task stringclasses 5
values | input stringlengths 89 339 |
|---|---|
ring_counting | ### Instruction:
Count the five-membered rings in the following molecule.
Cc1ccc2nc(SCC(=O)N[C@@H]3CCC[C@H](C)[C@@H]3C)[nH]c2c1
### Response:
1 |
functional_group | ### Instruction:
Does the molecule contain a halide group?
CC(C)(C)c1ccc(C(=O)Nc2c3c(nn2-c2cccc(Cl)c2)CS(=O)(=O)C3)cc1
### Response:
Yes |
fragment_assembly | ### Instruction:
Assemble these two molecular fragments into a single molecule.
Fragment 1: [11*]Sc1cc(C)nc2ccc(I)cc12
Fragment 2: [4*]CC(=O)[O-]
### Response:
Cc1cc(SCC(=O)[O-])c2cc(I)ccc2n1 |
chain_length | ### Instruction:
What is the length of the longest acyclic carbon chain in the molecule?
COc1ccc(CN2CCC(N3CCO[C@H](C)C3)CC2)c(OC)c1
### Response:
1 |
chain_length | ### Instruction:
What is the length of the longest acyclic carbon chain in the molecule?
O=C([O-])CC1(CC(=O)Nc2ccc(F)cc2F)CCCCC1
### Response:
2 |
ring_counting | ### Instruction:
Count the six-membered rings in the following molecule.
[N-]=[N+]=NC[C@H]1C[NH+]=C(N)N1c1cccc(F)c1
### Response:
1 |
canonicalization | ### Instruction:
Canonicalize the following SMILES string.
c1(NC(C(NCCC[NH+]2C[C@H](C)CCC2)=O)=O)cnc(cc1)OC
### Response:
COc1ccc(NC(=O)C(=O)NCCC[NH+]2CCC[C@@H](C)C2)cn1 |
fragment_assembly | ### Instruction:
Assemble these two molecular fragments into a single molecule.
Fragment 1: [4*]CC1CCCCC1
Fragment 2: [5*]N1CC[NH+]([5*])CC1
### Response:
CON(C)C(=O)CN1CC[NH+](CC2CCCCC2)CC1 |
functional_group | ### Instruction:
Does the molecule contain a nitro group?
C[C@@H](Sc1nnc(C2CCCCC2)n1N)C(=O)Nc1nc(-c2cccc([N+](=O)[O-])c2)cs1
### Response:
Yes |
ring_counting | ### Instruction:
Count the five-membered rings in the following molecule.
N#C[C@]1(NC2CC2)CC[C@@H](Sc2n[nH]c(=O)n2C2CC2)C1
### Response:
2 |
chain_length | ### Instruction:
What is the length of the longest acyclic carbon chain in the molecule?
C[C@@H]1CCC/C(=C/c2ccc3c(c2)OCO3)C1=O
### Response:
1 |
functional_group | ### Instruction:
Does the molecule contain a amide group?
C[C@@H]1CCC[C@@H](C)C1NC(=O)NCCc1cn2ccccc2n1
### Response:
Yes |
ring_counting | ### Instruction:
Count the six-membered rings in the following molecule.
CN[C@]1(C(=O)[O-])CC[C@@H]([NH+](C)C[C@@H]2CCCCO2)C1
### Response:
1 |
ring_counting | ### Instruction:
Count the five-membered rings in the following molecule.
COc1ccc([C@@H](C)[NH+](C)CCC(=O)Nc2ccccc2Cl)cc1
### Response:
0 |
chain_length | ### Instruction:
What is the length of the longest acyclic carbon chain in the molecule?
Cc1ccc(C(=O)Nc2nccs2)cc1[N+](=O)[O-]
### Response:
1 |
fragment_assembly | ### Instruction:
Assemble these two molecular fragments into a single molecule.
Fragment 1: [5*]NCC(F)(F)F
Fragment 2: [1*]C(=O)N1CCN([5*])CC1
### Response:
O=C(NCC(F)(F)F)N1CCN(C(=O)c2cccnc2)CC1 |
canonicalization | ### Instruction:
Canonicalize the following SMILES string.
n1c(sc(c1)Cc1cc(ccc1)C)NC(=O)CN1C(=S)S[C@H](CC)C1=O
### Response:
CC[C@H]1SC(=S)N(CC(=O)Nc2ncc(Cc3cccc(C)c3)s2)C1=O |
canonicalization | ### Instruction:
Canonicalize the following SMILES string.
