instruction
stringlengths
34
186
input
stringlengths
2.02k
93.8k
output
stringlengths
2
418
meta_questiontype
stringclasses
6 values
meta_inputlicense
stringclasses
6 values
meta_pmid
stringlengths
8
8
meta_safetyreportid
int64
9.51M
21M
meta_articlepubdate
stringlengths
4
10
What was the outcome of reaction 'Rales'?
Unexpected acute pulmonary embolism in an old COVID-19 patient with warfarin overdose: a case report. Severe acute respiratory syndrome coronavirus 2 disease is strongly associated with a high incidence of thrombotic events. Anticoagulation could be a cornerstone in successfully managing severe forms of coronavirus dis...
Recovering
ReactionOutcome
CC BY-NC
34104863
19,494,069
2021-06
What was the outcome of reaction 'Septic shock'?
Unexpected acute pulmonary embolism in an old COVID-19 patient with warfarin overdose: a case report. Severe acute respiratory syndrome coronavirus 2 disease is strongly associated with a high incidence of thrombotic events. Anticoagulation could be a cornerstone in successfully managing severe forms of coronavirus dis...
Fatal
ReactionOutcome
CC BY-NC
34104863
19,494,069
2021-06
What was the outcome of reaction 'Traumatic lung injury'?
Unexpected acute pulmonary embolism in an old COVID-19 patient with warfarin overdose: a case report. Severe acute respiratory syndrome coronavirus 2 disease is strongly associated with a high incidence of thrombotic events. Anticoagulation could be a cornerstone in successfully managing severe forms of coronavirus dis...
Recovering
ReactionOutcome
CC BY-NC
34104863
19,495,913
2021-06
Give an alphabetized list of all active substances of drugs taken by the patient who experienced 'Congenital central nervous system anomaly'.
Exposure to alirocumab during the first trimester of pregnancy: A case report. Familial hypercholesterolemia can be efficiently treated with combined lipid-lowering drugs. Lipid-lowering drugs are usually withdrawn for pregnancy and breastfeeding, ideally preconception, followed by lipid apheresis, however, careful pla...
ALIROCUMAB, ALPRAZOLAM, ASPIRIN, EZETIMIBE, ROSUVASTATIN
DrugsGivenReaction
CC BY-NC-ND
34105316
16,356,776
2021-09-01
Give an alphabetized list of all active substances of drugs taken by the patient who experienced 'Foetal exposure during pregnancy'.
Exposure to alirocumab during the first trimester of pregnancy: A case report. Familial hypercholesterolemia can be efficiently treated with combined lipid-lowering drugs. Lipid-lowering drugs are usually withdrawn for pregnancy and breastfeeding, ideally preconception, followed by lipid apheresis, however, careful pla...
ALIROCUMAB, ALPRAZOLAM, ASPIRIN, EZETIMIBE, ROSUVASTATIN
DrugsGivenReaction
CC BY-NC-ND
34105316
16,356,776
2021-09-01
Give an alphabetized list of all active substances of drugs taken by the patient who experienced 'Normal newborn'.
Exposure to alirocumab during the first trimester of pregnancy: A case report. Familial hypercholesterolemia can be efficiently treated with combined lipid-lowering drugs. Lipid-lowering drugs are usually withdrawn for pregnancy and breastfeeding, ideally preconception, followed by lipid apheresis, however, careful pla...
ALIROCUMAB, ANHYDROUS CITRIC ACID\DEXTROSE MONOHYDRATE\SODIUM CITRATE, ASPIRIN, CALCIUM, CLOPIDOGREL BISULFATE, EZETIMIBE, HEPARIN SODIUM, ROSUVASTATIN, SODIUM CHLORIDE
DrugsGivenReaction
CC BY-NC-ND
34105316
20,871,051
2021-09-01
What is the weight of the patient?
Exposure to alirocumab during the first trimester of pregnancy: A case report. Familial hypercholesterolemia can be efficiently treated with combined lipid-lowering drugs. Lipid-lowering drugs are usually withdrawn for pregnancy and breastfeeding, ideally preconception, followed by lipid apheresis, however, careful pla...
3.22 kg.
Weight
CC BY-NC-ND
34105316
16,356,776
2021-09-01
What was the administration route of drug 'ALPRAZOLAM'?
Exposure to alirocumab during the first trimester of pregnancy: A case report. Familial hypercholesterolemia can be efficiently treated with combined lipid-lowering drugs. Lipid-lowering drugs are usually withdrawn for pregnancy and breastfeeding, ideally preconception, followed by lipid apheresis, however, careful pla...
Transplacental
DrugAdministrationRoute
CC BY-NC-ND
34105316
16,356,776
2021-09-01
What was the administration route of drug 'CLOPIDOGREL BISULFATE'?
Exposure to alirocumab during the first trimester of pregnancy: A case report. Familial hypercholesterolemia can be efficiently treated with combined lipid-lowering drugs. Lipid-lowering drugs are usually withdrawn for pregnancy and breastfeeding, ideally preconception, followed by lipid apheresis, however, careful pla...
Oral
DrugAdministrationRoute
CC BY-NC-ND
34105316
20,882,550
2021-09-01
What was the dosage of drug 'ANHYDROUS CITRIC ACID\DEXTROSE MONOHYDRATE\SODIUM CITRATE'?
Exposure to alirocumab during the first trimester of pregnancy: A case report. Familial hypercholesterolemia can be efficiently treated with combined lipid-lowering drugs. Lipid-lowering drugs are usually withdrawn for pregnancy and breastfeeding, ideally preconception, followed by lipid apheresis, however, careful pla...
275 MILLILITER, PER SESSION
DrugDosageText
CC BY-NC-ND
34105316
20,871,051
2021-09-01
What was the dosage of drug 'HEPARIN SODIUM'?
Exposure to alirocumab during the first trimester of pregnancy: A case report. Familial hypercholesterolemia can be efficiently treated with combined lipid-lowering drugs. Lipid-lowering drugs are usually withdrawn for pregnancy and breastfeeding, ideally preconception, followed by lipid apheresis, however, careful pla...
1500 INTERNATIONAL UNIT
DrugDosageText
CC BY-NC-ND
34105316
20,871,051
2021-09-01
What was the dosage of drug 'SODIUM CHLORIDE'?
