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When a doctor makes an error in diagnosing and treating an illness, it raises a lot of questions. The situation can become worse if a patient is seriously hurt or suffers serious side effects during treatment. There are instances when the question of medical malpractice can be raised; however, you need to determine if there is any evidence that points to such a situation.
The doctor should have treated the patient. This treatment should include diagnosis, treatment, and even failure to treat based on set medical standards.
The doctor’s treatment should have presented quantifiable harm to the patient as a result of negligence. If you find evidence that this took place and the harm is provable, you could hire a lawyer to help you prove your case. You could hire another doctor to prove that care was not up to expectations, even though a doctor might have met the “standards of care”.
If you are considering filing a case, you can talk to a lawyer who specializes in medical malpractice. Most lawyers will take a case based on its merits and a contingency basis. There are some questions that you should ask, besides just the fee structure.
If I get treated in another state, can I still file a case in my home state?
Is there a time limit for filing a lawsuit?
What can I do if I realize the mistakes made by my caregiver years after my treatment?
Medical malpractice is a traumatic event for the patients and their families. Malpractice cases can be hard to prove as well, so it is important to get a lawyer with lots of experience in this field. | 2019-04-24T05:59:14Z | http://www.primeadvantagelegal.com/medical-malpractice-know-if-you-have-a-case/ |
The hexadecimal color code #407c78 is a medium dark shade of cyan. In the RGB color model #407c78 is comprised of 25.1% red, 48.63% green and 47.06% blue. In the HSL color space #407c78 has a hue of 176° (degrees), 32% saturation and 37% lightness. This color has an approximate wavelength of 493.24 nm. | 2019-04-22T22:02:24Z | https://encycolorpedia.com/407c78 |
If you are business who is highly concerned about the commercial security, then calm your nerves! Transfer all your lock and key worries to South Houston TX Locksmiths Store and we will take care of it all. Right from fixing the locks to installing new ones for various areas within your premise, we can do it all in the most precise manner. Whether your requirement is the manual conventional padlock or the highly efficient digital lock designed for tech-savvy firms, we can get it all installed at your place!
No matter what type of business you own in South Houston, TX area, retail or wholesale, we have got the right locks for all kinds of commercial premises. Paying attention to your security requirements and budget, we would design the most appropriate security solution just for you. Our commercial locksmith store is stocked to suffice the needs of all and our locksmiths are right behind their wheels to help out everyone out there!
Security accessories – At South Houston TX Locksmiths Store, we have a wide-range of security products to choose from. Visit our store to get the ones that suits you the best!
It is highly imperative to have a top-notch security system for your commercial premise. Get it all today from the commercial locksmith store of South Houston TX Locksmiths Store. Visit us or call us at 713-714-4261! | 2019-04-20T08:31:34Z | http://southhouston.texas-locksmiths-store.com/commercial-locksmith-store.html |
You have found my site! Yay. Lets get working together. I am a National Academy of Sports Medicine Certified Personal Trainer and Group Fitness Instructor located in the South Suburbs of Chicago. I also offer online programs as well. Can’t wait to work out with you. | 2019-04-23T08:13:47Z | https://fitnesswithrose.com/2015/06/ |
Ah, finally! It was Charlotte’s turn this week to take the spotlight on this Private Practice Season 6 installment.
I’ve been sitting tight and anxiously waiting for the focus to be on KaDee Strickland’s Charlotte King, as we’re winding down on the final run of this outstanding drama. And it definitely did not disappoint.
I’ve said it numerous times before, and I’m saying it once again: Shonda and company, please consider a spinoff featuring the Freedman family! Charlotte was absolutely spectacular. She was vivacious, over-the-top, and kept me laughing throughout the night. By the way, how amazing did she look in all of the dance sequences? I bet filming those scenes was a blast.
"Georgia On My Mind" focused on Charlotte, who continued to run Saint Ambrose Hospital from her doctor-ordered bed rest. At a first glance, I was thinking: seriously, Charlotte?!?
However, I couldn’t have imagined her any other way. She’s a control freak and with her thoughts so loud, it was easy to feel and see how difficult a time she was having.
Her frustrations and uncomforting position were more than she could handle. They were, in fact, more than she had ever asked for, as she drove the nurses crazy. Luckily, Stephanie was back to give her a reality check and tell her that she didn’t care if she was fired because no one else would be willing to help Charlotte. Simply put, our girl just needed to hang in there and chill a bit with the call button.
I couldn’t help but feel incredibly sad as Charlotte started to regret once hoping for a miscarriage. She cried out and wanted her life – instead of one of the triplets – to be taken if need be. It was truly a heartbreaking scene. Even more distressing was seeing “Sissy” struggling throughout the installment. Thanks to Addie, Sam and Amelia, “Sissy” was all right in the end, named Georgia and seen by her mom.
Elsewhere, Mason began acting out in school because he was scared that Charlotte might never leave the hospital. Could you blame the little guy? After losing his mother recently and considering Charlotte’s pregnancy complications, it was no wonder he was having such a hard time dealing with everything.
We saw CharCoop argue over whether not Mason should be punished. Each were pushed to his/her limits with a very intense argument. Ultimately, we were reminded that they need one another and make one heck of a team. I'm going to miss them terribly once all’s done and said.
Hey, Dancing with the Stars, I think you should call up Paul Adelstein and KaDee Strickland. Those breakout dancing moments were awesome. So much fun to watch.
I laughed out loud when Charlotte threw her stress ball at the “choir reject Christmas carolers.” She’s absolutely hilarious!
I was surprised Charlotte didn’t end up smashing a cupcake in Violet’s face during the non-shower shower. How about you?
Sam and Stephanie are giving it a go again. Did anyone see this coming?
I thought this installment was remarkably well done and loved that we closed out this year in such a strong way.
We won’t see our favorite doctors again until 2013 when they’ll return to wrap up Private Practice Season 6. Until then, be sure to hit the comments because I’d love to hear your thoughts on tonight’s final episode of the year as well as what you’d like to see happen in the final three installments. Also, don’t forget to return later this week for our Private Practice Round Table. | 2019-04-23T05:54:19Z | https://www.tvfanatic.com/2012/12/private-practice-review-a-lot-like-charlotte/ |
The beginning of this generation was a disaster for NHL. Already a year late to the party, it launched with underwhelming additions and missing features, most notably its flagship mode the EA Sports Hockey League. But after five years NHL appears to have turned things around, and in a big way.
NHL 19 finally brings much-needed improvements to the skating via the Real Player Motion or "RPM" tech, making carves and crossovers feel more realistic and responsive. It also includes a physical overhaul that makes players feel bigger and nastier without being cartoony. Players will anticipate and follow through on their hits, giving them a satisfying punch.
It's already a nice step over last year, which felt dated at times. In NHL 18 players wouldn't so much skate as sort of float across the ice; hits were either too soft or ridiculously hard, and defensive AI was eminently exploitable. NHL has made several improvements to the gameplay over the years, but until now the locomotion has always been fundamentally the same. It's a relief to see some much-needed improvements to the foundational gameplay, and the difference is noticeable when playing.
This is on top of the strong improvements NHL has managed to make elsewhere. Where FIFA, Madden, and the rest have chosen to focus on narrative experiences and Ultimate Team, last year's edition of NHL put its resources into the team-based EASHL and arcade modes like NHL Threes. It also made notable strides in the franchise mode department, adding much-requested features like custom teams, expansion, and custom leagues.
NHL remains one of the two EA sports franchises to delay the transition to Frostbite, but even that is perhaps to NHL's benefit, as FIFA in particular has experienced only marginal gains while struggling with optimization issues. NHL producer Sean Ramjasingh says of the Frostbite Engine, "We're still evaluating. It's not easy getting on a new engine, it's kind of like a console transition. We're monitoring FIFA and Madden and learning about the successes and challenges they've had."
In the meantime, NHL has grown into a solid, well-rounded sports sim. And with improvements to the player movement and physics, it stands to finally make serious leaps in the gameplay department as well.
But that's just the beginning for NHL 19. In an effort to build more of a persistent online platform (I know), EA is introducing "World of Chel," which will allow you to customize your avatar with some 900 customization items, including hoodies, parks, and hats. It feels a bit like a cross between NBA 2K's MyPark and Forza Horizon's festivals, with DJs and scenic resorts like Whistler giving its environments a party vibe that is often absent in EA's normally sterile sports sims.
The look is meant to pull in fans who aren't necessarily into the NHL, Ramjasingh says. "There are some players who don't relate to the league, but love hockey."
One of the new modes within "World of Chel" (forgive me, I'm still struggling with the name a bit) is NHL Pro-Am—a series of challenges inspired by outdoor pond hockey. It also includes Ones, a new free-for-all mode in which three players battle to steal the puck and score. It doesn't sound like much, but it's a surprisingly fun and chaotic way to showcase your individual skills as you avoid your opponents and try to score. If one players gets too far ahead in the points tally, the other two can gang up on them. Games take place in picturesque locations like the Rocky Mountains, with players wearing their individualized outfits.
NHL may not feature the Winter Classic, but it's still taking its game outside.
In introducing these elements, it's clear that NHL is shooting for something akin to NBA 2K. But Ramjasingh says there will be no in-game microtransactions. "Nothing is monetized because we want it to be diverse."
Sadly, these cool outfits don't translate into EASHL, which strikes me as an odd choice. Ramjasingh says that he wants to retain the unified league feel of the mode, but it risks making the outfits feel superfluous. It will ultimately depend on how expansive "World of Chel" (god, it's just the worst) ends up feeling.
NHL Ones is structured somewhat like Clash Royale. If you win, you'll be promoted to upper tiers. If you lose, you'll be demoted. Each new tier is represented by a different rink, culminating in a nighttime vista in British Columbia's Whistler resort.
In addition to cosmetics, NHL 19 will include trait and specialization loadouts. Some of the abilities include "Booming Slappers," "Dirty Dangles," and "Tight Turns."
NHL 19 will feature 200 alumnia players including Wayne Gretzky. Even better, they're finally being set free from Hockey Ultimate Team. They will be available in multiple modes including franchide. Yes, I am putting Wayne Gretzky on the Minnesota North Stars, thanks for asking.
This year's cover athlete is P.K. Subban, which is a fine choice. Of course I would have picked Alex Ovechkin doing a keg stand out of the Stanley Cup, but that's just me.
All told I really like where NHL is going right now. Where other sports sims are dour esports wannabes or straight-up microtransaction machines, NHL is embracing its arcade roots in a way that I find refreshing. Its franchise and online team modes are second only to NBA 2K right now (lack of the Winter Classic aside); and if it gets the gameplay right, it may well be my favorite sports sim of the year. Who needs Alex Hunter and the Frostbite Engine, am I right?
So after a mostly forgettable generation, NHL finally seems to have some momentum. Now if EA will only just bringing back online franchise mode, I'll be ready to call it my game of the year. NHL 19 will release on Xbox One and PS4 on September 14.
Tagged with Analyses, Electronic Arts, PlayStation 4, Sports, Xbox One. | 2019-04-22T08:00:58Z | https://www.usgamer.net/articles/nhl-19-hands-on-review |
This men's Bulova watch from the Automatic Collection features a new sport style in gunmetal with ion-plated stainless steel case, open aperture black dial with silver-tone accents and black inner dial ring. The watch features an exhibition case back, skeleton automatic movement with 40-hour power reserve and a protectant sapphire glass. The gunmetal IP stainless steel bracelet opens with double-press deployant closure and is water resistance to 100 meters. | 2019-04-23T02:52:55Z | https://www.donrobertojewelers.com/watches/men-s-bulova-gunmetal-classic-automatic-watch-98a179 |
I want to make personalised products.How does a client upload their photo up onto the product?
The process for getting FPD installed is easy, though the settings are kind of convoluded. There are some support videos where you can watch them create a product, or better yet, you can upload one of their sample products and play with the settings to see what the settings do. took me many days worth of work to get the whole things down. Now I have this and I am very proud of it.
Loving your CSS tweaks to the UI #Jeremiah Very nice and clean.
We have launched our site, and thanks for Radykal and their attention to detail and upgrading (kudos guys for all the hard work) it is working well. I am still trying to test out integrating multistage product builder plugin from Radykal, but the problem we have is most orders are online, and the tabs are almost always off screen so you choose your color disc, then choose your insert and must scroll between each time changing the insert to see what it looks like. Would be nice to have a slider option within the stage where you can scroll through with a little thumbnail slider within the view pane and even have some arrows left and right to just arrow through the choices instead of clicking.
Don't forget, if you change the CSS, do it in your main style sheet. I did it in the FPD files, and it was a) incredibly difficult to wade through, and b) will get removed when updating. So save yourself the headache and edit CSS sit wide for the fpd classes. | 2019-04-22T23:04:34Z | https://support.fancyproductdesigner.com/support/discussions/topics/5000046736 |
Find the best business class flight and luxury hotel deals for Black Friday and Cyber Monday 2018. We will update this page constantly during the end of November 2018, so be sure to come back from time to time for the best offers.
The best Black Friday will disappear quickly, so make sure you don’t miss any of them by following us on Twitter (@alwaysflybiz) and Facebook.
This year British Airways deals are focused around two people traveling. You can find plenty of business class deals from London to for example Las Vegas, Nashville or San Francisco.
Example: December 26th – December 31st, London – Las Vegas return in Boeing 777 business class, for two (2) people, starting from 2193 EUR (about 2000 GBP). Check the offer through Google Flights.
Finnair has only few semi-decent business class deals available, among the best is a return flight from London to Phuket for 1701 EUR.
Qatar Airway’s Black Friday offering looks quite sad so far, with only few decent exEU deals. Their highlight seems to be “4x Qmiles in Business or First Class, exclusively when booking at qatarairways.com during the offer period”. Book by 27 November 2018 for travel until 31 July 2019.
The second deal is from Oslo, Norway or Stockholm, Sweden to Auckland, Zew Zealand for 2271 EUR. There are more similar deals to Australia as well.
Save 100 GBP per booking when flying in Economy Classic or Economy Delight – or save 150 GBP when flying in Premium. Minimum spend 1200 GBP.
Hilton has a BLACK FRIDAY sale on selected hotels in Japan, South Korea, Guam, Maldives & Thailand.
Offer ends on 23th November. Discount applies to flexible and bed and breakfast rate.
See also our Hilton hotel reviews.
Expedia campaign page opens on November 23th at 9 am (Pacific Time) for a $100 off coupon on select flights, extra 75% off coupon on select hotels and more.
Shangri-La Black Friday special deal – book your next summer holiday and get 50% cash back on Dining and Spa.
Book anytime from November 23rd – November 30th for stays between May 1st – September 30th, 2019 at participating hotels and resorts.
This Cyber Week, get 25% off when you book between November 23rd – November 30th 2018 and stay between November 26th 2018 – March 31st 2019.
Plus – Book a Bonus Points Package and earn 50% more bonus points when you book between November 23th – November 30th for stays between November 26th – December 31st.
See also our Intercontinental hotel reviews.
Black Friday offer: 40% off of Best Flexible Rate at participating hotels worldwide. Accor Plus members can get an additional 10% off for stays in Asia-Pacific region.
The offer is valid for stays January 1st – February 24th, 2019 – Book before November 26th 2018.
Please note that all Black Friday flight offers on Alwaysflybusiness.com are accurate at the time of publication. Prices and availability change every day, and the deal might exist only for a short period. | 2019-04-23T22:19:55Z | https://www.alwaysflybusiness.com/black-friday-2018-flight-and-hotel-deals-british-airways-qatar-airways-finnair-and-more/ |
We’d love to hear from you so please fill out the form below and we will definitely get back to you in a day or so. Promise. Absolutely anything you need to ask or just if you want to say hi. Don’t be shy. | 2019-04-22T20:01:45Z | https://jwalkingin.com/home/contact-us/ |
ID:18020101 / To show the mighty entrance of the glacier cave, I had to climb deeper into the glacier through some ice blocks that were obstructing the passage. What a stunning view!
ID:18020538 / With its 1800m, the Summit of Mt. Rigi breaks through a cloud inversion layer. During this winter sunset there was a beautiful pastel color palette to the image. | 2019-04-25T23:50:17Z | https://www.jhribarfoto.com/Photos/Countries/Switzerland/ |
Legendary Food, Legendary Service, and Legendary Fun! At Texas Roadhouse, we take pride in everything we do from hand-cut steaks and fall-off-the-bone ribs, to some pretty sweet margaritas. And we do it all with one goal to give your family a place to go for great food and good times at a fantastic price. | 2019-04-21T20:23:46Z | https://www.naturalnorthflorida.com/places-to-eat/texas-roadhouse/ |
(30% Share). A lovely two bedroom flat situated on the fourth floor of a modern development with lift, boasting bright and contemporary interiors throughout and a charming private balcony.
Full value £520,000. Rent per month: £485.77. SC per month: £89.85. Minimum household income: £51,053. Minimum savings: £8,800. Approx monthly mortgage payments: £591.32. Total Monthly Payments: £1,166.34. | 2019-04-21T10:49:58Z | https://www.foxtons.co.uk/properties-for-sale/e8/chpk4640281 |
Carlos Roberto Baute Jiménez (born March 8, 1974; Caracas, Venezuela), best known as Carlos Baute, is a Venezuelan singer and television host. His music is mostly in the Latin pop genre, with some ballads and Bachata. He is the son of Alfonso Baute and Clara Jiménez and he is of Spanish (his father is from Tenerife and his maternal great-grandparents are from Galicia), Cuban (his maternal grandmother) and Venezuelan descent. At age 13, he started a band called "Los Chamos" and released an album entitled "Con un poco de Amor".
Most popular single tracks by Carlos Baute.
Most popular albums released by Carlos Baute.
Find other artists who are similar to Carlos Baute. | 2019-04-22T02:59:24Z | https://www.hotmusiccharts.com/artist/carlos-baute |
Anti-Allergen Deodorizer is designed for safe use around individuals who suffer from allergies, asthma, or chemical sensitivities. Anti-Allergen Deodorizer is an oxidizing odor counteractant that is perfume free. Uses oxidation to converts bad odors into odor-free compounds. It is for use on all types of odors.
Anti-Allergen Deodorizer is formulated for homeowners who are sensitive to perfumes and pesticides.
Environmentally safe and does not contain pesticides, perfumes, harmful solvents, or other hazardous ingredients.
Test for colorfastness or color changes on textiles in an inconspicuous area before using.
Mix 1 part Anti-Allergen Deodorizer with 10 parts water (12 oz. per gallon). Mix well and apply to affected areas with a pump-up or electric sprayer.
Locate urine contaminated areas with a black light or moisture detector. Spray areas until saturated. Thoroughly clean carpets.
For best results, use in an in-line pressure sprayer undiluted and rake in product. Allow 10-20 minutes dwell time. | 2019-04-23T04:07:45Z | https://masterblend.net/en/clean/responsiblecare/anti-allergen-deodorizer-2 |
Homestead Designs provides gorgeous handcrafted structures that are made to endure by Amish craftsmen at a modest price. Take a stroll through our lot and see first-hand why we crush the competition.
Our no pressure, competent staff will be happy to explain all the available options and address any concerns. Exceptional attention to detail and second to none customer service since 2001 ensures that your building satisfies your needs and our LOCAL DELIVERY adds even more value.
We work hard to make sure your new shed, garage, gazebo, or custom structure is right for you, but we don't stop there. We also offer a FREE SITE CHECK to check structure location, foundation, and delivery access. This virtually guarantees your building arrives onsite in Machias, Ny safely and conveniently.
Providing Sheds, Gazebos, and Pergolas to Machias, Ny and the surrounding areas. | 2019-04-23T03:59:36Z | https://homesteaddesigns.com/sales-installation-delivery-in/machias_ny_979180-20/ |
Royal Enfield has just released another variant of their Bullet, the Royal Enfield Woodsman in the style of retro trail bikes. Just like Triumph did with the Triumph Scrambler.
The 499cc single cylinder engine has a top speed of 70mph and produces a modest 27bhp.
MCN's road test editor Phil West rode the motorcycle and said: "In short, the Woodsman's a treat. For me, it's ergonomic mix of pegs and bars, fruity pipe and overall style hit the mark more than any other Royal Enfield."
You can see the full specifications and more about Phil's outing on the Royal Enfield Woodsman in this week's MCN, out May 14, 2008. | 2019-04-21T12:15:15Z | https://www.motorcyclenews.com/news/new-bikes/2008/may/may1308royalenfieldwoodsmanpicturegallery-/ |
When they was this, here in the regulation were based with system. Thus, because the absence of X resulted in the loss of A, we are led to conclude that the former must be necessary for the latter. Drawings by Sato et al. Hence the distribution of some gene expressions is available. In the next section, we will discuss the validity of the logic presented in this scenario, by carrying out numerical simulations of the stochastic model based on the above argument. For a cell to grow recursively, a set of chemicals has to be synthesized for the next generation.
Now, let us suppose that we have been sent into outer space with the mission of determining the presence or absence of life. The left graph displays that with regards to Ny , with integrating out the values of Nx , while the right graph displays that with regards to Nx , by integrating out the value of Nx. Furthermore, it is often the case that the type of diversity discussed in Sect. The connection strength among elements in each group is not necessarily strong. At this time, such regeneration is known to exist only for certain local neural circuits, but it is also known that when certain areas of the brain are damaged, other areas can take over the role once played by the damaged area.
The number of molecules in question starts to decrease only after it goes above the value for which the two mechanisms are balanced, and this decrease turns to the increase after it passes the balance point. In such biological system, constituting units have their own internal dynamics, and they are interacting. In general, the behavior of a living creature is not uniquely determined by its genes and the environmental conditions to which it is subject. From the threshold noise σthr , it may be possible to estimate the minimal number of molecules in a cell, required to have a robust development process. When the total number of molecules exceeds a given threshold, the cell divides into two, with each daughter cell inheriting half of the molecules of the mother, chosen randomly. Rather, we must carry out research that attempts to understand the overall behavior resulting from the many processes occurring inside organisms.
Indeed, even y x y with our stochastic simulation, this number distribution is approached as N is increased. During this reaction two phosphate groups are split off. Such phenomena have been investigated in relation to the reversibility of neural networks. Among newts, there exists a diploid i. However, in the growth process, the number of cell divisions is half that of a normal newt, and as a result, the sizes of the normal and mutant forms are essentially the same. However, in fact such oneto-one relationships among molecules and functions are exceptional in living systems. Exercises, solvable with pen-and-paper calculations, appear throughout the text to encourage interaction with the mathematical techniques.
Often the distances between protein molecules and the size of the molecules are of the same order Goodsell, 1998. Systems biology, ultimately, creates the potential for entirely new kinds of exploration, and drives constant innovation in biology-based technology and computation. Schematic illustration of their self-replicating membrane system is shown in Fig. In this sense, construction is for the analysis or understanding what life is Kaneko, 2003b. Ecologists would most likely consider interaction to be the relation of individuals in an ecological system such as prey—predator relationship. Of course, there are situations in which such a premise is valid and the description that it leads to is in fact useful.
In a cell, among many chemicals, only some chemicals e. Of course, the growth rate also depends on Nx0 , but this dependence is much weaker see Fig. Subsequently, the total number of molecules in each daughter cell increases from N to 2N , at which point these divide. In addition, the types of correspondences that exist in any given case depend on the environmental conditions, and therefore change in time. Although it often appears that the cause of a transition undergone by a cell lies in the genes, the information that we can obtain experimentally is only that regarding correlations.
Author by : Robert A. The third term describes the transport of chemicals through the membrane, where ni is a constant, representing the number of the i-th chemical species in the environment and V denotes the volume of the environment in units of the initial cell size. Each cell in a cell population of apparently identical cells is a distinct individual. What type of system is life? Plotted are the temporal averages, taken from the latest division to a time step 2000. In other words, if the noise becomes too large, a developmental process with the increase in the cell number does no longer occur. By checking the self-consistency of the states, we can solve the behavior of each state.
Each species has active and inactive molecule types, with only the active types of one species catalyzing the replication of the other species for the replication. This problem is discussed in Chap. Next, we show that the molecule species Y the minority species becomes dominant in determining the growth speed of the protocell system. It is thus clear that what we seek is to model organisms as systems in which dynamic and condition-dependent functions appear by virtue of the interaction among constituent elements. The properties of each constituent comes to be determined through its relation to the whole 28 1 How Should Living Systems Be Studied? Of course, if we consider the response to changes in external conditions over long time scales, we encounter the problem of evolution. The synthesis of such a cell structure is an important problem Bachman et al.
It takes the following viewpoint to attain the goal. However, such an error correction program too would have to be based on chemical reactions, and, here again, the number of molecules involved in these reactions could not be large. To reiterate, what we propose here is to construct a system according to the conditions we have chosen, and with such a system, to recreate the fundamental properties and functions of living systems. With this goal, there is no reason to focus on the organisms that happen to exist on Earth at this time. In this experiment, one has to supply some enzyme, from outside, and in this sense it is not an autonomous replication system.
What is the origin of this complexity? Here, we are reminded of the following story about the Chinese philosopher Zhuangzi 2—3 century B. The Virtual Liver network takes on the challenge. For example, if there exists some property of an organism that bestows it with a particular faculty, even if this faculty exists at some very low level initially, through evolution, it can come to attain some higher level of functioning. Then, using this computer, we could not expect a program that calls, say, on the order of 10 operations to give a correct result. In the next section, we consider the representation of irreversibility as a loss of plasticity. These examples demonstrate that such correspondences are ambiguous. | 2019-04-24T16:13:14Z | http://himaswitch.com/life-an-introduction-to-complex-systems-biology-understanding-complex-systems.html |
When, where and with whom do you experience Anxiety Symptoms* or Panic Attacks?
What type of physical activity is helpful to decrease your anxiety symptoms? What have you tried? What can you try in the future?
What can you do to minimize distractions in your environment (s); be more organized? simplify daily routines?
What can you do to improve the interpersonal relationships you have with others? How are your boundaries? Are you always saying Yes? or No?
What changes can you make to food and substance choices that will help to decrease symptoms of anxiety? Caffeine intake? Alcohol? Nicotine? Sugar?
How can you ensure you have people in your life to share your concerns?
How are you incorporating time for spiritual contemplation?
*Symptoms of anxiety may include; shortness of breath, heart pounding, sweating, shaking, lightheadedness, feeling of unreality, fear- wanting to get away etc. | 2019-04-24T14:10:17Z | https://barblarkincounselling.com/2012/10/01/questions-to-ask-yourself-if-you-are-experiencing-anxiety-symptoms-or-panic-attacks/ |
Fireworks are legal in the Town of Kittery.
There is no Town ordinance regarding the use of fireworks. In the absence of an ordinance, The Town of Kittery follows State law regarding their usage.
A person may use consumer fireworks only on that person's property or on the property of a person who has consented to the use of consumer fireworks on that property.
A person under the age of 21 may not purchase, use or possess consumer fireworks. | 2019-04-25T03:45:42Z | http://www.kitterypolice.com/fireworks.html |
If you need to do your homework quickly and inexpensively you can do it with Assignment Expert. We can easily answer your questions: "Who will do my homework now?" or "Who can do my homework online? “. Our service can easily solve your problems. Our experts fulfill the work of any complexity without difficulties. | 2019-04-20T08:41:19Z | https://pujckabwvhwcm.webgarden.cz/rubriky/answer-my-homework |
4/27, 8AM-2PM (no early birds please); 1801 Ironwood, West Richland (follow signs on Paradise Drive). Adult clothing (including nursing scrubs); Patio furn; Household items; More!
MOVING YARD sale! 2797 Chicory Dr, West Richland (off Holly). Fri, 4/26, 9am-1pm, Sat, 4/27, 9am-2pm. Black bear rug; Electric tools; Knick knacks; Household furniture; King bed with all bedding; Grey couch from Macy's; Patio table set; 3 piece outdoor furniture set; Dining room table set; Mens tools; Bookshelves; Beautiful live potted plants; Oriental furnishings; Small childrens clothes; Gold plated silverware set. Future sale will include unique collectibles/ antiques! Stay tuned for our next ad!
Big garage sale in North Richland, like each spring for the past many years! Huge variety of clean items! Drive to 1860 Alder Ave, Richland (at the corner with Bismark St). Sat, April 27th, 7:30am-12:30pm.
RICHLAND Lutheran Church Annual Yard Sale, Fri & Sat, April 26th- 27th, from 8am-2pm. 901 Van Giesen St. There will be a large variety of donated items for sale.
Never agree to ship your item and give someone a refund for a cashier's check money order they send you. It's a scam!
2810 Leopold Lane, Richland, May 4th (Sat), 8am-1pm. Several furniture items; All types of decor, including holidays items; Outdoor tools; Lots of Seahawks items.
CHURCH RUMMAGE sale: Fri, 8am-1pm, Sat, 8am-12pm. Meadow Springs Presbyterian Church, 325 Silver Meadow Dr, Richland. (From Keene, turn south onto Silverwood Dr, then immediate right. Follow signs to Fellowship Hall.) Household items; Plants; Baked goods; Clothing; Toys; Tools; Sporting goods; More! Come find your treasure!
Five friends yard sale at 1037 Wright Ave, Richland. Kitchen items; Baskets; Roll top desk; Toaster oven; Home decor; Picture frames. Many other items. May 4th, Sat only! 9am-3pm.
Nursery grown bedding plants at value prices. Yokes Parking lot, 1401 Bombing Range Rd, West Richland. 4/26, 8am-7pm & 4/27, 8am-3pm. | 2019-04-26T02:53:57Z | http://www.giantnickel.com/yard-sale-richland |
The Monan’s Rill community owns approximately 440 acres of land. We are a partnership, and as such none of us holds individual title to the land or the buildings upon it. However, each family or individual member does live in a private home.
Upon becoming a Member, an individual contributes an initial monetary investment, and thereafter pays a monthly fee. The funds are used for capital improvements, general maintenance and community business. | 2019-04-24T20:10:30Z | http://www.monansrill.org/?page_id=295 |
The Cowboys' coming to life party at Houston gave Fox4 a healthy dose of mega-ratings Sunday.
The noon game win, by a score of 27-13, averaged 1,322,809 D-FW viewers while CBS' competing Giants-Titans game had 69,257. Um, that's a blowout.
