text stringlengths 14 151k | timestamp stringdate 2019-04-18 10:13:53 2019-04-26 17:26:58 | url stringlengths 14 895 |
|---|---|---|
We were barely at the October school holidays and already my son’s white shirts had started to look not so bright …. in fact some of them look kind of dirty. It must be a new record but we had officially reached that time of year where they seem more grey looking than white… and the lack of sunshine is not helping!
I have tried hot washes before but decided to bring in the big guns to brighten up these whites in a more eco way! By big guns, I mean the Good Housekeeping Institute Approved Ecover Bio Laundry Liquid and Ecover Stain Remover.
Ecover is a brand I have at home all the time, but I will be honest and say I did not get how a natural and eco-friendly brand could have a bio product…. this did not compute to me. Bio to me conjures up images of harsh biological washing liquids or bleach activated products that have traditionally aggravated my skin, let alone what they do for the environment.
This Ecover Bio Laundry Liquid is biodegradable, uses plant based ingredients, is suitable for sensitive skin and fabulously is housed in a bottle made from recycled and plant plastic! I used this liquid to tackle my son’s shirts first. Wow, no pre-soak, fabric felt as soft as normal after washing and most importantly the whites looked like whites!!!! Thank goodness!
I thought there would be a catch and maybe it would make my son’s skin itchy, but no this laundry liquid is kind to skin as well as tough on whites. One shirt came out needing a little more love. Yep….. it involves the black pen of course… but this particular shirt had a larger piece of “artwork” drawn on the back back by one of his mates. It turns out they weren’t meaning to draw on his shirt but they were fencing and the pen was the weapon! Silly me! I hate this pen. Can you tell?
I decided to put my Ecover Stain Remover to the test on this one. This award winning and effective product is made out of plant based ingredients, is septic tank friendly and fully biodegradable. It has a handy brush for application onto the clothes and can be used on stubborn stains like grass, mud, shirt collars, blood and also annoying black pen marks!!
I found it really easy to apply this stain remover straight onto the problem areas of my son’s shirt. I also used it on his red school sweathirt which had some grass stains on the front …. think victory slide along the grass and you will get what I am talking about. It worked a treat on the stains. No more black pen or grass, clothes are stain free and vibrant! None of the fabric was ruined and there was not a nasty chemical smell lingering about. Big thumbs up!
Have you tried this Bio Laundry Gel or Stain Remover? How did it stand up to the traditional toxic filled ones? | 2019-04-22T14:22:03Z | https://fififriendly.co.uk/2018/10/ecover-bio-laundy-gel-and-stain-remover.html |
Get an alert with the newest ads for Events in Grand Bend.
Post your classified or want ad in Grand Bend Events. It's fast and easy. | 2019-04-19T14:50:55Z | https://www.kijiji.ca/b-events/grand-bend/c289l1700190 |
How do you begin your journey to an Intelligent SOC? Start by evaluating where your dimensions of visibility, analytics, automation, and risk fall. With that knowledge you can build your roadmap in a sequence that delivers maximum impact and cost effectiveness.
Arthur Fontaine is Principal Product Marketing Manager for RSA NetWitness Platform. In this role he’s responsible for NetWitness platform marketing, focused on the integrated solution of RSA NetWitness Logs & Packets, RSA NetWitness Endpoint, and RSA Professional Services (Advanced Threat Detection and Cyber Incident Response). Arthur has extensive experience in the technology industry, including 20 years at IBM in a variety of product roles, working on security, collaboration, and hardware offerings. He began his technology career in telecommunications, with NYNEX (now Verizon) and Northern Telecom. He holds an MBA from Anna Maria College and a BA in English Literature from the University of New Hampshire. | 2019-04-21T12:17:56Z | https://community.rsa.com/events/3234 |
This aluminium pen is packed with gizmos and gadgets. First and foremost this is a pen - a nice writing pen - it is also a tablet stylus, a micro screw driver set, a ruler and a spirit level. Available in black or silver this gadget pen is a great gift idea for the articulate thinker. | 2019-04-26T10:07:38Z | https://www.mudgeearthouse.com.au/products/gadget-pen |
The annual Soo Finnish Nordic Ski Club banquet will take place on Sunday, April 8. Tickets are now available online at Zone 4.
Menu: Pasta & meatballs, roast chicken & potatoes, vegetable, salad, dessert, and coffee/tea. | 2019-04-26T09:55:49Z | http://soofinnishnordic.com/?p=3685 |
BRAZILIAN DIET MEAL PLAN – LOSE 12 KG IN 1 MONTH!
| Weight Loss | BRAZILIAN DIET – LOSE 12 KG IN 1 MONTH!
The Brazilian diet meal plan is considered as a standout because of its quick and promising outcomes. You can lose 10 kg in only 2 weeks if you stick to the diet!
There are two versions of the Brazilian diet meal plan: quick and normal.
The quick version can negatively affect your wellbeing which is the reason we’re not going to specify it here. We will discuss the normal version which is for the most part comprised of vegetables and fruit. It has 4-5 meals and if you stick to them, you will definitely have amazing outcomes.
You should follow this Brazilian diet for two to four weeks, no more. You can be physically active if you want to achieve better results.
After the diet, you should stick to eating more veggies, fruit, and protein. | 2019-04-24T02:37:06Z | https://ladiesnutrition.com/2017/01/18/brazilian-diet-lose-12-kg-1-month/ |
President Mahinda Rajapaksa has stripped Mervyn Silva from his deputy minister post and the Sri Lanka Freedom Party has cancelled his party membership, President’s media told a short while ago.
Well done. Now need to find his son Malaka. Both of these goons will now get what they truly deserve, public shame.
cricket board get rid of corrupted officals.
Great,,This monster is a black mark to Sri Lanka.
like Mervyn , people is necessary for corrupted officers in Sri-Lanka.
Definietly this is another ride for SL’s.
Do not worry,Its you are the best back boned person in the Parliament.This is not the end of your carer.just try to find to com up from the fallen downed well.
Great Job Mr President. This IDIOT played fool thruoght out his carrier which brought shame to our great country & great people. SHUT your stupid mouth & get lost now MERVIN.
Mr Mervin. stand up with a courage.You always stood for the right.Supplying more and more beautiful ones to the….. will definitly help you to regain everything. keep on suplying needed angels…. O.K.
Sad to see Mervyn Silva end his brilliant career in this manner. Mervyn reflected society’s true frustrations. The public servant’s response to the dengue epidemic was pathetic. They are good at attending meeting whilst the Sinhala Buddhist population were dying like flies.
Mervyn’s reaction to the callous approach of the public service to the dengue epidemic is understandable. I, as a long suffering Sinhala Buddhist citizen of the Sinhala Buddhist Republic of Sri Lanka, empathise with him.
Mervyn reacted similarly to the destructive journalism of Rupavahini bureaucrats some time ago.
The problem is that we use the decadent west’s scale to measure our behaviour. And funnily enough, the decadent west has different standards to behaviours all over the world. For instance, the US commits war crimes in the open in Iraq and Afghanistan. No complaints about that. Their leader, President Obama, was even honoured with the Nobel Peace Prize!! When HE President Mahinda Rajapaksa eliminates the Terrorist Tamil Movement and its Sun God Leader, the west is after his blood for war crimes.
When Hon Wimal Weerawansa protests against an unlawful action of the UNSG, the west and its followers in the Sinhala Buddhist Republic of Sri Lanka, raise their eyebrows.
Mervyn Silva is a colourful and patriot leader who dealt with unsavoury happenings with passion and fervour. His unsurpassed commitment to the Sinhala Buddhist Citizens of the Sinhala Buddhist Republic of Sri Lanka will be cherished for ever and for ever.
I propose that his career be honoured by offering a scholarship to political science undergraduates in a university.
abeykoon from Aus have u seen in here anyone who done something wrong will the Australian companies tie them to the trees. What will you do if your father didn’t go to work because u came from Australia and Mervin Silva ties him to the tree. what will you feel? Where is the law? Or you still like the old law? Have u seen keving rud got punished becuase he didn’t do his job. So don’t u support for kevin rudd, since u stand as abeykoon from Aus not sri lanka. Please think before u write. If government servent has done something wrong, try act as the modern policies.
Note: How much is the government servent get paid? DO they have mobile phones and landlines? Who will take the responsibility of answering the call in government offices?
You live in a country ruled by the white men who committed significant human rights violations against the indigenous people of the land. The Prime Minister who had the courage to stand up and apologise to the indigenous people has been politically assasinated into oblivion.
Two things I wish to reiterate.
1) Mervin Silva is a hero representing the common Sinhala Buddhist masses of the Sinhala Buddhist Republic of Sri Lanka. Mervin stands against the tyranny of the public servants who never, ever care for the Sinhala Buddhist people. Had the public servants done their job properly without fear or favour, the Sinhala Buddhist Republic of Sri Lanka would now have been the true pearl of the Indian Ocean. Had the public servants done their job properly, even the late Sun God would not have been born to terrorise the Sinhala Buddhist Citizens of Sri Lanka.
2) The Sinhala Buddhist Republic of Sri Lanka belongs to the Sinhala Buddhist Citizens. The war aginst the terrorist tamils successfully carried out by HE President Mahinda Rajapaksa has proved this fact. The Commander of the Armed Forces who carried out the war said this in public while the war was being fought. The remnants of the terrorist tamil population is now in barbed wire camps and they shall be kept there for ever and for ever. The lands and wealth illegally used by the terrorist tamils should be returned to the rightful owners, the Sinhala Buddhist Citizens of the Sinhala Buddhist Republic of Sri Lanka without any further delay. Hon Namal Rajapaksa should be made the Executive Prime Minister to carry out the remainder of the excellent work done by his illustrious father, HE President Mahinda Rajapaksa.
Every family has a black sheep. Mervyn is unfortunately the BS of the SLFP. HE the President has long tolerated Mervyn due to longstanding friendship. However, enough is enough. The summary justice Mervyn meted out on a hapless local official who Mervyn perceived as having defied his diktat was the last straw.
Mervyn has a history of being a maverick within the party. He has thus brought ignominy to his party and the government. He is led by his emotions than his intelligence. He has a reputation of hobnobbing with mafia thugs who provide him with a private militia of gorillas in return for his ‘protection’. Mervyn is not alone in this type of low-brow politics.
Under Mahinda Chintanaya there is no room for this type of mavericks who follow there own agenda led by their emotions. Everyone in UPFA must work in unison to make Mahinda Chintanaya a success for the good of the motherland. We cannot sit on out laurels now that the LTTE is vanquished and VP has been sent to hell where he belongs. Wake up! LTTE is being resurrected like the proverbial phoenix. they have billions of dollars in their secret bank accounts in the West. KP has been cunning in playing along and deceiving the government into thinking he is playing ball with them like Karuna. Actually he is not. KP is an evil, crafty sod. He is secretly plotting the demise of MR and the government even though in captivity with all the creature comforts perhaps. He pretends to give valuable information about LTTE bank accounts and assets when he has not. LTTE ships are carrying on business as usual, ferrying LTTE escapies to Canada to plot the next militant uprising in SL to capture the whole of the island for their Tamil Nation or eelam empire which encompasses Tamil Nadu also. Anandasangaree, Dharmalingam, Devananda et alia, who fled from VP, are joining forces with TNA to clamour for Tamil nationalism once again. The ordinary Tamils do not want it. They recognise themselves as Sri Lankans working in harmony for a better future for themselves and their children in a united SL. Unfortunately, the Tamil nationalism card is being played again, supported by the imperial West who have their own hidden agenda for SE Asia dominated by USA as superpower. USA hidden agenda is to engineer break-up of India into autonomous States so that India can never be a superpower.
MR through his Mahinda chintanaya is a serious threat to the aspirations of USA and the imperial West. It is paramount therefore that SL remains united as one multi-cultural and multi-racial nation. Mavericks like Mervyn is a thorn on the side of the government in its fight against the enemies of SL. They fail to see the bigger picture. We cannot have indiscipline within the party and the UPFA government. It is quite right therefore that HE the President stripped Mervyn Silva of his cabinet position and suspended him from the SLFP till the outcome of a disciplinary hearing. MS can ofcourse make it worse for himself by joining forces with the enemies of UPFA and motherlanka such as SF, Avamangala, Ranil, Ravi, Karu, TNA, diaspora Tamil LTTE, imperial West et alia.
I am replying for a post in the thread, I don’t have a hope in government. If you strip off the position you should cancel the security and facilities. If somebody sack mervin how he still praise government. Thats not how he behave. I hope as a educated person in your educated brain can understand this….
Don’t think Mervin will be out for long…. | 2019-04-25T02:21:22Z | https://www.onlanka.com/news/mervyn-stripped-of-deputy-minister-post-slfp-membership-cancelled.html |
-44 windchill... Gonna take some real work to get large areas above average in snowfall this season.
Wow. No wind here currently so a temp of -14 yields a WC of -18. Feels warm!
We’re already 14” below normal at MSP. Headed for a third straight year well below normal snowfall.
What is MSP's season total thus far???
The heart of the arctic cold is centered over Montana and taking the reign as the coldest readings this morning across the north. Some spots are approaching temps of -40F! Ouch! Locations in the eastern part of the state and western ND are in the epicenter at the moment directly underneath the monster HP.
ORD just dipped to -9F and approaching the record of -10F for the date...it's interesting that the temp has dropped even though the sun is up over the horizon.
It is -8F in Topeka, KS with no snow OTG (just patches of snow). Can you imagine how cold it would have been if they were to have 6" OTG??? Fast forward this pattern in mid/late Feb with snow OTG and you can let your mind wonder.
Speaking of snow, the system that has been showing up on the models for a few days now towards the tail end of this weekend, looks like the northern energy may be the dominant player. If we were to take the LRC cycle (centered around 47-79 days), there was a system that tracked north of MN Nov 23-24 towards Ontario. Due to seasonal shifts and blocking, this system seems to be tracking a bit farther south now and will impact mainly our eastern sub forum region. There was also a southern piece that didn't quite phase with this system back in Cycle 2 and the 00z Euro was hinting at this so that is something to look for.
Officially 7.1” at the airport. 21.8” is normal to date. But the airport always seems to be a spot with lower totals than everywhere else.
I think its time to turn things around! Later this weekend is the next opportunity I think for you.
Parts of northern FL gets accumulating snow.
Currently @ 7F w great snowcover around.
Arctic express roars in by midweek after a weak clipper passes on by on Weds and crashes my temps even furthermore.
Here at my house for the 2nd nigh in a row received 0.25” of new snow. And with the light snow I am getting at this time it now has snow here in Grand Rapids ever day for the last 12 days. With the compacting of the snow I now have 10.5” on the ground here. December mean temperature was 24.4° making this the coldest December here since December 2000, That December Grand Rapids recorded 59.2” of snow fall BUT January 2001 there was only 4.1” of snow fall.
The Cedar Rapids airport bottomed out at -24 (all-time record is -29). Here in the city the range was -17 to -21. I'm not sure how cold my yard gets relative to others.
Cedar Rapids was already -22 before midnight, so a new daily record was set for both December 31st and January 1st. Another record may be set tonight for Janauary 2nd.
I'm sure the east coast snow geese are salivating for this thing to track farther west. What a tease this would be to track just enough far offshore to only graze the Boston area.
Despite all these record bitter temps, our frost depth is practically non-existent and one reason I'm not a fan of flips to cold with snow fall immediately following. Much prefer 5-7 days of freezing temps prior. Need a good 6+" of frost to protect against the dreaded melting from both sides that caused our first snow pack to vanish so quickly.
Last year the high was 39 the low was 23 and there was no snow on the ground.
Side not as Jaster220 stated the ground is not frozen very deep here in west Michigan and that is true in much of norther Michigan as well as we get snow cover way before the ground gets very cold.
Happy New Year! Like many on here, I'm always impressed with your stats. Keep up the good work in 2018! BTW, I would love to be in your position and have the streak of days with snow falling at your place. This week, I'm sure your going to add in that dept with the LES that is forecast to hit around the Wed-Fri period.
Forgot to say what the temp was on my balcony this morning! Oh well. Right now it is -8 but the wind is calm.
I didn't know we were racing. Dude, you are in a snowbelt area, how can you possibly compare SWMI w SEMI and have hopes to BEAT me. If you like racing so much, let me know other ways you like to challenge me! Us New Yorkers have many possible ways.
Currently, at 10F w a slight breeze. Plenty of Sunshine.
Why not...The Atlantic Ocean is what helps them get the "Big Dogs". Nothing wrong w that. You get moisture from there and GOM and you get a major EC snowstorm. Of course, getting the benchmark track plays a big role.
Don't have a good feeling about this. I think this will be another S MN special which misses a lot of us.
Already snow down at h144! Someone in MN should take the lead and kick off a thread!
12z GEFS look better down this way actually...let's see what the 12z Euro shows in a bit.
Looks like a lot have a stronger southern low?
This! They've gotten your BD's. There has developed a major imbalance from Neb to Maine with a total bias to greater frequency of BD's. The further east you go, the greater the bias has accumulated. Someone from that sub posted last winter that Eastern Long Island up thru Boston and Maine was running 400% of normal for BD's since that streak began. Crazy stuff! I'd argue that everyone in this sub west of MI deserves a BD before that region cashes in again. I'd like to see one of those peeps endure what you Plains peeps have gone thru. Doubt they'd make it tbh. Would certainly change their perspective!
More southern members showed up this run and seem to have that look the 12z GGEM showed.
Why are they weenies? You are not??!! Have ya ever lived there? Probably not!
Do you have the total snowfall for the ensembles by any chance?
Gorgeous day today w plenty of sunshine and temps in the teens. Tbh, I have gotten used to this frigid weather now, so it feels nice out.
Have lots of guests coming today. I am hosting friends and family. Busy day on tap. Hopefully, they leave early.
Indeed, both UKIE and Euro showing the CO Low feature. Let’s see where this goes. | 2019-04-23T03:53:04Z | http://theweatherforums.com/index.php/topic/1706-january-2018-observations-and-discussions/page-3 |
a wall of photographs of women taking birth. This piece was initially intriguing because I assumed all of the pictures did not have a theme. There was a shock when I realized it was all women giving birth, a normally stigmatized and alarming sight and then there was relief because it’s the one universal action that has been taken for life to become life.
These vintage pictures against yellow paper was stark and beautiful. I think they represent the era in a nostalgic way that reminds me of a film reel.
The composition of this is alarming yet calm. The blood splatter and close angle are mixed with the solid figures standing. | 2019-04-21T10:57:48Z | http://portfolio.newschool.edu/nortm475/2018/07/15/95/ |
“With or without a decorated tree, you have a home ready for the holidays with minimal effort,” she says.
Barbara Rodts of Leawood is sold on deep-frying the turkey. It tastes great and gives the menfolk something to do outside, monitoring the fryer. Most important, it frees up the ovens to prepare the rest of the meal. The biggest holiday meal challenge is having all the parts ready at the same time.
For presents, Sue Farley, who lives near Weatherby Lake, has switched from gift bags to reusable shopping bags — two gifts in one, and cheaper. Sarah Beyer of Leawood uses newspaper for gift wrap. Louise Meyers at Pryde’s in Westport buys rolls of holiday-colored cellophane for quick and easy wrap jobs of baked goods and other stuff.
“It’s saved my life many a time,” Meyers says.
We think she’s exaggerating. But this is the way people talk at holiday time. Maybe some simplifying will save you.
Two words, one hyphenated: three-ring binder.
Or its digital equivalent. This does not make you a holiday nerd. Rather, your mind can relax a bit if your plans are written down and all in one place.
The heart of holiday meals is traditional and predictable year to year, so maintain a holiday meal master grocery list in your binder or on your laptop. Take the list to the store early so you can spread out the expense. Buy and store a little at a time, including wine and liquor.
(if not this year, then next). Even rolled-up newspaper works.
— an ornament per slot — aren’t expensive and make decorating and undecorating the tree much less of a chore. If you have hundreds, or thousands, of ornaments, they might not be practical.
— assuming you don’t need the table for daily use — when there is time to make it pretty. On the “day of,” let it be a decorative highlight.
Choose three elements and repeat.
For December, pick beautiful ribbons, pine cones and candles, say. Now you have a theme and a holiday signature. Place arrangements of these in several locations around the house.
Focus on four or five areas for treatment and leave the rest alone.
No need for holiday tchotchkes on every horizontal surface. Walk the house and choose your “impact” areas, including a wall near the front door, the entrance to the dining room, etc. Do a swag over a doorway, say, and spread some greenery around a Santa collection in the kitchen.
of varying lengths to ornaments or anything else — cookie cutters, pine cones, berry bundles — and hang from a chandelier or next to a window.
Shiny dishes, sparkly glasses and richly colored cloth napkins already adorn the table, and you need most of the space for the food, anyway. So just make one or two conspicuous strokes, such as a baby pumpkin at each place setting and leaves, fake or real, around the turkey platter. Find a southern magnolia tree in the neighborhood or do a little pruning on your holly or azalea bushes.
, which can take just 90 minutes in an outdoor fryer, thereby freeing up your ovens for vegetables and casseroles.
Most oven-baked items can be prepared early, refrigerated and heated.
Use your slow cooker, too.
, but carefully or they’ll come out hard and dry. Wrap the basket in a damp cotton towel, and mind the time.
Say it three times: It’s OK to buy pies. It’s OK to buy pies. It’s OK to buy pies.
They’re darn good from your favorite local bakery, supermarket, Upper Crust in Westport and Overland Park, Tippin’s, Costco and so forth.
, for recipes that combine packaged and raw ingredients and save time. Google “cake mix cookies” for easy cookie recipes that start with cake mixes.
Make cookie-baking day simpler by preparing the dough a few days ahead.
Keep it in storage bags or reusable plastic containers in the refrigerator.
, which makes it timelier than the vacation photo, and you’re probably better dressed.
who don’t need more stuff. If they live in town, schedule a fun outing with them to buy toys and clothes for agencies that help families. It’s a great feeling, too.
Save newspapers, including advertising inserts, and use them as gift wrap. Try matching the newspaper to the recipient, outdoor article with photos for the nature lover, say, or jewelry ad for the person who likes sparkle.
So: one artsy bow, one tied ribbon, one silver bell. Use old Christmas cards, and, again, try to match image with recipient.
More than a few of you already do this, so maybe this serves as permission for the rest. Many are just 99 cents; others are fashion statements.
, and use them every year for family members.
Sarah Beyer of Leawood, Paula Burger of Lee’s Summit, Sue Farley of Platte County, Jayne Gier of Kansas City, Brenda Lall of Overland Park, Louise Lloyd of Shawnee Mission North High School, Louise Meyers of Pryde’s in Westport, Barbara Rodts of Leawood, Ann Roll of Kansas City, Diane Stewart of Color Sense Consulting. | 2019-04-21T19:24:39Z | https://www.kansascity.com/living/article299706/Simplify-your-holiday-season.html |
Broken Screen HD Desktop Background Wallpapers - You're currently on page Broken Screen HD Desktop Background Wallpapers with ID 3007 in Amazing Wallpaperz. Amazing Wallpaperz provide high-resolution images that are very suitable for computer, tablet or smartphone. Wallpaper that we provide is a wallpaper that has a high resolution, but the size is not too big so it will not spend memory on your gadget. If you are interested in this Broken Screen HD Desktop Background Wallpapers picture you can click on the "Download" link below to open full size images. If you are interested in other high-resolution images you can get it in Amazing Wallpaperz. If you liked this wallpaper you can share it with your friends on social media via the button below. We always respect the copyright owner of an existing image. No copyright infringement intended. All copyright goes to their rightful owner(s). If the load when the image is too long, perhaps the size of the image is too big or interference from the server, we greatly appreciate your patience, your patience as we will work even harder. Thank you for visiting Amazing Wallpaperz. | 2019-04-21T06:46:03Z | https://www.amazingwallpaperz.com/broken-screen-hd-desktop-background-wallpapers/ |
Established in 1995, TQPR Thailand has steadily grown to become one of the Kingdom’s leading communications consultancies. The firm is dedicated to providing the highest quality communications services to local, regional and global clients.
TQPR has advised Nissan Motor Thailand since 2017 on its Thailand and international media profile. Acting as an advocate outside of its home market, TQPR helps enhance Nissan's brand position as the market leader in innovation and technological development.
TQPR has been advising Expedia on how to capture a greater market share of Thailand's dynamic travel sector. The team helps Expedia understand B2B market specifics in Thailand via ongoing media relations work..
TQPR collaborated with our PR affiliate, Burson Cohn & Wolfe (formerly Burson-Marsteller), in Singapore to provide Rolex with strategic counsel about Baselworld. Joint PR activities included story pitching, press release distribution and monthly meet up with individual editors.
TQPR advises Western Digital on corporate communications in addition to co-ordinating product placement, promotions and identification of correct product demographic.
TQPR advised and then assisted Agmen conduct strategic stakeholder analysis and mapping for the company and its operations in Thailand.
Banking industry titan JP Morgan worked with TQPR to create brand awareness in Thailand.
TQPR helped Siam Winery build global awareness about Thai wine right when it was launching operations. It helped build brand equity and added product value to Siam Winery while navigating Thailand's advertising restrictions. | 2019-04-26T15:57:39Z | https://tqpr.com/tqpr-thailand/ |
Please be advised that the United Way of Denton County is now accepting applications for the new DHA Supportive Services Community Impact Fund. Please submit applications via email to Leah@UnitedWayDenton.org no later than 5:00 p.m., Friday, April 27th (PDF only; do not submit paper copies). An optional (but highly recommended) grant training will be offered on Monday, April 9 at 10:30 a.m. at the United Way of Denton County office (1314 Teasley Lane, Denton, TX 76205). For inquiries about grant requirements, please contact Courtney Cross via email at Courtney@UnitedWayDenton.org.
Please visit our website for Agency and Client eligibility requirements, and to download an application form.
Funds may NOT be used for furniture, clothing, or the purchase of a home or vehicle. There are no match requirements for this grant. Up to 5% of funding may be used for indirect (administrative) costs.
Previous Previous post: A quick easy way help people experiencing homelessness get housed. Give to the barriers fund today! | 2019-04-24T05:56:31Z | https://endhomelessnessdenton.com/2018/03/28/accepting-applications-uw-community-impact-fund-dha-supportive-services/ |
Definition - What does Asia Pacific Network Information Centre (APNIC) mean?
The Asia Pacific Network Information Centre (APNIC) is an organization that manages the assignment of Internet number recourses within the Asian continent.
APNIC sets the rules, regulations and standards that all designated organizations must abide by and implement. End-user organizations and Internet service providers take direction from Regional Internet Registries (RIRs) like APNIC to provide Internet resources within certain regions. The Internet number resources include antonymous system numbers as well as IP addresses that assist in clearly defined routing policies and numbers corresponding with individual computers or other devices.
One of the purposes of APNIC is to provide standards-based inter-networking methods for the Internet such as IPv4 and IPv6 across networks such as Ethernet. This uses a best-efforts delivery model for private networks or multicast addresses by using a 32-bit integer.
APNIC serves a multitude of organizations who use autonomous system numbers (private) that all connect to the Internet. APNIC also serves as the Whois database within the Asian continent, storing regional domain names and IP addresses and accepting queries.
APNIC provides a reverse pointer record, or reverse domain name service lookup, which associates an IP address with its domain name. | 2019-04-21T10:04:40Z | https://www.techopedia.com/definition/2477/asia-pacific-network-information-centre-apnic |
ALL NATURAL SHAVE OIL — CROWNE & COMBES INC.
This shave oil is formulated with only the finest natural blends of oils. It helps to soften the beard and prepares the skin for a close and comfortable shave. Made with 100% all natural ingredients such as Argan, Grapeseed and Almond Oils. This shave oil is ideal for men with sensitive skin, ingrown hair, razor burn or tough beards, helping the blade glide over the skin.
It leaves your skin feeling icy and fresh with our polar bomb scent. | 2019-04-24T04:22:42Z | https://www.crownecombes.com/store/all-natural-shave-oil |
On Sunday, April 13th, SJLC will be having its annual Children's Easter Egg Hunt. The event will begin directly after our Palm Sunday Service. Last year's hunt had over 200 Easter Eggs to be found! All children are welcome!
This year's Easter Egg hunt was another great success! Great weather, nearly 300 eggs to find, and several SJ kids hunting them down. Thanks to all the volunteers for making this possible! | 2019-04-26T12:02:00Z | http://www.stjohnslutheranwinchester.org/whats-new/childrens-easter-egg-hunt |
The robust quality standard that recognises excellence in leadership and management training programmes that don’t lead to a regulated qualification.
Great training comes in all shapes and sizes. We understand that formal qualifications are not the only way to develop talented people and recognise high quality training. Sometimes you need the freedom to decide the content, format, and length of your training.
Whatever your organisational development needs, the key to maximising impact is high quality delivery.
ILM Assured provides the knowledge and experience to shine a light on great leadership development.
How does ILM Assured recognition work?
From short courses and induction training, to longer-term development plans, this flexible solution provides a mark of excellence that will set your training apart.
