task
stringclasses
5 values
input
stringlengths
89
339
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? NC(=O)[C@H](c1ccccc1)N1CCCN(CC(F)F)CC1 ### Response: 2
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CCOc1ccc(-c2nc3ncccn3c2NCc2ccc(Cl)cc2)cc1OC ### Response: 3
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C(c1ccc(Cn2nnc3ccccc32)cc1)N1CCN(S(=O)(=O)/C=C/c2ccccc2)CC1 ### Response: 2
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CC(C)N(C)C(=O)NCc1ccnc(OC(C)(C)C)c1 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(c(cccc1)NC(C(NCc1ccc(cc1)C)=O)=O)Cl ### Response: Cc1ccc(CNC(=O)C(=O)Nc2ccccc2Cl)cc1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(C(N)=O)cccc(NC([C@@H](C)Oc2cccc(C)c2)=O)c1 ### Response: Cc1cccc(O[C@H](C)C(=O)Nc2cccc(C(N)=O)c2)c1
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? CC[C@H](C)NC(=O)[C@H]1CSCN1C(=O)c1ccc(-c2ccccc2Cl)o1 ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. c1cc(ccc1)-c1nc(on1)NC(=O)N ### Response: NC(=O)Nc1nc(-c2ccccc2)no1
functional_group
### Instruction: Does the molecule contain a halide group? CC[C@H](C[NH3+])[C@](C)(O)c1cc(F)c(Cl)cc1Cl ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(C(N)=O)c(ccc(c1)-c1n(/N=C/c2c(C)ccs2)/c(sc1)=N/CC)O ### Response: CC/N=c1\scc(-c2ccc(O)c(C(N)=O)c2)n1/N=C/c1sccc1C
functional_group
### Instruction: Does the molecule contain a sulfonyl group? Cc1ccc(Cl)cc1/N=C1/S[C@@H](CC(=O)Nc2cc(Cl)ccc2C)C(=O)N1C ### Response: No
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1cc([O-])nc(SCC(=O)N[C@H]2N=C3CCCC[C@@H]3S2)n1 ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [3*]OC[C@@H]1CCCN1[5*] Fragment 2: [5*]N(C)C ### Response: CN(C)c1ncc(CN2CCC[C@H]2COc2ccccc2)s1
functional_group
### Instruction: Does the molecule contain a ketone group? NC(=O)c1cn(CC(=O)NCCc2ccc(Cl)cc2Cl)c2ccccc12 ### Response: No
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [6*]C(C)=O Fragment 2: [5*]N1/C(=N/C([6*])=O)S[C@@H]2CS(=O)(=O)C[C@H]21 ### Response: CC(=O)c1cccc(N2/C(=N/C(=O)C3CCCCC3)S[C@@H]3CS(=O)(=O)C[C@H]32)c1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. C[C@H](NC(=O)c1cccc(SCC#N)c1)C(=O)N1CCCC[C@@H]1C ### Response: 0
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC(C)CC(=O)N1CCN(C(=O)c2ccc(Br)cc2)CC1 ### Response: 4
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(cccc([C@@H]2[C@@H](NC(=O)c3[nH]nc(C)c3)C2)c1)Cl ### Response: Cc1cc(C(=O)N[C@H]2C[C@@H]2c2cccc(Cl)c2)[nH]n1
functional_group
### Instruction: Does the molecule contain a amide group? CCCN(CC)C(=O)N(CC(=O)[O-])C(C)(C)C ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]NCCC[8*] Fragment 2: [9*]n1ccc2ccccc21 ### Response: O=C(NCCCn1ccc2ccccc21)c1scnc1C1CC1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. O=C(NCCOc1ccc(-c2ccc(F)cc2)nn1)Nc1ccc(Cl)cc1 ### Response: 0
ring_counting