Exposure to alirocumab during the first trimester of pregnancy: A case report. Familial hypercholesterolemia can be efficiently treated with combined lipid-lowering drugs. Lipid-lowering drugs are usually withdrawn for pregnancy and breastfeeding, ideally preconception, followed by lipid apheresis, however, careful pla...
UNK, INFUSION
DrugDosageText
CC BY-NC-ND
34105316
20,871,051
2021-09-01
What was the outcome of reaction 'Congenital central nervous system anomaly'?
Exposure to alirocumab during the first trimester of pregnancy: A case report. Familial hypercholesterolemia can be efficiently treated with combined lipid-lowering drugs. Lipid-lowering drugs are usually withdrawn for pregnancy and breastfeeding, ideally preconception, followed by lipid apheresis, however, careful pla...
Not recovered
ReactionOutcome
CC BY-NC-ND
34105316
16,356,776
2021-09-01
What was the outcome of reaction 'Foetal exposure during pregnancy'?
Exposure to alirocumab during the first trimester of pregnancy: A case report. Familial hypercholesterolemia can be efficiently treated with combined lipid-lowering drugs. Lipid-lowering drugs are usually withdrawn for pregnancy and breastfeeding, ideally preconception, followed by lipid apheresis, however, careful pla...
Not recovered
ReactionOutcome
CC BY-NC-ND
34105316
16,356,776
2021-09-01
Give an alphabetized list of all active substances of drugs taken by the patient who experienced 'Microcephaly'.
Association of Chemotherapy Timing in Pregnancy With Congenital Malformation. Chemotherapy during the first trimester of pregnancy should be avoided owing to the risk of congenital malformations. However, the precise gestational age at which chemotherapy can be initiated safely remains unclear. To assess congenital mal...
CYCLOPHOSPHAMIDE, DOCETAXEL, DOXORUBICIN HYDROCHLORIDE, TAMOXIFEN, TEMOZOLOMIDE
DrugsGivenReaction
CC BY
34106263
20,096,079
2021-06-01
Give an alphabetized list of all active substances of drugs taken by the patient who experienced 'Phalangeal hypoplasia'.
Association of Chemotherapy Timing in Pregnancy With Congenital Malformation. Chemotherapy during the first trimester of pregnancy should be avoided owing to the risk of congenital malformations. However, the precise gestational age at which chemotherapy can be initiated safely remains unclear. To assess congenital mal...
CYCLOPHOSPHAMIDE, DOCETAXEL, DOXORUBICIN HYDROCHLORIDE, GRANULOCYTE COLONY-STIMULATING FACTOR NOS
DrugsGivenReaction
CC BY
34106263
19,932,084
2021-06-01
Give an alphabetized list of all active substances of drugs taken by the patient who experienced 'Syndactyly'.
Association of Chemotherapy Timing in Pregnancy With Congenital Malformation. Chemotherapy during the first trimester of pregnancy should be avoided owing to the risk of congenital malformations. However, the precise gestational age at which chemotherapy can be initiated safely remains unclear. To assess congenital mal...
CYCLOPHOSPHAMIDE, DOCETAXEL, DOXORUBICIN HYDROCHLORIDE, GRANULOCYTE COLONY-STIMULATING FACTOR NOS
DrugsGivenReaction
CC BY
34106263
19,932,084
2021-06-01
What was the administration route of drug 'CYCLOPHOSPHAMIDE'?
Association of Chemotherapy Timing in Pregnancy With Congenital Malformation. Chemotherapy during the first trimester of pregnancy should be avoided owing to the risk of congenital malformations. However, the precise gestational age at which chemotherapy can be initiated safely remains unclear. To assess congenital mal...
Transplacental
DrugAdministrationRoute
CC BY
34106263
19,932,084
2021-06-01
What was the administration route of drug 'DOCETAXEL'?
Association of Chemotherapy Timing in Pregnancy With Congenital Malformation. Chemotherapy during the first trimester of pregnancy should be avoided owing to the risk of congenital malformations. However, the precise gestational age at which chemotherapy can be initiated safely remains unclear. To assess congenital mal...
Transplacental
DrugAdministrationRoute
CC BY
34106263
19,932,084
2021-06-01
What was the administration route of drug 'DOXORUBICIN HYDROCHLORIDE'?
Association of Chemotherapy Timing in Pregnancy With Congenital Malformation. Chemotherapy during the first trimester of pregnancy should be avoided owing to the risk of congenital malformations. However, the precise gestational age at which chemotherapy can be initiated safely remains unclear. To assess congenital mal...
Transplacental
DrugAdministrationRoute
CC BY
34106263
19,932,084
2021-06-01
What was the administration route of drug 'GRANULOCYTE COLONY-STIMULATING FACTOR NOS'?
Association of Chemotherapy Timing in Pregnancy With Congenital Malformation. Chemotherapy during the first trimester of pregnancy should be avoided owing to the risk of congenital malformations. However, the precise gestational age at which chemotherapy can be initiated safely remains unclear. To assess congenital mal...
Transplacental
DrugAdministrationRoute
CC BY
34106263
19,932,084
2021-06-01
What was the administration route of drug 'TAMOXIFEN'?
Association of Chemotherapy Timing in Pregnancy With Congenital Malformation. Chemotherapy during the first trimester of pregnancy should be avoided owing to the risk of congenital malformations. However, the precise gestational age at which chemotherapy can be initiated safely remains unclear. To assess congenital mal...
Transplacental
DrugAdministrationRoute
CC BY
34106263
19,911,157
2021-06-01
What was the administration route of drug 'TEMOZOLOMIDE'?
Association of Chemotherapy Timing in Pregnancy With Congenital Malformation. Chemotherapy during the first trimester of pregnancy should be avoided owing to the risk of congenital malformations. However, the precise gestational age at which chemotherapy can be initiated safely remains unclear. To assess congenital mal...
Transplacental
DrugAdministrationRoute
CC BY
34106263
20,096,079
2021-06-01
What was the outcome of reaction 'Foetal exposure during pregnancy'?
Association of Chemotherapy Timing in Pregnancy With Congenital Malformation. Chemotherapy during the first trimester of pregnancy should be avoided owing to the risk of congenital malformations. However, the precise gestational age at which chemotherapy can be initiated safely remains unclear. To assess congenital mal...
Recovered
ReactionOutcome
CC BY
34106263
19,932,084
2021-06-01
Give an alphabetized list of all active substances of drugs taken by the patient who experienced 'Condition aggravated'.
