task
stringclasses
5 values
input
stringlengths
89
339
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]Nc1ccc([S@@](C)=O)c(F)c1 Fragment 2: [5*]N1CCC[C@@H](O)C1 ### Response: C[S@@](=O)c1ccc(NC(=O)N2CCC[C@@H](O)C2)cc1F
ring_counting
### Instruction: Count the six-membered rings in the following molecule. COc1cc(OC)cc([C@@H](N[C@@H](C)c2ccc(F)cn2)c2[nH+]ccn2C)c1 ### Response: 2
ring_counting
### Instruction: Count the six-membered rings in the following molecule. C[C@@H](CNC(=O)c1ccc(Cl)c(-n2cnc3cccnc32)c1)c1ccccc1 ### Response: 3
canonicalization
### Instruction: Canonicalize the following SMILES string. C(=O)(c1ccc(NC(=O)C)cc1)N1CCC(Cn2cc[nH+]c2)CC1 ### Response: CC(=O)Nc1ccc(C(=O)N2CCC(Cn3cc[nH+]c3)CC2)cc1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Cc1nc(-c2cccc(C(=O)Nc3cnn(C[C@H]4CCCO4)c3)c2)cs1 ### Response: 3
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? CCCc1nc([C@H](NC(=O)c2ccsc2)c2ccccc2)no1 ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(cc(c(cc1)F)F)CN1[C@H](C[NH+](CC1)Cc1c(F)cc(F)cc1)CCO ### Response: OCC[C@H]1C[NH+](Cc2ccc(F)cc2F)CCN1Cc1ccc(F)c(F)c1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C1CCCCN1C1CC[NH+](Cc2cc(C(F)(F)F)ccc2Cl)CC1 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. C(CC[NH2+][C@@H]1CC2(CCOCC2)OCC1)C(=O)[O-] ### Response: O=C([O-])CCC[NH2+][C@H]1CCOC2(CCOCC2)C1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1c(cc(cc1C[NH2+]CC(C)C)OC)F ### Response: COc1cc(F)cc(C[NH2+]CC(C)C)c1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. C[C@@H]1C[NH2+]CCN1CC(F)(F)F ### Response: 0
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [9*]n1cccn1 Fragment 2: [1*]C(=O)C([1*])=O ### Response: CC(C)[C@H](C)NC(=O)C(=O)Nc1cc(Br)ccc1-n1cccn1
functional_group
### Instruction: Does the molecule contain a amine group? CN1C(=O)CC[C@H](N[C@H]2CCC[C@@H]2[C@@H]2CCC[NH2+]2)C1=O ### Response: Yes
ring_counting
### Instruction: Count the six-membered rings in the following molecule. COC(=O)[C@H]1CN(C(=O)c2sc(C)nc2C)C[C@H]1C ### Response: 0
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1ccc(NC(=O)CCc2cnn(C)c2C)cc1S(C)(=O)=O ### Response: 3
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*][C@@H]([8*])C(N)=O Fragment 2: [5*][NH2+][C@@H]1CCc2cc(F)ccc21 ### Response: NC(=O)[C@@H]([NH2+][C@@H]1CCc2cc(F)ccc21)c1ccccc1
functional_group
### Instruction: Does the molecule contain a ketone group? COc1ncccc1CNC(=O)N[C@@H]1C[C@H]2CCCc3cccc1c32 ### Response: No
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CC(=O)N1CCc2cc(S(=O)(=O)Oc3ccccc3Cl)ccc21 ### Response: 1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CC(C)c1cc(C(=O)N(C)CCOc2ccccc2)on1 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N1CCC([15*])CC1 Fragment 2: [4*]Cc1nnc([14*])n1[9*] ### Response: Cn1nccc1C(=O)N1CCC(c2nnc(C[NH+](C)C)n2C2CC2)CC1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COc1cc2c(cc1C[NH+]1C[C@@H]3CC[C@@](O)(c4ncccc4C)[C@@H]3C1)CCCC2 ### Response: 1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CCN(C(=O)c1ccc(Cl)cc1Cl)[C@@H]1CCS(=O)(=O)C1 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C(CSc1ncccn1)Nc1cccc(Br)c1 ### Response: 2
ring_counting
