task
stringclasses
5 values
input
stringlengths
89
339
functional_group
### Instruction: Does the molecule contain a amide group? CCCNC(=O)c1sc(C)nc1C ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. n1ccncc1Oc1ccc(C[NH+](C[C@@H]2COCC2)C)cc1 ### Response: C[NH+](Cc1ccc(Oc2cnccn2)cc1)C[C@H]1CCOC1
functional_group
### Instruction: Does the molecule contain a phenol group? Oc1ccc(Br)cc1/C=N/c1cccc(F)c1 ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)c1ncn2c1C(=O)N([10*])[C@@](C)(C([1*])=O)C2 Fragment 2: [5*]NCc1cccc(F)c1 ### Response: CCCN1C(=O)c2c(C(=O)NCc3cccc(F)c3)ncn2C[C@]1(C)C(=O)NC1CCCC1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]CC(=O)[O-] Fragment 2: [3*]OCC(=O)[O-] ### Response: Cc1nc2ccc(OCC(=O)[O-])cc2c(=O)n1-c1ccc2c(c1)OCO2
ring_counting
### Instruction: Count the five-membered rings in the following molecule. C[C@H](c1ccc(F)cc1)N1Cc2cc(NC(=O)COc3ccccc3)ccc2OCC1=O ### Response: 0
ring_counting
### Instruction: Count the five-membered rings in the following molecule. O=[N+]([O-])c1ccc2c(c1)CCC2 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [6*]C(=O)c1ccco1 Fragment 2: [14*]c1ccco1 ### Response: Cc1ccc([N+](=O)[O-])cc1N1C(=O)[C@@H]2[C@H](C1=O)[C@H]1C=Cc3ccccc3N1[C@H]2C(=O)c1ccco1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Cc1c([C@H]2CCC[NH+]2Cc2cc(C(F)(F)F)ccc2F)cnn1C ### Response: 1
functional_group
### Instruction: Does the molecule contain a halide group? C[C@@H]1Cc2ccccc2N1S(=O)(=O)Cc1ccc(Br)cc1 ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. C(C)C[C@@H](C)C(NCc1c(C)cccc1)=O ### Response: CCC[C@@H](C)C(=O)NCc1ccccc1C
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(sc(C(=O)NCCc2ncnn2C)c(OC)c1Br)C ### Response: COc1c(C(=O)NCCc2ncnn2C)sc(C)c1Br
ring_counting
### Instruction: Count the five-membered rings in the following molecule. C[C@H](Sc1cccc[n+]1[O-])C(=O)NC[C@H]1COc2ccccc2O1 ### Response: 0
canonicalization
### Instruction: Canonicalize the following SMILES string. n1(C)ccnc1[C@@H]([C@H]1CCC[NH+](C1)Cc1cc(ccc1)-c1cccnc1)O ### Response: Cn1ccnc1[C@H](O)[C@H]1CCC[NH+](Cc2cccc(-c3cccnc3)c2)C1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Cc1sc2nc(CS[C@H](C)C(=O)N(Cc3ccccn3)c3ccc(F)cc3)[nH]c(=O)c2c1C ### Response: 3
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*][C@H]([8*])Cc1ccc(C)cc1 Fragment 2: [1*]C(=O)N([5*])C ### Response: Cc1ccc(C[C@H](NC(=O)N(C)C[C@@H](C)O)c2ccccn2)cc1
functional_group
### Instruction: Does the molecule contain a ether group? Cc1ccc(N/C([S-])=[NH+]/Cc2ccccc2)cc1[N+](=O)[O-] ### Response: No
ring_counting
### Instruction: Count the five-membered rings in the following molecule. C[C@@H]1Cc2ccccc2N1CCNC(=O)Cc1cc(Cl)c2c(c1)OCCO2 ### Response: 1
functional_group