C1(C(Nc2cc(-c3sc4ccccc4n3)ccc2)=O)CCOCC1
### Response:
O=C(Nc1cccc(-c2nc3ccccc3s2)c1)C1CCOCC1 |
canonicalization | ### Instruction:
Canonicalize the following SMILES string.
c1cc(cc(-c2cn3c(scc3)n2)c1)NC(CSc1ccc(cc1)F)=O
### Response:
O=C(CSc1ccc(F)cc1)Nc1cccc(-c2cn3ccsc3n2)c1 |
canonicalization | ### Instruction:
Canonicalize the following SMILES string.
c1cc[n+](cc1C(N[C@@H](c1c(cccc1)C(F)(F)F)C)=O)[O-]
### Response:
C[C@@H](NC(=O)c1ccc[n+]([O-])c1)c1ccccc1C(F)(F)F |
canonicalization | ### Instruction:
Canonicalize the following SMILES string.
C12CC3CC(CC(C3)C1)(C2)C(Nc1nccc(c1)C)=O
### Response:
Cc1ccnc(NC(=O)C23CC4CC(CC(C4)C2)C3)c1 |
ring_counting | ### Instruction:
Count the five-membered rings in the following molecule.
CC(C)C1CCC([NH+](C)CCn2cnnc2)CC1
### Response:
1 |
canonicalization | ### Instruction:
Canonicalize the following SMILES string.
c1c(cc(Cl)cc1)-c1sc(c(n1)C)C(=O)N[C@@H]1C[C@H]([NH+](C)C)CC1
### Response:
Cc1nc(-c2cccc(Cl)c2)sc1C(=O)N[C@H]1CC[C@@H]([NH+](C)C)C1 |
chain_length | ### Instruction:
What is the length of the longest acyclic carbon chain in the molecule?
Cc1nc(Nc2ccccc2F)c2c3c(sc2n1)CCC3
### Response:
1 |
functional_group | ### Instruction:
Does the molecule contain a nitro group?
CCCOc1cc(C[NH+]2CCC[C@H]2c2cnn(C)c2C)ccc1OC
### Response:
No |
canonicalization | ### Instruction:
Canonicalize the following SMILES string.
c1cc2/C(=N/NC(c3cccc(c3)Cl)=O)CCCc2cc1
### Response:
O=C(N/N=C1\CCCc2ccccc21)c1cccc(Cl)c1 |
canonicalization | ### Instruction:
Canonicalize the following SMILES string.
c1cc(C(F)(F)F)c(F)c(C(=O)Nc2ccc(COCC)cc2)c1
### Response:
CCOCc1ccc(NC(=O)c2cccc(C(F)(F)F)c2F)cc1 |
ring_counting | ### Instruction:
Count the five-membered rings in the following molecule.
COc1ccc(N2C(=O)C[C@@H](N(CCc3ccccc3)C(=O)c3ccc(F)cc3)C2=O)cc1
### Response:
1 |
functional_group | ### Instruction:
Does the molecule contain a hydroxyl group?
CCNC(=O)N1CCc2ccc(NC(=O)N(C)[C@@H]3CCC[C@H](C)C3)cc21
### Response:
No |
canonicalization | ### Instruction:
Canonicalize the following SMILES string.
c1(C(N2CCC(C(=O)NC)CC2)=O)ncccc1
### Response:
CNC(=O)C1CCN(C(=O)c2ccccn2)CC1 |
functional_group | ### Instruction:
Does the molecule contain a phenol group?
O=C1[C@@H](NC(=O)N2CCOC[C@H]2C2CC2)CCN1c1cccc(Cl)c1
### Response:
No |
functional_group | ### Instruction:
Does the molecule contain a ketone group?
COc1ccc(C(=O)[C@@H]2CCCN(Cc3cnc(N(C)C)s3)C2)cc1OC
### Response:
Yes |
ring_counting | ### Instruction:
Count the five-membered rings in the following molecule.
CSc1ccccc1C(=O)NCc1cc[nH]n1
### Response:
1 |
canonicalization | ### Instruction:
Canonicalize the following SMILES string.
c1cc(C(F)(F)F)cc(c1)C1(O)CCN(C(=S)NCC)CC1
### Response:
CCNC(=S)N1CCC(O)(c2cccc(C(F)(F)F)c2)CC1 |
fragment_assembly | ### Instruction:
Assemble these two molecular fragments into a single molecule.
Fragment 1: [4*][C@H]([8*])C[NH3+]
Fragment 2: [16*]c1cc(Br)c2c(c1)OCO2
### Response:
CC1(C)CCN([C@@H](C[NH3+])c2cc(Br)c3c(c2)OCO3)C1 |
canonicalization | ### Instruction:
Canonicalize the following SMILES string.
