness. We prospectively compared the efficacy and safety of the 8-week low-do... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | [
1,
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1,
1,
1,
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] | 537 |
29,620,701 | Pharmacokinetics of Sustained-Release Oral Dexamphetamine Sulfate in Cocaine and Heroin-Dependent Patients. | Research has shown that sustained-release (SR) dexamphetamine is a promising agonist treatment for cocaine dependence. However, little is known about the pharmacokinetics (PKs) of SR oral dexamphetamine. This study examined the PKs of a new SR dexamphetamine formulation in cocaine plus heroin-dependent patients current... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | [
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] | 538 |
8,349,327 | Salt-dependent renal effects of an angiotensin II antagonist in healthy subjects. | This study was designed to evaluate in healthy volunteers the renal hemodynamic and tubular effects of the orally active angiotensin II receptor antagonist losartan (DuP 753 or MK 954). Losartan or a placebo was administered to 23 subjects maintained on a high-sodium (200 mmol/d) or a low-sodium (50 mmol/d) diet in a r... | Train | 3 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | [
1,
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1,
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] | 539 |
20,836,617 | Investigational agents for the irritable bowel syndrome. | Irritable bowel syndrome (IBS) is a common disorder with significant health and economic consequences. The etiology of IBS is complex and appears to be multifactorial. Traditional IBS therapies have been directed primarily at the relief of individual symptoms but have been largely disappointing. This has triggered the ... | Train | 3 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | [
1,
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1,
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0,
0,
0,
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] | 540 |
29,913,261 | Hydrochlorothiazide use and risk for Merkel cell carcinoma and malignant adnexal skin tumors: A nationwide case-control study. | Hydrochlorothiazide use has been associated with markedly increased risk for squamous cell carcinoma. No previous studies have investigated the association between hydrochlorothiazide use and the risk for Merkel cell carcinoma (MCC) and malignant adnexal skin tumors (MAST). To examine the association between hydrochlor... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | [
1,
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1,
1,
1,
0,
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] | 541 |
33,528,116 | Intraperitoneal administration of lidocaine or tramadol alone or in combination on postoperative pain after ovariohysterectomy in dogs. | The present prospective randomized experimental study aimed to assess the intraperitoneal (ip) administration of lidocaine or tramadol, alone or in combination, on postoperative pain management following ovariohysterectomy in dogs. Eighteen healthy female mixed-breed dogs, aged 1-2 years, weighed 16.7 ± 3.8 kg, were us... | Train | 3 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | [
1,
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0,
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] | 542 |
17,009,265 | Antiplatelet and anticoagulant therapy in patients with giant cell arteritis. | Vision loss and cerebrovascular accidents often complicate giant cell arteritis (GCA). Antiplatelet and anticoagulant therapy reduce the risk of stroke in other populations. We sought to determine whether antiplatelet or anticoagulant therapy reduces ischemic complications in patients with GCA. A retrospective chart re... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | [
1,
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1,
0
] | 544 |
12,195,132 | Risk of new-onset diabetes in the Losartan Intervention For Endpoint reduction in hypertension study. | There has been uncertainty about the risk of new-onset diabetes in hypertensive individuals treated with different blood pressure-decreasing drugs. To study this risk in hypertensive individuals who were at risk of developing diabetes mellitus in the Losartan Intervention For Endpoint reduction in hypertension (LIFE) s... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | [
1,
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1,
1,
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] | 545 |
2,243,877 | Comparison of flurbiprofen and alprazolam in the management of chronic pain syndrome. | A three-process model of chronic pain comprising tissue damage, anxiety, and depression is hypothesized. Within this model, the effectiveness of flurbiprofen (for analgesia) plus either alprazolam (for anxiety and depression) or placebo was evaluated in a randomized, double-blind trial with a single crossover. Flurbipr... | Train | 3 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | [
1,