The NFL then scored again with CBS' Colts-Broncos game (nicely spiced with bonus coverage of San Diego-Seattle). That combo ran well into 60 Minutes' usual 6 p.m. starting time and averaged 422,468 viewers. NBC's Sunday Night Football matchup between the Jets and Dolphins controlled prime-time with 484,799 viewers.
ABC's season premiere of Desperate Housewives led all non-sports programming Sunday with 360,136 viewers. But Fox's season-opening one-hour Family Guy handily beat DH head to head among advertiser-coveted 18-to-49-year-olds.
On Saturday, the Texas Rangers officially clinched the American League West, their first division title in 11 seasons, with a 4-3 win at Oakland. The magic moment was at 6:24 p.m., with 304,731 viewers watching Fox's telecast during that 15-minute increment (6:15 to 6:30 p.m.).
Two competing college football games -- UCLA's rout of Texas and Alabama's hang-on win at Arkansas -- respectively averaged 256,251 and 214,697 viewers on ABC and CBS. But each of those games had higher peak audiences than the Rangers did. Overall, the North Texas 9 ran third against Texas-UCLA and Bama-Hogs, but did trounce NBC's Notre Dame-Stanford game (20,777 viewers).
Let's swing over to Friday, where ESPN's TCU-SMU game on the Ponys' home field averaged 221,622 viewers overall. Still, CBS' 9 p.m. premiere of Tom Selleck's Blue Bloods had the biggest audience of the entire day with 270,102 total viewers while tying the first hour of TXA21's Rangers-A's game for second with 18-to-49-year-olds behind No. 1 TCU-SMU. NBC's new Outlaw, with Jimmy Smits at the throttle, ran fourth at 9 p.m. in total viewers (117,737) and fifth with 18-to-49-year-olds.
Fox's Friday 8 p.m. launch of The Good Guys, which had abysmal ratings for a summertime run on a different night, drew 90,034 total viewers in beating only ABC's The Whole Truth repeat among the Big Four broadcast networks. Urp, Good Guys also was outdrawn by WWE Smackdown! on MY27, as was the new-night-and-time premiere of CBS' CSI: NY. The 8 to 9 p.m. portion of TCU-SMU also beat both Good Guys and CSI: NY.
In the 18-to-49-year-old barometer, Good Guys barely came up for air with 6,581 viewers compared to league-leading TCU-SMU's 105,299 from 8 to 9 p.m. That placed it seventh in the broadcast network rankings alone, with Smackdown! leading the way followed by NBC's Dateline, The CW's Supernatural, Whole Truth, CSI: NY and the Rangers pre-game show. Although its D-FW numbers were sickly, CSI: NY did much better nationally, winning its time slot in both ratings measurements.
But Good Guy's numbers were just as dismal country-wide. So sorry to say, the bloom is turning to gloom on the local production front. Good Guys is on fumes at best, and Fox's critically acclaimed Lone Star, also filmed in North Texas, might well have its final telecast Monday night after shockingly low ratings for the previous Monday's premiere episode. That leaves the third North Texas entry, NBC's Chase, still standing after a decent but not great showing in its Monday launch against CBS' Hawaii Five-0.
On to Friday's local news derby results, where CBS11 won at 10 p.m. in total viewers but slid all the way to fourth among 25-to-54-year-olds (the preferred advertiser target audience for news programming) despite the hefty lead-in advantage from Blue Bloods. WFAA8 took the gold in that key demographic.
Fox4 swept the 6 a.m. competitions against arch rival NBC5 while CBS11 ran the table at 6 p.m.
NOTE TO READERS: Nielsen Media Research has issued its annual adjustments to D-FW population estimates, with across-the-board increases in the three major food groups. These new estimates are reflected in today's "Snapshot."
In total D-FW viewers, there's a 1,394 increase per rating point.
Among 25-to-54-year-olds, it's an increase of 377.
And among 18-to-49-year-olds, there's an increase of 290 viewers per rating point. | 2019-04-20T16:17:03Z | http://unclebarky.com/dfw_files/4c7b9586e46adea56ff876a5bebc6d02-1735.html |
Douglas Dunn is a poet, critic, and short story writer, much of whose fiction has appeared in The New Yorker. His many notable books—published by Faber—include the influential collections Terry Street (1969), Barbarians (1979), and St Kilda’s Parliament (1981); Elegies (1985), which was Whitbread Book of the Year; and New Selected Poems 1964-2000 (2002). He taught at the University of St. Andrews from 1991 to 2008. He was made an OBE in 2003 and awarded the Queen’s Gold Medal for Poetry for 2013. | 2019-04-23T18:06:36Z | https://www.pshares.org/authors/douglas-dunn |
Ahhh, Miss Sporty. What a throwback. Anyone else remember Miss Sporty makeup? It brings me right back to my teenage years when my makeup ‘collection’ was full to the brim of Miss Sporty and similar brands.
Although I haven’t used many (read: most) of their products in a number of years, one item I do use and love is their individual eyeshadow in the shade ‘112 Amber’. It is a gorgeous shimmering warm bronze that packs a punch in the pigment department, especially for something that costs so little.
It reminds me a lot of ColourPop Cosmetics ‘Nillionaire’, but it is slightly darker, not as wet looking and without the glitter. It’s slightly darker and warmer than Nillionaire, but close in colour.
I’ve used this a number of times since I picked it up and so far, I’m quite enjoying it (and the nostalgia that comes with it ). I think this was 70c in Dealz and when I saw it, I couldn’t resist it.
It is quite a ‘soft’ powder, it feels delicate and almost fragile. There is quite a bit of fallout from it, but nothing that a quick sweep of a brush won’t sort out. It doesn’t ‘streak’ when brushing away and when blending on the eye, it doesn’t blend away to nothing either.
For a product that was so cheap it’s actually not the worst quality. I mean, it’s not high-end quality by any means, it’s not going to be, but it’s pretty decent.
Have you ever tried Miss Sporty makeup? What cosmetic brands did you use as a teen? I’d love to know. | 2019-04-21T00:33:13Z | https://beauty-brat.com/2019/04/miss-sporty-112amber-eyeshadow/ |
Some amazing stories of redemption were told this week at Brookside! Check out our baptism service and Orphan Sunday here!
Michael Brown makes some big statements and backs them up with the Scripture to prove it in his message, “God As My Friend”.
Ever wondered what your Spiritual Gift is? Steve Rieske gives the lowdown on spiritual gifts, being a gifting-led church, and more in this week's sermon.
Happy Mother's Day! Amy Seiffert speaks on motherhood, trusting God, and the blessing of children being like arrows in our hands in yesterday's sermon. She also hands to mic to 4 different moms with short stories to share! | 2019-04-24T14:40:19Z | https://www.brooksidechurch.net/sermonsblog?category=Brookside+Church |
Engagement 3 hours coverage 50 jpg file (high res) Lifestyle photography is about the little details Each couple is different, their story is unique, and so my lifestyle photo shoot approach helps reflects that. My goal is to capture real moments: The moments in between all of the hustle and bustle of the wedding. Or the laughter over a shared joke. And the quiet moments of contemplation before becoming united with your partner.
Customized services only Standard prices: Full: 8 hours with 2 photographers; About 800 post-produced pictures DVD and Dropbox or flash drive delivery; About 50 Drone pictures; Drone video; Book; Payment by Paypal, bank or cash; Ground video to be quoted separately.
Outdoor photo session in Cinque Terre, Portovenere, Lerici or any other nearby location. Duration around 1 and half hour (may vary if requested). Pictures delivered digitally. Price can change if duration of shooting session or location changes. I prefer to talk with people (by message/skype/email/voice) to organize the photo session and find the price that best fits the needings.
Customized services only Standard prices: Short: 4 hours with 2 photographers; About 400 post-produced pictures DVD and Dropbox or flash drive delivery; About 20 Drone pictures Payment by Paypal, bank or cash. Book, aerial and ground video to be quoted separately. | 2019-04-25T02:09:24Z | https://ibride.com/packages/liguria--italy/photography/ |
Hi Kylie, happy to support you in your support of a great cause and know that the funds will actually go to where they're needed. All the best with your walking!
Great to see you supporting a great cause - please don't come home with the wooden spoon!
Good luck from the BD BP Team!
All the best for your long walk Kylie - awesome cause. | 2019-04-26T15:56:42Z | https://donate.waysidechapel.org.au/fundraisers/kyliebullock/long-walk-home |
In true Filipino tradition, this post is fashionably late. Although Filipino American History Month is over, perhaps the timing of this post will help the celebration last longer. To kick of FAHM, San Francisco's Asian Art Museum hosted "Farms to Tables: Filipino Americans Then and Now". The event, centered around food, had an excellent balance of history, contemporary issues, and cultural presentations.
It showcased the essental role of Filipino Americans in America's farm labor movement. This coincides with Governor Brown's signing of Assemblymember Bonta's Filipino American Farm Worker Bill, AB 123. Although Filipinos, like Larry Itliong and Philip Vera Cruz, were instrumental in the movement's success, they are often overlooked in the history books. This bill ensures the Filipno American effort is rightfully included in California curriculum.
Eating healthy was also a big theme. We Filipinos love our lechon, crispy pata, and chicharon but it's important to remember we have healthier options. The American Heart Association put together a cooking lesson and handed out healthy recipes. I will have to try this soon!
I also got a chance to meet PJ Quesada from Ramar Foods and The Filipino Food Movement. Ramar Foods is a family business that manufactures and distributes a lot of classic products. Every Filipino American has to know and love Magnolia Ice Cream! According to PJ, Whole Foods carries their ready-made dishes like chicken sisig, lumpia, empanadas and more.
Their non-profit, The Filipino Food Movement, works to promote Filipino Cuisine. It's true that outside of our communities, Filipino Food is still very foreign and unknown. A lot of people have no idea how delicious and diverse our food can be. PJ also recommended I check out Memories of Philippine Kitchens. I recently picked it up. Stay tuned for a in-depth post.
Lastly there were cultural performances and workshops. I got my last name written in baybayin, the pre-Spanish Filipino script. Above is an image of Jay Loyola of Bayanihan Philippine National Folk Dance Company. The singer, Tracy Sarmiento, was amazing as she sang in both Tagalog and English.
Because food was a big theme, there was a large altar with filled with fruits in vegetables commonly found in Filipino dishes. There was okra, eggplant, squash, watermelon, tomatoes, and much more. Guests were invited to bring some home. I was actually the first person to pick from the altar. As soon as I picked up that eggplant, it was over. All these lolas [tagalog for grandma] busted out shopping bags and cleaned house! They looked like they just came from the palengke [public market].
The entire event was great and inspired me to continue learning more about Filipino culture. It's events like this that really get me excited and motivated. I'm very glad I was able to make it out. | 2019-04-22T23:02:36Z | http://www.ljshotyou.com/2013/11/farms-to-tables-filipino-americans-then.html |
Gary is licensed to practice law in both Indiana and Kentucky. He concentrates his practice in estate planning, estate and trust administration, estate and trust litigation, guardianships, elder law and special needs planning. Gary earned his J.D. from the University of Louisville, Louis D. Brandeis School of Law and formerly practiced law at Bingham Greenebaum Doll and Wyatt, Tarrant & Combs.
Gary currently lives in Floyds Knobs, Indiana where he grew up and attended Floyd Central High School. He is married to Angie Banet and they have two children. Angie is pursuing her doctorate degree in nursing practice and currently serves as the director of care management at Norton Women’s and Children Hospital.
Gary a Business First’s Forty Under Forty recipient, named one of 20 under 40 Best and Brightest by the Southern Indiana Business Source and recognized by Super Lawyers as an Indiana Rising Star Attorney in 2014, 2015, 2016, and 2017. In addition to practicing law, Gary is active in the community and serves on several non-profit boards such as the Louisville Waterfront Botanical Gardens and the One Southern Indiana Foundation.
Named one of “20 Under 40 Best and Brightest” business professionals by Southern Indiana Business Source.
Recognized by Super Lawyers as an Indiana Rising Star 2014-2016, one of only two lawyers in Southeast Indiana listed in the publication under the Estate Planning & Probate Category.
“So, is your ‘Plan’ to live forever? – Top 5 reasons for an entrepreneur to have a buy-sell agreement.” Southern Indiana Business Source, January 2014. | 2019-04-21T10:26:02Z | https://www.newalbanylaw.com/attorney-gary-banet/ |
“I’m not a politician; I’ve never considered running for Congress until recently,” Janz told The Bee on Monday. “Most of the stuff in local and national media has pushed me to get involved,” he added, referring to a House Ethics Committee investigation into whether Nunes – chairman of the House Intelligence Committee – mishandled classified information related to the House Intelligence Committee’s Russia probe.
It’s my desire to take what I’m doing now as a prosecutor and take that to the voters of the 22nd District.
Janz, a Democrat, grew up in Visalia, graduating from Redwood High School. He received a bachelor of arts degree in economics in 2006 and a master’s degree in public administration in 2009, both from California State University, Stanislaus. Janz earned his law degree from Southwestern Law School in Los Angeles in 2012.
After graduating law school, he clerked for a Clark County district court judge in Las Vegas. Janz joined the Fresno County District Attorney’s Office in 2014. He estimates that he’s handled about two dozen trials in the past three years, most of them involving violent offenders.
Nunes has been a formidable candidate since he was first elected in 2002 in what was then the 21st Congressional District, never receiving less than 62 percent of the vote. He ran unopposed in 2010. Reapportionment redrew the districts after the 2010 census, putting Nunes in the 22nd District since 2012. Nunes garnered nearly 68 percent of the vote in 2016, when he handily defeated Democrat Louie J. Campos.
Republicans hold a significant voter registration advantage in the district – 42.8 percent of voters identify themselves as Republicans, compared to 32.8 percent Democrats. But a significant proportion of the voters – more than 19 percent – listed no party preference on their registration as of February.
Protesters voices filled the air with discontent regarding Rep. Devin Nunes, during his appearance at TorNino’s Banquet for a meeting on water. Nunes did not face the protesters, slipping in a rear entrance of the banquet hall. | 2019-04-19T08:33:10Z | https://www.fresnobee.com/news/politics-government/politics-columns-blogs/political-notebook/article146512949.html |
With Easter less than 4 weeks away it� s definitely time to start planning your summer sailing!
Right now, all you need to do is get a date in the diary, and then you can sit back and relax and dream of a balmy sailing day on the Solent. Your guests will appreciate your generous invitation and don� t forget you will have their full attention for the day when we set sail.
Will you enjoy one of our on board hospitality menus this year or step ashore to one of the Islands many welcoming hostelries? Will it be Cowes or Yarmouth, or will you just wait and see where the wind and tide take us! | 2019-04-23T08:49:29Z | http://valhallayachting.com/news_items/index/21 |
“La Tavola Lunga” – the long table – has been an integral part of the De Bortoli family heritage ever since Vittorio put down roots in the Riverina early last century.
Vittorio was a man who loved to cook and to eat and he provided lunch every day for his family and farmworkers around a long table. La Tavola Lunga was a place to discuss business and life and, for the often homesick Italian workers, it was also a warm, hospitable piece of home.
The tradition continues to this day, from Emeri’s staff lunches at her house in Bilbul every Tuesday to Leanne and Steve feeding friends and family on the back terrace of their home in the Yarra Valley. | 2019-04-20T17:23:00Z | https://www.debortoli.com.au/about-us/our-heritage/la-tavola-lunga/ |
I still cannot it has been 3.5 months since I ventured back into working. It feels like weeks, not months. I found going back this time very different than after Avery. After Avery, it was a world of unknowns, a scary one at that but as the days passed we fell into a new groove and life that we all enjoyed a lot. After Chloe I knew what to expect going back to work and it made the whole transition so much easier. But with working full time, being a Mom, a Wife, this blog, running & training for races plus everything else that falls my way there has to be some sacrifices too.
By nature, I am a type A person so letting things “fall to the wayside” is much easier said that done. Those dishes in the sink? Yeah, they do not need to be done, but for my sanity, they actually do and probably right now so the whole letting those little things go in order for me to still have time for my family is hard some days. But with a little work, a whole lot of planning and an awesome side-kick it is all very possible.
So what have I learned in this past few months?
1 – I cannot plan enough. True story. Meal planning, workouts, my lunch hours, grocery shopping…and more. I find planning these things and times to do these things helps us get it all done.
2- I have an awesome husband. I knew this already but without Chad I could not do what I do.
4 – Two kids is not twice the work. More like 100x – HA. But I would not change it for the world.
5- Flexibility is key – all the time. Kids get sick, they nap at the wrong hour, they get cranky, life gets busy and so on. I am such a planner that sometimes these last minute changes can really get to me but I am learning to roll with it more as life rarely goes as planned.
7 – I am tired… a lot. But that is life right now so I do not dwell on it.
8 – It really does take a village. From my job being flexible, our great dayhome, family and friends. I could not do it without everyone.
This entry was posted in Mama Talk, Mom Life, Uncategorized, working mom on 26 April, 2017 by Lindsey Knudson. | 2019-04-18T20:48:02Z | http://arunningtale.com/2017/04/26/ |
SP Winds Run Amsterdam 2017 | JustRunLah!
The objective of the run is to COLLECT FUND for the SP Winds to participate in World Music Competition 2017 in Netherland. They need a considerable amount of money to be able to take part in the event. I.e. payment to organizer, air fares and coaches, accommodation, food etc.
We look forward to kind and benevolent companies, corporations and individuals taking part in this run for the girls. This is the least that we all can do for them as they have been practicing with their instruments really hard. See you all there. Thank you. | 2019-04-23T09:54:46Z | https://www.justrunlah.com/race/sp-winds-run-amsterdam-2017/ |
We have reached the end of the year of 2017, Christmas parties will soon be in full swing. Did you find comfortable and stylish clothes to wear? If not, Zaful is now promoting Christmas sale (https://www.zaful.com/m-promotion-active-christmas.html?lkid=12282757) with various adorable products at cutthroat price. Below is some Christmas party fashion items in Zaful (https://www.zaful.com/?lkid=12282757) which you should have. | 2019-04-23T10:39:53Z | https://pricejednevestice.wordpress.com/2017/12/15/spend-a-little-time-with-zaful-before-2017-ends/ |
I grew up in Mandeville, Louisiana (part of the New Orleans metropolitan area). I attended The University of Alabama and received a Bachelor of Science with a major in Psychology and a minor in Biology. I earned my Doctor of Dental Surgery degree from Louisiana State University School of Dentistry in New Orleans. I am a member of the Missouri Dental Association, the American Dental Association and the Academy of General Dentistry.
I enjoy spending time with my husband, Taylor, and my dog, Stella, as well as hanging out with family and friends. In my spare time, I like to cook, travel, exercise, spend time outdoors, and cheer for the New Orleans Saints and The University of Alabama Crimson Tide!
I am excited to join the Cherry Hill dental team, meet new patients, and improve smiles in the Columbia area!
Roll Tide and Who Dat!? | 2019-04-24T20:17:23Z | https://www.cherryhilldentalonline.com/meet-dr-gabrielle-colon |
Costa del Caribe Realty, Inc, your Gateway to the Caribbean side of Puerto Rico, Palmas del Mar, Humacao for over 26 years making the dream come to life. "You've got to be here, Puerto Rico, What a Place!
Special of the Month > Daily New Listings for Home Sales and Long Term Rentals in all areas in Palmas del Mar,Humacao- The Caribbean Side of Puerto Rico.Great deals are happening as we speak....Special of the Month> Crescent Cove >> Three bedrooms & 3.5 baths furnished & equipped, Facing Caribbean Sea & swimming Pool>> $355,000. Wonderful Ocean Front Penthouse in Marbella Club> Now $599,000 Exciting 3 bedroom Custom Home on a Cliff overlooking Caribbean in Harbourlights Extension at Palmas, Now $535,000. Terrific 2 Bedrooms Garden in Maralago with Breakfast nook... Now $285.000. See all our listings in www.palmasdreams.com. See for yourselves in our musical Virtual Tours. Now is the time to get in on a good thing. Costa del Caribe Realty, Inc. at Palmas will show you the way.
***Click on the Link for "Virtual tours" on all our listings for Sales & Long Term Rentals in Puerto Rico. | 2019-04-23T06:26:44Z | http://www.palmastropicaldreams.com/feature-listings.html |
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It might feel like winter is never going to end, but spring will be here before you know it.
If you're planning to list your Tri-Cities home for sale on the spring real estate market, now is the time to prepare. Getting your home ready now will minimize your stress later and allow you to get a jump on your listing before other spring home sales come on the market.
Not sure where to start? No problem! Our REALTORS® are here to share their list of the top seven things you can do now to help make your house stand out this spring.
Take a careful look at each room in your home and create a list of small improvements you can do yourself. Keep an eye out for things like missing trim, chipped paint, broken light fixtures, smudges on the floor, and carpet stains.
Once you've completed your list, get started! Taking on small projects in your free time is far better than trying to tackle them all at once right before your listing.
If your house is a mess when prospective buyers some to check it out, it might cause you to miss out on a sale. While you're cooped up inside, use it as an opportunity to thin out your belongings.
It's important that prospective buyers can visualize themselves living in the home, so go ahead and pack up things like framed photos and personal items, and put excess furniture in storage.
Assess your home honestly to determine if you can make some changes to brighten it up. Is the paint too dark? Does the wallpaper need to be replaced? Are the drapes heavy and outdated?
Consider adding fresh coats of light, neutral-colored paint, replacing dirty carpets, polishing wood floors, and swapping out your furniture for lighter, more modern pieces.
Now is a great time to take care of any maintenance projects you may have been putting off. This includes tasks like changing out your air filters, maintaining your septic tank, fixing leaky faucets, flushing out your water heater, and oiling your garage door hinges.
The kitchen is one of the most important considerations for potential home buyers, and upgrades typically take time. This means that right now is the best time to do an assessment and decide if you need to make any changes.
Painting cabinet doors and replacing countertops are some minor upgrades that can make a big difference. If you're not sure whether an upgrade is worth the investment, consult with a realtor who can give you honest feedback.
As soon as the snow melts, you'll want to jump on your outdoor projects. Start by raking up fallen leaves and branches, then trim and prune your trees and bushes.
Aerate your lawn, so it grows in full and lush. Add seed to any bare spots. Buy some plants and fertilize them, so they look full and healthy when prospective buyers arrive.
If you wait until the springtime to start looking for a real estate agent, both you and your agent will feel rushed to make important decisions. Starting now will give you a chance to conduct interviews and make sure you find an agent with whom you're comfortable working.
Many buyers planning to move in the spring start viewing homes early in the spring. Our REALTORS® can help you put your home at the forefront of Central Virginia's real estate market. Contact our Tri-Cities office to make it happen.
© 2019 Napier Old Colony Realtors Inc, dba Napier Realtors ERA. All rights reserved.
ERA® and the ERA logo are registered service marks owned by ERA Franchise Systems LLC. Napier Realtors ERA fully supports the principles of the Fair Housing Act and the Equal Opportunity Act. Each franchise is independently owned and operated. Any services or products provided by independently owned and operated franchises are not provided by, affiliated with or related to ERA Franchise Systems LLC nor any of its affiliated companies.
Agency License Information: A licensed real estate firm in the state of Virginia. | 2019-04-22T06:30:47Z | http://www.thesinnettgroup.com/blog/2019/02/19/7-tips-to-get-your-tri-cities-home-ready-to-sell-this-spring-2 |
This site may be hacked or fraudulent. Giving it passwords or personal information could put you at risk for identity theft or financial fraud.
I can simply go to dropbox.com its working fine, but any photo links with dropbox marked as phishing page.
Our fraud reports are maintained by third-party vendors.
I wanted to exclude this domain, i checked settings but i couldnt find anything to exclude this domain from alerting as phishing.
Wow, that's strange. I think you should report a false positive to Netcraft.
You need to contact Netcraft and ask them to remove the site from the list.
thanks guys, i have to contact their sales@ email or?
Don't know, check if there any contact info in their page. | 2019-04-24T11:58:12Z | https://forums.opera.com/topic/16470/phishing-alert/2 |
§ 51-2.1 Unsafe structures and equipment.
§ 51-3 Inspection and report by Code Enforcement Officer.
§ 51-4 Order for action.
§ 51-5 Contents of notice.
§ 51-6 Service of notice.
§ 51-7 Filing of proof of service of notice.
§ 51-9 Refusal to comply; contracts for demolition.
§ 51-10 Assessment of costs; assessment to constitute lien.
§ 51-12 Appointment of surveyor or engineer, compensation.
§ 51-13 Order to vacate premises.
§ 51-14 Corrective action by Village.
§ 51-16 Assessment and lien.
§ 51-17 Transfer of title.
§ 51-18 Penalties for offenses.
Zoning — See Ch. 183.
Unsafe buildings pose a threat to life and property in the Village of Amityville. Buildings and structures may become unsafe by reason of damage by fire, the elements, age or general deterioration. Vacant buildings not properly secured at doorways and windows also serve as an attractive nuisance for young children who may be injured therein, as well as a point of congregation by vagrants and transients. A dilapidated building may also serve as a place of rodent infestation, thereby creating a health menace to the community. It is the purpose of this chapter to provide for the safety, health, protection and general welfare of persons and property in the Village of Amityville by requiring that such unsafe buildings be secured, repaired or demolished and removed.
The Code Enforcement Officer of the Village of Amityville or such other person appointed by the Village to enforce the provisions of this chapter.
When a structure or equipment is found to be unsafe, or unfit for human occupancy, or is found unlawful, such structure shall be condemned pursuant to the provisions of this Code.
Those which, exclusive of the foundation, show 33% or more of damage or deterioration of the supporting member or members, and/or 50% damage or deterioration of the nonsupporting enclosing or outside walls or covering.
Those which have improperly distributed loads upon the floors or roofs or which the same are overloaded or have insufficient strength to be reasonably safe for the purpose used.
Those which have been damaged by fire, flood, wind or other causes so as to have become dangerous to life, safety or the general health and welfare of the occupants, surrounding residents or the public.
Those having inadequate facilities for egress in cases of fire or panic or those having insufficient stairways, elevators, fire escapes or other means of communication.
Those which have parts thereof which are so attached that they may collapse and injure members of the public or the property.
Those which have become or are so dilapidated, decayed, unsafe, unsanitary or which so utterly fail to provide the amenities essential to decent living that they are unfit for human habitation or are likely to cause sickness or disease so as to work injury to the health, safety or general welfare of those living therein or nearby.
Absence of enclosures and/or covers required pursuant to the New York State Building Code, or water causing hazardous conditions.
Deterioration of the pool piping, filtration or water treatment equipment, creating an unsanitary condition in pool waters.
Deterioration or damage to the pool piping, equipment, pool walls or floors causing excessive leaching of pool water into the surrounding ground area.
Improper electrical, water supply or waste removal connections to the swimming pool, or pool equipment creating hazardous conditions.
Improper storage of pool chemicals causing hazardous conditions.
Improper installation of pool heating equipment causing hazardous conditions.
Those elements which, because of their condition, are unsafe, unsanitary or dangerous to the health, safety or general welfare of the people of this Village.
Unsafe equipment. Unsafe equipment includes any boiler, fixture, heating equipment, elevator, moving stairway, electrical wiring or device, flammable liquid containers or other equipment on the premises or within the structure which is in such disrepair or in a condition that such equipment is a hazard to life, health, property or safety of the public or occupants of the premises or structure.
Structure unfit for human occupancy. A structure is unfit for human occupancy whenever such structure is unsafe, unlawful or, because of the degree to which the structure is in disrepair or lacks maintenance, is unsanitary, vermin- or rat-infested, contains filth and contamination, or lacks ventilation, illumination, sanitary or heating facilities or other essential equipment required by this Code, or because the location of the structure constitutes a hazard to the occupants of the structure or the public.
Unlawful structure. An unlawful structure is one found in whole or in part to be occupied by more persons than permitted under this Code, or which was erected, altered or occupied contrary to law.
The Board of Trustees shall thereafter consider such report and by resolution determine, if in its opinion the report so warrants, that such building is unsafe and dangerous, and order that it be secured and boarded up or repaired, if this can be safely done, or that it be demolished and removed, and further order that notice be served upon the persons and in the manner provided herein.
A statement within which the person served with such notice shall commence the securing or removal of such building or equipment as may be necessary to protect the life, safety or health of any person or property.
The date, time and place at which a hearing shall be held before the Board of Trustees, at which hearing the owner or other persons having an interest in the structure or equipment may be heard with respect to the condition of the building, structure or equipment and the actions necessary to secure or remove same.
Said notice shall further state that after such hearing, the Board of Trustees may provide for the securing or removal of such building or structure or equipment by the Village in the event such owner fails or refuses to secure or remove the same within the time provided.
Such notice, together with the report prepared pursuant to § 51-3, shall be posted on the premises, and shall be filed in the office of the Suffolk County Clerk in the same manner as a notice of pendency pursuant to Article 65 of the Civil Practice Law and Rules, and shall be served upon the owner, or one of the owner's executors, legal representatives, agents, lessees or other person having a vested interest in the premises, either personally or by registered mail addressed to their last known address, if any, as shown by the records of the Village Clerk and/or in the office of the Suffolk County Clerk.
A copy of the proof of service of said notice, as provided herein, shall be filed in the office of the Suffolk County Clerk.
The Board of Trustees shall conduct a public hearing at the time and place specified in such notice. The owner, the occupant and any other interested persons shall have a right to be heard. The Code Enforcement Officer and any surveyor or engineer appointed by the Board of Trustees shall submit testimony and/or documentary evidence as to whether the building or structure is unsafe. The Board of Trustees shall consider all competent and relevant evidence and make a determination as to whether such building or structure is unsafe and whether it should be secured, repaired, demolished or removed. The owner, any occupant and such other interested persons shall receive written notice of such determination and any resulting order in accordance with the requirement of § 51-5 hereof.
In the event of the refusal or neglect of the person or entity so notified to comply with said order of the Board of Trustees within seven days, or earlier if conditions require, the Board of Trustees shall direct that such building or structure be secured, repaired or demolished and removed, either by Village employees or by contract, unless such conditions require emergency or immediate remedial action, whereupon the Village shall take such action as may be necessary.
Except in an emergency, any contract for demolition and removal of a building in excess of $20,000 shall be awarded through competitive bidding.
