task
stringclasses
5 values
input
stringlengths
89
339
functional_group
### Instruction: Does the molecule contain a hydroxyl group? CN(CC[C@H]1CCCCO1)C(=O)[C@H]1C=C(Cn2ccc3ccccc32)N=N1 ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. c1c(Cl)c(ccc1Cl)[C@H]1[C@H]2CC=C[C@@H]2c2cc(ccc2N1)S(=O)(=O)NC[C@H]1CCCO1 ### Response: O=S(=O)(NC[C@H]1CCCO1)c1ccc2c(c1)[C@H]1C=CC[C@@H]1[C@H](c1ccc(Cl)cc1Cl)N2
canonicalization
### Instruction: Canonicalize the following SMILES string. O=C(c1cccc(OC(C)C)c1)NC(=S)Nc1cccc2c1C(N(c1ccccc1)C2=O)=O ### Response: CC(C)Oc1cccc(C(=O)NC(=S)Nc2cccc3c2C(=O)N(c2ccccc2)C3=O)c1
functional_group
### Instruction: Does the molecule contain a phenol group? Cc1cc(C)n2nc(C)c(C(=O)Nc3cc([N+](=O)[O-])ccc3O)c2n1 ### Response: Yes
ring_counting
### Instruction: Count the five-membered rings in the following molecule. COCCOc1ccc(NC(=O)c2nc(C)n[nH]2)cc1 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@@H]1CCCN(C(=O)C(=O)Nc2ccc([S@@](=O)C(F)(F)F)cc2)C1 ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [16*]c1ccc(Br)cc1OC Fragment 2: [8*][C@H]([NH3+])C(=O)[O-] ### Response: COc1cc(Br)ccc1[C@H]([NH3+])C(=O)[O-]
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCc1cccc(C)c1NC(=O)N1CCN(C(=O)C(=O)NC(C)C)CC1 ### Response: 3
canonicalization
### Instruction: Canonicalize the following SMILES string. [nH]1c2ccc(C(NC[C@H](N3CCOCC3)C(CC)CC)=O)cc2nc1 ### Response: CCC(CC)[C@H](CNC(=O)c1ccc2[nH]cnc2c1)N1CCOCC1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [3*]OCCCC#N Fragment 2: [3*]Oc1cccc(N[5*])c1 ### Response: Cn1cc(C(=O)Nc2cccc(OCCCC#N)c2)c(-c2ccccc2)n1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(C)c(sc(c1C)NC(=O)C[NH+]1CCC[C@H]1CN1CCOCC1)C ### Response: Cc1sc(NC(=O)C[NH+]2CCC[C@H]2CN2CCOCC2)c(C)c1C
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC(=O)C[C@@H]1CCCN1C(=O)c1ccc2c(c1)COC2 ### Response: 3
canonicalization
### Instruction: Canonicalize the following SMILES string. n1oc(nc1-c1cscc1)C[NH+]1CCN(CC1)C(=O)c1ccc(OCc2c(C)noc2C)cc1 ### Response: Cc1noc(C)c1COc1ccc(C(=O)N2CC[NH+](Cc3nc(-c4ccsc4)no3)CC2)cc1
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? c1ccc([C@H]2CN/C(=[NH+]\[C@@H]3C[NH+]4CCC3CC4)S2)cc1 ### Response: Yes
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? C[C@H]1CC(=O)Nc2ccccc2N1C(=O)CSc1nc(C(C)(C)C)nc2c1c(=O)n(C)c(=O)n2C ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. C(SCc1nc(CC)on1)c1nsc(n1)N(C)C ### Response: CCc1nc(CSCc2nsc(N(C)C)n2)no1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1cc(C(CCCOC)(CO)CO)ccc1C ### Response: COCCCC(CO)(CO)c1ccc(C)cc1
functional_group
### Instruction: Does the molecule contain a halide group? CCc1cccc(C)c1NC(=O)CN1C(=O)C(C)=C(c2ccc(F)cc2)S1(=O)=O ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]NCc1ccccc1C Fragment 2: [1*]C(=O)c1cnn2cc(Br)cnc12 ### Response: Cc1ccccc1CNC(=O)c1cnn2cc(Br)cnc12
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C([O-])c1cc(F)cc(-c2cc3ccccc3s2)c1 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1cc2OCC(=Cc2cc1)C(Nc1cc(ccc1OC)C)=O ### Response: COc1ccc(C)cc1NC(=O)C1=Cc2ccccc2OC1