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1,
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1,
0,
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] | 546 |
16,553,538 | The use of selective serotonin reuptake inhibitors in autism and related disorders. | This paper reviews the published literature on the use of selective serotonin reuptake inhibitors (SSRIs) for the treatment of symptoms associated with autistic disorder and other pervasive developmental disorders (PDDs) in both children and adults. To date, placebocontrolled studies of SSRIs have involved only fluvoxa... | Train | 3 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | [
1,
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1,
0,
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] | 547 |
21,995,339 | Increased risk of nontuberculous mycobacterial infection in asthmatic patients using long-term inhaled corticosteroid therapy. | The risk of pneumonia is increased among COPD patients using inhaled corticosteroids (ICS). However, there is uncertainty regarding the association between long-term use of ICS and exacerbations of respiratory tract infections among asthmatic patients. A case-control nested cohort study was performed to assess the asso... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | [
1,
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1,
1,
1,
1,
0
] | 548 |
26,708,640 | Acute Coronary Syndromes, Gastrointestinal Protection, and Recommendations Regarding Concomitant Administration of Proton-Pump Inhibitors (Omeprazol/Esomeprazole) and Clopidogrel. | The Food and Drug Administration and the European Medicines Agency sent a warning in 2010 discouraging the concomitant use of clopidogrel with omeprazole or esomeprazole. The purpose is to know the gastroprotective approach in patients with acute coronary syndrome (ACS) and the level of follow-up of the alert. In 17 ho... | Train | 3 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | [
1,
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1,
1,
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] | 550 |
2,005,078 | Efficacy and safety of morning versus evening fluoxetine administration. | A total of 120 patients who met DSM-III criteria for unipolar major depressive episode were equally randomized to fluoxetine a.m. or fluoxetine p.m. treatment groups, such that 30 patients were in each group at each of two sites. Patients received 20 to 80 mg of fluoxetine every day for 5 weeks; the dose was based on c... | Train | 3 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | [
1,
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1,
1,
0,
1,
1,
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] | 551 |
12,641,517 | The prophylactic use of a proton pump inhibitor before food and alcohol. | Patients report that the prophylactic consumption of a proton pump inhibitor minimizes gastrointestinal symptoms expected to be provoked by late-night food and alcohol consumption. The efficacy of this practice has not been studied formally. To perform a randomized, double-blind, placebo-controlled trial of a single do... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | [
1,
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] | 552 |
27,610,609 | Amoxicillin-clavulanate for patients with acute exacerbation of chronic rhinosinusitis: a prospective, double-blinded, placebo-controlled trial. | The management of acute exacerbation of chronic rhinosinusitis (AECRS) is still under debate, especially because there are no adequate studies to support a best-evidence treatment for this condition. Antibiotic use for AECRS has been recommended based on extrapolation of data from acute rhinosinusitis (ARS) or non-plac... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | [
1,
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1,
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1,
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] | 553 |
1,761,331 | Posture determines the nature of the interaction between angiotensin converting enzyme inhibitors and loop diuretics in patients with chronic cardiac failure. | The effects of inhibition of the renin angiotensin aldosterone system on the natriuretic and diuretic actions of an intravenous dose of frusemide 40 mg in patients with chronic cardiac failure maintained on oral diuretics were studied in the supine and erect positions. In the patients studied in the supine position the... | Train | 3 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | [
1,
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1,
0,
1,
0,
1
] | 554 |
29,212,311 | A Prospective Study on the Prevalence, Extent of Disease and Outcome of Eosinophilic Gastroenteritis in Patients Presenting with Lower Abdominal Symptoms. | The epidemiology of eosinophilic gastroenteritis remains unclear. We aim to determine the prevalence of eosinophilic gastroenteritis in patients with lower abdominal symptoms. In a prospective study, colonoscopy was performed on 2,469 consecutive patients. Biopsies were taken from the terminal ileum and ascending, tran... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | [
1,
1,
1,
1,
1,
0,
1,
0
] | 555 |
24,384,030 | Incidence and risk-factors of CHOP/R-CHOP-related cardiotoxicity in patients with aggressive non-Hodgkin's lymphoma. | The CHOP regimen with rituximab (R-CHOP) remains the standard for chemotherapy in patients with aggressive non-Hodgkin's lymphoma (NHL). The cardiotoxicity of doxorubicin appears to be a key problem in clinical practice. We studied the cardiotoxicity of CHOP/R-CHOP regimen in a retrospective series. The prognostic fact... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | [
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] | 556 |
8,040,490 | Clinical and cognitive effects of methylphenidate on children with attention deficit disorder as a function of aggression/oppositionality and age. | Children diagnosed with attention deficit disorder (ADD; n = 44), ADD plus aggression/oppositionality (ADD/O; n = 34), and as not meeting ADD criteria (NC; n = 29) received methylphenidate and placebo for 21 consecutive days each. Parents and teachers rated all groups improved under medication, but teachers reported le... | Train | 3 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | [
1,
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] | 557 |
22,244,574 | No evidence for an anti-inflammatory effect of escitalopram intervention in healthy individuals with a family history of depression. | Inflammation may contribute to the pathogenesis of depression and antidepressants are hypothesised to have an anti-inflammatory effect. In this randomised double-blinded trial we investigated the cytokine levels in supernatants of stimulated whole blood samples from first degree relatives to patients with depression ra... | Train | 3 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | [
1,
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1,
0,
1,
1,
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] | 558 |
12,238,622 | Post-partum cerebral angiopathy: repetitive TCD, MRI, MRA, and EEG examinations. | We report of a woman with post-partum cerebral angiopathy (PCA), in whom we repetitively performed transcranial Doppler sonography (TCD), MR imaging (MRI), and MR angiography (MRA) to evaluate the underlying pathophysiology. A 31-year-old woman, Gemini pregnant, complained of severe throbbing frontal headache four days... | Train | 3 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | [
1,
1,
1,
1,
0,
0,
0,
0
] | 559 |
21,813,592 | Oxidative stress is associated with liver damage, inflammatory status, and corticosteroid therapy in patients with systemic lupus erythematosus. | Oxidative stress exerts an important role on the pathophysiological mechanisms of systemic lupus erythematosus (SLE). This study investigated oxidative stress in patients with SLE and its correlation with disease activity, corticosteroid therapy, and liver function biomarkers. The study included 58 patients with SLE an... | Train | 3 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | [
1,
1,
1,
1,
0,
1,
1,
1
] | 560 |
24,035,645 | Pharmacological treatment of comorbid PTSD and substance use disorder: recent progress. | Previous research has identified a strong association between posttraumatic stress disorder (PTSD) and substance use disorder (SUD), necessitating the development of treatments that address both conditions. Some pharmacotherapies are effective for the treatment of PTSD and SUD alone, however; no medications have been p... | Train | 3 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | [
1,
0,
1,
0,
0,
1,
0,
1
] | 562 |
8,598,236 | Biweekly COP-BLAM (cyclophosphamide, vincristine, prednisone, bleomycin, doxorubicin and procarbazine) regimen combined with granulocyte colony stimulating factor (G-CSF) for intermediate-grade non-Hodgkin's lymphoma. | We evaluated the efficacy and adverse effects of biweekly COP-BLAM (cyclophosphamide, vincristine, prednisone, bleomycin, doxorubicin and procarbazine) therapy combined with granulocyte colony-stimulating factor (G-CSF) for treating non-Hodgkin's lymphoma (NHL). A complete remission was achieved in 65 (90.3%) of the 72... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | [
1,
1,
1,
1,
1,
1,
1,
0
] | 563 |
11,488,317 | Comparison of the acute effects of salbutamol and terbutaline on heart rate variability in adult asthmatic patients. | This study investigated the effects of beta2-adrenergic agonist therapy on heart rate variability (HRV) in adult asthmatic patients by using frequency domain measures of HRV. A randomized crossover design was used. Twenty adult patients with asthma were studied. All patients showed a mild-to-moderate decrease in baseli... | Train | 3 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | [
1,
1,
1,
1,
0,
1,
1,
0
] | 566 |
11,318,774 | Pharmacokinetics and systemic beta2-adrenoceptor-mediated responses to inhaled salbutamol. | To examine whether systemic beta2-adrenoceptor responses, such as tachycardia, tremor and hypokalaemia, can be used as a surrogate for the 20 min pharmacokinetic profile of inhaled salbutamol. A retrospective analysis of eight separate published studies in healthy volunteers was performed, each with an identical protoc... | Train | 3 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | [
1,
1,
1,
0,
1,
1,
1,
0
] | 567 |
2,654,045 | Differential psychopharmacology of methylphenidate and the neuropsychology of childhood hyperactivity. | The principle of rate-dependency has been proposed to explain the therapeutic effects of stimulant drugs in hyperactive children (HAC). This paper is a critical discussion of the salience of rate-dependency to childhood hyperactivity, on mathematical, theoretical and clinical levels. The results of a stimulant drug tri... | Train | 3 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | [
1,
0,
1,
0,
0,
1,
0,
0
] | 568 |
16,505,126 | Response of emotional unawareness after stroke to antidepressant treatment. | Unawareness of impairment (anosognosia) is a phenomenon associated with right hemisphere lesions. Unawareness of emotion has rarely been studied. Patients (N = 50) with poststroke major depression were administered the Toronto, Ontario, Canada, Alexithymia Scale to assess impairment in identifying feelings (F1), descri... | Train | 3 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | [
1,
1,
1,
1,
0,
1,
1,
0
] | 572 |
10,075,058 | Pharmacokinetic and pharmacodynamic effects of high-dose continuous intravenous verapamil infusion: clinical experience in the intensive care unit. | Our study aimed at evaluating the pharmacokinetic, cardiovascular, and metabolic effects of high-dose verapamil continuous intravenous infusion in cancer patients. Prospective clinical and pharmacokinetic study. Intensive care unit of a Cancer Research Institute. Nine patients (age range 31 to 57 yrs) with progressive ... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | [
1,
1,
1,
1,
1,
1,
1,
0
] | 574 |
7,867,381 | Chilblain lupus erythematosus (lupus pernio): clinical review of the Mayo Clinic experience and proposal of diagnostic criteria. | Five cases of chilblain lupus erythematosus were retrospectively reviewed regarding their clinical, histopathologic, serologic, and immunofluorescence findings. Ages at onset of chilblain lupus erythematosus varied from 26 to 73 years, with a female-to-male ratio of 3:2. Since other entities can be confused with this d... | Train | 3 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | [
1,
1,
1,
0,
0,
0,
0,
0
] | 575 |
3,541,320 | Hepatobiliary and pancreatic complications of cyclosporine therapy in 466 renal transplant recipients. | Two hundred twenty-eight patients from a total of 466 (49%) receiving renal allografts under cyclosporine/prednisone (CsA/Pred) immunosuppression experienced at least one episode of posttransplant hepatotoxicity. All patients were documented to have normal serum bilirubin, serum glutamic oxaloacetic transaminase (SGOT)... | Train | 3 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | [
1,
1,
1,
1,
0,
1,
1,
0
] | 576 |
9,972,586 | [Comparative naturalistic study of the efficacy and tolerability of new antidepressants]. | The objective of this study was to compare, in a naturalistic setting, the efficacy and tolerability of currently available Selective Serotonin Re-uptake Inhibitors (SSRIs) and venlafaxine in out-patients from a primary psychiatric-care center. The sample was composed of 194 patients with mood disorders (major depressi... | Train | 3 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | [
1,
1,
1,
1,
0,
1,
1,
0
] | 577 |
16,098,392 | Increased long term rates of stent thrombosis and mortality in patients given clopidogrel as compared to ticlopidine following coronary stent implantation. | Clopidogrel has largely replaced ticlopidine following coronary stent implantation. Recently, concern has been raised regarding the possibility of excess long term mortality in patients given clopidogrel rather than ticlopidine following coronary stenting. We studied 1519 consecutive patients who underwent 2020 stent i... | Train | 3 | 1 | 0 | 1 | 0 | 1 | 1 | 1 | 0 | [
1,
0,
1,
0,
1,
1,
1,
0
] | 578 |
22,103,958 | Why two smoking cessation agents work better than one: role of craving suppression. | This research examined why smokers receiving combination medication for smoking cessation are more likely to quit smoking than are those who receive either single agent (monotherapy) or placebo. Data were collected from 1,504 current smokers (58.2% women, 83.9% White; mean age = 44.67 years, SD = 11.08) participating i... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | [
1,
1,
1,
1,
1,
1,
1,
1
] | 579 |
35,883,066 | Dynamics of gut microbiota during pregnancy in women with TPOAb-positive subclinical hypothyroidism: a prospective cohort study. | Anti-thyroid peroxidase antibody (TPOAb) positivity can contribute to inhibit thyroxine synthesis. Gut microbiota can interact with metabolic or immune diseases. However, dynamics of gut microbiota from the second (T2) to the third trimester (T3) in women with TPOAb-positive/negative subclinical hypothyroidism (TPOAb<s... | Train | 3 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | [
1,
1,
1,
1,
0,
1,
1,
0
] | 580 |
22,955,351 | The innovative potential of Lactobacillus rhamnosus LR06, Lactobacillus pentosus LPS01, Lactobacillus plantarum LP01, and Lactobacillus delbrueckii Subsp. delbrueckii LDD01 to restore the "gastric barrier effect" in patients chronically treated with PPI: a pilot study. | Gastroesophageal reflux disease is a very widespread condition. In Europe, it is estimated that about 175 million people suffer from this disease and have to chronically take drugs to increase gastric pH. The proton pump inhibitors (PPIs) such as omeprazole, lansoprazole, and esomeprazole are the most widely used drug ... | Train | 3 | 1 | 1 | 1 | 0 | 0 | 1 | 1 | 0 | [
1,
1,
1,
0,
0,
1,
1,
0
] | 581 |
12,640,185 | Severe autoimmune cytopenias in treatment-naive hepatitis C virus infection: clinical description of 35 cases. | To determine the clinical characteristics and outcome of patients with chronic hepatitis C virus (HCV) infection presenting severe autoimmune cytopenia unrelated to interferon alpha therapy, we analyzed characteristics and outcomes of 35 patients with HCV (16 from our departments and 19 from the literature). We conside... | Train | 3 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | [
1,
1,
1,
1,
0,
0,
1,
0
] | 583 |
8,612,115 | Effects of theophylline and ipratropium on cognition in elderly patients with chronic obstructive pulmonary disease. | To determine whether chronic therapy with theophylline or ipratropium has an adverse effect on cognition and psychomotor skills in geriatric patients with chronic obstructive pulmonary disease. The study design was a randomized, repeated measures, double-blind, double-dummy, placebo-controlled comparison of theophyllin... | Train | 3 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | [
1,
1,
1,
1,
0,
1,
0,
1
] | 584 |
20,021,539 | Efficacy of combination drug pulse therapy in maintaining lipid levels in patients intolerant of daily statin use. | The objective of this study was to evaluate the efficacy of combination drug pulse therapy in maintaining lipid levels in patients intolerant of a daily dose of statins. Twenty-three patients, previously receiving aggressive statin therapy, were treated twice weekly with rosuvastatin or atorvastatin in different dosage... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | [
1,
1,
1,
1,
1,
1,
1,
1
] | 585 |
21,350,303 | Glucose-lowering effect of colestimide is associated with baseline HbA1c in type 2 diabetic patients with hypercholesterolemia. | We previously reported that colestimide, an anion exchange resin, improved glycemic control in patients with type 2 diabetes. However, the factors associated with the decrease of HbA1c remain unclear. In present study, we retrospectively compared glycemic control between groups receiving colestimide (n=71), atorvastati... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | [
1,
1,
1,
1,
1,
1,
1,
0
] | 586 |
27,641,263 | Assessment of Dual-Antiplatelet Regimen for Pipeline Embolization Device Placement: A Survey of Major Academic Neurovascular Centers in the United States. | Flow diversion with the Pipeline Embolization Device (PED) currently is adopted for treatment of a variety of intracranial aneurysms. The elevated risk of thromboembolic complications associated with the device necessitates the need for administration of antiplatelet agents. We sought to assess current dual-antiplatele... | Train | 3 | 1 | 1 | 1 | 0 | 0 | 1 | 1 | 0 | [
1,
1,
1,
0,
0,
1,
1,
0
] | 587 |
22,734,071 | A phase 2 trial of standard-dose cyclophosphamide, doxorubicin, vincristine, prednisone (CHOP) and rituximab plus bevacizumab for patients with newly diagnosed diffuse large B-cell non-Hodgkin lymphoma: SWOG 0515. | S0515 was a phase 2 trial to determine whether the addition of bevacizumab to cyclophosphamide, doxorubicin, vincristine, prednisone (CHOP) plus rituximab (R-CHOP) would improve progression-free survival (PFS) without adding significant toxicity in patients with newly diagnosed advanced diffuse large B-cell lymphoma. A... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | [
1,
1,
1,
1,
1,
1,
1,
1
] | 588 |
19,577,224 | What you believe is what you want: modeling PTSD-related treatment preferences for sertraline or prolonged exposure. | Despite the known efficacy of various psychotherapies and pharmacotherapies for posttraumatic stress disorder (PTSD), we know little about what factors predict treatment preference. In the present study, we first developed exploratory path models of treatment preference for a psychotherapy or pharmacotherapy (n=273) an... | Train | 3 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | [
1,
1,
1,
0,
0,
0,
1,
0
] | 589 |