All costs and expenses incurred by the Village of Amityville in connection with the proceedings to remove or secure an unsafe building, unsafe equipment or collapsed structure, including the cost of actually removing said building, equipment or structure, shall be assessed against the land on which said buildings or structures are located. The amount of such cost and expense shall be determined and audited by the Board of Trustees and shall be reported to the Village Assessor as an amount to be levied and assessed against said premises as an assessment for an improvement to be included in the next succeeding assessment roll of the Village of Amityville to be thereafter prepared.
Where it reasonably appears that there is present a clear and imminent danger to the life, safety or health of any person or property, unless an unsafe building is immediately repaired and secured or demolished, the Board of Trustees may, by resolution, authorize the Code Enforcement Officer to immediately cause the repair or demolition of such unsafe building. The expense of such repair or demolition shall be a charge against the land on which it is located and shall be assessed, levied and collected as provided in § 51-10 hereof.
A surveyor or engineer may be appointed to determine if a building or structure is unsafe, and he shall be paid reasonable compensation as shall be fixed by the Board of Trustees.
When there is imminent danger of failure or collapse of a building or structure which endangers life, or when any structure or part of a structure has fallen and life is endangered by the occupation of the structure, or when there is actual or potential danger to the building occupants or those in the proximity of any structure because of explosives, explosive fumes or vapors or the presence of toxic fumes, gases or materials, or operation of defective or dangerous equipment, the occupants shall vacate the premises forthwith. There shall be posted at each entrance to such structure a notice reading as follows: "This Structure is Unsafe and its Occupancy Has Been Prohibited by the Code Enforcement Official." It shall be unlawful for any person to enter such structure except for the purpose of securing the structure, making the required repairs, removing the hazardous condition or demolishing the same.
When there is imminent danger of failure or collapse of a building or structure which endangers life, or when any structure or part of a structure has fallen and life is endangered by the occupation of the structure or when there is actual or potential danger to the building occupants or those in the proximity of any structure because of explosives, explosive fumes or vapors or the presence of toxic fumes, gases or materials, or operation of defective or dangerous equipment, the Building Inspector may take such immediate action as is necessary to protect life and alleviate the danger presented, including emergency repair or removal of all or part of the building or structure, without notice or hearing to the property owner.
Following action taken pursuant to § 51-13, Order to vacate premises, or under § 51-14, Corrective action by Village, the Building Inspector shall prepare and deliver a report of such action to the Board of Trustees, and, if the building or structure remains unsafe, to cause said building or structure to be rendered safe pursuant to § 51-9 hereof. The Building Inspector shall notify the property owner of the emergency actions taken pursuant to the provisions of § 51-6 hereof.
All costs and expenses incurred by the Village of Amityville in connection with emergency measures taken pursuant to an order to vacate premises or corrective action by the Village under §§ 51-13 or 51-14, shall be assessed against the land on which said buildings or structures are located. The amount of such cost and expense shall be determined and audited by the Board of Trustees and shall be reported to the Village Assessor an amount to be levied and assessed against said premises as an assessment for an improvement to be included in the next succeeding assessment roll of the Village of Amityville to be thereafter prepared.
The transfer of title by an owner of the premises upon which an unsafe building or structure or excavation is located shall be no defense to any proceeding or actions already commenced under this chapter.
Any owner upon whom a notice as provided in this chapter has been personally served who fails, neglects or refuses to place such unsafe building or structure or hazard in a safe condition as designated in such notice, or who shall violate any of the provisions of this chapter or orders given pursuant thereto, or who shall resist or obstruct the Building Inspector in carrying out the provisions of this chapter, shall be guilty of a violation and shall, upon conviction thereof, be subject to a fine of not more than $15,000. Each week in which such violation continues shall constitute a separate offense. | 2019-04-21T12:07:21Z | https://www.ecode360.com/6942313 |
The Ohio Union, built in 1910, was the first student union at a public university. In 2004, The OSU Board of Trustees approved plans to construct a $100 million, state-of-the-art student center that would serve future generations of OSU students. While members of the student union leadership staff were ecstatic about the approval, they wanted to ensure the new student union showcase The Ohio State University and serve as a model for other Big 10 schools. The staff estimated that an additional $20 million was necessary to make the new Union “all it could be!” The development team didn’t have any knowledge of how to conduct a capital campaign or a database of donors. Cramer & Associates worked with the leadership staff and conducted a feasibility study to see if there would be enough support for this campaign.
We conducted a feasibility study and interviewed more than 40 individuals who had some type of a connection to the Student Union. Cramer & Associates recommended that the student union leadership team move forward with a campaign and predicted that they could raise between $10 and $15 million. In addition, we recommended a focused and detailed prospect cultivation period. Furthermore, Cramer & Associates recommended a broad-based and inclusive ‘Ohio Union community campaign’ to instill a sense of ownership of the new Ohio Union within The Ohio State Community and throughout the state of Ohio.
Cramer & Associates worked closely with the assistant vice president of student life, to educate and train staff on the prospective engagement opportunities for the new facility. In addition, Cramer & Associates also assisted in the development of an outline of philanthropic areas of support, commemorative opportunities and tactics for personal engagement. | 2019-04-19T02:26:11Z | http://www.cramerphilanthropy.com/casestudy/ohio-state-university-student-union/ |
all seasons, to all classes.
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and French are opposing the Germans.
forty prisoners and a machine gun.
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vate or make you sick.
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build* up the system, jo cents.
the Sixty-fourth congress at noon.
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vents my hearing what you say."
Three sizes, 25c, 50c and $1.00.—Adv.
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g!,„d. hu?.e. and manufacturers sell SI'OHN'S at M cent.
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employ a professional painter, you.
lound City Paint A Color Co.
such power rested entirely with him.
try u box of Doan’s Kidney Pills.
FOSTER-M1LBURN CO., BUFFALO. N. V.
is too valuable; you mustn't Injure It.
lation to those who try It.—Adv.
try will be mobilized in case of war?"
nerve tonic. Price 50c and $1.00.—Adv.
hend for U today. It s Free.
Box 850 Little Rock. Arlc.
guaranteed to remove these homely spots.
rripple with Ids own crutch.
predated member of tne family.
and goodies mad# with K. II. M.
Baking Powder aro always a success.
It once—there is no better.
"Femeuina." Price 50c ami |l.oo—Adv. Send for catalog.
Westfall Drug Co., Kodak Dept.
therefore the beat, delights the housewus.
5 cents to 05 cents u pound.
be sent to President Wilson.
the destruction of the Kingsland, N.
Headache. Used whenever Quinine is needed.
France Cuts Off Many Train*.
The Oklahoma Critic (Tulsa, Okla.), Vol. 1, No. 7, Ed. 1 Tuesday, March 13, 1917, newspaper, March 13, 1917; Tulsa, Oklahoma. (https://gateway.okhistory.org/ark:/67531/metadc1042976/m1/3/: accessed April 19, 2019), The Gateway to Oklahoma History, https://gateway.okhistory.org; crediting Oklahoma Historical Society. | 2019-04-20T00:40:00Z | https://gateway.okhistory.org/ark:/67531/metadc1042976/m1/3/ |
Pocket Hose is the lawn care breakthrough that changed garden hoses forever, and now the number 1 selling expandable hose in the world has been made even better - introducing the new Pocket Hose Ultra! This NEW and IMPROVED version has all of the same qualities you loved, but is now 3 times STRONGER! Pocket Hose Ultra is equipped with tight seal technology, guaranteed to give you a water tight seal every time - no more leaks. The secret is the super strong material of the amber tip connectors that are 3 times more durable than the original! The elastomer hose expands with water pressure, while the new and improved outer lining protects it - no more rips or breakthroughs. And the new Solar Stripe Shield protects Pocket Hose Ultra from damaging UV rays and extends the life of the hose! The improved, super durable Pocket Hose Ultra is built to last for daily, heavy-duty use, and even comes with a LIFETIME GUARANTEE. | 2019-04-21T18:20:42Z | http://www.telebrands.net/product/product.jsp?productID=1292&categoryID=242 |
TWO community radio presenters have been robbed of their broadcasting access after playing an explicit 1980s track on air.
The broadcasting duo of Steve Jankowicz and Haydon Cox was notified via text message their show Jank n the Phatman was cancelled.
It was the 1989 track by No Face titled Hump Music which led to the duo’s dismissal from the station. | 2019-04-24T12:39:20Z | https://borderwatch.com.au/no-love-for-radio-duo/ |
Each and every one of us has been touched by cancer—we’ve lost friends and family, known courageous survivors, and may even personally be one of those brave and strong survivors. So, it gives me great pleasure to share with you that Allstate New Jersey Insurance Company has once again partnered with the Cancer Institute of New Jersey Foundation to raise funds and help find a cure for cancer through our "Quotes for a Cure" program. And you can help, too!
Lending a hand in the fight to cure cancer.
From October 1 through December 1, 2010, Allstate New Jersey will donate $10 for every auto or life insurance quote we complete (up to $20 per person) to the Cancer Institute of New Jersey Foundation up to $25,000. All you have to do is stop by or call my Allstate office at (908) 301-0711 to receive your complementary, no-obligation quote. With a small investment in time, you can get a quote and support the cause! And if you know friends and family who are considering auto or life insurance, please tell them there’s no better time than now to receive a quote from us.
I’m proud of Allstate New Jersey’s commitment to its communities and to its customers. It’s partnerships like these, and ours, that truly make a difference in people’s lives. | 2019-04-22T02:04:56Z | https://www.banskyinsurance.com/blog/partnerships_you_can_take_pride_in.aspx |
Bob Brundage – I’d like you to meet Mr. Bill Heyman a very successful businessman and a very successful entrepreneur of square dancing and we’ll learn more about that as time goes along. So, Bill tell me, well let’s say where you were born and brought up and a little bit about life before square dancing.
BH – turned out he went to Washington State and then on to Hawaii and he became a training officer on Hawaii and actually spent, interestingly enough most of the war in Hawaii and was as with many hundreds of thousands of others an invasionary force going into Japan and he returned to us in 1946 and at that time we moved to Bloomfield, New Jersey, a very small, residential town outside of Newark, New Jersey and during the earliest years when Dad was away the way the women, mother supported us was, among other things, she was a waterfront counselor but again, the reason I mention it is it was at that camp that of course I became interested in square dancing.
BH – When I was three, four and five years old I was at a camp that had a relatively heavy square and folk dancing content at that time and it becomes germane because in 1952 I was twelve years old – that was the summer camp I chose to go back to and I spent the whole summer, at the age of twelve, square dancing.
BB – Ah ha. There you go.
BH – That was really – I only mention this because that’s actually how square dancing got into my blood and I’ve always been a musical kind of guy like dancing in general and that was my initial contact with square dancing and to say that summer actually changed my life is an understatement.
BB – Right. Well, how’s your memory, Bill? Do you have any idea who was calling that summer camp?
BH – The only title of a song that I can remember is “Road To The Isles”.
BH – Yeah, I know but we do that in both folk and square of course.
BB – Well that’s great. So, following that experience then you must have been searching out other places to square dance or did that come later?
BH – Actually it didn’t – it’s sort of interesting because from that point when I was twelve until many, many years later when I was living in Europe I really didn’t square dance not one, not a single time.
BH – Then I came back, finished college, finished graduate school and then a few years later ended up being sent back to Europe for Chemical Bank, a major American bank and ah, what happened was I was in Vienna for five years, Frankfort for three, still didn’t bump into square dancing – I arrived in Zurich, Switzerland as general manager of the branch and there was an American square dance club in Zurich, Switzerland.
Americans who were working overseas, the rest were Swiss, Austrian, Dutch, a few other nationalities mixed in there.
BH – and I started square dancing in I believe early seventy, late seventy seven then shortly thereafter, six months later I expressed my interest in calling and coaching in calling started in seventy eight.
BB – Well, good. OK, and so, these folks were sort of your mentors and were responsible for your basic training so to speak.
BH – and we blended right in to that club and ah, teaching then was actually quite slow. I ended up rotating back to the states about nine months later and we described ourselves as Mainstream minus six.
BH – We hadn’t quite finished the Mainstream list.
BB – Yeah. Right. OK. Well, so did you start actively calling over there – get your own club or anything like that?
BH – It was quite picturesque. It was on the ground floor of a barn – it was absolute horrid middle of winter. It was absolutely freezing. Everybody was square dancing in parkas and I actually had to wear a glove on my mic hand so that my hand wouldn’t stick to the microphone.
BH – Fortunately when the dance ended there was a nice warm living room to which we could retreat.
BH – to teach the class”. So I called my, other than the Basel Club, this was my first tip I had called in the United States and it was through that tip that I ended up becoming the teacher and In September actually started teaching that class – that was my first Mainstream class.
BB – Right, right. Well. Were there any other mentors along the way that you kind of looked up to?
BH – John was very, very influential in setting standards ah; I went to my first caller’s college with Ralph Trout and Cal Golden.
BH – what I need is some technical skills because I really don’t know quite what I’m doing” and he certainly worked on that with me.
BH – and he allowed me copy the whole book.
BB – Unreal. Do you still have it?
BH – I do. I do still have it.
BB – That’s got to be memorialized somewhere.
BH – Because I see, the irony was that here was a rank beginner with very limited skills and was really one of those guys and was long on ?? with one of the icons of square dancing graciously sharing sort of his secret notes with the youngest kid on the block. I was very touched with that.
BB – Great. Well, then ah, somewhere along the line you developed your own clubs?
BB – OK. Well tell me about any big festivals you may have attended like local or national ones.
BH – Sure ah, in my years in Jersey there were maybe – tape clicks and blanks out – ninety, I finished the ninety two, ninety three teaching season – no it was the ninety one, ninety two teaching season and at the end of ninety two I knew I was going out of New Jersey probably to New England and made provision not to accept the class the next year and then ??? – that wasn’t fair.
BB – What about ah, festivals and things like that did you attend any of the Nationals or Regionals?
BH – Yeah, but not actually as a caller. I went to our first National with ??? – I believe that was eighty four.
BB – festivals you may have attended – any Nationals or any of the regional ones?
BH – As far as local ones we had the usual callers association or dancers associations sponsored at which I called. I was one of multiple callers I never had anything by myself in that area. Had the pleasure of doing the Grand March at one of the New Jersey State Conventions. I had one hundred and twenty squares. That was, that was the largest group of people that I ever called for, was actually, was actually called an exciting moment in my life.
BH – I can’t tell you how pleased I was – and again, it was most incredible. As far as the National Conventions, we started with the at the Nationals in eighty four (?) – it was in Baltimore then – coughs – Excuse Me – and we were there at that time primarily as vendors but I decided that since I was already a caller and had certain skill level I certainly could call a comfortable Mainstream so I signed up to do Mainstream calling and I did, I don’t know – three four, five ah, different calls in different time zones – minor time spots usually like, twelve-thirty in the whatever room – right in the middle of lunch hour, etc. which was frankly probably for my skill level highly appropriate.
BH – without exception and ah, partially we have to for the businesses – for the businesses if you miss any one you are out of the convention and ah, during the, pretty much the first ten years of that I was on the Executive Committee of the National Association of Square and Round Dance Suppliers, eventually became President of the Ethics Committee Chairman for four or five years also.
BB – So ah, how did we get into that, ah, tell us a little bit about where you’ve been going with that and what your plans are for the future.
BH – the ones with the twelve volt batteries. Anybody who has owned a ?? knew, knows the problem with an expensive batteries. So, we actually started with eight cord (?) microphones and then I went to a case manufacturer and designed a case for them. I was working with a box full of records – forty-five RPM records – laid them out, I had my microphones with me and I said, “I need a case that will contain all of these records” and we designed that case. That was in nineteen eighty-two and to this day we are still selling the same case and we had to do a warranty replacement which was what we designed then turned out to be a good little product and ah, Peggy was really doing that full time and then Mike ?? was our division head, in charge of the retail branch, our branch was in lower Manhattan but with Chemical Bank, it was career-wise really time for me to bail out and my career had, at best five ??. I got out and I really went full time with Peggy in nineteen eighty-five. I’ve been working full time in the business ever since then. Once again, we started off as pure caller and cuer supply house – it was caller’s corner, cuer’s corner was how we started. Then in ah, that was eighty-two started that way, in eighty-three I guess it was ah, Jean ??
ah, back with me, excuse me Bob ?? was the owner of Supreme Audio passed away very suddenly and ?? speakers ??? ended up purchasing Supreme Audio and had it driven up by truck to, to our house in New Jersey and then in nineteen eighty-seven I bought Hanhurst’s Tape and Record Service from Don and Loretta Hanhurst ah, then in Venice, Florida but have since moved and so by nineteen eighty-seven we had become the largest supplier in the square dance industry. Also during that time we had expanded into Tap. Jazz, Ballet community because we took the variable-speed ??
BH – and ah, that evolved over time and now square dancing is exactly one-third of our business and Tap, Jazz, Ballet and primarily Fitness is two-thirds ?? schools of dance, University Dance Departments on the fitness side on the ?? University Fitness Facility and we ah, sell to most of the United States Military Fitness Facilities around the world. There’s a lot of ??
BB – All right. This I didn’t know. That’s very interesting. I know you told me the last time I saw you at your home ah, that you were doing a considerable business with Government agencies. I didn’t realize what it entailed.
BH – Actually, as a single segment it is actually the most important segment other that square dancing.
BH – Number two behind square dancing.
BB – Right, so, but you’re not actually calling any more.
BH – there is a wonderful, wonderful community of callers up there. We’re pretty active in that also.
BB – but you are doing, I think you still do some one-night stands.
BH – so basically I haven’t been calling actively now for nine years.
BH – They really went hand in hand. I thought the one-night stands were a wonderful way to introduce people to square dancing. I could not give you a statistic as to how many people came out of those one-night stands and joined the activity as we know it but it was always fun to do and ah, I really, if I would ever start again I would actually probably do exclusively one-night stands and fun nights.
BB – Hmm. Well, that makes sense the way the activity is going.
BH – Well, to ah, quote my good friend, Jim Mayo actually ?? ? alone ah, one really has to be so much ?? as to where the curve or the trends of the activity are going and realistically we can’t – we don’t have the ?? interesting to do something that is totally contrary to the curve, if you will of the activity level curve of where the society ??? being pragmatic about doing that ah, the trend that we have seen between Callerlab and the current thought is I think finally in the right direction and that is really the simplified – I have been a proponent of this for years now. I felt that the risk structure, the way they are they really forces a lot of people to move on – it is human nature to, to go, quote, higher levels and that is popular and that’s in fact what they do and as it’s human nature that will drive people out there and I think what they have to offer is the Basic program, the old Basic program as it was simply did not work. It just did not work in that structure but I think that where we are going now at least had the beginnings of ah, common sense. One of the things that I think was very supportive spiritually and frankly, financially was the whole marketing research effort that was put on by Callerlab. Many years ago I came up with the slogan, “Excellence through Education” which was actually adopted by Callerlab at one of their conventions ??? They, they used a somewhat different version of it but I’ve always felt that ah, this square dance calling really means two fundamental things – good calling starts with good heart – I think that a good person with really good feelings and good feelings toward fellow man and ah, good education because I really feel that a good education is a cornerstone of this whole thing and, for that very reason we also sometimes tend to make public pronouncements of how I feel about things. I also back that up with money. I have been giving scholarships to caller’s schools for twelve or thirteen years now. I think we began to give in nineteen fifty-eight or fifty-nine and so far Peg and I have paid out of our own pocket and there are partial scholarships especially for three or four people each year who have ?? and ah, we also have decided that we believe strongly enough in that we have to help pay for the cost of it and ?? scholarships, there are certainly other scholarships available, especially through Callerlab and many other local callers associations and the other thing that I do is when I do seminars, I do fair amount of seminars every year at callers associations ah, and I do at least three or four a year I have never accepted a fee for that although they ?? I have always said to them, “Take the hundred or two hundred you would have paid me, put it into your scholarship fund and you’ll have an extra scholarship this year” – that’s where I would rather than see money come into my pocket. I frankly rather see ??
BB – Ah, that’s very interesting. Ah, what’s your opinion of modern day caller’s schools ah, maybe I should tell you a little bit of my opinion. There’s so much, so much emphasis on choreography that ah, we’re getting away from teaching people how to dance, or we have gotten away from it and ah, do you have any thoughts along that line.
BH – and as we all know the tens of millions of dollars raised around the country our caller’s association down there had a big dance out at Liberty State Park and we had a thousand dancers, once again purely raising money, I actually sounded the whole thing for free, I had a lot of fun with the help of a friend, Bill Anderson and ah, so we raised money for that and then for the actual rededication ceremony on that day there was a three-hour ABC television broadcast on the air and the long and short of it is that I was selected to do the broadcast and I was in front of eighty million people, Bill Heyman, Liberty Square Dance Caller and so forth.
BH – The reason I tell the story is we, that being at that dance caused me to be a day late for my caller’s college.
BH – My point of telling you this, that I went from the National chance to go to caller’s college to learn more about calling.
BH – it was dreadful, the class took two and a half hours, the critique took three hours.
BH – so it was really dreadful. Ah, but coming back to the key point of caller’s colleges, the one college with which I was most ?? was the Johnston-Brundage in Massachusetts which is now, as you well know run by ah, Randy Page and Mike Jacobs.
BH – it’s all on one page and there’s a link right from the very front page that people looking for callers schools, it’s right there and at the bottom the scholarship information, it’s got the Callerlab web site and their scholarship page ?? scholarship ??
BB – Ah, have you any thought s about the ah, so called CDP program, ah Community Dance Program per se. I’m talking about the ah, this is a very limited program of what, I think twenty-five basics are proposed and so forth. Do you see any future for that type of program?
BH – and ah, you know in a real, in a real solid manner – I know there, there are people, you know the Bob Howells and the Jerry Helts ?? we all know the names of people, Cal Campbell obviously has written a lot of the literature on it ah, but that is a very limited, I think a limited teaching population and I think we can even on the marketing side I think they have some, some, some ah, ah, issues there what, what I think where a few are headed and I believe if I understand it correctly is that it will be basically a pure square dance program, that doesn’t mean without any contras but not just not as a ah, high content as I believe has been in the past and to get people doing more fun night type squares in other words without this long, long teaching obligation and without the long term commitment to, you know, if you don’t go one week you’re going to be falling behind and you’ll never get back into dancing. That is a ah, that is ?? and then you have to comment on the multi cycle theory because I am, I am a big proponent, I’ve never done it ?? teaching ?? I attended at this last Callerlab Convention the multi cycle session, very good, there were eighty people in the room, it was a terrific session and I had a lot of promotion of that on the web site too, an article written by Nasser Shukyr and Mike Seastrom and a couple of others where, wherever this program has been seriously pursued success has happened.
BH – so I probably have really more time on that dance floor, back in the fifties, back in the forties and fifties, I probably have more time in the traditional and I have great respect for both the traditional groups but I am pretty well ensconced in the ah, Modern Western side of the world.
BB – That’s interesting. I was on staff at Pine Woods for a few years – way back – a tremendous program of course, all live music and – do you see any future for live music?
BH – that is a wonderful gotta, gotta dance music and was, that was actually one of my, one of my couple of fondest memories of the, coming to the dance hall a little bit late and hearing that music coming out of the ??
BB – and Ladies Chain, Ladies Chain all night, Ladies Chain, Ladies Chain period and today’s dancers never, never fathom trying to get through a figure that way but, they knew how to do a Ladies Chain when they got through.
BB – It’s been a tremendous contribution to the activity – no doubt about it. Ah, anything you’d like to add?
BH – I, just as anybody else who is in the circle Peggy and I have a really deep love for square dancing ah, I must say, a somewhat successful career – I don’t want to make it sound bigger than it was because it is obviously it was early eighties and careers had a lot of problems then ah, but I really did leave a high paying job to do this ah, I’ve learned to live with less money, that’s my – not been a problem for us and it’s even less now that dancing is down due to the recession, of course I have a business that was forced down quite a bit ah, but ah, we continue to do the things that are important to us ah, square dancing is certainly not our only volunteer activity we’re very involved in, Board of directors, Peggy is on the Board of the New Hampshire Dance Institute –spends a lot of time in there also we’re financially supportive there of ?? dance program for kids who might not be exposed to dance. Otherwise, we’re very involved in that and I actually just joined the Colonial Theatre Board of Directors which is the local restored antique movie theatre – a typical nineteen twenties movie theatre – typical to many, many old New England and other cities of course and ninety-nine years old now and, in fact this year we had our first ?? year so we’re very involved in their programs trying to help them – we’ve also done some fund raising for the ?? Orchestra when they had a house concert so Peggy and I are not only involved in square dancing but we’re involved in other areas in the community and I just did a web site for the Town of Marlborough and I’m their webmaster – we do a lot of volunteer things, a lot of fun things – I’m on the Conservation Commission – we have about nine different activities going that keep us happy and busy.
BB – You’re tuned in all around New England then. | 2019-04-19T22:24:18Z | http://www.sdfne.org/bill-heyman/ |
When we speak about brides beauty, elegance and quality are key words and choosing a professional that uses the best products and techniques and that understands how important this day is to you is vital. It's important that your makeup and hair reflects exactly how you want to feel on such important day and perfectly match your style, personality, dress and accessories. From head to toe the bride must feel absolutely beautiful and you and your desires are our priority! We always advice our brides to do a trial first and we are totally available to go to you on the comfort of your house or hotel. It will also be a pleasure to receive you and your friends on our store for the trial. Trials don't have limit time the important thing is that you feel that you made the right choice and feels absolutely beautiful. We also apply fake eyelashes on the trial and on the day of the ceremony if you want. On the day of the ceremony we are there for you, to make sure that everything goes as is planned, and we will stay with you until when you want. We can also do your guests hair and makeup and fake eyelashes are inclued. | 2019-04-22T08:28:54Z | https://ibride.com/packages/loule-sao-clemente--portugal/beauty-hair-and-makeup/ |
Whenever the sunflower is predominant the honey is pure. If there happens to be any harmful substances, like pollutants in the soil, they don’t reach the flower. The reason for this is because the plant actually retains them in the stems. This means the nectar that the bees gather is 100 percent unspoiled.
Bees can't get enough of the oily sunflower. It's not like they can miss this large, brightly colored plant, which drowns out all other blooms calling for attention. In fact, some plants can get as tall as 14 feet though the average is around nine feet. Add to this their bright yellow petals and it’s easy to see how they can dominate. The sunflower blooms around July in a typical year and last for about 20 days give or take a day or two either side. The warmer the day, the more nectar the flower secretes. Because sunflowers are such large daisies, they produce a lot more nectar than any of the smaller plants.
Sunflower honey is popular in both sweet and savory baking. Some people enjoy the honey drizzled over fruit, or to add a little something extra to cheese or yogurt. It's also popular as a natural sweetener.
Health benefits of this honey are similar to that of most other honeys. Some people who have used it for medicinal purposes swear by its effectiveness. Others are more skeptical. There is quite a bit of ongoing research into most of the popular honeys, though the scientific community has not yet confirmed many of the claims. Even so, sunflower honey, like other honeys, shows a lot of promise in regard to its medicinal properties. Here are a few of the health claims for this particular variety.
Further reading of interest: As pointed out in the opening paragraph, sunflowers can hold all contaminants from the soil in their stems. It's not like this for many other plants though. The scientific study below looks at the pesticides that can get into some honeys.
Pesticides in honey: A review on chromatographic analytical methods.
Souza Tette PA, Rocha Guidi L, de Abreu Glória MB, Fernandes C.
Sunflower honey is well-respected in the world as a quality produce. The biggest manufacturers of this honey are France and Spain, though some other countries also produce it too. It has good antioxidant properties, like other honeys, which makes it a good natural treatment for common colds, sore throats and for easing flu symptoms. Anyone who enjoys sweeter honeys will find a place for sunflower at their table. | 2019-04-22T16:08:23Z | https://secretsofthebees.com/blog/pure-sunflower-honey-characteristics-uses/ |
I'm about to tell you a true story. It's not about me (honest). I have this friend who submitted an application to Apple for review. After a few weeks, it came back with one of those embarrassingly stupid rejection letters that said more about the person reviewing the application than it did about the application itself. In a nutshell, the application violated one of those user interaction rules that seem to exist in certain pompous minds rather than in the actual Apple Human Interface Guidelines.
My friend wrote to me and blew off a lot of steam. This was not by far the first rejection letter received by said person. And this person had a history of frustration. Apple had, at no time, replied to a single protest letter written by this person or provided any way to appeal rejections. So here's where it gets interesting. After a day or so of calming down, this person decided to go ahead and resubmit the application. And did so without making a single change to the application.
I'm sure you know where this is going. If you think for just a second, you'll figure out the punch line, and you'll be right: that application was accepted into the store, exactly as is, without any changes whatsoever. It is for sale today, and you can go to App Store and buy it.
It's stories like this that highlight the arbitrary and capricious nature of some App Store rejections. And, should you be a developer, it may provide you with some courage to stand by your design, exactly as it is. Because sometimes if you fail at first, you may yet succeed if you try, try again. | 2019-04-19T15:21:38Z | https://arstechnica.com/gadgets/2008/11/app-store-lessons-try-and-try-again/ |
At the time of the last Lintian run, the following possible problems were found in packages maintained by Geza Kovacs <gkovacs@mit.edu>, listed by source package. See also the full report, including info, experimental and overridden tags. Also see their QA overview. | 2019-04-19T12:41:34Z | https://lintian.debian.org/maintainer/gkovacs@mit.edu.html |
SHIFTWEAR SNEAKERS – FOOTWEAR WITH ANIMATED FLEXIBLE ELECTRONIC E-INK DISPLAYS THAT CHANGE DESIGNS VIA MOBILE APP!
12 Weird Celeb Purchases That Will Make You Think, WTF!
THE SEABREACHER SAILFISH IS HALF JET SKI, AND HALF SUBMARINE – ONLY $100,000!
Japanese Mini Segway The “WalkCar” – Never Walk Again!
Is Your Phone, Built For You? | 2019-04-18T13:05:33Z | https://www.chaostrophic.com/category/gear/ |
5959 Staples, Suite 211, Corpus Christi, TX 78413.
Call the office for issues regarding HOA code compliance or health and welfare issues (not responsible for 911 emergency response calls).
Kings Crossing Security Officers: Paul Janko, Braden Tackett, Michael Munoz. Send security or safety concerns to these officers via our HOA Security Committee by filling out the Security/Safety Report Form on our Website. If you have a security issue that is not an emergency, please contact the CCPD non-emergency number listed below. If you have an actual security emergency, you should dial 911.