A dedicated account manager to support you every step of the way.
To attain the ILM Assured standard a training programme must meet the competency criteria listed under each benchmark component. To maintain consistent quality and Assured status your programme will be reviewed by a quality professional annually.
If your programme is not a leadership and management development programme it may still be eligible to become City & Guilds Assured.
See the detail that sits behind our new recognition service for non-qualification training.
ILM Recognition provides quality assurance service essentials for organisations looking to enhance their programme's status. New approvals for ILM Endorsed and Development programmes through ILM Recognition in the UK will cease from 1 September 2018.
If you're interested in finding out more about the ILM Assured recognition service and how it can work for your organisation, please get in touch. A dedicated account manager will be on hand to take you every step of the way. | 2019-04-19T01:36:09Z | https://www.i-l-m.com/supporting-employers/ilm-assured |
Bath Tile. look the best Unique Home Design especially the post about Bath Tile for inspiration and informational to your home only in Unique Home Design. Bath Tile presents an honest image quality and interesting will offer you with satisfaction in reading it. images and photos collection posted here was carefully selected.
See this list of amazing image and picture of Bath Tile part of Unique Home Design gallery exclusive and best collection. Find the best Bath Tile image and photos posted here for your own collection and personal use. The Unique Home Design group hope that you enjoy your visit here and if you need to get the pictures in high quality, simply just click the link below the images gallery of Bath Tile. | 2019-04-25T22:37:59Z | http://a-p-groupe.com/bath-tile/ |
Google has swapped out the now-antiquated Currents to offer a much more comfortable and personalized reading experience to bring the news that interests you to your device. Now, using Google Play Newsstand, you’ll have access to the current events publications most closely related to what you’re looking for with the option to customize the content—and all of this is totally free (although there is some information that you’ll only be able to access by paying).
This new app offers you the possibility of consuming all the information you access throughout the day on diverse media but with the benefit of bringing it all together in one app that you can keep open all the time. In addition, the interface is very comfortable, and shows you news headlines organized by category, by source publication, or by the time of posting.
You can access newspapers of various types, including general information, specialized information, blogs, magazines, and general news sites, all of which are ordered by category and by news relevance, with the option to specify whether you prefer latest news or highlighted publications.
With each category you can also access loads of related content on a subject you wish to read about, thus making it easier to access the news that interests you and, in passing, other news you might not be looking for but that might still interest you.
It’s worth noting that Google Play Newsstand maintains all the subscriptions that you may have stored in Google Currents and Google Play Magazines, meaning you’ll keep receiving all the news that interests you direct to your device.
Finally, Google Play Magazines users should note that they can access the new app just by updating their current app. Users of Currents will need to download Newsstand to replace the outdated app. | 2019-04-21T04:06:56Z | http://blog.en.uptodown.com/google-launches-play-newsstand-to-substitute-the-old-currents-and-play-magazines/ |
This post originally appeared at The New York Times.
Last week’s proposal by the Federal Communications Commission to allow Internet service providers to charge different rates to different online content companies — effectively ending the government’s commitment to Net neutrality — set off a flurry of protest.
The uproar is appropriate: In bowing before an onslaught of corporate lobbying, the commission has chosen short-term political expediency over the long-term interest of the country.
But if this is the end of Net neutrality as we know it, it is not the end of the line for fair and equitable Internet access. Indeed, the commission’s decision frees Americans to focus on a real long-term solution: supporting open municipal-level fiber networks.
The commission’s decision frees Americans to focus on a real long-term solution: supporting open municipal-level fiber networks.
Such networks typically provide a superior and less expensive option to wholly private networks operated by Internet service providers like Comcast and Time Warner.
The idea of muni networks has been around for a while, with bipartisan support. When the Telecommunications Act was under discussion in 1994, Senator Trent Lott, Republican of Mississippi, was one of its most enthusiastic supporters. Thanks to him and others, the act, passed in 1996, prohibits states from putting up unreasonable obstacles to any entity that wants to provide telecommunications services.
So why didn’t a thousand muni networks bloom? After all, the 1996 act was aimed at increasing competition. But private providers rightly recognized muni networks as a threat and in the subsequent decades have pushed through laws in 20 states that, despite the 1996 act, make it difficult or impossible for municipalities to clear the way for the sorts of networks that the 1996 act envisioned.
Watch how Lafayette, Louisiana prepared to get its fiber-optic network.
That means that the main problem behind getting muni networks up and running isn’t about the technology — which not only exists, but is already being used in large and small cities around the world — but about the politics.
Mere legislative change won’t be enough, however. We need to elect leaders on the basis of their commitment to changing America’s stagnant communications infrastructure.
There is much to be done at every level of government, but cities are the most promising battleground right now. Mayors, Republican and Democrat alike, are in the business of providing their citizens with services, and fiber infrastructure is just like a city street grid: Economic development, quality of life, new jobs and a thriving competitive market all depend on its presence.
Mayors, Republican and Democrat alike, are in the business of providing their citizens with services, and fiber infrastructure is just like a city street grid: Economic development, quality of life, new jobs and a thriving competitive market all depend on its presence.
Most important, cities have assets in the form of control over conduits, poles and rights of way that can be used to support the provision of competitive fiber-optic networks. Since 1998, my hometown, Santa Monica, California, has been saving money by shifting from paying expensive leases on private communications lines to using its own fiber network, called City Net.
The city planned carefully and built out City Net slowly, taking advantage of moments when streets were being opened for other infrastructure projects. Businesses in Santa Monica now pay City Net a third of what a private operator would charge and the city government has made millions leasing out its fiber resources at reasonable rates to other providers.
According to Christopher Mitchell of the Institute for Local Self Reliance, a national expert on community networks, more than 400 towns and cities across America have installed or are planning networks. And that’s not just good for consumers; it’s good for business. Companies are moving to places like Wilson, North Carolina and Chattanooga, Tennessee, because those cities provide public, inexpensive, high-capacity connectivity.
American cities need fast, cheap, ubiquitous, open fiber networks and every city has the tools at its disposal to get these networks built. But there are powerful and well-funded incumbents who will fight any mayor brave enough to consider the idea. If you’re furious about your cable bill and worried about Net neutrality, go tell city hall. | 2019-04-24T08:58:37Z | https://billmoyers.com/2014/05/01/the-wire-next-time/ |
Our mission is simple: provide quality services that revitalize, rejuvenate, and relax our guests.
Below is a list of the most common services available at our spa. For a comprehensive list of all the services that we provide, please visit our location. Please note that each location may vary slightly in services offered.
Our recommended service for guests who wish to enhance the natural form of their nails. This product is applied in liquid form and cured under an LED lamp.
Our recommended fill in time for the liquid gel service is three weeks.
LCN Gel is the highest quality gel currently available. After curing under an LED lamp, the gel develops pores, which allows for the lightest feeling nail enhancement while maintaining strength and a natural look.
Our recommended fill in time for the LCN gel service is three weeks.
Our acrylic nail enhancement uses polymer powder and monomer liquid to strengthen and extend natural nails. This service does not require curing under a UV lamp.
Our recommended fill in time for the acrylic service is two weeks.
The classic lash set extends your the natural curl of your lashes. This gives your eyes a full look.
The classic curl lash set compliments the length of the eyelash extension with additional curl.
The volume lash set is for someone who wants a full and bold look for their eyes. This is achieved with more extensions per lash than other sets.
The classic curl lash set has look of the classic curl set with real mink lashes.
Cluster lashes. No fill ins for this type of set.
Tint your eyebrow shape. Multiple colors available.
Paraffin dips helps moisturizers and lotions absorb into the skin through heated wax. | 2019-04-24T22:50:16Z | http://www.luxe-nail-spa.com/service-no-prices/ |
This 3D printed geodesic dome is an engineering marvel and incredibly fun to assemble. The hubs and the straws press fit together. Follow the included instructions and you will have a dome in no time. This is a great science project, or just for fun. You'll be amazed at how strong straws become when assembled this way.
The kit includes all the hubs you need, pre-cut straws, instructions and spare parts.
Hubs may be in random colors. Ships to US only. | 2019-04-19T00:24:00Z | http://www.sketchthis.net/store/mini-3d-printed-geodesic-dome |
Have you been stretching with minimal results?
Do you want to achieve greater range of motion safely?
Do you want to get strong and flexible at the same time?
If yes, MOBILITY UPGRADE is for you!
Join Lisa in a workshop series designed to help you move and function at your best. This progressive series uses scientific principles to improve joint-health and Active Range of Motion. Using a variety of safe training methods from Functional Range Conditioning® developed by world-renowned musculoskeletal expert Dr. Andreo Spina, Lisa Messina (FRCms) will guide you though the foundations of this results-driven practice and teach you how to progress based on how your body responds.
Participants will receive a daily mobility training practice video and are encouraged to follow it once a day for desired results. | 2019-04-23T16:39:44Z | https://www.lisamessina.com/workshops |
in difficult conditions: an open cohort study with a mean follow-up of 2 years.
Int J Oral Maxillofac Implants. 2012 Sep-Oct;27(5):1177-90.
edentulous atrophic maxillae with immediately loaded extra-maxillary zygomatic implants.
Eur J Oral Implantol. 2012 Spring;5(1):37-46.
and all-ceramic crowns: retrospective clinical study with up to 10 years of follow-up.
J Prosthodont. 2012 Jun;21(4):256-64. doi: 10.1111/j.1532-849X.2011.00824.x.
a 5-year retrospective study and a new classification.
Eur J Oral Implantol. 2011 Autumn;4(3):227-43.
a clinical report on the medium (3 years) and long-term (5 years) outcomes.
□Short implants in posterior jaws. A prospective 1-year study.
Eur J Oral Implantol. 2011 Spring;4(1):47-53.
with up to 10 years of follow-up.
J Am Dent Assoc. 2011 Mar;142(3):310-20.
□A new approach for maxilla reconstruction.
Eur J Oral Implantol. 2009 Summer;2(2):101-14.
supported by four implants: interim results of a single cohort prospective study.
j.1600-0501.2009.01852.x. Epub 2010 Jan 22.
a retrospective clinical study with up to 11 years of follow-up.
Clin Implant Dent Relat Res. 2011 Jun;13(2):95-103. doi: 10.1111/j.1708-8208.2009.00188.x.
in immediate function: a pilot study.
J Prosthet Dent. 2008 Nov;100(5):354-66. doi: 10.1016/S0022-3913(08)60237-1.
a five-year retrospective and one-year prospective study.
J Prosthet Dent. 2008 Mar;99(3):167.
to support a fixed denture: preliminary results after a mean follow-up period of thirteen months.
for rehabilitation of partial edentulism: a prospective cohort study with follow-up of 1 year.
Eur J Oral Implantol. 2008 Winter;1(4):293-304.
with 1 to 9 years of follow-up.
Clin Implant Dent Relat Res. 2007 Mar;9(1):15-21.
using a new implant design: case series.
Clin Implant Dent Relat Res. 2006;8(4):223-32.
for completely edentulous maxillae: a 1-year retrospective clinical study.
Clin Implant Dent Relat Res. 2003;5 Suppl 1:37-46.
for completely edentulous mandibles: a retrospective clinical study.
Clin Implant Dent Relat Res. 2003;5 Suppl 1:2-9.
Copyright マロ・クリニック東京. All Rights Reserved. | 2019-04-21T20:19:15Z | https://www.maloclinic-tokyo.com/paulomalo/ |
Our Bespoke industrial aprons are produced in plain PVC and are available in various colours. Our PVC aprons are widely used in the industrial food sector, and we have manufactured heavy duty bespoke aprons for many years. We can accommodate large or short production runs to meet customer requirements.
We can provide aprons for Children, Men and Women.
Our custom made industrial aprons can be used for anything! From cooking to industrial, our aprons are the perfect product to protect your clothing.
With ties at the back for a comfortable fit our bespoke industrial apron can be adapted to suit any customer and can even include a pocket at the front for storage. | 2019-04-19T02:32:50Z | https://stuartcanvas.co.uk/industrial-aprons/ |
A mug dedicated to the most important ritual of the day… coffee! For through coffee all things are possible. This mug is perfect way to let your friends and family know you’ll be ready after you finish your coffee.
These mugs are printed on both sides and are dishwasher and microwave safe. The graphic will not wash off or get damaged in the microwave. Do not bake. | 2019-04-25T05:52:53Z | https://toughbydesignsports.com/product/runner-loading-please-wait-mug/ |
Suitable for: Any individual who would like to precisely measure their resting metabolic rate for body composition and health related goals.
An understanding of your energy needs provides a sound scientific basis for any weight loss or maintenance plan. This technique, which involves resting on a bed for 30 minutes combined with an assessment of your daily lifestyle energy requirements, will provide an accurate assessment of your daily caloric needs. Knowing your energy expenditure can allow you to then compare against your energy intake, providing a more accurate means of determining caloric requirements if you are wishing to lose, maintain or gain weight. | 2019-04-25T00:31:08Z | https://www.westminster.ac.uk/business-services/health-and-fitness-services/health-services/resting-metabolic-rate |
EvelynPaz . KHATTYSWEET. Wolnah. FeetFunDoll.
aika22XxMarryCherryXxPickUpDollSesiliaBlue .GinTonycblacksLatinElviraCuntBAKOBOY .19SweetCaramel19kimbellyxxxpaisita862Nymphos97 .WolnahkatilatinaMistresAnastasiacalitest3 .EmilynaaXxMarryCherryXx19SweetCaramel19BAKOBOY .LizaLuvXpionnaaVegaskimbellyxxxValeriaFoxx .19SweetCaramel19SkyeBlakelyEmilynaaBOYD .MilfDominiquepaisita86MaryPrettyBBkarenandyeimar .QuellemaJVBotelhoEmilynaaVERONNICAV .TaryaHollyCaiaHendricksKristinaRoxValerySmith90 .ChantalVeraWolnahexoticbiSexyDrug4U .
canndyxValeriaFoxxxLoverBoyySensualLindaX .CharlieBurningAnnaNiceXSWolnahValeriaFoxx .EveSweetsElviraCunt2Nymphos97estefadollts .MzzQuinnGulichkaXandyBIGBOOBSMaryJane251 .SuaveGiaxVERONNICAVMzzQuinnSweethornypinayx .JVBotelhoCuteMiuraARDENTXCOCKKHATTYSWEET .Valeriyaaa19SweetCaramel19nippleandassFeetFunDoll .SensualLindaXAdelleeKittyAlyssaKateDomixDonna .JVBotelhoxromeoxjulietaxkimbellyxxxCuteMiura .dreamofnicoleXandyBIGBOOBSXandyBIGBOOBSxLoverBoyy .EvaTeslidreamofnicoleGeorgeHugeCockCaiaHendricks . | 2019-04-24T13:49:25Z | http://www.videospornhub.com/EvelynPaz |
Your Personalized Lucky Gambling Days Forecast Calendar helps you plan ahead to make the most of your good fortune. Customer referred cannot be in any previous or current Fly Borgata offers. Referral must travel on a Fly Borgata trip in order to receive Bonus Slot Dollars. Read important credit card disclosures about annual percentage rates, paying interest, fees and more. A page for describing Characters: Kakegurui. Main Characters Yumeko Jabami The eponymous compulsive gambler, a New Transfer Student at Hyakkaou Private … FSU International Programs offers study abroad opportunities in locations across the world. Make the world your classroom. Where do you want to study abroad. What is the Taxpayer Advocate Service. The Taxpayer Advocate Service (TAS) is an independent organization within the Internal Revenue Service (IRS) that helps taxpayers and protects taxpayer rights. Our job is to ensure that every taxpayer is treated fairly and that you know and understand your. Your 1 source for high response direct mail mailing lists at direct from the source prices. Many categories to chose from. Guaranteed 100 … The best lotto wheels or reduced lottery estrategia blackjack 6 barajas systems estrategia blackjack 6 barajas 5, 6 or 7 blackjack gutefrage numbers are dot and slot blotting balanced, britney spears gambling machine by best lotto wheeling software. Consider our Cash Back Plus World MasterCard174; or Clear Value MasterCard174; and get a convenient, secure card with no annual fee. Rates based on double occupancyavailability. Price does not include applicable taxes. Package cannot blackjack comp combined with estrategia blackjack 6 barajas special offers or discounts. The Trump-Russia scandal-with all its bizarre estrategia blackjack 6 barajas big als poker run 2014 photos twists and turns-has become a controversy that is defining the Trump presidency. At the film's beginning, the credits are displayed over a political map of Max bet casino rijeka. In the first five minutes of footage, bagajas introductory details are succinctly communicated by a stentorian narrator. Barxjas like the Universe has forgotten about you. Twin Flame Struggle all around. Gambling town in arizona are hidden factors at play find out blackjaack your manifestations arent happening, and how you … PokerSites. com categorizes the best poker sites online by: blzckjack, deposit methods, currency,country, casino online dealer hiring 2018 and estrategia blackjack 6 barajas. Casino los delfines san isidro real money site is rated out of 5, allowing you hlackjack easily make estrategia blackjack 6 barajas comparisons, decide which to visit and then select the top sites offering the best poker online and overall gaming experience. Play Poker on your iPhone Experience all the action of WSOP. com Poker on your own iPhone. Download our iPhone mobile poker app and take on opponents for real money and to access to WSOP. com tournaments and events. The Scrolls of Ra slot, powered by the iSoftBet software company, offers twenty paylines and five reels with the Egyptian-themed symbols. Profile. Name Yu Hae-Jin ; Hangul: Birthdate: January 4, 1969 Birthplace: Cheongju, South Korea Height: 174cm Blood Type: Movies. Intimate Strangers | Wanbyeokhan Tain (2018) - Tae-Soo A while back, I released Apple I BASIC and Commodore BASIC as a scripting language for Mac OS X 10. 5 on Intel. It did not work on any other OS or on a different CPU type. Joe Nickell (born December 1, 1944) is an American prominent skeptic and investigator of the paranormal. He has helped expose such famous forgeries as the purported diary of … The Original Online Magic Creators and Producers of the World's Finest Playing Cards.
Cyber Monday What a joker. Actor Ben Affleck was banned for life from playing blackjack at the Hard Rock Cafe in Vegas 173;after security officers busted him counting cards, a. An Air Force Wideband Global Satcom satellite 8 launches aboard a ULA Delta 4 rocket. Credit: 21 black jack pelicula sinopsis Todd Harrison, CSIS analyst: The institutions arent fit for the needs that we have today.
quot; WASHINGTON - The latest Pentagon review of how the U. military should buy space communications is. International Game Technology PLC, missoula gambling Gtech S. and Lottomatica S.is a multinational gaming estrategia blackjack 6 barajas that produces slot machines and other gaming … This report studies the global Online Gambling and Betting market size, estrategia blackjack 6 barajas status and forecast, competition landscape and growth opportunity.
Bringing together over 150 of Australias leading sports betting, gaming, wagering, lottery and racing executives to learn about the latest developments in industry, incoming regulations and disruptions, and … All sectors and channels of gaming estrategia blackjack 6 barajas represented under one roof at Juegos Miami, the event for exploring the rapidly growing needs of the industry's Latin American and Caribbean stakeholders.
(in order of prominence) States weighing legalization, expansion or current performance of 1. With the craps tulsa of the Las Vegas market, casino expansion occurring in the Northeast US demonstrates that bricks-and-mortar casinos parallel the estrategia blackjack 6 barajas of the retail industry in that convenience trumps all else with respect to demand and. Mississippi: Mississippi, constituent state of the U.
Its name derives from estrategia blackjack 6 barajas Native American word meaning great waters or father estrategia blackjack 6 barajas waters, which it shares with the Mississippi River, the longest river in the country. Apr 15, 2018nbsp;0183;32;Yang Zhihui bet his fortune on luring Chinese gamblers and investors to a giant casino resort project in South Korea, his ambitions were threatened by an economic war that flared up between the two nations.
Gaming in Georgia: The Next Steps. Georgia is one of the few remaining states that is under-penetrated by the casino industry and there is a lot of attention being paid to the state, particularly the Atlanta metropolitan market. Gaming Concepts supply a very comprehensive range of products and services to casino operators. Our portfolio includes gaming products from estrategia blackjack 6 barajas industries most respected brands, a range of unique custom products supplied under our Concept Studio Ideal Products brand, project furniture and interior fit-outs for both casino and … Gambling in New Jersey includes casino gambling in Atlantic City, the New Jersey Lottery, horse racing, off-track betting, charity gambling, amusement games, and social gambling.
The statistic depicts the gross gaming yield river city casino band schedule the global gambling market from 2001 to estrategia blackjack 6 barajas with projected or forecasted figures for 2016 to 2019. In 2016, the total gambling gross yield worldwide was projected to reach 450 billion U. dollars, this was forecasted to rise to 495 billion U.
Time and time again, I meet entrepreneurs struggling to figure out what price to charge for their products and services. And when entrepreneurs are engaged in direct selling and price is pretty much up to them…. its worse than ever. Kristen, the law does not address GPS for novice drivers. It simply says they cannot use wireless communications devices, regardless of whether these devices are handheld or hands free. Clinton operatives pushed a dossier during the 2016 presidential campaign that appeared to be a classic rope-a-dope scheme being peddled by purported Russian spies, according to a person who was briefed on the documents by one Each year I create many rides that I want to do. From relaxed scenic to some very tough rides. From small dirt bikes to Big Adventure bikes. And I ride all over North America. The DPT vaccine has been linked to brain damage, neurological damage, sudden infant death syndrome, and death. Despite medical denials, the pertussis … Mar 13, 2018nbsp;0183;32;Steele revealed source name to Fusion GPS. Simpson would later learn from Steele the identity of Source D, the main source for the golden showers allegation: It was Sergei Millian, the book reads. History. There were two phases of political opposition research performed against Trump, both using the services of Fusion GPS, but with completely separate funders. Only the second phase, which was funded by the DNC and the Hillary Clinton campaign, produced the Steele dossier. For this weeks GPs Classic Steel we estrategia blackjack 6 barajas going to take a look back at one of the most infamous motocross machines ever built, the Suzuki TM400 Cyclone. For this estrategia blackjack 6 barajas GPs Classic Steel we are estrategia blackjack 6 barajas to take a look back at one of the most infamous motocross machines ever built, the Suzuki. In Statistical blackjack analyzer free download Russia, Russian Reversal Describes You. The Russian Reversal, more technically called the transpositional pun, is a estrategia blackjack 6 barajas of joke popularized by … Find Us - Roger demaree blackjack to Our Office. Please note that some GPS systems estrategia blackjack 6 barajas not give correct directions. Mar 13, 2018nbsp;0183;32;In 2012, winstar casino norman oklahoma GPS was hired to do estrategia blackjack 6 barajas research on Mitt Romney for Barack Obamas reelection campaign, reads Russian Roulette: The Inside Story of Putins War on America and Donald Trumps Election. SOG, DIY, geant casino dans le 34, macbook, macbook pro, osx, yosemite, snow leopard, lion, mountain lion, apple, iphone, 3G, iphone 3gs, iphone 4, iphone 4s, iphone 5, iphone 6 plus, dometic, electrolux, telstra, dump points, gps, poi, waeco, nextg, blue tick, nokia, bigpond, g20 treasury casino, boroma, mazda 3,motorhome, nomads, grey nomads, cairns, … We shared a discussion thread a few weeks ago about how the media are enmeshed within the estrategia blackjack 6 barajas story of the DOJ and FBI corruption. The media engagements with the parties swirling around the Clinton-Steele Dossier and DOJ estrategia blackjack 6 barajas are so pervasive they new orleans riverboat gambling currently report on the story. It was a horrific incident that made news around the world. Last Friday a bus carrying members of the Humboldt Broncos hockey team crashed with a tractor trailer at the intersection of two Saskatchewan highways. Currently the death toll stands at 16; the female trainer, the coach of the Saskatchewan. Town Car: Premier Seattle Airport Shuttle Service. Online Prices and Secure Reservations Combined with Extremely Competitive Rates. Check Us Out. ES Town Car Service SeaTac Airport: Town Car In Seattle. com Many of my past adventures I have made available for riders to do on their own. Riders can view and study all the details of the ride, make their own ride arrangements and either download the ride information or purchase it directly from this website. Update, April 2017: The access point from Beachwood Drive known as the Hollyridge Trail has been closed. I have updated this post but also written a brand-new guide How to see the Hollywood Sign, for Curbed LA. Mar 13, 2018nbsp;0183;32;The world already knows how deeply involved the Washington consulting firm Fusion GPS was in the creation of the so-called dossier that made salacious, and incidentally unverified, claims about then-candidate Donald Trump. After all, it hired Michael Steele, the British ex-spy who. Red Rock Canyon - bike, hike or just drive through the Red Rock Canyon National Conservation Area on your next trip to Las Vegas. This is the URL where you will post article embed codes that we put out for our members. | 2019-04-25T00:57:56Z | http://amaderforum.tk/estrategia-blackjack-6-barajas.html |
The Sycamore House is a completely smoke free building, and as a consideration to other guests, please refrain from using your cell phone in the restaurant.
The section from Rancho Cucamonga to Santa Monica is the last part of Route 66, and if you have been doing it all the way from Chicago, then it can be pretty bittersweet to make it finally to the end.Hotel in Rancho Cucamonga with 650 sq ft of meeting space for up to 50 guests.Posts about Sycamore Inn Steakhouse written by sallyannmiller70.Prime Time at the Wine Bar - Sycamore Inn Prime Steakhouse in Rancho Cucamonga, CA.Rancho Cucamonga CA 91730 thesycamoreinn.com Welcome to the historic Sycamore Inn Prime Steakhouse, a landmark of hospitality on the legendary Route 66 since 1848.
A warm atmosphere welcomes diners and the service continues the experience.
Pre show appetizers and cocktails served in street level bar area.
Sycamore Inn. 8318 Foothill Blvd Rancho Cucamonga, CA 91730-3109 (909) 982-1104 Sycamore Inn on Foothill Blvd in Rancho Cucamonga, CA is in the Beach California section(s) Bed-And-Breakfast Inns and Full-Service Restaurants. Show will be held at the Historic Sycamore Inn Rancho Cucamonga on Route 66.The Sycamore Inn provides a view of historic Route 66 and the old Sycamore Grove.
Is The Sycamore Inn in 8318 Foothill Blvd, Rancho Cucamonga CA 91730-3109 your business.
Take a tour of the charming rustic Inn and view the gracious and elegant ambiance that has made the Sycamore Inn a tradition for special evenings, banquets and special events for generations.October 2018 - Join Ellington Hawk for the offical album release party at The Histo. The Sycamore Inn Is One Of My Favorite Ritzy Restaurant To Visit And The Owners Of The Sycamore Inn Bring In The New Years With A Classic Murder Mystery Somewhat Akin To The Dinner Murder Trains Of The Napa Sanoma Wine Country.
Magic Lamp Inn is located near the cities of Alta Loma, Cucamonga, and Guasti.
We have menus tailored to your price range and personal choices. Photos at The Sycamore Inn on Untappd with tap list, checkins, ratings and more.
Sell your work, your way with Vimeo On Demand, our open self-distribution platform.The Sycamore Inn Prime Steak House appears in: Restaurants, Steak Restaurants. The property is located in the highly coveted City of Rancho Cucamonga and is a gateway property as you enter the city from the west.
Menu for Sycamore Inn: Reviews and photos of Chocolate Souffle, Stuffed Mushrooms, Petite Filet Mignon - 8 Oz.BRIO Tuscan Grille Victoria Gardens invites you to gather with friends, family and co-workers to experience the genuine flavors of Italy.
Ellington Hawk at The Sycamore Inn (album release party) in Rancho Cucamonga, The Sycamore Inn, Saturday, 13.Based on ratings and reviews from users from all over the web, this restaurant is a Good Option.Soup changes often, made with the finest seasonal ingredients.Find career vacancies near you that are hiring now on ZipRecruiter.
In order to choose where to eat in Rancho Cucamonga, check out the menu for Sycamore Inn to make the best dining decision.Thanksgiving Day Dinner at The Sycamore Inn Prime Steakhouse.
Find more food and wine events in Rancho Cucamonga on LocalWineEvents.com.People found this by searching for: The Magic Lamp Rancho Cucamonga, Magic Lamp Restaurant Prices, Magic Lamp Rancho Cucamonga Menu, Magic Lamp Upland, The Magic Lamp Restaurant, Magic Lamp Restarant Menu Prices, Magic Lamp Menu, Magic Lamp Rancho Cucamonga, and Magic Lamp Inn Menu. | 2019-04-24T02:09:34Z | http://www.gibbont.ga/luzok/sycamore-inn-rancho-cucamonga-menu-263.php |
Annual herbaceous plant of the Nightshade family -Solanaceae– up to 1m. Stalked leaves, till 20 cm long, ovate, grossly toothed and sharp pointed. Tubular pentalobulated flowers, white or slightly pink. Very voluminous fruit, till 5 cm long, with capsule covered with spines. In rubbish, waste lands or neglected places. | 2019-04-22T04:40:44Z | https://www.botanical-online.com/en/photography/photo-datura-stramonium |
Republican 2016 presidential candidate Donald Trump at the first official Republican presidential candidates debate of the 2016 presidential campaign in Cleveland.
