task
stringclasses
5 values
input
stringlengths
89
339
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N[C@H](CO)C(C)C Fragment 2: [1*]C(=O)c1ccncc1 ### Response: CC(C)[C@@H](CO)NC(=O)c1ccncc1
canonicalization
### Instruction: Canonicalize the following SMILES string. [O-][N+](=O)c1c(-n2c(c(N)nn2)C)cccc1 ### Response: Cc1c(N)nnn1-c1ccccc1[N+](=O)[O-]
canonicalization
### Instruction: Canonicalize the following SMILES string. c1c(cc(cc1Cl)C(=O)NCc1ccc(cc1)Cl)Cl ### Response: O=C(NCc1ccc(Cl)cc1)c1cc(Cl)cc(Cl)c1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]CCS(C)(=O)=O Fragment 2: [4*]Cc1cccc([16*])c1 ### Response: CS(=O)(=O)CC[NH2+]Cc1cccc(C2CC2)c1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC1=NC(C)=C(C(=O)N2CCCCC2)[C@H]1S(=O)(=O)NC1CC1 ### Response: 1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CC(=O)c1cnc2c(-c3ccc(C)cc3)c(C)nn2c1C ### Response: 1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. C[C@@H]1CCCN(C(=O)N2CCCC[C@@H]2CCO)C1 ### Response: 2
functional_group
### Instruction: Does the molecule contain a sulfonyl group? COc1ccc2c(c1)c(C)c(C(=O)N1CCCC[C@@H]1C[NH+](C)C)n2C ### Response: No
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CCc1ccc([C@H](C)C(=O)Nc2ccc(CS(N)(=O)=O)cc2)cc1 ### Response: 0
ring_counting
### Instruction: Count the five-membered rings in the following molecule. O=C(Nc1cccc(Cl)c1)C1CN(S(=O)(=O)C2CC2)C1 ### Response: 0
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[NH2+]Cc1cc(C)n(-c2ccc(OC)cc2)c1C ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*][C@H](CN[5*])C(C)C Fragment 2: [1*]C(=O)C[8*] ### Response: CC(C)[C@@H](CNC(=O)CN1C(=O)c2ccccc2C1=O)N1CC[NH+](C)CC1
canonicalization
### Instruction: Canonicalize the following SMILES string. CC(c1ccc(cc1)[C@H](C)[NH2+]C[C@@H](C)[S@@](=O)C)(C)C ### Response: C[C@H]([NH2+]C[C@@H](C)[S@](C)=O)c1ccc(C(C)(C)C)cc1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)[C@@]1(C)CCCO1 Fragment 2: [5*]N(C)C1CCC(=O)CC1 ### Response: CN(C(=O)[C@@]1(C)CCCO1)C1CCC(=O)CC1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1c(O[C@H]2C[C@]([NH3+])(CCC2)C([O-])=O)ccc2c1CCC2 ### Response: [NH3+][C@]1(C(=O)[O-])CCC[C@@H](Oc2ccc3c(c2)CCC3)C1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(ccncc1)CC(=O)NNC(c1cc(C(C)C)nn1C)=O ### Response: CC(C)c1cc(C(=O)NNC(=O)Cc2ccncc2)n(C)n1
canonicalization
### Instruction: Canonicalize the following SMILES string. CC(C)NC([C@H]1CCC[C@H](NC(N[C@H](c2scc(n2)C)C2CC2)=O)C1)=O ### Response: Cc1csc([C@@H](NC(=O)N[C@H]2CCC[C@H](C(=O)NC(C)C)C2)C2CC2)n1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CNC(=O)NC(=O)[C@H](C)Sc1ncccc1Cl ### Response: 3
canonicalization
### Instruction: Canonicalize the following SMILES string. O=C(N1CCO[C@H](C1)C)C(=O)Nc1ccccc1 ### Response: C[C@H]1CN(C(=O)C(=O)Nc2ccccc2)CCO1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. COCc1cc([N+](=O)[O-])ccc1NC[C@](C)(O)c1cc(C)oc1C ### Response: 1
functional_group
