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Neuromuscular blocking drugs are often classified into two broad classes:
*Pachycurares, which are bulky molecules with nondepolarizing activity
*Leptocurares, which are thin and flexible molecules that tend to have depolarizing activity.
It is also common to classify them based on their chemical structure.
*Acetylchol... | 0 | Neurochemistry |
Some ion channels are classified by the duration of their response to stimuli:
*Transient receptor potential channels: This group of channels, normally referred to simply as TRP channels, is named after their role in Drosophila visual phototransduction. This family, containing at least 28 members, is diverse in its mec... | 0 | Neurochemistry |
Coelenterazine can be crystallized into orange-yellow crystals. The molecule absorbs light in the ultraviolet and visible spectrum, with peak absorption at 435 nm in methanol, giving the molecule a yellow color. The molecule spontaneously oxidizes in aerobic conditions or in some organic solvents such as dimethylformam... | 1 | Bioluminescence |
* AM404 – an active metabolite of paracetamol.
* AM1172
* LY-2183240
* O-2093
* OMDM-2
* UCM-707
* VDM-11
* Guineensine
*WOBE437 and RX-055 | 0 | Neurochemistry |
Traumatic brain injury is defined as a “direct physical impact or trauma to
the head followed by a dynamic series of injury and repair events”. Recently, neuroproteomics have been applied to studying the disability that over 5.4 million Americans live with. In addition to physically injuring the brain tissue, traumat... | 0 | Neurochemistry |
The first type of photocyte granule has been found to contain between two and twelve microtubules. In addition, the matrix of the type I granule lacks a uniform shape or structure with ferritin distributed throughout. | 1 | Bioluminescence |
Bioluminescence is produced by the dinoflagellate Pyrodinium bahamense, which glows blue when agitated. Although the phytoplankton responsible for the phenomenon of bioluminescence is found throughout the Antilles, Puerto Mosquito is one of the seven year-round bioluminescent bays in the Caribbean. The bioluminescence ... | 1 | Bioluminescence |
Fish generally use bioluminescence for camouflage to hide from predators. Endogenous photocytes are more commonly used for bioluminescence than other means like bacteria. Some fish may use the bioluminescence produced by their photocytes as a means of communication. | 1 | Bioluminescence |
*Chloride channels: This superfamily of channels consists of approximately 13 members. They include ClCs, CLICs, Bestrophins and CFTRs. These channels are non-selective for small anions; however chloride is the most abundant anion, and hence they are known as chloride channels.
*Potassium channels
**Voltage-gated potas... | 0 | Neurochemistry |
The dysfunction of potassium channels, including SK channels, is thought to play a role in the pathogenesis of Parkinson's disease (PD), a progressive neurodegenerative disorder.
SK channel blockers control the firing rate (the number of action potentials produced by a neuron in a given time) and the firing pattern (th... | 0 | Neurochemistry |
Patients receiving chronic treatment are relatively resistance to nondepolarising NMBAs due to the accelerated clearance. | 0 | Neurochemistry |
K2.3 is found in the central nervous system (CNS), muscle, liver, pituitary, prostate, kidney, pancreas and vascular endothelium tissues. K2.3 is most abundant in regions of the brain, but has also been found to be expressed in significant levels in many other peripheral tissues, particularly those rich in smooth muscl... | 0 | Neurochemistry |
The phenomenon is known as mareel in Shetland. This term is derived from the Norn word *mareld, which is itself derived from the Old Norse word mǫrueldr, which is a compound of marr (mere, sea) and eldr (fire).
In the Somali language it is called “Kaluunka Iftiima”. The term translates to glowing sea creatures or glowi... | 1 | Bioluminescence |
Apoaequorin is an ingredient in "Prevagen", which is marketed by Quincy Bioscience as a memory supplement. In 2017, the US Federal Trade Commission (FTC) charged the maker with falsely advertising that the product improves memory, provides cognitive benefits, and is "clinically shown" to work. According to the FTC, "th... | 1 | Bioluminescence |
Vargulin is oxidized by the Vargula luciferase, a 62 kDa enzyme, to produce blue light at 462 nm (max emission, detected with a 425 to 525 nm filter).