City of Corpus Christi Problem Reporting: use the phone number below to report issues regarding street problems/repair, safety concerns, utilities, animal care, code enforcement, solid waste or graffiti.
Click here for the City of Corpus Christi Website.
Click here to submit a service request to the City. | 2019-04-19T01:19:35Z | https://www.kingscrossinghoa.com/info.php?pnum=23 |
Inspecting a used car for flood damage.
Hurricanes Harvey and Irma have made way through the states, leaving many used cars damaged by floods. It is estimated that over 300,000 claims will be filed with insurance companies for flood damaged vehicles. As it is not illegal to sell these vehicles, there is a good chance many of these vehicles will end up in the used car market through auctions and salvage yards. Considering some loop holes in the reporting agencies, there is a good chance some of these cars will end up in our market without being titled as flood damaged.
Check the history report: Many car title and history reporting companies will include a check for flood damage based on insurance records. This is a good first step to checking for history of flooding or what states the title has be transferred to. Although there are ways to avoid flood damage being reported, multiple title changes in a short period of time should raise some questions.
What’s that smell?: Even though a flooded car goes through multiple stages of reconditioning, one thing that is almost impossible to remove is that moldy foul smell of lingering bacteria infested waters! Make sure you check for any unusual odors in the car (especially the trunk and the heat or A/C).
Stains and rust spots: Even though most interior parts get replaced or cleaned after a used car has been flooded, there are always small signs that raise suspicion of water damage. Thoroughly check the interior for unusual water stains and check all metal parts in the interior for signs of excessive rust like under the seats or behind kick panels. Inspect the car’s exterior for rust spots as well. Make sure to look underneath the car and also look at any visible bolts for unusual rust.
Make sure everything works: Finally, make sure you test that everything works the way it’s designed to. For example, if a seat won’t move and there is rust on the track, that could be a good indicator of water damage. Make sure all the lights and switches work. Look for unexplainable occurrences when inspecting everything (like things intermittently going on and off). Drive the car and makes sure there are no abnormal noises coming for you engine and transmission.
There is no doubt that some of these flood vehicles will end up in used car lots across the country. It is best to always buy from a reputable used car dealer, but if you are unsure or have any doubts, inspecting a used car with a professional is always a good idea.
Book your pre purchase inspection in San Diego, NYC, New Jersey and Philadelphia today! | 2019-04-21T20:26:25Z | https://motovise.com/inspecting-a-used-car-for-flood-damage/ |
Can you watch dvds on an xbox one?
What is the order of the marvel movies that i should watch them in?
so as recently as last year i became a marvel fan and i only saw a couple of marvel movies and i want to see them all but in order and i want to watch them in time order and not by the year they came out in so does anybody know the timeline order of the movies i should watch them in.
I know i have been saying alot but i mean it i really hate everybody?
i really hate everybody including my parents.everybody treats me like garbage and i hate everybody that exists on this planet and i wish i was never born. i really hate everybody i know ive said it in a couple questions on here but i mean it i really do hate everybody.
I really hate everybody still they are ******* idiots?
again at school today people were passing by me but way too close and i was trying to go around this group of three guys in the halls and they kept cutting me off and blocking my path past them.also ones of them pushed the other one and they almost bumped into me and knocked me down. i really hate people i really cant stand them anymore. everybody just pisses me off and annoys me and i hate people so much. i cant stand people anymore i hate every single f***ing person. i dont want to marry anyone at all and have kids with anyone because i hate everybody. im done with life and i hate my life. why do people have to be so mean to me and make me miserable. i am so done with people i hate everybody and i want to just lock myself in my room away from people and be antisocial and i dont care because i hate everybody.i hate girls and guys, i hate my friends and other students at my school and i hate my teachers.
How come the 4 episodes of loud house from march are not on the nickelodeon app is there anyway i could watch them?
What are some good ways to lose fat from food or stay skinny like i am?
I feel like i was born as a mistake?
the reason why i say that is i am a boy but i feel like i was really meant to be a girl because i am always acting like a girl and putting my hands on my hips and doing the girl hand motions. i mean it could jut be a coincidence since i have mainly all girl cousins and only one boy cousin on my dads side but im not really sure i am really conflicted on what the reason for it could be.
If i have dark thoughts of wanting to kill or hurt someone that means hell right?
Does pokemon lets go eevee and pikachu work on the regular nintendo switch or just the pokemon lets eevee and pikachu nintendo switch?
I am so stressing out right now?
so today i told my friend that i didnt want to be friends with her anymore and now i am stressing out that she is gonna tell my teacher and my teacher is gonna try and make us become friends again but i dont want to because i dont want to be her friend anymore she is really annoying and i hate her so much which is why i no longer wanted to be friends with her. im crying because i dont want someone to force me to be friends with her if i dont want to be friends with her anymore.
Is it weird that i dont feel attracted to either guys or girls?
I think my friend still has feelings for me beause she still does things that look like she does what should i do?
so i think my friend might still have feelings for me after i told her i dont and never will feel the same way about her because i just see her as a friend and thats the truth and ever since then she has still been doing things that make me think she still does and it makes me upset because it makes me feel likes she does not care that i dont feel the same way about her and still wants to feel the same way about me even though i dont. i am gonna be completely honest and say that i never see us in the future being together or having kids together and i dont want her to think we will ever be together or have kids cause we will not i only see her as a friend and thats the truth. i dont see her at all in my future. also i really have never liked her at all as friend either. ever since we both started becoming friends at the beginning of the year i have been annoyed with her and hated her and have only just been sucking it up and being nice to her. i really dont like like her and i dont like her as a friend either. what should i do because i want to be free to like other girls but i dont want her to ruin my life or chances with another girl at all in the future.
Which one of these books should i read on my kindle?
What should i do because i am really starting to get pissed off by my friend?
so there is this girl who i just see as a friend and she told me she like liked me and i handle it nicely and told her i just want to be friends and i dont and never will feel that way about her. now i am afraid she does still and is gonna get jealous when she sees me with another girl and ruin my chances with that girl and any other girl. i dont want her to do that because i made it obvious i dont feel that way about her and never will. i dont also want her to be single because we did not end up dating and get upset and not want to be with anyone else but me even though i told her i dont like like her like that. i clearly am not into her and i dont want her ruining my chances with another girl because she still has feelings for me and will get jealous when shes me with another girl and tries to ruin my chances with that other girl. like there are other fish in the sea that she could find i dont know why she has to be obssessed with me after i told her i dont and never will be together. i clearly dont see us being together in the future ever. what should i do?
Anybody know when supernatural season 14 will be on netflix and also when legacies will be on netflix?
I am really worried right now and feel like everybody believes the lie and not the truth what should i do about it?
so in February my friend who i just liked as a friend told me she like liked me and i handled it at first nicely telling her i just want to be friends with her because i just liked her as a friend and then we agreed on being friends. Thats where i should have just stopped but i didnt i ended up lying and telling her i was gay. Later on i decided for some stupid reason to go along with my own lie which again is a lie because i am into girls and not into other guys. I then told all my friends my lie that i was gay and they all believed me and then as recently as this Tuesday my one friend took my lie way to far and hooked me up with a gay guy from another high school she is friends with. When he started calling me hun and cute thats when i felt like i had to tell the truth cause i did not mean for my lie about being gay to go this far. So i told the guy i wasnt gay and was just lying because i panicked and told my friend who said she like liked me that i was gay. Then i told my friends the truth i was just lying about being gay because there are some girls i just like as friends and some girls i like as more than friends. Now i feel like my friends instead of believing the truth about me actually being straight or whatever the word is for liking girls is a lie even though its the truth and that im actually gay and just lying about liking girls. I regret lying about being gay and wish i can take it all back but i cant. i have always liked girls my entire life always have/will.
Should i just have a secret crush on her?
so my teacher at my high school has a daughter who is a freshman at my school and i find her very hot and i have a serious crush on her like thats all i can think about is her and obviously i am 19. so should i just have a crush on her since obviously she is way younger than me and im way too old for her. | 2019-04-21T04:29:46Z | https://au.answers.yahoo.com/activity/questions?show=PFJ7NADXPQ7BJNXKQEEV6KTYIM&t=g |
Whilst the cuts to public libraries within the UK have attracted significant column inches in recent years, as a discipline, library and information science is not often in the news. Whilst stemming from the ancient, socio-political stance that preservation of, and access to, the record is ‘a good thing’, historically, this has been rather taken for granted. Library and information science is not an outstandingly popular subject in the UK, and salaries for information professionals are modest. A colleague of mine pointed out that he would love for school children to say ‘when I grow up, I want to be a librarian’, but LIS clings stubbornly to its reputation as a subject with limitations.
I am prompted to comment now, as we are living in somewhat extraordinary times. Where it seems there is a real chance that facts have become what we read on a state controlled social media. Where Orwell’s 1984 has sold out on Amazon, and yet prejudice, hatred and willful consumption of disinformation has never been greater. My Twitter dashboard is filled with anxiety and political commentary pretty much overnight, in response to the US Executive Order on immigration.
So I would like to take a moment to mention our work in Library & Information Science at City, University of London. Our London Library School, CityLIS, has grown from the first course to be offered in Information Science, in 1961. We have always welcomed those interested in any aspect of the information communication chain, irrespective of personal background or academic discipline. CityLIS is an international, interdisciplinary cohort, which collectively supports and works towards the understanding of information and documentation, from micro-blogging, through physical and digital books, papers, journals, creative outputs and commentary in any format, to high-level analysis. We work towards the preservation of, access to, and understanding of humanity’s record.
Library and information science skills are essential not only for those who aspire to work in a library, or information office. They form the bedrock of understanding to those pursuing an academic career, to those working in the media, to those promoting humanitarian causes, to those teaching, to those in the caring professions, to those in the creative industries, to those working in businesses, to those with leisure interests. Library and information science skills are essential to everyone who inhabits civilized society.
Library and information science is a broad field of study, which focuses on the topic of information, and which draws from a plethora of approaches, including those of computer science, human computer interaction, media studies, cultural studies, psychology, linguistics, education, history and philosophy.
The communication of information is the heart and soul of our information society.
The mechanisms and instantiations of our record are continually evolving in response to technology, politics, socio-cultural mores, and economics. At CityLIS we also emphasize ethics. We base our understanding and development of processes of the information communication chain on history and philosophy, especially the work of Karl Popper, Luciano Floridi and the developing approach of the Turing Institute.
CityLIS promotes library and information science as an important, independent discipline, which supports progress in all other disciplines. We welcome students and colleagues who wish to work for an open, rational and educated society.
Are School Exams Really Dumbed Down ?
I rarely meet a student interested in science. I am curious as to why science has such bad press.
Maybe nobody teaches it with enthusiasm. Maybe nobody wants to teach it full stop. Maybe nobody is inspired by it. Maybe it is just too hard.
Very few of our LS or IS students wish to specialise in science information.
“1. Our moon seems to disappear during an eclipse. Some people say this is because an old lady covers the moon with her cloak. She does this so that thieves cannot steal the shiny coins on the surface. Which of these would help scientists to prove or disprove this idea?
3. The female nurse leaves the room while the X-ray photograph is being taken. Why must she leave the room?
4. When we sweat, water leaves the body through?
5. Sandy is a warden for a conservation group. He notices that there are fewer sea birds nesting on the cliffs this year than in previous years. He is worried that some species of birds may die out. Which word is used to describe a species which has died out?
Just for interest, I retrieved my ‘O’ level physics book from the shelf.
“6. State Newton’s laws of motion and explain how one of them may be used to define the absolute unit of force in the SI system.
There are 18 questions in all, but I won’t go on. My father always used to tell me that things were much harder in his day. But I wonder if they really were much harder in my day?
Of course the major point of newspapers is to sell newspapers. And maybe the questions listed are merely a taster of what a science GCSE candidate has to know to pass. | 2019-04-20T14:12:20Z | https://thelynxiblog.com/tag/education/ |
WARNING... This is going to be long. You enter the home into a foyer with ceramic flooring and enter the HUGE living room with fireplace. The kitchen is to absolutely die for...The gourmet kitchen features over-sized gas stove, granite counter tops, wine cooler, walk-in dbl door pantry, over the top sized island (the island was designed to have adequate room so if someone needed a wheelchair), all stainless steel appliances. Intercom system throughout. Hardwood floors, formal dining room and MASTER WITH FIREPLACE.Outside features an in-ground heated pool, fenced area with patio for grilling, over 5 acres, fruit trees to include: apple, pear, figs, and peaches. (2) 2 car garages with several storage spaces.2ND LIVING QUARTERS include a sitting area, FULL KITCHEN, bedroom and bath with walk-in shower. | 2019-04-19T13:22:10Z | https://www.charlottelakenormanhomesales.com/homes/1375-Saint-Paul-Church-Road/Clover/SC/29710/90863140/ |
The Arctic and Antarctic are bellwethers of our planet’s health, and they are undergoing rapid and dramatic change due to globalization, climate change and other human activities. In pursuit of a sustainable future for these regions, the University of Washington is capitalizing on our incredible expertise by investing in research, education and outreach to help us further understand and address the changes we are currently witnessing.
Our planet’s high latitude environments—the Arctic and the Antarctic—are experiencing rapid, multifaceted and complex changes. The disappearance of ice is one aspect of change that drives many others, affecting critical social, economic, political and environmental systems. The Polar Regions are brimming with natural resources and contain vast repositories of historical data. They are home to nearly 4 million people and play a role in the national security of many countries. Equally important, they are visually breathtaking and have captured imaginations and inspired pioneers from its first people to modern-day scientists.
Their sheer distance from the major populations centers of Earth’s more temperate and tropical latitudes can put these places out of sight and out of mind, yet their health—from social to environmental—has deep implications not only for their own region, but for the entire globe.
The University of Washington has built a leadership position in polar research over the past 40 years and already has unparalleled programs in the natural science, social science and policy of the polar regions. In an effort to better understand the changing systems of our planet’s high latitudes, the College of the Environment and other a number of UW units are investing in current and expanded polar research, educational resources to develop future leaders in science and policy and outreach activities that bring the story of the poles to our doorsteps.
New investments in faculty and research are being made, accelerating research and continuing to advance our leadership in polar studies.
Emerging collaborations across disciplines—natural sciences, social sciences, humanities, arts, policy and more—are building needed knowledge about the intersections of these complex areas.
A new distinguished postdoctoral program is being launched, supported by the Quaternary Research Center, the Applied Physics Laboratory and the College of the Environment, providing resources for the best and brightest early career scholars.
A new investment to the Jackson School of International Studies from the Andrew Mellon Foundation, will invigorate social sciences and policy studies in the Arctic.
A new Fulbright fellowship program has been established, bringing distinguished visitors from Canada to the UW campus for an extended period of time.
A new Arctic Studies Minor, coordinated by the Jackson School for International Studies and the School of Oceanography, provides undergraduates with opportunities to gain skills relevant to addressing major science and policy issues connected to the Arctic.
UW offers numerous graduate level classes focused on or highly relevant to the Polar Regions, including a new seminar—offered jointly by faculty from Anthropology, Canadian Studies and Oceanography—that introduces students to interdisciplinary, policy-relevant themes with faculty and students from diverse fields of study.
Students, faculty, staff and the public have the opportunity each year to learn from a visiting scholar from Canada under The Canada Fulbright Visiting Chair in Arctic Studies program. The Chair brings scholars, scientists, practitioners and leaders involved in Arctic affairs to the University of Washington to build new synergies among those working in the circumpolar North and to reinforce relations between UW and Canadian scholars.
The Future of Ice Initiative is possible because of strong partnerships between the College of the Environment, College of Arts & Sciences, Canadian Studies Center at the Henry M. Jackson School of International Studies, Polar Science Center at the Applied Physics Laboratory, Quaternary Research Center, Program on Climate Change and more.
A number of private foundations, artists, independent scholars and others have supported the Future of Ice Initiative, with the goal of providing opportunities to extend academic work beyond the UW, and work collaboratively with people and institutions doing real-world work in the polar regions.
Learn more on the Future of Ice website. | 2019-04-25T21:50:05Z | https://environment.uw.edu/research/major-initiatives/future-of-ice/ |
Coca-Cola has once again delved into the '90s archives to bring back a nostalgic favorite.
Seven months ahead of the release of the new "Ghostbusters" film, Coca-Cola could be rolling out an old favorite: Hi-C Ecto Cooler.
The company filed a trademark patent in September for the orange-tangerine flavored drink, which was approved in November.
Great Scott! This much for a Pepsi?
Ecto Cooler, colored green in honor of Slimer from the first "Ghostbuster" film, debuted in 1987 in partnership with the franchise's cartoon series. The beverage lasted long after the 1991 cancellation of the show and was available until 2001 before being renamed "Shoutin' Orange Green."
Ultimately, the drink left shelves in 2007 after being renamed again. However, fans of the beverage resurrected Ecto Cooler with their own recipe in 2011.
This isn't the first time that Coca-Cola has gone into their beverage archives and brought back a fan favorite. In September the company brought back Surge, a popular citrus-flavored soda.
Competitor Pepsi has also doubled-down on the nostalgia market. The company released Pepsi Perfect in October in honor of "Back the the Future" Day. | 2019-04-19T02:39:14Z | https://www.cnbc.com/2015/11/27/coca-cola-rolls-out-hi-e-ecto-cooler.html |
Here are this week’s interesting media and publishing stories. Add your favorites to the comments section.
Tagged with apps, books, business, Facebook, grammar, lifehack, media, publishing, Social Media Daily Facebook, technology, Twitter, writing, Yahoo!
Here are some of my favorite stories and news items from this week’s publishing, media, and tech reporting.
Lots of interesting media, tech, and publishing news this week. Here are just a few things that caught my eye.
Here are just a few things in the media and publishing world that caught my eye this week. Add your favorites in the comments section.
Here’s this week’s tech, media, and book publishing news.
Here’s the week’s interesting tech and publishing news. | 2019-04-21T10:30:56Z | https://gabistan.wordpress.com/category/link-roundup/ |
Caplugs is a specialist provider of product protection parts, operating from Tewkesbury in the UK where we carry extensive product stocks, and offer first class service back-up.
We handle over 8000 different products so if you cannot find exactly what you require please call us on +44(0)1684 533 800 or use the "Enquire Now" button above, and we will do our best to understand your application, and supply you with the details of a selection of products that we trust will meet your needs.
While we like and welcome large quantity orders, we also operate a webshop – www.CapXpress.co.uk – where, for credit card payment only – a selection of products is available in small quantities with next day delivery.
For our non-UK customers we are able to quote and invoice in Euros. We also offer an express delivery service to most countries within the EU.
Caplugs was established in the UK in 1990 and is a division of Verton Limited T/A Greentree which acquired it in March 2013. | 2019-04-20T12:56:38Z | http://caplugs.co.uk/default.asp?pg=aboutus |
This squad will travel to Tubbercurry on Saturday next 04/10 evening 25/09 to take part in a blitz day. This will give all players a chance to experience playing against teams from Roscommon, Sligo and Fermanagh and should prove to be very enjoyable. Bus routes and times are as follows. Manorhamilton 8.50, Drumkeerin 9.10, Drumshanbo 9.30, Ck-on-Shannon 9.45. Ballinamore 8.30, Carrigallen 8.50, Aughavas 9.05, Cloone 9.15, Mohill 9.25, Masonite 9.35, Ck-on-Shannon 9.45. For further information players should contact Cormac Flynn on 087-6787716.
Under 15 squad resumes on Saturday morning next in Kiltubrid GAA park, commencing at 11.30 am. Bus times and routes as follows.
Kinlough 9.40, Manorhamilton 10.00, Drumkeerin 10.20, Drumshanbo 10.45, Kiltubrid 11.00.
Ballinamore 9.15, Carrigallen 9.35, Aughavas 9.50, Cloone 10.00, Mohill 10.10, Masonite 10.20, Ck-on-Shannon 10.30, Leitrim 10.40, Kiltubrid 11.00.
Under 14 Hurling school of excellence.
On Saturday last our under 14 hurlers took part in the Veronica Connolly/Mickey Cunniffe inter County hurling blitz hosted by the Padraig Pearses GAA club Roscommon.
The lads played very well, topping their group with wins over selections from Mayo and Roscommon but were very unlucky to lose the final by a goal to Sligo. Congrats to all involved especially Bernard Murray for all his work over the season and also to the Sean OHeslins club for the use of their grounds. | 2019-04-21T06:12:51Z | http://www.leitrimgaa.ie/2008/10/coaching-news-80/ |
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From our home in Chicago, we rode to the beautiful North Branch Trail, up to Chicago Botanic Gardens, and returned south via a lesser known gem, the Green Bay Trail.
I wanna do this! I’ve camped a lot before, but never on a bike. So here’s my first go at it!
My son and I took off for our second bikepacking adventure this year on Illinois’ I&M Canal.
Get That Saw Out Of Your Mouth!
The North Loop Ride. A Chicago Adventure to Remember.
Two state parks, the Hackmatack National Wildlife Refuge ... cabins, camping, or hotel, plus the big city all in one epic weekend bike ride: Enjoy The North Loop Ride — Chicago to Chain O’Lakes State Park. | 2019-04-26T14:41:33Z | https://www.bikeovernights.org/archives/category/u-s-illinois |
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You might know that I'm a total sucker for brightening skin care items, but that's really just an added bonus with Yves Rocher White Botanical Exceptional Hydrating Cream. The day/night cream combo thing didn't really appeal to me initially, as most moisturizers either work well for day and aren't enough for pm, or vice-versa, and are too rich for day but perfect for night. This has the perfect balance of hydration for my skin for night and day. It's not heavy, yet hydrates well and leaves skin feeling instantly softer.
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Biomarkers are invaluable drug development tools to assess and monitor safety in early clinical trials especially when exposure margins are limiting for promising therapeutics. Although progress has been made towards identifying and implementing translational safety biomarkers for a number of organ toxicities such as kidney and liver, significant biomarker gaps still exist to monitor toxicities for testis, pancreas, etc. Several precompetitive consortia [e.g., Predictive Safety Testing Consortia (PSTC), Innovative Medicines Initiative (IMI)] are working with industry, academia, government, patient advocacy groups and foundations with a goal to qualify biomarkers such that they can be used in preclinical studies and clinical trials to accelerate drug development. This manuscript discusses the complexities of novel biomarker discovery, validation and international regulatory qualifications intended for clinical trial applications and shares specific examples from Pfizer Research and Development. As safety biomarkers become widely accepted and qualified by the regulatory agencies, they will increasingly be implemented in early clinical trials, play a key role in decision making and facilitate the progression of promising therapeutics from preclinical through clinical development.
The pharmaceutical industry continues to face challenges in terms of declining productivity. The overall cost of drug development and time for most drugs to reach market has been increasing over the past several decades. From 1975 to 2015, the total expenditures per year for drug discovery and development rose approximately 5-fold while the number of United States Food and Drug Administration (FDA) new drug registrations per year remained relatively flat (Boyer et al., 2016). Substantial resources are being invested in research and development (R&D) across the industry into compounds that eventually fail. The current pharmaceutical R&D process results in only ~10% of the molecules entering phase 1 clinical trials reaching full approval by the FDA (Hay et al., 2014). This high rate of attrition is a key driver in reducing productivity and a significant challenge to the industry. There are a number of explanations for the decrease in productivity including a focus of the industry in areas of unmet medical need and novel biological mechanisms with high risk of failure, a higher entry bar for new drugs due to a competition with enhanced standard of care, higher regulatory hurdles, commercial and financial portfolio decisions and an increase in the complexity and cost of clinical trials (Roberts et al., 2014; Hay et al., 2014); however when a root-cause analysis was completed on 359 phase 3 and 95 new molecular entities and biologic license applications, safety and efficacy were shown to be the two primary causes for compound suspension (Hay et al., 2014).
The standard preclinical testing paradigm has markedly improved drug safety over the past 30 years. In 2000, the results from a multinational pharmaceutical survey and the outcome of an International Life Sciences Institute (ILSI) Workshop were reported and showed that 70% of human toxicity observed during clinical trials is predicted by preclinical studies (Olson et al., 2000). In addition, a 2013 study in Japan reported that 48% of adverse drug reactions observed in clinical trials were predicted by a comprehensive preclinical safety assessment (Ahuja and Sharma, 2014); and in 2017, the IQ Consortium created and utilized an industry-wide nonclinical to clinical translational database to report that animal studies not only have value in predicting human toxicities but also that an absence of toxicity in nonclinical studies predicts a similar outcome in the clinic (Monticello et al., 2017). However, the inability to predict failures before or early in clinical trials remains a main cause of attrition (Ahuja and Sharma, 2014) as failures in clinical safety not predicted in preclinical studies continue to be a major cause of compound termination (Clark and Steger-Hartmann, 2018). In addition, clinical failures due to toxicity are not limited to the early clinical portfolio but are also evident in late stage development and post-marketing surveillance (Waring et al., 2015). Thus while preclinical data has had a significant impact on improving clinical drug safety, failures due to toxicity remain a key challenge facing the industry.
The high rate of attrition and cost of drug development has prompted a surge in research in the area of biomarkers. According to the FDA/National Institute of Health (NIH)’s BEST (Biomarkers, Endpoints, and other Tools Resource) guide, a biomarker is a ‘defined characteristic that is measured as an indicator of normal biologic processes, pathogenic processes, or responses to an exposure or intervention, including therapeutic interventions (FDA, 2016a).’ Biomarkers are invaluable drug development tools utilized to better understand the translatability of preclinical findings into human adverse events and to better assess and monitor these findings in the clinic especially when exposure margins are limiting for promising therapeutics. Although progress has been made towards identifying and implementing translational safety biomarkers for a number of organ toxicities such as kidney and liver, significant biomarker gaps still exist. Several precompetitive consortia (e.g., PSTC, IMI) are working with industry, academia, government, patient advocacy groups and foundations with a goal to qualify biomarkers such that they can be implemented in preclinical studies and clinical trials to accelerate drug development. This paper discusses the complexities of discovering, validating and qualifying novel biomarkers to understand organ toxicities and to accelerate drug development decisions. Specific biomarker case examples are highlighted to describe their implementation in preclinical and early clinical development to characterize safety issues, understand mechanisms and monitor clinical safety. As safety biomarker assays are validated and qualified by the regulatory agencies, they will increasingly play a key role in decision making and facilitate the progression of promising therapeutics from preclinical through clinical development. This, however, is not a trivial endeavor and the path to success may best be achieved through a collaborative effort among industry, academia and regulatory partners.
In 2004, the FDA’s Critical Path Initiative emphasized the need for innovation in drug development and suggested the use of biomarkers to evaluate and predict safety and effectiveness, provide informative links between mechanism of action and clinical utility, understand the translatability between preclinical species and humans, and serve as surrogate endpoints. With a focus on generating and implementing translatable biomarkers early in the drug development process, the goal was for the pharmaceutical industry to improve the high attrition rates and process inefficiencies in terms of cost and time observed across the industry (Haim, 2011; Woodcock and Woosley, 2008). In drug development, biomarkers categorized as target biomarkers assess the ability of the drug to reach and engage the target while mechanism biomarkers test the ability of the drug to induce the expected measurable molecular or cellular pharmacodynamics response. Finally, the linkage of the mechanism to the clinical response or efficacy is assessed by disease biomarkers or clinical activity scores. Ideally, safety biomarkers inform the presence or extent of toxicity and thus increase confidence in safety and the ability to predict, detect and monitor the progression of drug-induced toxicity. The ability of safety biomarkers to detect early toxicity, monitor onset and reversibility, and manage adverse effects observed in the clinic will determine its overall utility and impact in preclinical and clinical drug development. With the emergence of innovative technologies and a diverse set of in vitro and in vivo models, the development of novel safety biomarkers has evolved to include not only the singular measurement of circulating proteins but also expression profile signatures in blood/tissue, noninvasive imaging and genetic variations in DNA (Currid and Gallagher, 2008). Assays for these biomarkers range from exploratory fit for purpose to fully validated and qualified by the regulators for a specific context of use and the process of assay validation should be regarded as being continuous and evolving over-time. Pfizer has a strong commitment to developing and implementing translatable biomarker strategies within drug development including applying protein biomarkers for drug-induced toxicity in the stomach, kidney, skeletal muscle and liver and small molecules/metabolites as biomarkers for drug-induced toxicity to the liver and heart. Several biomarker case examples from Pfizer R&D efforts are included in this review. All procedures performed on animals used in Pfizer examples were in accordance with regulations and established guidelines and were reviewed and approved by an Institutional Animal Care and Use Committee.
A number of emerging urinary kidney markers including kidney injury molecule 1 (KIM-1), clusterin, microalbumin, trefoil factor 3, α-glutathione S-transferase, N-acetyl-β- D-glucosaminidase (NAG), neutrophil gelatinase-associated protein (NGAL) and osteopontin are currently being evaluated across the industry. Published studies of emerging markers show promising results in terms of increased sensitivity and specificity in comparison to the standard serum markers, serum creatinine (sCr) and blood urea nitrogen (BUN) (Chen et al., 2017; Dieterle et al., 2010a; Fuchs and Hewitt, 2011; Ozer et al., 2010; Koyner et al., 2010). Although sCr and BUN continue to be utilized as primary renal markers in clinical practice, they are considered poor indicators of early renal dysfunction due to limited sensitivity, remaining relatively unchanged until significant renal damage occurs. Consequently, further evaluation of novel urinary biomarkers of acute kidney injury (AKI) is warranted both in preclinical species and in humans. In order to better understand the performance of KIM-1, NGAL, and NAG in the rat and to provide foundational information for potential clinical studies, a rat study was conducted to compare the performance of these urinary biomarkers to the standard serum markers of AKI for the detection of nephrotoxicity (Burt et al., 2014). These 3 markers were selected after a prescreening of a larger panel based on performance after administration of polymyxin B, a polypeptide antibiotic used for the treatment of life-threatening Gram-negative bacterial infections. Use of these antibiotics in the clinic has been drastically limited due to drug-induced AKI and thus the further development of more-sensitive renal markers has the potential to not only impact drug development but also patient care in the clinic. In this study, rats (5/group) were dosed with 0.1, 0.4, 1, 4 or 10 mg/kg polymyxin B for 2 or 14 days and then necropsied. The highest tolerated dose was 4 mg/kg. Histopathological examination of kidneys from the treated rats showed minimal chronic progressive nephropathy (CPN) in a single rat at the 3 lowest doses, minimal to moderate tubular degeneration/regeneration in 4 animals dosed at 4 mg/kg/day and minimal tubular necrosis in a single rat at 10/mg/kg/day, indicative of drug-induced kidney injury. Of the biomarkers tested, only NGAL and KIM-1 produced dose-dependent statistically significant elevations, 13-fold and 3-fold respectively, as early as 48 hr post-dose. In comparison, sCr was not affected by polymyxin treatment and increases in BUN were small (1.3-fold) and were not dose-dependent. Urinary NGAL, however, was the most sensitive biomarker of AKI in this rat model, responding to the early onset of kidney injury observed with polymyxin. Since urinary NGAL levels reached a maximum increase at 48 hr post-dose (Fig. 1) that correlated with kidney histopathology, a 2-day study design was implemented for screening and rank ordering potential drug candidates utilizing NGAL as the biomarker for AKI. This design provided an important tool for selecting novel polymyxin B analogs with an improved kidney safety profile, affording an efficient, cost-effective drug development biomarker-driven strategy. This work also provided a basis for potential clinical studies to further evaluate the diagnostic utility of these urinary kidney biomarkers in patients (Burt et al., 2014).
