| | --- |
| | language: |
| | - en |
| | license: mit |
| | pretty_name: AlphaFold Interface Coherence Baseline Mapping v0.1 |
| | dataset_name: alphafold-interface-coherence-baseline-mapping-v0.1 |
| | tags: |
| | - clarusc64 |
| | - alphafold |
| | - alphafold-multimer |
| | - protein-protein-interactions |
| | - interface-stability |
| | task_categories: |
| | - tabular-regression |
| | size_categories: |
| | - 1K<n<10K |
| | configs: |
| | - config_name: default |
| | data_files: |
| | - split: train |
| | path: data/train.csv |
| | - split: test |
| | path: data/test.csv |
| | --- |
| | |
| | ## What this dataset tests |
| |
|
| | Whether a model can construct |
| | a stable baseline map |
| | of protein–protein interface coherence. |
| |
|
| | This is the intact coupling state. |
| | No stress applied. |
| | No mutation applied. |
| |
|
| | The target is the interface basin. |
| |
|
| | ## Inputs |
| |
|
| | interface_residue_count |
| | contact_density |
| | baseline_deltaG_bind |
| | baseline_kd_nM |
| | contact_stability_score |
| | hotspot_integrity_score |
| | allosteric_cross_interface_score |
| |
|
| | ## Required outputs |
| |
|
| | interface_coherence_score |
| | signal_paths |
| | baseline_failure_margin |
| | |
| | ## Task |
| | |
| | Given baseline interface metrics |
| | predict: |
| | |
| | - interface coherence score |
| | - cross-interface signal paths |
| | - the failure margin before instability |
| | |
| | ## Use cases |
| | |
| | Biologic complex design |
| | Synthetic pathway assembly |
| | Protein engineering QC |
| | Baseline maps for stress testing |
| | |