The vargulin does not cross react with luciferases using coelenterazine or Firefly luciferin. | 1 | Bioluminescence |
The channelosome (not to be confused with "channelome") is the collection of (usually) signalling proteins associated with an ion channel. The channelosome is frequently clustered within a lipid microdomain or caveolae. This collection of proteins may be involved with anchoring, phosphorylation or some other modulat... | 0 | Neurochemistry |
Lithium is structurally similar to other cations such as sodium, potassium, magnesium and calcium, this causes lithium to activate potassium channels which inhibit neuromuscular transmission. Patients who take lithium can have a prolonged response to both depolarising and nondepolarising NMBAs. | 0 | Neurochemistry |
SK channels (small conductance calcium-activated potassium channels) are a subfamily of calcium-activated potassium channels. They are so called because of their small single channel conductance in the order of 10 pS. SK channels are a type of ion channel allowing potassium cations to cross the cell membrane and are ac... | 0 | Neurochemistry |
All bacterial luciferases are approximately 80 KDa heterodimers containing two subunits: α and β. The α subunit is responsible for light emission. The luxA and luxB genes encode for the α and β subunits, respectively. In most bioluminescent bacteria, the luxA and luxB genes are flanked upstream by luxC and luxD and dow... | 1 | Bioluminescence |
Dinoflagellate luciferin is a chlorophyll derivative (i. e. a tetrapyrrole) and is found in some dinoflagellates, which are often responsible for the phenomenon of nighttime glowing waves (historically this was called phosphorescence, but is a misleading term). A very similar type of luciferin is found in some types of... | 1 | Bioluminescence |
Records of bioluminescence due to bacteria have existed for thousands of years. They appear in the folklore of many regions, including Scandinavia and the Indian subcontinent. Both Aristotle and Charles Darwin have described the phenomenon of the oceans glowing. Since its discovery less than 30 years ago, the enzyme lu... | 1 | Bioluminescence |
It has been concluded that acetylcholine and related compounds must be in the gauche (bent) configuration when bound to the nicotinic receptor. Beers and Reich's studies on cholinergic receptors in 1970 showed a relationship affecting whether a compound was muscarinic or nicotinic. They showed that the distance from th... | 0 | Neurochemistry |
The main advantage of FbFPs over GFP is their independence of molecular oxygen. Since all GFP derivatives and homologues require molecular oxygen for the maturation of their chromophore, these fluorescent proteins are of limited use under anaerobic or hypoxic conditions.
Since FbFPs bind FMN as chromophore, which is s... | 1 | Bioluminescence |
The endocannabinoid system, broadly speaking, includes:
* The endogenous arachidonate-based lipids, anandamide (N-arachidonoylethanolamide) and 2-AG, besides other N-acylethanolamines (NAEs); these are known as "endocannabinoids" and are physiological ligands for the cannabinoid receptors. Endocannabinoids are all eic... | 0 | Neurochemistry |
Allosteric modulators of small SK channels work by changing the apparent calcium sensitivity of the channels. Examples include:
* Riluzole
* Non-selective positive modulators of SK channels: EBIO (1-Ethyl-2-BenzimIdazolinOne), NS309 (6,7-dichloro-1H-indole-2,3-dione 3-oxime)
* SK-2 and SK-3 selective positive modulato... | 0 | Neurochemistry |
While the secretion of glucocorticoids in response to stressful stimuli is an adaptive response necessary for an organism to respond appropriately to a stressor, persistent secretion may be harmful. The endocannabinoid system has been implicated in the habituation of the hypothalamic-pituitary-adrenal axis (HPA axis) t... | 0 | Neurochemistry |
The helicoradian (Loreyu in Navi) is a carnivorous plant that has red spiral-leaves. The plants are up to tall and, when touched, instantly curl and collapse into themselves. They are zooplantae, part animal, part plant. They are first seen when Jake wanders off into a forest of helicoradia and touches multiple leaves... | 1 | Bioluminescence |
In the 1920s, the Russian embryologist Alexander Gurwitsch reported "ultraweak" photon emissions from living tissues in the UV-range of the spectrum. He named them "mitogenetic rays" because his experiments convinced him that they had a stimulating effect on cell division.