### Instruction: Count the six-membered rings in the following molecule. C[C@@H](C[NH+]1CCC(Cn2cc(CNC(N)=O)nn2)CC1)c1ccccc1 ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. c1cc(C)cc(c1CNC(=O)Nc1ccn(n1)C)N(C)C ### Response: Cc1ccc(CNC(=O)Nc2ccn(C)n2)c(N(C)C)c1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC(C)[C@]1(C[C@@H]2Cc3ccccc32)CCCCC[NH2+]1 ### Response: 3
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Br[C@H]1CCC[C@@H]1C[C@H]1COc2ccccc21 ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COc1ccc2c(c1OC)C(=O)O[C@H]2[C@H]1c2cc3c(cc2CCN1C)OCO3 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. O=C(C(=O)Nc1ccc(OC)cc1Cl)NCCCn1ccc2c1cccc2 ### Response: COc1ccc(NC(=O)C(=O)NCCCn2ccc3ccccc32)c(Cl)c1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C(Cn1ccc2ccccc21)NC[C@@H]1CCS(=O)(=O)C1 ### Response: 2
functional_group
### Instruction: Does the molecule contain a hydroxyl group? CC(C)[NH2+][C@@](C)(CO)CN(C)C[C@@H]1CCC[NH+]1C ### Response: Yes
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CCC(CC)[NH2+]CC(=O)Nc1ccc(N(C)C)cc1 ### Response: 0
canonicalization
### Instruction: Canonicalize the following SMILES string. c1cc(ccc1OC)-c1onc(n1)Cn1c(=O)cccc1 ### Response: COc1ccc(-c2nc(Cn3ccccc3=O)no2)cc1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*][NH2+][C@H](C)CCCO Fragment 2: [4*]Cc1csc([14*])n1 ### Response: C[C@H](CCCO)[NH2+]Cc1csc(-c2ccc(F)cc2)n1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. C=C[C@@]1(C)CC(=O)[C@]2(O)[C@@]3(C)CCCC(C)(C)[C@@H]3[C@H](O)[C@H](O)[C@@]2(C)O1 ### Response: 3
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? CC[C@H](C)[C@@H](NC(=O)c1ccc(=O)[nH]c1)c1nc2ccccc2[nH]1 ### Response: Yes
ring_counting
### Instruction: Count the six-membered rings in the following molecule. O[C@H]1CN(Cc2ccc(Cl)s2)Cc2ccccc21 ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]Cc1nnnn1[9*] Fragment 2: [16*]c1ccccc1 ### Response: C[NH+]1CCN(C(=O)CCCn2nnnc2C[NH+]2CCOCC2)C[C@H]1c1ccccc1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [8*]C(C)(C)C Fragment 2: [15*]C1CCC([15*])(C#N)CC1 ### Response: CC(C)(C)C1CCC(C#N)(C(C)(C)O)CC1
canonicalization
### Instruction: Canonicalize the following SMILES string. O=C(NCCC)CSc1nnc(n1C)-c1ccc(C(C)(C)C)cc1 ### Response: CCCNC(=O)CSc1nnc(-c2ccc(C(C)(C)C)cc2)n1C
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? CCn1c(=O)c(=O)[nH]c2cc(C(=O)Nc3ccc(C(C)C)cc3)ccc21 ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N1CCCC[C@H]1[13*] Fragment 2: [14*]c1noc([14*])n1 ### Response: CCC(=O)N1CCCC[C@H]1c1nc(-c2ccncc2)no1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. O=C([O-])COc1ccc(/C=C2\C(=O)N(c3ccc(Cl)cc3Cl)C(=O)N=C2[O-])cc1Cl ### Response: 0
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N1CCO[C@H]([13*])C1 Fragment 2: [4*]CCS(C)(=O)=O ### Response: CS(=O)(=O)CCN1CCO[C@H](c2ccc(Cl)s2)C1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]Nc1cnccc1C Fragment 2: [5*]Nc1ccc(C)cc1 ### Response: Cc1ccc(NS(=O)(=O)c2ccc(C(=O)Nc3cnccc3C)cc2)cc1
functional_group
### Instruction: Does the molecule contain a ester group? COCCCN(C)C(=O)C(=O)Nc1nnc(C23CC4CC(CC(C4)C2)C3)s1 ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. [nH]1c(c(C(=O)N[C@@H](C)C(OCCCC)=O)cc2CCCCc12)=O ### Response: CCCCOC(=O)[C@H](C)NC(=O)c1cc2c([nH]c1=O)CCCC2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCCCOCC(=O)N1CCO[C@]2(C[NH2+]CCOC2)C1 ### Response: 4
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CC(C)[NH+]1CCN(Cc2cc3n(n2)CCN(C(=O)c2ncn[n-]2)C3)C[C@H]1C ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. C1CCO[C@@H]1CNC(=O)c1cc2cc(ccc2o/c1=[NH+]\c1ccccc1C)Cl ### Response: Cc1ccccc1/[NH+]=c1\oc2ccc(Cl)cc2cc1C(=O)NC[C@@H]1CCCO1