functional_group
### Instruction: Does the molecule contain a halide group? C[C@H]1CCC[C@@H](N(C)C(=O)c2ccccc2OC[C@@H]2CCCO2)C1 ### Response: No
functional_group
### Instruction: Does the molecule contain a amide group? CCc1nnc(NC(=O)c2cccc(C)c2C)s1 ### Response: Yes
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Cn1cc[nH+]c1N1CCN(CC(=O)NC2CCCCC2)CC1 ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]CC(C)C[4*] Fragment 2: [1*]C(=O)N([5*])C ### Response: CCN1CC[NH+](C[C@H](C)CNC(=O)N(C)C[C@@H](C)O)CC1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@H](S[C@H]1N=C(Cl)N=C2N=CN=C21)C(=O)[O-] ### Response: 3
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(c(cc2c(C(=O)N(CC(=O)NCc3ccccc3)C2=O)c1)Cl)Cl ### Response: O=C(CN1C(=O)c2cc(Cl)c(Cl)cc2C1=O)NCc1ccccc1
functional_group
### Instruction: Does the molecule contain a hydroxyl group? CC1=C(C)C[C@@H](C(=O)N[C@@H](C)CCc2ccccc2)[C@H](C(=O)[O-])C1 ### Response: No
ring_counting
### Instruction: Count the five-membered rings in the following molecule. O=C(NCCc1cnn(-c2ccccc2)c1)c1ccc(F)cc1F ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)CC[8*] Fragment 2: [4*][C@H]([8*])CN[5*] ### Response: Cc1cc2nc(C)c(CCC(=O)NC[C@@H](c3ccccc3)N3CCOCC3)c(C)n2n1
canonicalization
### Instruction: Canonicalize the following SMILES string. OC1(CCCC1)CC(=O)N(CCCc1ccccc1)C ### Response: CN(CCCc1ccccc1)C(=O)CC1(O)CCCC1
canonicalization
### Instruction: Canonicalize the following SMILES string. O=C(N1CCN(CC1)C([C@H]1[C@@H](C)C1)=O)N[C@H](C(C)(C)C[NH+](C)C)C ### Response: C[C@H](NC(=O)N1CCN(C(=O)[C@@H]2C[C@@H]2C)CC1)C(C)(C)C[NH+](C)C
canonicalization
### Instruction: Canonicalize the following SMILES string. c1c(NC(NCCC(=O)N2CCCC2)=O)ccc(c1Cl)C(=O)N ### Response: NC(=O)c1ccc(NC(=O)NCCC(=O)N2CCCC2)cc1Cl
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC[C@@H](CNC(=O)N1CCC(CO)CC1)Oc1cccc(C(F)(F)F)c1 ### Response: 4
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [8*][C@@H](C[NH3+])S[11*] Fragment 2: [4*][C@H](C)CCO ### Response: Cc1cccc([C@@H](C[NH3+])S[C@H](C)CCO)c1
functional_group
### Instruction: Does the molecule contain a ketone group? Cc1ccc2[nH]c(SCC(=O)c3ccc(O)c(O)c3)nc2c1 ### Response: Yes
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? C[C@H]1CCC[C@@H](CNc2ccc(C(=O)NCCCO)cc2)C1 ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. CN1[C@H]([C@H]([NH3+])Cc2n(CC)ncn2)C[NH+](C)CC1 ### Response: CCn1ncnc1C[C@@H]([NH3+])[C@@H]1C[NH+](C)CCN1C
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]Cc1ccc(CO)o1 Fragment 2: [5*][NH+]1CCCC[C@H]1C ### Response: C[C@@H]1CCCC[NH+]1CCC1CC[NH+](Cc2ccc(CO)o2)CC1
functional_group