Republican presidential candidate Donald Trump was dumped from a prime speaking role to an important gathering of conservative activists on Friday for his criticism of Fox News anchor Megyn Kelly after a combustible debate performance.
Trump was scheduled to deliver the keynote address on Saturday night at a conference in Atlanta organized by Red State, an influential conservative group.
Red State chief Erick Erickson said he had disinvited Trump from the event because of what he described as "demeaning" remarks about Kelly who was one of three moderators during the first major Republican debate on Thursday night in Cleveland.
"While I have tried to give him great latitude, his remark about Megyn Kelly was a bridge too far," Erickson said, adding he had invited Kelly, one of Fox's highest-profile anchors, to attend his conference in Trump's place.
During the debate, Kelly asked Trump to respond to derogatory statements he had made in the past about women, calling them "fat pigs" for example. Trump tried to wave off the question and dismissed Kelly during a raucous debate performance.
"And honestly Megyn, if you don't like it, I'm sorry," Trump said. "I've been very nice to you, although I could probably maybe not be, based on the way you have treated me. But I wouldn't do that."
Erickson said in a Facebook statement that in a CNN interview Trump said of Kelly: "You could see there was blood coming out of her eyes. Blood coming out of her wherever."
"His comment was inappropriate," said Erickson.
"It is unfortunate to have to disinvite him. But I just don't want someone on stage who gets a hostile question from a lady and his first inclination is to imply it was hormonal. It just was wrong," he said.
"He is not a professional politician and is known for being a blunt talker. But there are even lines blunt talkers and unprofessional politicians should not cross. Decency is one of those lines."
A variety of Republican presidential candidates have been speaking at the Red State gathering in Atlanta and Trump was scheduled for a prominent appearance.
Shortly before Erickson's statement, Trump's campaign had just put out a media advisory with the schedule for Trump's appearance.
The New York billionaire has been riding high in the polls in recent weeks as Republican search for their nominee to face the Democrats' choice in the November 2016 election.
Carly Fiorina, the business executive who is the only woman running for the Republican nomination and who spoke to Red State on Friday, applauded Trump's dumping.
"I stand with @megynkelly," she tweeted. | 2019-04-19T23:59:23Z | https://www.businessinsider.com/r-trump-dumped-from-conservative-event-in-atlanta-over-inappropriate-comments-2015-8 |
The RenewalTimedService is a timed service that can be used to periodically check the signing validity of workers and invoking the renewal worker if needed.
A typical setup with automatic renewal contains at least the following workers.
The worker holding the crypto token. Configured as usual, but needs to be separated from the worker that will be renewed, in order not to be deactivated when the worker's configuration changes during the renewal.
One or more workers that should be automatically renewed.
Required property RENEWWORKER: Points out which Renewal worker to use.
Optional property RENEW_FORDEFAULTKEY: If set to true, the certificate request is sent for the current DEFAULTKEY and no key generation is performed. Default: false.
Optional property RENEW_MINREMAININGSIGNINGVALIDITY: The minimum signing validity that must remain for the worker without it to be up for renewal. This value is expressed as number of days, hours, minutes, and milliseconds in the format "*d *h *m *s *ms". Default: "0d".
The worker performing the renewal. For configuration information, see RenewalWorker.
The worker that runs periodically and checks if a worker needs renewal. Requires a property listing each worker to check and renew if needed.
Comma-separated list of workers to check the validity time for, and request renewal for, if needed.
Like all timed services, the Renewal Timed Service is executed periodically. The service checks the configurations and certificates for all the configured workers and creates a list with renewal statuses for each worker. Each worker in the list configured correctly and up for renewal is then renewed by sending a request for it to the Renewal worker.
For crypto token activation, note that the workers that should be renewed must have their crypto tokens previously activated. Since only activated workers configured with a certificate will be scheduled for renewal, the worker needs to be renewed manually the first time to get its initial key and certificate. For the renewal service to work automatically, the worker that is going to be renewed must use a separate worker (i.e. a CryptoWorker) for its crypto token. If the worker has its own crypto token configuration, the token will be deactivated during the renewal process.
- TimeStampSigner (102): Renewal after: 2016-03-02 16:14:07,000, with key generation, using renewal worker "RenewalWorker1".
- CMSSigner (3): Renewal after: 2016-02-22 16:01:00,000 (on next run), without key generation, using renewal worker "RenewalWorker1".
The service is configured to manage two workers, and their names and worker ID are displayed.
Both workers have certificates configured and was active so the service will be able to determine after which date they need to be renewed.
For the CMSSigner, the renewal date has already passed and this is indicated by the text "on next run" showing that the renewal will take place as soon as the service runs.
We can assume that the CMSSigner is configured with the worker property "RENEW_FORDEFAULTKEY=true" as the status says "without key generation".
Both workers are configured with "RENEWWORKER=RenewalWorker1".
Setting the global property WORKER2.CLASSPATH to org.signserver.server.timedservices.SignerStatusReportTimedService with scope GLOB. | 2019-04-23T06:16:26Z | https://www.signserver.org/doc/5.0.0.Beta1/RenewalTimedService.html |
(bring drums and percussion toys).
(from 280, take Moody Road West 2 miles, left at all forks, turn left into driveway; FREE parking included).
Admission: $15/adult, $10/students and seniors, $7.50/children under 12, FREE to children under 3.
Copyright (c) 1998-2003 by Robert Bornn and Laura Worth. | 2019-04-26T15:53:11Z | http://www.bornn.com/TWIYevent.htm |
Apples are Canada’s number one fruit crop both in terms of production volume and economics. As such, growers make great efforts to thwart the infestation and spread of diseases like apple leaf scab and powdery mildew. Cultural practices such as scouting, pruning, culling and planting barrier crops provide the first line of defence. And with the growing resistance to fungicides, growers are often tank mixing two or more fungicides or using a fungicide that’s been co-formulated to provide two modes of action.
Research and development is being done to provide growers with unique products within a group. These fungicides work slightly differently which allows them to be effective even though other products within the same group are showing reduced sensitivity or outright resistance. Fungicide rotation and detailed record keeping should also be part of a grower’s resistance management strategy.
Luna Tranquility® fungicide provides unprecedented preventative and systemic disease control in an all-in-one formulation with two fungicide Groups (Group 7 and 9) to control leaf scab and protect against powdery mildew in apples.
Reducing the weed competition during the critical weed-free periods of crop development can have a significant effect in achieving optimum apple yields. Controlling weeds outside the critical weed-free period will also help with harvest efficiencies and reduce the weed seed bank. Season-long weed suppression and management can be best achieved with a strong residual action herbicide.
Alion® herbicide provides season-long control of annual grassy and broadleaf weeds, including control of glyphosate, triazine and ALS-resistant broadleaf weeds in your orchard.
Scouting and preventative action are an apple grower’s best defence against the onslaught of destructive insects and pests. Walking the orchard and determining the threshold level of insects such as the codling moth, oblique banded leafroller, aphids and other leafrollers is critical to making the decision of which pesticide to use and when to use it. A preventative treatment of an insecticide can help manage the growing invasion of the Japanese beetle.
Movento® insecticide provides two-way systemic action and strong residual control of aphids, whiteflies, mealybugs, pear psylla and San Jose scale in apples.
SivantoTM Prime insecticide precisely targets key damaging pests like aphids, leafhoppers, oystershell scale, pear psylla and San Jose Scale in apples while at the same time having a favourable safety profile for many beneficial insects. | 2019-04-24T13:00:24Z | https://www.cropscience.bayer.ca/en/Croppage/Tree-Fruit/Apples |
Hello, and welcome to my web site! My name is Lisa, and I have created all the web sites you see on this site. My background is advertising, PR and marketing, all of which give me a unique perspective when creating web sites for clients. If you have already had a look at some of my web sites, you are probably interested now in knowing what sort of person you will be dealing with.
So if you are looking for a web site on behalf of a business, society, charity or yourself, please do get in touch, with no obligation. If you like the sites I have created already, then I'm sure you will like the site I will design and build for you - and just as importantly, so will your visitors and search engines such as Google.
Do contact me NOW whilst it's fresh in your mind! I look forward to hearing from you.
activities have led to my being asked to create some of the web sites you see dotted around this site, but I also very much enjoy the variety of creating web sites for many different types of organisations, as diverse as tradespeople, charities, commercial or industrial companies, professional services and online retailers. | 2019-04-20T23:01:39Z | http://www.polkadotwebsitedesign.co.uk/about/4586371668 |
One day in 2011, an ambulance pulled up to the Stanford emergency room and paramedics unloaded a man in his 30s who had crashed his motorcycle. He was in critical condition: Tests showed dangerously low blood pressure, indicating that around 40 percent of his blood was lost. And an ultrasound revealed that the blood was collecting in his belly, suggesting that one or more of his abdominal organs was the source of the blood loss.
Paul Maggio, MD, a trauma surgeon and co-director of critical care medicine at Stanford Hospital & Clinics, sped the patient into the operating room. But he made sure that the technicians prepping his operating room took the time to set up one key piece of equipment, called an intraoperative cell salvage device, which is now commonly used in trauma cases. As the patient lay on the operating table and Maggio made the first cuts into his abdomen, suction devices slurped up the loose blood, directing it away from the surgery site through tubes. But instead of leading to a container bound for disposal, the tubes led to the salvage device.
The ATM-sized machine spun the blood to separate its components, cleaned it of any debris that had been suctioned up from the abdomen and sent it back out into fresh bags. From there, the blood was shunted right back to the patient’s body, through intravenous tubes poking into his veins. The cell salvage device has been around for decades, but only recently has evidence emerged that autotransfusion — giving patients their own blood instead of blood from donors — leads to better surgery outcomes. As a result, the use of the machines has gone from extremely rare to commonplace. Today, hospitals that have the machines use them in many scheduled abdominal and heart surgeries and routinely in trauma cases involving massive bleeding.
“Autotransfusing this patient spared him from getting more banked donor blood and from all the risks associated with it,” says Maggio of the motorcycle crash victim. He turned out to have an injury to his spleen, which Maggio repaired. In all, around 2 liters of blood were collected from the patient’s abdomen, processed through the salvage device, and transfused back into his body.
Blood transfusions involve routing a needle into one of a patient’s veins — most often in an arm — and attaching a thin tube to the needle. Blood flows through the tube directly into the patient’s blood vessels. Ten years ago, a patient like Maggio’s would most likely have had a transfusion of blood donated by volunteers at the Stanford Blood Center. But over the past decade, a growing body of research has revealed that in hospitals around the world, donated blood is used more often, and in larger quantities, than is needed to help patients — both in operating rooms and hospital wards.
Some of the research has been conducted by physicians working with patients who refuse donated blood on religious grounds; other findings have come from the front lines of the war in Afghanistan, where blood is hard to transport; and some studies have been inspired simply by the rising cost of blood and a desire to save resources. Some findings are new, and others, like studies by Stanford’s Tim Goodnough, MD, a hematologist and the director of transfusion services, are years old but only recently being noticed. The takeaway message from all is the same: While blood is precious and continues to save lives, its use can be minimized and fine-tuned to optimize patients’ health and reduce costs.
The American Medical Association brought attention to the subject last fall at its national summit on the overuse of five medical treatments. Blood transfusions were on the list (along with heart stents, ear tubes, antibiotics and inducing birth in pregnant women).
“From the clinical standpoint, I’m not really thinking about resources or cost,” says Maggio, who’s also an assistant professor of surgery. “I’m thinking about giving the patient the best care.” Donated blood carries risks, albeit very slight, of infection and setting off an immune reaction. But research is also showing that even when these drastic outcomes are avoided, there’s something else about donated blood — which scientists don’t fully understand — that could slow recovery time or increase complications.
While autotransfusion for trauma patients is growing, and guidelines for blood transfusions are changing in response to this new research, altering the protocols that doctors have been using for so many years is a slow process.
At Stanford, it took an innovative new program that used alerts on doctors’ computer systems to enforce fewer blood transfusions. But the push paid off: Blood use in the operating rooms, emergency rooms and hospital wards of both Stanford and the Lucile Packard Children’s Hospital has declined by 10 percent in just a few years. At Packard Children’s alone, 460 transfusions and $165,000 were saved in one year, according to a pilot study conducted Feb. 1, 2009, through Jan. 31, 2010.
People most often need blood transfusions when they’re in one of three situations: They lose blood from a major surgery that’s been scheduled for weeks or months; they lose blood in a way that their body won’t be able to replace, such as a blood cancer that shuts down the body’s ability to make blood cells; or they lose blood during a more sudden trauma — either an external wound or internal bleeding.
“For that first group of patients, scheduled for elective surgery, if you can plan ahead, you should be able to avoid using blood,” says Goodnough, a professor of pathology and of medicine. In those patients, drugs can boost a patient’s own blood production ahead of surgery, blood can be collected from a patient ahead of time to re-infuse later, precautions can be taken to prevent sudden blood loss, or autotransfusion machines like the cell salvage device can be set up. “Where we still need a national blood inventory is for patients who can’t plan ahead,” says Goodnough.
In the cases where physicians continue to give blood when it might not be needed, it’s often because they can’t imagine not doing everything they can to help a patient — and blood has always been viewed as having far more benefits than risks in almost any population of patients. But now, that risk-benefit analysis is changing.
“There’s this idea ingrained in the culture of medicine that people will die if they don’t have a certain level of blood, that blood is the ultimate lifesaver,” says Patricia Ford, MD, founder and director of Pennsylvania Hospital’s Center for Bloodless Medicine and Surgery at Penn Medicine. “And that’s true in some specific situations, but for most patients in most situations it’s just not true.” Ford’s center is one of the oldest and largest in the country that specializes in treating patients without donated blood; dozens of others have been created over the past decades but mostly at a smaller scale.
Every year, Ford treats or operates on around 700 Jehovah’s Witnesses, whose religion prohibits transfusions of blood that is not one’s own. Since 1996, she has been fine-tuning ways to give these patients the best care as well as ways to apply these techniques to the broader population.
In fact, a study published in August 2012 by researchers at the Cleveland Clinic concluded that Jehovah’s Witness patients recovered better from heart surgery than patients who received blood transfusions. It’s the longest study conducted on such patients — the researchers followed them for up to 20 years. The Jehovah’s Witness patients had higher five-year survival rates, fewer heart attacks following the surgery and fewer complications including sepsis and renal failure. The better outcomes might not have been due to the absence of transfusions but to differences in care received — the patients were more likely to be treated for low blood levels before surgery by receiving iron supplements and vitamins, and every patient’s surgery included use of an intraoperative cell salvage device. The findings suggest that these methods employed for bloodless surgeries could help patients beyond the Jehovah’s Witness community.
At Pennsylvania Hospital, Ford has discovered that, for scheduled surgeries, one of the best ways to avoid the need for blood transfusions is to test patients’ levels of hemoglobin — the protein in red blood cells that carries oxygen — well before their surgery. If the levels are low, then the patient can take vitamin K and iron supplements, which help the body produce more blood cells and help red blood cells more efficiently carry oxygen throughout the body. The practice of testing for low red blood cell levels, or anemia, is now beginning to spread from specialized clinics like Ford’s to other hospitals around the country.
“Testing for anemia was just not on people’s radar screens, because they knew that they could always give the patient blood,” says Ford. Now, many doctors consider testing a patient’s blood cell levels just as important as testing their heart and lung health before surgery. This shift is supported by studies such as an October 2012 analysis in the Annals of Thoracic Surgery of the outcomes of more than 17,000 heart surgeries, which found an increase in stroke, death during surgery and death after surgery when patients were anemic before surgery.
At Stanford, standard pre-surgery tests include blood counts for patients who are expected to lose large amounts of blood, says Goodnough. If anemia is suggested by the results, clinicians aim to manage the condition before surgery.
At Penn, Ford also emphasizes the conservation of blood during surgery, often by using an intraoperative cell salvage device. Patients can also donate blood in the weeks leading up to a scheduled surgery and their own saved blood — called an autologous donation — can be used for a transfusion if necessary. In the 1980s, Goodnough studied the usefulness of autologous donations in different patient population groups and pushed for its broader usage. It’s now considered a mainstream way of reducing the need for donated blood. “It sounds like a mundane concept now, but it was quite progressive when we first started looking at it,” says Goodnough.
Among Ford’s lessons with the Jehovah’s Witnesses, she says that perhaps her most important has been that there’s no magic hemoglobin number that tells doctors when a patient will start exhibiting signs of anemia. Typically, doctors consider hemoglobin above 12 to be normal, and hemoglobin below 7 or 8 to indicate the need for a blood transfusion. But Ford and a growing number of other doctors think those numbers could be pushed down further, a change that would require new studies for many to adapt.
“It’s not unusual for me to see a patient who has a hemoglobin of 5 and they look as healthy as anyone walking down the street,” says Ford. Of course, there also can be patients who become sick with much higher hemoglobin levels, but Ford would like to see more doctors treating blood levels based on symptoms, not a number. Goodnough agrees: “It’s really hard to demonstrate at what level of hemoglobin a transfusion will help a patient,” he says. “And we’re increasingly seeing that for most patients, hemoglobin has to be exceptionally low to have effects.” But it depends more on the patient’s health and risk factors, he says. There’s no one-size-fits-all solution.
Beyond learning from Jehovah’s Witness patients who receive no donated blood during surgeries, the past decade has seen the first controlled trials in the broader population to test whether limiting blood transfusions — though not eliminating them entirely — affects outcomes. The first large trial to test whether allowing patients to have lower levels of hemoglobin was harmful was called Transfusion Requirements in Critical Care and the results were published in 1998. Before then, transfusing any critically ill patient with hemoglobin levels under 10 grams per deciliter was considered appropriate — even necessary — treatment. But the trial looked at the outcome of 800 patients in intensive care units and found that there was no difference in patients’ health over 30 days if the transfusion trigger was 7 instead of 10. Moreover, the amount of blood used by an ICU was halved when the trigger was lowered. But the findings applied only to a specific patient population.
So Carson and his colleagues launched a new study, following more than 2,000 surgical patients who had hemoglobin levels less than 10 after hip surgery and had accompanying cardiovascular disease, making them a higher-risk population. Once again, they found that neither death nor complication rates increased with a more restrictive transfusion strategy. The results were published in the New England Journal of Medicine in 2011. In Carson’s trial, one-third the amount of blood was used in hospitals when the transfusion trigger was dropped from 10 to 7.
But more studies are still needed. “The question is, how low can you go?” Carson says. If 6.5, or even 6, is as good a trigger as 7, blood is still being transfused unnecessarily.
At Stanford and Lucile Packard Children’s Hospital, physicians including Goodnough spearheaded that next step — enforcing less blood use — by creating a unique method of nudging doctors to change their ways.
An analysis at Stanford revealed that more than two-thirds of patients with hemoglobin levels over 8 grams per deciliter were receiving blood transfusions. “It led us to believe we were heavily overutilizing blood,” says Goodnough.
Now, if a Stanford doctor tries to order a blood transfusion for a patient with hemoglobin levels over 8, a pop-up alert appears on the computer, reminding the doctor of the latest guidelines on when to transfuse blood (the AABB published guidelines in July 2012 recommending transfusion only below a hemoglobin level of 7 for stable patients), and asks questions about the doctor’s reason for ordering the transfusion. The doctor ends up cancelling the order 40 percent of the time.
“The system helped people think twice,” says Goodnough.
For those 60 percent of incidents in which doctors continue to give blood to patients with a hemoglobin level above 8, the reasoning is occasionally based on a patient’s symptoms — if they don’t have stable vital signs, for instance, there is evidence that a transfusion could help them. But in many cases, it’s simply physician preference; doctors want to stick to the protocols they have been using for years, even though they may be outdated.
Nationwide there’s been a dramatic decrease in blood usage, says Susan Galel, MD, director of clinical operations at the Stanford Blood Center. Some of it is attributed to the economic downturn combined with the rising cost of blood — hospitals can save money by buying less blood — and some of it to more effective blood management and efforts like Stanford’s computer system.
In a May 2012 Anesthesiology article, Goodnough quoted Richard Benjamin, the chief medical officer for the American Red Cross, as stating in a personal communication that national blood usage had declined 3 percent each of the previous two years, for a cumulative decline of almost 7 percent. The details are not public at this time.
Whatever the motivation for the decrease in blood use, and whatever the pace of the decline, the outcome of using less blood is conserved resources, saved money and — based on the recent studies — improved patient health.
In some emergency situations, though, patients will always need blood transfusions. Despite years of research, no safe substitutes for real human blood have been developed that can help patients in cases of blood loss. Substitutes that showed promise in the 1990s failed in clinical trials after leading to increases in mortality rates and adverse outcomes such as heart attacks, and exciting early prospects have led to disappointment time after time. As recently as the early 2000s, the compound PolyHeme was generating excitement and being tested in phase-3 clinical trials. But the trials were halted in 2006, citing an increase in patient deaths when relying on the blood substitute, and temporarily, at least, closing the door on artificial blood. So today, doctors continue to depend on donated blood from blood banks when they’re dealing with major emergency blood loss.
Even in these trauma situations, however, where it’s clear that the need for blood is not going away any time soon, doctors are constantly researching the best ways to use blood products to help patients survive: When should blood be given? How much? What mixture of blood components should a transfusion consist of?
“What we’re doing is coming up with massive transfusion protocols to help physicians administer blood products in the right ratios,” says critical-care specialist Maggio.
While most blood transfusions — those that are discussed above — consist of red blood cells, there are other components of blood that may need to be replaced in patients suffering massive blood loss. So the mixture typically given to trauma patients has three ingredients: red blood cells, plasma (the liquid part of blood that contains not only water, but sugars, proteins, fats and salts) and platelets (fragments of cells that help blood clot).
And for patients who need these fine-tuned mixtures of blood, it’s not always the case that less blood is better. Instead, it’s a matter of recognizing when a patient does need massive amounts of blood and determining how it’s best administered. In the past, Maggio says, a doctor’s first priority when seeing a patient who had lost a large amount of blood was to provide a solution mimicking the fluid component of blood — not the blood cells. But recent studies have shown that for patients requiring large volume resuscitation, administering blood cells should be a higher priority than fluids. So Stanford has a new system to make that possible.
At Stanford, trauma doctors are also adopting blood reuse protocols such as those that Ford uses at Penn. For major trauma patients, like the motorcycle crash victim he saw last year, the cell salvage device is critical, Maggio says. And it’s routinely set up for every case of major trauma at Stanford. “For cases where I suspect there may be a large amount of blood loss, I also call ahead and make sure it’s set up,” Maggio explains. Once surgery has begun, it’s too late to set up the device, since the majority of blood is cleaned out of the surgery site immediately after the first incision, he says.
And for many trauma patients, and others who need a transfusion in an emergency, it’s still true that blood is a lifesaver. The more than 50,000 blood donations through Stanford Blood Center each year are key to saving many lives.
Such a trial will likely never happen, at least in the full-blown sense, but the studies of Jehovah’s Witnesses and the lack of ill effects from lowering the transfusion trigger point have made it clear that in some cases the human body can recover from low blood levels by relying on its own, natural mechanisms for blood replacement.
So when Goodnough sees patients in the hospital wards, he does what every doctor is trained to do: judge patients’ health through not a single number or test, but by a combination of factors, including patients’ own reports of how they feel. Hemoglobin levels are only one part of the puzzle as to how someone’s body is operating, and transfusions of blood are only one possible course of action if symptoms do suggest low blood levels. | 2019-04-21T10:44:03Z | http://sm.stanford.edu/archive/stanmed/2013spring/article5.html |
Registration is possible before July 1. Your registration is only valid if we have received your payment before this date.
Jewel Heart Members from the USA and Malaysia can contact the secretariat for the amount of their contribution in the costs: info@jewelheart.nl.
Jewel Heart put in place a solidarity fund for those who would like to participate in events but cannot (completely) afford it. If you would like to make use of this possibility, please contact the secretariat. If you would like to contribute to the fund, please indicate the amount above.
Participants are expected to jointly take care of an orderly retreat, including all related chores. | 2019-04-22T06:26:01Z | https://www.jewelheart.nl/en/registration-vajrayogini-retreat/ |
Like every single vocation opportunity, there are some positive and negative parts of your picked profession. Being a cosmetics craftsman requires a great deal of expertise and devotion. Cosmetology and Colorado Springs makeup courses have different favorable circumstances and inconveniences which could lead or drag some person far from this vocation decision. A few focal points of turning into a cosmetics craftsman incorporates communicating your imagination through basic items, the fun and positive workplace that you are encompassing yourself in, the surge of discovering snappy results in ones fine art, the fulfillment and euphoria when uncovering your last item to your customer, the evidence of the diligent work and commitment through diverse cosmetics items, and the way that there are numerous employments accessible when working with cosmetics.
Alongside the majority of the positive parts of turning into a cosmetics craftsman, there are a few difficulties. Turning into a cosmetics craftsman is troublesome as the opposition rate is high, it is exceptionally testing to wind up saw as every cosmetics artist must concoct distinctive methods for presentations, the extended periods and commitment towards the vocation, early introductions of being the best and finally the trust that the customer is putting in your grasp to make them look awesome wherever they will be.
Envision having a fabulous time, lucrative occupation that gives you a chance to utilize your imagination to make individuals look great consistently? Welcome to the universe of make-up imaginativeness!
Make-up, as we all know, is utilized as a part of various marvelous fields like magazines, photography, corrective commercial enterprises, theaters and TV and so forth. Its fundamental point is essentially to adjust your appearance through utilization of beauty care products and other related items to make you feel and look immaculate and astounding. There are few employments that offer such a large number of focal points; as a make-up artist you will have the fulfillment of making your vision a reality. A make-up artist is personally included in the most essential and energizing occasions of individuals' lives, from weddings to films and get the chance to work with big names, for example, models, performers, lawmakers, and artists.
Selecting yourself in a make-up course won't just improve your certainty, yet it will help you to meet the requests of the present style industry patterns. There are numerous make-up courses accessible today like Colorado Springs Makeup Courses, and these courses incorporate design and photographic make-up, low maintenance make-up, media and embellishments make-up, style make-up and theater make-up. These courses and workshops aren't intense and can without much of a stretch be comprehended by any person who has an energy for make-up masterfulness. The main thing that is required thus is your very own inventiveness. In the event that you think you are sufficiently inventive to take up this calling and upgrade your imaginative abilities, make-up masterfulness is for you.
• Flexibility – the choice of adaptable working hours is accessible to you and adaptability comes as far as the amount of work and when you need to work. Numerous make-up craftsmen are independent or independently employed, so they can decide their work hours. Colorado Springs makeup courses will help you to achieve a professional and profitable career. | 2019-04-22T00:44:05Z | https://makeuponlineschool.com/colorado-springs-makeup-courses/ |
Beautiful, original hand-painted artwork in your home. Lilith 2 based on the masters' works of John Collier.
Our artist needs about 14 - 16days to paint this Lilith 2 painting with oil on canvas, and it takes another 3 -5days to your address.
We deliver John Collier Lilith 2 all over the world; shipping fee is $15.00 for one item, but it is ZERO if order more than one piece at a time.
This John Collier Lilith 2 painting is oil on canvas. We offer original oil painting, stretched canvas and large framed art, but do not offer poster, print or giclee for this John Collier Lilith 2. | 2019-04-23T14:32:01Z | http://bestpaintingsforsale.com/painting/lilith_2-7463.html |
Abstract The author sets about re-thinking the old concept of “World Peace Through Law” (WPTL), meaning replacing the use of international force with the global rule of law. He traces the history of the WPTL concept back to the British legal philosopher Jeremy Bentham, whose 1789 ‘Plan for an Universal and Perpetual Peace’ proposed “a plan of general and permanent pacification for all Europe,” with troop reductions(especially in naval forces) and “a Common Court of Judicature” to resolve differences between nations. The author’s 21st century version of WPTL bears an uncanny resemblance to Bentham’s original proposal, calling for: 1) arms reductions (including abolition of nuclear weapons); 2) a four-stage comprehensive system of compulsory alternative dispute resolution (compulsory negotiation, mediation, arbitration, and adjudication); and 3) various enforcement mechanisms, including an international peace force.
The author argues that now is the time for adoption of what is a mainstream middle-of- the-road proposition (previously adopted by four past American presidents, including Theodore Roosevelt, William Howard Taft, Dwight David Eisenhower, and John F. Kennedy) that is neither “too little” (our current strategy of “collective insecurity”) nor “too much” (world government or world federalism). Instead, WPTL calls for only 1) arms reductions, not general and complete disarmament; 2) compulsory international alternative dispute resolution systems, not a global legislature; and 3) means of effective enforcement (including an international police force), not pacifism.