### Instruction: Does the molecule contain a hydroxyl group? COc1ccnc(NC(=O)CCc2c(C)nc3c(C#N)cnn3c2C)c1 ### Response: No
functional_group
### Instruction: Does the molecule contain a aldehyde group? CC[C@@H]1CC[C@@](O)([C@@]2(C#N)COc3ccccc3C2)C1 ### Response: No
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]NCCCOC Fragment 2: [5*]NCC[8*] ### Response: COCCCNC(=O)NCCc1ncc(C)s1
functional_group
### Instruction: Does the molecule contain a ester group? N#Cc1ccc(C(=O)O[C@@H](c2ccccc2)c2nccs2)cc1 ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCOC(=O)c1c(NC(=O)CSC2=NC(=O)C3=C4CCC[C@@H]4SC3=N2)sc(C)c1C ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. C1C(=O)CC[C@]2(C=1C[C@@H]([C@@H]1[C@@H]2CC[C@]2(C)[C@H]1CC[C@@]21OC(=O)CC1)SC(C)=O)C ### Response: CC(=O)S[C@H]1CC2=CC(=O)CC[C@]2(C)[C@H]2CC[C@]3(C)[C@@H](CC[C@]34CCC(=O)O4)[C@H]12
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1cccc(N2CCN(C(=O)c3c4c(nc5ccccc35)CCC4)CC2)c1C ### Response: 1
functional_group
### Instruction: Does the molecule contain a halide group? [NH3+][C@H](c1ccc(Cl)cn1)[C@H]1CCc2cccnc21 ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@H](O)CSc1nc2c(c(=O)n(C)c(=O)n2C)n1Cc1ccccc1Cl ### Response: 3
functional_group
### Instruction: Does the molecule contain a amide group? Cc1csc(CNC(=O)[C@@H]2CC(=O)N(Cc3ccco3)C2)n1 ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1nn(C)c(C)c1CN(C)Cc1c2cccn(CC(=O)N(C)C)c-2nc1C(F)(F)F ### Response: 2
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Cc1ccc(S(=O)(=O)NCc2cnn(C)c2N)c(Br)c1 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. C1C[C@@H](NC(c2c[nH]c3ccc(cc3c2=O)OC)=O)C[C@@H]1[NH3+] ### Response: COc1ccc2[nH]cc(C(=O)N[C@@H]3CC[C@@H]([NH3+])C3)c(=O)c2c1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CCOc1ccc2c(c1)CN(c1nnc(C)s1)CC2 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [15*][C@@H]1CCCC[C@@H]1C#N Fragment 2: [5*][NH+]1CCC(C)(C)C1 ### Response: CC1(C)CC[NH+]([C@@H]2CCCC[C@@H]2C#N)C1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? NC(=O)c1cccc(CNC(=O)NCC[NH+]2CCCCC2)c1 ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [8*][C@@H](O)c1cc(OC)c(OC)cc1Br Fragment 2: [8*][C@H](O)c1cc(C)cc(F)c1 ### Response: COc1cc(Br)c([C@H](O)c2cc(C)cc(F)c2)cc1OC
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Cc1ccc(NCc2ccccc2OCC(C)C)cc1 ### Response: 0
canonicalization
### Instruction: Canonicalize the following SMILES string. C[C@@H]1C[C@@H](C)CN(C1)C(c1c2cc(Cl)ccc2nc(c1)-c1cccnc1)=O ### Response: C[C@@H]1C[C@@H](C)CN(C(=O)c2cc(-c3cccnc3)nc3ccc(Cl)cc23)C1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1ccc(NC(=O)C(=O)N2CCN(c3ccc(F)cc3)CC2)c(F)c1 ### Response: 2
ring_counting