### Instruction: Count the five-membered rings in the following molecule. C#CCNC(=O)[C@@]1(Cc2ccccc2-c2cccnc2)CC[NH+](Cc2ccccc2Cl)C1 ### Response: 1
functional_group
### Instruction: Does the molecule contain a amide group? CC(C)(C)Oc1ccc(C(=O)Nc2ccc(NC(=O)NC3CC3)cc2)cc1 ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(-c2cccc([N+]([O-])=O)c2)nn(CC(Nc2cccc3nsnc32)=O)cn1 ### Response: O=C(Cn1cnc(-c2cccc([N+](=O)[O-])c2)n1)Nc1cccc2nsnc12
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)C[8*] Fragment 2: [5*]NCC(C)C ### Response: C=C1c2ccccc2C(=O)N1CC(=O)Oc1ccc(C)cc1C(=O)NCC(C)C
ring_counting
### Instruction: Count the six-membered rings in the following molecule. COc1ccc(NC(=O)[C@H](C)SCc2nc3sc(C)c(C)c3c(=O)[nH]2)cc1 ### Response: 2
functional_group
### Instruction: Does the molecule contain a halide group? O=C(NCCC1CCN(c2cc[nH+]cc2)CC1)C(=O)Nc1cccc(F)c1 ### Response: Yes
functional_group
### Instruction: Does the molecule contain a nitrile group? CC[C@H](CNC(=O)c1ccccc1Cl)c1ccccc1 ### Response: No
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)c1ccnc(Cl)c1 Fragment 2: [5*]Nc1c(C)cccc1CC ### Response: CCc1cccc(C)c1NC(=O)COC(=O)c1ccnc(Cl)c1
functional_group
### Instruction: Does the molecule contain a phenol group? COC(=O)c1coc(CN2Cc3ccccc3C[C@H]2C(=O)NC(C)(C)C)n1 ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. c1ccc(/C=C/S(=O)(=O)NCCC(N(C)C)=O)cc1 ### Response: CN(C)C(=O)CCNS(=O)(=O)/C=C/c1ccccc1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1cc(ccc1C)/C=C1/C(=NOC1=O)c1ccc(Br)cc1 ### Response: Cc1ccc(/C=C2\C(=O)ON=C2c2ccc(Br)cc2)cc1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. COc1ccccc1-c1nn([C@@H](Nc2ccccc2)c2ccccc2)c(=S)o1 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. COc1cccc(CN2C(CC3(CC[NH+](Cc4cocc4)CC3)C2)=O)c1 ### Response: COc1cccc(CN2CC3(CC[NH+](Cc4ccoc4)CC3)CC2=O)c1
canonicalization
### Instruction: Canonicalize the following SMILES string. [C@@H]1(N(CCC1)C([C@H]1CC(=O)N(C1)CC)=O)c1nc2c([nH]1)cccc2 ### Response: CCN1C[C@@H](C(=O)N2CCC[C@H]2c2nc3ccccc3[nH]2)CC1=O
functional_group
### Instruction: Does the molecule contain a nitrile group? CCC[NH+](C)CCCN1CCOCC1 ### Response: No
ring_counting
### Instruction: Count the five-membered rings in the following molecule. O=C(CSCc1cccnc1)N[C@@H]1CCc2c(O)cccc21 ### Response: 1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. COc1cc(F)cc(CNC(=O)N2C[C@H]3CC=CC[C@H]3C2)c1 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. [C@H]1(CCO[C@H]1c1ccccc1)CNc1ncnc(-n2cncc2)c1 ### Response: c1ccc([C@@H]2OCC[C@H]2CNc2cc(-n3ccnc3)ncn2)cc1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1c(C)ccc(C(Oc2ccc(/C=C3/C(=N)N4N=C(SC4=NC3=O)N3CCCC3)cc2)=O)c1 ### Response: Cc1ccc(C(=O)Oc2ccc(/C=C3/C(=N)N4N=C(N5CCCC5)SC4=NC3=O)cc2)cc1
canonicalization
