task
stringclasses
5 values
input
stringlengths
89
339
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1ccc([C@@H](NC(=O)NCCO)c2ccccc2)cc1 ### Response: 2
functional_group
### Instruction: Does the molecule contain a ketone group? CCOc1cccc(CNC(=O)[C@H]2CCO[C@H]2C)c1OC(F)F ### Response: No
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Cc1ccc([C@H]2Nn3c(C)nnc3S[C@H]2C(=O)NCc2ccco2)cc1 ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)c1c(C)nc([O-])nc1SC Fragment 2: [16*]c1ccccc1 ### Response: CSc1nc([O-])nc(C)c1C(=O)N[C@H](C)[C@H](C)c1ccccc1
functional_group
### Instruction: Does the molecule contain a halide group? O=c1cc(-c2ccccc2)[nH]n1-c1ccc(Br)cc1 ### Response: Yes
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Cn1ccnc1[C@@H](O)[C@@H]1CCC[NH+](C2CCC(C)(C)CC2)C1 ### Response: 1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. O=C1CCCc2cc(Br)ccc21 ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [15*][C@H]1/C(=C(\[O-])OCC)C(=O)N=C(SC)[C@H]1C#N Fragment 2: [16*]c1ccccc1OC ### Response: CCO/C([O-])=C1\C(=O)N=C(SC)[C@@H](C#N)[C@H]1c1ccccc1OC
canonicalization
### Instruction: Canonicalize the following SMILES string. C1([C@@](NC(N1[C@H](C(Nc1cc(Cl)ccc1OC)=O)C)=O)(C)c1cc2CCCc2cc1)=O ### Response: COc1ccc(Cl)cc1NC(=O)[C@H](C)N1C(=O)N[C@](C)(c2ccc3c(c2)CCC3)C1=O
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Cc1cc2ncn(C[C@@H](O)COc3c(C)ccc(C)c3C)c2cc1C ### Response: 1
functional_group
### Instruction: Does the molecule contain a amide group? CN(CCc1cccs1)C(=O)C(=O)Nc1cc(CC(C)(C)C)nn1C ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. Cc1cc(NCc2nnc(C(C)(C)C)o2)ccc1C ### Response: Cc1ccc(NCc2nnc(C(C)(C)C)o2)cc1C
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)CCN[5*] Fragment 2: [5*]N[C@@H](C)C(C)(C)C ### Response: COC(=O)NCCC(=O)N[C@@H](C)C(C)(C)C
functional_group
### Instruction: Does the molecule contain a ketone group? Cc1c(-c2ccc(F)cc2)nn2c1N=C(O)C[C@H]2C(=O)Nc1ccccc1 ### Response: No
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Cc1cc(F)ccc1-c1cc(NCc2ccccn2)nc2[nH]ccc12 ### Response: 1
functional_group
### Instruction: Does the molecule contain a aldehyde group? O=C(NC[C@H]1N=NC2=C1CCCCC2)[C@H]1CC=CCC1 ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. n1oc(cc1NC(CSCC(N[C@@H](C)C1CC1)=O)=O)C ### Response: Cc1cc(NC(=O)CSCC(=O)N[C@@H](C)C2CC2)no1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [8*]C[C@H]1CCCO1 Fragment 2: [5*]Nc1ccc2c(c1)OCO2 ### Response: C[C@H](Sc1nnc(-c2ccc(Cl)cc2)n1C[C@H]1CCCO1)C(=O)Nc1ccc2c(c1)OCO2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C#Cc1cc(F)c(NC(=O)NCc2cccc(-c3ccccn3)c2)c(F)c1 ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [7*]C(C)C Fragment 2: [4*][C@H](C)CCC[7*] ### Response: CC(C)=CCC[C@@H](C)[NH2+]C[C@]1(O)CCOC1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C(CSc1cccc(C(F)(F)F)c1)N1CCN(S(=O)(=O)c2cccs2)CC1 ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. S1/C(=C\c2cccc(C)c2)C(N(C1=S)c1c(C)cccc1C)=O ### Response: Cc1cccc(/C=C2\SC(=S)N(c3c(C)cccc3C)C2=O)c1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC[C@H](CS)C[NH+](C)Cc1ccccc1OC ### Response: 4
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [9*]n1cnc2c(=O)[nH]c(N)nc21 Fragment 2: [13*][C@H]1O[C@H](CO)[C@@H](O)[C@H]1OC ### Response: CO[C@@H]1[C@H](O)[C@@H](CO)O[C@@H]1n1cnc2c(=O)[nH]c(N)nc21
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Cc1cnn(CC[NH2+]C[C@@H](O)c2ccc(C(F)(F)F)cc2)c1 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=c1c2ccccc2nc(SCc2cccnc2)n1C1CCCCC1 ### Response: 1
