task
stringclasses
5 values
input
stringlengths
89
339
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? N#CN(CCc1ccccc1)c1ccc(F)c([N+](=O)[O-])c1 ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1nc(CN(C)C(=O)[C@@H]2CC[NH2+][C@H]2C)n[nH]1 ### Response: 1
functional_group
### Instruction: Does the molecule contain a nitrile group? CCCCNC(=O)CCc1c(C)nc2c3ccccc3nn2c1C ### Response: No
functional_group
### Instruction: Does the molecule contain a amide group? O=C([C@H]1CC(Cc2cccc(Cl)c2)=NO1)N1CCN(c2ncc3ccccc3n2)CC1 ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@@H](c1ccc(C(F)(F)F)cc1)[S@@](=O)Cc1cn2ccccc2n1 ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. C(C)n1c(c(cc1C)C(CN1C(=O)N[C@@](c2ccc(cc2)C#N)(C1=O)C)=O)C ### Response: CCn1c(C)cc(C(=O)CN2C(=O)N[C@@](C)(c3ccc(C#N)cc3)C2=O)c1C
ring_counting
### Instruction: Count the six-membered rings in the following molecule. O=S(=O)(Oc1cccnc1Cl)c1ccc(Cl)cc1 ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@@H](Sc1nc2ccccc2s1)C(=O)NCC(C)(C)c1ccncc1 ### Response: 3
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [14*]c1nc2ccc(Br)cc2c(=O)[nH]1 Fragment 2: [16*]c1cccc(C)c1 ### Response: Cc1cccc(-c2nc3ccc(Br)cc3c(=O)[nH]2)c1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1c(ccc(c1)F)S(=O)(N1CC(C1)C(=O)[O-])=O ### Response: O=C([O-])C1CN(S(=O)(=O)c2ccc(F)cc2)C1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. O=C(Nc1cccnc1)c1ccc(NC(=O)c2ncn(-c3ccccc3)n2)cc1 ### Response: 3
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC[C@](C)(CCO)NC(=O)N[C@H]1CCCC[C@@H]1OC1CCCC1 ### Response: 5
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [12*]S(=O)(=O)c1ccc([16*])cc1 Fragment 2: [5*]NC(=[NH2+])N[5*] ### Response: Cc1cc(C)nc(NC(=[NH2+])Nc2ccc(S(=O)(=O)Nc3nccc(C)n3)cc2)n1
functional_group
### Instruction: Does the molecule contain a amide group? O=C(CC[C@@H]1CCC[NH+](Cc2cccc3cccnc23)C1)N1CCCC1 ### Response: Yes
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? CC[C@@H](C)NS(=O)(=O)Cc1cccc(NC(=O)[C@H]2CCOC2)c1 ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC1(C)CN(C(=O)c2ccc(Cl)cn2)CC[S@]1=O ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1c2c(cc(c1)OC)=[NH+]C(=O)[C@@H](CCNS(=O)(=O)c1ccc(OC)cc1)C=2 ### Response: COc1ccc(S(=O)(=O)NCC[C@H]2C=c3ccc(OC)cc3=[NH+]C2=O)cc1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@@H](O)CCCCn1c(=O)c2c(ncn2C)n(C)c1=O ### Response: 6
ring_counting
### Instruction: Count the six-membered rings in the following molecule. COc1ccc([C@H](C)NS(=O)(=O)c2ccc3c(c2)CCO3)cc1F ### Response: 2
ring_counting
