task
stringclasses
5 values
input
stringlengths
89
339
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C(c1cnc(Oc2ccccc2)cn1)N1CCC[C@H]1c1cccc(F)c1 ### Response: 1
functional_group
### Instruction: Does the molecule contain a thiol group? O=C(CSc1cccc(C(F)(F)F)c1)N1CCN(S(=O)(=O)c2cccs2)CC1 ### Response: No
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COC(=O)[C@H](C)CNC(=O)Nc1c(C)cccc1C(C)C ### Response: 3
canonicalization
### Instruction: Canonicalize the following SMILES string. N1(C(=O)N[C@@H]2C[C@@H]([NH+](C)C)CC2)CCN(CC1)Cc1ccncc1 ### Response: C[NH+](C)[C@H]1CC[C@H](NC(=O)N2CCN(Cc3ccncc3)CC2)C1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Cc1csc([C@H](C)NC(=O)CCC[NH+]2CCCCC2)n1 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [14*]c1ccccn1 Fragment 2: [4*]Cc1cnc([14*])nc1 ### Response: COCC(=O)N1CCCN(Cc2cnc(-c3ccccn3)nc2)CC1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [15*]C1CC1 Fragment 2: [5*]N(C)C[8*] ### Response: CN(Cc1nnc(C2CC2)n1C)C(=O)c1ccc(Cl)cn1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [15*]C1CCCCC1 Fragment 2: [5*]Nc1ccnn1[9*] ### Response: CN(C)C(=O)CCNC(=O)C(=O)Nc1ccnn1C1CCCCC1
canonicalization
### Instruction: Canonicalize the following SMILES string. C(c1cnccc1)(=O)NCCNC(=O)NCc1cn(-c2ccccc2)nc1 ### Response: O=C(NCCNC(=O)c1cccnc1)NCc1cnn(-c2ccccc2)c1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [14*]c1cc([14*])[nH]n1 Fragment 2: [16*]c1ccccc1 ### Response: Cc1ccsc1C(=O)N1CCCN(c2cc(-c3ccccc3)n[nH]2)CC1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCOc1ccc(N2C(=O)C[C@H](SCC(=O)Nc3cccc(Cl)c3C)C2=O)cc1 ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]NC1[C@@H]2CC3C[C@H]1CC(O)(C3)C2 Fragment 2: [1*]C(=O)c1ccc(Cl)cc1 ### Response: O=C(NC1[C@@H]2CC3C[C@H]1CC(O)(C3)C2)c1ccc(Cl)cc1
functional_group
### Instruction: Does the molecule contain a halide group? NC(=O)c1ccc(NC(=O)c2cccc(NC(=O)c3ccc(Br)o3)c2)nn1 ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)CN[5*] Fragment 2: [1*]C(=O)c1cc([14*])on1 ### Response: CC(C)(C)NC(=O)CNC(=O)c1cc(-c2ccc(Cl)s2)on1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]NCCC[8*] Fragment 2: [1*]C(=O)C[4*] ### Response: C[C@H]1CCCC[NH+]1CC(=O)NCCCc1ccccc1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [9*]n1c(=O)[nH]c2ccccc21 Fragment 2: [1*]C(=O)CN([5*])C ### Response: CC(C)NC(=O)CN(C)C(=O)Cn1c(=O)[nH]c2ccccc21
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? C=Cc1cccc(C[NH+]2CC[C@H](CNC(=O)CO)C2)c1 ### Response: Yes
functional_group
### Instruction: Does the molecule contain a carboxyl group? COC1CCN([C@H](C(=O)NC2CC2)c2ccccc2)CC1 ### Response: No
functional_group
### Instruction: Does the molecule contain a ether group? Cc1n[nH]c(C)c1[C@H]1CCC[NH+]1CC(=O)N(C)[C@@H](C)CC(C)C ### Response: No
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]NC1CC1 Fragment 2: [1*]C(=O)c1ccc[nH]1 ### Response: O=C(NC1CC1)[C@@H]1CCC[NH+](C2CCN(C(=O)c3ccc[nH]3)CC2)C1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CSc1cccc(NC(=O)C(=O)NC[C@@H](c2ccc(F)cc2)N2CC[NH+](C)CC2)c1 ### Response: 2
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Cc1ccc(-c2cc(C(=O)Nc3c(C)n(C)n(-c4ccccc4)c3=O)c3ccccc3n2)o1 ### Response: 2
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CC(C)c1ccc(CN(C)Cc2cc(=O)n(C)c(=O)n2C)cc1 ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [3*]OC(F)(F)F Fragment 2: [13*][C@H]1CSCCS1 ### Response: C[NH2+][C@H](Cc1ccc(OC(F)(F)F)cc1)[C@H]1CSCCS1
functional_group