### Instruction: Canonicalize the following SMILES string. [NH+]1(CCC(C)CC1)CCNC(=O)C(=O)Nc1c(n(ccc1C)C)=O ### Response: Cc1ccn(C)c(=O)c1NC(=O)C(=O)NCC[NH+]1CCC(C)CC1
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? CCc1nc2ccccc2n1C1CCN(c2ccnc(Cl)c2)CC1 ### Response: Yes
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? CC[C@]1(C)C[NH2+][C@@H](C(C)(C)C)CN1Cc1cccc(O)c1 ### Response: Yes
functional_group
### Instruction: Does the molecule contain a amine group? CN(C(=O)c1cnn(-c2ccccc2)c1)c1ccc(Br)cn1 ### Response: No
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[NH+](C)CC[C@H](Nc1cc(C2CC2)ncn1)c1ccccc1 ### Response: 3
ring_counting
### Instruction: Count the six-membered rings in the following molecule. O=C(N/N=C\c1ccc(F)cc1)C1=CC=CC2=CC=N[C@H]21 ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CSc1ccccc1NCC(=O)N(C)Cc1ccc(F)cc1 ### Response: 2
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CC(C)[C@@H]1C(=O)NCC[NH+]1Cc1cc(F)cc(F)c1 ### Response: 2
functional_group
### Instruction: Does the molecule contain a ether group? COc1ccc(N)c(SC[C@@H]2CC[C@H](C(=O)NN)O2)c1 ### Response: Yes
ring_counting
### Instruction: Count the six-membered rings in the following molecule. O=C(NC(CO)CO)N[C@@H]1CCC[C@@H](C(F)(F)F)C1 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC(=O)N1N=C(N)S[C@@]1(C)c1ccccc1 ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]NC(N[5*])=[NH+]C Fragment 2: [15*][C@H]1C[C@H]1C ### Response: C/[NH+]=C(\NCC(C)(C)c1ccc(OC)cc1)N[C@H]1C[C@H]1C
canonicalization
### Instruction: Canonicalize the following SMILES string. c1c(Cl)c(Br)cc(NC(C2CC[NH2+]CC2)=O)c1 ### Response: O=C(Nc1ccc(Cl)c(Br)c1)C1CC[NH2+]CC1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(ccc(C)cc1)S(N/N=C\c1cc(Br)c(o1)C)(=O)=O ### Response: Cc1ccc(S(=O)(=O)N/N=C\c2cc(Br)c(C)o2)cc1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [9*]n1nc2c(cc1=O)CCCC2 Fragment 2: [1*]C(=O)C[8*] ### Response: O=C(Cn1nc2c(cc1=O)CCCC2)N1CC[C@]2(O)CCCC[C@@H]2C1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@H](c1ccccc1)[C@@H](C)NS(=O)(=O)c1cn(C)c(=O)n(C)c1=O ### Response: 4
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [14*]c1cccs1 Fragment 2: [4*]Cc1nc([14*])n[nH]1 ### Response: C[C@@H]1CSC(SCc2nc(-c3cccs3)n[nH]2)=N1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CN(c1ncncc1N)[C@H]1CCSC1 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C(Cn1cccn1)N1CC(c2nc3ccccc3[nH]2)C1 ### Response: 2
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Cc1cc(SCc2nc(N)nc(N)n2)nc2c(C)cccc12 ### Response: 3
canonicalization
### Instruction: Canonicalize the following SMILES string. c1cc(cc([C@@H]2C(=C(Nc3n2nnn3)CC)C(=O)OC)c1OC)OC ### Response: CCC1=C(C(=O)OC)[C@@H](c2cc(OC)ccc2OC)n2nnnc2N1
canonicalization