### Instruction: Count the six-membered rings in the following molecule. C[C@@H]1Cc2ccccc2N1CC(=O)Nc1cc(C(F)(F)F)ccc1-n1cncn1 ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]Nc1ccc(N[5*])cc1 Fragment 2: [5*]Nc1ccc([16*])cc1 ### Response: Cc1ccnc2nc(C(=O)Nc3ccc(Nc4ccccc4)cc3)nn12
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*][NH+]1CCC(CC)(CC)CC1 Fragment 2: [4*]CCCCS ### Response: CCC1(CC)CC[NH+](CCCCS)CC1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCCNS(=O)(=O)c1ccc2c(c1)[C@H]1C=CC[C@@H]1[C@H](c1ccc(SC)cc1)N2 ### Response: 3
canonicalization
### Instruction: Canonicalize the following SMILES string. c1cc(c([C@H](CC(N2Cc3c(ccc([N+]([O-])=O)c3)CC2)=O)C)cc1)C ### Response: Cc1ccccc1[C@@H](C)CC(=O)N1CCc2ccc([N+](=O)[O-])cc2C1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C(NCCCCN1CCOCC1)C(=O)Nc1cccc(F)c1 ### Response: 4
functional_group
### Instruction: Does the molecule contain a amide group? CC(C)(C)OC(=O)N1CC[C@H](C(=O)N2CC[C@H]([NH+]3CCCC3)C2)C1 ### Response: Yes
ring_counting
### Instruction: Count the six-membered rings in the following molecule. COc1ncccc1CNC(=O)NC1CCC([NH+]2CCCCC2)CC1 ### Response: 3
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(n(C)nc(-c2ccccc2)c1)C(NCC1(CO)CC1)=O ### Response: Cn1nc(-c2ccccc2)cc1C(=O)NCC1(CO)CC1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COc1ccccc1CC(=O)Nc1cc(C)ccc1NC(=O)C1CCCCC1 ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [10*]N1CCCC1=O Fragment 2: [1*]C(=O)CC[8*] ### Response: Cc1sc(NC(=O)CCN2CCCC2=O)c(C(N)=O)c1C
canonicalization
### Instruction: Canonicalize the following SMILES string. c1c(ccc(c1)Cl)OCc1nc([nH]n1)SCCC ### Response: CCCSc1nc(COc2ccc(Cl)cc2)n[nH]1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CS(=O)(=O)NC[C@H]1O[C@@H](CC(=O)N2CCN(c3cccc[nH+]3)CC2)[C@H](O)[C@@H]1O ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. c1c(c(S(=O)(=O)N2CCOCC2)cc2n(C)c(=O)c(n(c12)C)=O)C ### Response: Cc1cc2c(cc1S(=O)(=O)N1CCOCC1)n(C)c(=O)c(=O)n2C
functional_group
### Instruction: Does the molecule contain a aldehyde group? COc1cccc(OC)c1OC1CC[NH+](Cc2ccc([C@H]3C[C@@H]3C)o2)CC1 ### Response: No
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)C1=C(N)OC2=C(COC(C)=C2)[C@H]1[15*] Fragment 2: [3*]OCC ### Response: CCOC(=O)C1=C(N)OC2=C(COC(C)=C2)[C@H]1c1ccc(Cl)cc1Cl
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]Cc1ccc([16*])cn1 Fragment 2: [5*]N[C@H]1CCC(=O)N(C)C1=O ### Response: CN1C(=O)CC[C@H](NCc2ccc(C(=O)[O-])cn2)C1=O
canonicalization
### Instruction: Canonicalize the following SMILES string. c1c(ncnc1C)SCCC(Nc1nc(-c2ccc(cc2)C)cs1)=O ### Response: Cc1ccc(-c2csc(NC(=O)CCSc3cc(C)ncn3)n2)cc1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(ccccc1OC)C(=O)NCS ### Response: COc1ccccc1C(=O)NCS
canonicalization
### Instruction: Canonicalize the following SMILES string. C1CN(CCC1)c1c2c(n(c(c2C)C)-c2ccccc2)nc(n1)C(=O)Nc1ccc(F)cc1 ### Response: Cc1c(C)n(-c2ccccc2)c2nc(C(=O)Nc3ccc(F)cc3)nc(N3CCCCC3)c12
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CCO[C@H](C)n1cc(I)cn1 ### Response: 0