In the 1970s Fritz-Albert Popp and his researc... | 1 | Bioluminescence |
Mice treated with tetrahydrocannabinol (THC) show suppression of long-term potentiation in the hippocampus, a process that is essential for the formation and storage of long-term memory. These results may concur with anecdotal evidence suggesting that smoking cannabis impairs short-term memory. Consistent with this f... | 0 | Neurochemistry |
The photocyte of Arachnocampa luminosa was found to contain a circular nucleus, and large amounts of ribosomes, smooth endoplasmic reticulum, mitochondria, and microtubules. Instead of having photocyte granules, the photocytes of the organism were shown to undergo the luciferase reaction in their cytoplasm. The cells d... | 1 | Bioluminescence |
The term photoprotein was first used to describe the unusual chemistry of the luminescent system of Chaetopterus (a marine Polychaete worm). This was meant to distinguish them from other light-producing proteins because these do not exhibit the usual luciferin-luciferase reaction. | 1 | Bioluminescence |
This study examined the clinical history of the CSF and urine of two Greek siblings who were both diagnosed with SR deficiency. Both siblings displayed delayed psychomotor development and a movement disorder. The diagnosis was confirmed by measuring the SR enzyme activity and mutation analysis. The mutation analysis of... | 0 | Neurochemistry |
One group of researchers applied the field of neuroproteomics to examine how different proteins affect the initial growth of neuritis. The experiment compared the protein activity of control neurons with the activity of neurons treated with nerve growth factor (NGF) and JNJ460, an “immunophilin ligand.” JNJ460 is an ... | 0 | Neurochemistry |
Luciferase is a generic term for the class of oxidative enzymes that produce bioluminescence, and is usually distinguished from a photoprotein. The name was first used by Raphaël Dubois who invented the words luciferin and luciferase, for the substrate and enzyme, respectively. Both words are derived from the Latin wor... | 1 | Bioluminescence |
An opioidergic agent (or drug) is a chemical which functions to directly modulate the opioid neuropeptide systems (i.e., endorphin, enkephalin, dynorphin, nociceptin) in the body or brain. Examples include opioid analgesics such as morphine and opioid antagonists such as naloxone. Opioidergics also comprise allosteric ... | 0 | Neurochemistry |
Vargulin, also called Cypridinid luciferin, Cypridina luciferin, or Vargula luciferin, is the luciferin found in the ostracod Cypridina hilgendorfii, also named Vargula hilgendorfii. These bottom dwelling ostracods emit a light stream into water when disturbed presumably to deter predation. Vargulin is also used by the... | 1 | Bioluminescence |
It is commonly known that drug addiction involves permanent synaptic plasticity of various neuronal circuits. Neuroproteomics is being applied to study the effect of drug addiction across the synapse. Research is being conducted by isolating distinct regions of the brain in which synaptic transmission takes place and... | 0 | Neurochemistry |
Firefly luciferase is the light-emitting enzyme responsible for the bioluminescence of fireflies and click beetles. The enzyme catalyses the oxidation of firefly luciferin, requiring oxygen and ATP. Because of the requirement of ATP, firefly luciferases have been used extensively in biotechnology. | 1 | Bioluminescence |
:For a synthetic analogue see also 3,5-Difluoro-4-hydroxybenzylidene imidazolinone.
Mechanistically, the process involves base-mediated cyclization followed by dehydration and oxidation. In the reaction of 7a to 8 involves the formation of an enamine from the imine, while in the reaction of 7b to 9 a proton is abstract... | 1 | Bioluminescence |
A natural neuroactive substance (NAS) is a chemical synthesized by neurons that affects the actions of other neurons or muscle cells. Natural neuroactive substances include neurotransmitters, neurohormones, and neuromodulators. Neurotransmitters work only between adjacent neurons through synapses. Neurohormones are ... | 0 | Neurochemistry |
Neuromelanin gives specific brain sections, such as the substantia nigra or the locus coeruleus, distinct color. It is a type of melanin and similar to other forms of peripheral melanin. It is insoluble in organic compounds, and can be labeled by silver staining. It is called neuromelanin because of its function and th... | 0 | Neurochemistry |