Using JAK inhibitor to treat cytokine release syndrome developed after chimeric antigen receptor T cell therapy for patients with refractory acute lymphoblastic leukemia: A case report. BACKGROUND Significant concerns about the adverse effects following chimeric antigen receptor T cell (CAR-T) therapy are still remaine...
METHYLPREDNISOLONE, RUXOLITINIB, TOCILIZUMAB
DrugsGivenReaction
CC BY
34106613
19,461,437
2021-05-14
Give an alphabetized list of all active substances of drugs taken by the patient who experienced 'Cytokine release syndrome'.
Using JAK inhibitor to treat cytokine release syndrome developed after chimeric antigen receptor T cell therapy for patients with refractory acute lymphoblastic leukemia: A case report. BACKGROUND Significant concerns about the adverse effects following chimeric antigen receptor T cell (CAR-T) therapy are still remaine...
METHYLPREDNISOLONE, RUXOLITINIB, TOCILIZUMAB
DrugsGivenReaction
CC BY
34106613
19,461,437
2021-05-14
Give an alphabetized list of all active substances of drugs taken by the patient who experienced 'Product use in unapproved indication'.
Using JAK inhibitor to treat cytokine release syndrome developed after chimeric antigen receptor T cell therapy for patients with refractory acute lymphoblastic leukemia: A case report. BACKGROUND Significant concerns about the adverse effects following chimeric antigen receptor T cell (CAR-T) therapy are still remaine...
METHYLPREDNISOLONE, RUXOLITINIB, TOCILIZUMAB
DrugsGivenReaction
CC BY
34106613
19,461,437
2021-05-14
What was the dosage of drug 'METHYLPREDNISOLONE'?
Using JAK inhibitor to treat cytokine release syndrome developed after chimeric antigen receptor T cell therapy for patients with refractory acute lymphoblastic leukemia: A case report. BACKGROUND Significant concerns about the adverse effects following chimeric antigen receptor T cell (CAR-T) therapy are still remaine...
40 mg (milligrams).
DrugDosage
CC BY
34106613
19,461,437
2021-05-14
What was the dosage of drug 'TOCILIZUMAB'?
Using JAK inhibitor to treat cytokine release syndrome developed after chimeric antigen receptor T cell therapy for patients with refractory acute lymphoblastic leukemia: A case report. BACKGROUND Significant concerns about the adverse effects following chimeric antigen receptor T cell (CAR-T) therapy are still remaine...
400 mg (milligrams).
DrugDosage
CC BY
34106613
19,461,437
2021-05-14
What was the outcome of reaction 'Cytokine release syndrome'?
Using JAK inhibitor to treat cytokine release syndrome developed after chimeric antigen receptor T cell therapy for patients with refractory acute lymphoblastic leukemia: A case report. BACKGROUND Significant concerns about the adverse effects following chimeric antigen receptor T cell (CAR-T) therapy are still remaine...
Recovered
ReactionOutcome
CC BY
34106613
19,461,437
2021-05-14
What was the administration route of drug 'PROPOFOL'?
Successful diagnosis and treatment of pulmonary aspergillosis-related malignant catatonia using propofol and quetiapine: A case report. BACKGROUND Malignant catatonia (MC) is a movement disorder syndrome characterized by immobility, rigidity, and consciousness disorders that develops in association with mental and phys...
Intravenous (not otherwise specified)
DrugAdministrationRoute
CC BY
34106671
20,650,854
2021-05-14
Give an alphabetized list of all active substances of drugs taken by the patient who experienced 'Drug ineffective'.
Spontaneous perirenal hemorrhage in systemic lupus erythematosus: a rare case report and literature review. Spontaneous perirenal hemorrhage is relatively uncommon but may be life-threatening. There are some challenges in early diagnosis due to the lack of specific presentations. We report a case of spontaneous peri...
CYCLOPHOSPHAMIDE, CYCLOSPORINE, HEPARIN SODIUM, METHYLPREDNISOLONE
DrugsGivenReaction
CC BY
34107924
20,481,432
2021-06-09
Give an alphabetized list of all active substances of drugs taken by the patient who experienced 'Product use in unapproved indication'.
Spontaneous perirenal hemorrhage in systemic lupus erythematosus: a rare case report and literature review. Spontaneous perirenal hemorrhage is relatively uncommon but may be life-threatening. There are some challenges in early diagnosis due to the lack of specific presentations. We report a case of spontaneous peri...
CYCLOPHOSPHAMIDE, CYCLOSPORINE, HEPARIN SODIUM, METHYLPREDNISOLONE
DrugsGivenReaction
CC BY
34107924
20,481,432
2021-06-09
Give an alphabetized list of all active substances of drugs taken by the patient who experienced 'Renal haemorrhage'.
Spontaneous perirenal hemorrhage in systemic lupus erythematosus: a rare case report and literature review. Spontaneous perirenal hemorrhage is relatively uncommon but may be life-threatening. There are some challenges in early diagnosis due to the lack of specific presentations. We report a case of spontaneous peri...
CYCLOPHOSPHAMIDE, CYCLOSPORINE, HEPARIN SODIUM, METHYLPREDNISOLONE
DrugsGivenReaction
CC BY
34107924
20,481,432
2021-06-09
What was the administration route of drug 'CYCLOPHOSPHAMIDE'?
Spontaneous perirenal hemorrhage in systemic lupus erythematosus: a rare case report and literature review. Spontaneous perirenal hemorrhage is relatively uncommon but may be life-threatening. There are some challenges in early diagnosis due to the lack of specific presentations. We report a case of spontaneous peri...
Intravenous bolus
DrugAdministrationRoute
CC BY
34107924
20,481,432
2021-06-09
What was the administration route of drug 'METHYLPREDNISOLONE'?
Spontaneous perirenal hemorrhage in systemic lupus erythematosus: a rare case report and literature review. Spontaneous perirenal hemorrhage is relatively uncommon but may be life-threatening. There are some challenges in early diagnosis due to the lack of specific presentations. We report a case of spontaneous peri...
Intravenous (not otherwise specified)
DrugAdministrationRoute
CC BY
34107924
20,481,432
2021-06-09
What was the dosage of drug 'CYCLOPHOSPHAMIDE'?
Spontaneous perirenal hemorrhage in systemic lupus erythematosus: a rare case report and literature review. Spontaneous perirenal hemorrhage is relatively uncommon but may be life-threatening. There are some challenges in early diagnosis due to the lack of specific presentations. We report a case of spontaneous peri...