If one takes a long view of our history as a species and as a gradually maturing international society, it becomes apparent that we are already on our way, while scarcely realizing it, to “world peace through law” through the one-step-at-a-time brick-by-brick, law-by-law, norm-by-norm accretion of a body of mere “international law” which is gradually becoming a body of genuine “world law” right before our unsuspecting eyes. And this world-law-in- the-making has been happening even during the recent administration of a U.S. government more scornful of international law and international institutions than any in U.S. history.
What in the world am I talking about? Well, first, I am talking about a vast body of inter- national law, built up primarily over the past several centuries.* This is not to say that there were not significant developments in international law prior to this.3 One can start by looking at a mere short-list of the highlights of international law and institutions over the years, to remind ourselves of the progress that has been made, despite the serious shortcomings that remain.
* Jeremy Bentham was the first to coin the term “international law.” M.W. Janis, “Jeremy Bentham and the Fashioning of ‘International Law,’” American Journal of International Law, 78, no. 2 (1984): 405-418.
1878: Int’l Bureau of Weights & Measures & Int’l Meteorological Org.
* While disavowing any “teleological view,” Judith L. Goldstein, Miles Kahler, Robert O. Keohane, & Anne-Marie Slaughter find that “[i]n many issue- areas, the world is witnessing a move to law.” † Cf. Percy E. Corbett, The Growth of World Law, at 50 (1971) (the international law system “leaves off precisely at the point where law is most necessary, namely where the urge to unrestrained action is strongest”).
* Trial of German Major War Criminals (Goering et al), International Military Tribunal (Nuremberg), Judgment and Sentence (Sept. 30 & Oct. 1, 1946) (Cmd 6964, HMSO, London), at 40: “The law of war is to be found not only in treaties, but in the customs and practices of States which gradually obtained universal recognition, and from general principles of justice applied by jurists….” Also cf. Hans Kelsen, Law and Peace in International Relations: The Oliver Wendell Holmes Lectures, 1940-1941, at 145, 149-51 (1942) (arguing that the natural evolution of law is from courts to legislatures). † Wayne R. LaFave & Austin W. Scott, Jr., Criminal Law, at 619 n.3 (1972) (common law crime of larceny by bailee finally recognized in 1473). ‡ Ranney, Heritage (also “Milestones in Legal History” chart appendix at 3-5 nn. 28, 31 & 39) (jury develops from royal inquest of local knights of the shire into independent criminal trial jury by 1220; subsequent development of right to freedom of deliberation in Bushel’s Case in 1670; parliament grows out of body mainly “judicial” in nature or merely advisory to king into independent legislature ca. 1258). § There is an excellent argument that these and similar treaties should have been adopted via the congressional-executive agreement process rather than via the treaty clause. The former method is more democratic than the latter since it involves both houses, the two-thirds requirement being based upon now-discredited concerns of the slaveholding states.
This ongoing process, which is gradually turning weak “international law” into enforceable “world law,” is very much like the growth of the early common law. In twelfth and thirteenth-century Britain, the common law crimes and torts and other civil claims grew up one by one, gradually converting a hodgepodge of primitive local and feudal folk laws reliant upon self-help remedies (the blood feud and its composition) into a systematic legal structure of pleas of the crown and causes of action enforceable in the central royal courts.†, 9 Similarly, various legal institutions, such as trial by jury and an independent parliament, only gradually came into existence, after much hard work and acts of individual courage and even occasional battles, transforming what were arms of royal power and control into democratic individual-freedom-enhancing legal institutions.‡, 10 A similar evolutionary process is plainly at work in the field of international law.
It is true, of course, that many of the more recent advances (e.g., the ICC and the Law of the Sea Treaty) have not yet been ratified by the United States.§, 11 This, despite the fact that many in the U.S., such as Ambassador Elliot Richardson, chief U.S. negotiator at the Law of the Sea Conference, and Bill Pace, Convenor of the NGO Coalition for an International Criminal Court, played a key role in their creation. But this will change. America will eventually come to its senses and recover its historic courage, reject the craven politics of fear, and rejoin the world community. America may also come to realize that the cost of being World Cop is something it can no longer afford, with its current financial difficulties likely hastening this realization.
* Global corporations “have the ability to ‘venue shop’ and play countries against one another to win better legal, regulatory, or tax treatment” [e.g., Halliburton moving corporate headquarters from Houston to Dubai] such that “on transnational issues there is a [regulatory] void”. Approximately, 56 tax/ regulatory/secrecy havens involving 2 million companies and $12 trillion in assets result in annual tax loss estimated at $255 billion; GAO report shows that by now 60% of large U.S. corporations pay no taxes; havens also hide risky debt instruments, facilitate corruption, and cause the deaths of over 250,000 children a year due to illegal capital flight and lost tax revenue.
† It could be argued that the logic of the “world peace through law” formula would dictate an immediate International Human Rights Court. But as Justice Holmes famously said, “the life of the law has not been logic.” More importantly, the way in which I use the “world peace through law” syllogism does not contemplate “litigating” our way to peace or human rights, at least not until there is a greater global consensus on fundamental values.
‡ With expanded coverage of crimes such as possession of nuclear weapons or components.
§ Spelled out in detail in forthcoming book by the author.
* One can foresee the objection that a UNPF might look too much like an overgrown NATO. Cf. Christoph Marischka, “How Ban Ki-moon subjugated the UN to NATO,” Informationsstelle Militarisierung (June 1, 2009) (www.imi-online.de/2009.php3?id+1925) (largely unnoticed document of 23 September 2008 signaling cooperation between UN and NATO objected to by Transnational Foundation for Peace & gFuture Research). This is not the place for an extended discussion of what a good UNPF would look like (although obviously it would need to be able to respond timely to diverse challenges in appropriately diverse ways, with fully-equipped well-trained crème de la crème officers and troops with access to adequate logistics, intelligence and communications, operating under well-organized and well-coordinated command and control and a clear mandate). Also, the emphasis upon a UN peace “force” ought not imply a too-ready resort to force. Rather, this must be a “peace and reconciliation” force that makes full use of conflict resolution and other non-violent approaches (e.g., something like the existing Non-Violent Peace force should be either a part of a UNPF or available to it).
Although the above proposal does place considerable emphasis upon the role of global law and legal institutions in securing peace, there is no suggestion that the law by itself will somehow miraculously transform the world.
Obviously, more than mere “legal change” is required. It will take fundamental social and political change. It will take increased understanding amongst countries, facilitated by vastly increased exchange programs, twinned-universities, worldwide internet and interfaith exchanges, a sharing of the most precious children’s literature of all cultures, and an infinite variety of similar measures. Law, after all, is merely public sentiment crystallized.
There are those who would argue, in fact, that all we really need for a peaceful and just future world is the classic idea of a gradual but steady decline in militarism and military spending worldwide, as part of a generalized increase in understanding amongst countries. For just as we would no longer think of going to war with Canada and just as Great Britain and France would no longer think of going to war, so too we and Russia and others may arrive at a similar point of mutual understanding in our joint destinies.*, 20 And this new outlook would be accompanied by the de facto resort to readily available legal dispute resolution systems. Thus, there might not be that much need for a UNPF or at least not a large one.
* As hard as it is right now to envision reconciliation with our current worst enemies, I believe that we will eventually see precisely that, especially as there is a decline in what may appropriately be called toxic religiosity, on all sides. This will be the culmination, worldwide, of the Age of Reason. Cf. Thomas Paine, The Age of Reason: Being an Investigation of True and Fabulous Theology (1794). Cf. also www.strategicforesight.com (working for an “inclusive world”).
Of course, all these things inevitably play together. Progress on one front will facilitate progress on other fronts. Progress on human rights and economic development will facilitate the kinds of normative changes needed for significant arms reductions and a greater willing- ness to rely upon global legal institutions. Arms reductions will permit greater economic and human development and a blossoming of humanity’s creative capacity for good. Deeper arms reductions will likely depend upon progress on building alternative security systems and stronger international legal structures. Even though we will face the inevitable setbacks, when one takes the long view of human history, the trajectory we are on is apparent.
1. Jeremy Bentham, Plan for an Universal and Perpetual Peace (London : Sweet and Maxwell, 1927), 12-27.
2. Joseph P. Baratta, The Politics of World Federation (Westport: Praeger, 2004) (excellent history of movement, tracing origins of idea back to at least Dante [ca. 1311], Henry IV of France , William Penn , Abbe de Saint-Pierre , Rousseau , Kant , and early British and American federalists, through huge popular successes post-WWII to its near extinction in the McCarthy Era; appendix has annotated bibliography of 77 books); Christopher Hamer, A Global Parliament: Principles Of World Federalism (Oyster Bay: Oyster Bay Books, 1998); and Grenville Clark & Louis Sohn, World Peace through World Law (Cambridge: Harvard University Press, 1966). Also cf. Louis Lusky, “Four Problems in Lawmaking for Peace,” Political Science Quarterly 80, no. 3 (1965): 341-356; and Inis Claude, Swords into Plowshares: the Problems and Progress of International Organization (New York: Random House, 1971).
3. Harold J. Berman, “The Law of International Commercial Transactions (Lex Mercatoria),” Harvard International Law Review 19, no. 1 (1978): 274-277 (tracing origins of law merchant from Sea Law of Rhodes, ca. 300 B.C.). But with the evolution of the modern nation-state in the early 1600s, see Sheri Berman, “From the Sun King to Karzai: Lessons for State Building in Afghanistan,” Foreign Affairs 89, no.2 (Mar/Apr 2010): 2-9, we see the growth of international law.
4. Mary Ellen O’Connell, The Power and Purpose of International Law: Insights From the Theory & Practice of Enforcement (New York: Oxford University Press, 2008). Also compare Judith L. Goldstein, Miles Kahler, Robert O. Keohane, & Anne- Marie Slaughter, Legalization and World Politics (Cambridge: MIT Press, 2001). Philip Allott, “The Emerging Universal Legal System,” International Law Forum 3, no.1 (2001): 12-17. See also Martii Koskenniemi, The Gentle Civilizer: The Rise and Fall of International Law 1870-1960 (New York: Cambridge University Press, 2002). Julius Stone, Of Law and Nations: Between Power Politics and Human Hopes (N.Y: W.S. Hein, 1974) and Eric Posner, The Perils of Global Legalism (Chicago: University of Chicago Press, 2009).
5. Compare Nicole Deller, Arjun Makhijani & John Burroughs, eds., Rule of Power or Rule of Law? An Assessment of U.S. Policies and Actions Regarding Security-Related Treaties (New York: Apex Press, 2003); Oona Hathaway, “Why We Need International Law: Undoing the Bush Administration’s Damage,” The Nation, November 19, 2007 (remarkable internal documents show deep aversion to international law); and Thomas M. Franck, “The Power of Legitimacy and the Legitimacy of Power: International Law in an Age of Power Disequilibrium,” American Journal of International Law 100, no. 1 (2006): 88-106. Robert J. Delahunty and John C. Yoo, “Peace Through Law? The Failure of a Noble Experiment,” Michigan Law Review 106 (2008): 923-939. Cf. also Corbett, supra, at 51 (those scornful of stumbling attempts to create world law “display a lack of perspective no less real than that of the hurried idealists whose visions they deprecate.”).
6. Richard H. Steinberg, “Judicial Lawmaking at the WTO: Discursive, Constitutional, and Political Constraints,” American Journal of International Law 98, no. 2 (2004): 247-275 and Bernhard Zangl, “Judicialization Matters! A Comparison of Dispute Settlement Under GATT and the WTO,” International Studies Quarterly 52 (2008): 825–854.
7. Louis B. Sohn, Kristen G. Juras, John E. Noyes & Erik Franckx, Law of the Sea in a Nutshell (Minnesota: West, 2010) and www.un.org/Depts/los.
9. Harold Berman, Law and Revolution: The Formation of the Western Legal Tradition (Cambridge: Harvard University Press, 1983) and James T. Ranney, Heritage of Our Freedoms: Milestones in Legal History 16 (1987): 19-20 (slideshow transcript and coursebook) (on file with author).
10. Theodore F. Plucknett, A Concise History of the Common Law (Boston: Little, Brown, 1956), 118-134 and Henry G. Richard- son & George O. Sayles, The English Parliament in the Middle Ages (Philadelphia: University of Pennsylvania Press, 1981).
11. Oona Hathaway, “Treaties’ End: the Past, Present, and Future of International Lawmaking in the United States,” Yale Law Journal 117, no.8 (2008): 1236-1372.
12. Joseph E. Stiglitz, “A Real Cure for the Global Economic Crackup,” The Nation, July 13, 2009; David Kennedy, “The Mystery of Global Governance,” in Jeffrey L. Dunoff & Joel P. Trachtman, Ruling the World? Constitutionalism, International Law, and Global Governance (Cambridge: Cambridge University Press, 2009); David Rothkopf, Power, Inc: The Epic Rivalry Between Big Business and Government—and the Reckoning That Lies Ahead (New York: Farrar, Straus and Giroux, 2012); Ronen Palan, Richard Murphy & Christian Chavagneux, Tax Havens: How Globalization Really Works (Ithaca: Cornell Uni- versity Press, 2010); James Gustave Speth & Peter M. Haas, Global Environmental Governance (Washington: Island Press, 2006); and Pierre de Senarclens & Ali Kazancigil, Regulating Globalization: Critical Approaches to Global Governance (New York: United Nations University Press, 2007).
13. For a good example of the problem-by-problem type of analysis required, see Jeffrey Dunoff, “Institutional Misfits: The GATT, the ICJ & Trade-Environment Disputes,” Michigan Journal of International Law 15, no. 1042 (1994): 2-83.
14. See Paul Gordon Lauren, The Evolution of International Human Rights: Visions Seen (Philadelphia : University of Pennsylva- nia Press, 2010); Anatoly I. Adamishin & Richard Schifter, Human Rights, Perestroika, and the End of the Cold War (Washing- ton, D.C.: United States Institute of Peace Press, 2009); William Burke-White, “Human Rights and National Security: The Strategic Correlation,” Harvard Human Rights Journal 17 (2004): 249-280; and Hilary Mantel, “The War Against Women,” New York Review of Books April 30, 2009.
15. Richard B. Bilder, “Judicial Procedures Relating to the Use of Force,” in Lori Fisler Damrosch & David J. Scheffer, Law and Force in the New International Order (Boulder: Westview Press, 1991) and Peace With Justice: Selected Addresses by Dwight David Eisenhower (New York, Columbia University Press, 1961) (Eisenhower favors compulsory jurisdiction for ICJ).
16. See www.nobelprize.org/nobel_prizes/peace/laureates/1906/roosevelt-lecture.html (Theodore Roosevelt’s 1910 Nobel Peace Prize lecture urges creation of world court with enforcement powers via “some form of international police power”); David Kennedy, “The Move to Institutions,” Cardozo Law Review 8, no.5 (1987): 841-979; (prior to WWI, many prominent American jurists, statesmen, and industrialists, such as William Howard Taft, favored various forms of “world peace through law”); and Allan McKnight & Keith Suter, The Forgotten Treaties: A Practical Plan for World Disarmament (Melbourne: Law Council of Australia, 1983). (1961: McCloy-Zorin Statement of Agreed Principles for Disarmament Negotiations, initiated by Eisenhower and Kennedy, called for “general and complete disarmament,” with “procedures for peaceful settlement of disputes” and “an international police force”). See also Lincoln P. Bloomfield, ed., International Military Forces: The Question of Peacekeeping in an Armed and Disarming World (Boston: Little, Brown, 1964); Elise Boulding & Randall Forsberg, Abolishing War: Dialogue With Peace Scholars (Cambridge: Boston Research Center for the 21st Century, 1998); and James T. Ranney, “Beyond Minimal Deterrence—An Approach to Nuclear Disarmament,” Journal of World Peace 4 (1987):18-20.
17. Tad Daley, Apocalypse Never: Forging the Path to a Nuclear Weapon-Free World (New Brunswick: Rutgers University Press, 2010); “Press Launch – Abolishing Nuclear Weapons,” The International Institute for Strategic Studies www.iiss.org/events- calendar/2008-events-archive/September-2008/press-launch-abolishing-nuclear-weapons; and Lawrence S. Wittner, Confronting the Bomb: A Short History of the World Nuclear Disarmament Movement (Stanford: Stanford University Press, 2009).
18. See Jonathan Schell, The Abolition (New York: Knopf, 1984); Harold Feiveson, Richard Ullman & Frank Von Hippel, “Reducing U.S. and Soviet Arsenals,” Bulletin of the Atomic Scientists 41, no.7 (1985): 144; Robert Johansen, Toward an Alternative Security System (New York: World Policy Institute, 1983); and Mark Sommer, Beyond the Bomb: Living Without Nuclear Weapons, at 52-55 (Massachusetts: Expro Press, 1985).
19. Cf. Nina M. Serafino, “The Global Peace Operations Initiative: Background and Issues for Congress” (Washington, D.C.: Congressional Information Service, Library of Congress, 2009) (even the Bush Administration favored multilateral peace- keeping and stabilization forces).
Note to reader: For most recent edition of "BLUEPRINT FOR LASTING PEACE" go to. | 2019-04-23T06:18:50Z | http://www.endwarforever.com/BluePrintforaLastingPeace.html |
ShangPin product kindergarten continues comply with the education rules and keep to the children’s physical and mental development rules with foreign advanced education concept, a modern education facilities, human culture, and ecological environment of the green nursery since the establishment on 2007. Five star management of model kindergarten and established by the kindergarten experts.Shang product kindergarten covers an area of 6000 square meters; it owns 6 chain kindergartens including ShangPin International kindergarten, ShangPin Heping kindergarten, ShangPin Experimental kindergarten, ShangPin Fenghe kindergarten .
Shangpin is a funfair of children’s growth. In here, Education integrated with nature, the tiny saplings thrive exuberantly; in here, the experienced teachers are full of energy and hope as the spring.
Birds are the happiest in the forest. We hope the children will be happy as the birds, close to nature and soar freely.
Children are the flowers; they will grow up as the towering trees with the appropriate care and encouragement.
©copyright©2019 尚品幼儿园 All rights reserved. | 2019-04-20T11:24:33Z | http://spyey.com/ |
Marty Martin is a highly sought after presenter, trainer, and facilitator at organizations in the U.S. and abroad. His topics range from Managing Physician Performance to Elements of Teamwork. Marty currently serves as Director and Associate Professor of the Health Sector Management MBA Program at DePaul University in Chicago. In this role, he successfully launched three innovative programs: (1) dual MBA/MS degree with Rush University; (2) healthcare concentration in the M.S. in Predictive Analytics; and (3) M.S. in Health Informatics. As a writer, Marty has authored more than 100 refereed articles in journals ranging from the Journal of Health Care Finance to the International Journal of Computer Science & Technology. His scholarly and consulting work has been featured in stories appearing in the Wall Street Journal, Washington Post, and USA Today. He has also written two books-The Inner World of Money: Taking Control of Your Financial Behavior, published by Praeger Press in 2012 and Taming Disruptive Behavior, published by The American College of Physician Executives (ACPE) in 2013. | 2019-04-20T22:17:11Z | https://las.depaul.edu/academics/public-health/faculty/Pages/marty-martin.aspx |
Enjoy live music on Somerville's Division Street all season long as the Summer Stage concert series begins Friday, May 25. Here's this year's lineup: 5/25 - Mail Order Bride 5/26 - Cindi Rand and Arne Wendt 6/2 - Anna Oh 6/9 - Bob Lanza 6/16 - SunDog 6/23 - Terrance Haupt 6/30 - John Busse 7/7 - Mail Order Bride 7/14 - The Big Fuss 7/21 - The Paul Nagy Band 7/28 - Fast Forward 80's 8/4 - Run Down 8/11 - Bob Lanza 8/18 - The Green Planet Band 8/25 - Steel Groove 9/1 - Mama's Stew 9/15 - TBD 9/8 - Walnut Street 9/22 - The Moggy Hill Band 9/29 - Rewind Date(s): Friday May 25 and Saturdays, Memorial Day to Labor Day Time(s): 6:00 pm-9:00pm Location(s): Division Street For more information, visit Downtown Somerville's website. Don't miss the 75th anniversary of Tour of Somerville also happening Memorial Day weekend.
For more information, visit Downtown Somerville’s website. Don’t miss the 75th anniversary of Tour of Somerville also happening Memorial Day weekend. | 2019-04-23T02:08:28Z | https://njnext.com/somervilles-summer-stage-on-division-street-kicks-off-season-may-25/ |
Image Title: Air Bubble Tubs Bubble Bath Tub Air Bubble Tub Smart Bubble Bath Tub Throughout Whirlpool Tubs Reviews Plan. Filename: air-bubble-tubs-bubble-bath-tub-air-bubble-tub-smart-bubble-bath-tub-throughout-whirlpool-tubs-reviews-plan.jpg. Image Dimension: 360 x 360 pixels. Images Format: jpg/jpeg. Publisher/Author: Cruz Watsica. Uploaded Date: Wednesday - February 27th. 2019 02:44:49 AM. Category: Architecture. Image Source: homestyler.com.
Tap The Thumbnail Bellow to See Related Gallery of "Air Bubble Tubs Bubble Bath Tub Air Bubble Tub Smart Bubble Bath Tub Throughout Whirlpool Tubs Reviews Plan" | 2019-04-21T16:31:31Z | http://neastudents.org/album-of-whirlpool-tubs-reviews-decorate/air-bubble-tubs-bubble-bath-tub-air-bubble-tub-smart-bubble-bath-tub-throughout-whirlpool-tubs-reviews-plan/ |
Background: Diabetes mellitus is one of the most frequently encountered diseases in clinical practice and since the diabetic patients are at an increased risk of infections specially those of the urinary tract it is imperative for a physician to be aware of the prevalence and antibiotic susceptibility patterns of urinary pathogens. Thus, in this study we assess the recent trends in antimicrobial susceptibility patterns of urinary pathogens in type II diabetes mellitus.
Methods: Ninety-three eligible type II diabetes mellitus cases without genitourinary symptoms or abnormalities along with 93 non-diabetic healthy controls were recruited. Mid-stream urine was collected after taking informed consent and each sample tested using the dipstick, microscopy and culture techniques. Isolates were identified using standard biochemical tests.
Results: Prevalence of asymptomatic bacteriuria (ASB) in our study was found to be 34.4% among cases of type II diabetes mellitus while it was 6.45% among non-diabetic healthy controls. E. coli was the most common urinary pathogen isolated. E. coli susceptibility towards amikacin was 85.71%, towards ceftriaxone and nitrofurantoin was 71.73% and for meropenem and doxycycline 66.67% susceptibility was observed. In the one case where pseudomonas was cultured, it was susceptible to meropenem, gentamycin, cefoperazone-sulbactum and cefuroxime. In an isolated case where Proteus species was grown, it showed susceptibility to meropenem, norfloxacin, levofloxacin and co-trimoxazole. Enterobacter species which was grown, showed susceptibility to meropenem, vancomycin, amikacin, nitrofurantoin, norfloxacin, levofloxacin and co-trimoxazole. Gram positive bacteria mainly showed susceptibility to ceftriaxone, teicoplanin, vancomycin and doxycycline.
Conclusions: The prevalence of bacteriuria is significantly higher in diabetics as compared to non-diabetics and with the recent trends suggestive of emerging resistance among urinary pathogens to some of the commonly used anti-microbials it is of utmost importance to carry out regular surveillance of bacterial profile and their anti-microbial susceptibilities to formulate updated guidelines for effectively treating urinary infections in diabetic patients.
Saleem M, Daniel B. Urinary Tract Infections. LAP Lambert Acad. Publ. 2011.
American Diabetes Association. “Diagnosis and classification of diabetes mellitus,” Diabetes Care. 2009;32(supplement 1):S62-S67.
Vlad I, Popa AR. Epidemiology of diabetes mellitus: a current review. Romanian J Diabetes Nutri Meta Dis. 2012;19(4):433-40.
Yismaw G, Asrat D, Woldeamanuel Y, Unakal CG. Urinary Tract Infection: Bacterial etiologies, drug resistance profile and associated risk factors in diabetic patients attending Gondar University Hospital, Gondar, Ethiopia. Euro J Exp Biol. 2012;2(4):889-98.
Melaku S, Kibret M, Abera B, Gebre Sellassie S. Antibiogram of nosocomial urinary tract infections in Felege Hiwot referral hospital, Ethiopia. African Health Sci. 2012;12(2):134-9.
Worku S, Derbie A, Sinishaw MA, Adem Y, Biadglegne F. Prevalence of Bacteriuria and Antimicrobial Susceptibility Patterns among Diabetic and Nondiabetic Patients Attending at Debre Tabor Hospital, Northwest Ethiopia. Inter J Microbiol. 2017;2017.
Anejo-Okopi JA, Okojokwu OJ, Crown Ramyil SM, Bakwet PB, Okechalu J, et al. Bacterial and antibiotic susceptibility pattern of urinary tract infection isolated from asymptomatic and symptomatic diabetic patients attending tertiary hospital in Jos, Nigeria. Trends Med. 2007: 17.
Kebamo S, Dabsu R, Deressa A, Gebire M. Urinary Tract Infection: Bacterial Etiologies, Drug Resistance Profile and Associated Risk Factors among Diabetic Patients Attending NRH. Ame J Curr Microbiol. 2017;5(1):19-32.
Al Mously N, Al Arfaj O, Al Fadhil L, Mukaddam S. Antimicrobial susceptibility patterns of ESBL Escherichia coli isolated from community and hospital-acquired urinary tract infections. J Health Spec. 2016;4:133-9.
Sewify M, Nair S, Warsame S, Murad M, Alhubail A, Behbehani K, et al. Prevalence of urinary tract infection and antimicrobial susceptibility among diabetic patients with controlled and uncontrolled glycemia in Kuwait. J diabetes Res. 2016;2016. | 2019-04-21T16:22:54Z | https://www.msjonline.org/index.php/ijrms/article/view/4594 |
6 Pcs Super Mario Kart Pull Back Car Figure Set.Each Wind Up Car is about 1 "- 1.5" long.Perfect gift item for any Super Mario fan.Made of high quality PVC.Perfect cake toppers for holiday party or wind-up car toy.
Give all the Super Mario fans in your family a special treat this Easter with this set of 18 Mario figurines stuffed inside one giant Easter Egg! Crack it open to reveal favorite characters like Princess Peach, Yoshi, and Luigi. These fun toys are also perfect as kids party favors, birthday cake toppers, classroom rewards, piñata stuffing, and more! Each purchase includes 1 high-quality 8-inch jumbo Easter egg pre-filled with 18 Super Mario figurines.
18 Pcs (1 Set ) Super Mario Bros Super Mary Princess, Turtle, Mushroom, Orangutan , Super Mary Action Figures, 1.2 "- 2"
The super Mario brothers have a total of 18. They are good ornament. bedroom, car, drawing room and so on. They are also the children's toys. NOTICE:We pays great attentions to the shopping experiences from the customers. If you have any problems with our items or services, please feel free to contact us first.We will do our best to solve any problems and provide you with the best customer services.
Super Mario brothers figures set they are good ornament. Bedroom, car, drawing room and so on size: about 1.2 "- 2.8", material: PVC recommended: 3 + years old children. | 2019-04-18T16:30:24Z | http://costumoid.com/mario-party-toys.html |
This project successfully demonstrates Architectus’ ability to coordinate and negotiate the interests of a range of stakeholders, particularly various government agencies and the community, as well as meeting expectations and demand for this type of development in Central Sydney.
Architectus was engaged by City West Housing to prepare an Environmental Impact Statement in support of a State Significant Development for Affordable Housing at North Eveleigh. Architectus was also appointed the project architect.
This State Significant Development Application was in support of an affordable housing development comprising 88 apartments over seven levels. The application was lodged concurrently with a modification to the Concept Plan approval to amend the maximum height of the building.
Architectus prepared the Development Application to the NSW Department of Planning and Environment following a consultation process with the City of Sydney, NSW Heritage Office, NSW Police, Roads and Maritime Services, Urban Growth NSW and Transport for NSW. The extensive consultation process, including a community drop-in session, was a response to the constrained nature of the site and the broader North Eveleigh Precinct, listed on the State Heritage Register.
The approved development outcome was supported for its sympathetic design to its heritage context, crime prevention measures and the social benefits of the development to the locality, in providing affordable housing close to public transport and in proximity to jobs and amenities.
The application was approved within six months of lodgement of the Environmental Impact Statement. | 2019-04-22T06:41:24Z | http://architectus.com.au/en/projects/north-eveleigh-affordable-housing-planning-services |
The highly anticipated third installment of the Sounds from the Den series returns via Friday Fox Recordings – hitting on Vinyl in early 2017.
The release kicks off with an understated and rather sensual outing from Christian B & Lavvy Levan; ‘Through The Night’ combines subtle classic vocal snips with sultry jazz piano chords and an addictive off-beat bassline.
Russia’s Promonova serves up his first ever track for Friday Fox; ‘Feel Alright This Morning’ expertly delivers a high-energy percussive journey, perfectly complimented by some sprightly and authentically gospel vocals.‘No Trouble’ has a fresh and dark lick courtesy of Riki Inocente. Bordering on a tech-style, Riki takes this well-known vocal track down a path less travelled with a deep bassline and eerie strings laid over straight and solid percussion.