### Instruction: Count the five-membered rings in the following molecule. N#CCCN(Cc1ccco1)C(=O)[C@@H]1C[C@H]2CC[C@@H]1O2 ### Response: 3
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)c1ccncc1F Fragment 2: [5*]N([5*])C1CCC([NH3+])CC1 ### Response: CCCN(C(=O)c1ccncc1F)C1CCC([NH3+])CC1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]CC(C)C Fragment 2: [5*]N([5*])CC ### Response: CCN(CC(C)C)C(=O)[C@H]1CCO[C@@H]1C
functional_group
### Instruction: Does the molecule contain a ether group? Cc1[nH]c(-c2ccc(OCC(=O)[O-])cc2)[nH+]c1C ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC(C)C[NH+]1CCC(NC(=O)[C@@H](C)c2ccc3ccccc3c2)CC1 ### Response: 3
functional_group
### Instruction: Does the molecule contain a ester group? Cc1nn(C)c2ncc(NC(=O)C(=O)NC3CCC(C)(C)CC3)cc12 ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. CC([C@@H](C(Nc1ccc(C)cc1)=O)Sc1nnnn1C[C@@H]1CCCO1)C ### Response: Cc1ccc(NC(=O)[C@@H](Sc2nnnn2C[C@@H]2CCCO2)C(C)C)cc1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Cc1occc1-c1nnc(SCC(=O)Nc2ccccc2C(=O)NC(C)C)n1C ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. C1CCC(N(C)C[C@H]2CN(CCO2)C)(CC1)C[NH3+] ### Response: CN1CCO[C@@H](CN(C)C2(C[NH3+])CCCCC2)C1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [14*]c1ccc([14*])o1 Fragment 2: [6*]C(N)=O ### Response: NC(=O)c1ccc(-c2cc([N+](=O)[O-])ccc2Cl)o1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COC(=O)/C=C1\S/C(=N\c2ccccc2OC)NC1=O ### Response: 2
functional_group
### Instruction: Does the molecule contain a halide group? CN(C(=O)c1cc(-c2ccccc2F)on1)c1cccc2ncccc12 ### Response: Yes
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CC[NH+](CC)[C@H]1CCN(C(=O)c2ccc(-n3cccc3)nc2)C1 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1nc(/C=C/C(=O)N[C@@H]2CCCC[C@@H]2OC2CCCC2)cs1 ### Response: 3
canonicalization
### Instruction: Canonicalize the following SMILES string. c1cc(C(OCC(c2cc([N+]([O-])=O)ccc2)=O)=O)c(cc1)Br ### Response: O=C(COC(=O)c1ccccc1Br)c1cccc([N+](=O)[O-])c1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [10*]N1C(=O)CC[C@H]1[13*] Fragment 2: [6*]C(=O)[C@H]([8*])C#N ### Response: N#C[C@H](C(=O)[C@@H]1CCC(=O)N1C(=O)c1ccc(Cl)cc1)c1nc2cc(C(F)(F)F)ccc2s1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. COc1ccc2[nH]c(=O)c(CN(Cc3cccs3)C(=O)c3cccs3)cc2c1 ### Response: 2
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CCc1cccc(C)c1NC(=O)C[NH+](CC)[C@@H](C)c1ccc(C#N)cc1 ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. c1cc(ccc1OC)[C@H](NC(c1c2n(nc1)[C@H](C(F)(F)F)C[C@H](CC)N2)=O)CC ### Response: CC[C@H]1C[C@@H](C(F)(F)F)n2ncc(C(=O)N[C@H](CC)c3ccc(OC)cc3)c2N1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N[C@@H]([8*])c1ccccc1 Fragment 2: [4*][C@H]([8*])c1cccc(F)c1 ### Response: COCCCNC(=O)N[C@H](c1ccccc1)c1cccc(F)c1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)c1cc(Br)cnc1N Fragment 2: [5*]N([5*])CC ### Response: CC[C@@H](C)CN(CC)C(=O)c1cc(Br)cnc1N