N#Cc1cc(NC([C@@H](C)O/N=C(\c2sccc2)N)=O)ccc1
### Response:
C[C@@H](O/N=C(/N)c1cccs1)C(=O)Nc1cccc(C#N)c1 |
chain_length | ### Instruction:
What is the length of the longest acyclic carbon chain in the molecule?
CCOC(=O)c1noc2ncn([C@@H](C)C(=O)N(C)c3cccc(C)c3)c(=O)c12
### Response:
3 |
functional_group | ### Instruction:
Does the molecule contain a thiol group?
CCC(=O)c1ccc(F)c(F)c1
### Response:
No |
functional_group | ### Instruction:
Does the molecule contain a aromatic_ring group?
CCCNC(=O)CN1CCN(C(=O)Cc2c(C)nn(-c3ccccc3)c2C)CC1
### Response:
Yes |
ring_counting | ### Instruction:
Count the five-membered rings in the following molecule.
Cc1nc([N+](=O)[O-])cn1CC(=O)NC[C@@H]1CN2CCCC[C@@H]2CO1
### Response:
1 |
fragment_assembly | ### Instruction:
Assemble these two molecular fragments into a single molecule.
Fragment 1: [16*]c1ccc(F)cc1
Fragment 2: [1*]C(=O)c1cscn1
### Response:
COC(=O)[C@H]1CN(C(=O)c2cscn2)C[C@@H]1c1ccc(F)cc1 |
functional_group | ### Instruction:
Does the molecule contain a thiol group?
C[C@@H](CS(C)(=O)=O)N(Cc1c[nH]nc1-c1ccc(F)cc1)C1CC1
### Response:
No |
chain_length | ### Instruction:
What is the length of the longest acyclic carbon chain in the molecule?
CCSCc1ccnc(NCc2cnc3c(C)cccn23)c1
### Response:
2 |
fragment_assembly | ### Instruction:
Assemble these two molecular fragments into a single molecule.
Fragment 1: [4*]Cc1ccc(OC)cc1
Fragment 2: [4*]CCO
### Response:
COc1ccc(C[NH+]2CCN(CCO)CC2)cc1 |
ring_counting | ### Instruction:
Count the five-membered rings in the following molecule.
COCC[NH2+]Cc1c[nH]nc1C1CCCC1
### Response:
2 |
ring_counting | ### Instruction:
Count the five-membered rings in the following molecule.
Cc1nn(C)c2c1nc([C@H](C)Cl)n2[C@@H](C[NH+](C)C)C(C)C
### Response:
2 |
ring_counting | ### Instruction:
Count the six-membered rings in the following molecule.
O=C(C[C@@H](C(=O)[O-])[NH+]1CCN(c2cccc(Cl)c2)CC1)c1ccc(F)cc1
### Response:
3 |
canonicalization | ### Instruction:
Canonicalize the following SMILES string.
c1ccsc1-c1ncc(cn1)CCl
### Response:
ClCc1cnc(-c2cccs2)nc1 |
functional_group | ### Instruction:
Does the molecule contain a amide group?
CC[C@H](C)C[C@H](C)NC(=O)[C@@H]1CCC[NH2+][C@@H]1C
### Response:
Yes |
chain_length | ### Instruction:
What is the length of the longest acyclic carbon chain in the molecule?
Cc1cccc([C@@H](O)[C@@]2(C#N)CCOC2)c1
### Response:
1 |
ring_counting | ### Instruction:
Count the five-membered rings in the following molecule.
[NH3+][C@@H](Cc1cccc(F)c1F)[C@H]1CN2CCC[C@@H]2CO1
### Response:
1 |
chain_length | ### Instruction:
What is the length of the longest acyclic carbon chain in the molecule?
CC1CCN(C(=O)Nc2ccc(C(=O)NC3CCCC3)cc2)CC1
### Response:
1 |
functional_group | ### Instruction:
Does the molecule contain a hydroxyl group?
O=C1N(Cc2cccc(F)c2)c2ccccc2S(=O)(=O)N1c1ccc(F)cc1
### Response:
No |
functional_group | ### Instruction:
Does the molecule contain a amide group?
CC[C@@H](NC(=O)Nc1cc(C)ccc1F)c1nc(C(F)(F)F)cs1
### Response:
Yes |
fragment_assembly | ### Instruction:
Assemble these two molecular fragments into a single molecule.
Fragment 1: [15*]C1CCCCCC1
Fragment 2: [1*]C(=O)[C@H]1CCC(=O)N([10*])C1
### Response:
O=C(NCCc1ccc(Cl)cc1)[C@H]1CCC(=O)N(C2CCCCCC2)C1 |
fragment_assembly | ### Instruction:
Assemble these two molecular fragments into a single molecule.