And finally, the HUGE ‘Heat’ from Rapson gets a much-welcomed edit, stretching the track to a DJ friendly length, and features some added beef thanks to new percussion arrangements. Fire. | 2019-04-23T14:39:24Z | http://housefm.net/music/reviews/item/3493-christian-b-lavvy-levan-promonova-rapson-sounds-from-the-den-vol-3-friday-fox-recordings |
Launched by the design house of Nautica, Nautica Classic features a masculine blend of waters, florals and aromatic woods. This men's cologne is available in a 3.4-ounce eau de toilette spray.
Top Notes: Bergamot, Lemon Oil. Middle Notes: Sage. Base Notes: Sandalwood, Amber, Musk. | 2019-04-24T04:09:41Z | http://www.kallony.com.ph/nautica-classic-for-men.html |
Chelsea, Bill, and big brother Jack welcomed Cora Joy on April 30. They are all home and doing well. They have been blessed with visiting family taking good care of them these first couple weeks, but will be on their own shortly. It is our turn to help out in a big way. We can cook and bring meals! Sign up for one or more dates below and arrange to drop off meals with Chelsea. Your help is much appreciated. | 2019-04-25T08:49:30Z | https://www.mealtrain.com/trains/y33mnk |
Thanks to its enormous compaction force combined with a quick forward and return travel, the DPU 6555 offers an extremely high level of productivity. It is a very versatile machine for all construction sites where extreme demands are placed on the performance efficiency. In addition, it offers excellent characteristics in terms of service life and operating comfort. Optimal application areas are the compaction of frost coverings and bearing layers in street, path and parking lot construction as well as backfilling buildings. Thanks to a frequency of 69 Hz, the DPU 6555 is universally applicable and even reliably compacts heavy interlocking paving stones. The model version DPU 6555Hec is equipped with Compatec, the compaction control by Wacker Neuson. This is also available as a retrofit kit for all DPU 6555He models starting with the year 2011.
Power transmission From the drive motor via centrifugal clutch and V-belt directly to the exciter. | 2019-04-19T01:17:57Z | https://beaconequipment.com.au/product/industrial/compactors/wacker-neuson-dpu4045ye-electric-start-diesel-plate-vibrator-copy/ |
A superior goal difference made Sunbird Livingstonia win the Fam Beach Soccer Cup national honors tournament on a daylong event held at the Jadore Africans Beach Stadium in Mangochi on Saturday.
In a statement from the Football Association of Malawi (Fam), The Director of Competitions and Communications, Gomezgani Zakazaka said this will go down in records as one of the most competitive beach soccer tournaments ever happened.
The letter further indicates that the five-team contest played on round robin basis, saw four teams tie on six points as Sunbird Livingstonia, Sunbird Nkopola, Karonga, Vinthenga of Nkhotakota all won twice and lost the same number of games.
Only goal difference would separate men from boys and the Salima based side emerged top with a slight advantage after outscoring the defending champions, Nkopola by a goal. Livingstonia had a goal difference of four after scoring 17 goals and conceding 13.
Nkopola had a goal difference of three for scoring 13 goals and letting in 10 goals into their net, reads the statement in part.
Livingstonia coach, Eston Skwiza thanked his boys for sticking to their plan of utilizing most of the chances.
He said: After this round of matches, it was clear that this would be tough contest and goals were going to play a big role in determining the winner.
We told our boys to score as many goals as possible. We ended up scoring 13 in two games and those goals won us the title.
Beach Soccer Association President, Kondwani Gondwe thanked Fam for the continued sponsorship requesting the mother body to consider raising the funding package.
Today we witnessed one of the most exciting tournaments. It was tight and that shows that teams are hungry for success as such we need more competitions and higher packages to motivate them, Gondwe explained.
A Fam Executive Committee Member, Rashid Ntelera said the association will continue supporting the game which has shown potential of making it big at international level.
We have won two silver medals at three international tournaments in which we have participated so far. That is an indication that we have what it takes to compete with other countries. We can only get better if we play at local competitions and we will ensure introducing more tournaments, Ntelera said.
During the daylong event, it ended Sunbird Nkopola 6 Sunbird Livingstonia 3, Nyerere 3 Karonga 3, Sunbird Livingstonia 7 Vinthenga 4, Nyerere 2 Sunbird Nkopola 1, Sunbird Livingstonia 1 Karonga 2, Nyerere 1 Vinthenga 3, Sunbird Livingstonia 6 Nyerere 2, Sunbird Nkopola 1 Vinthenga 3 and Karonga 6 Vinthenga 2.
Sunbird Livingstonia emerged champions of the Fam Beach Soccer Cup while Sunbird Nkopola were second and Karonga finished third with a goal difference of two after scoring 13 goals and conceding 11 while Nyerere from Nkhatabay finished last with four points.
According to Fam, the five teams qualified for the daylong event after winning the Presidential Cup in their respective zones. The champions pocketed K1.5 million while the runners-up got K750, 000 and Karonga walked away K500, 000 richer. | 2019-04-18T20:44:22Z | https://malawiwire.com/sunbird-wins-fam-beach-soccer-cup/ |
This makes no sense, according to Birmingham city councillor, John Clancy. He has just published a book, The Secret Wealth Garden, in which he calls for three major reforms of the current system. Firstly, he calls for management fees to be capped at an initial 0.02% of the fund's value. This, he says, would still give fund managers a tidy £43m in fees annually. Secondly, he says funds should be de-risked through an amendment to the Local Government Investment Regulations to require a shift away from equities (particularly overseas equiuties) together with a minimum holding in regional and local investment bonds. This, he says, could provide up to £20bn a year for investment in infrastructure and house building.
Capping fees, well, meh. However, the other two proposals are entirely nonsense.
The point and purpose of pensions savings is to diversify away from the risks that are inherent in having your income coming from only one or two places. Therefore you absolutely do not want to invest your pensions savings in the same economy that you inhabit. For example, unless you're getting a very good matching scheme from your employer investing your pensions savings in the shares of said employer is very much a thing not to do. The same will be true of the local authority pensions savings in the economy of that local area. Imagine that the area enters some horrible near terminal decline? There are, after all, areas of every country that are simply losing population, closing down as an economy. You simply don't want to have the pensions of those in that area reliant upon investments in said area.
So the local investment portion of this idea goes against the very grain of what we're trying to achieve with a pension, a diversification of risk. And who, no seriously, who, would advocate investment in bonds for the long term? When the price of money, the coupons on bonds, have been below the inflation rate for half a decade already? It's nonsense.
Older PostTax Freedom Day has finally come! | 2019-04-23T12:13:28Z | https://www.adamsmith.org/blog/uncategorized/this-is-a-terrible-idea-for-local-authority-pensions |
Working with a barn builder can feel overwhelming, especially if you’re new to the process. Quarry View Construction’s professional team helps eliminate that frustration and builds quality, long-lasting structures by using technology throughout the barn design process.
To share a behind-the-scenes look at how we design horse barns, equestrian facilities, garages, and other structures, we spoke with our in-house designer, Paul Campbell.
Paul started his career as a driver for Amish work crews. Later, he worked as a construction laborer before moving into drafting. Paul now works closely with clients and QVC project managers using 3D modeling program SketchUp, which allows him to quickly and efficiently design high-quality structures.
We handle your design, start to finish.
At Quarry View Construction, the entire design process is handled in-house. Paul says, “Our process gives you a much more accurate depiction of the project. The 3D modeling is much more artistic and easier to interpret when you’re not necessarily used to looking at the lines and symbols on a traditional architectural drawing.” The full-color renderings create a very realistic set of plans that take the confusion out of the building process.
Some jurisdictions, like a borough or township, require an architect’s seal as part of the building process. If you’re building a garage or other structure in an area that requires that designation, we’ll work with licensed professionals who can review and approve the architectural design.
We collaborate closely with you to build the barn you want.
The QVC team starts the barn design process by talking about your needs, wants, and budget. It’s a conversation that gives us the foundation to create an initial model.
“The first model is intentionally designed to be very simple, because it gives us the ability to discuss details and iron out what you’re looking for in your barn. For example, we can easily move door or window placement as we work through each version of the design,” Paul says. The structure’s design continues to evolve until it reaches the final rendering, which provides a realistic, full-color depiction of how the barn will actually look on the property.
We use computer-aided design to help crews build a better-quality barn.
Using 3D modeling software does more than help our clients visualize and plan a dream barn; it helps our work crews build a better structure, too. They use the construction drawings we produce to work more efficiently and eliminate guesswork from the barn building process. As a result, they produce a higher quality product that meets expectations—both ours and yours.
We build barns that blend modern design technology with Old-World quality.
Modern technology is just one facet of the process we use to build long-lasting structures, like barns and garages. Discover more about our unique process in Amish Horse Barns: Why Old-World Quality Matters.
To get the barn design process started on your dream structure, contact the QVBG team. | 2019-04-21T14:22:18Z | https://quarryviewbuildinggroup.com/barn-design-process-3d-modeling-meets-old-world-quality/ |
Bedtime at our house has a new development - MG is suddenly "very scared of the dark". Yup, it's true and I can't blame her. So one emergency run to Walgreens for a nightlight (fiber optic with butterflies & flowers mind you), the hall light on and lots of sweet talking, later and she's still not convinced. Nope, she wants to sleep clinging to daddy's mega huge contractor flashlight. You know, the kind that you could knock out an intruder with if you were feeling inclined!
Sorry folks, there'll be no Crafty Kids this weekend ... I ran out of time because I was lucky enough to spend some time with old friends. Thanks Bettina for coming to town and getting us all together. It was a pleasure!
So to make up for the lack of craftiness, I'm posting my Granny's jam tart recipe. It's a family classic that she served to her tea party ladies and I remember my mom always doing the same. It's yummy, easy, pretty and sure to please.
- Cool and dust with powdered sugar, enjoy!
In honor of my showcase spot on etsy today, I want to give you FREE things...seriously!
So here's the scoop. My new line of cereal box onesies is finally available... I've wanted to make them for years! Each one features a very cool vintage cereal box for your favorite yummy baby. They're great for unique baby shower gifts or just for fun. Besides the great illustrations and typography, you can't help but smile at the classic cereal flavors. There's everything from BooBerry, Alphabits and Cap'N Crunch to wholesome favorites like Wheaties. If you're like me, I'm sure you have a favorite from when you were little or at least one you always begged your mom for!
On to the freebies - it's super simple. The first 2 people to comment on this post will get a free cereal onesie of their choice from my etsy store (you choose size as well). So don't be shy ( I mean it) and best of luck to you!
I have a confession...I love candy. Yes, it's true and I'm not ashamed! All I can say is a little bit of something sweet makes me happy. It could be worse!
So the packaging designer in me is always on the lookout for new or redesigned products and when I see one of the sweet sort I have to give it a go. I spied the new Topps Wazoo bar today when I was out buying a non-leaky iron (thrilling purchase, I know) and snagged a couple bars. It's totally unlike anything else on the market, but not the yummiest of treats for me - kind of like a squishier Play-Doh colored Starburst that's covered in berry flavored yogurt with Nerd-like sprinkles. The packaging is really bright, fun and colorful though.
It's official - I'm in business!
What's bright and happy and looking for new friends? My hot off the press Lavender Kitty business cards! I finally took a moment to design some cards for myself (which is way harder than designing for other people) and am now feeling official. I even made them 2 sided with different backs...hey, it's been a long time coming!
If you love sewing and you're like me, you've probably got a stash of fabric scraps that you can't stand to part with. Seriously, I bought a bag of scraps at a Denyse Schmidt workshop and have been adding to it for years. I think it's growing overnight, but I love them all!
1. Have fun diving through your scraps and find a few favorites.
2. Quilt them into 5 inch squares - there's no rules, so have fun!
4. Sew right sides together, leaving a gap for flipping right side out.
5. Flip and sew 1/4 inch from edge to finish.
6. Add a pretty ribbon and give to a favorite friend's baby for bath time.
Spring is here - finally!!!! So to celebrate, this week's craft welcomes back the birds. It's super simple and uses things you probably already have in your house. Bonus!
Have kids thread O's onto the pipe cleaner (snacking while threading is highly recommended). Once there's a bunch threaded on, bend the pipe cleaner into one of your favorite shapes and tie a piece of ribbon or yarn for hanging. Run outside, have your kids find a great branch and hang up your Chirpy O's creation. Take a few laps in the yard and keep an eye out for the happy snacking birds.
My dad is heading over to Ethiopia in a couple weeks, so I thought I'd feature his new font "Hanna". It was designed to generate additional income for an orphanage in Ethiopia.
Hanna Teshome runs an orphanage of roughly 140 children in Addis Ababa, Ethiopia. She is an amazing lady with a deep passion for orphan kids as well as innocent kids that find themselves in jail because their mothers have been imprisoned - they are treated as prisoners and are typically sexually abused - it is not uncommon for them to commit suicide when they are released from jail at age 18. Most of the orphans end up with Hanna because one or both of their parents have died from AIDS.
Hanna relies entirely on donations to keep her orphanage running and this font is a small but tangible way to help make a difference in the lives of the orphan kids. Hope it inspires you to think out of the box when it comes to ways of donating to your favorite charity.
MG and I had a blast at the park this morning with friends, but this afternoon is rainy, rainy, rainy. Hopefully it'll make my garden grow like crazy! So, what to do when it's pouring and you're waiting for Aunt Meg and Baby Ivy to come over? Why drool over some fun stuff online of course!
The P'kolino Klick Desk. Talk about great design - it's colorful, modern and doesn't need a lot of space. Plus I LOVE anything that just needs to be closed up to look clean. Wish my whole house was like that!
Hope you're having a cozy happy day in your neck of the woods!
Introducing Crafty Kids - Crazy Crayons!
I'm so excited to unveil Crafty Kids - each weekend will feature a free and easy craft project for you to make with your kids. Hopefully it will encourage a bit of family time and a love of art...or maybe it'll help with boredom on a long day...we've all had some of those!
-Pop out crayons and go coloring crazy!
Wow, I can't believe we're back to Friday again. Maybe it's my rapidly advancing pregnancy or the upcoming arrival of Spring (we all can hope and dream), but the pace has definitely picked up!
I decided to feature a classically based font this week. Terzo is our newest addition and I'm proud to say it's one of the featured Hot New Fonts on Myfonts.com. The only reason I can say that is I had nothing to do with it's design - wish I did! Terzo uses three lines in the main stem of the capitals resulting in an interesting display of script capitals. Flourishes are uniquely positioned and are deliberately minimalist in order to feature the three part stem capitals.
The overall result is a well balanced and refreshing script that will serve many purposes! Think announcements, wedding invitations, restaurant signage, book covers, etc. If you're looking for a unique script this may be the font for you!
Lately I've had kid's clothing and the economy on my mind a ton. Mostly because it's so expensive to keep little ones in clothes that fit, besides being cute! So I've been designing sewing patterns for children that require small amounts of great fabric (fat quarters) but deliver big oomph.
Here's my latest, the Clementine Dress. It's comfy and sweet, plus the dress is cut in a way that should easily last a whole season - nice on the wallet! The pattern will be available in my etsy shop by the weekend (I'm going to burn the midnight oil getting it done, promise!). Also, many of you have asked if I'm selling my dresses, pinafores, etc. Truthfully, I never expected people to ask, but am excited to say that I'll have some in my shop soon. If you're interested, please take a look over the next few weeks.
Nothing is more beautiful to me than children's artwork. They have a great sense of style and no fear of what's right and wrong. Why not draw an egg with eyes or a ladybug with stripes? It's too bad that most of us grown-ups learn to only create perfect works that serve a purpose or meet a goal. Yes, I'm preaching to myself as well!!
So here's a few faces that MG drew this morning (Auntie Lindsay & Beebop - my dad). Hope they make you laugh and encourage you to try a few new things regardless of a "perfect" result. Hey, you never know!
I'm a total sucker for fabric, I have it stashed everywhere! So needless to say the Alexander Henry Bolero fabric called my name this weekend in the store. Actually it screamed and made me buy a 1/2 yard - see, technically it's not my fault!
Anyway, I wanted to make a no-brain needed sewing project with it for MG. Thank you Two Little Banshees for a great free toddler skirt pattern that's super easy. I used it for inspiration (switched up a few measurements & added rick rack) and was done in under an hour. Just enough time for a two year old to play happily before getting bored. Phew!
Thanks to Aleta Meadowlark at Omnomicon for the most fun, colorful cake ever!!!
I saw this rainbow cake recipe a little while ago and couldn't resist. Let's be honest, I'm not a kitchen guru so I fully appreciate and love folks that are able to make delicious goodies. This cake is about my speed...it's easy and mostly involves mixing colors (aka. arts and crafts class). MG and I had a blast squeezing gel food color and mixing insane batter colors. It was messy, delicious and the perfect creation for my friend Karly's birthday. Shh...she's only getting it tomorrow...I'll post another photo once it's sliced.
So if you're looking for a little unhealthy, but tasty fun or a great time with your kids, bake a rainbow cake. Trust me, it's sure to bring a smile to all.
PS - if you're nervous about the sugar free pudding and diet soda, no worries I skipped them both. I baked this cake with regular Sprite and it came out just fine.
Petronella Rullman was my dad's mom. When she was young she traveled by passenger liner to South Africa to be a nurse and for a bit of adventure. Sounds like a fun lady to me!
Anyway, during World War II, several members of my family in Holland and my grandmother in South Africa wrote daily journals to each other describing war time life (the family home in Holland was 4 doors down from the Frank home - as in The Diary of Anne Frank). When they could, they exchanged journals via the International Red Cross in Geneva.
While it's impossible to recreate someone’s handwriting, this font is an attempt to capture all the unique and stylish characters that were written with such sure strokes and amazing flare. The capital “P” and “R” in particular are unusually distinctive. I think you'll agree this script reflects an incredibly positive outlook.
New xStitch Pattern - Havens!
I'm really excited to introduce my newest cross stitch or xStitch pattern - Lavender Kitty's Havens.
Nothing in life is more cozy than your own personal haven. Whether it's a little cape, a Brooklyn brownstone, apartment building, farmhouse, duplex, cottage, townhouse, traditional colonial or castle, nothing beats home!
This cross stitch or xStitch pattern includes them all and is a great way to personalize your home. As a bonus I've added the chart for house numbers, should you choose to use them.
Each "haven" fits perfectly in a 3 inch wooden embroidery hoop and you can use whatever color floss suits your fancy.
Now I know...I know... cross stitching is old fashioned and not so cool. Well, if you've never tried it, you should. It's as easy as counting and very satisfying. Plus with a pattern as quick as this, it makes great little gifts for housewarmings, hostess goodies and making friends feel special. Who can say no that?!
So give it a go and maybe you'll discover something new to keep your hands busy while you're watching tv. Or, if you're like me, while you're waiting for your little one to finish a nap in the car. Story of my life!
Cupcake floss - need I say anymore?! Finally someone brilliant invented hygiene products for the sweet tooth like me. Hallelujah!
So if you have a kid that won't floss or you need a little incentive yourself, this may be just for you. Or...if you're dieting in the hopes of bikinis and warm weather this could satisfy a major sugar craving... who am I kidding, there's no substitute for a yummy cupcake with pink frosting!
Happy Tuesday everyone! I'm finally getting around to posting some free tutorials / patterns for those of you who are crafty inclined or would like to be. Actually, I truly believe all people are crafty, they just need to find what suits their fancy and go for it.
- Using color 3, tie a piece of yarn around the middle of your knitted rectangle. Knot it on the back and ta-da - it's a bow.
- You're done, hope you love them!
Oo, another bonus happened today - I remembered a super sparkly, very pink tutu I made for MG last Summer. I think I hid it for her birthday or Christmas? Not quite sure anymore. Guess that's what happens when you're pregnant with a 2 year old! Anyway, MG played ballerina to her hearts content and is thoroughly convinced that they play soccer. Could be, you never know?! | 2019-04-21T06:53:30Z | http://lavenderkittykat.blogspot.com/2009/03/ |
The HastaPada Yoga Belt makes a great companion to Eggs! Its unique two loop design to fit either a hand (hasta) or foot (pada) is innovative and useful in a variety of poses. This belt can also be used to carry your yoga mat. | 2019-04-18T12:40:13Z | http://www.threeminuteegg.com/yoga-belts-straps/ |
SuperCoil Set; Coil On Plug Style; Yellow; 6 Pack. WARNING CA Proposition 65: No.
These Coils Feature Advanced Bobbin Technology. Specialized Silicone Magnetic Steel Cores w/Optimized Windings. Specialized High Temperature Epoxy Filled Housings. Resists Shock/Vibration/Chemicals/Overall Engine Bay Environment.
Molded Bodies Have High Dielectric Strength. Installation Usually Takes Less Than An Hour. OBD II Compatible; Will Not Trip An Engine Code. Supercoils produce up 15% more spark energy then OEM, better throttle response, maximize fuel mileage, less than an hour to install. For more than 40 years, ACCEL has been a leader in performance fuel and ignition systems, proving itself on the racetracks and drag strips of the world - and on the street. With an ever-expanding line of SuperCoils and all the spark plug wires, tune-up kits, and fuel injectors hot rodders have trusted and relied on for years, ACCEL is constantly developing innovative new products designed to push power, speed, and performance to match advancements in automotive technology. Now part of Holley Performance, ACCEL offers a comprehensive selection of performance products, including coils, digital fuel injection systems, fuel injectors, distributors, caps, rotors, ignition wires, spark plugs. V6 FLEX DOHC Naturally Aspirated^^. All retruns must be in original box unopened.
We reserve the right to refuse any return. The item "ACCEL 140648-6 SuperCoil Set" is in sale since Sunday, July 29, 2018.
This item is in the category "eBay Motors\Parts & Accessories\Car & Truck Parts\Ignition Systems\Coils, Modules & Pick-Ups". The seller is "danshouseofspeed" and is located in Multiple Warehouse. This item can be shipped to United States, Canada, United Kingdom, Denmark, Romania, Slovakia, Bulgaria, Czech republic, Finland, Hungary, Latvia, Lithuania, Malta, Estonia, Australia, Greece, Portugal, Cyprus, Slovenia, Japan, Sweden, South Korea, Indonesia, Taiwan, South africa, Thailand, Belgium, France, Hong Kong, Ireland, Netherlands, Poland, Spain, Italy, Germany, Austria, Israel, Mexico, New Zealand, Philippines, Singapore, Switzerland, Norway, Saudi arabia, Ukraine, United arab emirates, Qatar, Kuwait, Bahrain, Croatia, Malaysia, Brazil, Chile, Colombia, Costa rica, Dominican republic, Panama, Trinidad and tobago, Guatemala, El salvador, Honduras, Jamaica. | 2019-04-25T02:39:11Z | http://accelsupercoil.us/accel_140648_6_supercoil_set_5.htm |
9 out of 10 based on 932 ratings. 2,926 user reviews.
MITSUBISHI ELECTRIC WD-Y57 SERVICE MANUAL Pdf Download.
View a manual of the Mitsubishi WD-Y57 below. All manuals on ManualsCat can be viewed completely free of charge. By using the 'Select a language' button, you can choose the language of the manual you want to view.
Mitsubishi Electric WD-Y57 Service Manual. Download Service manual of Mitsubishi Electric WD-57732 TV for Free or View it Online on All-Guides. This version of Mitsubishi Electric WD-57732 Manual compatible with such list of devices, as: WD-57732, WD-65732, WD-73732, WD-Y57, WD-Y65.
WD-Y57 aa WD-Y65 WD-57732 WD-65732 WD-73732 OWNER’S GUIDE • For questions: - Call Consumer Relations at 800-332-2119. - E-mail us at MDEAservice@mdea. - Visit our website at www.mitsubishi-tv. • For information on Demo Mode and System Reset, please see the back cover. | 2019-04-20T23:02:44Z | https://app-wiringdiagram.herokuapp.com/post/mitsubishi-wd-y57-manual-pdf |
At Airport Transport Centre, we like to keep you up to date with everything to do with transfers, transport, travel and more. That�s why we�ve created our blog page. Read some of our latest posts below.
Using an airport transfer service such as the one provided by airport transfer centre is a great way to reduce stress prior to your journey. Ensuring you get to and from the airport on time can be a stressful experience, especially if you�re travelling with a group or your family. Not to mention landing at the airport before hiring a taxi in an unknown location. A lack of knowledge about everything from the route to the price could mean your holiday gets off to a bad start. That�s where we come in. We can provide you with a fully professional service that takes care of everything for you. We�ll meet you at the airport before transferring you and your fellow travellers to your destination with the minimum of fuss, all with an upfront pricing system you can trust and without any hidden charges.
Travelling to or from the airport yourself or with an inexperienced driver could result in unnecessary delays, particularly if you find yourself getting lost. With an airport transfer service such as the one we provide, however, we can provide you with highly experienced drivers who know their way around a wide range of cities, meaning you never have to worry about getting lost again. Instead, you can focus on the important task of enjoying your trip, safe in the knowledge that you�ll be taking the best possible route for your transfer.
Airport transfers should be as comfortable as possible, especially if you�re getting on or off a long haul liight. Many local taxi firms may offer experienced drivers, but they don�t offer luxurious and comfortable cars for you to complete your journey in. With a professional transfer service, however, you get to choose the type of car you wish to travel in prior to embarking on your journey. That means if you want total luxury, you can guarantee it. Even the economy options with a professional transfer service such as ours provide you with great, highly comfortable transfer solutions.
With a transfer service, you�re given a quote prior to your journey, and with Airport Transport Centre offering fixed prices, you can be sure that the price you receive on your quote will be the price you pay. With taxi services you may end up paying higher rates simply because you get stuck in traffic. | 2019-04-24T10:02:29Z | https://www.airporttransportcentre.com/blog |
For months we’ve witnessed Apple (Nasdaq: AAPL) defy industry norms by growing even as the rest of the PC market fell. No longer. Depending on whose data you trust, the Mac maker saw U.S. sales fall between 6% and 7% year over year during the third quarter.
Lenovo — the Chinese computer maker that took over IBM‘s (NYSE: IBM) PC business in 2005 — was the lone grower, improving sales by at least 6% over last year’s Q3.
Don’t take that to mean Apple did poorly. Quite the contrary: The Mac maker added about a point of market share over the past year and now ranks as the third-largest PC supplier to the U.S. market, according to data compiled by researchers Gartner and IDC. Lenovo ranks fourth in the US, and is vying for the top spot worldwide.
Not surprisingly, Dell (Nasdaq: DELL) and Hewlett-Packard (NYSE: HPQ) appear to have suffered the most from Apple and Lenovo’s rise. What’s interesting is that the situation may be even worse than the numbers suggest. Why? The iPad.
Sources: Gartner and IDC. *Units in thousands.
As ripe a disruptive opportunity as the PC market appears to be right now — right around the world — it’s the iPhone 5 that Apple investors care about most. Yet that may change soon. Earlier this week, The Wall Street Journal reported that Apple has ordered 10 million “mini” iPads in order to meet outsized demand. Could a move to introduce a lighter, smaller iPad help move consumers even further away from PCs and stop the stock’s recent decline? | 2019-04-26T15:50:56Z | https://www.fool.com.au/2012/10/12/meet-the-company-thats-outgrowing-apple/ |
The Google Home Max was released on May 9, 2018, in Canada, Geeks and Beats were invited to the launch party. We gave away a FREE Google Home Max recently on a recent episode. My review unit, however, was lost in transit for the better part of a month, which is why this review has taken far too long.
The Google Home Max is the latest in Google’s existing line of smart home speakers which first launched on December 11, 2017, in the US. What sets the Google Home Max apart from Google’s previous smart home speakers besides its larger size is sound. The Max is a premium speaker – set at $499 CAD – focusing on music playback, both in sound quality and volume. The unit was designed for music and it delivers, from the deep bass response to the rich textured output.
Set up is simple and requires the download of the Google Home app which is used to set up all of Google’s ecosystem of smart home devices. After the installation of the ubiquitous system update, the 11.7-pound speaker was ready to learn your voice and respond to voice commands. The Max uses your unique voice to customize its responses, so for example if you say “Ok, Google, call mom” it knows to call your mom and not your partner’s. Up to six distinct voices can be added in this way.
Beyond the regular Google Assistant tricks, like telling you the weather and setting cooking alarms, the Max really shines as a music playback speaker. With its six built-in microphones, the Max uses machine learning to match the acoustics of the room and location it is set in. For example, when placed against a wall it will adjust its bass response. When paired with another Max unit the devices will work together to provide left and right output. Each auto-tuned for their location inside your space.
While I have been a smartphone user since 2001, with a then-beta Handspring Palm OS Smartphone, I have not fully embraced the latest voice assistant features, like Siri and Google Assistant. This in itself is odd given my affection for Classic Star Trek and its voice-controlled computer system. Outside of the car, I have never found it that convenient to talk to my phone. I am usually out in public or work where talking out loud still seems out of place. So the idea of an always listening “speaker” was difficult to get used to at first. However, the Max is slowly starting to find its way into our normal routine.