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? CC(=O)C1=C(C)C(C(=O)CSc2nc3ccccc3o2)=N[C@H]1C ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. C1Cc2n(ncc2[C@@H]([NH2+]C[C@@]2(CCc3ccccc32)O)C1)C ### Response: Cn1ncc2c1CCC[C@@H]2[NH2+]C[C@]1(O)CCc2ccccc21
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@H](OC(=O)c1nc(C2CC2)n2ccccc12)c1cnc2ccccc2c1 ### Response: 2
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? Cn1cncc1C(=O)N1CCc2[nH]nc(-c3ccc(-c4ccccc4)cc3)c2C1 ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(ccc(S(=O)(=O)N2C[C@H](CCC2)C(OCC(F)(F)F)=O)s1)C ### Response: Cc1ccc(S(=O)(=O)N2CCC[C@H](C(=O)OCC(F)(F)F)C2)s1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. COCCCN1C(=O)c2ccc(C(=O)Nc3c(C)cc(C)cc3Cl)cc2C1=O ### Response: 1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. O=C(S[C@H]1CS(=O)(=O)C[C@@H]1Cl)c1ccc([N+](=O)[O-])cc1 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]Nc1cnc2ccccc2n1 Fragment 2: [14*]c1nc2ccccc2[nH]1 ### Response: c1ccc2nc(NCCCc3nc4ccccc4[nH]3)cnc2c1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. C[C@@H](c1ccccn1)N(C)C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. C1(CCCCC1)NC(=O)N1CCC(CC1)N1CCN(C(=O)C1=O)Cc1ccc(cc1)C ### Response: Cc1ccc(CN2CCN(C3CCN(C(=O)NC4CCCCC4)CC3)C(=O)C2=O)cc1
functional_group
### Instruction: Does the molecule contain a ether group? CCOc1nnnn1-c1ccccc1 ### Response: Yes
functional_group
### Instruction: Does the molecule contain a halide group? C[C@@H]([NH2+][C@@H]1CCSc2ccc(F)cc21)c1ccc(-n2ccnn2)cc1 ### Response: Yes
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CCOC(=O)NCCCn1c(C)cc2ccccc21 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC[NH2+]Cc1ccc(CN(C)c2ccccc2F)nc1 ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)C[NH+]([5*])C Fragment 2: [1*]C(=O)C[4*] ### Response: C[NH+](CC(=O)NCC1CCC1)Cc1ccc(C(F)(F)F)cc1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O[C@H](C[NH+](Cc1ccccc1)C1CC1)c1ccc(F)cc1 ### Response: 2
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CSc1nc(-c2ccc(C)cc2)c(C#N)c(=O)[nH]1 ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)CC[8*] Fragment 2: [3*]OCC ### Response: CCOC(=O)CC[C@H]1CCC[NH+](Cc2ccc(C#N)o2)C1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. COc1ccc(OC)c2[nH]c(=O)c(CCNC(=O)c3ccccc3F)cc12 ### Response: 3
functional_group
### Instruction: Does the molecule contain a ester group? COc1ccc2ccc(OC(=O)c3cccnc3N3CCCCC3)cc2c1 ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. O(c1ccc(C2(CCOCC2)C[NH2+]Cc2c[nH]cc2)cc1)CC ### Response: CCOc1ccc(C2(C[NH2+]Cc3cc[nH]c3)CCOCC2)cc1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COc1cccc([C@@H]2[NH2+][C@@](CCSC)(C(=O)[O-])[C@@H]3C(=O)N(C(C)C)C(=O)[C@@H]32)c1O ### Response: 3
canonicalization
### Instruction: Canonicalize the following SMILES string. c1c([C@@H](N(C(=O)Nc2c(cc(F)cc2F)F)C2CC2)C)occ1 ### Response: C[C@@H](c1ccco1)N(C(=O)Nc1c(F)cc(F)cc1F)C1CC1
functional_group