### Instruction: Does the molecule contain a halide group? Cc1cc(F)cc([C@](C)(O)[C@@H]2CCC[NH2+]C2)c1 ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CNC(=O)C[C@H](C[NH3+])N(C)C(C)C ### Response: 4
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [16*]c1ccccc1C Fragment 2: [9*]n1nc([14*])oc1=S ### Response: Cc1ccccc1-c1nn(CN2CCCc3ccc(S(C)(=O)=O)cc32)c(=S)o1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CC[C@H](Cc1ccc(C)cc1)N(C)C(=O)Cc1nc2nc(C)cc(C)n2n1 ### Response: 2
functional_group
### Instruction: Does the molecule contain a ketone group? Cc1nn(-c2ccccc2F)c2ncc3c(c12)C(=O)N(c1ccc(C(C)C)cc1)C3=O ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. C(N1CCN(CC1)c1cc(n2nc(sc2n1)-c1ccccc1)=O)(=O)c1cccc(c1)C ### Response: Cc1cccc(C(=O)N2CCN(c3cc(=O)n4nc(-c5ccccc5)sc4n3)CC2)c1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [8*][C@H](C[NH3+])S(=O)(=O)c1ccc(F)cc1 Fragment 2: [16*]c1ccc(C)cc1 ### Response: Cc1ccc([C@H](C[NH3+])S(=O)(=O)c2ccc(F)cc2)cc1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. COC(=O)[C@H]1C[C@@H]1C(=O)N[C@@H](c1cccc(C(F)(F)F)c1)C1CC1 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. C1CC([NH+]2CCC(CC2)N(C)C(=O)[C@H]2C[C@@H](CCC2)C)CCO1 ### Response: C[C@@H]1CCC[C@@H](C(=O)N(C)C2CC[NH+](C3CCOCC3)CC2)C1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Cc1c(Cl)cccc1-n1ncnc1-c1ccc(F)cc1 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@@H]1CN(c2nccc(CN3CC[NH+]4CCC[C@@H]4C3)n2)C[C@@H](C)O1 ### Response: 1
functional_group
### Instruction: Does the molecule contain a hydroxyl group? COc1ccc([C@H](C)Nc2ccc(C(N)=O)nn2)cc1 ### Response: No
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? O=C(/C=C/c1ccco1)NNC(=O)Cc1cccc2ccccc12 ### Response: Yes
functional_group
### Instruction: Does the molecule contain a sulfonyl group? C/C=C(\C)[C@H]1C(C)=C[C@H]2CC[C@@H](OS(=O)(=O)[O-])[C@@H](C)[C@H]2[C@H]1/C=C/C=C/C(=O)[O-] ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]CC(=O)[O-] Fragment 2: [3*]OCCN[5*] ### Response: O=C([O-])COCCNC(=O)C1CCCC1
canonicalization
### Instruction: Canonicalize the following SMILES string. C1SCC[NH+](C[C@@H](COCCC23CC4CC(C3)CC(C2)C4)O)C1 ### Response: O[C@H](COCCC12CC3CC(CC(C3)C1)C2)C[NH+]1CCSCC1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. C[C@H](CCc1ccc2c(c1)OCO2)[NH2+][C@@H](CO)c1ccccc1F ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. n1c[nH]nc1[C@@H](NC(Nc1cccnc1-n1nccc1)=O)C ### Response: C[C@H](NC(=O)Nc1cccnc1-n1cccn1)c1nc[nH]n1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1nn(C)c(C)c1[C@H](OC(=O)c1cnn(C(C)C)c1C)C(F)(F)F ### Response: 3
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Cn1c(N)[n+](CC(=O)c2cccs2)c2ccccc21 ### Response: 2
functional_group
### Instruction: Does the molecule contain a hydroxyl group? CC1(C)CCC(C[NH3+])([C@H](O)c2cccc(F)c2F)CC1 ### Response: Yes
functional_group
### Instruction: Does the molecule contain a sulfonyl group? CCCCN(CC)C(=O)C[NH+](C)[C@@H]1CCS(=O)(=O)C1 ### Response: Yes
functional_group
### Instruction: Does the molecule contain a amide group? Cc1ccnc(NC(=O)CN(C)c2cc(C)c3ccccc3[nH+]2)c1 ### Response: Yes
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Cc1nc(C[NH+]2CCC(CNC(=O)N[C@@H]3CC[C@H]([NH+](C)C)C3)CC2)oc1C ### Response: 1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. O=C(Nc1sc2c(c1C(=O)N1CCN(C(=O)CCC3CCCC3)CC1)CCCC2)c1cccnc1 ### Response: 3
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCOCc1ccc(C(=O)N2CCC(O)(Cn3cc[nH+]c3C)CC2)cc1 ### Response: 2