Fragment 1: [16*]c1ccc(F)cc1
Fragment 2: [1*]C(=O)c1cc2cccc(OC)c2oc1=O
### Response:
COc1cccc2cc(C(=O)OCc3cc(-c4ccc(F)cc4)on3)c(=O)oc12 |
functional_group | ### Instruction:
Does the molecule contain a halide group?
CC(C)[C@@H](CC(=O)OC(C)(C)C)C(=O)[O-]
### Response:
No |
ring_counting | ### Instruction:
Count the six-membered rings in the following molecule.
CCc1ccc(NC(=O)C[C@@H]2C(=O)N(Cc3ccco3)c3nc4ccccc4n32)cc1
### Response:
2 |
canonicalization | ### Instruction:
Canonicalize the following SMILES string.
[S@@](CCC(=O)Nc1ccccc1)(=O)Cc1c(Cl)cc(cc1)OC
### Response:
COc1ccc(C[S@](=O)CCC(=O)Nc2ccccc2)c(Cl)c1 |
functional_group | ### Instruction:
Does the molecule contain a hydroxyl group?
CCC(=O)Nc1ccc(Cl)c(NC(=O)/C=C/c2ccc(C(=O)NC)cc2)c1
### Response:
No |
fragment_assembly | ### Instruction:
Assemble these two molecular fragments into a single molecule.
Fragment 1: [4*]Cc1ccccc1
Fragment 2: [11*]Sc1nncn1/N=C/c1ccccc1[16*]
### Response:
O=C([O-])c1ccccc1/C=N/n1cnnc1SCc1ccccc1 |
fragment_assembly | ### Instruction:
Assemble these two molecular fragments into a single molecule.
Fragment 1: [1*]C(=O)c1oc2c(c1C)C(=O)CC(C)(C)C2
Fragment 2: [5*]N1CCC[C@H](OC)C1
### Response:
CO[C@H]1CCCN(C(=O)c2oc3c(c2C)C(=O)CC(C)(C)C3)C1 |
chain_length | ### Instruction:
What is the length of the longest acyclic carbon chain in the molecule?
O=C(Cc1ccccc1CNC(=O)c1cc2c(ccc3ncccc32)s1)NC1CCCC1
### Response:
2 |
ring_counting | ### Instruction:
Count the five-membered rings in the following molecule.
Fc1cccc(F)c1CNc1ccc(Cl)c(Br)c1
### Response:
0 |
ring_counting | ### Instruction:
Count the six-membered rings in the following molecule.
CCCNC(=O)c1ccc(C)c(N(C)S(C)(=O)=O)c1
### Response:
1 |
functional_group | ### Instruction:
Does the molecule contain a ester group?
CCOc1ccc(C2(C[NH2+]Cc3cc[nH]c3)CCOCC2)cc1
### Response:
No |
ring_counting | ### Instruction:
Count the five-membered rings in the following molecule.
CCC[C@@H](Cl)[C@@H](C)c1ccncc1
### Response:
0 |
fragment_assembly | ### Instruction:
Assemble these two molecular fragments into a single molecule.
Fragment 1: [8*]CCCC
Fragment 2: [4*]Cc1nc2c(c(=O)[nH]c(=O)n2[9*])n1CC
### Response:
CCCCn1c(=O)[nH]c(=O)c2c1nc(C[NH+]1CCC(OC)CC1)n2CC |
functional_group | ### Instruction:
Does the molecule contain a nitro group?
CCN(c1cc(C(N)=S)ccn1)C(C)C
### Response:
No |
functional_group | ### Instruction:
Does the molecule contain a ether group?
CC(=O)CC(=O)N[C@H](C)CCCO
### Response:
No |
canonicalization | ### Instruction:
Canonicalize the following SMILES string.
n1(c2c(cccc2)nc1)NC([C@@H]1CCCN1S(c1ccc(F)cc1)(=O)=O)=O
### Response:
O=C(Nn1cnc2ccccc21)[C@@H]1CCCN1S(=O)(=O)c1ccc(F)cc1 |
functional_group | ### Instruction:
Does the molecule contain a amide group?
C[C@@H]1CCC[C@H](C)[NH+]1CC(=O)Nc1ccccc1SC[C@@H](C)C#N
### Response:
Yes |
ring_counting | ### Instruction:
Count the five-membered rings in the following molecule.