TWO BOLUSES
DrugDosageText
CC BY
34107924
20,481,432
2021-06-09
What was the dosage of drug 'CYCLOSPORINE'?
Spontaneous perirenal hemorrhage in systemic lupus erythematosus: a rare case report and literature review. Spontaneous perirenal hemorrhage is relatively uncommon but may be life-threatening. There are some challenges in early diagnosis due to the lack of specific presentations. We report a case of spontaneous peri...
50 mg (milligrams).
DrugDosage
CC BY
34107924
20,481,432
2021-06-09
What was the outcome of reaction 'Renal haemorrhage'?
Spontaneous perirenal hemorrhage in systemic lupus erythematosus: a rare case report and literature review. Spontaneous perirenal hemorrhage is relatively uncommon but may be life-threatening. There are some challenges in early diagnosis due to the lack of specific presentations. We report a case of spontaneous peri...
Recovered
ReactionOutcome
CC BY
34107924
20,481,432
2021-06-09
Give an alphabetized list of all active substances of drugs taken by the patient who experienced 'Condition aggravated'.
A case of tamoxifen-induced hypertriglyceridemia monitoring the changes in lipoprotein fractions over time. BACKGROUND Tamoxifen, which is one of the selective estrogen receptor modulators (SERMs), can bring out life-threatening complication, e.g. hypertriglyceridemia-induced acute pancreatitis, although it is rare. We...
DULAGLUTIDE, FENOFIBRATE, GLIMEPIRIDE, ROSUVASTATIN, TAMOXIFEN, TOCOPHERYL NICOTINATE, D-.ALPHA.
DrugsGivenReaction
CC BY
34107939
19,570,772
2021-06-09
Give an alphabetized list of all active substances of drugs taken by the patient who experienced 'Dehydration'.
A case of tamoxifen-induced hypertriglyceridemia monitoring the changes in lipoprotein fractions over time. BACKGROUND Tamoxifen, which is one of the selective estrogen receptor modulators (SERMs), can bring out life-threatening complication, e.g. hypertriglyceridemia-induced acute pancreatitis, although it is rare. We...
ROSUVASTATIN, TAMOXIFEN, TOCOPHEROL
DrugsGivenReaction
CC BY
34107939
19,497,251
2021-06-09
Give an alphabetized list of all active substances of drugs taken by the patient who experienced 'Pancreatitis acute'.
A case of tamoxifen-induced hypertriglyceridemia monitoring the changes in lipoprotein fractions over time. BACKGROUND Tamoxifen, which is one of the selective estrogen receptor modulators (SERMs), can bring out life-threatening complication, e.g. hypertriglyceridemia-induced acute pancreatitis, although it is rare. We...
DULAGLUTIDE, FENOFIBRATE, GLIMEPIRIDE, ROSUVASTATIN, TAMOXIFEN, TOCOPHERYL NICOTINATE, D-.ALPHA.
DrugsGivenReaction
CC BY
34107939
19,570,772
2021-06-09
What is the weight of the patient?
A case of tamoxifen-induced hypertriglyceridemia monitoring the changes in lipoprotein fractions over time. BACKGROUND Tamoxifen, which is one of the selective estrogen receptor modulators (SERMs), can bring out life-threatening complication, e.g. hypertriglyceridemia-induced acute pancreatitis, although it is rare. We...
52 kg.
Weight
CC BY
34107939
19,500,377
2021-06-09
What was the administration route of drug 'ROSUVASTATIN CALCIUM'?
A case of tamoxifen-induced hypertriglyceridemia monitoring the changes in lipoprotein fractions over time. BACKGROUND Tamoxifen, which is one of the selective estrogen receptor modulators (SERMs), can bring out life-threatening complication, e.g. hypertriglyceridemia-induced acute pancreatitis, although it is rare. We...
Oral
DrugAdministrationRoute
CC BY
34107939
19,500,377
2021-06-09
What was the administration route of drug 'TAMOXIFEN CITRATE'?
A case of tamoxifen-induced hypertriglyceridemia monitoring the changes in lipoprotein fractions over time. BACKGROUND Tamoxifen, which is one of the selective estrogen receptor modulators (SERMs), can bring out life-threatening complication, e.g. hypertriglyceridemia-induced acute pancreatitis, although it is rare. We...
Oral
DrugAdministrationRoute
CC BY
34107939
19,500,377
2021-06-09
What was the administration route of drug 'TOCOPHERYL NICOTINATE, D-.ALPHA.'?
A case of tamoxifen-induced hypertriglyceridemia monitoring the changes in lipoprotein fractions over time. BACKGROUND Tamoxifen, which is one of the selective estrogen receptor modulators (SERMs), can bring out life-threatening complication, e.g. hypertriglyceridemia-induced acute pancreatitis, although it is rare. We...
Oral
DrugAdministrationRoute
CC BY
34107939
19,500,377
2021-06-09
What was the dosage of drug 'FENOFIBRATE'?
A case of tamoxifen-induced hypertriglyceridemia monitoring the changes in lipoprotein fractions over time. BACKGROUND Tamoxifen, which is one of the selective estrogen receptor modulators (SERMs), can bring out life-threatening complication, e.g. hypertriglyceridemia-induced acute pancreatitis, although it is rare. We...
80 mg (milligrams).
DrugDosage
CC BY
34107939
19,570,772
2021-06-09
What was the dosage of drug 'INSULIN NOS'?
A case of tamoxifen-induced hypertriglyceridemia monitoring the changes in lipoprotein fractions over time. BACKGROUND Tamoxifen, which is one of the selective estrogen receptor modulators (SERMs), can bring out life-threatening complication, e.g. hypertriglyceridemia-induced acute pancreatitis, although it is rare. We...
DOSE UNKNOWN
DrugDosageText
CC BY
34107939
19,500,377
2021-06-09
What was the dosage of drug 'ROSUVASTATIN'?
A case of tamoxifen-induced hypertriglyceridemia monitoring the changes in lipoprotein fractions over time. BACKGROUND Tamoxifen, which is one of the selective estrogen receptor modulators (SERMs), can bring out life-threatening complication, e.g. hypertriglyceridemia-induced acute pancreatitis, although it is rare. We...
2.5 mg (milligrams).
DrugDosage
CC BY
34107939
19,570,772
2021-06-09
What was the dosage of drug 'TAMOXIFEN CITRATE'?