### Instruction: Does the molecule contain a nitro group? Cc1ccc(S(=O)(=O)N2CCN(C(=O)Cn3c(C(F)(F)F)nc4ccccc43)CC2)cc1 ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. C(N1[C@](O)(C(F)(F)F)CC(=N1)C)(c1ccc(Cn2c(c(Br)c(C)n2)C)cc1)=O ### Response: CC1=NN(C(=O)c2ccc(Cn3nc(C)c(Br)c3C)cc2)[C@](O)(C(F)(F)F)C1
functional_group
### Instruction: Does the molecule contain a nitro group? O=C(NCc1cccc([N+](=O)[O-])c1)N1CCCCCC1 ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]Nc1ccc(N([5*])C)c(F)c1 Fragment 2: [5*]NCc1cn2ccsc2n1 ### Response: CC(C)N(C)c1ccc(NC(=O)NCc2cn3ccsc3n2)cc1F
ring_counting
### Instruction: Count the six-membered rings in the following molecule. O=C1CSC2=NC3=C(CCCC3=C3SCCS3)[C@H](c3ccccc3)N12 ### Response: 3
canonicalization
### Instruction: Canonicalize the following SMILES string. c1c([C@@H]([NH3+])[C@H]2CSCCS2)cc(C)c(F)c1 ### Response: Cc1cc([C@@H]([NH3+])[C@H]2CSCCS2)ccc1F
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)c1oc2ccccc2c1CO[3*] Fragment 2: [4*]C[C@H]1CCCO1 ### Response: O=C(c1oc2ccccc2c1COc1ccccc1)N1CC[NH+](C[C@H]2CCCO2)CC1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1cccc(NC(=O)CN(C)C(=O)COc2ccc(C#N)cc2)c1C ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [13*][C@@H]1C=C(c2ccccc2)N=N1 Fragment 2: [6*]C(=O)N/N=C/c1cc(Br)cc(Br)c1OC ### Response: COc1c(Br)cc(Br)cc1/C=N/NC(=O)[C@@H]1C=C(c2ccccc2)N=N1
functional_group
### Instruction: Does the molecule contain a nitrile group? C[C@@H](Sc1nnc(-c2ccccc2Cl)n1C)C(=O)NC1CCCCC1 ### Response: No
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N1CCN([5*])CC1 Fragment 2: [1*]C(=O)CC[8*] ### Response: O=C(CCC1CCOCC1)N1CCN(c2ncccc2F)CC1
canonicalization
### Instruction: Canonicalize the following SMILES string. CC1([C@@](C[C@H]1NC(C(Nc1cc(F)ccc1OC)=O)=O)(C)OC)C ### Response: COc1ccc(F)cc1NC(=O)C(=O)N[C@@H]1C[C@](C)(OC)C1(C)C
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? Cc1nn2c(nnc3c(=O)n(CCCN4CCOCC4)ccc32)c1-c1ccc(Cl)cc1 ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(OC)cc2OC[C@H](Cc2cc1)[NH2+][C@@H](CC(=O)Nc1ccc(OC)cc1)C ### Response: COc1ccc(NC(=O)C[C@@H](C)[NH2+][C@@H]2COc3cc(OC)ccc3C2)cc1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CCCOc1ncccc1CNC(=O)Cc1cccc(F)c1F ### Response: 0
canonicalization
### Instruction: Canonicalize the following SMILES string. C1C2(CCC2)[C@H]1C(=O)N1Cc2n(CCC1)nc(-c1[nH]c3cc(F)ccc3n1)c2 ### Response: O=C([C@H]1CC12CCC2)N1CCCn2nc(-c3nc4ccc(F)cc4[nH]3)cc2C1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCN(C(C)=O)c1nc(CN2C[C@@H](C)O[C@H](c3ccccc3)C2)cs1 ### Response: 2
ring_counting
### Instruction: Count the six-membered rings in the following molecule. C[C@H](O)[C@H](C)SCC(=O)Nc1ccc(Cl)cn1 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? NNc1ccc(F)c(C(F)(F)F)c1 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]CCCOC Fragment 2: [5*]Nc1nc(=S)[nH]c2ccccc12 ### Response: COCCCNc1nc(=S)[nH]c2ccccc12
canonicalization