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]CC([6*])=O Fragment 2: [15*]C1CC1 ### Response: Cc1cc(C(=O)CN(C)S(=O)(=O)c2ccc(F)cc2)c(C)n1C1CC1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N1CC[C@H](C(N)=O)c2ccccc21 Fragment 2: [15*][C@H]1CCC[C@H](C)C1 ### Response: C[C@H]1CCC[C@H](OCC(=O)N2CC[C@H](C(N)=O)c3ccccc32)C1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1c(c(cc(N[C@H](C)C[NH+]2CCCCC2)[nH+]1)C)N ### Response: Cc1cc(N[C@H](C)C[NH+]2CCCCC2)[nH+]cc1N
canonicalization
### Instruction: Canonicalize the following SMILES string. [NH2+](C)[C@](C([O-])=O)(C)CCSc1ccncc1 ### Response: C[NH2+][C@](C)(CCSc1ccncc1)C(=O)[O-]
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC[C@@H](C)NC(=O)c1ccc(S(=O)(=O)NC(C)(C)C)cc1 ### Response: 4
canonicalization
### Instruction: Canonicalize the following SMILES string. c1cc(OCC(Nc2c(cc(Br)cc2)C(C)C)=O)ccc1[N+](=O)[O-] ### Response: CC(C)c1cc(Br)ccc1NC(=O)COc1ccc([N+](=O)[O-])cc1
canonicalization
### Instruction: Canonicalize the following SMILES string. C1[NH+](CC(=O)N(C)C)CCN(CC1)C(=O)NCc1cscc1 ### Response: CN(C)C(=O)C[NH+]1CCCN(C(=O)NCc2ccsc2)CC1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. COCCC(=O)N[C@@H](C)c1ccc(-c2ccncc2)cc1 ### Response: 0
functional_group
### Instruction: Does the molecule contain a ester group? O=C(Nc1cncc2ccccc12)N[C@@H]1CCCc2occc21 ### Response: No
functional_group
### Instruction: Does the molecule contain a nitro group? COc1ccc(C[NH2+]C[C@@H](C(C)C)N2CCN(C)CC2)cc1O ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. n1(CCOC)ncc(c1)NC(NC[C@@H]1CCN(c2ccc(F)c(F)c2)C1)=O ### Response: COCCn1cc(NC(=O)NC[C@@H]2CCN(c3ccc(F)c(F)c3)C2)cn1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CN(C)C(=O)C1CCN(C(=O)NCc2cn(-c3ccccc3)nn2)CC1 ### Response: 1
functional_group
### Instruction: Does the molecule contain a sulfonyl group? Cc1sc(C(=O)N(C)[C@H]2CCC[C@@H]2S(C)(=O)=O)cc1[N+](=O)[O-] ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. c1c(C[NH3+])ccc(OCCCn2cccnc2=O)c1 ### Response: [NH3+]Cc1ccc(OCCCn2cccnc2=O)cc1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N[C@@H]([8*])c1ccccn1 Fragment 2: [4*]Cc1cc(C)c(O)c(C)c1 ### Response: Cc1cc(C[NH+]2CCC[C@@H]([C@H](NC(=O)c3cccc(F)c3)c3ccccn3)C2)cc(C)c1O
canonicalization
### Instruction: Canonicalize the following SMILES string. [O-]C(/C(C#N)=C\c1occc1)=N\S(=O)(c1cccc(OC)c1)=O ### Response: COc1cccc(S(=O)(=O)/N=C([O-])/C(C#N)=C\c2ccco2)c1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Cc1ccc(C(=O)N/C(=C\c2cccs2)C(=O)NCCN2CCOCC2)cc1 ### Response: 2
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Cc1ccc(Nc2nccc([C@@H]3CCCN3Cc3ccncc3)n2)nc1 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. O=C(CCOc1cccc(C)c1)Nc1ccc(-c2nnnn2C2CC2)cc1 ### Response: Cc1cccc(OCCC(=O)Nc2ccc(-c3nnnn3C3CC3)cc2)c1