functional_group
### Instruction: Does the molecule contain a thiol group? C[NH+](C)Cc1nc(-c2c(Cl)cccc2Cl)no1 ### Response: No
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Cc1[nH]c2ccccc2c1-c1csc(NC(=O)c2cncn2-c2ccc(F)cc2)n1 ### Response: 2
ring_counting
### Instruction: Count the five-membered rings in the following molecule. COc1cc(Cl)c(C)cc1NC(=O)c1cc([N+](=O)[O-])ccc1OC ### Response: 0
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]C1([C@@H]([8*])O)CCCC1 Fragment 2: [8*][C@H](O)c1cc(F)cc(F)c1 ### Response: O[C@H](c1cc(F)cc(F)c1)C1([NH+]2CCCCC2)CCCC1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. COc1ccc(-c2nnc(S[C@@H](C)c3ccc(F)cc3)o2)cc1OC ### Response: 1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Cc1cccc(C(=O)Nc2ccc(NC=C3C(=O)OC(C)(C)OC3=O)cc2)c1 ### Response: 3
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Cc1nn(CCO)c(C)c1C[NH2+]C[C@@H]1CCS(=O)(=O)C1 ### Response: 0
ring_counting
### Instruction: Count the five-membered rings in the following molecule. COC(=O)c1cccc(NCc2ccc(N3CCC(CO)CC3)cc2)n1 ### Response: 0
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? Cc1ccsc1[C@@H](O)C1(c2ccccc2)CCC1 ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@@H]1CCN(C(=O)Nc2ccccc2N2CCCCCC2)C[C@@H]1O ### Response: 1
functional_group
### Instruction: Does the molecule contain a amide group? CCC1(CNC(=O)NC[C@H](c2cccs2)[NH+]2CCCC2)CC1 ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCC[C@@H]1[C@@H](C)CCCN1C(=O)c1cc2c(cc1O)OCO2 ### Response: 3
canonicalization
### Instruction: Canonicalize the following SMILES string. o1c(C)c(c(C)n1)CCC(=O)Nc1nc(cs1)-c1cc2CC(Nc2cc1)=O ### Response: Cc1noc(C)c1CCC(=O)Nc1nc(-c2ccc3c(c2)CC(=O)N3)cs1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1cc([N+]([O-])=O)c(OCC)cc1N1CCSCC1 ### Response: CCOc1cc(N2CCSCC2)ccc1[N+](=O)[O-]
ring_counting
### Instruction: Count the five-membered rings in the following molecule. C[C@@H](CC(=O)NN)Sc1ccncc1 ### Response: 0
canonicalization
### Instruction: Canonicalize the following SMILES string. O=C(OCC1(C)COC1)Cc1c2cc(c(C)cc2oc1)C ### Response: Cc1cc2occ(CC(=O)OCC3(C)COC3)c2cc1C
functional_group
### Instruction: Does the molecule contain a carboxyl group? Cc1cc(C)n(CC(=O)N2CCC([C@H](O)Cc3ccccc3)CC2)c(=O)n1 ### Response: No
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Cc1cc(C(=O)COc2ccc3c(c2)OCCO3)c(C)n1Cc1ccccc1 ### Response: 3
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@H](C[NH2+]C1CCCCC1)C(N)=O ### Response: 3
canonicalization
### Instruction: Canonicalize the following SMILES string. CS(=O)(c1cccc(c1[N+]([O-])=O)N[C@H](c1ccccc1Cl)C)=O ### Response: C[C@H](Nc1cccc(S(C)(=O)=O)c1[N+](=O)[O-])c1ccccc1Cl
functional_group
### Instruction: Does the molecule contain a sulfonyl group? CCOc1ccc(NC(=O)N(C)Cc2csc(Br)c2)cc1 ### Response: No
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]Cc1nccn1C Fragment 2: [5*]N([5*])S(=O)(=O)c1cc(Cl)ccc1Cl ### Response: Cn1ccnc1CN(C1CC1)S(=O)(=O)c1cc(Cl)ccc1Cl
ring_counting
### Instruction: Count the six-membered rings in the following molecule. S=C(Nc1ccccc1Cl)N1CCCC[C@H]1c1cccnc1 ### Response: 3
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CSCc1cc(NC(=O)CN2CCCOC2=O)ccc1Cl ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. c1c2OCOc2cc(/C=C2\Oc3c(C2=O)ccc(OCC(N[C@H](CO)C)=O)c3)c1 ### Response: C[C@@H](CO)NC(=O)COc1ccc2c(c1)O/C(=C\c1ccc3c(c1)OCO3)C2=O