### Instruction: Does the molecule contain a amide group? Cc1nc(NC(=O)CCc2cc(F)ccc2F)sc1-c1nnc([S-])n1C ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COc1ccc(Cl)cc1NC(=O)c1sc2nc(-c3cccnc3)ccc2c1N ### Response: 1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Clc1ccnc(-c2cccc(C3CC3)c2)n1 ### Response: 2
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Cc1ccc(CN2CCOC3(CCC3)C2)c(C)c1 ### Response: 0
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COc1cccc(CNC(=O)Cc2cccc(F)c2F)c1O ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. S(CC(N(C)C1=CCCC1)=O)c1oc(-c2ccc(C)cc2)nn1 ### Response: Cc1ccc(-c2nnc(SCC(=O)N(C)C3=CCCC3)o2)cc1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CCC(=O)Oc1cccc2ccc(/C=C/c3ccccc3[N+](=O)[O-])nc12 ### Response: 0
functional_group
### Instruction: Does the molecule contain a hydroxyl group? O=C(OC[C@@H]1CN(Cc2ccccc2)CCO1)c1ccncc1Cl ### Response: No
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [16*]c1ccccc1 Fragment 2: [14*]c1nc2ccccn2c1[N+](=O)[O-] ### Response: O=[N+]([O-])c1c(-c2ccccc2)nc2ccccn12
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]Nc1ccc([16*])cc1 Fragment 2: [1*]C(=O)c1ccccc1[N+](=O)[O-] ### Response: CC(C)c1ccc(NC(=O)c2ccccc2[N+](=O)[O-])cc1
functional_group
### Instruction: Does the molecule contain a halide group? CCOc1cccc(C(=O)c2c(C)c(C#N)c(=O)n(C)c2[O-])c1 ### Response: No
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCc1ccc(/C=C2\Cc3c(O)cccc3C2=O)cc1 ### Response: 2
functional_group
### Instruction: Does the molecule contain a phenol group? CC[C@@H](C)[C@@H](NC(=O)c1cccc(F)c1)C(=O)N=c1[nH]c2ccccc2[nH]1 ### Response: No
functional_group
### Instruction: Does the molecule contain a carboxyl group? Cc1ccc(C(=O)Nc2cccc(C(=O)Nc3ccccc3)c2)cc1Br ### Response: No
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CC(C)CONc1ncnc2sc3c(c12)CCC3 ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [15*]C1CCCCC1 Fragment 2: [5*]NC1CCCCC1 ### Response: CCN(C(=O)CNC(=O)NC1CCCCC1)c1cc(C)ccc1C
canonicalization
### Instruction: Canonicalize the following SMILES string. c1c(ccc(OC)c1)[C@H]1[C@H](C(=O)NCc2cccnc2)CCC(N1C)=O ### Response: COc1ccc([C@H]2[C@H](C(=O)NCc3cccnc3)CCC(=O)N2C)cc1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CC[C@H](NC(=O)Nc1nc(C(C)C)nn1C)c1ccc(F)cc1F ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@H]1OCC[C@@H]1N[C@H](c1cccnc1)c1cccc(C(F)(F)F)c1 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC[C@@H](C)C[NH+](CC)CC(=O)c1cccc(Cl)c1 ### Response: 4
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC1CCN(C(=O)C[NH+]2C[C@@H](C)CC[C@@H]2C)CC1 ### Response: 2
functional_group
### Instruction: Does the molecule contain a thiol group? CC(C)Oc1ccc(NC(=O)NCc2ccc([N+](=O)[O-])cc2)cc1 ### Response: No
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1c(C(=O)NCCNC(=O)c2cccnc2)cnn1-c1ccncc1 ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [8*]CCC1=C[C@H](O)OC1=O Fragment 2: [15*][C@@]1(C)[C@H](C)C[C@@H](O)[C@@]2(C)C(C(=O)[O-])=CCC[C@H]12 ### Response: C[C@@H]1C[C@@H](O)[C@@]2(C)C(C(=O)[O-])=CCC[C@@H]2[C@@]1(C)CCC1=C[C@H](O)OC1=O