In spite of being slow to adapt to voice assistants, I had previously fully adapted to Google’s Chromecast Audio streamers. Once I grasped what these inexpensive devices could do, I quickly added them to all the devices around my home that had a line input. This seamless network interconnected with my home WiFi and created a whole home music system. The Google Home Max effortlessly connects with this network of music playback devices and becomes the voice-controlled centre of the system.
The Google Home Max, when paired with other compatible home automation systems can also become the easy-to-use control hub for these devices. Controlling home lighting, security systems, and thermostats. I only had one such device in my home – the Honeywell Lyric thermostat. The Max found and configured the WiFi thermostat automatically and can now be controlled with simple voice commands using the Google Home Max.
This unexpected home automation control got me thinking about what other home automation devices I could add? I will leave that for a future article.
Given the primary function is music playback, one limitation that quickly becomes obvious is you really need to subscribe to some form of music subscription service to really take full advantage of the music capabilities. The Home Max supports a lot of services including Spotify or Google’s own Play Music. Without this, you will only have limited control of what music can be played back unless you already have a large cache of your own ready-to-stream music.
For the purpose of this review, I signed up for Google Play Music service, this was in addition to my own music collection that I uploaded to the Google Play Music storage years ago. While interacting with the Max it was difficult to tell just where the music it was playing was coming from, my own library or Google’s. You can set up the default service that it queries for playback in the settings. However, since both of my sources were from Google it was impossible to tell if what it was playing titles from my own library or Google’s library. I found this frustrating at times, since every time you asked the assistant to play a song, it would continue playback of other songs based on your initial request.
I also found the voice control is still not completely natural, I often struggled to remember exactly the phrasing the device was expecting. This is one area that Google continues to improve. For example, in the month since the device launched in Canada, the Google assistant will now accept up to 3 commands spoken to it at once making for a more natural conversational interaction. Your own experience, of course, may vary.
While I am still hesitant about having a private companies device complete with AI software always listening in my home – one that now also knows my unique voice. Once you get past that the Google Home Max is a solid sounding premium smart speaker that delivers on its promise. | 2019-04-19T16:26:17Z | http://www.geeksandbeats.com/2018/06/introducing-the-google-home-max/ |
You will find many studios, flats, houses and villas for your holiday in Oranjestad. Contact the owners directly on the IHA site and enjoy the best rental prices, promotions and last minute deals that meet your budget. Visit the picture gallery on private lettings for a break with family or friends. All holiday listings on IHA are verified, plan your journey to Oranjestad with absolute confidence! | 2019-04-19T21:23:38Z | https://www.au.iha.com/holiday-lettings-oranjestad/iS/ |
Your Carnot home or commercial property can quickly become infested with mold if a source of water is present. Mold can spread throughout a property in as little as 48 hours. Since mold can produce allergens and irritants, you should call us to inspect your home if you suspect you have a mold problem. If mold is found, we have the training, equipment, and expertise to remediate your mold infestation.
We live and work in this community too; we might even be neighbors. As a locally owned and operated business, SERVPRO of West Hills is close by and ready to respond to your mold damage emergency. We are proud to be an active member of the Carnot community and want to pitch in and help make our community the best it can be.
To keep the mold spores from spreading further, we will use various mold containment procedures. Our professionals may use physical barriers and negative air pressure to isolate the contaminated area and to help prevent the mold spores from spreading through your Carnot, PA home or business. Also, we’ll turn off the property’s fans and heating and cooling systems to prevent the spread of mold.
Here at SERVPRO of West Hills we understand what it takes to properly remediate a mold situation in Carnot, PA. Encountering mold can be worrisome for any homeowner, but SERVPRO is here to put your mind at ease. We have the right tools and trained professionals to get the job done right. Give us a call at (412) 299-5520 and we will be on our way to help. | 2019-04-18T12:53:29Z | https://www.servprowesthills.com/carnot-pa-mold-removal-remediation |
Get your own state shaped coaster in bamboo! Show pride for your home or favorite state!
But the beauty of our country is no state is the same! Obviously, each coaster's height and width vary with each state's border. | 2019-04-20T08:35:31Z | https://mittenmadewoodcrafts.com/products/california-state-shaped-bamboo-coasters-set-of-four |
ADT has been helping to protect homes and families for more than 130 years. With over 130 years of experience, ADT is established at the forefront of home security in North Sioux City, SD, which is why more people trust ADT than they do smaller local security providers. Thanks to affordable and effective monitoring service, ADT is the best choice for North Sioux City residents to help keep their homes and families safe. With packages and services designed for almost any home, you won't find a better fit for your security needs than ADT.
Possible home invasion is only one of the many dangers facing your family in North Sioux City, SD. ADT has four interconnected monitoring centers that are staffed full time by professional dispatchers, ready to help respond to a break-in, a fire or even a medical emergency. Monitoring service is in place all day, every day so your home is never left without protection. Not only is ADT monitoring available to North Sioux City residents for about $1 a day, but professional monitoring may also make you eligible for a discount on your home insurance.
ADT monitored security systems offer professional protection with intuitive interfaces. Home security equipment can vary depending on the security needs of your home in North Sioux City, SD. From wireless sensors to infrared motion detectors, each piece of equipment plays an important safety role. Security equipment is easy to operate, protected by battery backup and installed by professionals so you know it's working. No matter which devices you ultimately choose, dependable home security equipment backed by professional 24/7 monitoring from ADT is essential to your home security.
Home security is an important investment for North Sioux City, SD residents to make. For the price of your morning coffee each day, alarm monitoring from ADT can help protect your home and end up saving you thousands of dollars in the long run. More important than stolen property or fire damage, ADT monitored home security systems provides you with the peace of mind that no matter where you are there is someone watching over your North Sioux City home. Call today to discover more ways ADT's monitoring can benefit you. | 2019-04-24T14:04:59Z | http://www.ushomesecurity.com/south-dakota/north-sioux-city |
There's a lot we could say about motherhood, and several things might come to your mind in the sub-category of things you "should know." One thing you should know is that it is unwise to keep the diaper rash cream tube next to your toothpaste tube. Not that I know anything about putting diaper rash cream on a toothbrush by accident, but I'm just saying you might want to find another place for it.
Besides that pearl of wisdom, there are ten things you should know about motherhood that will shape the way you see yourself, your kids, and the world around you. Give it a read over here at the Crossway blog.
Motherhood is evidence of God's mercy.
Motherhood is a gift even when your feelings disagree.
Motherhood is more than you can handle.
Motherhood is not a loss.
Motherhood gives glory to Jesus that echoes in eternity.
Motherhood flies in the face of fear.
Motherhood reminds us of our need for grace.
Motherhood is about a man-- Jesus.
- taken from "10 Things You Should Know About Motherhood" | 2019-04-22T01:04:27Z | http://www.gloriafurman.com/blog/tag/motherhood |
Guangzhou Yanse Cosmetics Co., Ltd.
safe to put back in your child's mouth. Storage Life 5 years Packing 338sheets/pack. Please store in room temperature.
TUNG YET TRADING SDN. BHD.
Alibaba.com offers 422 pink facial tissue products. About 64% of these are facial tissue, 1% are other beauty & personal care products.
A wide variety of pink facial tissue options are available to you, such as virgin wood pulp, recycled pulp, and non woven fabric. You can also choose from home, office & hotel, and travel. As well as from 2 ply, 1 ply, and 3 ply. And whether pink facial tissue is box tissue, pocket tissue, or roll tissue.
There are 426 pink facial tissue suppliers, mainly located in Asia. The top supplying countries are China (Mainland), United Arab Emirates, and Japan, which supply 96%, 1%, and 1% of pink facial tissue respectively.
Pink facial tissue products are most popular in North America, Domestic Market, and Northern Europe.
You can ensure product safety by selecting from certified suppliers, including 75 with ISO9001, 38 with Other, and 19 with GMP certification. | 2019-04-23T05:05:24Z | https://www.alibaba.com/showroom/pink-facial-tissue.html |
Protein The human body can't many snacks and in nondairy extremely serious drug-induced form of. The antivirals and the endothelin Safety and efficacy have not en kortademig bent. But ignoring the risk factors resting activity of dorsal-horn neurons. Some of the core science. I do HIIT (burpees and 10 pounds casion appealing, the follow through may be dominated in the snow) two times a lot of work just. online casino slots This is why I try that a detailed history is wander around and absorb the knowledge learnt during these years. She recommends doing measurements kelowna casino test to find out if single one of your organs, weeks) until you reach your. Below you can find resources for various health conditions, including in dissection, where the foundation is not understood until the. Foods do not get the chance to be digested properly smoking 3 to 6 a day (after 35 years I (2 30-pill trial size bottles). Studies show that people who temporary change in body fat distribution, with increased fat in in the College of Pharmacy.
Your body is actually designed M, McMurray J, Kaufman J, button below. I remember at the beginning JT, Mitchell MI, Bedding A, Warmer MR et al. play casino games online As you can see body. Plus, advancements in weight-loss surgery occur in the body as daily diet is allocated to eliminating microglia can thwart weight more than that, your body. When someone gives you xasino the fastest on the team. By eliminating after-school kelowna casino summer should include only such components K Poulsen1,3, T R Licht2, burgers and hot dogs), greasy is completed on our site Kosovo, keloana a bit of them and lose the job the Nayirah testimony. Some features are kept while.
Free admission at Archey Fork. While most Americans, particularly those has issued an announcement that it is injected instead of male ratsDinsmore WW, Hodges M, and Bioanalysis Laboratory LibrariesTemple Health citrate Viagra in erectile dysfunction: be over 28) -- before toxin-producing E. In our century, Kazuo Ishiguro with a medical history or years in a wheelchair Lauren weekends which would cancel out. casinos online Telotristat Ethyl: Moderate Use caution discussing such an intimate and to request a preferred gate more when you are bored kelowna casino race resume or other are eating. AllThingzJEN 3,617,360 views 5:52 30 difficulties with erections for more. Please contact us for up-to-date. Trying to keep up with others in a community is and see the choices that occurring, a relevant fraction of in VLDL particle size.
Yet unlike the investors featured appetite, smoking can make exercise and even normal activity such that ketogenic diets specifically aim to achieve elevated blood levels blamed supersized portions of pizza, years for bundling into bonds of your body burning fat. Need even more definitions. Is it a cold or allergies. Check your email to get and sight of children. I still have a few live longer, less painful lives. play casino games online Once you know your body push yourself to the max, diet potassium and protein contents. Counsellor with special training in. Exercise also builds muscle which carbs like quinoa, sweet eklowna and for all.
Keep me logged in New diet and weight loss, keep. The data and information that to shed new light on indoleamine 2,3-dioxygenase IDO1 inhibitor with guy thought there was something at some point, either every related enzymes such as IDO2 European Economic Area ("EEA"). It is designed kelowna casino men dry your skin like traditional. And trying to put them rubbish so I decided to cancer in laboratory animals. slot online The gentle waves help apply that is considered satisfactory for onto the casio layers of trump, spent too much time are scales which look and work like a weighing scale, the Blue Collar and Rural skin with visible results. British journalist Ambrose Evans-Pritchard interviewed and kelowna casino cuts of grass-fed. Kellowna you have kidney problems, calories, limiting portion sizes, resorting lawful manner, will exercise its rights issues, as they can high level of customer satisfaction, of the world without the takes an entirely different approach to weight loss and health.
Is there a difference between. Several small molecules possess the choose a variety of student-selected improve your digestion by breaking not be considered as a. ReplyHi Barbara, I am not used "Doctor Who" when the line that if true, the podcast and they make a asked to change it back different PDE5 inhibitor or proceed and other supplies. keelowna online casino slots If you don't have some to focus on are the home, consider joining a gym so that you can use. Legumes like lentils, split peas, stare at the cross with. Could you try to have work at the White House. I should clarify that I you many questions to assess.
Erectile Dysfunction treatment pills are up to a maximum of egg or dal preparation. How kelowan a patient obtain. I usually use the instrument because there are no gyms. slot game InhalantsClick to toggle dropdown menu. The technology underlying, and the Healthy eating Symptom Checker Follow forums Cancer Kelowna casino Diabetes Digestive health All conditions Ovarian cancer: what every woman should know Antenatal depression Managing eczema Headaches Health tips Fitness Czsino health States and other copyright laws, to tell someone you have Caskno, and is protected by copyright and other intellectual property or proprietary rights tried Pilates for 8 weeks and this is how it Teeth 13 of the best get rid of those annoying little red bumps on your don't get broody.
Losing weight also means levels saying what she was thankful erectile dysfunction for up to. Also, it depends where you Foundation, iStock, Getty Images, Corbis, an extra boost of radiance. No to Contraception, but Military the Frankfurt school naturally. Replace them with water, and party's sort of realizing the. casino games slots Bite Size Vegan has kelowna casino Staffordshire diners appreciate the social in name seeker heart sa I get home and it. Fullerton MD, Galic S, Marcinko in the breasts, waist, hips. However, on-going erection problems are achieve excellence in leadership through nonprescription keloowna for effective weight. Still, it took the participants be used when prescribing phosphodiesterase weeks to lose up to. Neurologic neurologic impairment or dysfunction patient thoroughly as a unique Plan, as well when it by moving your mouse across them out, and a surprising Trump tomorrow, the first cadino made after seeking advice from plant-based (WFPB) diet.
If your credit card or debit card has already been charged for the purchase and your order is canceled, DexaFit subconscious belief that you are to your credit card or Press review of documents and blast the "horrible" and "disgusting. Please give some suggestionsYou can going to build muscles, as is any form of exercise. Lactase is an intestinal enzyme you're looking for View All is slow to develop in 907 0050 Email: help ukmeds. You may also notice that adipose tissue, is a crucial kelowna casino stopping the breakdown of. Other negative addictive behaviors associated Lockean vision that constituted the common ground of American political. casino games real money The provisions of Article 102-XV words "quick weight loss" turned Advocate The Department of Insurance Wareham K, Yates P, Gingell the medical literature for the that promised users could drop 3 inform the patient of. Some foods include ingredients that have been genetically modified (GM), my GI tract. I started out using a calorie journal and the only thing I ielowna say about it is that it does Law comes into effect shall little bit more about how the position of Secretary General as you are writing and Secretaries General of the House of Representatives and the House. | 2019-04-20T10:11:17Z | http://xu-ljli-rixetebe.org/kelowna-casino.html |
Emme is quite new to ballet, but you'd never know it! Emme is ambitious, disciplined, and super fun! She's ready to dance any time of the day or night: this adorably soft little elephant even sleeps in her tutu. All she needs now is an equally passionate little friend to lie with. | 2019-04-24T19:55:04Z | https://nanahuchy.com.au/store/product/386 |
Click here to log-into your Sulzbacher Medical Center patient portal.
Volunteer opportunities at the Center.
If you lost your home, your job or your health, what would you do?
There are thousands of people in Jacksonville who have no one to turn to, no one who is able to help them when a crisis occurs in their lives. They are the reason we are here. Every day, Sulzbacher is home to more than 360 homeless members of our community, many of whom are children. But we offer more than a night’s lodging and a hot meal. We are a place for reinventing lives and for restoring hope. We help people in need find the way home. | 2019-04-19T14:52:45Z | http://sulzbacherjax.org/ |
For years, late afternoon has been our time.
Me, home from work, and them, from school... a time for catching up on the day, sharing tea, sitting close, just spending time. But life is different now with Laura away at school, and Camden sifting the through workload that his junior year has brought. His homework spills over to the weekend and it all boggles my mind. Too often I shout across the house I miss you, because truth cannot be held.
Five hours away is a mix of reaching out and holding back, seeking the best balance and not always succeeding. It is a work in progress, a long distance love, uneasy wonder and ache.
I am seeking a new ordinary, not quite sure where to start.
More than two months into a new school year and I am still marking time, still exploring my options and seeking courage to let go of that one golden hour. The possibilities are endless though... and maybe, just maybe, a new ordinary could be something to celebrate.
Oh my friend. I understand this....its hard to grasp the change. But I know YOU are rolling with it. A new ordinary....love that thought.
There will be amazing things happening in that hour soon. I just know it. Is that chai latte? It sure looks like chai latte. Can I bring my Rejoice cup and sit with you? | 2019-04-25T18:21:31Z | http://www.dawnsbeyondgrace.com/2013/10/just-hour.html |
This year, one of the most widely respected review platforms FinancesOnline did a thorough analysis of Setapp, which resulted in two honors at once: Great User Experience of 2018 and Rising Star of 2018.
In their review, FinancesOnline praised the selection of apps in the Setapp collection, absence of advertising or in-app purchases, timely updates, and overall affordability. After some social media research, the reviewers found 32 positive Setapp mentions on social networks and zero negative ones, which allowed Setapp to get a 100% user satisfaction score.
As a result, the team of experts ranked Setapp as one of the best RAD software products with an overall score of 8.9.
We are grateful to FinancesOnline for the review and are pleasantly surprised with the received attention.
If you haven’t tried Setapp yet, sign up for a free 7-day trial, use over 100 apps available, and independently validate the why behind all the awards. | 2019-04-26T05:52:45Z | https://setapp.com/news/setapp-receives-ux-and-rising-star-awards-from-financesonline |
Gesellschaft für Europabildung e.V. (GEB) is a certified non-profit organisation that is functioning as an educational training centre. At present our main aim is education and vocational education. In our area, we are working as advisors for institutions such as schools, small and medium-sized companies and administrative institutions. We have a strong network of European partners and we are helping in the planning, realisation and evaluation of European projects.
Am 13. E-Learning Tag der FH Joanneum am 17.9.2014 werden Klaus Himpsl-Gutermann (PH Wien) und Andrea Ghoneim (Donau-Universität Krems) ab 15:50 im Rahmen eines Workshops nicht nur das EUROPORTFOLIO-Netzwerk und seine Produkte präsentieren. | 2019-04-23T06:11:08Z | http://www.eportfolio.eu/domain/vocational-training?page=5 |
Description: This manual is primarily concerned with support to those noncommitted forces within the corps and communications zone areas. It describes responsibilities, relationships, procedures, capabilities, constraints, and planning considerations in the conduct of general engineering tasks. The manual was designed to highlight doctrinal procedures and to give an overview of the general engineering functional area. | 2019-04-18T14:37:27Z | http://enlistment.us/field-manuals/fm-5-104-general-engineering.shtml |
The area of Real Estate is one of MF&AC’s main areas of practice, our experience and knowledge allowing us to deal with complex operations regardless of its scope and complexity.
MF&AC is a team of committed and experienced lawyers, who benefit from having a highly prestigious academic consultant - in order to seek the best solutions for its clients based on high levels of competence and rigour. Our team provides a close follow-up with each client - favoring lasting, personalized and professional relationships. | 2019-04-22T16:48:07Z | https://www.mf-ac.pt/en/practice-areas/real-estate/42/ |
Somehow these just seem wrong. First, the Prisoner of Azkaban trailer featured giant toads and no one can figure out why. They seem to be missing from the print version of the story we're all accustomed to. Second, I don't think it's appropriate for Aragorn to put Anduril in his arm pit. Isildur wouldn't be pleased. There must be a more dignified image of the future king out there somewhere.
Dan gave me a digital camera for Christmas and I've been trying to learn how to use it. My first attempts can be found in the "Digital camera" section of my photo album. I would have taken pictures of my entire apartment, but at the moment I've turned it upside down packing for my trip. Speaking of my trip, I promised to post a diary entry before leaving tomorrow. That's next on my list of things to do tonight.
I intended to write a diary entry as soon as my final exam was over, but it seems I've been procrastinating. I am working on it, though. It'll be finished and posted before I leave for Tallahassee on Saturday. I promise.
I am taking a break from studying tonight to add some pictures to my photo album. New to the "UCLA" section are two pictures of Sevan and me using a Bunsen burner to warm our hands. I wrote about this on November 17, but I figured no one would believe me without proof. And I knew no one would believe that I saw Orlando Bloom on Wednesday so I posted the pictures Dan took of him in the "Return of the King premiere" section. I have much more to say on this subject, but I am putting it in a diary entry to be posted as soon as my final exam is over.
Looking at the posts I've drafted on both my computer and my Palm Pilot, there are about five from the past two days (and one really old one that I refuse to abandon) waiting to be finished. They are all based on ideas, topics, and events that I considered interesting enough to write about in the first place, so I am eventually going to complete them for my webpage. Also there are several new pictures to post. But night now I am consumed with the end of the UCLA fall quarter. Speaking of which, I am teaching my last discussion section of the aircraft combustion course tomorrow. Thank goodness.
It’s December. I just pulled my first all-nighter to finish a paper for my combustion class. And now there’s only one week until the final exam. The good news is that I’ll be done with the class as soon as it’s over. The bad news is that study time is running out. And since my advisor is also teaching the class I have to pass. I don’t even want to think what’ll happen if I don’t. | 2019-04-19T10:59:56Z | http://laurensweb.net/2003_12_01_archive.html |
In celebration of the two new series by Jo Dennis exhibited by Sid Motion Gallery at Photo London 2018, please read in full here an exploration of Jo’s practice and these new works. Written by Liz Jobey in the FT Magazine, 18th May 2018.
Read in full AnOther Magazine’s brilliant interview with Jennifer Louise Martin here. Jennifer’s work is currently on view at the gallery in the group show ‘Imagined Characters’ alongside works by Charis Entwisle, Pat O’Connor and Daniel Wheeler until 14th April 2018.
We were delighted to give ES Magazine’s Art Issue pointers on how to start a collection and collecting emerging artists.
Delighted to be interviewed about setting the gallery up in Kings Cross, and my upcoming exhibition programme in the 3rd issue of Kiosk Magazine. Out now.
Great to have our current exhibition ‘Turns on The Tarmac’ featured as one of AnOther Magazines’ Brilliant Things To Do in September. Words by Belle Hutton.
Read in full Arteviste’s review of our recent exhibit Colour, Order, System here. Words by Oliver Morris Jones.
Read in full One Art Citizen’s review of the current exhibition, Inner Landscapes: INNER LANDSCAPES: DAFNA TALMOR, BEN NASON, MINNIE WEISZ and MICK FINCH at Sid Motion Inner Landscapes runs until 2nd June.
The currently exhibiting artist, Morgan Wills, spoke in conversation with the writer and curator Sacha Craddock at the gallery on Wednesday 7th September. Their conversation explored Wills’ work in more depth, touching upon his references and influences.
We were delighted to welcome many people to the launch of the gallery on Wednesday 8th June. Sid Motion Gallery is now open, with the group exhibition ‘What’s it going to be?’, a painting show including the works of Damien Meade, Vincent Hawkins, Sophie Mackfall, Lawrence Corby and Kate Hawkins. | 2019-04-20T22:19:54Z | https://www.sidmotiongallery.co.uk/news/ |
Michelle CaffreyStudents at the Paulsboro Head Start smile as they check out the gift bags, donated by Mothers Matter, that they will give to their moms for Mother’s Day.
This Mother’s Day, thousands of moms across South Jersey will have a special treat waiting for them on Sunday, courtesy of the Lauren Rose Albert Foundation’s Mothers Matter program.
While the mothers — who may be dealing with their children’s hospitalization, difficult family issues or just trying to make ends meet — appreciate the gift bags chock full of beauty products and toiletries, they’re mostly taken aback by what the gifts mean —Thank you.
This year, the Mothers Matter volunteers—who rent out the old public works building in Washington Township to do their good works—will deliver nearly 2,000 gift bags to deserving mothers.
“Since we began in 2001, we started this program as a way to help moms who are facing challenges,” said President and Founder of the Lauren Rose Albert Foundation, Susan Rose. | 2019-04-25T06:35:56Z | https://www.laurenslegacy.org/our-journey/mothers-matter-charity-donates-thousands-of-gift-bags-to-moms-in-need-for-mothers-day/ |
First: Vote on the draft law of financial administration. (Finance Committee). (53 articles).
Second: The first reading of the bill of the Information and Communications Authority. (Committee on Services and Reconstruction, Committee on Culture, Information, Tourism and Antiquities). (57 articles).
Fourth: The first reading of the draft law on the accession of the Republic of Iraq to the agreement of the Asian Investment Bank for Infrastructure. (Committee on Foreign Relations). (2 articles).
Sixth: Report and discussion of the draft law of the first amendment to the Integrity Commission Law No. (30) of 2011. (Integrity Committee, Legal Committee, Committee of Civil Society Institutions and Parliamentary Development). (6 article).
"For the purpose of regulating the rules and procedures governing the financial and accounting management in the field of planning, preparation, implementation, control and auditing of the federal budget and directing all federal revenues to the public treasury to cover public expenditure and determine the link between the internal control units from the administrative and technical aspects and the mechanisms related to the implementationof budgets and the commitment of each implementing agency and determine the responsibility of the Ministry In addition to setting specific dates for the submission of audit balances and final accounts and adherence to the principles of the budget (transparency of the budget and the comprehensiveness of the budget and the budget unit) Annual budget and non-allocation) in the preparation and implementation of the federal budget and related matters in order to ensure macroeconomic stability and financial stability and strengthen the allocation of budget resources and improve the efficiency and effectiveness of spending and ensure the management of cash and optimize the quality of budget information submitted to the House of Representatives and the public. This law was enacted"
Today is the 10th of April. There is reason for them speaking of the 2019 Budget today.
The FML has specifics in the document that needed go be addressed on or before today. It has to due with reporting requirements and time lines set out in the legal document that has been enacted already. Thus, they apparently met that requirement.
My view is they may have met the requirement prior to paying the citizens starting Monday and on going through the 18th. Just before the ISX is to be linked with NSADAQ.
"A currency reform must be supported by financial sector legislation. Existing legislation—including the law establishing the central bank and regulation of banks and other financial institutions—should be reviewed to ensure consistency with international best practices.
A law and regulations on the specific currency reform are also necessary, and other legislation—for example, governing accounting and financial reporting—may require updating.
If Fred Flintstone would have been given a choice to drive a new 2019 Cadillac or keep busting his toes moving that stone-age buggy --- of course he was smart enough to go with the Caddy! And the citizens will also choose the Caddy!
The official further said that Iran had a lot of potentialities in the oil, gas, refining and petrochemicals sectors, adding: “Given the lack of development in the petrochemicals and gas industries in Iraq, there is a bright perspective for cooperation between the two countries.” He also said that Iran’s gas dues from Iraq stood at a billion dollars already.
The Integrity Commission announced the seizure of 14 officials and staff in the office of the province of Nineveh; on charges of embezzlement and waste of state funds, revealing the seizure of more than 15 billion dinars were under their pledge.
According to a statement of integrity, the investigations department of the agency reported that the investigation office in the province of Nineveh carried out five arrests under judicial arrest warrants resulted in the seizure of 14 officials and staff in the province on the basis of the provisions of Article 315 of the Iraqi Penal Code.
The department revealed that the bureau's staff seized 8 billion and 700 million dinars in cash, while seized 5 billion dinars dinars in the branch of one of the government banks, while seized the amount of one billion and 435 million dinars in the Department of Engineering of local administration in the Office of the province.
The Department pointed out that the arrested persons are the chairman and members of committees composed of; for the purpose of withdrawing the amounts of the rural development section of the projects for the rehabilitation of roads for villages and rural areas and distributed among the sub-committees, indicating that the total amounts seized by the owners of the bureau's offices amounted to 57 billion dinars, Is in the process of tracking the remaining funds. | 2019-04-24T18:41:04Z | http://www.dinardaily.net/t84101-beginning-of-the-end-ktfa-thoughts-news-4-11-19 |
Mad River is your ticket to exploring the wild and scenic Snake River. Whether you bring your family or come with friends, we can assure you, Snake River rafting will be the highlight of your trip to Jackson Hole. Come in early spring and experience an adrenaline rush in the peak flows of the river, come in midsummer and enjoy the refreshingly cool waters on a hot summer day or come in the fall and see the Snake River Canyon come alive in the reds, oranges and yellows of season.
Our professional and experienced river trip guides will navigate you through the twists and turns of the Snake River Canyon while pointing out the flora, fauna, geology and history that make this area unique. You can choose a scenic float and enjoy the upper section of the Snake River as it flows south along braided river channels, or you can choose a whitewater trip and shoot the rapids in the Snake River Canyon. Our friendly office and guide staff are happy to help make trip suggestions, or you can browse all our departures and book online at your convenience. We also have special packages when working with large groups. We look forward to seeing you here! | 2019-04-26T10:46:43Z | http://www.dealsjh.com/store/mad-river-boat-trips-jackson-hole-wyoming/ |
Randall King's automatic Swift Striker I is a great knife with a super price! Larger than the Swift Striker 2, this knife features a CPM-154 blade with a DLC black finish. The blade comes razor sharp, fires with a nice snap and locks securely into place. The knife body is anodized black T-6 aluminum. It’s got a good feel and we're quite impressed with the overall quality. There's a sliding safety on the front that works flawlessly and a pocket clip to make carry easy. | 2019-04-24T04:46:07Z | https://www.bladehq.com/item--Randall-King-Tactical--3666 |
Watch our 2018 Vitae 3MT® Competition finalists present live at the Vitae Researcher Development International Conference.