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COc1ccc(OC)c([C@@H]2C[C@H](C(=O)N3CCC4(CC3)OCCO4)N(C)S(=O)(=O)N2)c1 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC[C@H](Cc1ccc(C)cc1)N(C)C(=O)Cc1nc2nc(C)cc(C)n2n1 ### Response: 4
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CC1(C)C[NH+](C[C@@H](O)COCc2ccco2)C1(C)C ### Response: 0
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*][NH+]1CCCCC1 Fragment 2: [4*]C[C@H]([4*])C ### Response: Cc1cc(N[C@H](C)C[NH+]2CCCCC2)[nH+]cc1N
ring_counting
### Instruction: Count the six-membered rings in the following molecule. O=C([O-])c1cc(C2CC2)nc2c(-c3ccc(Cl)cc3)cnn12 ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*][N-]c1ccc([16*])cc1 Fragment 2: [12*]S(=O)(=O)c1cc(F)ccc1F ### Response: O=S(=O)([N-]c1ccc(-c2ccc3nncn3n2)cc1)c1cc(F)ccc1F
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@@H]1CSCCN1C(=O)Cl ### Response: 1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Cc1cscc1C[NH2+][C@H]1CS[C@H](C)C1 ### Response: 0
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(C(C)C)ccc(cc1)[C@@H]1[C@@H](/C([O-])=C(/C#N)C(=O)NC(C)C)C1 ### Response: CC(C)NC(=O)/C(C#N)=C(/[O-])[C@H]1C[C@@H]1c1ccc(C(C)C)cc1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C(NCC1CCOCC1)[C@H]1CC(C(c2ccccc2)c2ccccc2)=NO1 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. [C@H]1(CN(S(=O)(=O)c2cccc(c2)C(NCCOc2ccccc2)=O)C[C@H](C1)C)C ### Response: C[C@H]1C[C@H](C)CN(S(=O)(=O)c2cccc(C(=O)NCCOc3ccccc3)c2)C1
functional_group
### Instruction: Does the molecule contain a nitro group? CCN(C[C@H]1CCOC1)C(=O)c1cc(C)n(-c2ccc(OC)cc2)n1 ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. s1c(Cl)c(CSc2ncccc2)nn1 ### Response: Clc1snnc1CSc1ccccn1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Clc1ccnc(C[NH+]2CCC(C[NH+]3CCCC3)CC2)c1 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)C1=C(C)Nc2nnnn2[C@H]1c1ccc(F)c(F)c1 Fragment 2: [3*]OC(C)(C)C ### Response: CC1=C(C(=O)OC(C)(C)C)[C@H](c2ccc(F)c(F)c2)n2nnnc2N1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N(C)[C@H]1CC[NH+](CC)C[C@H]1C Fragment 2: [1*]C(=O)[C@@H]1Cc2cc(C)c(C)cc2O1 ### Response: CC[NH+]1CC[C@H](N(C)C(=O)[C@@H]2Cc3cc(C)c(C)cc3O2)[C@H](C)C1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? NS(=O)(=O)C[C@@H]1CCCN(C(=O)CCc2ccccc2Cl)C1 ### Response: 3
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N[C@@H]([8*])CC Fragment 2: [3*]Oc1cccc(Cl)c1 ### Response: CC[C@H](Oc1cccc(Cl)c1)C(=O)N[C@H](CC)c1ccc(C)cc1
canonicalization
### Instruction: Canonicalize the following SMILES string. c12c([O-])n[nH]c(c1c(ccc2)N[C@@H]1CC[NH2+]C1)=O ### Response: O=c1[nH]nc([O-])c2cccc(N[C@@H]3CC[NH2+]C3)c12
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N[C@@H]([8*])c1ccccc1 Fragment 2: [5*]N[C@H]([8*])C1CCCC1 ### Response: O=C(NCc1nnc2n1CCCCC2)N[C@H](c1ccccc1)C1CCCC1
functional_group
### Instruction: Does the molecule contain a nitrile group? CCc1c(Cl)cc(N)c(O)c1Cl ### Response: No
ring_counting
### Instruction: Count the six-membered rings in the following molecule. C=CCN(Cc1ccc(C#N)cc1)[C@H]1CCN(CC(F)(F)F)C1=O ### Response: 1
functional_group
### Instruction: Does the molecule contain a amine group? C[C@@H]1CCO[C@H]1C(=O)Nc1nc2c(cc1C#N)CCC2 ### Response: No
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [14*]c1ccc2ccccc2n1 Fragment 2: [16*]c1ccc(SC)cc1 ### Response: CSc1ccc([C@H](Cl)Cc2ccc3ccccc3n2)cc1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [8*]Cc1nnc(S[11*])n1C Fragment 2: [11*]Sc1nnc([14*])n1C ### Response: Cc1nc2c(C)cccn2c(=O)c1Cc1nnc(SCC(=O)NC(C)C)n1C