Many new monomeric versions of EosFP have been developed that offer advantages over wild type EosFP. Developed by a team at the Janelia Farm Research Campus at Howard Hughes Medical Institute, mEos4 has higher photostability and longer imaging abilities than EosFP. It is also highly resistant to chemical fixatives suc... | 1 | Bioluminescence |
The L-alanine derivative β-methylamino-L-alanine (BMAA) has long been identified as a neurotoxin which was first associated with the amyotrophic lateral sclerosis/parkinsonism–dementia complex (Lytico-bodig disease) in the Chamorro people of Guam. The widespread occurrence of BMAA can be attributed to cyanobacteria whi... | 0 | Neurochemistry |
LncRNA has evolved rather recently from those of other species but still maintains some functionality. With regards to this specific form, researchers believe that it can serve as a diagnostic and predictive biomarker for cancers where its normal expression is altered. Much work is still required to fully understand th... | 0 | Neurochemistry |
The availability of GFP and its derivatives has thoroughly redefined fluorescence microscopy and the way it is used in cell biology and other biological disciplines. While most small fluorescent molecules such as FITC (fluorescein isothiocyanate) are strongly phototoxic when used in live cells, fluorescent proteins suc... | 1 | Bioluminescence |
Aequorin is a holoprotein composed of two distinct units, the apoprotein that is called apoaequorin, which has an approximate molecular weight of 21 kDa, and the prosthetic group coelenterazine, the luciferin. This is to say, apoaequorin is the enzyme produced in the photocytes of the animal, and coelenterazine is the ... | 1 | Bioluminescence |
In Avatar, the Navi are an indigenous species that live on Pandora. They are humanoid in appearance and are tall, having pairs of eyes, ears, arms, legs and feet like humans, as well as a nose, a mouth, and expressions recognizable to humans. The Navi differ from humans in having blue striped skin, pointed and mobile ... | 1 | Bioluminescence |
Neurotrophin mimetics are small molecules or peptide like molecules that can modulate the action of the neurotrophin receptor.
One of the main causes of neurodegeneration involves changes in the expression of neurotrophins (NTs) and/or their receptors (TrkA, TrkB, TrkC and p75NTR). Indeed, these imbalances or changes i... | 0 | Neurochemistry |
The first PAFP, Kaede (protein), was isolated from Trachyphyllia geoffroyi in a cDNA library screen designed to identify new fluorescent proteins. A fluorescent green protein derived from this screen was serendipitously discovered to have sensitivity to ultraviolet light-- | 1 | Bioluminescence |
Firefly luciferin is the luciferin found in many Lampyridae species. It is the substrate of beetle luciferases (EC 1.13.12.7) responsible for the characteristic yellow light emission from fireflies, though can cross-react to produce light with related enzymes from non-luminous species. The chemistry is unusual, as aden... | 1 | Bioluminescence |
A thorough review of trace amine-associated receptors that discusses the historical evolution of this research particularly well is that of Grandy. | 0 | Neurochemistry |
There are over 300 types of ion channels just in the cells of the inner ear. Ion channels may be classified by the nature of their gating, the species of ions passing through those gates, the number of gates (pores), and localization of proteins.
Further heterogeneity of ion channels arises when channels with different... | 0 | Neurochemistry |
James Camerons core idea for the Avatars fictional creatures was for them to be "superslick and aerodynamic, and be like a race car with racing stripes". Neville Page worked on Avatar as the lead creature designer. He, Wayne Barlowe (author, artist, and initial lead creature designer), and Yuri Bartoli (concept designe... | 1 | Bioluminescence |
Due to the potential for widespread usage and the evolving needs of researchers, many different mutants of GFP have been engineered. The first major improvement was a single point mutation (S65T) reported in 1995 in Nature by Roger Tsien. This mutation dramatically improved the spectral characteristics of GFP, resultin... | 1 | Bioluminescence |
The effect of non-depolarizing neuromuscular-blocking drugs may be reversed with acetylcholinesterase inhibitors, neostigmine, and edrophonium, as commonly used examples. Of these, edrophonium has a faster onset of action than neostigmine, but it is unreliable when used to antagonize deep neuromuscular block. Acetylcho... | 0 | Neurochemistry |
Since these drugs may cause paralysis of the diaphragm, mechanical ventilation should be at hand to provide respiration.