NGAL response in rats to polymyxin B treatment. Urine was collected at intervals throughout the study with dosing on Day 0. Group mean values from the treated group were compared with the mean of the saline control group (* p < 0.05; ** p < 0.01).
Spontaneous histologic changes in laboratory animal species including rabbits can hamper accurate toxicologic interpretation in preclinical safety studies, especially if detailed study procedures are included. As early as 1924, publications described inflammatory heart findings with multifocal myocardial infiltrates of lymphocytes and/or macrophages in otherwise healthy rabbits (Sellers et al., 2017). In order to better characterize these myocardial findings and further understand the impact of study-related procedures on these findings, a large study was designed in New Zealand White female rabbits with either an increase (Group 1) or decrease (Group 2) in the number of study-related procedures and animal handling. Blood was collected for coagulation, hematology and clinical chemistry analysis including stress-associated serum biomarkers (epinephrine, norepinephrine, cortisol, and corticosterone) at various time points throughout the study for Group 1 and only at baseline and necropsy for Group 2 to minimize handling and procedures (Sellers et al., 2017). Group 1 animals with the increased procedures had a higher incidence of inflammation with degeneration/necrosis in cardiac myocytes than the animals from the minimal procedure group (Group 2). Serum stress markers including cortisol and norepinephrine showed the greatest response in Group 1 animals with peak values usually occurring 4 hr and 48 hr post-dose respectively (Fig. 2). This study provided further evidence that increased procedures and handling during study conduct exacerbates the frequency and severity of myocardial inflammatory findings and may be mediated by a stress response. Based on these findings, it was proposed that stress hormones, in particular norepinephrine and cortisol, could be utilized to assess the risk of the myocardial findings observed in rabbit toxicology studies (Sellers et al., 2017).
Norepinephrine and Cortisol levels in rabbits following dosing with saline on Days 29, 43 and 57 with blood collections pre-dose (vertical lines) and at 4, 24 and 48 hr post-dose. Data represents group means ± SEM.
Hyaluronic Acid (HA) is a polysaccharide located in the extracellular matrix. It is synthesized by mesenchymal cells and cleared almost exclusively by liver sinusoidal endothelial cells (SECs). Circulating HA levels have been shown to be elevated with structural and/or functional damage to the liver SEC and have shown promise in the clinic when studied for the noninvasive detection of sinusoidal obstruction syndrome (SOS). Currently the diagnosis of SOS in the clinic relies on nonspecific clinical and laboratory measures and/or events occurring late in the development of the disease including jaundice, painful hepatomegaly, weight gain and ascites. SOS has been reported in patients treated with antibody-calicheamicin conjugates including gemtuzumab ozogamicin and inotuzumab developed for acute myeloid leukemia and acute lymphoblastic leukemia, respectively (Guffroy et al., 2017). Liver toxicity based on elevated aspartate aminotransferases (AST) and bilirubin levels was observed with occasional hepatic SOS following treatment with these antibody-drug conjugates (ADCs). While these two ADCs have different monoclonal antibodies, they are composed of the same linker and calicheamicin payload. To further evaluate the mechanism of the adverse event and to identify potential safety biomarker to detect the damage throughout the disease course, an experiment was initiated to characterize the liver injury observed with the ADCs. Cynomologous monkeys were dosed with an antibody-calicheamicin conjugate containing the same linker-payload as gemtuzumab ozogamicin and inotuzumab. Monkeys were dosed with up to 3 intravenous bolus injections 3 weeks apart and were necropsied 48 hr following the first dose on day 3 and 3 weeks after the third administration on day 63. Liver histopathology showed midzonal degeneration and loss of SECs on day 3 and variable endothelial recovery and progression to a combination of sinusoidal capillarization and sinusoidal dilation/hepatocellular atrophy, consistent with early SOS. Minimal increases in AST levels (up to 3.1x) were observed on day 4 and remained elevated over the duration of the study. HA levels (up to 8.5x) were elevated on day 3 and were sustained thru day 63 in all treated monkeys (Fig. 3) demonstrating the ability of this marker to detect early structural damage (day 3) and later functional impairment (day 63) of SECs. HA also showed good correlation to AST levels and microscopic liver findings throughout the study. Since HA, unlike AST, is linked mechanistically to SOS, it was proposed as a sensitive exploratory diagnostic marker of liver microvascular injury capable of non-invasive detection of SOS in the clinic (Guffroy et al., 2017).
Hyaluronic Acid (HA) and Aspartate Aminotransferase (AST) levels in monkeys following dosing (vertical lines) with an antibody-calicheamicin conjugate and linker. Data represents group means. Statistically significant changes were observed for both HA and AST when compared to vehicle controls at all time points following dosing.
Gastrin is secreted from the stomach and plays a key role in the regulation of gastric acid secretion. Gastrin is synthesized in special endocrine cells (G cells) primarily in the antral region of the gastric mucosa and binds receptors found predominantly on parietal cells stimulating gastric juice secretion, the best-known of which is hydrochloric acid (HCl) (Henderson, 2001). The capacity of the stomach to secrete HCl normally is directly proportional to the parietal cell number. High levels of circulating gastrin can occur when the pH of the stomach is high while gastrin secretion by antral G cells is inhibited by the direct action of acid on the G cells. When the stomach lining is damaged and unable to produce and release acid, gastrin continues to be secreted from the fundus and circulating levels rise. Changes in serum gastrin have been shown to be predictive of the functional status of the antral mucosa, making it attractive as a potential biomarker of drug-induced stomach toxicity (Graham et al., 2006; Nicolaou et al., 2014). To further evaluate gastrin as a potential marker of stomach toxicity, a 28-day dog study was conducted with a compound associated with gastric effects. Minimal to moderate atrophy and minimal degeneration of the fundic mucosa were seen at histologic examinations. Mean serum gastrin levels in the treated animals were 23x higher than concurrent controls (Fig. 4) and were attributed to the lack of acid production by the damaged parietal cells, indicating a failure of the feedback mechanism that controls the acid output in the stomach. In individual dogs, serum gastrin levels were elevated (up to 52x) compared to concurrent controls and these levels correlated with the severity of the adverse microscopic stomach findings. Based on these data, serum gastrin was proposed as a non-invasive stomach-specific biomarker to monitor for stomach toxicity in the clinic.
Gastrin concentrations in a 28 Day Dog Study following treatment with vehicle or a compound associated with gastric effects. Data represents group means ± SD.
Many of the safety biomarkers currently considered conventional and measured routinely in both preclinical and clinical drug development as well as in clinical practice were established prior to the implementation of a formal regulatory qualification process. They were accepted based on scientific community consensus, i.e. review of datasets published in peer reviewed journals, experience in clinical practice, and recommendations from professional medical associations. For example, cardiac troponin (cTn) was recognized as a clinical biomarker of acute myocardial infarction by the American College of Cardiology and the European Society of Cardiology in 2000 (Jaffe, 2001) just thirteen years after the development of the first troponin assay (Danese and Montagnana, 2016). Diagnostic criteria were recommended based on published literature and clinical experience with an acknowledgement that the criteria should continue to evolve as additional knowledge was gained (Jaffe, 2001). Subsequent to clinical acceptance, cTn was evaluated as a preclinical marker by the Health and Environmental Sciences Institute (HESI) Cardiac Troponins Biomarker Working Group (Reagan, 2010) and received full qualification from the FDA in 2012 based solely on evidence from peer reviewed scientific literature (FDA, 2012).
Another pathway to biomarker approval is through biomarker evaluation for a drug-specific application. In this case, the biomarker may only be used in a single drug development program and the data required to support the use of the biomarker in the program is determined by the sponsor communicating directly with the regulatory reviewing division accountable for the program (Mattes and Goodsaid, 2018). Utilization of this pathway limits the knowledge of the biomarker’s performance and intended use for the specified program but may enable time saving and efficient progression of a promising compound into clinical development.
In order for a biomarker to be approved for multiple drug development programs, it must pass the rigor of the full regulatory qualification process. Qualification is defined by the FDA as ‘a conclusion that within the stated context of use, the results of assessment with a drug development tool (biomarker) can be relied upon to have a specific interpretation and application in drug development and regulatory review (FDA, 2014).’ Biomarkers reaching this milestone can support regulatory decisions in drug development programs for the approved context of use (COU) in clinical trials. According to the FDA, the COU is ‘a comprehensive and clear statement that describes the manner of use, interpretation, and purpose of use of the biomarker in drug development (FDA, 2016b).’ With the enactment of the 21st Century Cures Act in December 2016, an updated multi-stage biomarker qualification process was established which included three submission stages: the Letter of Intent, the Qualification Plan and the Full Qualification Package. The Biomarker Qualification Program is one of the Drug Development Tools created by the Center of Drug Evaluation and Research to provide a framework for development and regulatory acceptance of biomarkers for use in drug development programs. Similar programs outlining processes for the submission and review of data supporting the approval of new biomarkers are also in place at the European Medicines Agency (EMA) and the Japanese Pharmaceutical and Medical Devices Agency (PDMA). While the agencies work closely on qualification efforts, a fully harmonized approach has yet to be established. However, these regulatory pathways provide a process to review, evaluate and adopt new tools into regulatory decision making in drug development and facilitate consensus science and acceptance of the biomarker’s proposed COU in drug development (Dennis et al., 2013).
To better understand the elements of biomarker qualification, a framework for evidentiary standards for biomarker qualification was recently proposed under the auspices of the Foundation for the National Institute of Health (FNIH) Biomarkers Consortium with representatives from FDA, NIH, industry, patient groups and academia. Five components were incorporated into the framework and included: 1) defining a statement of need (knowledge gap or drug development need) that the biomarker intends to address; 2) defining the COU; 3) assessing the benefits in light of the COU; 4) assessing the risks with regards to the COU and 5) defining the evidentiary criteria required to support the COU (Leptak et al., 2017). The COU determines the level of evidence needed both for the validation of analytical technology employed and for the qualification of the biomarker. The greater the risk to human health of an incorrect decision based on the use of the biomarker, the greater the level of evidence required for the qualifying the biomarker for that COU (Dennis et al., 2013). The assessment of the evidentiary criteria is intended to be utilized as a ‘communication tool for gaining alignment between submitters and FDA reviewers at several key milestones for a biomarker development plan: (i) initial discussions to align expectations; (ii) purposeful interim progress updates to ensure that evidence expectations have been met before proceeding further; and (iii) review evaluation to support the qualification outcome (Leptak et al., 2017).’ The ultimate goal of this effort was to improve the quality of submissions to the FDA, facilitate a level of predictability in the qualification process, and provide clarity as to the type and level of evidence needed to support a biomarker’s COU (Leptak et al., 2017).
Due to the complexity of the qualification process and considerable resources required to reach full qualification of a biomarker, efforts are primarily focused in consortia such the HESI, the PSTC, the IMI Safer and Faster Evidence-based Translation (SAFE-T) consortium and more recently the IMI Translational Safety Biomarker Pipeline (TransBioLine) consortium. To date, 4 safety biomarker submissions have been successful. This included 2 preclinical qualifications for a number of emerging urinary nephrotoxicity biomarkers and one nonclinical qualification of circulating cardiac troponins as indicators of cardiotoxicity. Earlier this year, the first clinical safety biomarker submission reached approval for a panel of urinary biomarkers to aid in the detection of kidney tubular injury in phase 1 trials in healthy volunteers (FDA, 2018b).
GLDH has been shown to be a sensitive measure of hepatotoxicity in preclinical species and in humans (Giffen et al., 2003; Schomaker et al., 2013) and is currently going through the regulatory qualification process sponsored by the PSTC and the Duchenne Regulatory Science Consortia (D-RSC). The gold standard biomarker for the diagnosis of liver injury is alanine aminotransferase (ALT). However since ALT is also present in myocytes, serum ALT activities can increase with muscle injury; thus, the development of more specific biomarkers for drug-induced liver injury (DILI) is needed. For this qualification, the proposed COU for GLDH is that ‘elevated serum GLDH activity is a measure of hepatocellular injury, and can be used in healthy subjects and patients as an adjunct to ALT, the current standard biomarker used to assess hepatocellular injury, in all stages of drug development. In a clinical situation when ALT increases are observed, GLDH can lend weight of evidence to confirm or rule out hepatocellular injury (EMA, 2017).’ The qualification submission will include a full technical validation of the assay and an evaluation of the clinical relevance of the biomarker, e.g., added value relative to aminotransferase activity, correlation to histopathology in a preclinical species and exploratory and confirmatory analyses in clinical subjects with regulatory guidance. The evaluation of clinical relevance includes establishing reference ranges for healthy subjects and evaluating the influence of gender and age, confirming GLDH as a sensitive biomarker of liver injury and establishing medically relevant cutoffs for DILI, and establishing GLDH as a specific biomarker of hepatocellular injury in comparison to ALT. In March of 2017, a joint FDA and EMA biomarker qualification consultation meeting was held for GLDH. This meeting provided regulatory support for using organ injury induced by diseases with a wide range of etiologies as approximation of chemical-induced organ injury for evaluation of performance of novel biomarkers. This was a paradigm shift in the development of safety biomarkers, since it eliminates the need for lengthy clinical trials and improves feasibility and efficiency of biomarker research. The EMA issued a Letter of Support (LoS) in November 2017 demonstrating the Agency’s support of the qualification and provided additional feedback regarding data needed for achieving full qualification of GDLH as a “Drug Development Tool”. This LoS not only recognized the potential value of GLDH as a liver specific biomarker of hepatocellular injury to address important unmet medical need but also endorsed data interpretation including medically relevant levels of GLDH (2.5x and 5x above upper limit of normal) that were established as part of the qualification effort (EMA, 2017). This qualification effort, initiated in 2015 supported by Pfizer internal exploratory data, is expected to reach fruition in 2019 with the submission of the full qualification package. The formal qualification of GLDH as a liver specific biomarker of hepatocellular injury will not only allow for the broad application of GLDH across programs, but will also enable the diagnosis of the onset of liver disease in subjects with underlying muscle impairments, which is an important unmet medical need widely recognized by the medical community. To this end, Pfizer has partnered with the PSTC, the Duchenne Regulatory Science Consortium (D-RSC), Roche, the maker of the research grade GLDH assay, and FDA to validate the GLDH assay as an in vitro diagnostic (IVD) which would allow the assay to be utilized in clinical practice and lead to an improved standard of care for patients living with muscle disease.
Serum AST and creatine kinase (CK) have been used for decades as the primary biomarkers for skeletal muscle (SKM) injury as a measure of myocyte degeneration/necrosis. However, these markers lack tissue specificity for SKM and sensitivity for SKM degeneration/necrosis in both rats and humans. In 2010, the PSTC’s Skeletal Muscle Working Group was formed with a goal to identify and qualify novel safety biomarkers of drug-induced SKM injury that would add value to the current markers, CK and AST, for monitoring SKM injury. The muscle injury panel (MIP) selected for evaluation included skeletal troponin I, myosin light chain, fatty acid-binding protein and creatine kinase measured by a mass assay. These markers were assessed in 34 rat studies and were shown to outperform AST and CK (enzymatic assay) individually and as a panel in terms of sensitivity and specificity and/or added value for the diagnosis of drug-induced SKM injury defined as myocyte degeneration/necrosis (Burch et al., 2016). Based on this data, the FDA and EMA issued Letters of Support (EMA, 2015; FDA, 2015) for the use of these markers in preclinical development and encouraged their use in early clinical trials in an exploratory context. This endorsement encouraged Burch et al. (Burch et al., 2015) to evaluate the translatability of these markers in patients with DMD and other muscular diseases and their ability to monitor disease progression and the response to treatment. In this study, the MIP biomarker responses was compared to current clinical assessments including CK activity, ambulatory status and cardiac function and were shown to not only better reflect the patients’ disease state compared to CK activity but also correlate with clinical endpoints in patients with DMD and other muscular diseases. These preclinical and clinical evaluations provided support for a qualification submission which is currently in progress. This qualification, sponsored by the PSTC, will evaluate the marker’s ability to monitor SKM degeneration/necrosis in conjunction with AST and CK enzymatic activity in early clinical trials and encourage the utilization of the MIP markers throughout drug development to improve patient safety in clinical trials (Burch et al., 2016). In support of the qualification effort, Pfizer has included the MIP markers on a number of clinical trials as exploratory biomarkers; however, the utility of the markers as SKM safety or efficacy end points to these therapeutic interventions has yet to be determined (Goldstein, 2017).
In 2008 the first formal qualification of preclinical safety biomarkers was granted by the FDA (FDA, 2008) and EMA (EMA, 2008a) followed by PMDA in 2010 (PMDA, 2010) for seven urinary safety biomarkers submitted by the PSTC. In 2010, a qualification was rendered by the FDA for the two preclinical urinary biomarkers, clusterin, renal papillary antigen-1 (RPA-1), submitted by HESI and in 2018 the FDA qualified the first clinical safety biomarkers, a set of six urinary markers interpreted as a Composite Measure (CM) (FDA, 2018a) submitted by PSTC. In all cases, the biomarkers are to be used in conjunction with the traditional measures, serum creatinine (sCr) and blood nitrogen urea (BUN), for the evaluation of nephrotoxicity. sCr and BUN are both insensitive and nonspecific, changing only after significant injury and with a time delay relative to the onset of injury (Vaidya et al., 2008) limiting their ability to accurately estimate injury onset and the severity of the dysfunction following injury (Ferguson et al., 2008).
The seven biomarkers included in the PSTC preclinical submission included KIM-1, clusterin (CLU), albumin, total protein, β2-microglobulin, cystatin C and trefoil factor 3 (TFF3) in urine. The submission contained data and data interpretation from a number of rat studies, a review of the scientific literature in humans (KIM-1, albumin, total protein, cystatin C, and β2-microglobulin), COUs for each biomarker (Dieterle et al., 2010b) and key conclusions. The PSTC put forth three specific biomarker claims in the submission. First, urinary KIM-1, CLU, and albumin can individually outperform and add information to BUN and sCr assays as early diagnostic biomarkers of drug-induced kidney tubular alterations in rat toxicology studies. Second, urinary TFF3 can add information to BUN and sCr assays in rat toxicology studies as an early diagnostic biomarker of drug-induced acute kidney injury tubular alterations. Third, total urinary protein, cystatin C, and β2-microglobulin can individually outperform sCr assays and add information to BUN and sCr assays as early diagnostic biomarkers in rat toxicology studies of acute drug-induced glomerular alterations or damage resulting in impairment of kidney tubular reabsorption (Dieterle et al., 2010b). In addition, the PSTC claimed that this rat data taken together with the published peer-reviewed clinical data supported the voluntary use of KIM-1, albumin, total protein, cystatin C, and β2-microglobulin as bridging markers for early clinical trials on a case-by-case basis when concerns are generated in GLP animal toxicology studies. During the qualification effort, the FDA and EMA provided feedback regarding submission gaps, statistical considerations and preliminary conclusion statements (EMA, 2008b) which culminated in letters of acceptance for the preclinical qualifications from both agencies. In 2008, the FDA and EMA concluded that the urinary kidney biomarkers KIM-1, CLU, albumin, total protein, β2-microglobulin, cystatin C and TFF3 were acceptable for the detection of acute drug-induced kidney injury in rats to be included along with traditional clinical chemistry markers and histopathology in toxicology studies. The EMA also stated that while it was worthwhile exploring their utility in early clinical trials as clinical biomarkers, until additional data was available “to correlate the biomarkers with the evolution of the nephrotoxic alternations, and their reversibility, their general use for monitoring nephrotoxicity in clinical setting cannot be recommended (EMA, 2008b).” Based on this data, in 2010 the PDMA announced the first biomarker qualification decision under the new consultation process on pharmacogenomics/biomarkers use in Japan. These recommendations, consistent with the concept of a progressive biomarker qualification, prompted the generation and submission of additional preclinical and clinical data to expand the COU.
In an expanded effort, the SAFE-T and PSTC consortia continued the work on urinary kidney injury biomarkers by evaluating the performance of KIM-1, CLU, NGAL, albumin, total protein, cystatin C, α -glutatione S-transferase and urinary osteopontin in clinical trials. The trials included a study in healthy volunteers, an exploratory study with cisplatin-treated cancer patients, and a study in patients undergoing coronary angiography. The markers selected are localized in different regions of the nephron thus the panel was expected to respond to a variety of nephrotoxicants. Based on the readout from these studies, both the FDA and EMA issued Letters of Support in 2016 encouraging the exploratory use of these markers as biomarkers of renal tubular injury in early clinical trials to be used in conjunction with traditional biomarkers and clinical and nonclinical findings (FDA, 2016c; EMA, 2016).
Also in 2016, the FNIH Biomarker Consortium and the PSTC submitted a qualification submission for a kidney injury biomarker panel to be interpreted as a Composite Measure (the geometric mean of the fold change from baseline of the six urine biomarkers normalized to urine creatinine) of the following six biomarkers: KIM-1, CLU, cystatin C, NAG, NGAL and urinary osteopontin. According to the COU, “the safety composite biomarker panel is to be used in conjunction with traditional measures to aid in the detection of kidney tubular injury in phase 1 trials in healthy volunteers when there is an a priori concern that a drug may cause renal tubular injury in humans (FDA, 2018a).” The qualification strategy included a nonclinical phase, a clinical exploratory phase and a clinical confirmatory phase with a cisplatin study in cancer patients and an aminoglycoside study in cystic fibrosis patients. Based on this data, this panel, interpreted as a CM, was the first clinical safety biomarker to be qualified by the FDA. Following on the success of this qualification, the FNIH and PSTC have continued their partnership and have submitted a letter of intent to FDA, EMA and PDMA to further qualify the panel of biomarkers based on the individual biomarker response thus expanding on the qualified CM COU.
Significant progress has been made towards implementing translational safety biomarker strategies into the drug development portfolio. Several pharmaceutical companies have been adopting exploratory biomarkers in their preclinical and clinical drug development programs and contributing to consortia led qualification efforts. While much progress has been made towards the qualification of biomarkers for some organ injures including liver, kidney, and muscle, significant gaps remain for other target organs such as biomarkers of vascular injury in humans, sensitive biomarkers of pancreatic injury, circulating biomarkers of testicular toxicity, and biomarkers of injury to the central nervous system. Because the process of biomarker development is complex and requires considerable resources (Gerlach et al., 2018), these efforts will best be pursued by consortia such as PSTC and IMI. Prior to widespread acceptance, each biomarker must undergo a rigorous assay validation; demonstrate relevance to humans and an association with clinical endpoints reproducibly in multiple studies and gain consensus regarding the level of evidence needed to support a qualification for the stated COU. Due to the complexity and feasibility challenges of prospective randomized drug intervention clinical trials, alternative sample collection strategies like the prospective collection of samples of organ damage etiologies from patients undergoing hospital visits employed in the GLDH qualification effort, need to be considered. These disease patient populations, once identified, can serve as surrogates for drug-induced organ injury to evaluate biomarker performance as long as common molecular and mechanistic pathways are shared between the disease and organ toxicity of interest. The prospective collection and storage of samples from clinical trials conducted for drug development is also an option (Aubrecht et al., 2013). As safety biomarkers become accepted and qualified by the regulatory agencies, they will increasingly play a key role in decision making and facilitate the progression of promising therapeutics from preclinical through clinical development, leading to the realization of our most critical goal: delivering the right dose of the right medicines to the right patients at the right time (Gerlach et al., 2018).
Safety and tolerability of newly approved drug candidates still remains a key concern in drug development leading to black box warnings and withdrawals of promising therapeutics. A major hurdle is the lack of validated and qualified safety biomarkers that accurately diagnose, predict and inform mechanism of organ toxicities. Regulatory qualification of a safety biomarker is critical for routine application in clinical development. To address this hurdle and the complexities in biomarker development, considerable resources and partnerships across industry, academia, and regulators is needed. Although tremendous progress has been made towards identifying and implementing translational safety biomarkers for organ toxicities such as kidney and liver, significant gaps still exist to monitor toxicities for other common target organs such as pancreas, central nervous system, testis, and skeletal muscle. With the enactment of 21st Century Cures Act, the FDA biomarker qualification process has become more streamlined. In addition to developing a clear frame work for regulatory qualification, there is optimism towards expediting the qualification process so that promising therapeutics can be safely tested in the clinic and ultimately provide patients access to new medicines.
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Woodcock, J. and Woosley, R. (2008): The FDA critical path initiative and its influence on new drug development. Annu. Rev. Med., 59, 1-12. | 2019-04-21T04:51:20Z | https://www.jstage.jst.go.jp/article/jts/44/4/44_225/_html/-char/en |
Is digital transformation the must win battle for pharma’s ? Or should it rather focus first on customers/patients experience acquisition?
After decades of product development, we see that current pharma companies are facing more and more difficulties to deliver high value innovation in a more and more costs containment environment. Era of Blockbusters, promoted by large scale pushed promotion models, addressing large patients’ volumes, has ended in the famous patent cliff. Pharma’s are now facing new challenges in their promotional and interaction models: (1)Patients became real empowered consumers; (2) HCP’s new generation are less confident with Pharma’s information streams and do prefer neutral and on demand ones and (3) There is an increasing pressure on Pharma promotion model. On top of those trends, Pharma’s have to deal with new powerful actors as GAFAs in health area. Digital giants are gaining sustainable space in interactions with patients and HCPs. Situation is serious: After “the patent cliff period” Pharma is just about to face a “customer cliff”, according to Franck Lemeur. In his talks, Franck will explain us that, before addressing classical digital transformation or developing any other multichannel programs, Pharma needs to understand what the best ways and levers are to reshape interaction model with HCPs and Patient. Pharma should install “Customer centricity first” as a drive in any promotional model initiative and it must become the priority before any digital or other multichannel program.
Doctor in Pharmacy and graduated from HEC Marketing Intelligence Master, Frank Lemeur has been working in the pharmaceutical industry for 24 years. He has had multiple operational and strategic experiences as Marketing Director, Business Excellence Director, Business Units Director, Strategy Director, etc.
Frank participated to the success of major launches, including Aprovel, Inipomp, Xatral, Acomplia and Zentiva Generics.
In 2011, he started Sanofi's e-health business in France and completed the Diabeo project.
Most recently, he took responsibilities as Director of Strategic Planning at Sanofi Pasteur Vaccine, as Director of the Global Multichannel Business Sanofi and also became CEO of Chronolife, one of iBionext network’s startups. | 2019-04-24T17:01:38Z | https://www.digimedia.be/forum/pharma/speaker-info.php?id=2183 |
After attending several intensive courses of Tai Ji Quan held by some renowned masters and seeing how commercial it was all and what they were teaching, I said to myself that I can do much better.
This course is addressed to all, especially to beginners or to those who have had the misfortune to learn the commercial version of Tai Ji Quan.
First of all, you should know that Tai Ji Quan does not mean Dao Lu, because the Dao Lu or the sequence of forms is not a way to learn or practice Tai Ji Quan, but only one method of training without a partner for those who are already advanced in Tai Ji Quan, and not for beginners.
It will include basic techniques you can not practice Tai Ji Quan without, namely the basic position of Tai Ji Quan, Zhuan Kua or the hip rotation, Yao Dong or the movement of the spinal column, Yuan Shou or the Cloud-Hands form, Bu Fa or stepping technique, and the breathing technique in Tai Ji Quan - the reverse breathing. These techniques are valid for any style, with small differences.
Tui Shou or pushing-hands is a method of training with a partner, which helps to prepare for real combat.
This course is addressed to advanced practitioners or to those who have already learned some Tai Ji Quan, regardless of style. Those who had the misfortune to learn the commercial version of Tai Ji Quan, may participate, but again will have bad luck: they will not be able to make the applications of the techniques work. So in this case, they must attend the first course, the basic techniques of Tai Ji Quan.
It will include basic techniques of Tui Shou, namely: Yun Shou or cloud-hands ( this time with a partner ), Peng or deviate, Lu or pulling, Chi or pressing, Tui or pushing, Zhuan or twisting, Cai or snatching, Kao or the shoulder strike, Zhou or elbow-strike, including their real applications, and the short Tui Shou Dao Lu with a partner or alone.
If somehow you have learned so far that Tui Shou means to make circles with your hand, you had the misfortune to learn the commercial version of Tai Ji Quan, so somebody took your money and made fun of you.
Attention, both courses include techniques that are usually NOT taught and kept secret, being taught only in the family or to the direct descendants. (Yeah, the bastards are doing this, as I discovered it myself, and also others as well).
Each course will be 10 hours-long, distributed in a single weekend, and will take place only if a minimum of 5 people will enroll.
Usually the courses will be held in Bucharest, or in any other city in Romania, if a sufficient number of people will gather.
The courses can be held in any city in Europe, only if a sufficient number of people will gather, enough to cover travel expenses.
Please feel free to point any grammar mistakes, English is not my native language. | 2019-04-19T07:29:35Z | http://artemartialeinterne.blogspot.com/2013/12/tai-ji-quan-intensive-courses.html |
Review: Feuding Fan Dancers | Oh, The Glamourous Life!
Feuding Fan Dancers: Faith Bacon, Sally Rand, and the Golden Age of the Showgirl by Leslie Zemeckis (2018).