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(C)cc(nn1-c1ccc(cc1)C(=O)N[C@@H](C)c1ccccc1)C ### Response: Cc1cc(C)n(-c2ccc(C(=O)N[C@@H](C)c3ccccc3)cc2)n1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]Cc1ccccc1 Fragment 2: [5*]N1CCOC(=O)[C@H]1[13*] ### Response: Cc1ccc(NC(=O)C[C@@H]2C(=O)OCCN2Cc2ccccc2)cc1[N+](=O)[O-]
functional_group
### Instruction: Does the molecule contain a amide group? C[S@@](=O)c1c(Cl)cc(Cl)c(N)c1[N+](=O)[O-] ### Response: No
functional_group
### Instruction: Does the molecule contain a ketone group? CSc1ncc(Cl)c(C(=O)Nc2ccsc2C(=O)[O-])n1 ### Response: No
functional_group
### Instruction: Does the molecule contain a halide group? COc1cccc(S(=O)(=O)/N=C([O-])/C(C#N)=C\c2ccco2)c1 ### Response: No
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)C[4*] Fragment 2: [5*]NCc1ccccc1C ### Response: Cc1ccccc1CNC(=O)CN1CCOC[C@@H]1CC(C)C
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [16*]c1cccc(Cl)c1 Fragment 2: [15*][C@@H]1C[NH2+]C[C@H]1[15*] ### Response: COC(=O)[C@@H]1C[NH2+]C[C@H]1c1cccc(Cl)c1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CCc1cccc(S(=O)(=O)Nc2cccc(-c3nnnn3C)c2)c1 ### Response: 2
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CCn1c(SCC(=O)N(C)C2CCOCC2)nnc1-c1ccco1 ### Response: 2
functional_group
### Instruction: Does the molecule contain a halide group? N=C1/C(=C\c2cccn2-c2ccc([N+](=O)[O-])cc2)C(=O)N=C2SC(Cc3cccs3)=NN12 ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. [C@@H]([NH+](C)C[C@H](N)c1ccc(C)cc1)(CC)C ### Response: CC[C@H](C)[NH+](C)C[C@H](N)c1ccc(C)cc1
canonicalization
### Instruction: Canonicalize the following SMILES string. n1c[nH]nc1C(N1CCC[C@@H](C1)CNS(=O)(=O)C)=O ### Response: CS(=O)(=O)NC[C@H]1CCCN(C(=O)c2nc[nH]n2)C1
functional_group
### Instruction: Does the molecule contain a halide group? CSc1nc2nnc3c(=O)n(-c4cccc(Cl)c4)ccc3n2n1 ### Response: Yes
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CCO[C@H](C)C(=O)OCC(=O)NC(C)C ### Response: 0
canonicalization
### Instruction: Canonicalize the following SMILES string. N(Cc1ccc(cc1)S(=O)(=O)N)C(=O)c1ccc(OC(C)C)cc1 ### Response: CC(C)Oc1ccc(C(=O)NCc2ccc(S(N)(=O)=O)cc2)cc1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. COCCCNC(=O)Nc1cccc(C(=O)N2CCCC2)c1 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. n1c(sc(SC[C@@H]2C([NH+]=c3c(cccc3)=[NH+]2)=O)n1)NC(CCCC)=O ### Response: CCCCC(=O)Nc1nnc(SC[C@H]2[NH+]=c3ccccc3=[NH+]C2=O)s1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [16*]c1ccccc1F Fragment 2: [5*]N[C@@H]1CCCN([10*])C1=O ### Response: C[C@H](NC(=O)N[C@@H]1CCCN(c2ccccc2F)C1=O)[C@@H]1CCCO1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. O=C(COc1nc2ccccc2s1)N1CCc2ccccc2C1 ### Response: 1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. O=C([O-])COc1cccc(/C=C2/SC(=S)N(NC(=O)c3ccccc3F)C2=O)c1 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1cc2c(c(-c3nc4ccccc4s3)c1)O[C@H](CNC(=O)[C@H]1CCOC1)C2 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. n1cc(c(nc1[C@@H]1C[NH+](C)CCC1)C)C(N)=O ### Response: Cc1nc([C@H]2CCC[NH+](C)C2)ncc1C(N)=O
ring_counting