In collaboration with Taylor & Francis, we have created these bite-sized podcasts containing insights and handy advice about common issues and challenges often encountered by researchers, including the latest podcast on Open Research, launched for Open Access week.
Podcast from our Researcher masterclass on common challenges and techniques to turbocharge your academic writing and increase your research output. | 2019-04-25T20:31:51Z | https://www.vitae.ac.uk/vitae-publications/podcasts-videos-and-hangouts |
As this summer’s extreme drought and its aftermath prompt more New Mexicans to call for action to tackle global warming and the rise in extreme weather, Environment New Mexico released a new Environment New Mexico Research & Policy Center report today that shows that New Mexico’s current power generation from wind energy displaces as much global warming pollution as taking 232,000 cars off the road per year. Additionally, the Environment New Mexico report shows that wind power saves enough water to meet the needs of 11,600 New Mexicans.
With the right policies in place, plug-in vehicles can reduce oil dependence in New Mexico by more than 812,000 gallons per year.
As New Mexicans get ready for summer road trips, an Environment New Mexico Research & Policy Center report finds that cleaner, more fuel efficient cars would significantly slash oil consumption and global warming pollution across the state. The report, Summer on the Road: Going Farther on a Gallon of Gas, was released as the Obama administration is on the verge of finalizing fuel efficiency and global warming pollution standards for cars and light trucks that achieve a 54.5 mpg standard by 2025. | 2019-04-25T20:09:59Z | https://environmentnewmexicocenter.org/home?page=16 |
La Peche Electrique Ltee, Electric Contractors, listed under "Electric Contractors" category, is located at 7 Ch Jumon Wakefield QC, J0X 3G0, Canada and can be reached by 8194562429 phone number. La Peche Electrique Ltee has currently 0 reviews.
Browse all Electric Contractors in Wakefield QC. | 2019-04-23T06:43:19Z | https://ca.showmelocal.com/profile.aspx?bid=16081109 |
At Swift Brick Wall, we're available to meet your requirements regarding Brick Wall in Aydlett, NC. Our company has a staff of competent contractors and the most impressive technologies available to provide just what you need. We work with first-rate supplies and money conserving practices to make sure that you'll get the very best support at the greatest value. Contact us by dialing 844-233-1733 to start out.
At Swift Brick Wall, we realize that you want to stay within your budget and spend less money when it's possible to. You'll still want top quality results with Brick Wall in Aydlett, NC, and you're able to rely on our business to conserve your funds while still providing the highest quality results. We be certain that our cash saving goals will never translate to a decreased standard of craftsmanship. We utilize the finest materials and techniques to be certain that any task will stand up to the test of time, and we help you save money in ways which do not alter the excellent quality of your mission. We're able to achieve this by delivering the top deals available and avoiding expensive errors. Contact Swift Brick Wall when you'd like the finest support at a minimal cost. You're able to communicate with our staff by dialing 844-233-1733 to start.
Brick Wall are available in Aydlett, NC.
When it comes to Brick Wall in Aydlett, NC, you've got to be informed to come up with the most effective judgments. We won't inspire you to put together poor judgments, since we know just what we're working at, and we make sure you know very well what to be expecting from the task. That is why we try to make every attempt to ensure that you understand the strategy and aren't confronted with any unexpected surprises. You can begin by discussing your job with our client service reps when you call 844-233-1733. We're going to address all your questions and concerns and set up your first meeting. Our team will show up at the scheduled time with the required materials, and will work closely with you all through the job.
If you're considering a process regarding Brick Wall in Aydlett, NC, there's lots of great reasons to prefer Swift Brick Wall. Our equipment are of the highest quality, our money saving solutions are helpful and efficient, and our customer service ratings are unparalleled. We are aware of your expectations and objectives, and we're available to help you with our experience. If you need Brick Wall in Aydlett, choose Swift Brick Wall by dialing 844-233-1733, and we are going to be more than glad to help you. | 2019-04-25T17:41:46Z | https://www.swiftbrickwall.com/nc/brick-wall-in-aydlett/ |
Board index General General Discussions Need Reputation Points?
Harshit wrote: My IMP base has some reps as our squad is maxed out, if anyone wants their squad to get some rep, I will be happy to donate to them.
Harshit - See the Topic Post found here as well as look at the posts following for any Empire Squads requesting Reputation Donations.
Thanks for the list, DS !!
If you are on LINE app there is a new chat group for Imperial Reputation sharing. If you have a maxed lvl50 squad and wish to dontate to other squads, or if you have a lower level squad needing reputation points and want to be added to the list, then PM me on LINE (user ID: sgu97cab, display name Bacon [NSE] ) and I can invite you.
If your squad no longer needs rep please remove it from the list.
Yeap we'll very appreciate. Have a nice day!
sgu97cab wrote: Hi All Imperials.
Well I tried it, but it's way too messy and complicated, copy this paste that,, too many squads, I only wanted to dump a few reps now and again, will stick to the forum or word of mouth from now,, good luck though it's a good idea in principle. A positive thing. Just not for me.
A few months old imperial list I consolidated with ranks. It's been a while so these ranks are probably 2-3 higher now.
Our squad would be happy to receive your Rep! SithNAVY. searchable by typing Sith. The NAVY part is in blue and can be overlooked easily! Thank you!
Spawn Rising is looking to top off its reps. Level 47 or 48 atm. We need players too!
Spawn Rising is our feeder squad. We need active commanders. Join now!
Leia's~Coke~Nail is a new Level 29 Rebel squad that would gladly accept any donations. Squad is open, so jump in and dump anytime. | 2019-04-23T06:33:29Z | http://swcommander.com/viewtopic.php?f=31&t=21045&start=240 |
With extracts of Coconut and Almond, Boots Ingredients Intensive Hair Mask is specially formulated to condition the hair, helping to leave it feeling soft & smooth.
If you have any questions about this product by Boots Ingredients, contact us by completing and submitting the form below. If you are looking for a specif part number, please include it with your message.
Obliphica Professional Seaberry Medium to Coarse Mask, 8.5 oz.
The Real Golden Mask - El verdadero Baño de Oro - Brazilian Treatment Mirror Effect.
Olive Fruit Oil Deeply Repairative Hair Pak 250 ml. | 2019-04-19T09:01:21Z | https://www.beautysols.com/bsnp/boots-ingredients-intensive-treatment-mask-coconut-almond-400-ml-pack-of-4 |
Buy Jeff Dunham The Joint At Hard Rock Hotel & Casino - Las Vegas tickets. See Jeff Dunham at The Joint At Hard Rock Hotel & Casino - Las Vegas in Las Vegas.
Need somewhere to buy Jeff Dunham tickets for a show at The Joint At Hard Rock Hotel & Casino - Las Vegas? TonsOfTickets will fulfill all your needs for plenty of Jeff Dunham The Joint At Hard Rock Hotel & Casino - Las Vegas tickets on hand. We will make sure to get you the tickets for the The Joint At Hard Rock Hotel & Casino - Las Vegas concert in Las Vegas that you want. Don't hesitate to call us at 1-888-546-8539 if you have any questions about getting to your event.
TonsOfTickets provides all the best Jeff Dunham The Joint At Hard Rock Hotel & Casino - Las Vegas tickets at low prices. Our ticket inventory for Jeff Dunham in The Joint At Hard Rock Hotel & Casino - Las Vegas is updated by the minute and can be purchased by clicking the “Buy” button for any of the dates above. You will then be sent to our secure checkout page. Unless otherwise noted, your Jeff Dunham The Joint At Hard Rock Hotel & Casino - Las Vegas tickets will be sent via FedEx. In many cases, E-Tickets are available which allows you to download and print your Jeff Dunham tickets from your email. | 2019-04-19T01:02:26Z | http://www.tonsoftickets.com/concerts/jeff-dunham/the-joint-at-hard-rock-hotel-casino-las-vegas-las-vegas-nv/v2377/ |
How Many Ways Can You Justify Your Higher Price?
It's all about price. Low price. That's what every ad, every commercial, every pitchman focuses on. And they hit your customer between the eyes with it every day. So it's no wonder that your customers automatically react against your pricing as if it's the only thing to consider. Not respond, react. It's become a reflex.
If you told 10 people you were offering a new Ferrari for a hundred dollars, you'd get at least one knucklehead asking you to lower your price. It's not logical, it's simply a reaction.
But here's the question: What would you do when he asked? What would you say? What do you say? Because this price issue comes up every day in your sales business, does it not?
What about your offering will make your customer's life better? What pain will they continue to experience if they don't buy your product or service RIGHT NOW? Which extras, incentives, bonuses and promotions will they lose by saying no today? What goodies will they gain by saying yes?
If they buy, how much will they save - how much will they make - what will change - why will they be happier - how will they be protected - how will they be better off - who will notice them - who will respond to them - what will improve for them? Ten values is a good start. Now expand your list from 10 to at least 20. Create as exhaustive a list as you can. Employ fellow reps and other business associates. Ask your vendor who sold you the item in the first place. Ask your satisfied customers to give you their reasons they bought from you (you'll be blown away at some of their answers - great answers you probably were missing from your list!).
Now carry your list with you and look at it every day. Commit it to memory. Make your answers reflexive. That way, when somebody reacts with, "Your price is too high," you can react, too - with value, value, value. And when you do, get ready to hear, "Pop! Pop! Pop!" as their flimsy, automatic price objection bubbles burst, followed by a loud "Ka-CHING!" - the sound of your cash register ringing.
You'll get the money, your customer will get your valuable product or service, and you'll both be happy. This is called win-win. | 2019-04-23T22:03:54Z | http://salesadrenaline.com/sales-trainer/justify-your-higher-price.html |
crusher machine for thermal power plant. ... In a coal based thermal power plant, the initial process in the power generation is "Coal Handling'.
crusher properties in thermal power plant crusher properties in thermal power plant. heavy industry is specialized in the design, manufacture and supply of .
crusher properties in thermal power plant. heavy industry is specialized in the design, manufacture and supply of crushing equipment used in mining industry.
Roller Coal Crusher Price for Thermal Power Plant Introduction: Roller Coal Crusher ma. power are compelling the fuel is free, abundant and inexhaustible. | 2019-04-22T16:06:38Z | http://www.deepwoodz.in/digging-euipment/22188-crusher-properties-in-thermal-power-plant.html |
During my travels, so many people I met only stayed in Yangon (the former capital) for one night before moving on. What a shame. I spent six days there, and found it to be the perfect introduction to this beautiful land. I discovered the quirks, tasted the street food, learnt a few words, and adored the city. So much so that I spent six more days there before flying out, bought myself a longyi (traditional dress) and my cab fare is already tucked into my passport for my anticipated return. Sure, go to the Schwedagon Pagoda, and Bogyoke Market, but more importantly abandon your sunglasses, get lost, taste the street food, always look up, and don't forget to smile.
One of the views from my hotel room.
"Would you like to see buffalo swimming"? Would I what!! I could hear the majestic beasts huffing and puffing as they submerged themselves in the water. Months later I can still hear the sound and remember every moment of the hike. I went on two three day treks. One from Kalaw to Inle Lake, and one in Shan State, around Hsipaw. If you can only do one of those I would suggest the Kalaw to Inle Lake, as the scenery is a little more intense, although the latter is more authentic (and challenging). My advice is to make some friends before booking the hike (which is easy to do as so many people are walking around each afternoon trying to find the right trekking company). Ensure that your group is not larger than five, and that your guide speaks English as there is so much you are going to want to ask. I used A1 trekking, and they were amazing.
As i was eating my breakfast on the third day of the Kalaw to Inle Lake hike.
Morning fog on the third day from Kalaw to Inle Lake.
The Balloon Festival in Taunggyi in November is a once in a lifetime experience. Thousands upon thousands of people watch and revel as hot air balloons are released into the air.
Upon our arrival, we were approached for a photo, and thought nothing of it. But as we got further into the dance area hysteria ensued. At one stage I had thirty cameras in my face, which I welcomed after a Summer in Scandinavia amongst the world's most beautiful people. One girl stared at us, screamed and started crying with sheer happiness.
But then it was my turn to start nearly crying with joy when I saw that there was a human powered ferris wheel. It was on my list. Basically, the motor is eight Burmese boys resembling smoking spider monkeys in flip-flops who use the momentum to turn the wheel.
Many blogs and sites suggest flying within Myanmar, but I beg to differ. Sure, some of the train rides are downright uncomfortable, especially the overnight ones, but you have to pick your battles. My intention was to get the train from Thazi to Kalaw, but that went pear shaped as I was dropped off in Thazi at 4am, did not manage to find the train station five minutes walk away, and ended up on a shuttle instead with what seemed like a twelve year old kamikaze driver (i would advise against such transport). Luckily I got another opportunity to go from Hsipaw to Pyin Oo Lwin.
What better way is there to spend a day on a rickety train with locals watching the scenery, and feasting on 30 cent noodles from the vendors at the stops?
An added bonus was going over the Gokteik Viaduct which was completed in 1900. Scary as hell, especially when everyone moves to one side to get photos.
I repeat the slow boat. There are a few options, costing up to forty dollars, but we took the one that can take anywhere between fourteen hours and two days, depending on the water levels. It didn't bother me.
It departs incredibly early, and as you arrive there are families sleeping. Take a seat, and settle in for the day. No need to bring food, as at every stop there are merchants vying for your business. One woman saw me eyeing off her samosas, and was by my side in no time. Please remember to bargain, as the, "Shuddup and take my money" approach might see you paying triple what the person next to you paid. Did I say might?
Floating down the Irrawaddy taking in the scenery, seeing a glimpse of every day Myanmar, and the simplicity of these beautiful people going about their business gives you a sense of calm.
I kinda wish it had taken two days, and the next day at Bagan paled in comparison. | 2019-04-25T07:43:44Z | https://www.eurotash.com/blog/myanmar-burma-alternative-top-5 |
This alternative to block paving offers a traditional granite effect. Crazy paving is hard wearing and low maintenance. A block edging of your choice and colour compliments the outline. A decorative square or circle in the middle is often a popular choice. | 2019-04-20T18:28:54Z | http://www.fouroakslandscaping.co.uk/crazy-paving |
Notes: I didn’t make many images today, and the best one was this, taken with my phone… Oh well, it will have to do.
Notes: I’m always a sucker for a bit of grunge. I spotted this scarred paintwork on a bit of metal in the car park at Danbury Common, while Alistair and I were out having a walk this afternoon.
Notes: I finished work quite early today so was able to go for a walk around the village of Chiswell Green to mop up some geocaches which I either hadn’t looked for, or had had a go but failed last time. This was a rusty abstract I found near the second box I went in search of. | 2019-04-18T10:25:13Z | https://cazphoto.co.uk/2017/tag/paint/ |
Like all South African manufacturers, Bridgestone faces serious challenges. Among them are a flood of cheap imports, a shrinking domestic market, often fractious labour relations and low productivity levels. We do have a weak currency and good technical expertise, but it remains a tough climate for manufacturing.
And yet most commentators agree that a strong and growing manufacturing sector is the essential foundation for an economy that is expanding and creating new jobs. Both are absolute imperatives in this country, with its high unemployment rate and stagnant economy—and millions of people hungry to improve their lot.
Achieving manufacturing excellence is clearly critical if we are to stand a chance of exporting successfully, and of seeing off foreign competitors from ultra-low-cost countries. In our own case, we decided we really needed to take decisive action to change the way we did things in order to achieve these goals, and we decided that the Integrated Work System (IWS) offered us the principles and methodology we needed to do so.
We began piloting IWS some two years ago, and are now well into rollout, and the results have been encouraging.
IWS is an innovative approach to manufacturing originally developed by P&G and is presented in SA in association with EY. It was born of P&G’s ongoing drive to improve its manufacturing processes. It has two key principles: to strive to reach zero losses during the manufacturing process, and 100-percent employee ownership. It is all about engagement!
Our traditional leadership style was no longer effective or appropriate in today’s world, particularly as we have a new generation of better educated workers in our factories. We saw IWS as a way essentially to turn the traditional management structure on its head, and make the people who operate each piece of equipment the “boss”, in effect giving them autonomy. This means that the “owner” of each piece of equipment is empowered with the skills needed to undertake basic maintenance, take the lead in suggesting improvements and decision making at the coal face.
This requires a significant mind shift for everybody, not least the machine operators themselves. Finding yourself the point of accountability rather than a mere operator takes some getting used to.
One aim is to speed up decision-making. It’s similar to the way that reflex actions cut the brain out of the loop in order to make the split-second reaction that is required. By pushing decision-making—and thus accountability—down onto the shop floor, we will ultimately be able to remove two layers of management (supervisors and middle managers)—a huge cost saving combined with a significant gain in efficiency.
Of course, such a process does not happen overnight, and these middle managers will form the nucleus of the teams that will help the equipment owners make the transition over an average two-year period. It would be highly disadvantageous to lose their skills thereafter, so they will move into the centres of excellence that we have created to support the manufacturing operation, with a key focus on coaching on the floor (COTF).
Discernible performance improvements as people buy into the concept of taking ownership of their machine. Two operators have already been promoted into management positions.
Machines suffer fewer breakdowns because of ongoing maintenance, and some shifts have been able to be eliminated.
Uptick in operators completing their trade tests to facilitate the concept of autonomous maintenance.
Process improvements; for example, the merging of three control sheets into one has reduced the time spent on documentation.
Throughput on individual machines has improved by up to 44 percent.
Increased resilience as time saved (planned stops) by increased throughput used to reduce number of shifts, thus allowing for cross-training on other machines. This means the production capability is more flexible, and can respond to unexpected situations more easily.
These results are great but, for us, the biggest impact has been the way the machine operators have bought into the concept, and how they have blossomed. Some days we receive 11 suggestions for improvement—a sense of ownership and desire to contribute simply did not previously exist.
Some of the comments we have received include: “I feel IWS brings about meaning to my workplace… and brings about positive working culture”; “There is a change and things are now better”; “I can see improvement with regard to breakdowns and defect handling response time”; “IWS has shown BIG improvements to our standard of work. Now we work smart and see the results”.
It’s no exaggeration to say that the positive attitude shown by the machine operators has changed the whole dynamic in the facility and, as shown above, has also delivered concrete results.
Like all businesses, despite its reliance on machinery, manufacturing is essentially dependent on its people. IWS is showing us how true that is.
Franz Dill, “Integrated Work System”, available at http://eponymouspickle.blogspot.com/2018/02/integrated-work-system.html. | 2019-04-19T18:22:08Z | https://abrbuzz.co.za/aftermarket-buzz/8554-turning-manufacturing-on-its-head-and-reaping-the-benefits |
If you are thinking of selling your home, you'll need to know exactly what it is worth before putting it on the market. As Lansdowne area real estate professionals, we analyze home values and determine market prices every day. By comparing your home to recent sales and other, similar homes on the market we can quickly tell you what your home is worth. This analysis is known as "Comparative Market Analysis", or CMA. Just fill out the form below to give us the information we need and we'll be glad to perform a CMA for your home and provide you the results for free. | 2019-04-20T16:51:55Z | http://www.lansdowneproperties.net/FreeHomeValuation |
Advances in our understanding of the cellular and molecular mechanisms in rheumatic disease fostered the advent of the targeted therapeutics era. Intense research activity continues to increase the number of potential targets at an accelerated pace. In this review, examples of promising targets and agents that are at various stages of clinical development are described. Cytokine inhibition remains at the forefront with the success of tumor necrosis factor blockers, and biologics that block interleukin-6 (IL-6), IL-17, IL-12, and IL-23 and other cytokines are on the horizon. After the success of rituximab and abatacept, other cell-targeted approaches that inhibit or deplete lymphocytes have moved forward, such as blocking BAFF/BLyS (B-cell activation factor of the tumor necrosis factor family/B-lymphocyte stimulator) and APRIL (a proliferation-inducing ligand) or suppressing T-cell activation with costimulation molecule blockers. Small-molecule inhibitors might eventually challenge the dominance of biologics in the future. In addition to plasma membrane G protein-coupled chemokine receptors, small molecules can be designed to block intracellular enzymes that control signaling pathways. Inhibitors of tyrosine kinases expressed in lymphocytes, such as spleen tyrosine kinase and Janus kinase, are being tested in autoimmune diseases. Inactivation of the more broadly expressed mitogen-activated protein kinases could suppress inflammation driven by macrophages and mesenchymal cells. Targeting tyrosine kinases downstream of growth factor receptors might also reduce fibrosis in conditions like systemic sclerosis. The abundance of potential targets suggests that new and creative ways of evaluating safety and efficacy are needed.
The development of new therapies for rheumatic diseases was mainly empiric until recently. Most of the drugs that we used until the 1990s, including standards like methotrexate, were originally discovered for other purposes or were accidentally noted to be beneficial in autoimmunity. As the molecular mechanisms of disease have been unraveled, newer targeted therapies have been a stunning success. Understanding the importance of cytokine networks in rheumatoid arthritis (RA) led to the biologics era with agents that block tumor necrosis factor (TNF), interleukin-1 (IL-1), and IL-6. These biologics are also effective in other diseases, including seronegative spondyloarthropathies, autoinflammatory syndromes, and perhaps gout.
Despite notable achievements, currently available therapies are not effective in many patients with rheumatic diseases. The new biologics are ineffective in many individuals; in some situations, like systemic lupus erythematosus (SLE), no new effective therapies have been approved for decades. As our knowledge of disease pathogenesis expands, new pathways and mechanisms that can be exploited are emerging. In this review, we will discuss some promising targets that have arisen from recent research. Due to the breadth and depth of current research and space limitations, this is not an exhaustive review, but it does provide a taste of what is to come (Figure 1).
Intercellular molecules such as cytokines and their surface receptors can be targeted by biologics such as monoclonal antibodies, receptor-antibody fusion proteins, and, in some cases, small molecules. Intracellular enzymatic cascades convey the information from the cell surface to regulate the cell response, including transcriptional activity in the nucleus. Cell-permeable molecular compounds can block a specific kinase and transcription factors. Some surface receptors such as G-protein-coupled receptors represent another class of molecule that can be inhibited by small-molecule compounds. AP-1, activation protein-1; BLyS, B-lymphocyte stimulator; ICOS, inducible costimulator; IL, interleukin; IRF, interferon regulatory factor; LTβ-R, lymphotoxin beta receptor; NF-κB, nuclear factor-kappa-B.
The most dramatic therapeutic advances in the 'modern' era of rheumatology have focused on anti-cytokine therapy. As the cytokine network becomes increasingly complex, new and exciting possibilities arise. In this section, a few key cytokine targets are discussed.
Of the cytokines relevant to autoimmunity, IL-17 and its family have perhaps generated the most anticipation. In murine models of autoimmune disease, the Th17 subtype of T lymphocytes that produce IL-17 plays a pivotal role in pathogenesis . While the function of this factor in humans is less certain, it represents a unique T cell-derived factor that could participate in many rheumatic diseases. The IL-17 family comprises six members designated IL-17A through F, with perhaps the most important being IL-17A (which is the cytokine usually called 'IL-17'). IL-17A is found in the synovial fluids of some RA patients and can be detected in T cell-rich areas of RA synovial tissue [2, 3]. It, along with its closest homolog IL-17F, enhances the production of proinflammatory cytokines by fibroblast-like synoviocytes (FLS) and might amplify the effects of macrophage-derived cytokines such as TNF . Blockade of IL-17 with an antibody-based approach is very effective in collagen-induced arthritis (CIA) as well as many other models of inflammation .
There are several ways to block IL-17 family members. Conventional methods, such as monoclonal anti-IL-17A antibodies, are currently being developed for RA and psoriasis as well as other autoimmune indications. Subunits of the IL-17 receptor complexes (IL-17RA and IL-17RC) could be used to design soluble antagonists that can bind multiple members, such as IL-17A and IL-17F. The results of IL-17-directed approaches are eagerly anticipated for a variety of indications, including RA and psoriasis.
IL-12 and IL-23 are related cytokines that are secreted by macrophages and dendritic cells after cytokine or Toll-like receptor ligand stimulation. IL-12 is a key inducer of Th1 CD4+ T cells that produce interferon-gamma (IFN-γ), whereas IL-23 contributes to Th17 polarization. Thus, an IL-23-targeted therapy could potentially have a downstream effect on IL-17 production. When T cells are exposed to IL-23, the cells can be directed toward the Th17 phenotype. This is especially true in mice, in which exposure to IL-6 and transforming growth factor-beta (TGF-β) also contributes to Th17 cell production through the activation of STAT3 (signal transducer and activator of transcription 3) and induction of the transcription factor retinoic acid-related orphan receptor (RORγt). The system in humans is not as well defined and TGF-β might not contribute. Nevertheless, an IL-23-targeted therapy could potentially have a downstream effect by limiting the activation of Th17 cells and decreasing expression of IL-17 family genes. The interplay between IL-12 and IL-23 and autoimmunity can be complex; mice deficient in the IL-12 p35 subunit have increased severity of CIA . In contrast, mice lacking the p19 subunit of IL-23 are protected from CIA, as are p40 knockout mice, the subunit common to IL-12 and IL-23.
Even though IFN-γ is the signature cytokine of Th1 cells and is pathogenic in some models of autoimmunity, including proteoglycan-induced arthritis, the IL-12/IFN-γ axis can also be protective in CIA and experimental allergic encephalomyelitis (EAE) . IFN-γ also blocks Th17 development and can potentially enhance regulatory T (Treg) cell response [8, 9]. Strategies that interfere with IL-17 production like IL-12/IL-23 inhibitors or IFNγ can potentially enhance the suppressive activity of Tcells and limit autoimmunity. Treg cell numbers can also increase with other cytokine modulators, such as infliximab . The apparent reciprocal relationship of Treg cells and Th17 cells provides a potential way to alter immune responses and restore homeostasis through cytokine modulation.
IFN-γ is expressed at relatively low levels in the rheumatoid synovium and exerts anti-inflammatory effects in vitro and in some arthritis models . IFN-γ administration in RA shows minimal efficacy and caused disease exacerbation in multiple sclerosis. Patients could only tolerate a dose considerably lower than required to suppress arthritis in mouse models. Based on the results of clinical and preclinical studies, a selective IL-12-directed agent that interferes with Th1 cell differentiation without a major effect on Th17 cells might be less attractive.
Mouse and human T-cell systems clearly differ in many respects, which makes extrapolation from murine models difficult . As noted above, TGF-β is critical for Th17 differentiation in the mouse but might be less important in human cells. A large percentage of human IL-17-positive T cells also produce IFN-γ. While blocking Th17 cells might be sufficient in mice, efficacy could require suppressing both the Th1 and Th17 pathways in humans. This approach could involve interfering with IL-23, which is required by Th17 cells for effector function. IL-23 p19 levels were higher in RA than osteoarthritis synovial fluids in one study . However, another group detected low levels of heterodimeric bioactive IL-23 in only a fraction of RA synovium samples .
A monoclonal antibody against p40, the subunit common to IL-12 and IL-23, showed remarkable efficacy and a favorable safety profile in inflammatory bowel disease and psoriasis [15–17]. The results of a placebo-controlled phase II study in psoriatic arthritis are also available. Patients were treated every week for 4 weeks and received two other injections at weeks 12 and 16. ACR20 (American College of Rheumatology 20% improvement criteria) responses at 12 weeks were achieved in 42% of patients compared with 14% in the placebo group. ACR50 and 70 responses were also statistically significant (25% versus 7% and 10% versus 0%, respectively) .
The small molecule STA-5326 is being evaluated in a phase II trial in RA. In vitro, this compound blocks IL-12, IL-23, and IFN-γ production by cultured peripheral blood mononuclear cells, although the mechanism is not well established. In an open-label study, STA-5326 decreased clinical activity scores in Crohn disease patients. The clinical trials might help investigators to understand the role of the IL-12/IL-23 axis in different forms of human autoimmune disease.
Elevated levels of IL-15 are expressed in the synovium of RA patients and have been implicated as a mediator of TNF production by macrophages . This cytokine can also participate in joint inflammation by attracting neutrophils and T lymphocytes and by triggering the proliferation of memory CD8+ T cells. IL-15 can be bound to the plasma membrane or secreted, while a shorter isoform remains intracellular. The IL-15 receptor complex is trimeric and comprises the γ subunit (shared with IL-2, IL-4, IL-7, IL-9, and IL-21) and IL-2/15 β chains (shared with IL-2). The IL-15R α chain confers specificity toward IL-15. A human monoclonal antibody that binds IL-15 showed a modest ACR20 response in a phase II clinical trial at the highest dose, supporting a possible contribution of IL-15 in RA. These preliminary results are encouraging, although a second study failed to show significant benefit.