If you are interested in the full story of Sally Rand, read “Barefoot to the Chin – the FANtastic life of Sally Rand” published in August 2018 and available at Amazon. The book is over 800 pages (with 100 images) and tells the story of this amazing woman in all its wonder, warts and all. Researched and written over a period of more than 8 years, it is largely based on exclusive access to Miss Rand’s personal files and scrapbooks. | 2019-04-21T12:51:34Z | https://missminamurray.wordpress.com/2018/12/05/review-feuding-fan-dancers/ |
Look up volte-face in Wiktionary, the free dictionary.
Volte-face (/vɒltˈfɑːs/ or /voʊltˈfɑːs/) is a total change of position, as in policy or opinion; an about-face.
The expression comes through French, from Italian voltafaccia and Portuguese volte face, composed of volta (turn) and faccia (face).
In the context of politics a volte-face is, in modern English, often referred to as a U-turn or a flip-flop in the UK and the US respectively.
The royal assent by Charles I in June 1628 to the Petition of Right.
The 1938 decision of British Prime Minister Neville Chamberlain to subsidize Balkan economies to resist German economic supremacy.
The successful manoeuver of Italy in September 1943, when the Italian Army capitulated immediately after the Allied invasion of Sicily. Italy switched sides from one of the aggressor Axis Powers and was allowed to co-operate with the Allies with notable benefits (Britannica: "The Allies' invasion of Italy and the Italian volte-face, 1943").
The Soviet switch from supporting Somalia to supporting Ethiopia during the Ogaden War.
New Coke replaced Coca-Cola's main product with one containing a different formula. After a public backlash, Coca-Cola reintroduced the original formulation.
↑ Klein, Naomi (2007) The Shock Doctrine: The Rise of Disaster Capitalism. New York: Picador. ISBN 978-0-312-42799-3.
This page was last modified on 9 November 2015, at 15:07. | 2019-04-26T04:32:25Z | https://infogalactic.com/info/Volte-face |
To read ideas and arguments with which I disagree, and to examine and consider such ideas.
To clarify my own views, and work at articulating them.
To have my ideas examined and critiqued. | 2019-04-22T19:55:28Z | http://www.createdebate.com/debate/show/What_do_you_think_305 |
Don't forget about all of the fun happening this week!!
Tomorrow, June 6th is a full day of school. Please note this change from the original school calendar!
Wednesday, June 6th Jerry Palotta comes to JA and we are soooo excited!! Don't forget o ask your child about this exciting event!
Stock up on Gift cards for Summer!! Script order forms went home yesterday!!
Celebrate the Summer Reading season with an evening at Barnes & Noble. Join us on Friday, June 15th from 4pm to 9pm. This is a perfect time to stock up on books, games, and puzzles for those long summer days! The JA Library will directly benefit from all purchases made by Johnny Appleseed families that evening. Local children’s author, Kate Narita will be joining us and reading her new book, 100 Bugs! A Counting Book. She will be reading at 5:00, 6:00 and 7:00. Make sure you preorder if you would like to take home your own signed copy. A beautiful blend of math and science, perfect for a summertime nature hunt!
After today (6/5) only 12.5 days of school till Summer Vacation!! | 2019-04-25T18:48:08Z | http://jaschoolpto.blogspot.com/2018/06/fun-happenings-week-of-6418.html |
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Low Cost with Best Local Shifting with all India – Piyush Packers And Movers in Gandhidham take it as a goal to transport your goods with full safety to your place and provide safe office relocation, iba approved packers movers. Hence, your goods will be delivered on time. However, packers and movers play an main role in the moving process and office relocation. We are known the best for the quality of service and quick response. Besides this, if you want more information you can contact anytime you want. Hence, give us a call right now to book us for your shifting need. | 2019-04-22T19:56:15Z | https://www.piyushpackersandmovers.com/piyush-packers-and-movers-in-gandhidham/ |
Every other Tuesday, 5:30-7:30, beginning January 8, 2019.
Come be part of the Knitterati! Belleville Public Library's social knitting circle "Knitterati" will return in January 2019. Bring your knitting, crochet, or other fiber craft project to this free drop in program on the second floor of the library to work as a group, chat, and meet other knitters! Just starting out and need a little help casting on? Don’t worry; your fellow knitters will be there to give you a hand or offer advice. The program is held every other Tuesday evening from 5:30-7:30 pm, Jan. 8 to Jun. 25 on the 2nd floor. No registration required.
Call 613-968-6731 ext. 2037 for more information. | 2019-04-20T06:32:43Z | https://bellevillelibrary.ca/Calendar/calendar.php?ID=3987&command=view&year=2019&month=03&day=5&LANGCODE=EN |
Incorporating usability testing throughout the entire design process, especially before launch, allows you catch glitches and/or make design changes prior to anyone seeing it live. When more than minor adjustments need to be made to your site, it’s much better to have completed them before the public sees it.
For Christina Mullins, a Contracting Officer at the Public Building Service in the General Services Administration (GSA)’s Region 3 based in Philadelphia, usability testing was a new frontier, and one that quickly proved valuable.
Mullins recently led a project to create an internal agency website called the “GSA Acquisition Portal,” designed to be a “one-stop shop” resource site for GSA’s acquisition workforce, and was asked by a colleague to investigate usability testing.
She connected with Jonathan Rubin, Program Manager for the DigitalGov User Experience Program, and with a little guidance, was able to design a simple but effective test based on completing 12 tasks the project team felt people would want to accomplish with the site.
The website project team consisting of members from various backgrounds and offices in the agency reviewed, prioritized, and finalized the test script. Volunteer testers were recruited from a wide range of positions to represent the breadth of GSA employees who will use the site. The tests were performed on semi-functional pages in a staging environment, completely virtually.
From information architecture and appearance of “buttons” to the order of lists and assumed meanings of words, the testers highlighted many issues they found confusing. As a result, Mullins and her team were able to make crucial adjustments before launch.
Test participants had difficulty finding the FY 2010 Procurement Management Review (PMR) Report, because they did not consider it a “best practice.” Once participants navigated to the “Best Practices” supporting sub-page, they again stated that the links there were not really “best practices.” “Reports & Publications” is a better category description.
During the test, many people scrolled right past the hot buttons, sometimes not noticing them. The design was changed to look more like “buttons” users would think to click on.
Some of the feedback included expanding the Quick Links section to a wider set of activities. Several new links were identified and added. Also, test participants commented that the order of the links was confusing. The order was initially set to follow the acquisition process from solicitation to contract award, but alphabetization is more intuitive.
Mullins also noted the testing served as a motivator for her team.
For more information on usability testing, visit the DigitalGov User Experience Program page or join the DigitalGov User Experience Community of Practice. | 2019-04-24T08:40:34Z | https://digital.gov/2014/04/21/usability-case-study-gsa-acquisition-portal/ |
Social Media advertising is a fundamental gadget for supplying your commercial organization a wholly unique (online social) face. Social Network advertising systems are very exceptional for marketing your ideas on numerous techniques by way of exceptional channels. The sector now has become a bit further socializing globe, as we can evident an entire lot of adjustments passed off within the methods and procedures of promoting in previous couple of years. Social Network advertising through newspapers, tv stays on however there nothing is left in these formulations of promoting as a result of some truth. Now we’ve a way powerful platform of advertising in face of social network advertising strategies.
That may make us in touch with the web world of socialism internationally by means of distinctive channels. Besides all the merchandise of traditional advertising, the Social Network advertising has its very own rank. The sector is more often than not dealing on-line through countless social network pages. They also promote their corporation advertisements to interact the best revenue in brief time. That’s the exceptional and smooth manner of promoting to earn excellent and riskless revenue.
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And the most amazing Google (just about a looking engine for online net) is the most important platform for socializing your online presence all by means of the world!
Read :- How to Increase Twitter Followers – Awesome Tips.
There could also be no doubt about how we will be able to carry buyers or consumers for industrial company as those social websites can provide your enterprise a viral trend.I’m hoping this article helped you to investigate which social network you will have to be specializing in.Recall to subscribe our site by way of RSS FEED right here or you wish to have every put up delivered to your e mail id as it published then please subscribe our website with your e-mail id.You could favorite our internet site by just pressing Ctrl+D & click on add.Share this article on Facebook & Twitter.
Yes, I agree with this article. One of the key components of SMM is social media optimization (SMO). Like search engine optimization (SEO), SMO is a strategy for drawing new and unique visitors to a website. | 2019-04-18T21:02:39Z | https://www.blogmean.org/grow-online-business-via-social-media-marketing/?shared=email&msg=fail |
He pushed himself up, walking as smoothly as he could from the room and into the hall, maneuvering around more injured people and bed, finally making his way out into open hallway. He wasn’t sure where he was at, but a lot of Site-19 looked the same. He just picked a direction and started walking in it.
Once, he was almost certain that he’d heard 106 laughing, but as he turned to look at the empty wall the sound had issued from, it was clean and unmarred.
All evidence from the recovery group that had found Sandlemyer suggested that 106 had somehow gotten itself caught in 015, tangled in the pipes somehow, screaming bloody murder. It would hold the damned thing. Seal it. Maybe eat it like it ate other people. And he'd write up a file. Give it to Gears. Walk away from this. Walk away from this hell that he'd found himself in. And for some reason, knowing that—finally—he had found a way to contain the damned thing was more of a comfort than anything else at the moment.
He looked at the wall again when he thought he heard the laugh a second time. He stepped closer and ran his fingers of it, then stepped back again.
In his head. It was all in his head.
Gears expressionless face betrayed neither pity nor concern. “It was playing with us, Agent. Cat and mouse."
“Utilized?” Lament laughed. Laughing was all he could do, at the moment. He was inches from hysteria. That voice the night before. That mocking laugh as he walked down the hall… Had that been him? Had he been ‘playing’ again? 'Utilized.' It consumed. It devoured.
Gears waited patiently for him to stop. "The men putting the next level of your containment plan in place were attacked and utilized by 106. Three dead on the scene. Four more deceased over the next week from the initial attack. Another twe—"
"Please stop," Lament said, closing his eyes tightly. He leaned against his desk, gripping the top of it tightly, not letting go.
Lament looked up. Gears was right. Lament hadn’t been in for it yet. It had been scheduled for the afternoon of the twenty-seventh, and he’d had other things on his mind that day. This was Foundation compassion, then?
“No, sir, I haven’t,” he answered.
“I’ve scheduled your appointment for this morning,” Gears said emotionlessly.
Lament’s fingers drummed for an instant on his desk, and while he didn’t necessarily want to go, he couldn’t think of any other excuse to get away from Gears for the morning. And getting away from Gears was exactly what he needed at the moment.
“I’m not taking them,” Lament said, staring down the doctor. He'd met with Glass many times in the past. Quarterly psych evaluations, voluntary sessions.
"Lament, you can’t just… ignore this," Glass continued. "These policies and practices were developed by people with far more experience than either of us. Sometimes, you just… need to forget."
“I don’t want to forget.” How many times has the doctor heard that same response?
“Why would you not want to forget watching your friend being devoured by a supernatural… thing?” asked Glass. "You saw him when they got him out. You know he was still alive for a few hours after that, Lament. Why would you want to remember him like that?"
“Because he was my friend.” How many people had he gotten to do this before me?
Glass’s hand tensed on the arm of the chair for a moment, and then relaxed. Lament actually found himself admiring the man when his voice came out even. He'd either not known or had forgotten.
“You were conscripted?” Glass asked.
A moment. “That would have been a Class-A,” said Glass.
“And is there a cure for these things?” Lament asked. He kept his voice conversational, but there was hope there. Hope for parents he couldn't remember and a dozen friends or colleagues he wasn't sure he'd ever had. | 2019-04-22T04:00:59Z | http://www.scp-wiki.net/in-his-own-image-part-6 |
Bringing in an innovative change to counter the cyber crime which has become the greatest challenges of the time and for the first time in the State of J&K, Crime Branch, Jammu succeeded in unearthing the gang of online fraudsters who, day in and day out, used to allure the innocent persons through mobile phone calls by impersonating as officials of IRDA, RBI, SBI, Banks, Insurance companies etc. and collect lacs of rupees through online transactions in different bank accounts provided by them and pertaining to different banks thereby duping the innocent persons of their hard earned money.
For the last 2/3 years number of complaints have been received in Crime Branch, Jammu where the unknown callers had after alluring the complainants taken away their hard earned money through online transactions in different bank accounts, which on verifications turned out to be opened on fake names and addresses.
One such complaint was lodged by Sh. Vijay Kumar Gupta R/o Luxmi Vihar, Kathua wherein it was alleged he had bought Kotak Life Insurance Policy in the year 2009 and had paid its premium till 2012. In 2013 he received a call from one Rahul Aggarwal, who claimed to an agent of Kotak Life Insurance Company and who asked the complainant to deposit an amount of `40,310/- for reviving the policy in the account of Money Back Tour and also provide him copy of his PAN Card, as the policy had lapsed somewhere in 2012. The complaint deposited the amount of `40,310/- in and after some days he was again asked to deposit some more money in different account numbers which were provided by the unknown callers and in the process the complainant deposited `15.00 lacs through nine bank transactions but the money promised to him was not returned. In January, 2015 he again received a call from one Deepak Singhal, who claimed to be an officer of IRDA, who also asked the complainant to deposit more money on account of taxes, lawyer fees etc. and assured him repayment of his money upon which the complainant again deposited an amount of `22,67,650/- through eleven transactions but again his money was not paid and thereafter, realizing the realities of being cheated by these fraudsters he approached the Crime Branch, Jammu.
Faced with such emerging challenges and to cope up with the swelling graph of these frauds Sh. Munir Ahmed Khan, IPS Inspector General of Police, State Crime Branch, J&K immediately directed prioritizing of all such cases and in the process constituted a special team of officers/officials of the Crime Branch, Jammu under the charge of Inspr. Parvez Sajjad, I/c Cyber Cell, Crime Branch, Jammu, who in close coordination with Sh. M. A. Almansoor, Sr.PO, Sh. Rajinder Katoch, Addl. SP and Sh. Mubassir Latifi, SSP Crime Branch, Jammu not only succeeded in tracking the fraudsters in various parts of New Delhi and Noida area after putting in strenuous efforts but also apprehended/arrested seven of them including their masterminds and recovered about `15.00 lacs. Those arrested so far include 1) Chander Shaker Kandpal @ Sharad Kumar R/o Masjid Wali Gali Pink City, Jaipur State Rajisthan, 2) Shiv Kumar @ Raj Kumar Sharma R/o Village Gejhe Noida, Sector-93 Goutambudh Nagar UP, 3) Anil Kumar R/o Julaghat Tehsil Majalkand, Uttrakhand A/P H No.F-04, J-3 Dilshada Colony Delhi 4) Arun Dass @ Deepak Singal @ Goel R/o B-2/351, JJ Colony Madanpur Khadar, New Delhi, 5) Rajeev Tanwar R/o A-128, G-2 Haritvihar Burari, Delhi, 6) Sachin Bhardwaj @ Krishanan R/o A-66, Gali No.2, Ambedkar Vihar, Johripur Delhi and 7) Pushkar Chaudhary @ Baskar R/o H.No.81-C, Pachsheel Enclave Village Basantpur, Haryana.
On preliminary questioning of the arrested persons it has been found that these fraudsters belong to New Delhi, Noida, Bihar, Uttarkhand and Rajasthan area but were working in close coordination with each other. The three kingpins namely 1) Anil Kumar R/o Julaghat Tehsil Majalkand, Uttrakhand A/P H No.F-04, J-3 Dilshada Colony Delhi, 2) Pushkar Chaudhary @ Baskar R/o H.No.81-C, Pachsheel Enclave Village Basantpur, Haryana and 3) Rajeev Tanwar R/o A-128, G-2 Haritvihar Burari, Delhi had opened offices at different locations and had hired/kept different persons as callers to hook up innocent persons/depositors in various parts of the country. These callers used to collect data of various depositors from different banks/insurance companies from their associates and call each and every depositor/subscriber individually by impersonating as officials of Banks/RBI/Insurance companies by collecting the details of the official functionaries from the authorized websites of these banks/insurance companies, in order to provide assurance to the innocent persons and ask for money on different pretexts which was to be deposited in different bank accounts opened in different nationalized as well as private banks on fake names and addresses but operated actually by some of the accused persons and in the process had collected lacs of rupees by duping so many innocent persons throughout the country including the state of J&K.
Some of the account heads/names and numbers which have surfaced are Money Back Club A/c No. 50200008183295 HDFC Bank, New Delhi, Money Back Tour and Travels A/c No. 914020033747174 UTI, Money Back Tour and Travels A/c No. 50200009292694 HDFC Bank, Sharad Kumar Sharma A/c No. 3441851629 CBIN Mayur Vihar Delhi, Sharad Kumar Sharma A/c No. 501000094649410 HDFC Mayur Vihar Delhi, Sharad Kumar Sharma A/c No. 053200101055352 Corporation Bank, Preet Vihar, Delhi, We Care A/c No. 50261229316 Allahbad Bank, We Care A/c No. 083105001047 ICICI Bank, Aegon A/c No. 3427908450 Central Bank of India, Noida, Aegon A/c No. 64168784577 State Bank of Mysore, Noida, Aegon A/c No. 914020057293000 UTI Mayur Vihar, Delhi, A&K Global Solutions A/c No. 50200003707514 HDFC Bank, Noida, Raj Kumar Sharma A/c No.50200008047563 HDFC and Raj Kumar Sharma A/c No.5020000804758 HDFC, Mayur Vihar.
At the instance of these accused persons and their relatives the Crime Branch, Jammu also succeeded in recovering an amount of about `15.00 lacs whereas, rest of the amount is yet to be recovered and arrest of some more persons, connected with the case is likely to be made within due course.
Mubassir Latifi, SSP Crime Branch, Jammu flanked by other senior officers of the Crime Branch, Jammu while addressing the press conference further stated that arrest of these fraudsters is a big success for the Crime Branch, Jammu but many more vital areas are also under investigation as serious issues relating to sharing of personal data pertaining to different account holders and opening of bank accounts on fake names and ID proofs etc. at the behest of some of the Nationalized as well as private banks, Insurance companies etc. has surfaced.
While emphasizing and laying stress on the issue he also appealed to the public at large that “come what may” all such unsolicited calls be avoided abinito and under no circumstances the personal details, account numbers, PIN Codes, ATM Card numbers, Credit card Numbers, CVV codes, Internet Banking passwords etc. be shared with anybody including the so called bank/RBI/SBI/Insurance Company officials, who make calls, as such a step shall ensure safety of their hard earned money and keep them away from the unpleasant hardships. | 2019-04-20T13:21:44Z | http://jknewspoint.com/irda-sbi-imporsonators-caught-by-crime-branch-jammu-rs-15-lacs-recovered/ |
Suffah Primary School is an independent Islamic School based in the London Borough of Hounslow, West London. We are situated on the first floor of Hounslow Jamia Masjid & Islamic Centre.
The school caters for children between the ages of 3 and 11 and has places for 168 full time pupils and 48 part time places in the Nursery. | 2019-04-24T13:56:15Z | http://suffahschool.hounslow.sch.uk/event/year-6-trip-to-old-operating-theatre/ |
In 2009 Saturn Sky was released in 6 different versions, 1 of which are in a body "Convertible".
At the time, according to the manufacturer's recommendations, the cheapest modification 2009 Saturn Sky 2dr Convertible (2.4L 4cyl 5M) with a Manual gearbox should do its future owner of $27595.On the other side - the most expensive modification - 2009 Saturn Sky Red Line Hydro Blue Ltd Ed 2dr Convertible (2.0L 4cyl Turbo 5M) with an Manual transmission and MSRP $33680 manufacturer.
Did you know that: the earliest Saturn Sky, which you can find information on our website has been released in 2007.
The largest displacement, designed for models Saturn Sky in 2009 - 2.4 liters.
Did you know that: The most expensive modification of the Saturn Sky, according to the manufacturer's recommendations - Red Line Hydro Blue Ltd Ed 2dr Convertible (2.0L 4cyl Turbo 5M) - $33680.
For models of the Saturn Sky in 2009 were used the following colors in the color of body: Black Onyx, Chili Pepper Red, Evening Blue, Forest Green, Hydro Blue, Polar White, Ruby Red, Silver Pearl, Sunburst Yellow, Techno Gray.
Most of all modifications Saturn Sky 2009 weighs Red Line Hydro Blue Ltd Ed 2dr Convertible (2.0L 4cyl Turbo 5M) - 2990 Lbs. | 2019-04-19T19:18:54Z | http://zombdrive.com/saturn/2009/saturn-sky.html |
© Copyright 2010-2012. Kreps Law Firm, LLC - Tuscaloosa, Alabama DUI Defense Lawyers. All rights reserved. Note: Kreps Law Firm, LLC has a centrally located office in Birmingham at 502 Montgomery Hwy. Ste. 202 and will handle cases in any court throughout the state of Alabama. Any city or county designation in this site is to indicate that we have or will handle cases in the cities and counties named. Call us today at (866) 348-2889. | 2019-04-24T12:32:45Z | http://www.tuscaloosaduiattorney.com/blog/2012/03/ |
"In the tradition of Robin Cook, Wyler takes us behind the scenes to show us things the medical establishment doesn’t want us to see. DEAD RINGER builds a high-speed plot on a startling but all-too-plausible premise. This is the stuff nightmares are made of."
Internationally renowned neurosurgeon Allen Wyler takes us deep into a nightmarish scenario, shockingly ripped from recent headlines, and delivers a horrifically plausible, page-turning thriller.
I kind of went out on a limb when agreeing to read Dead Ringer and I really wanted to like it. It is not really a genre I read much of (not unless there is a lot of romance in the main plot). I didn’t dislike this book. I want to say that first of all, if you are looking for a straight forward mystery novel I think you might really like this but for me the book was just okay.
The basis of the plot is that there are people (mostly homeless people and working girls) disappearing but no one really takes notice except for a female undercover vice officer who worked the streets to lure men into, well, you get the point and then when the deal was made she would call in the cops who was backing her up. But then our bad guys accidentally grabs a john with one of the working girls and in a one-and-a-million chance the johns severed head ends up on the doctors table of his best friend during a medical conference.
DFH is our bad guys they are a funeral business and besides just burying and cremating people they also have the option for people to donate their body to science. These bodies would go to people who need cadavers (think medical school) but even with the great deal DFH has for this it is obvious that a lot of people do not want strange people poking and prodding at their body for the sake of science even after they are dead.
DFH is one of, if not the most prosperous business of its kind in Seattle but with the lack of people donating to science….there is no way they can be meeting the demands of people who need cadavers, especially for people who require fresh cadavers.
From here we basically go through our main characters Lucas and Wendy trying to get the bad guys who we know without a doubt are guilty, but they can find no solid proof to arrest them. We have a couple important supporting characters in this book as well that help along the plot.
While I did not love or really like this novel, again I did not dislike it either. I found Dead Ringer an okay read and did not have a hard time finishing it; it just was not for me. I had a really hard time connecting with any of the characters, so I was just reading them; I never felt anything toward them as I do usually with books. No sympathy, anger, excitement. It was just... reading.
We have four points of view and they are not hard to follow at all, we also get some in the past scenes with characters ‘remembering’ things that happened in the past (this is just from our head bad guy and Lucas though).
Not only could I not connect with the character but the mystery itself kind of fell flat for me too. We know who the bad guys are as we get their POV, we know they did it, and the on the whole the ending was very anticlimactic and kind of, I do not mean to sound rude, but there was no suspense to it, no omg-on-the-edge-of-my-seat for me.
Honestly one thing I really liked about this book was a supporting character, Wendy’s ex. I am really curious about him and what he does, he presented an air intrigue to me (not to mention he sounded really hot).
Overall Dead Ringer was an okay read, it is easy to follow and very straight forward. Anyone that is looking for a straight forward mystery novel might really enjoy it, I know it has some wonderful reviews and if that is something you like then I urge you to give it a try and to not let my thoughts influence you. Dead Ringer just did not do it for me though. It lacked the emotion, the passion that makes me really love a book and connect with its characters. I do not think that is a refection on the authors writing, again it has honestly has really good reviews, so that is probably more of a reflection on me. | 2019-04-25T01:05:58Z | http://www.full-moon-bites.com/2012/09/review-dead-ringer-by-allen-wyler.html |
Featuring a Crochet Triangle Shawl and Daisy Granny Square Pattern.
Tuesday Party Time! Add Your Projects and PIN Your Favorites Today!
It’s Fall! Let’s Create with these Fantastic PIN Worthy Projects!
Fall and Winter Projects, Recipes and Free Patterns to Knit and Crochet!
Featuring Irish Soda Bread Recipe. Yum!
Features a Chain of Flowers Headband Pattern. | 2019-04-26T10:20:07Z | https://oombawkadesigncrochet.com/tag/pin-spiration-link-party |
Apr 08, 2008—Food retail research and consulting company Food Information Service Europe (FIS Europe) is in discussion with retailers in the Netherlands and Belgium to deploy prefabricated automated stores that sell high-end food or other items to customers. The prefab stores incorporate self-locking doors, RFID technology and cameras, so that no staff is required.
The concept, known as Food Store 24, was inspired by a similar system employed at the Laxomat self-service convenience stores operated by Laxbutiken, a Swedish restaurant operator specializing in salmon. Laxbutiken operates two Laxomat stores—one in the city of Heberg, the other in Ljungskile—where customers can buy salmon, salads and other packaged food, as well as bottled drinks. The store is entirely self-service and requires no staff to transact purchases, thanks to RFID tags on the items and RFID interrogators at the point-of-sale terminals.
In the case of Food Store 24, German systems integrator IAL Automation und Logistik is providing RFID readers, tags and middleware that could be used to create an automated store enabling a business to stay open 24 hours a day without a night staff. Most stores in Europe are typically open from 8 a.m. to 8 p.m. Operating later than that requires extra staff, and even a small store generally necessitates two staff members be on the premises during late hours for security purposes.
The Food Store 24 system, however, could allow a store to operate with no staff present. With this trailer-sized prefabricated stand-alone structure, transportable via tractor trailer, customers could enter anytime of the day or night, select purchases and complete transactions without an employee's assistance. The turnkey solution includes the prefabricated store, says Dieter Niemietz, president of IAL, though some retailers may opt to furnish their own store location and purchase only the RFID solution.
Since the turnkey structure is relatively easy to transport, Niemietz says, it enables retailers and restaurants to take their products and services to the public. He points out that the structure could be placed in crowded parking areas near theaters, concerts or other heavy traffic areas, as well as at ski resorts in the winter, beach areas in the summer, and even residential areas where there is demand. "If the store found out the spot is not very popular," he notes, "they could move it to another location."
The store works like this, according to Sylvia Pfaff, director of FIS Europe: To enter, a customer inserts a credit or debit card in a slot by the front door and inputs the card's four-digit PIN number. If the PIN is accepted, the door unlocks and allows the individual entrance to a lobby area. The card information is then stored in a back-end system, where it can be accessed remotely by the store's owner through a browser link. After the lobby's exterior door closes, a second door unlocks, allowing entrance to the store area itself. | 2019-04-23T02:37:26Z | https://www.rfidjournal.com/articles/view?4008 |
Wouldn’t it be fun to combine two unlikely pieces of catchy music, especially a modern piano piece with a classical piece?
What if we combined music from Overcooked (a videogame) with… Rachmaninoff?
My new friend Sydney joined me on this adventure. She runs Smart Game Piano where she teaches people how to play cool video game music by rote! Check out her website, Instagram, and Youtube!
I’ve started playing Rachmaninoff’s Prelude No 6 again, and it seems challenging to mash with Overcooked, so here we go!
Sydney had the Overcooked menu theme sheet music, and it turns out it’s in the same key as the Prelude, E flat major.
The major difference is the rhythm, as the Overcooked theme is more waltz-like with the jumpy left hand.
I wanted to improvise on this mashup, so I didn’t write anything down. Sydney and I played our own parts separately, but we would send our playing to each other so we could start off where the other person ended, to get a cohesive piece.
The Prelude has a lot of flowy left hand action and big chords in the right hand, whereas Overcooked has more block chords, like a waltz.
When I transition from Overcooked to Prelude, I keep the waltz-y left hand for a few bars (more on this later).
That’s a good rule of thumb for mashing: when you’re transitioning from one piece to the other, keep one element consistent from the old piece for a few bars, so it doesn’t sound like you completely switched to a new piece.
b. Find chords to transition!
Overcooked uses dissonant chords (we’re lucky with the music! As you may know, Rach enjoys funky chords) like iv flat 3, raising or lowering the thirds for the cute, quirky theme.
At first, I pivoted from one piece to the other using chords that are either almost identical or almost beside it, so I can invent a flat 3 chord and go back to the other piece.
For example, many of the Prelude No 6 passages have a C minor 7 chord, and one of the main Overcooked themes starts with a C minor chord, which I can easily add a 7th (B flat) to, without sounding too out of whack. I can use that chord as a transition, or pivot, between the pieces.
I experimented with different patterns in the left hand because I didn’t want to suddenly start playing block chords in Overcooked.
My go-to is playing broken triads, but it feels like a drastic change from the chromatics.
Finally, I figured out that if I play triads with a lot of passing chromatic tones between the triad notes, it sounds more like Rachmaninoff. E.g. for an A flat major chord, I’d play A flat, B flat, B natural, C, D, E flat, E, and so on.
The fun and challenging part is not picking pivot chords to move from one song to the other. It’s inventing your own pivot chords and segments so that the transitions are your own.
When I’m doing this, I don’t think about the music theory or chords in my head. I’m still learning this, but I’ll try my best to explain.
and eventually to vi, which is the destination C minor chord.
A good starting point for improv is knowing which chords progressions typically sound pleasant. There are a bunch of common progressions like, ii-vii7-I, ii-V-I, I-V-VII, and if you play them obsessively enough, you’ll be able to roll them off without thinking.
I–VI–IV–V(6/4)–V(8–7)–I is the required ARCT technique cadence, and it’s actually really useful for improv.
Sydney starts by playing the Overcooked theme, then adding a few Prelude chords in the right hand. She sends this to me.
Then I play Overcooked where she left off, and transition to the Prelude using some of the pivot techniques above.
We go back and forth a few times.
“I don’t know how I’ll top that,” Sydney says.
Then, she pulls out a mystery surprise in the end.
I can transition pretty smoothly between the two pieces of music now, and add my own transition sections.