In addition, these drugs may exhibit cardiovascular effects, since they are not fully selective for the nicotinic receptor and hence may have effects on muscarinic receptors. If nicotinic receptors ... | 0 | Neurochemistry |
Foxfire is the bioluminescence created by some species of fungi present in decaying wood. While there may be multiple different luciferins within the kingdom of fungi, 3-hydroxy hispidin was determined to be the luciferin in the fruiting bodies of several species of fungi, including Neonothopanus nambi, Omphalotus olea... | 1 | Bioluminescence |
* J.G. Nicholls, A.R. Martin, B.G. Wallace and P.A. Fuchs. "From Neuron to Brain". 4th ed. Sinauer Associates, Sunderland, MA. | 0 | Neurochemistry |
The p75 neurotrophin receptor (p75NTR) was first identified in 1973 as the low-affinity nerve growth factor receptor (LNGFR) before discovery that p75NTR bound other neurotrophins equally well as nerve growth factor. p75NTR is a neurotrophic factor receptor. Neurotrophic factor receptors bind Neurotrophins including Ne... | 0 | Neurochemistry |
Neurochemical Research is a monthly peer-reviewed scientific journal covering neurochemistry. It was established in 1976 and is published by Springer Science+Business Media. The editor-in-chief is Arne Schousboe (University of Copenhagen). | 0 | Neurochemistry |
Urinary VMA is elevated in patients with tumors that secrete catecholamines.
These urinalysis tests are used to diagnose an adrenal gland tumor called pheochromocytoma, a tumor of catecholamine-secreting chromaffin cells. These tests may also be used to diagnose neuroblastomas, and to monitor treatment of these conditi... | 0 | Neurochemistry |
Neuromelanin-containing neurons in the substantia nigra degenerate during Parkinsons disease. Motor symptoms of Parkinsons disease are caused by cell death in the substantia nigra, which may be partly due to oxidative stress. This oxidation may be relieved by neuromelanin. Patients with Parkinsons disease had 50% the a... | 0 | Neurochemistry |
Monoamine nuclei are clusters of cells that primarily use monoamine neurotransmitters to communicate. The raphe nuclei, ventral tegmental area, and locus coeruleus have been included in texts about monoamine nuclei. These nuclei receive a variety of inputs including from other monoamines, as well as from glutaminergi... | 0 | Neurochemistry |
HOCPCA (3-hydroxycyclopent-1-enecarboxylic acid) is a compound with an affinity for the GHB receptor 39 times greater than that of GHB itself. | 0 | Neurochemistry |
A different perspective on Alzheimers is revealed by a mouse study that has found that APP possesses ferroxidase activity similar to ceruloplasmin, facilitating iron export through interaction with ferroportin; it seems that this activity is blocked by zinc trapped by accumulated Aβ in Alzheimers. It has been shown th... | 0 | Neurochemistry |
There are many biologically active chemicals which elicit an effect on the nervous system. Neurotransmitters and similarly functioning biochemical messengers elicit effects on postsynaptic neurons at neuronal synapses. Excitatory Amino Acids include Glutamate, whereas inhibitory Amino Acids include GABA and Glycine. Ad... | 0 | Neurochemistry |
The mountain banshee (Ikran in Navi) is an airborne predator which lives in mountainous territory on Pandora. Navi warriors attempt to bond with a banshee, a dangerous and required rite of passage. They are cousins to the great leonopteryx and they are scientifically known by xenobiologists as Pterodactylus giganteus. ... | 1 | Bioluminescence |
Monoaminergic cell groups refers to collections of neurons in the central nervous system that have been demonstrated by histochemical fluorescence to contain one of the neurotransmitters serotonin, dopamine, norepinephrine or epinephrine. Thus, it represents the combination of catecholaminergic cell groups and serotone... | 0 | Neurochemistry |
Biophotons may be detected with photomultipliers or by means of an ultra low noise CCD camera to produce an image, using an exposure time of typically 15 minutes for plant materials. Photomultiplier tubes have been used to measure biophoton emissions from fish eggs, and some applications have measured biophotons from a... | 1 | Bioluminescence |
Through research done on nicotinic acetylcholine receptors it has been determined that the channels are activated through allosteric interactions between the binding and gating domains. Once the agonist binds it brings about conformational changes (including moving a beta sheet of the amino-terminal domain, and outwar... | 0 | Neurochemistry |
Between 1915 and 1993, 235 sightings of milky seas were documented, most of which are concentrated in the northwestern Indian Ocean near to Somalia. The luminescent glow is concentrated on the surface of the ocean and does not mix evenly throughout the water column.