ring_counting
### Instruction: Count the five-membered rings in the following molecule. COC(=O)[C@@H]1CCN(C(=O)[C@H]2CCSC2)C1 ### Response: 2
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? Cc1csc(C[NH+]2CCC[C@@H]2CC(C)(C)C)n1 ### Response: No
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC(C)N(C)C(=O)C1CCN(CN2C(=O)[C@@H]3CC=CC[C@H]3C2=O)CC1 ### Response: 3
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]NCC1([15*])CCOCC1 Fragment 2: [1*]C(=O)[C@H]1CC(=O)N([10*])C1 ### Response: COc1ccc(C2(CNC(=O)[C@H]3CC(=O)N(c4ccc(C)cc4)C3)CCOCC2)cc1
canonicalization
### Instruction: Canonicalize the following SMILES string. C(N(Cc1sccc1)CC)(=O)N[C@@H](C)c1cc(c(cc1C)OC)OC ### Response: CCN(Cc1cccs1)C(=O)N[C@@H](C)c1cc(OC)c(OC)cc1C
canonicalization
### Instruction: Canonicalize the following SMILES string. O=C([C@@H]1[C@H](CN(C(=O)c2ncsc2)C1)c1ccc(cc1)F)OC ### Response: COC(=O)[C@H]1CN(C(=O)c2cscn2)C[C@@H]1c1ccc(F)cc1
canonicalization
### Instruction: Canonicalize the following SMILES string. C1[NH2+]CCC[C@@H]1NCc1c(C)n(C)nc1C ### Response: Cc1nn(C)c(C)c1CN[C@H]1CCC[NH2+]C1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCc1nn(C)cc1CNC(=O)c1cc(C)nc2ccc(OC)cc12 ### Response: 2
functional_group
### Instruction: Does the molecule contain a halide group? Clc1cccc(Cl)c1-c1cnc(C[NH2+]Cc2cccs2)s1 ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)C(=O)N/N=C/c1c(C)cc(C)cc1C Fragment 2: [5*]Nc1ccc([16*])cc1 ### Response: Cc1cc(C)c(/C=N/NC(=O)C(=O)Nc2ccc(C(=O)[O-])cc2)c(C)c1
functional_group
### Instruction: Does the molecule contain a amide group? CCCC(=O)N1CCN(c2nc3c(c(=O)[nH]c(=O)n3C)n2Cc2ccc(C)cc2)CC1 ### Response: Yes
functional_group
### Instruction: Does the molecule contain a amide group? O=C(/C=C\c1cccs1)O[C@@H](c1ccccc1)c1ccccn1 ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. [N+]([O-])(c1cc(ccc1C)NC(=O)N(Cc1occc1)C[C@@H]1OCCC1)=O ### Response: Cc1ccc(NC(=O)N(Cc2ccco2)C[C@H]2CCCO2)cc1[N+](=O)[O-]
functional_group
### Instruction: Does the molecule contain a hydroxyl group? C[NH+](CCCO)C1CCN(Cc2c[nH]c[nH+]2)CC1 ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COc1ccc(CN(C)C(=O)/C=C/c2cn(C)c(=O)n(C)c2=O)cc1 ### Response: 3
canonicalization
### Instruction: Canonicalize the following SMILES string. C1[C@H](C)CCc2c1sc1nc([nH]c(c12)=O)[C@@H](N1CCN(C(=O)[C@@H]2COc3ccccc3O2)CC1)C ### Response: C[C@@H]1CCc2c(sc3nc([C@H](C)N4CCN(C(=O)[C@@H]5COc6ccccc6O5)CC4)[nH]c(=O)c23)C1
canonicalization
### Instruction: Canonicalize the following SMILES string. O=c1n(c2c(n(cn2)CC(Nc2cc(F)ccc2)=O)c(n1C)=O)C ### Response: Cn1c(=O)c2c(ncn2CC(=O)Nc2cccc(F)c2)n(C)c1=O
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1ccc(-n2c(C)c(C)n3c4c(=O)n(C)c(=O)n(C)c4nc23)cc1 ### Response: 1