A case of tamoxifen-induced hypertriglyceridemia monitoring the changes in lipoprotein fractions over time. BACKGROUND Tamoxifen, which is one of the selective estrogen receptor modulators (SERMs), can bring out life-threatening complication, e.g. hypertriglyceridemia-induced acute pancreatitis, although it is rare. We...
DOSE UNKNOWN
DrugDosageText
CC BY
34107939
19,500,377
2021-06-09
What was the dosage of drug 'TOCOPHEROL'?
A case of tamoxifen-induced hypertriglyceridemia monitoring the changes in lipoprotein fractions over time. BACKGROUND Tamoxifen, which is one of the selective estrogen receptor modulators (SERMs), can bring out life-threatening complication, e.g. hypertriglyceridemia-induced acute pancreatitis, although it is rare. We...
400 mg (milligrams).
DrugDosage
CC BY
34107939
19,497,251
2021-06-09
What was the outcome of reaction 'Condition aggravated'?
A case of tamoxifen-induced hypertriglyceridemia monitoring the changes in lipoprotein fractions over time. BACKGROUND Tamoxifen, which is one of the selective estrogen receptor modulators (SERMs), can bring out life-threatening complication, e.g. hypertriglyceridemia-induced acute pancreatitis, although it is rare. We...
Recovering
ReactionOutcome
CC BY
34107939
19,570,772
2021-06-09
What was the outcome of reaction 'Dehydration'?
A case of tamoxifen-induced hypertriglyceridemia monitoring the changes in lipoprotein fractions over time. BACKGROUND Tamoxifen, which is one of the selective estrogen receptor modulators (SERMs), can bring out life-threatening complication, e.g. hypertriglyceridemia-induced acute pancreatitis, although it is rare. We...
Recovering
ReactionOutcome
CC BY
34107939
19,497,251
2021-06-09
What was the outcome of reaction 'Hypertriglyceridaemia'?
A case of tamoxifen-induced hypertriglyceridemia monitoring the changes in lipoprotein fractions over time. BACKGROUND Tamoxifen, which is one of the selective estrogen receptor modulators (SERMs), can bring out life-threatening complication, e.g. hypertriglyceridemia-induced acute pancreatitis, although it is rare. We...
Recovering
ReactionOutcome
CC BY
34107939
19,500,377
2021-06-09
What was the outcome of reaction 'Pancreatitis acute'?
A case of tamoxifen-induced hypertriglyceridemia monitoring the changes in lipoprotein fractions over time. BACKGROUND Tamoxifen, which is one of the selective estrogen receptor modulators (SERMs), can bring out life-threatening complication, e.g. hypertriglyceridemia-induced acute pancreatitis, although it is rare. We...
Recovering
ReactionOutcome
CC BY
34107939
19,570,772
2021-06-09
What was the outcome of reaction 'Renal impairment'?
A case of tamoxifen-induced hypertriglyceridemia monitoring the changes in lipoprotein fractions over time. BACKGROUND Tamoxifen, which is one of the selective estrogen receptor modulators (SERMs), can bring out life-threatening complication, e.g. hypertriglyceridemia-induced acute pancreatitis, although it is rare. We...
Recovering
ReactionOutcome
CC BY
34107939
19,500,377
2021-06-09
Give an alphabetized list of all active substances of drugs taken by the patient who experienced 'Disease progression'.
Case Report: Anlotinib Combined With Sintilimab as Third-Line Treatment in a Metastatic Urothelial Bladder Carcinoma Patient With FGFR3 Mutation. We report on a case of metastatic urothelial bladder carcinoma (mUBC) treated with anlotinib combined with sintilimab. A 69-year-old male was diagnosed with non-muscle invasi...
CISPLATIN, GEMCITABINE
DrugsGivenReaction
CC BY
34109111
20,557,200
2021
What was the administration route of drug 'GEMCITABINE'?
Case Report: Anlotinib Combined With Sintilimab as Third-Line Treatment in a Metastatic Urothelial Bladder Carcinoma Patient With FGFR3 Mutation. We report on a case of metastatic urothelial bladder carcinoma (mUBC) treated with anlotinib combined with sintilimab. A 69-year-old male was diagnosed with non-muscle invasi...
Intravesical
DrugAdministrationRoute
CC BY
34109111
20,557,200
2021
What was the dosage of drug 'CISPLATIN'?
Case Report: Anlotinib Combined With Sintilimab as Third-Line Treatment in a Metastatic Urothelial Bladder Carcinoma Patient With FGFR3 Mutation. We report on a case of metastatic urothelial bladder carcinoma (mUBC) treated with anlotinib combined with sintilimab. A 69-year-old male was diagnosed with non-muscle invasi...
4 CYCLES
DrugDosageText
CC BY
34109111
20,557,200
2021
What was the dosage of drug 'GEMCITABINE'?
Case Report: Anlotinib Combined With Sintilimab as Third-Line Treatment in a Metastatic Urothelial Bladder Carcinoma Patient With FGFR3 Mutation. We report on a case of metastatic urothelial bladder carcinoma (mUBC) treated with anlotinib combined with sintilimab. A 69-year-old male was diagnosed with non-muscle invasi...
SINGLE-DOSE 4 CYCLES
DrugDosageText
CC BY
34109111
20,557,200
2021
Give an alphabetized list of all active substances of drugs taken by the patient who experienced 'Therapeutic product effect incomplete'.
Gastric Adenocarcinoma Presenting as a Rheumatoid Factor and Anti-cyclic Citrullinated Protein Antibody-Positive Polyarthritis: A Case Report and Review of Literature. A 64-year-old male presented with a 6-month history of symmetric polyarthritis involving proximal interphalangeal joints and metacarpophalangeal joints ...
ACETAMINOPHEN, CISPLATIN, FLUOROURACIL, HYDROXYCHLOROQUINE, PREDNISOLONE, TRAMADOL, TRASTUZUMAB
DrugsGivenReaction
CC BY
34109188
20,127,473
2021
What was the outcome of reaction 'Adenocarcinoma gastric'?
Gastric Adenocarcinoma Presenting as a Rheumatoid Factor and Anti-cyclic Citrullinated Protein Antibody-Positive Polyarthritis: A Case Report and Review of Literature. A 64-year-old male presented with a 6-month history of symmetric polyarthritis involving proximal interphalangeal joints and metacarpophalangeal joints ...