In 1985, a research vessel in the Arabian Sea took wa... | 1 | Bioluminescence |
According to legend, Puerto Mosquito is named after the Mosquito, the name of one of pirate Roberto Cofresí's ships. The bio bay was proclaimed a National Natural Landmark in 1980. | 1 | Bioluminescence |
A glycinergic agent (or drug) is a chemical which functions to directly modulate the glycine system in the body or brain. Examples include glycine receptor agonists, glycine receptor antagonists, and glycine reuptake inhibitors. | 0 | Neurochemistry |
The luciferases of fireflies – of which there are over 2000 species – and of the other Elateroidea (click beetles and relatives in general) are diverse enough to be useful in molecular phylogeny. In fireflies, the oxygen required is supplied through a tube in the abdomen called the abdominal trachea. One well-studied... | 1 | Bioluminescence |
TrkB agonists have received extensive interest from the scientific community resulting in the synthesis and biological evaluation of a large number of mimetics. Deoxygedunin, with a selective TrkB activity, is able to promote axon regeneration in topical treatments. Furthermore, it shows efficacy in two Parkinsons dise... | 0 | Neurochemistry |
* Cocaine, for example, blocks the reuptake of dopamine, leaving these neurotransmitters in the synaptic gap for longer.
* AMPT prevents the conversion of tyrosine to L-DOPA, the precursor to dopamine; reserpine prevents dopamine storage within vesicles; and deprenyl inhibits monoamine oxidase (MAO)-B and thus increase... | 0 | Neurochemistry |
The final STQ-77/FET framework classifies temperament traits and their neurochemical biomarkers into 12 components: nine components regulating the formal functional aspects of behaviour (energetic, dynamic and orientational) each assessed in three domains (intellectual, physical and social-verbal); also three component... | 0 | Neurochemistry |
Firefly luciferase bioluminescence color can vary between yellow-green (λ = 550 nm) to red (λ = 620). There are currently several different mechanisms describing how the structure of luciferase affects the emission spectrum of the photon and effectively the color of light emitted.
One mechanism proposes that the color ... | 1 | Bioluminescence |
Work on aequorin began with E. Newton Harvey in 1921. Though Harvey was unable to demonstrate a classical luciferase-luciferin reaction, he showed that water could produce light from dried photocytes and that light could be produced even in the absence of oxygen. Later, Osamu Shimomura began work into the bioluminescen... | 1 | Bioluminescence |
The purpose of both the (primary) bioluminescence (from aequorins action on luciferin) and the (secondary) fluorescence of GFP in jellyfish is unknown. GFP is co-expressed with aequorin in small granules around the rim of the jellyfish bell. The secondary excitation peak (480 nm) of GFP does absorb some of the blue emi... | 1 | Bioluminescence |
Chemi-excitation via oxidative stress by reactive oxygen species or catalysis by enzymes (i.e., peroxidase, lipoxygenase) is a common event in the biomolecular milieu. Such reactions can lead to the formation of triplet excited species, which release photons upon returning to a lower energy level in a process analogous... | 1 | Bioluminescence |
In spite of the usefulness in cell tracking and cell visualization of Kaede, there are some limitations.
Although Kaede will shift to red upon the exposure of UV or violet light and display a 2,000-fold increase in red-to-green fluorescence ratio, using both the red and green fluorescence bands can cause problems in m... | 1 | Bioluminescence |
Neuromelanin is found in higher concentrations in humans than in other primates. Neuromelanin concentration increases with age, suggesting a role in neuroprotection (neuromelanin can chelate metals and xenobiotics) or senescence. | 0 | Neurochemistry |
Neurotrophins are a family of proteins that induce the survival, development, and function of neurons.