functional_group
### Instruction: Does the molecule contain a thiol group? Cc1nccc(C(=O)N2CCC[NH+](Cc3cnn(C(C)C)c3)CC2)n1 ### Response: No
functional_group
### Instruction: Does the molecule contain a amide group? Cc1cc(C)c2sc(N(Cc3ccco3)C(=O)c3cccc(S(=O)(=O)C(C)C)c3)nc2c1 ### Response: Yes
ring_counting
### Instruction: Count the six-membered rings in the following molecule. COC(=O)CNC(=O)c1sc2ncn(CC(=O)N3CCCCC3)c(=O)c2c1C ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. C(C(c1sccc1Br)=O)[S@](=O)c1cccc(F)c1 ### Response: O=C(C[S@](=O)c1cccc(F)c1)c1sccc1Br
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [14*]c1cccs1 Fragment 2: [16*]c1ccccc1F ### Response: C[C@H](Cc1cccs1)N(C)C(=O)[C@@H]1C[C@@H]1c1ccccc1F
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(NC2CC2)sc(SCc2[nH]c(=O)c3c(n2)sc(C)c3C)nn1 ### Response: Cc1sc2nc(CSc3nnc(NC4CC4)s3)[nH]c(=O)c2c1C
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1ccc(NC(=O)C[NH+]2CCC[C@H]2C)cc1NC(=O)C[NH+]1CCCCC1 ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCCCC1=NC(=O)C2=C3CCCC[C@@H]3SC2=N1 ### Response: 4
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC(=O)NCc1cnc([C@@H]2CCCN2CC(=O)Nc2nccs2)cc1C(F)(F)F ### Response: 2
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Cc1ccc(F)cc1NC(=O)C(=O)NCCCn1cc[nH+]c1 ### Response: 1
functional_group
### Instruction: Does the molecule contain a amine group? O=C(COc1ncnc2ccc(Br)cc12)Nc1ccccc1Cl ### Response: No
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)c1cccc(OC)n1 Fragment 2: [5*]NC[C@]1([O-])CC[C@H]1[15*] ### Response: CCS[C@@H]1CC[C@@]1([O-])CNC(=O)c1cccc(OC)n1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]Nc1cccc([16*])c1 Fragment 2: [16*]c1ccoc1 ### Response: COC(=O)c1cccc(NCc2noc(-c3ccoc3)n2)c1
canonicalization
### Instruction: Canonicalize the following SMILES string. C[C@H](c1nc2c(s1)cccc2)N(CC(=O)[O-])CC#C ### Response: C#CCN(CC(=O)[O-])[C@H](C)c1nc2ccccc2s1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N1CCOCC1 Fragment 2: [16*]c1ccc(Br)cc1 ### Response: C[C@H](CCc1ccc(Br)cc1)NC(=O)c1cccc(S(=O)(=O)N2CCOCC2)c1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Fc1cnc2[nH]cc(I)c2c1I ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [8*]C[C@@]1([13*])NC(=O)N([10*])C1=O Fragment 2: [8*]Cc1ccc(F)cc1 ### Response: COCCN1C(=O)N[C@@](Cc2ccc(F)cc2)(C2CCN(C(=O)c3ccc(C)cc3)CC2)C1=O
functional_group
### Instruction: Does the molecule contain a ether group? CCc1ccc(N2N=C(C)/C(=C\c3ccc(-c4ccc5c(c4)C(=O)OC5)o3)C2=O)cc1 ### Response: Yes
functional_group
### Instruction: Does the molecule contain a nitro group? CC[C@@H](C)[C@@H](O)CSc1cccc(Br)c1 ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. C(C)C[C@@H]1[C@@H](CC[NH+]1Cc1ccccc1)C[C@H](c1ccccc1)O ### Response: CCC[C@@H]1[C@H](C[C@@H](O)c2ccccc2)CC[NH+]1Cc1ccccc1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CC(C)[C@@H](Sc1nnnn1C1CC1)C(=O)N(C)c1ccccc1 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. C(c1c(C)ccc(c1)N)(=O)N(CC(C)C)C(CC)CC ### Response: CCC(CC)N(CC(C)C)C(=O)c1cc(N)ccc1C
ring_counting
### Instruction: Count the six-membered rings in the following molecule. O[C@H](CNc1ncnc2sc3c(c12)CCNC3)c1ccccc1 ### Response: 3
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COC(=O)c1ccc(CSCCO)nc1 ### Response: 2
functional_group