Fatal
ReactionOutcome
CC BY
34109188
20,017,142
2021
What was the outcome of reaction 'Death'?
Gastric Adenocarcinoma Presenting as a Rheumatoid Factor and Anti-cyclic Citrullinated Protein Antibody-Positive Polyarthritis: A Case Report and Review of Literature. A 64-year-old male presented with a 6-month history of symmetric polyarthritis involving proximal interphalangeal joints and metacarpophalangeal joints ...
Fatal
ReactionOutcome
CC BY
34109188
20,017,142
2021
Give an alphabetized list of all active substances of drugs taken by the patient who experienced 'Drug ineffective'.
Pulmonary arterial hypertension unveils itself: a cancer-like progression - a case report. Pulmonary arterial hypertension (PAH) is a rare disorder with a poor prognosis, characterized by progressive remodelling of the small pulmonary arteries that precede the clinical and haemodynamic manifestations of the disease. Th...
AMOXICILLIN\CLAVULANIC ACID, OSELTAMIVIR
DrugsGivenReaction
CC BY-NC
34109292
20,205,806
2021-05
Give an alphabetized list of all active substances of drugs taken by the patient who experienced 'Exposure during pregnancy'.
Pulmonary arterial hypertension unveils itself: a cancer-like progression - a case report. Pulmonary arterial hypertension (PAH) is a rare disorder with a poor prognosis, characterized by progressive remodelling of the small pulmonary arteries that precede the clinical and haemodynamic manifestations of the disease. Th...
AMOXICILLIN\CLAVULANIC ACID, OSELTAMIVIR
DrugsGivenReaction
CC BY-NC
34109292
20,205,806
2021-05
What was the administration route of drug 'AMOXICILLIN\CLAVULANATE POTASSIUM'?
Pulmonary arterial hypertension unveils itself: a cancer-like progression - a case report. Pulmonary arterial hypertension (PAH) is a rare disorder with a poor prognosis, characterized by progressive remodelling of the small pulmonary arteries that precede the clinical and haemodynamic manifestations of the disease. Th...
Transplacental
DrugAdministrationRoute
CC BY-NC
34109292
20,269,599
2021-05
What was the administration route of drug 'AMOXICILLIN\CLAVULANIC ACID'?
Pulmonary arterial hypertension unveils itself: a cancer-like progression - a case report. Pulmonary arterial hypertension (PAH) is a rare disorder with a poor prognosis, characterized by progressive remodelling of the small pulmonary arteries that precede the clinical and haemodynamic manifestations of the disease. Th...
Transplacental
DrugAdministrationRoute
CC BY-NC
34109292
20,161,942
2021-05
What was the administration route of drug 'BOSENTAN'?
Pulmonary arterial hypertension unveils itself: a cancer-like progression - a case report. Pulmonary arterial hypertension (PAH) is a rare disorder with a poor prognosis, characterized by progressive remodelling of the small pulmonary arteries that precede the clinical and haemodynamic manifestations of the disease. Th...
Oral
DrugAdministrationRoute
CC BY-NC
34109292
20,074,085
2021-05
What was the administration route of drug 'OSELTAMIVIR'?
Pulmonary arterial hypertension unveils itself: a cancer-like progression - a case report. Pulmonary arterial hypertension (PAH) is a rare disorder with a poor prognosis, characterized by progressive remodelling of the small pulmonary arteries that precede the clinical and haemodynamic manifestations of the disease. Th...
Transplacental
DrugAdministrationRoute
CC BY-NC
34109292
20,269,599
2021-05
What was the administration route of drug 'SELEXIPAG'?
Pulmonary arterial hypertension unveils itself: a cancer-like progression - a case report. Pulmonary arterial hypertension (PAH) is a rare disorder with a poor prognosis, characterized by progressive remodelling of the small pulmonary arteries that precede the clinical and haemodynamic manifestations of the disease. Th...
Oral
DrugAdministrationRoute
CC BY-NC
34109292
20,074,085
2021-05
What was the dosage of drug 'AMOXICILLIN\CLAVULANIC ACID'?
Pulmonary arterial hypertension unveils itself: a cancer-like progression - a case report. Pulmonary arterial hypertension (PAH) is a rare disorder with a poor prognosis, characterized by progressive remodelling of the small pulmonary arteries that precede the clinical and haemodynamic manifestations of the disease. Th...
MATERNAL DOSE: UNK (STARTED IN FEB 2018)
DrugDosageText
CC BY-NC
34109292
20,161,942
2021-05
What was the dosage of drug 'OSELTAMIVIR'?
Pulmonary arterial hypertension unveils itself: a cancer-like progression - a case report. Pulmonary arterial hypertension (PAH) is a rare disorder with a poor prognosis, characterized by progressive remodelling of the small pulmonary arteries that precede the clinical and haemodynamic manifestations of the disease. Th...
MATERNAL DOSE: UNK (STARTED IN FEB 2018)
DrugDosageText
CC BY-NC
34109292
20,161,942
2021-05
What was the outcome of reaction 'Maternal exposure during pregnancy'?
Pulmonary arterial hypertension unveils itself: a cancer-like progression - a case report. Pulmonary arterial hypertension (PAH) is a rare disorder with a poor prognosis, characterized by progressive remodelling of the small pulmonary arteries that precede the clinical and haemodynamic manifestations of the disease. Th...
Recovered
ReactionOutcome
CC BY-NC
34109292
20,074,085
2021-05
What was the outcome of reaction 'Premature delivery'?
Pulmonary arterial hypertension unveils itself: a cancer-like progression - a case report. Pulmonary arterial hypertension (PAH) is a rare disorder with a poor prognosis, characterized by progressive remodelling of the small pulmonary arteries that precede the clinical and haemodynamic manifestations of the disease. Th...
Recovered
ReactionOutcome
CC BY-NC
34109292
20,074,085
2021-05
What was the outcome of reaction 'Pulmonary arterial hypertension'?
Pulmonary arterial hypertension unveils itself: a cancer-like progression - a case report. Pulmonary arterial hypertension (PAH) is a rare disorder with a poor prognosis, characterized by progressive remodelling of the small pulmonary arteries that precede the clinical and haemodynamic manifestations of the disease. Th...
Recovering
ReactionOutcome
CC BY-NC
34109292
19,740,929
2021-05
Give an alphabetized list of all active substances of drugs taken by the patient who experienced 'Condition aggravated'.
