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--- |
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license: mit |
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--- |
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--- |
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license: mit |
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language: |
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- en |
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pretty_name: ABX-CT-003 Collateral Sensitivity Pattern |
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tags: |
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- antibiotics |
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- combination-therapy |
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- collateral-sensitivity |
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- mic |
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- resistance |
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- tabular |
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task_categories: |
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- tabular-classification |
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size_categories: |
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- n<1k |
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--- |
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ABX-CT-003 Collateral Sensitivity Pattern |
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Purpose |
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Detect the paired pattern where resistance to Drug A coincides with increased sensitivity to Drug B. |
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Core pattern |
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- stress_index high |
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- Drug A MIC crosses a_resistant_cutoff_mg_L |
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- Drug B MIC drops at least 2x vs baseline and reaches a low floor |
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- Drug B drop occurs at the same or next timepoint in v1 |
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Files |
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- data/train.csv |
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- data/test.csv |
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- scorer.py |
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Schema |
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Each row is one timepoint in a within strain series. |
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Required columns |
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- row_id |
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- series_id |
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- timepoint_h |
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- organism |
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- strain_id |
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- drug_a |
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- drug_b |
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- stress_index |
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- baseline_mic_a_mg_L |
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- baseline_mic_b_mg_L |
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- mic_a_mg_L |
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- mic_b_mg_L |
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- a_resistant_cutoff_mg_L |
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- b_susceptible_floor_mg_L |
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- b_sensitivity_fold_change |
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- media |
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- assay_method |
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- source_type |
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- collateral_sensitivity_signal |
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- earliest_collateral_sensitivity |
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Labels |
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- collateral_sensitivity_signal |
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- 1 for rows at or after the first detected collateral sensitivity row |
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- earliest_collateral_sensitivity |
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- 1 only for the first detected row in that series |
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Scorer logic in v1 |
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- baseline Drug A must be below resistant cutoff |
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- find first time Drug A crosses resistant cutoff under stress |
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- collateral sensitivity triggers if Drug B at the same or next timepoint |
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- drops by at least 2x vs baseline |
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- reaches b_susceptible_floor_mg_L or lower |
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Evaluation |
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Run |
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- python scorer.py --path data/test.csv |
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