They belong to a class of growth factors, secreted proteins that can signal particular cells to survive, differentiate, or grow. Growth factors such as neurotrophins that promote the survival of neurons are known as n... | 0 | Neurochemistry |
It was discovered that bioluminescent snails are able to exercise a great deal of control over light emission, but the way in which they exercise control over it is still unknown. Phuphania have even been shown to be able to preserve their ability to produce light even after long periods of hibernation. It is currently... | 1 | Bioluminescence |
Endocannabinoids are known to influence synaptic plasticity, and are in particular thought to mediate long-term depression (LTD, which refers to neuronal firing, not psychological depression). Short-term depression (STD) has also been described (see the next paragraph). First reported in the striatum, this system is kn... | 0 | Neurochemistry |
Schizophrenia is a psychological disorder in which a patient experiences symptoms including hallucinations, delusions, amotivation, social withdrawal, cognitive defects, and poor working memory. Heredity and gene inheritance is a highly important risk factor, especially for identical twins. Schizophrenia is anatomicall... | 0 | Neurochemistry |
The direhorse (Pali in Navi ) is a bioluminescent, hexapodal, superficially equine animal. It is scientifically known as Equidirus hoplites. The Navi use the direhorse to hunt. The direhorse was conceived and designed by Cameron and Stan Winston Studios. The direhorse is grey with blue stripes and stands tall, long. ... | 1 | Bioluminescence |
* Anandamide
* 2-Arachidonoylglycerol
* 2-Arachidonyl glyceryl ether
* Oleamide
* Oleoylethanolamide
* Virodhamine
* Docosatetraenoylethanolamide
* Stearoylethanolamide
* N-Arachidonylglycine
* Arachidonoyl serotonin
* N-Arachidonoyl dopamine
* N-Acylethanolamine | 0 | Neurochemistry |
The photophysical properties of the FbFPs are determined by the chromophore itself and its chemical surrounding in the protein. The extinction coefficient (ε) is around 14.200 Mcm at 450 nm for all described FbFPs, which is slightly higher than that of free FMN (ε = 12.200 Mcm ). The Fluorescence-Quantum yield (Φ) vari... | 1 | Bioluminescence |
The uses of bioluminescence and its biological and ecological significance for animals, including host organisms for bacteria symbiosis, have been widely studied. The biological role and evolutionary history for specifically bioluminescent bacteria still remains quite mysterious and unclear. However, there are continua... | 1 | Bioluminescence |
The molecular mechanisms of CB-mediated changes to the membrane voltage have also been studied in detail. Cannabinoids reduce calcium influx by blocking the activity of voltage-dependent N-, P/Q- and L-type calcium channels. In addition to acting on calcium channels, activation of Gi/o and Gs, the two most commonly cou... | 0 | Neurochemistry |
The biggest advantage of GFP is that it can be heritable, depending on how it was introduced, allowing for continued study of cells and tissues it is expressed in. Visualizing GFP is noninvasive, requiring only illumination with blue light. GFP alone does not interfere with biological processes, but when fused to prote... | 1 | Bioluminescence |
Vagusstoff (literally translated from German as "Vagus Substance") refers to the substance released by stimulation of the vagus nerve which causes a reduction in the heart rate. Discovered in 1921 by physiologist Otto Loewi, vagusstoff was the first confirmation of chemical synaptic transmission and the first neurotra... | 0 | Neurochemistry |
Increased endocannabinoid signaling within the central nervous system promotes sleep-inducing effects. Intercerebroventricular administration of anandamide in rats has been shown to decrease wakefulness and increase slow-wave sleep and REM sleep. Administration of anandamide into the basal forebrain of rats has also be... | 0 | Neurochemistry |
BC200 RNA has been found to be a factor in numerous types of cancer. Although this type of RNA is normally expressed in neurons, it has been detected in cancers of the breast, cervix, esophagus, lungs, ovaries, parotid glands, tongue, and the colon. In certain cancers, expression of BC200 RNA is upregulated. This occur... | 0 | Neurochemistry |
Bioluminescent bacteria are light-producing bacteria that are predominantly present in sea water, marine sediments, the surface of decomposing fish and in the gut of marine animals. While not as common, bacterial bioluminescence is also found in terrestrial and freshwater bacteria. These bacteria may be free living (su... | 1 | Bioluminescence |
The first symptoms of apitoxin (bee venom), that are now thought to be caused by apamin, were described back in 1936 by Hahn and Leditschke. Apamin was first isolated by Habermann in 1965 from Apis mellifera, the Western honey bee. Apamin was named after this bee. Bee venom contains many other compounds, like histamine... | 0 | Neurochemistry |
The red chromophore, which is generated by cleavage of the peptide backbone, has an absorption maxima at 571 nm and an emission maxima at 581 nm, in its anionic form. The break in the peptide backbone that leads to this chromophore is between His-62 Nα and Cα. The observed red fluorescence occurs due to an extension of... | 1 | Bioluminescence |
In excitotoxicity, nerve cells suffer damage or death when the levels of otherwise necessary and safe neurotransmitters such as glutamate become pathologically high, resulting in excessive stimulation of receptors. For example, when glutamate receptors such as the NMDA receptor or AMPA receptor encounter excessive lev... | 0 | Neurochemistry |
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