When you’re starting to mash music on-the-fly (improvise), try to pick similar enough pieces of music, and know your cadences.
Improv takes practice. If you pretend there’s a screechy record player inside your piano and expect to hear wacky chords once in a while, you should be fine.
Alright, let me know… what did you think of our mashup? If you’re wondering how to learn music faster, check out my chunking technique. | 2019-04-23T12:09:12Z | https://artiden.com/song-mashup/ |
Emily Warren is Managing Director of The Webby Awards, the world’s premiere honor for online excellence, and of IADAS, the International Academy of Digital Arts & Sciences, the presenting and judging body of the Webbys. She started her career in publishing with Time Warner, and then ran the awards programs at The Art Directors Club in New York. At ADC Emily edited the Art Directors Annual which subsequently was recognized by One Show Design and the American In-House design awards. Since joining The Webby Awards Emily has spearheaded the Webby International Ambassador program and produced conferences and events around the world on their behalf. Emily speaks pretty good Italian, has been dancing since the age of 3, and holds a B.A. in English from Wesleyan University. Emily is a current member of Precision Dance NYC and lives in Brooklyn with her husband and their shelter dog, Cindy.
IDEAS: The International Academy of Digital Arts and Sciences was founded in 1998 to help drive the creative, technical, and professional progress of the Internet and evolving forms of interactive media. | 2019-04-20T05:04:20Z | http://99faces.tv/emilywarren/ |
Government Organization: Border Security Force.
Salary Breakup: Rs. 21700 – 69100/- Per Month.
Last Date: 23rd July 2018.
Recruitment Process: Written Examination and Physical Test.
Qualification 10th pass + ITI in the concerned discipline or 3 years experience in the relevant field.
Through Postal Order or Demand Draft in favour of relevant Center.
How to Apply Interested and eligible candidates may apply in prescribed application form along with self-attested copies of relevant documents, two self-attested photographs send to relevant address as official notification on or before 23rd July 2018. | 2019-04-24T00:55:35Z | https://jkalert.com/bsf-recruitment-2018-notification-207-constable-posts/ |
This article has been taken from the June 2014 issue of Aston Martin's official AM Magazine. Available now in Print and App format.
The Atom was an avant-garde prototype developed using an early form of space-frame chassis and independent suspension, while the Cotal semi-automatic gearbox was a forerunner of today’s modern “paddleshifts”. Its key design elements can be seen in the 2-litre Sports, which was the first model produced under David Brown in 1948. That, of course, led to the great classic designs of the iconic DB family (DB2, DB2/4, DB4, DB5 and DB6), which created Aston Martin’s reputation as a manufacturer of the world’s most beautiful sports cars.
Current owner Tom Rollason bought the Atom in 1985 from the Musée de l’Automobile in Chatellerault, where it had been on display for two years after a period in the Le Mans Motor Museum. Aston Martin enthusiast and collector Rollason painstakingly restored it to its 1939 specifications. Among other things, this involved taking out the modern headlamps that had been installed and reverting from a royal blue exterior paint colour to the original silver. In the process, he struck up a firm friendship with Gordon Sutherland and learned much more about the car through their lengthy conversations.
Today, the narrow, winding, dipping, climbing roads where Grover-Williams grew up connect the bustling low-lying harbours with the lofty old town of Monaco-Ville where, if you stand for long enough, will lead you to believe that this is where most of the world’s exotic cars end up. As a result, it takes a truly impressive automobile to turn the head of the average Monégasque—which says a thing or two about the latest addition to the Aston Martin stable, the shamelessly racy Vantage N430.
Stepping through the doors of Nice airport, it was easy to spot the N430, not least because of the vibrant yellow hue accenting the “lipstick” grille surround, snaking up the A-pillars and cant rails, swathing the rear diffuser blade and door mirror caps.
“The Atom encapsulates everything that Aston Martin represents. It was highly fashionable, at the cutting-edge of design and anybody would have been extremely proud to have owned it,” Rollason says.
The interior is equally striking, with airline-style seats in luxurious, deep red leather. The rear seats look spacious—although the narrow doors make it a bit of a squeeze to ease into them.
Rollason continues: “There is also the bonnet release, which is unique to the Atom and not seen on any other Aston Martin. It was designed bespoke for the car in the shape of a Delta wing—another nod to aircraft design—and when viewed side-on, it’s the famous winged logo cut in half.” So what is the car like to drive? “It is quite amazing,” says Rollason. “The very rigid body, which gives the impressive front suspension, is actually a very comfortable ride and actually very modern in its feel. Sutherland’s aim was to avoid too many connections from the engine bay to the cockpit to minimise fumes and noise.
When the Second World War took hold, it meant the second Atom was never built, but Sutherland was not short of ideas on what he wanted to do with it. “He was going to put extra length in the chassis so that it was a true four-door saloon,” Rollason explains. “He also planned to lower the roofline, which would have made it a very streamlined car. And he wanted a smaller petrol tank to increase the boot space and a different gearbox if the Cotal wasn’t available. There were also going to be some changes to the rear braking system.” In fact, Sutherland test drove the car for more than 90,000 miles during the War years, conscious of how important it would be for the marque once production resumed after the conflict had ended. But after Brown bought the company he wanted the first car built on his watch to be a roadster rather than a sedan so the Atom was destined to stay a unique, one-off.
As this remarkable feat of engineering and design shimmers in the spring sunshine, it’s clear this embodiment of Aston Martin’s core design values, glorious curves and perfect proportions will look young at heart and instantly recognisable for years to come. | 2019-04-18T20:47:50Z | https://www2.astonmartin.com/live/blog/aston-martin-live/2014/07/05/back-to-the-future---the-aston-martin-atom |
In this post I offer 10 ways to keep the flame burning in your marriage after the babies arrive. Having been married almost 12 years, I know the dynamics of a relationship change after having children. It takes a little more effort and time to keep the marriage fresh and like new.
Remember being married should be and is fun!
1. Don’t stop dating! Make time for regular date nights to catch up with one another without the children. Make sure to not talk about anything kid related either. It won’t hurt!
2. Don’t have the same bed time as the children. Put the kids to bed earlier so you can have alone time as a couple.
3. Take a vacation just the two of you, kid free.
4. Be creative with intimacy.
5. Can’t find a babysitter? Have date night at home after putting the kids to bed a little earlier.
6. If you’re a stay at home mom, please don’t look like it! Make sure you take the time to keep yourself looking put together. Put those sweats and yoga pants far, far away.
7. When you’re with your spouse, make sure to keep the phones/laptops/iPads put away. Give each other your full attention. No one wants to talk while the other is checking text messages. It sends a signal that what the other person has to say is unimportant.
8. Don’t burden one another with the days problems as soon as you see/talk to one another after work. Have time to wind down and take a breather first.
9. Stay light hearted. Joke with one another, laugh. It’s good for the soul.
10. Always see the beauty in your spouse instead of their faults. | 2019-04-21T06:10:52Z | http://www.mommyweek.com/keep-the-flame-burning/ |
It’s that point of year again, time for our “Best of 2013” series, where we glance back over the last year and pick our favourite freebies and resources. To kick things off, we’ve went back through each of the free fonts we’ve discovered previously year, and selected those that we feel stand out above the remainder. Be sure to download your favorites to begin 2014 right – with a fresh font library. | 2019-04-25T17:48:39Z | http://www.webdesignco.co.uk/2013/12/best-free-fonts-of-2013/ |
The makeup artist behind the Duchess of Sussex's wedding day look is set to release a specially-designed cosmetics bag.
Daniel Martin has joined forces with the apparel and accessories brand Cuyana to create the item, which is both practical and pleasing to the eye.
Martin was behind actress Meghan Markle's unforgettable look at the royal wedding in May (18), when she became Prince Harry's wife.
The 37 year old expectant mum, was also seen carrying one of the brand's chain-strap bags during her recent Australian and New Zealand tour with the Prince.
Martin began working with Markle when she was among the stars of drama series Suits and he was personally asked by the brunette beauty to be a part of her big day.
"Because we've known each other for so long and I knew exactly what she wanted, it was kind of a no-brainer the day of," he told Vogue of preparing for the big day. “Because of Meghan, people are feeling comfortable in their own skin. They don’t need to wear so much make-up. After the wedding I had so many moms reach out to me through DM (direct messenger) saying, ‘thank you for showing my 14-year-old daughter that she doesn’t need to go to school with a full face of make-up’. I didn’t realise how much makeup the world was wearing!"
Martin's roster of celebrity clients also includes Jessica Alba, Jessica Biel and Elisabeth Moss.
His new leather makeup carrier is a large, flat-bottomed rectangular case that can hold bulkier items but maintains a slim, wallet-like size. The item is offered in five colours - including black and burgundy.
Proceeds from the Vanity Case, which retails for $110 (£84), will benefit nonprofit organisation H.E.A.R.T., which aims to support survivors of abuse and neglect. | 2019-04-24T21:58:59Z | https://www.thebeat925.ca/news/showbiz/164336/duchess-of-sussexs-makeup-artist-to-release-cosmetics-bag |
They are glimpses of everyday life in Belarus, a country not often viewed in such intimate detail. Belarus gained its independence from USSR in 1991, but maintains close ties to Russia and remains under the dictatorship of Alexander Lukashenko. The 2013 Press Freedom Index compiled by Reporters Without Borders, listed Belarus 157th among the 179 countries studied.
These are the winning images for the annual independent Belarus photo exhibit, the photos show everything from a marriage, to wide-eyed owls, from sporting events to protests.
But in 2012, organizers of the exhibit were detained briefly and questioned by authorities as they returned to Belarus from an exhibit of the photos in Lithuania. They were accused of organizing an "extremist" exhibit and books containing the images were seized. The photos were deemed to "insult the national honor and dignity of the citizens." The arbitrary harassment underscored the challenges faced by Byelorussian journalists, which the Committee to Protect Journalists has listed as one of the world's 10 most censored countries.
The CJFE 2013 Photo Exhibit, sponsored by Henry's Camera and the Toronto Star, is proud to present these award-winning, uncensored photos. Sometimes what you don't know, CAN hurt you.
At our 16th annual CJFE Gala: A Night to Honour Courageous Reporting, prints of the photos below were available for purchase. There are still a number of prints available. If you are interested, please contact Tom Henheffer at thenheffer@cjfe.org or 416-515-9622, ext. 226 for more details. | 2019-04-22T20:52:13Z | https://www.cjfe.org/resources/photo-galleries/2013/2013-cjfe-photo-exhibit-belarus |
A new study from the University of Houston Department of Health and Human Performance finds a child's risk for obesity or malnutrition may be tied to the mother's misperception of her child's weight status. A key to understanding this phenomenon may lie in how she regards her own weight status. Researchers say the situation shows that healthcare providers need to broaden their health care screenings.
The study, titled "Low-Income Immigrant Hispanic Mothers' Concerns and Perceptions of Their Young Child's Weight," examined survey responses from 70 low-income immigrant Hispanic mothers. Assistant professor Daphne Hernandez notes that many mothers accurately estimated their children's weight, but more than 54 percent of mothers with an overweight or obese child perceived him or her as having a healthy weight.
"It is difficult to decrease the childhood obesity prevalence rates if parents are not able to accurately detect that their children are overweight or obese," Hernandez said. "They may perceive that their child will not have weight problems in the future once he grows taller or becomes older, but the situation clearly requires an intervention that explains and promotes a healthy lifestyle."
The study also found that mothers who perceived their child to be in fair or poor health were more likely to underestimate their weight. "In these cases, mothers seem to link 'health' with 'weight.' They may believe that more weight is needed to help improve the child's health," she said. "The mentality that a 'chubby baby is a healthy baby' may still be preferred. So the way mothers perceive their children's health appears to be closely tied to their weight status."
One critical factor is the level of concern that mothers have regarding their own weight. In the study, mothers who were concerned about becoming overweight also were more concerned that their child would become overweight in the future.
Hernandez says public health nurses, especially those who are bilingual, can develop brief health screenings that focus on a mother's concerns about her weight and that of her child. These brief interventions can be part of a well-child doctor visit.
"For instance, nurses can engage in a conversation with mothers about the importance of eating fruits and vegetables on a limited budget, reducing sugary drinks and snacks that are high in sugar or salt," she said. "They also can educate on the importance of getting enough sleep and increasing physical activity, even where there is not a lot of space indoors or out."
She adds these interventions also can serve as an assessment of the mothers' parenting practices around health and knowledge of how these behaviors affect their children's weight.
"Health care practitioners can assist by explaining how a child's weight and height are used to calculate a body mass index," she said. "They also can discuss the health problems that go along with being overweight or obese, like type 2 diabetes or hypertension."
Hernandez's research focuses on the complex factors that may lead to obesity, such as poverty, stress, family structure and social support. The study was published in the journal Public Health Nursing. | 2019-04-21T01:15:42Z | https://www.eurekalert.org/pub_releases/2016-04/uoh-com042016.php |
HD WRAP AROUND Reviews and online ordering or you can review HD WRAP AROUND.
HD Vision WrapArounds are lightweight sunglasses that wrap around your prescription lenses. HD Vision's glare-blocking technology enhances clarity and color while their modern European styling prevents light from entering in on the sides. For only $19.99 plus $6.99 shipping for US and $9.99 shipping for Canada. As a bonus, we will also send you our Night Vision WrapArounds perfect for improving your vision when driving at night, FREE just pay $5.99 for shipping and handling.
Product includes: HD Vision WrapArounds and Visor Clip. | 2019-04-19T20:42:28Z | http://tv-product-reviews.com/detail.asp?prodID=13075 |
A liquid applicator is provided which is particularly useful in applying preoperative surgical scrubs or paints to skin. The liquid is contained in a frangible ampoule inside the body of the applicator. This ampoule is supported and protected by a deformable element that prevents unintentional breakage of the ampoule from impacts during storage and handling before use. The applicator is actuated by pushing at least a portion of the frangible ampoule through an aperture in the deformable element and into contact with a means for breaking the ampoule.
This is a continuation of U.S. Ser. No. 07/985,306 filed Dec. 4, 1992 now U.S. Pat. No. 5,288,159.
This invention relates to liquid applicators having particular utility in the field of surgery preparation. Most particularly, this invention relates to articles useful in applying pre-operative surgical scrubs or paints to skin.
Antiseptic preparation of patients for surgery conventionally includes a 3-10 minute scrubbing of the affected area with a soap solution followed by the application of a water-soluble antiseptic paint solution. These solutions are generally applied with saturated sponges that are attached to a blade or held with forceps. The sponges are saturated by soaking in open pans of solution.
U.S. Pat. Nos. 4,415,288; 4,507,111; and 4,498,796 describe surgical scrub devices that include a liquid-containing, rupturable, cylindrical cartridge which is slidable within a tubular handle having one or two longitudinally oriented hollow spikes that communicate to recesses in the interior of a sponge. Sliding the cartridge in the tubular handle causes the spikes to rupture one end of the cartridge. Liquid from the cartridge flows through the lumen of the spikes to the sponge. To prevent rupture of the cartridge by the spikes from impact during, for example, shipping, an embodiment of the device incorporates an inwardly projecting shoulder in the tubular handle that may interfere with the sliding of the cartridge. Ease of actuation is also a potential problem with an applicator that requires puncturing a plastic cartridge.
U.S. Pat. No. 4,183,684 describes a fluid dispenser that includes a liquid-containing ampoule in a flexible housing. A porous pad element is disposed over the bottom opening. The liquid is released to the porous pad by crushing the ampoule through the flexible housing walls.
U.S. Pat. No. 4,957,385 describes a dispensing applicator having a wedge used for breaking a frangible ampoule.
U.S. Pat. No. 4,528,268 to Andersen et al. discloses an apparatus for testing the sufficiency of sterilization. It includes an ampoule containing a sterile liquid culture medium which is broken by the user when a plunger pushes the ampoule against an opening wedge.
Coassigned U.S. Pat. No. 4,925,327, which is hereby incorporated by reference, describes a liquid applicator which incorporates a rigid, porous metering insert to regulate the flow rate of liquid disposed between the applicator handle and a foam sponge covering a major orifice of the handle. The liquid to be dispensed is contained in a rupturable reservoir removably affixed at the other major orifice of the handle. Since no means is provided for protecting the reservoir container, plastic is the preferred container material. However, plastic containers can limit the shelf life of many antiseptic solutions.
(d) means associated with the hollow elongate member for rupturing the reservoir container after at least a portion of the container is pushed through the aperture in the deformable means. Although this device can be easily actuated by the application of a small steady force to push the reservoir container through the deformable means and into contact with the rupture means, the liquid-filled rupturable container is protected from breakage from large impact forces which may occur during shipping or handling.
(g) means of maintaining atmospheric pressure within the hollow elongate member while the liquid is being dispensed.
This embodiment of the applicator provides a means to reliably deliver in a short period of time a surgical prep solution to the applicator sponge without dripping. The applicator controls the flow rate of liquid therein to the applicator sponge without the need for external operator manipulation such as squeezing the liquid container or compressing the applicator sponge against an external surface. Although intended to apply modern, low viscosity, non-water-soluble, film-forming prep solutions, this device can be configured to apply a variety of solution compositions, viscosities, densities and volumes without compromising the fast wetting and no dripping features.
FIG. 10 is a magnified plan view of the membrane fabricated in Example 3, pore sizes not to scale.
With reference to the embodiment depicted in FIGS. 1 through 6, the applicator 10 includes a hollow elongate member 12 adapted to support and protect a rupturable reservoir container in the form of frangible ampoule 14 containing the solution to be applied by the applicator 10. The hollow elongate member 12 acts as a handle and as a fluid container after the ampoule 14 has been broken, but before the solution is dispensed by the foam sponge 16. The hollow elongate member 12 is bounded by a first major orifice 18 and second major orifice 20, one at each end. A flange 22 adapted to accept the foam sponge 16 surrounds the first orifice 18. Internally, the hollow elongate member 12 is conveniently constructed to include a shoulder 24 for retaining a collar 26, which serves as a preferred deformable means for supporting and protecting the ampoule 14 until the applicator 10 is to be used. A wedge 28 is conveniently constructed adjacent to the first orifice 18, which serves as a means for breaking the ampoule 14.
Referring to FIG. 6, the collar 26 is conveniently constructed to include a plurality of radially projecting, cantilevered beam elements 36 projecting at a substantially right angle from a surrounding annular rim 38. In particularly preferred embodiments, the inside edge 40 of each of the cantilevered beam elements 36 is curved, and together these curves define an aperture 42. This aperture is specifically adapted to engage the bulb 44 of the neck portion 46 of the ampoule 14.
In the embodiment depicted, the collar 26 is disposed between the first 18 and second 20 orifices of the hollow elongate member 12 at a position that is conveniently determined by an internal shoulder 24. Prior to actuation, the collar 26 prevents the neck portion 46 of the ampoule 14 from contacting the wedge 28. During actuation of the applicator 10, the bulb 44 of the ampoule neck portion 46 is pushed through the collar 26, causing the ampoule neck portion 46 to contact the wedge 28. The wedge 28 exerts a force perpendicular to the axis of the neck portion 46 of the ampoule 14 that results in the separation of the ampoule neck portion 46 from the ampoule body portion 48. This separation is facilitated by a stress-concentrator 50 between the ampoule neck portion 46 and body portion 48.
Referring to FIG. 3, after the separation, the collar 26 acts to axially separate the ampoule neck portion 46 from the body portion 48, facilitating the flow of liquid from the ampoule 14. If the ampoule neck 46 were to remain in close proximity to the ampoule body 48, the opening 52 formed by the rupturing of the stress-concentrator 50 for the liquid to escape the ampoule 14 could be restricted.
The cap 32 is adapted to close the second orifice 20 of the hollow elongate member 12 after insertion of the liquid-containing ampoule 14 during assembly of the applicator 10. The cap 32 is constructed to transmit the actuation force to the ampoule 14, vent the interior of the applicator to prevent "air-locking" and provide a leakproof seal. The cap 32 is axially retained to the hollow elongate member 12 by a snap fit joint created by the internally projecting lip 54 of the cap 32 and the externally projecting ridge 30 of the hollow elongate member 12. The cap 32 is constructed to include an axially projecting column 58 from the interior surface. The column 58 contains an axial hole that vents the interior of the applicator 10 to maintain atmospheric pressure as liquid flows out through the first orifice 18 of the hollow elongate member 12 into the foam sponge 16.
Referring now to FIGS. 4 and 5, in a preferred embodiment, a flexible, porous layer 66 of porous material incorporated in a structurally rigid frame 68 is disposed over the first orifice 18 of the hollow elongate member 12, and is sandwiched between the surrounding flange 22 and the open-cell foam sponge 16. The porous layer 66 is disposed over the first orifice 18 to control the flow of liquid out of the hollow elongate member 12 and into the foam sponge 16.
The foam sponge 16 can be selected from a variety of commercially available materials having a wide range of compression set ratios, densities and porosities. By varying the pore size, pore size distribution, void volume fraction and surface energy of the flexible porous layer and the compression set ratio and porosity of the foam sponge, applicators can be constructed to apply a variety of solution compositions, viscosities and volumes. The pore size, pore size distribution, void volume fraction and surface energy of the flexible porous layer and the compression set ratio and porosity of the open-cell foam sponge are adjusted in relation to the viscosity, density, volume and surface tension of the liquid to be dispensed to allow a portion of the liquid contained in the applicator to flow to the outer surface of the foam sponge without dripping when the applicator is suspended with the flange down. It should be noted that to create a completely dripless applicator, the amount of liquid to be dispensed by the device must not exceed the reservoiring capacity of the foam sponge.
The invention will now be more particularly described in terms of the following particularly preferred embodiment. Referring to FIGS. 1-3, the applicator 10 consists of the following components: a frangible ampoule 14 containing the solution to be dispensed; a hollow elongate member 12 adapted to accept the ampoule 14, and having a flange 22 surrounding a first orifice 18; a deformable collar 26 disposed within the hollow elongate member 12; a cap 32 including an air vent 64 positioned over the second major orifice 20 of the hollow elongate member 12; an integral metering/bonding insert 72 disposed within the flange 22 of the hollow elongate member 12; and a foam sponge 16 disposed over the metering/bonding insert 72.
The frangible ampoule 14 is preferably made of glass, with a stress-concentrator 50 at a constriction separating a neck portion 46 from the body portion 48 of the ampoule 14. The neck portion 46 of the ampoule 14 includes a bulb 44 disposed between the lower end 74 of the neck portion 46 and the stress concentrator 50 of the ampoule. Frangible ampoules such as this are well known in the pharmaceutical field.
The hollow elongate member 12 can be molded from any thermoplastic material compatible with the liquid to be dispensed. Preferably, the hollow elongate member 12 is molded from high density polyethylene. Features of the preferred embodiment of this component include a tubular handle portion 13, a dispensing portion 15, a first major orifice 18 with an integrally formed radially-projecting surrounding flange 22 adapted to accept the metering/bonding insert 72, a wedge 28 adjacent to the first orifice 18, a second major orifice 20 with a surrounding ridge 30 on the exterior surface of the hollow elongate member adapted to retain a cap 32, and a shoulder 24 disposed between the first orifice 18 and second orifice 20 adapted to support a collar 26.
For surgical prep applications, it is important that the hollow elongate member 12 be long enough to prevent contact of the patient by the person applying the surgical prep solution. Preferably, for such applications the hollow elongate member is at least four inches long. In the preferred embodiment, the tubular handle portion 13 of the hollow elongate member has a larger diameter to accommodate the body of the ampoule, than the dispensing portion 15 which accommodates the neck portion 46 of the ampoule.
Integrally-formed flange 22 surrounds the first orifice 18 and is angled from the longitudinal axis of the elongate member 12 by between 30 and 90 degrees. Most preferably, there is about a 45 degree angle between the flange 22 and the longitudinal axis of the hollow elongate member 12. The flange 22 preferably includes a recess 70 on the its interior surface. The recess is dimensioned and shaped to permit nesting therein of the metering/bonding insert 72.
Wedge 28 is positioned to extend within the dispensing portion 15 of the hollow elongate member 12 near the first orifice 18 so as to be capable of contacting the end 74 of the ampoule neck portion 46 when the applicator 10 is actuated. Many different geometries are possible for the wedge 28. The preferred embodiment includes an integrally-formed projection with a first edge 76 at an angle from the longitudinal axis of the hollow elongate member 12 of 30 to 60 degrees, most preferably about 45 degress, and a second edge 78 parallel to the longitudinal axis. When the bulb 44 of ampoule 14 is pushed through the opening in collar 26 and towards the first orifice 18 of the hollow elongate member 12, the first edge 76 of the wedge 28 exerts a force perpendicular to the axis of elongate member 12 on the ampoule neck portion 46 which ruptures ampoule 14 at the stress concentrator 50. The ampoule neck portion 46 is wedged between the second edge 78 of the wedge 28 and the interior wall 80 of the tubular handle 13 opposite the wedge 28. Many geometric variations of wedge 28 capable of exerting such a perpendicular force on the ampoule neck 46 when the ampoule 14 is displaced will occur to the skilled artisan.
The hollow elongate member 12 has an internal diameter transition between the tubular handle portion 13 and the dispensing portion 15 which provides an inwardly projecting shoulder 24 that limits the axial displacement of a collar 26. Collar 26 serves as the deformable means which support ampoule 14 and prevents unintentional breakage of the ampoule due to impact forces during shipment and storage. The collar 26 is conveniently constructed from a thermoplastic material. In the preferred embodiment, the collar 26 is injection molded from high density polyethylene. Referring to FIG. 6, the collar 26 preferably includes a plurality of radially projecting beam elements 36 cantilevered at an approximately right angle from a surrounding annular rim 38. Most preferably, the cantilevered beam elements project from one edge of the surrounding annular rim The inside edges 40 of the radially projecting beam elements define a central aperture 42. The central aperture 42 is nominally the same diameter as the lower end 74 of the ampoule neck portion 46 but significantly smaller than the diameter of the ampoule bulb 44. During assembly of the applicator 10, the collar 26 is inserted annular rim 38 up through second orifice 20 into the hollow elongate member 12 to the level of the shoulder 24. Annular rim 38 lies adjacent shoulder 24, with its outer surface abutting handle portion 13 of the hollow elongate member just above the shoulder portion around the entire perimeter of the annular rim. Ampoule 14 is inserted in the hollow elongate member, lower end 74 first. The ampoule neck portion 46 partially projects through the collar 26; however, the central aperture in the collar 26 is dimensioned such that in the assembled applicator, the bulb 44 of the ampoule neck portion 46 is not completely through the aperture The beam elements 36 exert a spring force on the bulb 44 of the ampoule neck 46 and prevent the lower end 74 of the ampoule neck portion 46 from contacting the wedge 28 The beam elements 36 dissipate impact or shock forces on the ampoule 14 that might occur during shipping. When the applicator is actuated, the beam elements 36 and the surrounding annular rim 38 elastically and plastically deflect as the ampoule bulb 44 is pushed through the collar 26 and into contact with wedge 28.
In the preferred embodiment, the beam elements 36 are cantilevered from a thin annular rim 38. The rim 38 is designed to deflect when the beam elements 36 exert a critical bending moment upon it. This deflection of the rim effectively reduces the spring constant of the beam elements which produces a substantially constant force upon ampoule bulb 44 being forced through the aperture 42 that is independent of ampoule bulb diameter. Without this effect, the force required to push an ampoule through the aperture 42 in collar 26 would be nonlinearly related to the diameter of the ampoule bulb 44. Because glass ampoules of the type incorporated in this applicator are not manufactured by a blow molding process, the diameter of the bulb portion 44 of the ampoule 14 is significantly variable. Thus, without the use of the collar described herein, the force required to actuate each applicator would vary with each ampoule containing liquid to be dispensed. Preferably, the collar 26 is adapted to withstand the application of 13 to 18 Newtons of force without sufficient deflection to allow the ampoule bulb 44 to pass through aperture 42, but deflects to allow the ampoule bulb to pass through the aperture upon application of at least about 22 Newtons of force.
In the preferred embodiment, a cap 32 covers the second major orifice 20 of the hollow elongate member 12. The cap includes an end wall 59 and annular side walls 61. The cap 32 can be fabricated from any compatible thermoplastic material. In the preferred embodiment, the cap element is injection molded from high density polyethylene. The cap is adapted to be attached to hollow elongate member 12 by means of a snap fit. This is accomplished by providing lip 54 inwardly projecting from side walls 61 adjacent to the major orifice 56 of the cap 32 which has a smaller inside diameter than the outside diameter of the outwardly projecting ridge 30 adjacent to the second orifice 20 of the hollow elongate member 12. When the applicator 10 is assembled, the lip 54 of cap 32 is snapped over the outwardly projecting ridge 30 on the hollow elongate member 12. The cap 32 is also adapted to provide a liquid seal between the cap 32 and the hollow elongate member 12. This is accomplished by providing that the inside diameter of the inwardly projecting lip 54 on the cap 32 is smaller than the outside diameter of the sealing surface 34 of the hollow elongate member 12 thereby providing an axially slidable seal by means of an interference fit.
The cap 32 is adapted to transmit an actuation force to the glass ampoule 14 as the cap is axially displaced in the direction towards sponge 16. This force is transmitted by column 58 which axially projects from the interior surface of the end wall 59 of cap 32. Axial movement of column 58 in the direction towards sponge 16 forces the entire neck 46 of ampoule 14 through the aperture 42 in collar 26 and causes the ampoule neck 46 to contact the wedge 28. In order to avoid creating a vacuum and restricting flow through the applicator, a means of maintaining atmospheric pressure in the device is preferably employed. Thus, in the preferred embodiment illustrated, column 58 is constructed with an axial hole with a first larger orifice 82 that communicates to the external surface of the cap, and an air vent 64 at the end of the column 58. The axial hole in the cap 32 functions to aspirate air into the internal volume of the applicator as the liquid flows into the foam sponge 16 to maintain atmospheric pressure within the device and prevent "air-locking." Of course, other air vent means are envisioned by the inventors. Preferably, the geometry and location of the air vent would not result in leakage of liquid from the device. The annular volume between the end wall 59 and axial column 58 of the cap 32 and the inside surface 62 of the hollow elongate member 12 adjacent to the second orifice 20 provides a reservoir for liquid when the applicator 10 is inverted. The height of column 58 is designed to always exceed the level of liquid in the annular volume thereby preventing liquid from leaking out of the air vent 64 of the column 58.