### Instruction: Does the molecule contain a amide group? CCC(=O)N(Cc1ccco1)Cc1cc2ccc(C)cc2[nH]c1=O ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COc1ccc(C2=C[C@@H](C(=O)N/N=C/c3ccc(C)cc3)N=N2)cc1 ### Response: 1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. C[C@H](NC(=O)N[C@@H]1C[C@@H]1c1ccccc1F)[C@@H](O)c1ccc(Cl)cc1 ### Response: 2
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CC1(C)C[NH+]=C(N2CCN(C(=O)c3cccc(-n4cccn4)c3)CC2)S1 ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. C1C(COCC(=O)N([C@H]2CCCC[C@@H]2S(C)(=O)=O)C)C1 ### Response: CN(C(=O)COCC1CC1)[C@H]1CCCC[C@@H]1S(C)(=O)=O
ring_counting
### Instruction: Count the six-membered rings in the following molecule. C[C@@H]1COC[C@@H](C)N1C(=O)CSc1nnnn1C ### Response: 1
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? CC[C@H](NC(=O)N[C@H](C)CCCO)c1cccs1 ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. C1C([C@H]2N(C(=O)NCC3(Cc4ccccc4)CC3)CCOC2)C1 ### Response: O=C(NCC1(Cc2ccccc2)CC1)N1CCOC[C@H]1C1CC1
functional_group
### Instruction: Does the molecule contain a hydroxyl group? COc1cc(F)cc(CNC(=O)Cc2nc(-c3ccsc3)oc2C)c1 ### Response: No
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? COc1ccccc1/N=N\c1c(O)n[nH]c1C ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@H](NC(=O)NCc1ccc([N+](=O)[O-])cc1)[C@@H](C)CO ### Response: 4
ring_counting
### Instruction: Count the five-membered rings in the following molecule. O=C(NCCc1cc(Cl)c2c(c1)OCCO2)C1CCN(C(=O)c2cccs2)CC1 ### Response: 1
functional_group
### Instruction: Does the molecule contain a amine group? C[C@H](NC(=O)N[C@H](C)c1ccncc1)c1ccc(N2CCCC2=O)cc1 ### Response: No
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COc1cccc(N2CC[C@@H](CNC(=O)c3c(C)oc(C)c3C)C2)c1 ### Response: 1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. C[C@H]1[C@@H]([C@H]([NH3+])[C@@H](C)c2ccccn2)[C@@H](C)O[C@H]1C ### Response: 1
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? N#CCC(=O)Nc1ccc(-c2nc3ccccc3o2)cc1 ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. c1cc(C(=O)N2[C@@H]3CCCC[C@@H]3CCC2)ccc1NC(=O)CSc1n(C)nnn1 ### Response: Cn1nnnc1SCC(=O)Nc1ccc(C(=O)N2CCC[C@H]3CCCC[C@H]32)cc1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1c(ccc(C[C@H](N(C(c2ccc(cc2)-c2nnc(o2)C)=O)C)C)c1)Cl ### Response: Cc1nnc(-c2ccc(C(=O)N(C)[C@H](C)Cc3ccc(Cl)cc3)cc2)o1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(NCC(NCCc2ccccc2)=O)ccc(c(c1)C)-n1nnnc1 ### Response: Cc1cc(NCC(=O)NCCc2ccccc2)ccc1-n1cnnn1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [16*]c1ccc(F)cc1 Fragment 2: [5*]N/C=C1\C(=O)NC(=S)N([10*])C1=O ### Response: CCN(CC)c1ccc(N/C=C2\C(=O)NC(=S)N(c3ccc(F)cc3)C2=O)cc1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [3*]Oc1cccc(Cl)c1 Fragment 2: [3*]O[C@@H]1CCN([5*])C1 ### Response: Clc1cccc(O[C@@H]2CCN(Cc3cnc(N4CCOCC4)nc3)C2)c1
canonicalization
### Instruction: Canonicalize the following SMILES string. N(S(c1ccc(CC#N)cc1)(=O)=O)[C@H](C(=O)[O-])C(C)(C)C ### Response: CC(C)(C)[C@H](NS(=O)(=O)c1ccc(CC#N)cc1)C(=O)[O-]
functional_group
### Instruction: Does the molecule contain a aldehyde group? Cc1ccc(C(=O)NCc2cnc(C)s2)c(NN)c1 ### Response: No
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCOc1ccc(C(=O)CN2C(=O)N[C@@]3(CCCC[C@@H]3C)C2=O)cc1 ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. [NH2+]1C[C@H]([C@H](C1)C(N(CC(=O)[O-])CC#C)=O)C ### Response: C#CCN(CC(=O)[O-])C(=O)[C@H]1C[NH2+]C[C@H]1C
ring_counting
### Instruction: Count the five-membered rings in the following molecule. C=C1CCC[C@]2(C)C[C@H]3OC(=O)[C@H](CN(C)CC4OCCO4)[C@H]3C[C@@H]12 ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C(Cc1csc(-c2ccoc2)n1)N[C@H](c1ccccc1)C1CCC1 ### Response: 2