12,814,852 | A method for controlling for a high placebo response rate in a comparison of venlafaxine XR and diazepam in the short-term treatment of patients with generalised anxiety disorder. | This randomised, double-blind, placebo-controlled study compared the efficacy of venlafaxine XR (75 or 150 mg/d) with diazepam (15 mg/d) over an 8-week treatment period in 540 non-depressed outpatients with generalised anxiety disorder (GAD). At week 8, significant improvements from baseline were observed in the venlaf... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | [
1,
1,
1,
1,
1,
1,
1,
1
] | 590 |
30,304,103 | The effect of levothyroxine treatment on left ventricular function in subclinical hypothyroidism. | Treatment of subclinical hypothyroidism (ScH), especially the mild form of ScH, is controversial because thyroid hormones influence cardiac function. We investigate left ventricular systolic and diastolic function in ScH and evaluate the effect of 5-month levothyroxine treatment. Fifty-four patients with newly diagnose... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | [
1,
1,
1,
1,
1,
1,
1,
1
] | 592 |
33,243,802 | Proton pump inhibitor utilisation and potentially inappropriate prescribing analysis: insights from a single-centred retrospective study. | This study aimed to characterise the prescribing patterns and evaluate the appropriateness of the prescribed proton pump inhibitors (PPIs) in adult patients via a review of electronic medical records in a single-centred hospital. All patients admitted to the outpatient department of Jinshan Hospital, Fudan University, ... | Train | 3 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | [
1,
1,
0,
1,
0,
1,
1,
0
] | 593 |
11,605,121 | [RC-Cornet(R) improves the bronchodilating effect of Ipratropiumbromide (Atrovent(R)) inhalation in COPD-patients]. | In 35 patients with severe COPD and tracheal-bronchial instability the bronchodilatory effect of salbutamol (Salbulair(R) Autohaler) was tested prospectively, randomized and crossover on two consecutive days by bodyplethysmography. Following the salbutamol inhalation, the effect of ipratropiumbromide inhalation (by Par... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | [
1,
1,
1,
1,
1,
1,
1,
1
] | 594 |
20,108,200 | Effects of duloxetine in treatment-refractory men with posttraumatic stress disorder. | Although there is evidence that selective serotonin reuptake inhibitors provide some benefit in the treatment of post-traumatic stress disorder (PTSD), most meta-analytical reviews have concluded that effect sizes are small and, moreover, that there may be relatively little benefit for some populations (e. g., combat v... | Train | 3 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | [
1,
1,
1,
1,
0,
1,
1,
0
] | 595 |
21,940,824 | Anti-Escherichia coli asparaginase antibody levels determine the activity of second-line treatment with pegylated E coli asparaginase: a retrospective analysis within the ALL-BFM trials. | Hypersensitivity reactions limit the use of the antileukemic enzyme asparaginase (ASE). We evaluated Ab levels against Escherichia coli ASE and ASE activity in 1221 serum samples from 329 patients with acute lymphoblastic leukemia who had received ASE treatment according to the ALL-BFM 2000 or the ALL-REZ BFM 2002 prot... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | [
1,
1,
1,
1,
1,
1,
1,
0
] | 596 |
21,292,644 | Randomized comparison of pegfilgrastim day 4 versus day 2 for the prevention of chemotherapy-induced leukocytopenia. | To study the effects of deferring pegfilgrastim until day 4 on the reduction of chemotherapy-induced leukocytopenia. Patients of age 61-80 years with aggressive lymphoma were randomly assigned to receive 6 mg pegfilgrastim on day 2 or 4 of a 2-week chemotherapy regimen (R-CHOP-14). Two hundred and ninety-two and 313 ch... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | [
1,
1,
1,
1,
1,
1,
1,
1
] | 597 |
11,402,629 | Montelukast dose selection in children ages 2 to 5 years: comparison of population pharmacokinetics between children and adults. | Montelukast, a leukotriene receptor antagonist, has demonstrated efficacy and tolerability in the treatment of asthma in patients age 6 years and older. The purpose of this open, one-period, multicenter population pharmacokinetic study was to identify a chewable tablet (CT) dose of montelukast for administration to chi... | Train | 3 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | [
1,
1,
1,
1,
0,
1,
0,
0
] | 598 |
26,672,898 | Plasma levels of direct oral anticoagulants in real life patients with atrial fibrillation: Results observed in four anticoagulation clinics. | Direct oral anticoagulant (DOAC) intra- and inter-individual variability was previously reported, but its magnitude is still considered negligible for patient management. To evaluate inter- and intra-individual variability in real-world atrial fibrillation patients on dabigatran, rivaroxaban or apixaban in four Italian... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | [
1,
1,
1,
1,
1,
1,
1,
0
] | 600 |
29,754,646 | Effect of carvedilol vs metoprolol succinate on mortality in heart failure with reduced ejection fraction. | Beta blocker therapy is indicated in all patients with heart failure with reduced ejection fraction (HFrEF) as per current guidelines. The relative benefit of carvedilol to metoprolol succinate remains unknown. This study aimed to compare survival benefit of carvedilol to metoprolol succinate. The VA's databases were q... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | [
1,
1,
1,
1,
1,
1,
1,
0
] | 601 |
11,838,624 | Comparative efficacy of SSRIs and amisulpride in burning mouth syndrome: a single-blind study. | Although a significant amount of evidence indicates the efficacy of some antidepressants in treating psychogenic pain and somatoform disorder, very few studies have investigated their possible therapeutic action in burning mouth syndrome (BMS). The purpose of this 8-week, single-blind study was to provide preliminary d... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | [
1,
1,
1,
1,
1,
1,
1,
0
] | 602 |
24,010,587 | The postoperative bleeding rate and its risk factors in patients on antithrombotic therapy who undergo gastric endoscopic submucosal dissection. | There is a lack of consensus regarding the risk of postoperative hemorrhage in patients on antithrombotic therapy who undergo endoscopic submucosal dissection (ESD).We examined postoperative bleeding rates and risk factors for postoperative hemorrhage from post-ESD gastric ulcers in patients on antithrombotic therapy. ... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | [
1,
1,
1,
1,
1,
1,
1,
1
] | 603 |
31,778,146 | Non-vitamin K antagonist oral anticoagulants and warfarin in atrial fibrillation patients with concomitant peripheral artery disease. | To investigate the effectiveness, safety, and outcomes of lower limb events for non-vitamin K antagonist oral anticoagulants (NOACs) vs. warfarin among atrial fibrillation (AF) patients with concomitant peripheral artery disease (PAD). In this nationwide retrospective cohort study collected from Taiwan National Health ... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | [
1,
1,
1,
1,
1,
1,
1,
1
] | 604 |
16,476,149 | Genetic, developmental and personality correlates of self-mutilation in depressed patients. | To examine whether the T allele of G protein beta3 (GNbeta3) is associated with self-mutilation in depressed patients. A history of self-mutilation was systematically inquired about when recruiting depressed patients for a long-term treatment trial. Risk factors such as borderline personality disorder and childhood abu... | Train | 3 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | [
1,
1,
1,
1,
0,
0,
0,
0
] | 605 |
1,487,553 | A study in normal human volunteers to compare the rate and extent of levothyroxine absorption from Synthroid and Levoxine. | Numerous branded and generic formulations of levothyroxine (LT4) sodium tablets are currently available. Results from previous studies attempting to examine the comparative bioavailability of these formulations are difficult to interpret because of subject heterogeneity, single time-point blood sampling, varying degree... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | [
1,
1,
1,
1,
1,
1,
1,
1
] | 606 |
26,279,153 | Retrospective analysis for treatment of naïve canine multicentric lymphoma with a 15-week, maintenance-free CHOP protocol. | Standard of care treatment of dogs with multicentric lymphoma includes combination chemotherapy with cyclophosphamide, doxorubicin, vincristine and prednisone (CHOP); however, owners may be hesitant to commit the resources necessary to complete a lengthy, multi-drug protocol. One hundred thirty-four client-owned dogs w... | Train | 3 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | [
1,
0,
1,
1,
1,
1,
1,
0
] | 607 |
30,978,536 | Combination of Bismuth and Standard Triple Therapy Eradicates Helicobacter pylori Infection in More than 90% of Patients. | Due to the poor eradication rates of standard triple therapy, the addition of bismuth salts has been proposed for first-line eradication of Helicobacter pylori. We assessed the effectiveness and safety of the combination of bismuth and the standard, clarithromycin-containing triple therapy in eradication of H pylori in... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | [
1,
1,
1,
1,
1,
1,
1,
0
] | 609 |
15,715,811 | Psychostimulant treatment of adults with mental retardation and attention-deficit hyperactivity disorder. | To examine the potential effectiveness and tolerability of psychostimulants in adults with mental retardation (MR) and attention-deficit hyperactivity disorder (ADHD). A retrospective chart review was conducted in a clinic specialized in treating individuals with developmental disabilities. Improvement was assessed usi... | Train | 3 | 1 | 1 | 1 | 0 | 0 | 1 | 1 | 0 | [
1,
1,
1,
0,
0,
1,
1,
0
] | 610 |
8,667,090 | Implementation of local guidelines for cost-effective management of hypertension. A trial of the firm system. | To evaluate the effects of an intensive intervention to implement guidelines for cost-effective management of hypertension on medication use and cost, blood pressure control, and other resource use. Retrospective cohort trial based on the Cleveland Veterans' Affairs Medical Center Firm System. General internal medicine... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | [
1,
1,
1,
1,
1,
1,
1,
1
] | 611 |
23,952,746 | A comparative study of bivalirudin plus clopidogrel versus bivalirudin plus prasugrel in primary angioplasty using propensity score matching. | In primary angioplasty, bivalirudin is superior to treatment with heparin plus glycoprotein inhibitors for reducing cardiovascular events, although bivalirudin increases the risk of stent thrombosis. Our hypothesis is that the use of prasugrel plus bivalirudin in primary angioplasty would reduce stent thrombosis and ca... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | [
1,
1,
1,
1,
1,
1,
1,
1
] | 612 |
32,612,180 | Comparison of uric acid reduction and renal outcomes of febuxostat vs allopurinol in patients with chronic kidney disease. | Whether the clinical trial treatment effect of urate-lowering therapy (ULT) in patient with chronic kidney disease (CKD) is generalizable to real-word settings is unclear. This study aimed to compare febuxostat with allopurinol for uric acid reduction and renal protection in patients with CKD. Adult CKD patients newly ... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | [
1,
1,
1,
1,
1,
1,
1,
1
] | 613 |
21,255,198 | Treatment of depressive symptoms in Parkinson's disease. | Significant depressive disorders are present in approximately 30-40% of patients with Parkinson's disease (PD). Depressive symptoms are correlated with poor health-related quality-of-life (HRQoL) scores, and are the major determinant of HRQoL. Studies that have evaluated pharmacotherapy for depressive symptoms in PD ha... | Train | 3 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | [
1,
1,
1,
1,
0,
1,
0,
1
] | 614 |
15,682,244 | Randomized controlled trial of standard versus double dose cotrimoxazole for childhood pneumonia in Pakistan. | Increasing concern over bacterial resistance to cotrimoxazole, which is recommended by WHO as a first-line drug for treating non-severe pneumonia, led to the suggestion that this might not be optimal therapy. However, changing to alternative antimicrobial agents, such as amoxicillin, is costly. We compared the clinical... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | [
1,
1,
1,
1,
1,
1,
1,
1
] | 615 |
1,490,690 | Improvement of glucose tolerance by minimal doses of glipizide in obese subjects with different degrees of glucose intolerance. | Obesity and impaired glucose tolerance (IGT) are risk factors for non insulin dependent diabetes mellitus (NIDDM) and for ischemic heart disease. Long term treatment of IGT subjects with diet and tolbutamide prevents progression of IGT to NIDDM. We have evaluated the lowest dose of glipizide, a second-generation sulfon... | Train | 3 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | [
1,
1,
1,
1,
0,
1,
1,
0
] | 619 |
29,953,682 | Pharmacogenetic evaluation of a DISP1 gene variant in antidepressant treatment of obsessive-compulsive disorder. | A recent genome-wide association study (GWAS) in obsessive-compulsive disorder (OCD) reported a significant marker in the dispatched homolog 1 (Drosophila) gene (DISP1 gene) associated with serotonin reuptake inhibitor (SRI) antidepressant response (Qin et al., ). DISP1 has never been examined before in terms of associ... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | [
1,
1,
1,
1,
1,
1,
1,
0
] | 620 |
15,362,794 | Evaluation of the effects of Helicobacter pylori eradication therapy on gastric antral epithelial hyperproliferation: a prospective six-month follow-up study. | H. pylori-induced hyperproliferation of the gastric epithelium may have a critical role in gastric carcinogenesis. H. pylori-related hyperproliferation and reversibility of hyperproliferation after eradication therapy is still controversial. Therefore, we have evaluated the effects of H. pylori and its eradication on g... | Train | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | [
1,
1,
1,
1,
1,
1,
1,
1
] | 621 |
26,369,402 | Canine epidermolysis bullosa acquisita: a retrospective study of 20 cases. | Epidermolysis bullosa acquisita (EBA) is a rare autoimmune subepidermal blistering disease of dogs and humans. Our objectives were to describe clinical phenotypes, histopathology and treatment outcomes of canine EBA. Twenty dogs diagnosed with EBA based on a subepidermal blister formation and collagen VII autoreactivit... | Train | 3 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | [
1,
0,
1,
1,
1,
1,
1,
0
] | 623 |
9,192,541 | Cardiovascular effects of tricyclic antidepressants in childhood asthma: a case series and review. | Children with asthma frequently have significant anxiety and depression that interfere with treatment outcome. Although the use of antidepressants may be helpful, in the one published study of antidepressant use in pediatric asthma, significant side effects necessitated discontinuance; these side effects were increased... | Train | 3 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | [
1,
1,
1,
1,
0,
1,
1,
0
] | 624 |
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