### Instruction: Does the molecule contain a amide group? CC(C)c1ccc(-n2ncc3c(=O)n(CC(=O)NC4CCCC4)cnc32)cc1 ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]CC[C@@H]1CCCC1=O Fragment 2: [3*]OCC[8*] ### Response: O=C1CCC[C@H]1CCOc1cncc(Cl)c1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O[C@@H](c1ccc(Cl)s1)C1([NH+]2CCCC2)CCCC1 ### Response: 1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. COC(=O)/C=C/C(=O)Nc1cc(C)cc(C)c1 ### Response: 0
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COC(=O)c1cccc(NC(=O)c2c(-c3ccccc3)noc2C)c1 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. O=C([C@@H]1[C@H]([C@@H]2CC[C@H]1O2)C([O-])=O)N1CCN(c2cc(Cl)ccc2)CC1 ### Response: O=C([O-])[C@@H]1[C@@H](C(=O)N2CCN(c3cccc(Cl)c3)CC2)[C@H]2CC[C@@H]1O2
functional_group
### Instruction: Does the molecule contain a ether group? C[NH+]1[C@@H]2CC[C@H]1CC(NC(=O)Cc1ccccc1F)C2 ### Response: No
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [16*]c1c(F)cccc1Br Fragment 2: [4*]C[C@@H](C)N[5*] ### Response: C[C@H](C[NH+]1CCCCC1)NC(=O)Nc1c(F)cccc1Br
functional_group
### Instruction: Does the molecule contain a amine group? C[NH+](C)[C@H]1CC[C@H](NC(=O)C(=O)Nc2ccc(F)cc2F)C1 ### Response: No
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COc1ccc(C(C)(C)C)cc1N[C@@H](C)C(=O)Nc1ccc(NC(C)=O)cc1 ### Response: 3
functional_group
### Instruction: Does the molecule contain a ether group? COc1ccc(NC(=O)CC[C@@H]2CCCN(C(=O)CNC(C)=O)C2)c(C)c1 ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. N1(CC2=C([C@@H](NC(=O)N2C)c2ccc(cc2)Br)C1=O)c1ccc(cc1)C(OCC)=O ### Response: CCOC(=O)c1ccc(N2CC3=C(C2=O)[C@H](c2ccc(Br)cc2)NC(=O)N3C)cc1
canonicalization
### Instruction: Canonicalize the following SMILES string. C(NC(CC)(C#C)CC)(=O)CSc1n(nnn1)-c1ccc(C)cc1 ### Response: C#CC(CC)(CC)NC(=O)CSc1nnnn1-c1ccc(C)cc1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(cc(O[C@@H](C)C(=O)N2C[C@H](CC2)COCC)cc(c1)Cl)Cl ### Response: CCOC[C@H]1CCN(C(=O)[C@H](C)Oc2cc(Cl)cc(Cl)c2)C1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCc1cccc(C)c1NC(=O)C[C@H]1C[NH2+]CCO1 ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(F)cccc(F)c1N1CC[C@H](C1)N[C@@H]1[C@H](C[NH+](C(C)C)C1)C ### Response: CC(C)[NH+]1C[C@H](N[C@@H]2CCN(c3c(F)cccc3F)C2)[C@@H](C)C1
functional_group
### Instruction: Does the molecule contain a ether group? Cc1noc(-c2ccc(C(=O)NNC(=S)N[C@@H](C)C3CC3)cc2)n1 ### Response: No
ring_counting
### Instruction: Count the five-membered rings in the following molecule. O=C(c1ccc(OC2CC[NH+](CCc3ccccc3)CC2)cc1)N1CCC[C@H]1CO ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. S(Cc1c(noc1C)C)c1c(C(=O)N2C[C@@H](CCC2)O)cccn1 ### Response: Cc1noc(C)c1CSc1ncccc1C(=O)N1CCC[C@@H](O)C1
functional_group
### Instruction: Does the molecule contain a hydroxyl group? COc1ccccc1C[NH+](C)[C@H]1CCC[C@@H]1SC ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. C(C)(N(c1ccc(cc1F)NC(Nc1cnn(c1)CC(F)F)=O)C)C ### Response: CC(C)N(C)c1ccc(NC(=O)Nc2cnn(CC(F)F)c2)cc1F
canonicalization
### Instruction: Canonicalize the following SMILES string. C1C2CC3CC1CC(C3)(C2)C(=O)NCCC(=O)N[C@H]1CN(C(=O)CC1)C ### Response: CN1C[C@H](NC(=O)CCNC(=O)C23CC4CC(CC(C4)C2)C3)CCC1=O
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]Cc1nc([C@@H]([4*])C)no1 Fragment 2: [3*]OCC ### Response: CCO[C@@H](C)c1noc(CN2CC[NH+]([C@H]3CCCc4ccccc43)CC2)n1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. COC(=O)c1ccc(C[NH2+][C@@H]2CCCC[C@H]2C(F)(F)F)[nH]1 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1scc(C(=O)N2CCC[C@H]([C@@H]3C[C@H](C(F)F)n4ncnc4N3)C2)c1C ### Response: 1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. O[C@H](Cc1ccc(OC(F)(F)F)cc1)c1ccc(F)cn1 ### Response: 2