### Instruction: Canonicalize the following SMILES string. C1(CC[NH+](Cc2cn(nc2C(C)(C)C)-c2ccccc2)CC1)c1n[nH]cn1 ### Response: CC(C)(C)c1nn(-c2ccccc2)cc1C[NH+]1CCC(c2nc[nH]n2)CC1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]Cc1ccccc1C Fragment 2: [5*]Nc1ccccc1Cl ### Response: Cc1ccccc1C[NH+](C)CC(=O)N(C)CC(=O)Nc1ccccc1Cl
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(C)=O Fragment 2: [4*][C@@H](C)c1nc(C)cs1 ### Response: CC(=O)NCCc1ccc([C@@H](C)[NH2+][C@@H](C)c2nc(C)cs2)cc1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. C[C@@H](N[C@@H]1CCO[C@@H]1c1ccc(Cl)c(F)c1)c1ccncc1 ### Response: 2
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? CCc1ncc(CN2CCC(C(=O)Nc3ccc(F)c(Cl)c3)CC2)s1 ### Response: Yes
functional_group
### Instruction: Does the molecule contain a phenol group? CS(=O)(=O)[C@H]1CCC[C@@H]([C@@H]2CCCCCC2=O)C1 ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. c12c(C[C@H]([NH+](C)C(C)(CC)C)[C@H]1NC)ccc(c2)OC ### Response: CCC(C)(C)[NH+](C)[C@H]1Cc2ccc(OC)cc2[C@@H]1NC
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1[nH+]cn(C[C@H](C)[C@H]2CC[NH+]3CCC[C@H]23)c1C ### Response: 3
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(sc(nc1)CN[C@H]1CC[C@@H](C1)[NH+](C)C)-c1ccccc1 ### Response: C[NH+](C)[C@H]1CC[C@H](NCc2ncc(-c3ccccc3)s2)C1
canonicalization
### Instruction: Canonicalize the following SMILES string. Fc1c(c(c(c(F)c1F)F)F)CS[C@@H](C)C(=O)[O-] ### Response: C[C@H](SCc1c(F)c(F)c(F)c(F)c1F)C(=O)[O-]
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1cccc(C(=O)Nc2cccc(OCC(=O)N3CCCC3)c2)c1 ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]Cc1c(C)nn(CC)c1C Fragment 2: [5*][NH+]1C[C@@H](C)CC[C@@H]1C ### Response: CCn1nc(C)c(C[NH+]2C[C@@H](C)CC[C@@H]2C)c1C
canonicalization
### Instruction: Canonicalize the following SMILES string. O(C(c1nc(on1)CCNS(c1ccccc1)(=O)=O)(C)C)C ### Response: COC(C)(C)c1noc(CCNS(=O)(=O)c2ccccc2)n1
functional_group
### Instruction: Does the molecule contain a amide group? CN(Cc1ccsc1)C(=O)c1cccnc1Cl ### Response: Yes
functional_group
### Instruction: Does the molecule contain a nitro group? Cc1cccc(OC(=O)c2ccc(Cl)c(S(C)(=O)=O)c2)c1 ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. C(N1CCC[C@@H]2CCC[C@@H]21)(=O)N[C@H](C)c1ncc(s1)C ### Response: Cc1cnc([C@@H](C)NC(=O)N2CCC[C@@H]3CCC[C@@H]32)s1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]NCCC[8*] Fragment 2: [1*]C(=O)c1cn([9*])nn1 ### Response: Cc1n[nH]c(C)c1CCCNC(=O)c1cn(C2CCC([NH3+])CC2)nn1
canonicalization
### Instruction: Canonicalize the following SMILES string. CCC(c1ccc(OC[C@H](O)C[NH+]2C[C@@H](O)[C@H](CC2)C)cc1)=O ### Response: CCC(=O)c1ccc(OC[C@H](O)C[NH+]2CC[C@H](C)[C@H](O)C2)cc1
functional_group