Refractory hypercalcaemia associated with disseminated Cryptococcus neoformans infection. Hypercalcaemia is a very common endocrine condition, yet severe hypercalcaemia as a result of fungal infection is rarely described. There are have only been two reported cases in the literature of hypercalcaemia associated with Cr...
PAMIDRONATE DISODIUM
DrugsGivenReaction
CC BY-NC-ND
34110303
19,885,031
2021-06-01
Give an alphabetized list of all active substances of drugs taken by the patient who experienced 'Drug ineffective'.
Refractory hypercalcaemia associated with disseminated Cryptococcus neoformans infection. Hypercalcaemia is a very common endocrine condition, yet severe hypercalcaemia as a result of fungal infection is rarely described. There are have only been two reported cases in the literature of hypercalcaemia associated with Cr...
AMPHOTERICIN B, ASPIRIN, CHOLECALCIFEROL, CYCLOSPORINE, ENTECAVIR, FLUCONAZOLE, FLUCYTOSINE, INSULIN NOS, MYCOPHENOLATE MOFETIL, PAMIDRONATE DISODIUM, PREGABALIN, VALGANCICLOVIR
DrugsGivenReaction
CC BY-NC-ND
34110303
19,867,425
2021-06-01
What was the administration route of drug 'AMPHOTERICIN B'?
Refractory hypercalcaemia associated with disseminated Cryptococcus neoformans infection. Hypercalcaemia is a very common endocrine condition, yet severe hypercalcaemia as a result of fungal infection is rarely described. There are have only been two reported cases in the literature of hypercalcaemia associated with Cr...
Intravenous (not otherwise specified)
DrugAdministrationRoute
CC BY-NC-ND
34110303
19,867,425
2021-06-01
What was the administration route of drug 'FLUCONAZOLE'?
Refractory hypercalcaemia associated with disseminated Cryptococcus neoformans infection. Hypercalcaemia is a very common endocrine condition, yet severe hypercalcaemia as a result of fungal infection is rarely described. There are have only been two reported cases in the literature of hypercalcaemia associated with Cr...
Oral
DrugAdministrationRoute
CC BY-NC-ND
34110303
19,867,425
2021-06-01
What was the administration route of drug 'FLUCYTOSINE'?
Refractory hypercalcaemia associated with disseminated Cryptococcus neoformans infection. Hypercalcaemia is a very common endocrine condition, yet severe hypercalcaemia as a result of fungal infection is rarely described. There are have only been two reported cases in the literature of hypercalcaemia associated with Cr...
Oral
DrugAdministrationRoute
CC BY-NC-ND
34110303
19,867,425
2021-06-01
What was the administration route of drug 'PAMIDRONATE DISODIUM'?
Refractory hypercalcaemia associated with disseminated Cryptococcus neoformans infection. Hypercalcaemia is a very common endocrine condition, yet severe hypercalcaemia as a result of fungal infection is rarely described. There are have only been two reported cases in the literature of hypercalcaemia associated with Cr...
Intravenous (not otherwise specified)
DrugAdministrationRoute
CC BY-NC-ND
34110303
19,867,425
2021-06-01
What was the dosage of drug 'MYCOPHENOLIC ACID'?
Refractory hypercalcaemia associated with disseminated Cryptococcus neoformans infection. Hypercalcaemia is a very common endocrine condition, yet severe hypercalcaemia as a result of fungal infection is rarely described. There are have only been two reported cases in the literature of hypercalcaemia associated with Cr...
1000 MG
DrugDosageText
CC BY-NC-ND
34110303
20,213,806
2021-06-01
What was the outcome of reaction 'Cryptococcosis'?
Refractory hypercalcaemia associated with disseminated Cryptococcus neoformans infection. Hypercalcaemia is a very common endocrine condition, yet severe hypercalcaemia as a result of fungal infection is rarely described. There are have only been two reported cases in the literature of hypercalcaemia associated with Cr...
Not recovered
ReactionOutcome
CC BY-NC-ND
34110303
20,213,806
2021-06-01
What was the outcome of reaction 'Disseminated cryptococcosis'?
Refractory hypercalcaemia associated with disseminated Cryptococcus neoformans infection. Hypercalcaemia is a very common endocrine condition, yet severe hypercalcaemia as a result of fungal infection is rarely described. There are have only been two reported cases in the literature of hypercalcaemia associated with Cr...
Not recovered
ReactionOutcome
CC BY-NC-ND
34110303
20,213,806
2021-06-01
What was the outcome of reaction 'Hypercalcaemia'?
Refractory hypercalcaemia associated with disseminated Cryptococcus neoformans infection. Hypercalcaemia is a very common endocrine condition, yet severe hypercalcaemia as a result of fungal infection is rarely described. There are have only been two reported cases in the literature of hypercalcaemia associated with Cr...
Recovered
ReactionOutcome
CC BY-NC-ND
34110303
20,213,806
2021-06-01
Give an alphabetized list of all active substances of drugs taken by the patient who experienced 'Cataract'.
Economic burden of age-related macular degeneration in routine clinical practice: the RAMDEBURS study. OBJECTIVE To describe and evaluate the main direct health costs, in routine clinical practice, of age-related macular degeneration (AMD) patients, from hospital perspective, in Spain. METHODS Retrospective, multicen...
AFLIBERCEPT, BEVACIZUMAB, RANIBIZUMAB
DrugsGivenReaction
CC BY
34110547
19,949,957
2021-10
Give an alphabetized list of all active substances of drugs taken by the patient who experienced 'Endophthalmitis'.
Economic burden of age-related macular degeneration in routine clinical practice: the RAMDEBURS study. OBJECTIVE To describe and evaluate the main direct health costs, in routine clinical practice, of age-related macular degeneration (AMD) patients, from hospital perspective, in Spain. METHODS Retrospective, multicen...
AFLIBERCEPT, BEVACIZUMAB, RANIBIZUMAB
DrugsGivenReaction
CC BY
34110547
19,949,957
2021-10
Give an alphabetized list of all active substances of drugs taken by the patient who experienced 'Intraocular pressure increased'.
Economic burden of age-related macular degeneration in routine clinical practice: the RAMDEBURS study. OBJECTIVE To describe and evaluate the main direct health costs, in routine clinical practice, of age-related macular degeneration (AMD) patients, from hospital perspective, in Spain. METHODS Retrospective, multicen...
