| | --- |
| | license: mit |
| | language: |
| | - en |
| | pretty_name: ABX-HT-007 Allergic Sensitization Pattern |
| | tags: |
| | - antibiotics |
| | - toxicity |
| | - allergy |
| | - hypersensitivity |
| | - immune |
| | - eosinophils |
| | - tryptase |
| | - tabular |
| | task_categories: |
| | - tabular-classification |
| | size_categories: |
| | - n<1k |
| | --- |
| | |
| | ABX-HT-007 Allergic Sensitization Pattern |
| |
|
| | Purpose |
| |
|
| | Detect early allergic sensitization when immune response markers stop tracking treatment duration before hypersensitivity events. |
| |
|
| | Core pattern |
| |
|
| | - host_stress_index high |
| | - duration_exposure_index high |
| | - immune_coherence_index drops |
| | - eos_rise_vs_expected or tryptase_rise_vs_expected stays high |
| | - later_hypersensitivity_flag appears |
| |
|
| | Files |
| |
|
| | - data/train.csv |
| | - data/test.csv |
| | - scorer.py |
| |
|
| | Schema |
| |
|
| | Each row is one timepoint in a within series treatment course. |
| |
|
| | Required columns |
| |
|
| | - row_id |
| | - series_id |
| | - treatment_day |
| | - host_model |
| | - drug |
| | - duration_exposure_index |
| | - total_dose_mg |
| | - expected_total_dose_mg |
| | - dose_deviation |
| | - eos_percent |
| | - expected_eos_percent |
| | - eos_rise_vs_expected |
| | - tryptase_ng_mL |
| | - expected_tryptase_ng_mL |
| | - tryptase_rise_vs_expected |
| | - immune_coherence_index |
| | - host_stress_index |
| | - later_hypersensitivity_flag |
| | - assay_method |
| | - source_type |
| | - allergic_sensitization_signal |
| | - earliest_allergic_sensitization |
| |
|
| | Labels |
| |
|
| | - allergic_sensitization_signal |
| | - 1 for rows at or after first confirmed sensitization onset |
| |
|
| | - earliest_allergic_sensitization |
| | - 1 only for the first onset row in that series |
| |
|
| | Scorer logic in v1 |
| |
|
| | - exclude series with high baseline eosinophils |
| | - candidate onset point |
| | - host_stress_index at least 0.80 |
| | - duration_exposure_index at least 0.80 |
| | - immune_coherence_index at most 0.40 |
| | - eos_rise_vs_expected at least 3.0 or tryptase_rise_vs_expected at least 5.0 |
| | - for two consecutive points |
| | - ignore one point eosinophil spike then recovery artifacts |
| | - confirmation |
| | - later_hypersensitivity_flag equals 1 later in series |
| |
|
| | Evaluation |
| |
|
| | Run |
| |
|
| | - python scorer.py --path data/test.csv |
| |
|
