task
stringclasses
5 values
input
stringlengths
89
339
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC[NH2+][C@H](C)c1cc(C)ccc1OCc1nc(C)c(C)s1 ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [14*]c1ccn(C)n1 Fragment 2: [4*][C@@H]([8*])c1ccc(Cl)cc1F ### Response: CC[NH2+][C@@H](c1ccn(C)n1)c1ccc(Cl)cc1F
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]Cc1ccc(Cl)cc1 Fragment 2: [5*]N1CCN(/N=C\c2ccc(C)o2)CC1 ### Response: Cc1ccc(/C=N\N2CCN(Cc3ccc(Cl)cc3)CC2)o1
functional_group
### Instruction: Does the molecule contain a ether group? C[C@@H]1CCCN(C(=O)C2CC[NH2+]CC2)C1 ### Response: No
ring_counting
### Instruction: Count the five-membered rings in the following molecule. C#CCN1C(=O)N=C(N)[C@]12CCCC[C@@H]2C ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1cccc(C(=O)N2CCN(c3cc(=O)n4nc(-c5ccccc5)sc4n3)CC2)c1 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC(C)C(=O)Nc1ccccc1[C@H]1[NH+]=c2ccccc2=[NH+]C1=O ### Response: 3
canonicalization
### Instruction: Canonicalize the following SMILES string. [C@H]1(COCC1)[C@@H](OC(=O)c1ccc(CSc2nccn2C)o1)C ### Response: C[C@H](OC(=O)c1ccc(CSc2nccn2C)o1)[C@H]1CCOC1
functional_group
### Instruction: Does the molecule contain a ether group? C[C@@H]1Cc2c(ccc(F)c2F)[C@@H]1Br ### Response: No
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [8*]CC(F)(F)F Fragment 2: [5*]Nc1cnn([9*])c1 ### Response: OCc1ccc(CNc2cnn(CC(F)(F)F)c2)o1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CNc1c(N/C(O)=[NH+]/Cc2ccc(F)cc2)c(=O)oc2ccccc12 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [9*]n1c(=O)[nH]c2ccccc21 Fragment 2: [5*]N1CCC([15*])CC1 ### Response: O=c1[nH]c2ccccc2n1C1CCN(c2cc(-n3ccnc3)ncn2)CC1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Cc1ccnc(C[C@@H](C)O)c1 ### Response: 0
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC[NH2+][C@@]1(C(=O)[O-])CCC[C@@H](Sc2ncc(C)cn2)C1 ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)c1c(CC)noc1C Fragment 2: [16*]c1ccccc1 ### Response: CCc1noc(C)c1C(=O)N[C@@H]1C[C@H](C)N(c2ccccc2)C1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(OCC)ccccc1C(N1CCN(CC1)C(NCc1ccccn1)=O)=O ### Response: CCOc1ccccc1C(=O)N1CCN(C(=O)NCc2ccccn2)CC1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]Cc1ccccc1 Fragment 2: [1*]C(=O)[C@@H]1CCC[NH+]1[5*] ### Response: CN(C)c1ccc(NC(=O)[C@@H]2CCC[NH+]2Cc2ccccc2)cc1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]Nc1ccc(OC)cc1 Fragment 2: [3*]OCC([7*])[O-] ### Response: COc1ccc(NC(=O)/C(C#N)=C(/[O-])COc2ccc(C)c(C)c2)cc1
canonicalization
### Instruction: Canonicalize the following SMILES string. O=C(C1=C([C@@](c2ccccc2)([C@H](O1)c1ccccc1)O)C(=O)OC)OC ### Response: COC(=O)C1=C(C(=O)OC)[C@@](O)(c2ccccc2)[C@@H](c2ccccc2)O1
canonicalization
### Instruction: Canonicalize the following SMILES string. C1(c2ccccc2)C[C@H](c2ccc(OC)cc2)N(C(=O)CN2C(SCC2=O)=O)N=1 ### Response: COc1ccc([C@H]2CC(c3ccccc3)=NN2C(=O)CN2C(=O)CSC2=O)cc1
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? CC[C@@H](C)CN(C)C(=O)Nc1cc(-c2ncco2)ccc1C ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. N(S(=O)(c1ccc(cc1)F)=O)CCC(=O)N1C[C@H](CCC)OCC1 ### Response: CCC[C@H]1CN(C(=O)CCNS(=O)(=O)c2ccc(F)cc2)CCO1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@H](NC(=O)NCCOC[C@H]1CCCO1)c1ccc(Cl)s1 ### Response: 2