canonicalization
### Instruction: Canonicalize the following SMILES string. C(Nc1c(OC(F)F)cccc1)(N1CCN(CC1)C(=O)C1CCCC1)=O ### Response: O=C(Nc1ccccc1OC(F)F)N1CCN(C(=O)C2CCCC2)CC1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]CC=C Fragment 2: [9*]n1cccn1 ### Response: C=CC[NH+](Cc1cccc(-n2cccn2)c1)[C@H]1CCS(=O)(=O)C1
canonicalization
### Instruction: Canonicalize the following SMILES string. C1C2CC3CC(CC1(NC(=O)NCCC(=O)OCC#C)C3)C2 ### Response: C#CCOC(=O)CCNC(=O)NC12CC3CC(CC(C3)C1)C2
ring_counting
### Instruction: Count the six-membered rings in the following molecule. O=C(CSc1nnc(NC2CC2)s1)c1ccc2c(c1)CCC2 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. [C@@H]1(CC(C(=O)NCCC(C)C)C[C@H](O1)C)C ### Response: CC(C)CCNC(=O)C1C[C@@H](C)O[C@@H](C)C1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CN1CC(=O)N2CCN(Cc3nc4ccc(F)cc4[nH]3)C[C@H]2C1=O ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. O(C(=O)[C@@](NC(=O)c1cc(C2CC2)nc2ccc(cc21)F)(C)CC)C ### Response: CC[C@@](C)(NC(=O)c1cc(C2CC2)nc2ccc(F)cc12)C(=O)OC
canonicalization
### Instruction: Canonicalize the following SMILES string. O=CNc1ccc(C(N2CCCC[C@@H]2c2[nH]c3c(cccc3)c2)=O)cc1 ### Response: O=CNc1ccc(C(=O)N2CCCC[C@@H]2c2cc3ccccc3[nH]2)cc1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC(C)[C@H](NC(=O)Cn1ccc(=O)c2ccccc21)c1ccccn1 ### Response: 3
canonicalization
### Instruction: Canonicalize the following SMILES string. Cc1ccc(cc1)-c1nn(C/C(N)=N/O)c(cc1)=O ### Response: Cc1ccc(-c2ccc(=O)n(C/C(N)=N/O)n2)cc1
functional_group
### Instruction: Does the molecule contain a amide group? O=C(CSc1ccc2c(c1)CCC2)Nc1nc(-c2ccc3c(c2)CCC(=O)N3)cs1 ### Response: Yes
ring_counting
### Instruction: Count the six-membered rings in the following molecule. O=C(NCCc1nc2ccccc2n1Cc1ccc(Cl)cc1)[C@@H]1CCCO1 ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COc1ccc(-c2n[nH]cc2C(=O)NCC(=O)NC(C)(C)C)cc1 ### Response: 3
functional_group
### Instruction: Does the molecule contain a sulfonyl group? CC[C@@H](/C([O-])=N/S(=O)(=O)c1cc(Cl)sc1Cl)c1ccccc1 ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COC(=O)c1cccc2c1N[C@H](c1ccccc1OC)[C@@H]1CC=C[C@H]21 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1ccc(N(C)[C@@H](CN)c2ccc(Br)c(C)c2)c(C)c1 ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COc1cccc(OC)c1OC1CC[NH+](Cc2ccc([C@H]3C[C@@H]3C)o2)CC1 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1cc(NC(=O)[C@@H](c2ccccc2)N2CCCCC2=O)sn1 ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]NCC(F)(F)F Fragment 2: [4*]Cc1ccc(C#N)cc1 ### Response: N#Cc1ccc(CNS(=O)(=O)c2ccc(C(=O)NCC(F)(F)F)cc2)cc1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1ccncc1[C@@H](C)[NH2+]CC1(CCCCC1)CCO ### Response: C[C@@H]([NH2+]CC1(CCO)CCCCC1)c1cccnc1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. O=C(NCc1ccco1)C(=O)Nc1cc(Cl)ccc1Cl ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC[C@@H](C#N)NC(=O)c1ccnc(OC2CCC2)c1 ### Response: 4
functional_group