Referring to FIGS. 4 and 5, metering/bonding insert 72 which is dimensioned to rest in recess 70 of flange 22, includes a flexible porous layer 66 of porous material surrounded by a substantially rigid frame 68, preferably fabricated from thermoplastic material. The metering/bonding insert 72 can be fabricated by attaching the porous layer 66 to separate rigid frame 68 by means of adhesives, thermal staking, ultrasonic bonding and other methods. Rigid frame 68 can be fabricated by injection molding, extrusion and die cutting. In the preferred embodiment the metering/bonding insert 72 is fabricated by injection insert molding a thermoplastic rigid frame 68 around the porous layer 66. Preferably, rigid frame 68 is comprised of a thermoplastic or heat-activatable material filled with an inductively active material. Preferred examples include thermoplastic or heat-activatable material, such as polyethylene or hot melt adhesive, filled with an inductive metal or metal oxide powder, e.g., 5 to 50 percent by volume iron powder having an average particle size of about 300 to 400 mesh. A particularly preferred material is polyethylene filled with iron powder, commercially available from Ashland Chemical, Inc., Norwood, New Jersey, as "EMAWELD® Resin G10-214". During assembly of the applicator 10, the metering/bonding insert 72 is sandwiched between the flange 22 surrounding the first orifice 18 of the hollow elongate member 12 and the foam sponge 16. The assembled applicator 10 is then held in an inductively inactive fixture, e.g., plastic, and exposed to a high frequency alternating electromagnetic field. The frame 68 of the metering/bonding insert 72 is inductively melted thereby bonding the hollow elongate member 12, the metering/bonding insert 72, and foam sponge 16 together.
The distribution and rate of delivery of the liquid to the open-cell foam sponge 16 is controlled by the porous layer 66 incorporated in the integral metering/bonding insert 72. For a given volume, viscosity, density and surface tension of the liquid, wetting of the foam sponge without dripping can be accomplished by appropriate specification of the average pore size, pore size distribution, void volume fraction and surface energy of the material from which the porous layer 66 is formed, and the permanent compression set ratio and porosity of the open-cell foam sponge 16.
Preferably, the pore size, pore size distribution, void volume fraction and surface energy of the porous layer 66 incorporated in the metering/bonding insert 72 are adjusted so that for any given volume, viscosity, density and surface tension of the liquid to be applied the average flow rate of the liquid through the porous layer is between about 0.1 and 15 ml/sec. Greater flow rates than this will tend to result in an applicator which drips and applies uneven coats, while lower flow rates will result in an applicator which does not provide adequate liquid for surgical scrub applications. Most preferably, for surgical scrub applications the average flow rate of liquid through the porous layer 66 is between 0.25 and 10 ml/sec. In general, for lower volumes and/or higher viscosity liquids the pore size and/or void volume of the porous layer is adjusted upwards to achieve the desired flow rates.
The rigidity provided by the structural frame 68 of the bonding/metering insert 72 enables flexible porous materials to be utilized as the porous layer 66 that would otherwise be difficult to handle in manufacturing. The structural frame 68 permits the use of inexpensive porous materials manufactured as sheets as the porous layer 66 to control the liquid flow rate. Combining the inductively meltable frame 68 with the porous layer 66 reduces the manufacturing cost of the applicator by allowing the utilization of inexpensive porous material and by reducing the number of parts. Insert molding an inductively meltable frame 68 around the flexible porous layer 66 results in a single part that can be easily handled by automated production equipment.
The porous layer in the metering/bonding element 72 is preferably a flexible fabric, porous film or porous membrane, such as porous plastic film or porous metal foil, and flexible nonwoven porous material. Useful fabrics may be woven, non-woven or knit. By flexible it is meant that the material from which the porous layer is made can be wrapped around a 1 millimeter diameter mandrel without breaking. While flexible porous layers are preferred, rigid porous metering material, such as that described in U.S. Pat. No. 4,925,327, incorporated herein by reference, may also be employed. Preferably, the average pore size of the porous layer is between about 1 and 100 microns and the void volume fraction is between about 0.5 and 50 percent. Preferably, for surgical applications where antiseptic solutions are dispensed, the average pore size of the porous layer is between 3 and 65 microns and the void volume fraction is between about 1 and 35 percent. Most preferably, for such applications the average pore size is between about 5 and 50 microns and the void volume is between about 2 and 20 percent. The distribution of the pore sizes are preferably less than about 30 percent of the average pore size, more preferably less than about 20 percent, and most preferably less than about 10 percent of the average pore size. Illustrative examples of materials which may be used to make the flexible porous layer useful in the practice of the invention include: polyvinyls such as acrylics and methacrylics, polyynes, polyenes (e.g., polyethylene, polypropylene, and polystyrene, polydienes (e.g., polybutadiene and polyisoprene), polyesters (e.g., terephphalate esters, etc.), polyurethanes, polyamides (e.g., nylons), polyimides, polyethers, polyacrylamides, polyacrylonitriles, polycarbonates, etc. A preferred woven fabric from which to form porous layer 66 is commercially available as "Saatifil™ Polyester PES 18-13" from Saati Corp., Stamford, Conn. This material has an average mesh size of about 18 microns and a void volume fraction of about 13 percent. Preferred porous layers would include porous polymer films produced by phase inversion, laser ablation and other well known processes.
The material from which to form porous layer 66 is selected so as to have an appropriate surface energy for the liquid to be dispensed by the applicator. For example, where the liquid to be applied has relatively high surface tension, such as water, the porous layer 66 is made from a material which has relatively high surface energy, such as polyacrylamide. In this way, wetting of the porous layer 66 by the high surface tension liquid is assured. With liquids having relatively low surface tensions, such as isopropyl-alcohol or ethanol, the choice of the material from which to form porous layer 66 is less important, since liquids with low surface tensions will wet porous layers with high or low surface energies. Preferably the porous layer is between about 5 microns (0.2 mil) and 525 microns (20 mil) thick, more preferably between about 12 microns (0.5 mil) and 50 microns (2 mil) thick.
One type of useful flexible porous layer is a microstructured isoporous membrane having an array of pores therein, described in commonly assigned U.S. patent application Ser. No. 07/804,294, filed Dec. 9, 1991, incorporated herein by reference. These membranes comprise a sheet having first and second major faces with at least one array of pores that extend through the entirety of the sheet from the first face to the second face.
e) the land areas between pore openings are flat.
FIG. 7 shows an illustrative embodiment of a microstructured membrane made in accordance with U.S. Ser. No. 07/804,294, wherein membrane 100 comprises sheet 120 with pores 140 therein. Pores 140 open in first face 160 of sheet 120 and extend through the entirety of sheet 120 to open through second face 180.
An additional feature of some embodiments of these membranes is that, referring to FIG. 7, major portion 121 of the walls of each pore 140 are substantially parallel to longitudinal axis 122 of pore 140. As used herein, "longitudinal axis" refers to the axis of the orifice extending through the sheet 120. By "substantially parallel" it is meant that the deviation between the major portion of the wall of each opening and the longitudinal axis is less than about 5 degrees. Accordingly, in these embodiments the pore has a substantially uniform cross-sectional area throughout at least the portion defined by the major portions of its walls. As used herein, "cross-sectional area" refers to the area of a geometric surface on a plane perpendicular to the longitudinal axis of the pore and bounded by the intersection of the plane with the walls of the opening.
In these membranes the major portion, i.e., at least 50 percent and typically preferably at least 75 percent, of the length of the walls of each pore beginning at the edge of the opening in the first face of the sheet and extending through the sheet are substantially straight. Explained in another way, the regions of intersection with the walls or sides of an a pore of any plane parallel to and intersecting the longitudinal axis of the pore are straight lines for at least 50 percent and typically preferably at least 75 percent of the length of the regions of intersection.
These membranes may be made with pores having an average "characteristic dimension" of desired size. As used herein, "characteristic dimension" means the largest cross-sectional dimension of the pore in a plane perpendicular to the longitudinal axis of the pore.
Two or more arrays of pores having different properties of size, shape, orientation or distribution throughout the membrane also may be utilized. An advantage of using the membranes described herein is that the membrane may have, within a given array of pores, a pore size distribution of less than about 10 percent and sometimes less than 5 percent. As used herein, "pore size distribution" means the standard deviation of the average characteristic dimension.
The membranes of U.S. Ser. No. 07/804,294 may be made with pores having a variety of shapes, i.e., cross-sectional profile of the pore as the region of a plane perpendicular to longitudinal axis of the pores bounded by the pore walls. For instance, by selection of a suitable mask, pores may have a cross-sectional profile that is circular, ovate, square, rectangular, triangular, some other polygon, or irregular shapes. The orifices or pores may also be provided in a polka-dotted pattern with relatively large areas of densely spaced uniform pores separated by other relatively large areas where there are no pores. A membrane with a polka-dotted pattern is shown in FIG. 10. Referring to FIG. 10, the average dimension of the pores 300 is preferably between about 5 and 60 microns, most preferably between about 15 and 50 microns. The areas 310 containing the pores preferably have an average dimension of about 1 to 7 mm, more preferably 2 to 6 mm, and are separated by average distances of preferably about 3 to 8 mm, more preferably about 4 to 7 mm.
Membranes useful in the practice of the invention may be made from films of many types including polymeric materials and metals, such as metal foils. A particularly preferred material is polyethylene terephthalate. As discussed below, selection of the film material and selection of the boring means are dependent in part upon one another.
In general, ultraviolet boring techniques, e.g., ablation, may be used with polymeric films that contain unsaturated bonds. Membranes may be made using ultraviolet boring techniques with other polymers by incorporating ultraviolet absorbers therein to render the film ablative. Such absorbers are well known and may be readily selected and used by those with ordinary skill in the art.
Reactive ion etching techniques may also be used to make membranes of the invention from sheets of some types of polymers and metals.
An advantage to using the membranes described herein is that they may be made with pores having very low aspect ratios, e.g., 1:100, or up to very high aspect ratios, e.g., 60:1. As used herein, "aspect ratio" refers to the ratio of (1) the interior length of the longitudinal axis of the pores, i.e., the portion of the longitudinal axis which is within the volume of film vacated during boring of the pores, to (2) the average characteristic dimension of the pores. An advantage of the highly uniform pore size and narrow distribution of pore size which can be achieved in these membranes is that the resultant membranes can exhibit highly uniform characteristics.
In some embodiments, membranes may be made wherein the walls of the pores define frustum-like shapes. In such instances, each pore does not have a uniform cross-sectional area and the major portions of the walls of each pore are not substantially parallel to the pore's longitudinal axis. FIG. 8 illustrates membrane 210 comprising sheet 212 with pores 214 therein extending from first face 216 through second face 218. Major portions 220 of pores 214 are not parallel to each other or to longitudinal axis 222. As with other embodiments, however, at least 50 percent and preferably at least 75 percent of the length of the walls of each pore within a given array are straight. An advantage of such membranes is that they offer greater strength than do membranes with pores with similar minimum cross-sectional areas but having non-linear walls or wherein the dividers between adjacent pores are saddle-shaped. Some embodiments of such pores are sometimes referred to as being "Gaussian-shaped". Membranes with frustum-like pores exhibit less tendency to clog when the stream being filtered enters the face of the membrane having the smaller ends of the pores.
In some embodiments, membranes will comprise two or more arrays of different pores as described herein wherein the pores in different arrays have different characteristics. The arrays may be located at separate areas of the membrane or may be partially or totally superimposed.
An advantage of membranes of U.S. Ser. No. 07/804,294 is that the portions of the first face between pores, referred to herein as "land areas", and the land areas in the second face are substantially planar or flat. In a tangential flow of fluid across either face of membranes of the invention, the lack of surface saddle-like structures will allow for a better sweep of the fluid across the surface. Furthermore, membranes having saddle-like dividers between pores exhibit reduced flexural strength as compared to membranes of the invention.
c) forming an array of pores simultaneously in the film by application of directional means for boring through the mask; to yield the membrane with the array of pores therein.
Selection of means for boring will be based in part upon the nature of the mask used, the characteristics of the film from which the membrane is being made, and the features desired of the pores. Illustrative examples of means for boring include application of a collimated stream of reactive ions, plasma, or collimated energy beam (e.g., excimer laser or ultraviolet beam). In addition to being highly directional, the means for boring is preferably one which substantially does not deform the sheet outside the area being bored, i.e., one which substantially causes only localized removal of sheet material in the desired location and not in the surrounding land areas. For this reason, conventional chemical etching is typically not desired because it typically does not exhibit the desired directional boring. Preferably, by-products produced during boring, e.g., ablation by-products, are removed during boring such as by ventilation.
The foam sponge 16 comprises an open-cell foam material compatible with the liquid to be dispensed. Suitable open-cell foam sponge materials are prepared from thermoplastic materials such as polyethylene and polyurethane. Especially preferred open-cell foam materials are prepared from polyurethane thermoplastics.
By utilizing a permanently compression-set foam, the wicking and reservoiring properties of the foam sponge can be selected such that the liquid delivered through the porous layer 66 of the metering/bonding insert 72 wets the foam sponge 16 but does not drip from the sponge when the applicator is held with the sponge horizontal. The compression-set of the foam sponge can also be selected to affect the coating characteristics of the applicator. The greater the compression-set, the greater the amount of liquid that can be absorbed by the sponge material. Preferably, the foam sponge material is compressed by heat and pressure to about 1.5 to 10 times its original density, i.e., the compression-set ratio is between about 1.5 and 10. Most preferably, the compression-set ratio of the sponge is between about 2 and 4.
The porosity of the foam sponge 16 can also be selected to affect the wetting and coating characteristics of the applicator. Preferably, for surgical prep applications, the porosity of the foam sponge material is between 4 and 40 pores per linear centimeter, more preferably about 35 pores per linear centimeter. A particularly preferred open-cell foam sponge material is an elastomeric polyurethane foam having a compression-set ratio of between about 2 and 4 and a porosity of about 35 pores per linear centimeter, commercially available from Foamex, LP, East Providence, R.I. as "SIF-2.5-900Z".
The applicator of this invention is useful in dispensing liquids having viscosities at room temperature of less than about 10,000 cps, most preferably less than about 500 cps.
As noted above, the applicator is useful in dispensing antiseptic liquids to cleanse a surgical field prior to surgery. Examples of suitable antiseptic preparations include those described in U.S. Pat. No. 4,584,192 and those described in U.S. Pat. No. 4,542,012, the disclosures of which are incorporated herein by reference. Preferred antiseptic preparations are iodophoric skin tinctures, such as "Duraprep™ Surgical Solution," commercially available from 3M. The antiseptic liquid is delivered to the applicator foam sponge 16 which is gently rubbed over the surgical field to thereby cleanse it. The applicator can be actuated and handled easily without dripping the liquid onto other articles in the vicinity of the surgical field. The dripless feature and the ability to apply a controlled uniform coat allows application of the liquid to only the desired areas of the patient and also allows for quicker and more efficient use of a surgical facility due to elimination of the time needed to clean the facility of antiseptic prep that dripped and flowed off of the patient.
A stainless steel mask with uniformly distributed square apertures was placed in contact with a 25 micron (1 mil) thick poly(ethylene terephthalate) (i.e., "PET"), MYLAR™ film (from E.I. dupont de Nemours). The sides of the apertures were 15 microns in length with, according to the manufacturer, a standard deviation of about 10 percent and about 35 percent of the mask was open area.
The beam from a krypton/fluorine ("KrF") excimer laser producing 248 nanometer ("nm") radiation at a pulse frequency of 40 Hertz ("Hz") and pulse duration of 27 nanoseconds was projected through an iris and a series of lenses onto the mask. The iris was located about 30.5 centimeters ("cm") from the laser window and a few cm from the first lens. The lenses included (1) a 106.7 cm focal length converging lens located about 108 cm (42.5 inches) from the PET film plane, (2) a 20.3 cm focal length diverging lens located about 73 cm (283/4 inches) from the PET film plane, and (3) a 3.4 cm focal length cylindrical lens located about 4 cm (1.5 inches) from the film. These lenses are commercially available from ESCO Products Company and are made of CORNING™ 7490-UV, a material transparent to light at a wavelength of 248 nm, with AR-MgF2 antireflective coatings.
Ablation was accomplished by shadowing the mask pattern onto the PET film. The intensity of the laser radiation incident to the surface of the film was about 200 millijoules per centimeter2 ("mJ/cm2 ") with a beam shape at the surface of a rectangle about 3 millimeters (120 mils) wide and 15.2 cm (6 inches) long. The mask and PET film were moved in register across the middle 10.2 cm (4 inches) of the beam at a rate of about 0.25 cm/minute.
Scanning the mask/film combination yielded a 10.2 cm wide PET membrane with pores penetrating through the membrane. The axes of these pores were parallel to one another and perpendicular to the membrane surfaces.
The PET membrane was used as the porous layer 66 in an applicator generally as depicted in FIG. 2. The ampoule was filled with 26 milliliters of "Duraprep™ Surgical Solution". In two trials, the time required for the applicator to dispense 13 of the 26 milliliters of solution after breaking the ampoule was measured. Times of 15 and 16 seconds were observed.
In comparison, liquid dispensers as disclosed in U.S. Pat. No. 4,925,327 having substantially equal size as those above were observed to take from 15 to 60 seconds to dispense an equal amount of the same fluid.
A 9.6 millimeter thick sample of open cell polyurethane foam commercially available as "SIF-2-900Z" from Foamex, LP, of East Providence, R.I., was subjected to the following treatment. The surface of the foam was skinned by passing the foam under a heated (200° C.) bar. One surface of the foam contacted the heated bar and was melted. When the surface was melted, the foam cell structure collapsed creating a skin approximately 50 to 100 microns thick. This skin layer was subjected to the laser treatment using the mask and laser apparatus detailed in Example 1, except that the sides of the apertures in the mask were 53 microns in length. The foam was then used in an applicator for "Duraprep™ Surgical Solution" substantially as depicted in FIG. 2, except that no separate porous layer other than that integral to the modified foam was employed. The time required for the applicator to dispense 13 mls of fluid when tested as described in Example 1 was 15 seconds.
The superimposed pattern of two stainless steel masks was simultaneously replicated onto a 25 micron (1 mil) thick poly(ethylene terephthalate) (i.e., "PET"), MYLAR™ film (from E.I. dupont de Nemours). The first mask had square apertures uniformly distributed in a square array wherein the sides of the apertures were 38 microns in length with, according to the manufacturer, a standard deviation of about 10 percent and about 36 percent of the mask was open area. The first mask was placed in contact with the PET film. The second mask had round apertures of 4500 microns in diameter distributed in a center filled hexagonal array so sized that about 46 percent of the mask was open area. The second mask was placed over the exposed surface of the first mask. About 16 percent of the pattern exposed by the combined array was open area.
The beam from a krypton/fluorine ("KrF") excimer laser described in Example 1 was used to ablate by shadowing the mask pattern onto the PET film, as described in Example 1.
Scanning the mask/film combination yielded a 10.2 cm wide PET membrane with pores penetrating through the membrane. The axes of these pores were parallel to one another and perpendicular to the membrane surfaces. Where the edges of the round apertures of the second mask happened to overlap the edges of the square apertures of the first mask, some non-square openings in the PET membrane were created.
The membrane was then used as an applicator for "Duraprep™ Surgical Solution", substantially as depicted in FIG. 2. The average time required for 13 mls of fluid to flow through the foam of the applicator was tested as described in Example 2, and was 12.6 seconds.
Although specific embodiments of the invention have been described herein, it is not intended to limit the invention solely thereto, but to include all of the obvious variations and modifications within the spirit and scope of the appended claims.
(e) means associated with said hollow elongate member for rupturing the reservoir container after at least a portion of the container is pushed through the aperture in the deformable means; wherein the deformable means is a collar comprising a rim having a plurality of cantilevered beam elements projecting therefrom, the inside edges of the cantilevered beam elements defining the aperture through which at least a portion of the reservoir container may be pushed.
2. The article of claim 1 wherein the deformable means is adapted to elastically and plastically deflect to allow at least a portion of the reservoir container to pass through the aperture and contact the means for rupturing.
3. The article of claim 1 wherein the cantilevered beam elements project from the same edge of the rim of the collar.
4. The article of claim 1 wherein the means for limiting the axial displacement of the deformable means is a shoulder portion contained within the hollow elongate member, the cross-sectional diameter of the hollow elongate member at the shoulder portion being less than the cross-sectional diameter of the deformable means.
5. The article of claim 1 wherein said means for rupturing the reservoir container comprises a wedge projecting into the hollow elongate member and located between the deformable means and the first major orifice in the path of the reservoir container after at least a portion of it is pushed through the aperture in the deformable means.
6. The article of claim 1 further comprising a porous layer disposed over the first major orifice in the hollow elongate member, which porous layer is capable of regulating the flow of liquid therethrough to between about 0.1 and 15 milliliters per second.
7. The article of claim 1 further comprising a layer of sponge material disposed over the exterior of the first major orifice in the hollow elongate member.
8. The article of claim 1 further comprising means of maintaining atmospheric pressure within the hollow elongate member while the liquid is being dispensed.
(e) means associated with said hollow elongate member for rupturing the reservoir container after at least a portion of the container is pushed through the aperture in the deformable means; wherein the deformable means is a collar comprising a rim having a plurality of cantilevered beam elements projecting therefrom, the inside edges of the cantilevered beam elements defining the aperture through which at least a portion of the reservoir container may be pushed; and wherein the cap is comprised of an end wall, a side wall and a column axially projecting into the interior of the hollow elongate member from the interior surface of the end wall, the column having an axial hole which is open to the external surface of the cap, and wherein the column contacts the rupturable container and forces at least a portion of the container through the aperture in the deformable means when the cap is moved from the first to the second position.
US1221227A (en) * 1916-04-24 1917-04-03 Bauer & Black Surgical swab.
"A Fast, Easy, Long-Lasting I.V. Prep That Can Help Enhance Dressing Adhesion," Medical-Surgical Division, 3M Health Care, 3M Center, St. Paul, Minn., 1989 (Brochure).
"Duraprep™ Solution--Now Ideal for Outpatient, Office-Based and Other Minor Surgical Procedures," Medical-Surgical Products, 3M Health Care, 3M Center, St. Paul, Minn., 1991 (Brochure).
"Obsoletely? Absolutely!," Medical-Surgical Division, 3M Health Care Group, 3M Center, St. Paul, Minn., Mar. 1988 (Brochure). | 2019-04-24T18:44:51Z | https://patents.google.com/patent/US5435660A/en |
Ramifications of Brexit may be wide-spread and plentiful, yet difficult to predict accurately.
What has been clear is the confidence / uncertainty impact on the value of sterling – having just returned a family trip to Australia – whose currency has appreciated against the USD whilst sterling depreciates I can attest to the extent of the impact!
Whilst on leave I read some reactions regarding the difference in Microsoft’s price increases applied on-premises vs the cloud. By now, I would hope that Microsoft increasing sterling prices is not news to any reader, the following however is a view on the reasoning and scenarios of yours truly.
Earlier this year I authored a research note How Adopting Office 365 Will Impact Your Global Microsoft Licensing Strategy, to articulate how multinational organizations Microsoft licensing strategies can be impacted by choosing to adopt Office 365. Readers of that research purchasing for UK operations will likely have expected Microsoft’s price increase as sterling plunged last summer.
The first point reflects Microsoft use of pricing levers to incentivise cloud adoption in Europe. Moreover, Microsoft may be seeing more progress in European cloud services uptake than previously, and choose to establish USD price deltas more in keeping with on-premises pricing. Thus cloud subscription price increases outweigh on-premises. Consider also, flow through from USD price oriented hardware Microsoft acquires to run its datacenters and other imported costs that impacting Microsoft cloud services P&L.
Reference the second point, in recent years Euro, Norwegian Krone, Japanese Yen, Australian and Canadian Dollars Office 365 prices have all increased as exchange rates shifted, whilst sterling has not been subject to a currency based increase since July 2012. Actually, that last UK increase was somewhat offset in Office 365 terms by the price cut of 20% globally in March 2012.
It goes without saying that Microsoft report results in USD, so I won’t dwell on the basic justification following devaluation. What is perhaps less widely understood is the European currency context.
Following Brexit, sterling devaluation creates a much more significant delta to prices in Euro than that which our March research note identified. A 13% increase on premises now puts sterling prices within a single percent of on par with Euro pricing, although at a notable premium to USD prices.
During a session at our ITAM summits in September I referenced currency price impacts as one of a number of influences on future price increases for SaaS clients – on that note clients already committed to and dependent on Office 365 with upcoming renewals are likely the most exposed.
The 22% cloud increase shifts Sterling prices from a significant advantage to Euro pricing to circa 5% above Euro parity. Notably pre the Brexit devaluation Sterling prices were some 5% below Euro prices – one might conclude that Microsoft are comfortable with a plus/minus 5% European market scenario.
Microsoft’s timing of the announcement and calculation is intriguing. Exchange rates can be highly volatile, and may now be particularly so given the announcement the High Court ruling that UK parliamentary approval of brexit terms (and subsequent appeal) plus the imminent US election. Any point in time calculation may be subject to change. My calculations were based on rates prevailing today – November 7th.
UK DCs offset price increase negativity?
Having put in place a number of additional European datacenters, including UK facilities, a key data sovereignty and potential performance objection has been addressed, which may lead to greater cloud adoption locally and success for Microsoft in meeting cloud revenue objectives. It is of course unfortunate for organizations looking to commit to the new UK datacentre, which only recently went online, that price increases are now being introduced. Some Azure clients may be subject to additional price increases as Microsoft alters its volume discounting / pricing approach for Azure services.
The key question for clients is – What ought we do now?
Ahead of the July 2012 price increase a wave of business was brought forward and prices locked in. It may be tempting to do the same now in advance of December 31st.
Clients should consider the value of purchasing in sterling currently, particularly given cloud prices are lower than even USD equivalents. However be wary of bringing forward requirements too aggressively, as shelfware and unused subscriptions particularly may offset or outweigh any gain achieved (Gartner clients should see Cost Optimization — Save Money on Office Licensing If Benefits of Office 365 Can Wait).
Other considerations include continuing to acquire / renew as scheduled but in alternative currencies which may offer better value (subject to appropriate due diligence), and investigating plan B / exit scenarios should the cost increase be beyond budget tolerance.
Overall, organizations licensed perpetually on-premises with options to not renew maintenance thus avoiding a 13% increase are dramatically less exposed than organizations committed to subscriptions and a 22% increase, and highlight risks of using short term subscription pricing models with limited price protection.
Al Cipollone on What does an end to Adobe auditing and license compliance activity really mean? | 2019-04-21T16:10:40Z | https://blogs.gartner.com/stephen-white/2016/11/07/microsoft-brexit-and-that-price-increase/ |
We've been trying to find the words to best describe Courtney and Alan's wedding and as usual, we're tempted to say "let the pictures tell the story". But to be honest, we couldn't describe it in a better way than Courtney herself. This is what she wrote to us in one of her first mails: "It's really important for us to capture people and moments, as they happen. We haven't spent much (read: any) time on do-dahs and pretties, so you'll be hard pressed to find those kinds of details to shoot :) We're also not very big into posing, we're just going to love each other and our guests and hope that comes through in the pictures! The post-lunch time is supposed to be lazy and chilled - and that goes for you two as well!" The post-lunch time definitely was lazy - think that "post Sunday lunch feeling" on a lazy hot summers day - and ended with some of their guests either asleep or in a food-coma. And we're sure you'll agree that their love for each other and their guests does show in these pictures. Thank you for inviting us to photograph your wedding celebration, guys - we loved documenting this time for you. | 2019-04-21T00:53:24Z | https://welovepictures.co.za/alan-and-courtney/ |
All aboard the Haddam Swing Bridge Fall Special for a delightful all day fall foliage excursion, combining sightseeing, shopping, dining and culture in the towns of Haddam and East Haddam.
Board the historic Essex Steam Train for a late morning departure from Essex Station. The northbound trip skirts untouched woodlands, trestle bridges, tidal marshes and inlets as you revel in the bountiful Connecticut River Valley foliage. Pass through the quaint New England towns of Essex, Deep River and Chester on your journey to Goodspeed Station, serving Haddam and East Haddam. At Goodspeed Station, deboard the train for a 3+ hour visit to this historic river community composed of two towns – Haddam and East Haddam – joined together by the iconic 1913 East Haddam Swing Bridge. Shuttle buses (included) whisk you to your choice of quintessential shoreline stops that include dining, shopping, sightseeing, an eco-riverboat cruise, Eagle Landing State Park – a taste of everything that Haddam and East Haddam have to offer!
Candy, jewelry, gifts, home decor – can’t miss!
This excursion requires moderate walking distances to be covered.
All passengers board vintage coach train cars at Essex Station at 11:10 a.m. The train will depart Essex at 11:20 a.m. for a leisurely 55 minute train ride through the beautiful Lower Connecticut River Valley and along the Connecticut River to Haddam, Connecticut. After enjoying your day in Haddam & East Haddam, you will re-board the train to return to Essex Station at 4:30 p.m.
For guests’ convenience, we offer the following three options. Each option includes the round-trip train excursion.
11:20 a.m. – 12:15 p.m.
We suggest making advance reservation at one of the listed restaurants for 1:45 p.m.
leather chairs and Cash Beverage Service (on train only). | 2019-04-18T16:48:35Z | http://essexsteamtrain.com/seasonal-excursions/haddam-swing-bridge-fall-special/ |
2016 has been a stunning year for UK five-piece Inglorious. Their eponymous debut album was released through Frontiers Music in February. The album received widespread critical acclaim at press, multiple A lists at radio and a lauded performance on Vintage TV. The band are managed by QEDG (Yes, Asia) and booked by Steve Strange at X-Ray (live agent for Coldplay, Eminem and QOTSA).
The band toured across the world, with numerous high profile shows across the UK and Europe – including a show stopping performances at Download Festival 2016 and Ramblin’ Man Fair 2016, supports to Winery Dogs and The Dead Daisies, and culminating in support to Steel Panther’s European Arena tour in October 2016.
Set for release in 2017 the album is set to further push the rise of this remarkable band.
“Inglorious” is available ntwitter.com/weareingloriousow on Frontiers Music. | 2019-04-22T18:35:33Z | https://planetmosh.com/inglorious-new-studio-album-2017-uk-dates-novdec-2016/ |
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