functional_group
### Instruction: Does the molecule contain a aldehyde group? CCC(CC)[C@H](CNC(=O)c1cnc2c(C)cccn2c1=O)[NH+](C)C ### Response: No
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [16*]c1ccc2c(c1)OCCO2 Fragment 2: [1*]C(=O)c1ccc(S(=O)(=O)N([5*])C)cc1 ### Response: CC(C)N(C)S(=O)(=O)c1ccc(C(=O)Nc2nnc(-c3ccc4c(c3)OCCO4)o2)cc1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [8*]Cc1ccc(F)cc1 Fragment 2: [5*][NH+]1CC[C@H]2[C@H](CCC(=O)N2[10*])C1 ### Response: CC(C)C[NH+]1CC[C@H]2[C@H](CCC(=O)N2Cc2ccc(F)cc2)C1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Cc1cccnc1NC(=O)[C@H]1CCCN(c2cnc3ccccc3n2)C1 ### Response: 4
functional_group
### Instruction: Does the molecule contain a amide group? Cc1ccccc1[C@@H](C)NC(=O)c1cc(-c2ccncc2)nc2ccccc12 ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1ccc(OCCNC(=O)/C=C/c2cccc(F)c2)cc1 ### Response: 3
canonicalization
### Instruction: Canonicalize the following SMILES string. c1cc([C@H](C)NC(Cn2cncc2)=O)ccc1-c1ccccc1 ### Response: C[C@H](NC(=O)Cn1ccnc1)c1ccc(-c2ccccc2)cc1
functional_group
### Instruction: Does the molecule contain a ether group? CCOC(=O)c1cnn([C@H]2CCCN(C(=O)N[C@@H](C)c3ccc(C)o3)C2)c1 ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. n1c(cc(C)nc1-n1c(NC(c2c(nc(cc2)Cl)Cl)=O)cc(C)n1)C ### Response: Cc1cc(C)nc(-n2nc(C)cc2NC(=O)c2ccc(Cl)nc2Cl)n1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1ccc([C@H]2C(C(=O)c3c(C)nc4c(C)cccn34)=C([O-])C(=O)N2CCN2CCOCC2)cc1 ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. C(CN1CC[NH+](CC1)Cc1cccc2cccnc12)(Nc1ccc(cc1)C(N(C)C)=O)=O ### Response: CN(C)C(=O)c1ccc(NC(=O)CN2CC[NH+](Cc3cccc4cccnc34)CC2)cc1
functional_group
### Instruction: Does the molecule contain a sulfonyl group? CC[C@@H]1CN(S(=O)(=O)C(C)C)CC[C@@H]1[NH2+]Cc1cccc(C#N)c1 ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. C1[C@@]2(CC3C[C@]1(CC(C2)([C@H](O)CC=C)C3)C)C ### Response: C=CC[C@@H](O)C12CC3C[C@@](C)(C1)C[C@](C)(C3)C2
canonicalization
### Instruction: Canonicalize the following SMILES string. CC1(C)CCCC[C@]1(Cc1cc(ccc1OC)Br)O ### Response: COc1ccc(Br)cc1C[C@]1(O)CCCCC1(C)C
ring_counting
### Instruction: Count the five-membered rings in the following molecule. NC(=O)c1c(NC(=O)c2cc([N+](=O)[O-])ccc2N2CCOCC2)sc2c1CCC2 ### Response: 2
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Fc1ccc(/C=C/CN2CCO[C@@H](c3ccsc3)C2)cc1 ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [16*]c1c(C)[nH]c2ccccc12 Fragment 2: [5*]NC1CC1 ### Response: Cc1[nH]c2ccccc2c1C1CC[NH+](CC(=O)NC2CC2)CC1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. C[C@H]1C[C@H](C)CN(S(=O)(=O)NCCc2nccn2Cc2ccccc2)C1 ### Response: 1