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? C[C@H](NC(=O)CC1CCC1)c1ccc(S(N)(=O)=O)cc1 ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COc1ccc([C@@H]2N=C(c3cccc(Br)c3)C[C@@H](c3ccccc3O)[NH2+]2)cc1 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1c(ccc(c1)CC(N1CCN(CC1)CC(F)(F)F)=O)Cl ### Response: O=C(Cc1ccc(Cl)cc1)N1CCN(CC(F)(F)F)CC1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1cc(CCNC(=O)N2CCC(CC2)CSc2nccn2C)ccc1OC ### Response: COc1ccc(CCNC(=O)N2CCC(CSc3nccn3C)CC2)cc1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [7*]Cc1cc(Br)ccc1OC Fragment 2: [5*]N1CCN([5*])CC1 ### Response: COc1ccc(Br)cc1/C=C/C(=O)N1CCN(C(=O)c2ccccc2)CC1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. COc1cccc(/C=C2/SC(=S)N(c3cccc(Cl)c3)C2=O)c1 ### Response: 2
functional_group
### Instruction: Does the molecule contain a ether group? COC(=O)CCn1ccc2c(Cl)cccc21 ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]Nc1ccc(Cl)cc1N Fragment 2: [16*]c1cnn(C)c1 ### Response: Cn1cc(Nc2ccc(Cl)cc2N)cn1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. O=C([C@@H]1C[C@@H]1c1cc(F)ccc1F)N1CCc2cc(F)ccc2C1 ### Response: 0
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)c1c([N+](=O)[O-])cnn1CC Fragment 2: [3*]OCC ### Response: CCOC(=O)c1c(NC(=O)c2c([N+](=O)[O-])cnn2CC)sc2c1CCCC2
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CC(C)CCNC(=O)[C@H]1CCCN(c2ccnc(-c3cccc(F)c3)n2)C1 ### Response: 0
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)NCC[4*] Fragment 2: [5*]Nc1ccc([16*])c(F)c1 ### Response: O=C(NCCN1CCOCC1)Nc1ccc(N2CCOCC2)c(F)c1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCC[C@@H](C)N1CCC[NH2+]CC1 ### Response: 5
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [9*]n1cc([N+](=O)[O-])cc([16*])c1=O Fragment 2: [6*]C(N)=O ### Response: NC(=O)c1cc([N+](=O)[O-])cn(C[C@@H](O)COc2cc(Cl)ccc2Cl)c1=O
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1cc2oc3c(c(=O)c2cc1Cl)[C@H](c1cccnc1)N(CCCN1CCOCC1)C3=O ### Response: 3
functional_group
### Instruction: Does the molecule contain a ether group? CC(C)[C@@H](CCOCCO)[C@@H](C)O ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [8*]CC(=O)OC Fragment 2: [8*]C(F)F ### Response: COC(=O)C[C@H]1CCCCN1c1ccc2nnc(C(F)F)n2n1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [9*]n1c(C)nc2ccccc21 Fragment 2: [1*]C(=O)c1ccccc1[16*] ### Response: Cc1nc2ccccc2n1CCNC(=O)c1ccccc1S[C@@H]1CCS(=O)(=O)C1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CN([C@@H]1CCSC1)C1(C[NH3+])CCCCCCCCCCC1 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. [NH2+](CC)C[C@@H]1CCO[C@@H]1C1CCCCCC1 ### Response: CC[NH2+]C[C@@H]1CCO[C@@H]1C1CCCCCC1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)CC[8*] Fragment 2: [12*]S(=O)(=O)c1ccc([16*])cc1 ### Response: CC[C@@H](C)c1ccc(S(=O)(=O)N2CCN(C(=O)CCc3c(C)nc4nc(N)nn4c3C)CC2)cc1
functional_group
### Instruction: Does the molecule contain a aldehyde group? COc1ccc(OC)c([C@@H](C)NC(=O)[C@@H](C)Nc2ccc3c(c2)CCO3)c1 ### Response: No
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]Cc1sccc1C#CCCO Fragment 2: [4*]C[C@@H](O)CO ### Response: OCCC#Cc1ccsc1CSC[C@@H](O)CO
ring_counting
### Instruction: Count the six-membered rings in the following molecule. O=C(Nc1c(C(=O)N2CCOCC2)cnn1-c1ccccc1)c1cccs1 ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]Nc1ccccc1F Fragment 2: [1*]C(=O)[C@@H]1C[C@H]2CC[C@@H]1C2 ### Response: O=C(Nc1ccccc1F)[C@@H]1C[C@H]2CC[C@@H]1C2
functional_group
### Instruction: Does the molecule contain a amine group? COc1c(C)cc(S(=O)(=O)N2CCN(C(C)=O)CC2)c(C)c1C ### Response: No
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [12*]S(=O)(=O)c1ccccc1Br Fragment 2: [5*]N[C@@H]1CCSc2ccc(F)cc21 ### Response: O=S(=O)(N[C@@H]1CCSc2ccc(F)cc21)c1ccccc1Br