### Instruction: Count the six-membered rings in the following molecule. COc1ccc(C(=O)N2CCC(OCc3ccccc3OC)CC2)cn1 ### Response: 3
canonicalization
### Instruction: Canonicalize the following SMILES string. N(C(CCC(=O)c1cc2CCCCc2cc1)=O)Cc1nc2c(cccc2)s1 ### Response: O=C(CCC(=O)c1ccc2c(c1)CCCC2)NCc1nc2ccccc2s1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)[C@H]1CCCN1[5*] Fragment 2: [12*]S(=O)(=O)c1ccc(F)cc1 ### Response: Cc1nc(-c2ccc(CNC(=O)[C@H]3CCCN3S(=O)(=O)c3ccc(F)cc3)s2)cs1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]Nc1nccc([14*])n1 Fragment 2: [14*]c1nc(C)c2cc(OC)ccc2n1 ### Response: COc1ccc2nc(Nc3nccc(-c4cn(C)nc4C)n3)nc(C)c2c1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [10*]N1C(=O)c2ccccc2N[C@@H]1[13*] Fragment 2: [16*]c1ccc(Cl)cc1 ### Response: O=C1c2ccccc2N[C@H](c2ccc(O)c(O)c2)N1c1ccc(Cl)cc1
functional_group
### Instruction: Does the molecule contain a ether group? CCCOc1c(C[NH2+][C@H]2CCC[C@@H](C)C2)cccc1OC ### Response: Yes
ring_counting
### Instruction: Count the six-membered rings in the following molecule. C[C@H](OC(=O)C[C@H]1Sc2ccccc2NC1=O)C(=O)Nc1ccc2c(c1)OCO2 ### Response: 3
functional_group
### Instruction: Does the molecule contain a nitrile group? CCN(Cc1cn(-c2ccccc2)nc1-c1cccnc1)C[C@@H](C)C#N ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)c1cccc(F)c1Cl Fragment 2: [5*]NCc1nncn1CC ### Response: CCn1cnnc1CNC(=O)c1cccc(F)c1Cl
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [8*]CCCC Fragment 2: [9*]n1c([14*])nc(=S)c2c1CC(C)(C)OC2 ### Response: CCCCn1c(-c2ccccc2)nc(=S)c2c1CC(C)(C)OC2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC(=O)c1c(C)cc(C)c(CSc2nc3cc(S(=O)(=O)N(C)C)ccc3o2)c1C ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [8*]CCO Fragment 2: [16*]c1ccc(OC)cc1 ### Response: COc1ccc([C@H]2C(C(C)=O)=C(O)C(=O)N2CCO)cc1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCNC(=O)CN(CC)C(=O)COc1nn(C)c2nc(C)cc(C)c12 ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O[C@@H](Cc1nc2ccccc2s1)c1ccsc1 ### Response: 2
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Cc1cccc(NC(=O)CN(C)C(=O)Cc2ccccc2[N+](=O)[O-])c1C ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. c1c(c(OC(F)F)ccc1[N+](=O)[O-])NC(=O)[C@@H](NC(c1ccoc1)=O)C ### Response: C[C@H](NC(=O)c1ccoc1)C(=O)Nc1cc([N+](=O)[O-])ccc1OC(F)F
ring_counting
### Instruction: Count the five-membered rings in the following molecule. C[C@@H](NC1CC[NH+]([C@H]2CCCC[C@@H]2O)CC1)c1ccsc1 ### Response: 1