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? C[C@@H](NCC1(c2ccc(F)cc2)CC1)c1ccc(S(N)(=O)=O)cc1 ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1cc(C(=O)N2CCn3c(C)nnc3C2)c(C)n1Cc1ccco1 ### Response: 1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CCOC(=O)C1(NCc2nnc(-c3cc(C)oc3C)o2)CCCC1 ### Response: 0
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]Cc1cccnc1[14*] Fragment 2: [3*]OCC ### Response: CCOc1ncccc1CNC(=O)NCCc1nnc2n1CCC2
functional_group
### Instruction: Does the molecule contain a nitrile group? CC(C)CCOc1ccc(NC(=O)c2nccnc2N)cc1 ### Response: No
functional_group
### Instruction: Does the molecule contain a nitrile group? O=C1NC2=C(C(=O)N(Cc3ccc(F)cc3)C2)[C@H](c2ccccc2F)N1 ### Response: No
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CCc1nn(C)cc1CNC[C@@H](c1ccc(C)o1)N1CCOCC1 ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)CS(=O)(=O)CC Fragment 2: [5*]N1CCC2(CC1)c1nc[nH]c1CCN2[5*] ### Response: CCS(=O)(=O)CC(=O)N1CCC2(CC1)c1nc[nH]c1CCN2C(=O)C1CC1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [9*]n1ccc2ccc(OC)cc2c1=O Fragment 2: [4*]CCC[8*] ### Response: COc1ccc2ccn(CCCOc3ccc([N+](=O)[O-])cc3)c(=O)c2c1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCOCc1ccccc1NC(=O)c1ccc(-c2cscn2)cc1 ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. O=C1NC2(CCC(C)CC2)C(=O)N1NC(=O)CCC1=c2ccccc2=[NH+]C1 ### Response: CC1CCC2(CC1)NC(=O)N(NC(=O)CCC1=c3ccccc3=[NH+]C1)C2=O
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC[NH2+][C@H](c1ccc(F)cc1C)[C@@H]1CN(CC)CCO1 ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. [C@]1(CC[NH+](C1)Cc1c(F)cccc1F)(C(F)(F)F)O ### Response: O[C@]1(C(F)(F)F)CC[NH+](Cc2c(F)cccc2F)C1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)C[C@H]1CSc2ncc(C)c(=O)n21 Fragment 2: [5*]N1CCCc2ccccc21 ### Response: Cc1cnc2n(c1=O)[C@@H](CC(=O)N1CCCc3ccccc31)CS2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*][NH+]1CCCC[C@H]1C[8*] Fragment 2: [8*]Cc1ccccc1 ### Response: Cc1cnc(C[NH+]2CCCC[C@H]2Cc2ccccc2)o1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)OCC Fragment 2: [1*]C(=O)N[C@@H]1CC2(CCCCC2)Oc2ccccc21 ### Response: CCOC(=O)N[C@@H]1CC2(CCCCC2)Oc2ccccc21
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C(NCc1cnn(-c2ccccc2)c1)N[C@H]1CCCc2ccccc21 ### Response: 1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CCNS(=O)(=O)c1ccc(C)c(C(=O)N2CC[S@@](=O)C(C)(C)C2)c1 ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)[C@@H](C)N[5*] Fragment 2: [1*]C(=O)N1CCN([5*])CC1 ### Response: COc1cccc(CNC(=O)[C@@H](C)NC(=O)N2CCN(C(=O)c3cc4ccccc4[nH]3)CC2)c1
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? C[C@H](NC(=O)N(C)Cc1cnccn1)c1cccc(-n2ccnc2)c1 ### Response: Yes
functional_group
### Instruction: Does the molecule contain a ether group? COC1CCC(CC(=O)NC[C@H](C)c2nc(-c3ccccc3)no2)CC1 ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COc1ccc(/C=c2\s/c(=C(/C#N)c3nnc4n3CCCCC4)n(-c3ccccc3)c2=O)cc1OC ### Response: 2