Elevated levels of BAFF/BLyS (B-cell activation factor of the TNF family/B-lymphocyte stimulator) and APRIL (a proliferation-inducing ligand) are found in the serum of patients with RA, SLE, and Sjögren syndrome. These two cytokines are members of the TNF superfamily and are expressed by various cell types, including monocytes, dendritic cells, osteoclasts, and synoviocytes . Both bind to receptors expressed on B cells, known as BCMA (B-cell maturation protein) and TACI (transmembrane activator and CAML interactor). BAFF receptor 3 (BR3) recognizes only BAFF/BLyS. These molecules perform similar functions in B-cell development and survival, Ig class switch, and costimulation.
Several different biologic strategies to block BAFF/BLyS and APRIL are being developed. Belimumab is a fully humanized anti-BAFF antibody that showed minimal efficacy in a phase II trial in RA . Belimumab was also evaluated in a phase II study in patients with active SLE. It failed to meet its primary endpoint, but subgroup analysis suggested that it might improve or stabilize disease activity in some patients . One potential problem with belimumab is that it does not block APRIL and hence might not have sufficient effect on B-cell maturation. TACI-Ig is designed to function as a decoy receptor with both anti-BLyS and anti-APRIL activity. Another agent, the BAFF receptor-Ig fusion protein, inhibits only BAFF. TACI-Ig is being evaluated in RA and SLE, and preliminary studies suggest that there is a significant decrease in serum immunoglobulins. Anti-BR3 antibodies with cell depletion activity and BR3-Fc are being developed for similar indications [21, 23]. The respective merits of strategies involving BLyS and APRIL are difficult to compare because their respective roles in humans are not yet fully understood.
The lymphotoxin (LT) system is also part of the TNF superfamily and includes lymphotoxin-related inducible ligand that competes for glycoprotein D binding to herpes virus entry mediator on T cells (LIGHT), LTα, and LTβ . All three ligands can bind the LTβ receptor (LTβR) and can participate in the development of the immune system and lymphoid organization. LTα also binds to the TNF receptors and its function is blocked by etanercept. In addition, LIGHT binds to another receptor, herpes virus entry mediator (HVEM). The LIGHT-HVEM interaction is proinflammatory, but HVEM also binds the B- and T-lymphocyte attenuator (BTLA), which suppresses immune responses.
Decoy receptors designed by linking the LTβR with the Ig Fc domain selectively inhibit the proinflammatory functions of the LT system. This strategy is effective in many animal models of autoimmunity, including CIA, EAE, and murine models of SLE and diabetes . LTβR signaling is required to develop and maintain tertiary lymphoid structures but is dispensable for many aspects of secondary lymphoid organ biology in adults.
In RA, lymphoid structures are seen in the synovium of up to 30% of patients. LTβR-Ig therapy might be especially effective in this subpopulation if these structures play a critical role in local antigen presentation and disease pathogenesis . In addition, synoviocytes can respond to LIGHT, LTα, and LTβ with the release of proinflammatory mediators. Early results from RA patients treated with LTβR-Ig have demonstrated some benefit, although a larger study reportedly did not demonstrate sufficient efficacy to warrant continued development for RA. However, other autoimmune diseases, such as SLE, are additional indications that could be evaluated with this molecule. Careful monitoring of host defense will also be needed given the important role of LTβ in germinal center organization.
Inflammatory and immune cell recruitment to target tissue is a hallmark of autoimmune diseases. This process is regulated by a class of proteins called chemokines as well as many small-molecule chemoattractants . More than 40 chemokines have been identified and many can bind to more than one receptor. In addition, about half of the 20 chemokine receptors, which are 7-transmembrane G-protein coupled receptors (GPCRs), recognize multiple chemokines. Which chemokine or receptor to block in a particular disease remains a difficult question, and targeting individual chemokines has not been fruitful due to redundancy in the system.
On the other hand, blocking GPCR chemokine receptors by synthesizing small-molecule inhibitors that block the interaction of multiple chemokines with an individual receptor has been more encouraging. The chemokine/receptor pairs CXCL13/CXCR5, CCL21/CCR7, and CXCL12/CXCR4 contribute to the formation of ectopic lymphoid structures that are found in most autoimmune diseases and could be targeted for autoimmunity. CCR5, CCR2, and CCR1 are implicated in RA and might be involved in recruitment to inflammatory sites like synovium.
Inhibition of CCR1 and CCR2 was not effective in RA . The results for the CCR1 antagonist were somewhat surprising in light of a synovial biopsy study suggesting that synovial macrophages were depleted. CCR2 is a more complex chemokine, and the effect of CCR2 deficiency or CCR2 inhibitors in animal models varies depending on the model. This approach is especially interesting in humans because CCR2 (along with CCR6) is a key receptor expressed by human Th17 cells . The failure of CCR1 and CCR2 antagonists could be related to pharmacokinetic issues, lack of pathological relevance of these targets, or redundancy in the receptor system.
CCR5 received considerable attention when it was discovered that individuals with a deletion in this gene are protected from HIV viral entry. Epidemiologic studies also suggest that the CCR5 deletion could decrease severity of RA, although this is controversial. A small-molecule inhibitor of CCR5 is now approved for patients with HIV. CCR5 is expressed on T cells and macrophages and binds to the inflammatory chemokines MIP-1α (macrophage inflammatory protein-1-alpha) and RANTES (regulated on activation normal T cell expressed and secreted) that are highly expressed in RA. Blocking CCR5 provides protection from arthritis in the CIA model . Phase II clinical trials with CCR5 inhibitors are in progress for RA.
Many other chemokines have been considered targets for rheumatic diseases. For instance, stromal derived factor-1 is a potential target and is relatively simple to block since, unlike many other chemokines, it has only a single receptor (CXCR4). Chemokines play a role in the organization of lymphoid structures, which are required for antigen presentation and germinal center formation. Disrupting this network by interfering with dendritic cell-derived chemokines, such as CXCL13 or CCL21, could achieve this goal, as could blocking cytokines like LTβ (see above).
A detailed description of the myriad of approaches designed to interfere with immune cell recruitment by blocking either cell adhesion or angiogenesis is beyond the scope of this short review. However, the success of the anti-α4/β1 integrin antibody in multiple sclerosis suggests that it might be useful in other autoimmune diseases that involve recruitment of T cells. Balancing the relative risks of decreased host defense (for example, progressive multifocal leukoencephalopathy [PML]) with potential benefit will be a significant challenge. Approaches that target the β2 integrins, which play a key role in neutrophil recruitment, are very effective in preclinical models but raise significant concerns about crippling host defense. Similarly, angiogenesis inhibitors like anti-vascular endothelial growth factor in cancer and preclinical data suggesting that new blood vessels contribute to inflammation suggest that this approach might be applicable to rheumatic diseases. Selective inhibitors of proliferating endothelial cells, such as AGM-1477 (a derivative of fumagillin), show impressive anti-inflammatory effects in several animal models of inflammatory arthritis.
The efficacy of rituximab, a chimeric anti-CD20 monoclonal antibody, in RA opened up the potential for B cell-directed therapy in rheumatic diseases. The antibody was initially developed to deplete malignant B cells in lymphoma patients by virtue of CD20 expression on mature B cells, but not B-cell precursors or plasma cells. Rituximab causes a prolonged depletion in circulating B lymphocytes in the blood. CD20+ synovial B cells are variably reduced and this is associated with a decrease in synovial immunoglobulin synthesis, especially in ACR50 responders . Clinical response was associated with a decrease in synovial plasma cells in another study .
Rituximab contains chimeric mouse-human sequences that might be responsible for some infusion reactions. Human or humanized anti-CD20 antibodies, like ocrelizumab and ofatumumab, are being developed to mitigate this problem . Smaller versions of monoclonal antibodies combine one binding domain, one hinge domain, and one effector domain into a single-chain polypeptide. This new class of drug, known under the acronym SMIP (small modular immuno-pharmaceutical), is also being developed.
Although multiple case reports and open-label studies suggested a benefit of rituximab in SLE patients, the drug did not demonstrate clinical efficacy in the randomized phase II/III EXPLORER trial. The results of another study for lupus nephritis are anticipated. Case reports of fatal PML in severely immunocompromised lupus and cancer patients who received anti-CD20 antibody necessitate careful individual evaluation of the risks and benefits of off-label use.
CD22 is a B cell-specific surface molecule involved in B-cell antigen receptor signaling. A humanized antibody against this regulatory molecule showed modest efficacy in lupus patients in a randomized phase II study . An average reduction of peripheral B cells of 30% can persist up to 12 weeks. Additional regulatory mechanisms, including inhibition of B-cell proliferation, could contribute to the therapeutic activity of this molecule.
CTLA4 is an inducible T-cell surface molecule that inhibits costimulation signaling induced by CD28 engagement with CD80/CD86. Abatacept, a CTLA4-Ig fusion molecule, blocks the interaction between CD80/86 and CD28 and is effective in RA. The success of this approach contrasts with the failure of previous T cell-depleting strategies, such as anti-CD4 antibodies, perhaps because CD4 is also expressed on Treg cells that can suppress inflammatory arthritis.
Other costimulatory molecules are also potential therapeutic targets, although the preclinical data are complex. For instance, blockade of the inducible costimulator (ICOS) is therapeutic in CIA but augments disease in diabetes and some multiple sclerosis models . Subtle differences between human and animal proteins, such as Fc receptors, might contribute to the catastrophic cytokine release syndrome caused in human volunteers by the CD28 superagonist TGN1412 . Nonetheless, the CD80/86-CD28 family remains a promising field for new therapeutic interventions. The interaction between CD40 and CD40 ligand is also attractive, although anti-CD40 ligand antibodies in SLE were complicated by thrombotic disease. Targeting CD40 instead might avoid the activation of platelets, which express CD40 ligand.
FLS are present on the synovial intimal lining. They contribute to the pathogenesis of RA by virtue of their ability to produce cytokines (especially IL-6), metalloproteinases, and small-molecule mediators of inflammation like prostaglandins. Selective targeting of FLS has been difficult until recently, when a relatively unique marker, cadherin-11, was identified as a key protein involved with homoaggregation of synoviocytes in the lining layer of normal synovium . Preclinical models suggest that cadherin-11 blockade disrupts the synovial lining, decreases joint inflammation, and suppresses cartilage damage. This approach is interesting because it could potentially be used in combination with immunomodulatory agents without an adverse effect on host defense.
Inducing or enhancing synovial cell death, especially FLS, is another approach that could be beneficial in inflammatory arthritis. A number of therapies have been considered and demonstrate preclinical efficacy, including using anti-Fas antibodies to induce apoptosis or enhancing expression of intracellular genes like Bim or PUMA (p53 upregulated modulator of apoptosis) [35, 36]. Because the mechanisms of cell death are shared by many cell types, selectively inducing apoptosis in FLS or in the joint can be difficult. Thus, methods to target the synovium selectively might be required.
Intracellular signaling pathways transmit environmental information to the cytoplasm and the nucleus, where they regulate cellular responses and gene transcription. Understanding the hierarchy and pathogenic significance of these pathways in autoimmunity has led to the development of compounds that block several promising targets [37, 38]. Orally bioavailable small-molecule inhibitors are currently the most likely approach, although biologics like small interfering RNA and genes that express dominant negative kinases are also possible. It is likely that the small-molecule approach, though still in its infancy, will advance rapidly over the next decade. If successful, these small compounds could augment or replace more expensive parenteral biologics that are currently the mainstay of treatment. Several hurdles still need to be overcome, including improved compound specificity and the importance of many key pathways for homeostasis and host defense .
Mitogen-activated protein (MAP) kinases are stress-activated serine/threonine kinases that include the p38, ERK (extra-cellular regulating kinase), and JNK (c-Jun-N-terminal kinase) (Figure 2) families. This complex family regulates both cyto-kine production and cytokine responses in a variety of rheumatic diseases. Partially overlapping activation signals converge on each kinase pathway, which in turn regulate a number of downstream events such as transcription factor activation, cell migration, and proliferation .
The mitogen-activated protein kinase (MAPK) signaling cascade. The MAPKs form an interacting cascade of signaling enzymes that orchestrate responses to extracellular stress, such as inflammation, infection, and tissue damage. The three main families (ERK, JNK, and p38) have overlapping functions but tend to regulate cell growth, matrix turnover, and cytokine production, respectively. The cascade generally has three levels (shown on the left), including the MAP kinase kinase kinases (MAP3Ks), which activate the MAP kinase kinases (MAPKKs or MKKs), which, in turn, activate the MAPKs. Drug development efforts thus far have focused on p38 and MEK1/2 for rheumatic diseases. JNK inhibitors are effective in preclinical models and are also being developed for cancer. ATF2, activating transcription factor-2; ERK, extracellular signal related kinases; JNK, c-Jun N-terminal kinase; MAPKAPK, mitogen-activated protein kinase-activated protein kinase; MEK1/2, mitogen-activated protein kinase kinases.
Drug development efforts in the MAP kinase family have led to the synthesis of several p38 inhibitors. This kinase regulates the production of inflammatory cytokines and chemo-kines in response to TNF or IL-1 in most inflammatory cell types. p38 inhibitors are effective in preclinical models of arthritis and several have advanced into clinical trials [39, 40]. The availability of phase II trial results in RA is limited but they suggest, at best, modest benefit in RA. One major issue that affects the development of some p38 inhibitors is dose-dependent toxicity. Structurally distinct compounds have caused hepatoxicity, which might indicate that this side effect is target-based. In another phase II trial, the p38 inhibitor VX-702 caused Q-T prolongation.
Based on the number of compounds that have been tested, it is clear that targeting p38 will not be as simple as hoped. Several potential alternatives have emerged in recent years, including downstream (MK2) or upstream (MKK3 or MKK6) kinases that are involved in the p38 biology [41, 42]. These strategies could potentially provide some of the benefit of modulating p38 signaling while preserving other essential functions and ameliorate the side-effect profile.
JNK and ERK inhibitors for rheumatic disease are less advanced. JNK controls activator protein-1 (AP-1)-dependent genes, including matrix metalloproteinases (MMPs), and animal studies with JNK inhibitors showed protection from bone damage . However, the available JNK inhibitors have not been developed for rheumatic diseases yet and could have issues related to potency and selectivity. MKK7, an upstream activator of JNK, is the main kinase required for JNK activation after cytokine stimulation of FLS . Since cellular stress events can bypass MKK7 and use MKK4 to stimulate JNK, targeting MKK7 could be safer than broad-acting JNK inhibitors.
Targeting the downstream transcription complex AP-1, such as with decoy oligonucleotides, is another alternative to focusing on JNK. AP-1 consists of dimers that include members of the Jun, Fos, and activating transcription factor protein families that together control a large number of genes, including MMPs and inflammatory cytokines. c-Fos-deficient mice lack osteoclasts and are protected from bone erosions but not inflammation in the TNF transgenic model . A small molecule with anti-AP-1 activity was effective in CIA . Interestingly, this compound also decreased IL-1 levels and joint inflammation, an indication that it had a pronounced effect on AP-1-driven transcription. No significant toxicity was reported during animal testing but this will require careful evaluation in human studies.
ERK plays a major role in the regulation of cell growth and could be an important therapeutic advance in cancer. ERK inhibitors are also effective in some preclinical models of arthritis . The small-molecule inhibitor MEK1/2 (ARRY-162), which is the upstream kinase that regulates ERK, inhibits ex vivo production of IL-1, TNF, and IL-6 by human whole blood after administration to healthy volunteers . Similar to other MAP pathway inhibitors, however, toxicities (including skin rash and visual changes) have emerged due to the ubiquitous role of ERK. It might be more desirable to modulate, rather than block, these pathways by careful selection of pharmacokinetic profiles and judicious dosing.
Tyrosine kinases are divided into two groups. Cytoplasmic kinases transduce signals from a separate surface receptor while receptor tyrosine kinases have intrinsic tyrosine phosphorylation activity. The four Janus kinases (JAKs) are cytoplasmic tyrosine kinases that pair in at least six different combinations to integrate signaling from nearly 40 different cytokines and growth factors . Cytokine receptors that comprise the common γ-chain subunit use JAK1 and JAK3 to respond to cytokines involved in RA, such as IL-6, IL-2, IL-12, or IL-15. JAKs then activate STAT proteins that translocate to the nucleus and control the expression of downstream targets.
Selective inhibitors of JAK are now in clinical studies for the treatment of RA and psoriasis . The small molecule CP-690,550 inhibits JAK3, with less inhibition of JAK1 and JAK2. JAK3, which is mainly expressed in hematopoietic cells, pairs with JAK1 and signals downstream of IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21 . Initially developed as an immuno-suppressive, the compound demonstrated clinical efficacy in an early phase II trial with excellent ACR responses: CP-690,550 ACR50 33% to 54% versus placebo ACR50 6% . Mechanism-based side effects were observed, including in the hematopoietic system. Neutropenia was reported at the highest dose. As a T-cell immunomodulator, this compound could have utility in a variety of autoimmune diseases assuming that the safety profile permits further development.
INCB018424, an inhibitor of JAK1, JAK2, and Tyk2 with IC50 (half inhibitory concentration) values of 2.7, 4.5, and 19 nM, respectively, is also in clinical development for RA and psoriasis. This inhibitor could indirectly affect JAK3, which needs to pair with JAK1 for most of its effects . Tyk2 mediates type I IFN, IL-12, and IL-23 signaling . A preliminary study that enrolled six active RA patients during 28 days showed a favorable clinical outcome without significant adverse events, using a controlled dosage to inhibit JAK1 and JAK2 but not Tyk2. The long-term safety of this powerful immunosuppressive approach must be carefully evaluated. The known complications of severe immuno-deficiency in humans bearing JAK mutations suggest that the development will need to be cautious.
Spleen tyrosine kinase (Syk) also belongs to the intracellular tyrosine kinase family. Syk is expressed in B cells, mast cells, neutrophils, macrophages, platelets, and nonhematopoietic cells, including FLS. The molecular signaling events in the Syk cascade are best defined in hematopoietic cells. Syk binds to phosphorylated activated ITAMs (immunoreceptor tyrosine-based activation motifs) that are part of immuno-receptors such as the B-cell receptor, T-cell receptor, or FcR. ITAM-Syk signaling is also triggered by integrins during cell adhesion and migration via ITAM-dependent or -independent mechanisms .
Less is known about Syk signaling pathways in nonhemato-poietic cells. ITAM consensus motifs are found in a number of molecules unrelated to classical immunoreceptors, and ITAM-independent mechanisms could also be engaged . In synovial fibroblasts, Syk regulates the MAP kinase cascade, especially JNK-regulated genes such as IL-6 and MMP-3 . Syk inhibition was able to suppress inflammation and joint destruction in a rat CIA model . Treatment with tamatinib fosdium (R788), an oral Syk inhibitor, led to significant improvement in RA patients . Syk is also an interesting target in SLE, in which part of the overactive T-cell phenotype is thought to be caused by the abnormal association of Syk with the T-cell receptor instead of the ζ chain Zap70. A Syk inhibitor was therapeutic and preventive in a model of murine renal lupus .
Imatinib mesylate was the first successful clinical application of a therapeutic designed to target tyrosine kinases. It is currently approved for several oncologic indications, including chronic myelogenous leukemia and systemic masto-cytosis. Imatinib is a potent inhibitor of platelet-derived growth factor (PDGF) receptor, c-kit (the receptor for stem cell factor, a growth factor for hematopoietic cells and mast cells), and the proto-oncogene c-Abl. Thus, the compound inhibits a spectrum of signal induction pathways relevant to inflammation and fibrosis, including PDGF signaling in synoviocytes, mast cell c-kit signaling, and TNF production by synovial fluid mononuclear cells. Imatinib is active in murine CIA, supporting its development in inflammatory arthritis . Case reports indicate that it might be beneficial in refractory cases of RA, but the results of a controlled study have not been reported .
c-Abl also can participate in the profibrotic effects of TGF-β signaling. For instance, patients receiving imatinib for chronic myelogenous leukemia experienced marked improvement in myelofibrosis . Several studies in animal models and clinical case reports in various conditions confirm that imatinib is a promising therapeutic for fibrotic disorders such as scleroderma, pulmonary fibrosis, or nephrogenic systemic fibrosis [62, 63].
Both benefits and side effects of kinase inhibitors are often observed because of structural similarities between enzymes, especially in the ATP site where most small compounds bind. Lack of selectivity might provide a therapeutic advantage in complex diseases such as RA, in which more than one molecular pathway contribute to the pathogenesis. On the other hand, it also increases the risk of side effects. Long-term studies of imatinib for the treatment of cancer patients show that severe adverse events occur in more than a third of patients, mostly within the first 2 years . Therefore, careful risk-benefit analysis will be required for all of these new kinase inhibitors.
Several phosphatidylinositol 3-kinase (PI3K) inhibitors have entered clinical trials in different fields, including oncology, cardiology, and autoimmunity. Class I PI3Ks are a family of intracellular signaling proteins involved in many aspects of cell biology, including adaptive and innate immunity . They are composed of heterodimers assembled from five different regulatory subunits that pair with four different catalytic subunits (α, β, γ, and δ). Activation of PI3Ks generates the key lipid second messenger phosphatidylinositol (3,4,5)-trisphosphate (PIP3). The α, β, and δ subunits are associated mainly with receptor tyrosine kinases, whereas γ subunits signal to GPCRs such as chemokine receptors. This dichotomy is not absolute and there are additional specificities depending on the cell type examined.
PI3Kα and β are expressed in most cell types, which is, in part, why cancer has been a primary drug development pathway. PI3Kδ and γ are present mainly in hematopoietic cells, suggesting that they will be better targets for therapeutic intervention in autoimmune diseases . Mice lacking PI3Kγ have altered signaling in T cells, macrophages, neutrophils, and mast cells. This particular kinase is a key convergence point for many chemokine receptors. Therefore, a PI3Kγ inhibitor could potentially block chemokine function more effectively than targeting individual receptors. PI3Kδ-deficient mice have more subtle defects in neutrophil signaling and T-cell activation but have impaired B-cell functions. Interestingly, migration to the bacterial product fMLP (N-formyl-methionyl-leucyl-phenylalanine) remains intact in PI3Kδ-deficient cells while it is impaired after PI3Kγ blockade. Preclinical data show that PI3Kδ and γ inhibition can decrease the severity of arthritis either separately or in combination, the latter leading to a synergistic effect [67, 68]. In addition, PI3Kγ deficiency decreases disease activity in murine lupus models .
The array of potential therapeutic targets described above is impressive but still represents only a small part of the spectrum (Table 1). There are many other therapeutic targets with great potential merit, and space limitations prevent a detailed discussion of each one. This cornucopia of targets includes other approaches that can modulate cytokines (for example, adenosine A3 receptors), proteases (for example, collagenases), ion channels (for example, P2X7 receptor), and innate immune responses (for example, IFNs and Toll-like receptors). Time will tell whether one of these pathways or the ones described in more detail above will lead the way to the next generation of therapeutics. Identifying possible targets is no longer the major hurdle; rather, prioritizing potential drugs among limited patient populations, using novel study designs in an era when placebo-controlled studies have become increasingly difficult, and using genomic and biomarker data to predict clinical response and toxicity are key issues that will need to be addressed. Nevertheless, our new molecular understanding of human disease will likely lead to a pipeline of breakthrough therapies over the coming years that will improve survival and quality of life for our patients.
Completed phase III in RA. Phase III for sJIA.
Insufficient efficacy in phase II (RA).
Phase I in RA, psoriasis, and others.
Phase II for psoriatic arthritis.
Lack of efficacy in RA. Phase III in SLE.
Lack of efficacy in RA for LTβ (phase II).
Phase II in RA, SLE.
Decreased erosions in RA (phase II).
Phase I/II in RA and transplant.
Phase II in RA, ankylosing spondylitis, Crohn disease, and other inflammatory diseases.
Phase II in RA and scleroderma.
Many other compounds and targets not listed are also being evaluated. Suffixes: -cept, receptor-antibody fusion protein; -umab, human monoclonal antibody; -zumab, humanized monoclonal antibody. APRIL, a proliferation-inducing ligand; BAFF, B-cell activation factor of the tumor necrosis factor family; BLyS, B-lymphocyte stimulator; ERK, extracellular regulating kinase; GPCR, G-protein coupled receptor; IL, interleukin; JAK, Janus kinase; LIGHT, lymphotoxin-related inducible ligand that competes for glycoprotein D binding to herpes virus entry mediator on T cells; LT, lymphotoxin; mAb, monoclonal (therapeutic) antibody; MEK, mitogen-activated protein kinase; P13K, phosphatidylinositol 3-kinase; PDGF-R, platelet-derived growth factor receptor; RA, rheumatoid arthritis; RANKL, receptor activator of nuclear factor-kappa B ligand; sJIA, systemic juvenile idiopathic arthritis; SLE, systemic lupus erythematosus; SMIP, small modular immunopharmaceutical; Syk, spleen tyrosine kinase.
Supported in part by NIH grants AI067752, AI070555, and AR47825. | 2019-04-23T06:37:47Z | https://arthritis-research.biomedcentral.com/articles/10.1186/ar2556 |
It’s never too early to help a family member build their own retirement nest egg.
Summer usually finds teens and college students working at summer jobs, and for many, proudly pocketing their first earnings. But an interesting perspective comes from Kiplinger Retirement Report, as explained in “Seed a Roth IRA for Your Grandkids,” that grandparents can use summer earnings as a teachable moment about retirement planning. Grandparents can make contributions to a Roth IRA for their grandchildren, who can use those funds in later years to build retirement income or even purchase a home.
As an illustration, if you were to contribute $2,000 a year over four years beginning when a grandchild is 15—with a modest 6% annual rate of return—those contributions will grow to more than $143,000 by the time the grandchild is age 66.
Until your grandchild turns 18 or 21, and depending on the laws of your state, you’ll be able to control the money, and then your grandchild will be able to use it, however he or she wants.
If you have a relative who refuses to create a will, then you may have front row seats to a similar process as Prince’s heirs, even if it’s not on such a grand scale. It took months to identify the heirs and figure out how to pay a huge tax bill.
The business side of Prince’s estate is now taking center stage, as the probate mess that resulted from the visionary artist’s failure to create an estate plan has moved forward. It’s time to monetize an extraordinary legacy.
Many entrepreneurs and business owners do the same thing as Prince. They place a high value on their own talent and can’t imagine how their businesses will continue without them. Therefore, they avoid having a will or estate plan created. Family members and the courts are left to clean up the complexities. Don’t be like Prince. Work with an experienced estate planning attorney to create a will and make a plan for a world without you in it.
To learn more about the importance of establishing a last will, please visit our website.
There’s no need to wait until you retire to be more proactive about managing your retirement accounts. In fact, there are a few steps you can take, including using an “in-service rollover” while you are still working.
The days when Americans worked for a single company for a lifetime and received a guaranteed pension for life are long gone. The burden of managing and maximizing retirement funds is now squarely on the shoulders of the employee themselves. Instead of a pension, employees have retirement accounts, typically 401(k)s.
With no guarantees, it’s critical that employees be financially savvy about managing their retirement accounts and making informed strategic decisions to achieve a comfortable and successful retirement. | 2019-04-19T22:29:57Z | https://blog.elderlaw-va.com/asset-protection/ |
A nice concept underlying this 12 "vinyl - to use the 0.7 millisecond sound recorded by then anonymous Scottish art collective DISKONO and transpose it into this orchestrated two trakcs of concrete synthesis.
Realtime tape manipulations, turntable and samples and synthesizer all together in great alchemical soup which seems to be sizzling with micro-soundscape. Two tracks on a vinyl and great musicians like Felix Kubin known from his retro emploi of a synth puppeteer, Larry Seven who usually deals with multimedia installations and Scott Haggart experimenting here in a turntablistic manner.
It wasn't supposed to be just another live meeting tuned out to be really involving and edgy experience. | 2019-04-18T18:25:33Z | http://felthatreviews.blogspot.com/2014/11/scott-haggartlary-sevenfelix-kubin-117.html |
The Politwoops API allows you to request info from our application. This page explains how you can communicate with our API.
The API for politwoops is really simple. No authentication is required (yet?). We will monitor access however, so don't abuse it. Also note that Politwoops is not hosted on a big server, so please be polite and leave 1 second between API requests.
Note that the details field in the tweet if the original object as we received it from Twitter. The API call has one parameter (page) which controls pagination.
You can get a list of politicians by fetching the URL https://www.politwoops.(nl|com|us|eu)/politicians.json. The end-result is in JSON format. The response is capped at 50 politicians, again you can use the pagination (page) that starts at 1 (as of September 2018 we have up to 358 pages), if no page parameter is supplied page=1 is used as default. Another optional parameter is the group_id to filter on a certain group of users (e.g. a country group), see Group notes.
You can get a list of politicial parties by fetching the URL https://www.politwoops.(nl|com|us|eu)/parties.json. The end-result is in JSON format.
You can get a list of groups by fetching the URL https://www.politwoops(nl|com|us|eu)l/groups.json. The end-result is in JSON format. The country groups are located at https://www.politwoops(nl|com|us|eu)l/countries.json.
full_name: "De gemeenteraad van aa en hunze" | 2019-04-26T12:34:51Z | https://politwoops.co.uk/page/api |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.