### Instruction: Canonicalize the following SMILES string. c1cc(ccc1OCC(C)C)C(NCC[NH+]1CCCCC1)=O ### Response: CC(C)COc1ccc(C(=O)NCC[NH+]2CCCCC2)cc1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. C=CCc1ccccc1OCc1nnc(NC(=O)Nc2ccc(Cl)cc2)s1 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [8*]C[C@@H](C)O Fragment 2: [10*]N1CC(=O)N2CCC[C@@H]2C1=O ### Response: C[C@@H](O)CN1CC(=O)N2CCC[C@@H]2C1=O
functional_group
### Instruction: Does the molecule contain a ketone group? COc1ccc([N+](=O)[O-])cc1CN1CCC[NH+](CC(=O)N2CCCC2)CC1 ### Response: No
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C(NCc1ccc(-n2cncn2)nc1)N1CCC[C@@H]1c1ccccc1 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. CC/C(C[NH2+]CCC)=C/c1oc(cc1)-c1c(F)cccc1 ### Response: CCC[NH2+]C/C(=C\c1ccc(-c2ccccc2F)o1)CC
canonicalization
### Instruction: Canonicalize the following SMILES string. c1c(c(Cl)ncc1)C(N[C@H](C(=O)N)C(C)(C)C)=O ### Response: CC(C)(C)[C@H](NC(=O)c1cccnc1Cl)C(N)=O
canonicalization
### Instruction: Canonicalize the following SMILES string. C1CN([C@@H](C)CC1)C(=O)c1cc(nc2c1cnn2CC)-c1ccccc1 ### Response: CCn1ncc2c(C(=O)N3CCCC[C@@H]3C)cc(-c3ccccc3)nc21
ring_counting
### Instruction: Count the five-membered rings in the following molecule. COC[C@](C)(NC(=O)NCc1cc(=O)[nH]c2ccccc12)c1ccccc1 ### Response: 0
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? CCn1c(SCc2ccccc2C)nc2ccccc2c1=O ### Response: Yes
ring_counting
### Instruction: Count the six-membered rings in the following molecule. O=S(=O)(Nc1ccc(-c2cc3ccccc3[nH]2)cc1)c1ccc(F)cc1 ### Response: 3
canonicalization
### Instruction: Canonicalize the following SMILES string. N1(C(c2cnc3n(cc(C)s3)c2=O)=O)[C@@H](C)CC[C@H](C)C1 ### Response: Cc1cn2c(=O)c(C(=O)N3C[C@@H](C)CC[C@@H]3C)cnc2s1
functional_group
### Instruction: Does the molecule contain a ether group? COCCN1C[C@H](C(=O)NCc2ccccn2)CC1=O ### Response: Yes
functional_group
### Instruction: Does the molecule contain a ether group? C[C@H](CS(C)(=O)=O)NC(=O)C1(c2ccc(F)cc2F)CCOCC1 ### Response: Yes
ring_counting
### Instruction: Count the six-membered rings in the following molecule. COc1ccc([C@H]2CCCN2C(=O)/C=C/c2ccc(Cl)c([N+](=O)[O-])c2)cc1 ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. c1cc2nc(C(F)(F)F)n(CCNC(=O)c3ccc(c(c3)C)C)c2nc1 ### Response: Cc1ccc(C(=O)NCCn2c(C(F)(F)F)nc3cccnc32)cc1C
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Cc1ccccc1[C@@H]1CCCN1C(=O)c1cnn2ccn(C)c12 ### Response: 1
functional_group
### Instruction: Does the molecule contain a ether group? CCCc1c([O-])[nH]c([C@H]2CN(CC)CCO2)nc1=O ### Response: Yes
functional_group
### Instruction: Does the molecule contain a nitrile group? N#CCN(C(=O)CSCc1ccc(C#N)cc1)C1CCCC1 ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(OC)ccc(cc1)S(=O)(=O)CC(Nc1sc2cc(OCC)ccc2n1)=O ### Response: CCOc1ccc2nc(NC(=O)CS(=O)(=O)c3ccc(OC)cc3)sc2c1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]NC(C)(C)C Fragment 2: [4*]CC(=O)N[5*] ### Response: CC(C)(C)NC(=O)NC(=O)CSc1nc(-c2ccncc2)n[nH]1
functional_group