### Instruction: Does the molecule contain a amide group? C[C@H](NC(=O)CSc1nnc2c3cc(Br)ccc3n(C)c2n1)c1ccccc1 ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CN(C)C(=O)Cc1nc(CSc2ccncc2N)cs1 ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)CC[4*] Fragment 2: [5*]N1CCCC[C@H]1CC ### Response: CC[C@@H]1CCCCN1C(=O)CCNS(=O)(=O)c1ccc(C)cc1C
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [14*]c1nccn1S(=O)(=O)c1cc([16*])ccc1OC Fragment 2: [8*]C(C)C ### Response: COc1ccc(C(C)C)cc1S(=O)(=O)n1ccnc1C(C)C
ring_counting
### Instruction: Count the six-membered rings in the following molecule. COc1ccc(/C=C/C(=O)c2ccc(C)cc2)cc1O ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [13*][C@H]1OCCC[C@H]1[15*] Fragment 2: [6*]C(=O)[O-] ### Response: CC[C@H](C)[C@H]1OCCC[C@H]1C(=O)[O-]
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N(C)c1ccc2nc(C)sc2c1 Fragment 2: [1*]C(=O)[C@@H](C)N[5*] ### Response: Cc1nc2ccc(N(C)C(=O)[C@@H](C)NC(=O)C(C)(C)C)cc2s1
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? CCc1cc2ccccc2c(=O)n1CC(=O)[O-] ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. C1C[C@@H](C(=O)[O-])[C@@H](c2c(cccc2)C)N(C1=O)CCOC ### Response: COCCN1C(=O)CC[C@@H](C(=O)[O-])[C@H]1c1ccccc1C
ring_counting
### Instruction: Count the five-membered rings in the following molecule. O=C(CCn1cnc2sccc2c1=O)NCc1ccc(OC(F)F)cc1 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(OC)ccccc1[C@@H](C)CC(=O)Oc1ccc2nccnc2c1 ### Response: COc1ccccc1[C@@H](C)CC(=O)Oc1ccc2nccnc2c1
canonicalization
### Instruction: Canonicalize the following SMILES string. C1COc2c(cc(cc2O1)C(=O)O[C@H](C(NC1CCCCC1)=O)C)OC ### Response: COc1cc(C(=O)O[C@@H](C)C(=O)NC2CCCCC2)cc2c1OCCO2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COC(=O)[C@H]1CCCCC[C@@H]1NC(=O)Cn1nc2ccccn2c1=O ### Response: 2
functional_group
### Instruction: Does the molecule contain a carboxyl group? Cc1nn(C)c(C)c1CC(=O)O[C@H](C)c1ccc(Cl)s1 ### Response: No
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C(CSC1=NC(=O)[C@H](/C=C/c2ccccc2)N=N1)Nc1ccc(Cl)cc1 ### Response: 2
functional_group
### Instruction: Does the molecule contain a amide group? COc1ccc(CN2C(=O)NC(=O)/C(=C\c3cnc(-c4ccccc4)nc3)C2=O)cc1 ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. c12nc(Nc3ccccc3)c(C(=O)OC(C)C)nc2cccc1 ### Response: CC(C)OC(=O)c1nc2ccccc2nc1Nc1ccccc1
canonicalization
### Instruction: Canonicalize the following SMILES string. C(c1cccc(c1)C)(=O)NNC(=O)[C@H]1CC(=C(C[C@@H]1C(=O)[O-])C)C ### Response: CC1=C(C)C[C@H](C(=O)NNC(=O)c2cccc(C)c2)[C@@H](C(=O)[O-])C1
functional_group
### Instruction: Does the molecule contain a ether group? CCOCCn1/c(=N/C(=O)[C@H]2COc3ccccc3O2)sc2cc(OC)ccc21 ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]Nc1cc(Cl)ccc1F Fragment 2: [1*]C(=O)C([1*])=O ### Response: CC1CCN(C(=O)C(=O)Nc2cc(Cl)ccc2F)CC1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCS(=O)(=O)N1C[C@H](C(=O)N[C@@H](C)CCc2ccccc2)Oc2ccccc21 ### Response: 4