AFLIBERCEPT, BEVACIZUMAB, RANIBIZUMAB
DrugsGivenReaction
CC BY
34110547
19,949,957
2021-10
Give an alphabetized list of all active substances of drugs taken by the patient who experienced 'Off label use'.
Economic burden of age-related macular degeneration in routine clinical practice: the RAMDEBURS study. OBJECTIVE To describe and evaluate the main direct health costs, in routine clinical practice, of age-related macular degeneration (AMD) patients, from hospital perspective, in Spain. METHODS Retrospective, multicen...
AFLIBERCEPT, BEVACIZUMAB, RANIBIZUMAB
DrugsGivenReaction
CC BY
34110547
19,949,957
2021-10
Give an alphabetized list of all active substances of drugs taken by the patient who experienced 'Retinal detachment'.
Economic burden of age-related macular degeneration in routine clinical practice: the RAMDEBURS study. OBJECTIVE To describe and evaluate the main direct health costs, in routine clinical practice, of age-related macular degeneration (AMD) patients, from hospital perspective, in Spain. METHODS Retrospective, multicen...
AFLIBERCEPT, BEVACIZUMAB, RANIBIZUMAB
DrugsGivenReaction
CC BY
34110547
19,949,957
2021-10
What was the administration route of drug 'AFLIBERCEPT'?
Economic burden of age-related macular degeneration in routine clinical practice: the RAMDEBURS study. OBJECTIVE To describe and evaluate the main direct health costs, in routine clinical practice, of age-related macular degeneration (AMD) patients, from hospital perspective, in Spain. METHODS Retrospective, multicen...
Other
DrugAdministrationRoute
CC BY
34110547
19,949,957
2021-10
What was the administration route of drug 'BEVACIZUMAB'?
Economic burden of age-related macular degeneration in routine clinical practice: the RAMDEBURS study. OBJECTIVE To describe and evaluate the main direct health costs, in routine clinical practice, of age-related macular degeneration (AMD) patients, from hospital perspective, in Spain. METHODS Retrospective, multicen...
Other
DrugAdministrationRoute
CC BY
34110547
19,949,957
2021-10
What was the administration route of drug 'RANIBIZUMAB'?
Economic burden of age-related macular degeneration in routine clinical practice: the RAMDEBURS study. OBJECTIVE To describe and evaluate the main direct health costs, in routine clinical practice, of age-related macular degeneration (AMD) patients, from hospital perspective, in Spain. METHODS Retrospective, multicen...
Other
DrugAdministrationRoute
CC BY
34110547
19,949,957
2021-10
Give an alphabetized list of all active substances of drugs taken by the patient who experienced 'Coagulopathy'.
Outcome of L-DEP regimen for treatment of pediatric chronic active Epstein-Barr virus infection. We intended to investigate the clinical features of paediatric patients with chronic active Epstein-Barr virus infection (CAEBV) and to examine the effectiveness of the L-DEP regimen before haematopoietic stem cell transpla...
DOXORUBICIN HYDROCHLORIDE, ETOPOSIDE, METHYLPREDNISOLONE, PEGASPARGASE
DrugsGivenReaction
CC BY
34112210
19,533,507
2021-06-10
Give an alphabetized list of all active substances of drugs taken by the patient who experienced 'Gastrointestinal haemorrhage'.
Outcome of L-DEP regimen for treatment of pediatric chronic active Epstein-Barr virus infection. We intended to investigate the clinical features of paediatric patients with chronic active Epstein-Barr virus infection (CAEBV) and to examine the effectiveness of the L-DEP regimen before haematopoietic stem cell transpla...
DOXORUBICIN HYDROCHLORIDE, ETOPOSIDE, METHYLPREDNISOLONE, PEGASPARGASE
DrugsGivenReaction
CC BY
34112210
19,533,507
2021-06-10
Give an alphabetized list of all active substances of drugs taken by the patient who experienced 'Hepatic failure'.
Outcome of L-DEP regimen for treatment of pediatric chronic active Epstein-Barr virus infection. We intended to investigate the clinical features of paediatric patients with chronic active Epstein-Barr virus infection (CAEBV) and to examine the effectiveness of the L-DEP regimen before haematopoietic stem cell transpla...
DOXORUBICIN HYDROCHLORIDE, ETOPOSIDE, METHYLPREDNISOLONE, PEGASPARGASE
DrugsGivenReaction
CC BY
34112210
19,533,507
2021-06-10
Give an alphabetized list of all active substances of drugs taken by the patient who experienced 'Myelosuppression'.
Outcome of L-DEP regimen for treatment of pediatric chronic active Epstein-Barr virus infection. We intended to investigate the clinical features of paediatric patients with chronic active Epstein-Barr virus infection (CAEBV) and to examine the effectiveness of the L-DEP regimen before haematopoietic stem cell transpla...
DOXORUBICIN HYDROCHLORIDE, ETOPOSIDE, METHYLPREDNISOLONE, PEGASPARGASE
DrugsGivenReaction
CC BY
34112210
19,533,510
2021-06-10
What was the dosage of drug 'DOXORUBICIN HYDROCHLORIDE'?
Outcome of L-DEP regimen for treatment of pediatric chronic active Epstein-Barr virus infection. We intended to investigate the clinical features of paediatric patients with chronic active Epstein-Barr virus infection (CAEBV) and to examine the effectiveness of the L-DEP regimen before haematopoietic stem cell transpla...
25 MG/M2, ON DAY 1, CYCLIC
DrugDosageText
CC BY
34112210
19,533,507
2021-06-10
What was the dosage of drug 'ETOPOSIDE'?
Outcome of L-DEP regimen for treatment of pediatric chronic active Epstein-Barr virus infection. We intended to investigate the clinical features of paediatric patients with chronic active Epstein-Barr virus infection (CAEBV) and to examine the effectiveness of the L-DEP regimen before haematopoietic stem cell transpla...
100 MG/M2, DAYS 1, 8 AND 15, ONCE A WEEK CYCLIC
DrugDosageText
CC BY
34112210
19,533,507
2021-06-10
What was the outcome of reaction 'Coagulopathy'?
Outcome of L-DEP regimen for treatment of pediatric chronic active Epstein-Barr virus infection. We intended to investigate the clinical features of paediatric patients with chronic active Epstein-Barr virus infection (CAEBV) and to examine the effectiveness of the L-DEP regimen before haematopoietic stem cell transpla...
Not recovered
ReactionOutcome
CC BY
34112210
19,533,507
2021-06-10