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COc1cccc(/C=N/NC(=O)C[C@@H](C)O)c1 ### Response: 4
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CCCCc1cc(NC(=O)c2ccc(N3CCC(C)=N3)cc2)[nH]n1 ### Response: 1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. O=C(NC1(CO)CCCC1)[C@H]1CC[C@@H]2CCCC[C@H]2[NH2+]1 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Brc1cc2c(cc1[C@H]1Nc3ccccc3[C@@H]3C=CC[C@@H]13)OCO2 ### Response: 0
canonicalization
### Instruction: Canonicalize the following SMILES string. C(OC)[C@H]1CCN(C1)C(=O)c1ccc(OC2CC[NH+](CC2)C2CCCC2)c(OC)c1 ### Response: COC[C@H]1CCN(C(=O)c2ccc(OC3CC[NH+](C4CCCC4)CC3)c(OC)c2)C1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [3*]Oc1ccc([C@@H]([4*])C)cc1 Fragment 2: [5*]NCC#C ### Response: C#CCNC(=O)N[C@@H](C)c1ccc(OC(C)C)cc1
functional_group
### Instruction: Does the molecule contain a amide group? Cc1cc(C)n(CC(=O)NNC(=O)NCc2ccsc2)n1 ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCOC(=O)C1=C(N)Nc2ccccc2[C@@]12C(=O)OC(C)=C2C(=O)OC(C)(C)C ### Response: 3
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [8*]C(F)(F)F Fragment 2: [5*]N[C@@]1([13*])[N-]C(c2ccccc2)=NC1=O ### Response: CC(C)CC(=O)N[C@@]1(C(F)(F)F)[N-]C(c2ccccc2)=NC1=O
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)CC[8*] Fragment 2: [5*]N1C[C@@H]([15*])[C@H]([15*])C1 ### Response: O=C([O-])[C@@H]1CN(C(=O)CCn2ccc(=O)[nH]c2=O)C[C@H]1c1ccccc1
canonicalization
### Instruction: Canonicalize the following SMILES string. [C@@H]1(C(C(=O)OCC)=C(C)NC2C[C@H](c3cccs3)CC(C1=2)=O)c1ccc(cc1)OC(=O)C ### Response: CCOC(=O)C1=C(C)NC2=C(C(=O)C[C@@H](c3cccs3)C2)[C@H]1c1ccc(OC(C)=O)cc1
functional_group
### Instruction: Does the molecule contain a nitro group? O=C(NC12CC3CC(CC(C3)C1)C2)c1cc(F)ccc1F ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. O=C(N[C@H](c1sccc1)CC)Nc1c(cccc1)OCC ### Response: CCOc1ccccc1NC(=O)N[C@@H](CC)c1cccs1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [9*]n1cnnn1 Fragment 2: [14*]c1nc(C)no1 ### Response: Cc1noc([C@H](C)Oc2ccc(-n3cnnn3)cc2)n1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]C[C@@H]1CCCO1 Fragment 2: [5*]N([5*])C[C@@H]1CCCO1 ### Response: Cc1ccc(S(=O)(=O)N2CCOCC2)cc1C(=O)N(Cc1cccs1)C[C@@H]1CCCO1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [8*]C(C)(C)C Fragment 2: [16*]c1ccc(F)c(F)c1 ### Response: CCN(C(=O)c1cc(C2CC2)n(C(C)(C)C)n1)c1ccc(F)c(F)c1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [16*]c1cc(Cl)ccc1C Fragment 2: [5*]N1CC[NH+]([5*])CC1 ### Response: Cc1ccc(Cl)cc1N1CC[NH+](C[C@H]2C(=O)O[C@@H]3C[C@@]4(C)CCC[C@]5(CO5)[C@@H]4C[C@@H]32)CC1
functional_group
### Instruction: Does the molecule contain a ester group? COCc1nc(C)cc(N[C@@H]2CCC[C@H]2C(N)=O)n1 ### Response: No
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COc1ccccc1COC(=O)COc1ccc2ccccc2c1 ### Response: 2
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Cc1noc([C@H]2CN(C(=O)N(C)C)CC23CCOCC3)n1 ### Response: 1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CCc1nn(C)cc1CNC(=O)[C@H]1CCCCN1C(=O)c1cccnc1 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? OCCC#Cc1cc(F)cc(C[NH+]2CCC[C@H]2CO)c1 ### Response: 4
ring_counting
### Instruction: Count the five-membered rings in the following molecule. COC(=O)Cn1/c(=N\C(=O)Cc2ccc(OC)c(C)c2)sc2cc(S(C)(=O)=O)ccc21 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COc1cccc(C(=O)N[C@H](c2ccco2)c2c(O)ccc3ccccc23)c1 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1ccc(NC(=O)NC(=O)CN(C)CC[NH+]2CCCC2)c(C)c1 ### Response: 2
functional_group