### Instruction: Does the molecule contain a ether group? C[C@@H](Oc1cccc(Cl)c1)C(=O)Nc1cccc(S(=O)(=O)N(C)C)c1 ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(NC([C@@H](C)[n+]2ccc(C(C)=O)cc2)=O)ccc(c(c1)Cl)Cl ### Response: CC(=O)c1cc[n+]([C@H](C)C(=O)Nc2ccc(Cl)c(Cl)c2)cc1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [16*]c1ccccc1 Fragment 2: [1*]C(=O)[C@@H](N[5*])C(C)C ### Response: CC(C)[C@H](NC(=O)c1cc2cc(Cl)ccc2n1C)C(=O)N[C@@H](C(=O)[O-])c1ccccc1
functional_group
### Instruction: Does the molecule contain a thiol group? O=C(CC[S@@](=O)c1ccccc1)NC(=O)NCC(F)(F)F ### Response: No
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? CC(=O)N[C@H]1C(=O)N=C(SCC(=O)Nc2cccc3ccccc23)NC1=O ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COc1cc(/C=C/c2cc(C(=O)[O-])c3ccccc3n2)ccc1OCC(=O)[O-] ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. O=C(Nc1n(nc(c1)-c1cccs1)-c1nc(c(C)c([nH]1)=O)C)COCC ### Response: CCOCC(=O)Nc1cc(-c2cccs2)nn1-c1nc(C)c(C)c(=O)[nH]1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*][NH+](C)C Fragment 2: [4*]C[C@@H]([8*])NC ### Response: CN[C@@H](C[NH+](C)C)c1ccc(C)nc1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COC(=O)c1ccc(Cl)cc1NC(=O)[C@@H]1Cc2ccccc2C(=O)O1 ### Response: 1
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? COc1ccc(OCCNC(=O)c2ccc(N3CCOCC3)cc2)cc1 ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C#CCn1/c(=N/C(=O)[C@@H]2CCCCN2S(C)(=O)=O)sc2cc(Cl)ccc21 ### Response: 3
ring_counting
### Instruction: Count the six-membered rings in the following molecule. C[C@@H](NC(=O)Nc1ccccc1CN1CCc2ccccc21)[C@@H]1CCCO1 ### Response: 2
ring_counting
### Instruction: Count the six-membered rings in the following molecule. O=C(NC(=S)Nc1ccccn1)c1cc2ccccc2o1 ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]CC=C Fragment 2: [5*][NH2+]CC=C ### Response: C=CC[NH2+]CC(=O)N[C@H](C)c1c(C)noc1C
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N1C[C@@H]([13*])[NH2+]CC1(C)C Fragment 2: [8*]C(C)C ### Response: CC(C)[C@@H]1CN(Cc2ccc(O)cc2)C(C)(C)C[NH2+]1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CC1CC(NC(=O)C2(c3ccc(F)cc3F)CCCC2)C1 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [14*]c1ccco1 Fragment 2: [4*]Cc1cc(OC)c2c(c1)OCCO2 ### Response: COc1cc(C[NH2+]C[C@@H](c2ccco2)N(C)C)cc2c1OCCO2
functional_group
### Instruction: Does the molecule contain a carboxyl group? CC(C)[C@](C)(O)CNC(=O)N[C@@H](C)CS(C)(=O)=O ### Response: No
functional_group
### Instruction: Does the molecule contain a carboxyl group? C[NH+](C)[C@H]1CC[C@H](NC(=O)NNC(=O)Cc2ccc3ccccc3c2)C1 ### Response: No
functional_group
### Instruction: Does the molecule contain a ketone group? CN(CCOCC1CC1)c1ccc2nnc(C(F)(F)F)n2n1 ### Response: No