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Cc1cc(CN(Cc2ccccc2)C[C@@H](O)c2ccco2)on1 ### Response: 1
functional_group
### Instruction: Does the molecule contain a amine group? Cc1cnc(C(C)(C)NC(=O)CCc2ccco2)s1 ### Response: No
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)c1sc([14*])cc1OC Fragment 2: [16*]c1ccccc1 ### Response: COc1cc(-c2ccccc2)sc1C(=O)NCc1nc2ccccc2[nH]1
canonicalization
### Instruction: Canonicalize the following SMILES string. O(Cc1sccc1)C[C@H](Cn1ncc2c(c1=O)cccc2)O ### Response: O=c1c2ccccc2cnn1C[C@H](O)COCc1cccs1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CSCC[C@@H](C)N(C)C(=O)NCc1cc(Cl)c2c(c1)OCCO2 ### Response: 4
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]C[C@H]1CCC[NH+](C)C1 Fragment 2: [5*][NH2+]C[C@H](CC)CCO ### Response: CC[C@H](CCO)C[NH2+]C[C@H]1CCC[NH+](C)C1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Cc1ccc(C#N)cc1S(=O)(=O)[N-]c1ccc(Cl)cc1 ### Response: 2
ring_counting
### Instruction: Count the five-membered rings in the following molecule. C[C@@H](SCc1ccccc1)C(=O)Nc1ccc(OC2CC[NH+](C)CC2)cc1 ### Response: 0
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N[C@@H]([8*])CC Fragment 2: [1*]C(=O)[C@@H]1CC[C@H](C[NH3+])O1 ### Response: CC[C@@H](NC(=O)[C@@H]1CC[C@H](C[NH3+])O1)c1ccc(C)cc1
functional_group
### Instruction: Does the molecule contain a ether group? Cc1nc(N2CCC[C@@H](C(=O)NCC3CC3)C2)c2cc[nH]c2n1 ### Response: No
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [3*]OC[C@H](C#N)C[8*] Fragment 2: [16*]c1ccccc1 ### Response: C[C@@H]1c2ccccc2O[C@@H]1C(=O)OC[C@H](C#N)Cc1ccccc1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COc1ccccc1NC1CC[NH+](Cc2ccc([N+](=O)[O-])cc2)CC1 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@H]1CC(C(=O)N2CCCC[C@@H]2c2ncc(-c3cccc(F)c3)[nH]2)C[C@H](C)O1 ### Response: 1
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? COc1ccc(C[NH+](C)CC(N)=O)c(OC)c1 ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. O=S(c1cc(C(NC23CC4CC(C3)CC(C2)C4)=O)ccc1)(=O)Nc1ccc(cc1)OC ### Response: COc1ccc(NS(=O)(=O)c2cccc(C(=O)NC34CC5CC(CC(C5)C3)C4)c2)cc1
functional_group
### Instruction: Does the molecule contain a hydroxyl group? Cc1ccc(/C=C/C(=O)N2CC[C@H](C(N)=O)c3ccccc32)o1 ### Response: No
functional_group
### Instruction: Does the molecule contain a amide group? C[C@@H]1N=C2c3ccccc3N=C(SCC(=O)Nc3ccccc3Cl)N2C1=O ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC(=O)Nc1c(C)nn(-c2ccc(Cl)cc2)c1N1CCC(C(=O)NCCc2ccccc2)CC1 ### Response: 2
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CCC[C@@H](CS)C[NH+](C)Cc1ccncc1 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1cc(ccc1OC)NC(=O)Nc1ccccc1CC ### Response: CCc1ccccc1NC(=O)Nc1ccc(OC)cc1
canonicalization
### Instruction: Canonicalize the following SMILES string. C1[C@@H](N(C(=O)c2ccccc2OC)c2ccc(cc2)C)CS(C=1)(=O)=O ### Response: COc1ccccc1C(=O)N(c1ccc(C)cc1)[C@@H]1C=CS(=O)(=O)C1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CC[C@H](Oc1cccc(Cl)c1)C(=O)N[C@H](CC)c1ccc(C)cc1 ### Response: 2
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CC(C)C[C@@H]1N[C@]2(C(=O)N(Cc3ccccc3F)c3ccccc32)[C@@H]2C(=O)N(C)C(=O)[C@H]12 ### Response: 3
canonicalization
### Instruction: Canonicalize the following SMILES string. C1[C@@H](CN(Cc2csc(n2)-c2ccco2)C[C@@H]1C)[NH3+] ### Response: C[C@@H]1C[C@H]([NH3+])CN(Cc2csc(-c3ccco3)n2)C1