### Instruction: Does the molecule contain a halide group? CCOC(=O)c1csc(N(C)C(=O)c2cnc3ccc(F)cc3c2)n1 ### Response: Yes
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CC(C)c1cnc(CN2CCC[C@@H]2[C@@H](C#N)c2ccccc2)o1 ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@H](CSc1ccc(C(=O)N(C)C)cn1)C(=O)[O-] ### Response: 3
ring_counting
### Instruction: Count the six-membered rings in the following molecule. C[NH2+][C@H](C)CCc1nc([C@@]2(C)CCCO2)no1 ### Response: 0
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@@H](C(=O)N1CCC[C@@H](C(N)=O)C1)[NH+]1CC=C(c2ccccc2Cl)CC1 ### Response: 3
canonicalization
### Instruction: Canonicalize the following SMILES string. C1CC1N1C(=O)C[NH+](CC1)Cc1cc(OCC)c(c(c1)Cl)OC ### Response: CCOc1cc(C[NH+]2CCN(C3CC3)C(=O)C2)cc(Cl)c1OC
functional_group
### Instruction: Does the molecule contain a ketone group? COc1ccc([C@H](C)[NH2+][C@@H]2CCCCC[C@@H]2CO)c(OC)c1 ### Response: No
functional_group
### Instruction: Does the molecule contain a aldehyde group? Cc1ccc(-c2n[nH]cc2C=O)s1 ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C(Nc1cccc(OC(F)F)c1)c1cccnc1OCC(F)F ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1cccc([C@H]2CCCC[NH+]2Cc2noc(C3CC3)n2)c1C ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(cc([nH]cc1C(=O)N1CCCc2c1ccc(c2)C)C)=O ### Response: Cc1ccc2c(c1)CCCN2C(=O)c1c[nH]c(C)cc1=O
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1ccc(Cl)c2sc(N3CCN(C(=O)c4ccc5ncsc5c4)CC3)nc12 ### Response: 1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. COc1cccc([C@H](CNS(=O)(=O)c2ccc(Br)cc2Cl)[NH+](C)C)c1 ### Response: 0
canonicalization
### Instruction: Canonicalize the following SMILES string. [C@@H]1(C)CCCC[C@H]1NC([C@H](N1Cc2nn(C)c(n2CC1)=O)C)=O ### Response: C[C@@H]1CCCC[C@H]1NC(=O)[C@@H](C)N1CCn2c(nn(C)c2=O)C1
canonicalization
### Instruction: Canonicalize the following SMILES string. N(C(=O)N1CCN(CC1)[C@H](CO)CC)c1n(ncc1)Cc1ccccn1 ### Response: CC[C@@H](CO)N1CCN(C(=O)Nc2ccnn2Cc2ccccn2)CC1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [14*]c1ccccn1 Fragment 2: [5*]NC(=S)N[5*] ### Response: O=C(NC(=S)Nc1ccccn1)c1ccc(Cl)cc1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CC[C@@H](C)[C@@H](NC(=O)c1cccc(F)c1)C(=O)N=c1[nH]c2ccccc2[nH]1 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(OCCn2c[nH+]cc2)ccc2c(c1)ccc(C(C)=O)c2 ### Response: CC(=O)c1ccc2cc(OCCn3cc[nH+]c3)ccc2c1
functional_group
### Instruction: Does the molecule contain a carboxyl group? CC[C@]1(c2ccc(Cl)cc2)NC(=O)N(CC(=O)c2ccccc2)C1=O ### Response: No
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCOC(=O)[C@@H](c1ccc(F)cc1)N1CCC(=O)CC1 ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1cccc(CN2c3ccccc3C(=O)/C(=C\Nc3cc(C)cc(C)c3)S2(=O)=O)c1 ### Response: 1
functional_group
### Instruction: Does the molecule contain a hydroxyl group? C/[NH+]=C(\NCC(C)(C)c1ccc(OC)cc1)N[C@H]1C[C@H]1C ### Response: No
functional_group
### Instruction: Does the molecule contain a nitro group? Cc1ccc(CNC(=O)NC[C@@H](CC(C)C)C(=O)[O-])s1 ### Response: No
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCOc1cccc([C@H]([NH3+])CSc2ccc(C)cc2)c1 ### Response: 2
functional_group
### Instruction: Does the molecule contain a amide group? Cc1csc(CNC(=O)N[C@H]2CC[NH+]3CCCC[C@H]23)n1 ### Response: Yes