### Instruction: Does the molecule contain a halide group? CCCC[C@]1(c2ccc(F)cc2)NC(=O)N(Cc2cc(=O)n3cccc(C)c3n2)C1=O ### Response: Yes
ring_counting
### Instruction: Count the five-membered rings in the following molecule. COC(=O)N1CC[C@@H](Nc2ncnc3nc(N)ccc23)C1 ### Response: 1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)c1ccco1)c1ccc2ccccc2c1 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [10*]N1C(=O)c2oc3c(C)cc(C)cc3c(=O)c2[C@H]1c1ccc(SC)cc1 Fragment 2: [8*]CCOC ### Response: COCCN1C(=O)c2oc3c(C)cc(C)cc3c(=O)c2[C@H]1c1ccc(SC)cc1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCN(CC)C(=O)NCc1cc(C#CC[NH3+])ccc1F ### Response: 3
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [16*]c1ccccc1 Fragment 2: [4*]CCN1CN([5*])C(=S)N([5*])C1 ### Response: S=C1N(c2ccccc2)CN(CCN2CCOCC2)CN1c1ccccc1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CC(C)[NH+](CC(N)=O)CC(=O)N(C)c1ccc([N+](=O)[O-])cc1 ### Response: 0
canonicalization
### Instruction: Canonicalize the following SMILES string. O=[S@]1C(C)(CN(Cc2cc(ccc2)OCc2ccccn2)CC1)C ### Response: CC1(C)CN(Cc2cccc(OCc3ccccn3)c2)CC[S@]1=O
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COc1ccc(Cl)cc1N(CC(=O)NN=C1CCN(C)CC1)S(=O)(=O)c1ccc(C)cc1 ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. O=S1(=O)N=C(c2cccc(c2)[N+](=O)[O-])[N-]c2c1cccc2 ### Response: O=[N+]([O-])c1cccc(C2=NS(=O)(=O)c3ccccc3[N-]2)c1
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? C[C@@H]1[NH2+]CCC[C@@H]1C(=O)Nc1cc(F)c(F)c(F)c1 ### Response: Yes
functional_group
### Instruction: Does the molecule contain a carboxyl group? CCn1ncnc1C[C@@H]([NH3+])[C@@H]1C[NH+](C)CCN1C ### Response: No
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CC1(C)C([NH2+][C@H]2CC[C@H]([NH3+])C2)C1(C)C ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cn1nc2c(cc1=O)CN(C(=O)NCc1csc(C3CC3)n1)CC2 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. C1CCC(C1)(c1c(F)cc(F)cc1)C(=O)NNC(=O)Cc1ccccn1 ### Response: O=C(Cc1ccccn1)NNC(=O)C1(c2ccc(F)cc2F)CCCC1
canonicalization
### Instruction: Canonicalize the following SMILES string. C1CC[C@H]([C@H](O)C1)[C@H]1N(C(C2CCC2)=O)CCCC1 ### Response: O=C(C1CCC1)N1CCCC[C@H]1[C@@H]1CCCC[C@H]1O
functional_group
### Instruction: Does the molecule contain a halide group? CC(C)[C@@H](NC(=O)C[C@@H](C)c1ccc(F)cc1)C(=O)N1CCOCC1 ### Response: Yes
functional_group
### Instruction: Does the molecule contain a nitro group? C[C@H]1CCCN(C(=O)CN2CCO[C@H](CN(C)c3cccnn3)C2)C1 ### Response: No
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [14*]c1ccco1 Fragment 2: [5*]Nc1ccc2ccn(C)c2c1 ### Response: Cn1ccc2ccc(NC(=O)C(=O)NC[C@@](C)(O)c3ccco3)cc21