CC1CCN(C(=O)/C=C/c2nc3ccccc3o2)CC1
### Response:
1 |
fragment_assembly | ### Instruction:
Assemble these two molecular fragments into a single molecule.
Fragment 1: [5*]N[C@H]1CCCC[C@@H]1[S@](=O)CC
Fragment 2: [15*][C@H]1CCCC[C@@H]1[S@](=O)CC
### Response:
CC[S@@](=O)[C@H]1CCCC[C@@H]1NC(=O)N1CC[NH+](CC(C)C)CC1 |
fragment_assembly | ### Instruction:
Assemble these two molecular fragments into a single molecule.
Fragment 1: [5*]Nc1ccc(Cl)cc1C([6*])=O
Fragment 2: [16*]c1ccccc1
### Response:
O=C(c1ccccc1)c1cc(Cl)ccc1NCC(=O)N1CCN(c2ccccc2)CC1 |
functional_group | ### Instruction:
Does the molecule contain a aldehyde group?
Cc1ccc2nc(C)c(C)c(C(=O)NCC[NH+]3CCC(CO)CC3)c2c1
### Response:
No |
ring_counting | ### Instruction:
Count the six-membered rings in the following molecule.
C[C@@H](CC(=O)Nc1cccc(F)c1)[NH2+]C[C@H](O)c1c(F)cccc1F
### Response:
2 |
chain_length | ### Instruction:
What is the length of the longest acyclic carbon chain in the molecule?
Nc1nc(-c2ccncc2)cs1
### Response:
0 |
fragment_assembly | ### Instruction:
Assemble these two molecular fragments into a single molecule.
Fragment 1: [6*]C(C)=O
Fragment 2: [16*]c1ccc2nc(N)sc2c1
### Response:
CC(=O)c1ccc2nc(N)sc2c1 |
functional_group | ### Instruction:
Does the molecule contain a aldehyde group?
CCOC(=O)c1cnc2cc(C(=O)OC)ccc2c1N
### Response:
No |
functional_group | ### Instruction:
Does the molecule contain a nitro group?
COCc1c(C(=O)NC(C)C)nnn1-c1ccc(C)cc1
### Response:
No |
canonicalization | ### Instruction:
Canonicalize the following SMILES string.
N(C(=O)CC[NH+]1CC[C@@H]([C@H](C1)O)C)c1ccc(OCc2ccccc2)cc1
### Response:
C[C@H]1CC[NH+](CCC(=O)Nc2ccc(OCc3ccccc3)cc2)C[C@@H]1O |
chain_length | ### Instruction:
What is the length of the longest acyclic carbon chain in the molecule?
O=C(Nc1ccc(F)cc1OCC(F)F)c1n[nH]cc1[N+](=O)[O-]
### Response:
2 |
functional_group | ### Instruction:
Does the molecule contain a amide group?
CCNc1nc2c(s1)[C@H](c1cc(OC)c3c(c1)OCO3)CC(=O)N2
### Response:
Yes |
canonicalization | ### Instruction:
Canonicalize the following SMILES string.
C1N(CCN(C1)[C@H]1CCS(=O)(C1)=O)C(Cc1cccc(c1)OC)=O
### Response:
COc1cccc(CC(=O)N2CCN([C@H]3CCS(=O)(=O)C3)CC2)c1 |
fragment_assembly | ### Instruction:
Assemble these two molecular fragments into a single molecule.
Fragment 1: [10*]N1C(=O)CNC1=O
Fragment 2: [4*]CCC[8*]
### Response:
C[C@@H]1CCN(CCCN2C(=O)CNC2=O)c2ccccc21 |
fragment_assembly | ### Instruction:
Assemble these two molecular fragments into a single molecule.
Fragment 1: [15*][C@@H]1CC[NH2+]C[C@H]1C
Fragment 2: [5*]N1CCCC1
### Response:
C[C@@H]1C[NH2+]CC[C@H]1N1CCCC1 |
canonicalization | ### Instruction:
Canonicalize the following SMILES string.
n1(C2CCCC2)c2nc3c4c(cc(O)cc4)oc3c(c2c(n1)O)-c1cc2c(cccc2)[nH]c1=O
### Response:
O=c1[nH]c2ccccc2cc1-c1c2oc3cc(O)ccc3c2nc2c1c(O)nn2C1CCCC1 |
canonicalization | ### Instruction:
Canonicalize the following SMILES string.
c1cnc(Oc2ccc(cc2)NC(N2CCCC[C@@H]2CO)=O)nc1
### Response:
O=C(Nc1ccc(Oc2ncccn2)cc1)N1CCCC[C@@H]1CO |
ring_counting | ### Instruction:
Count the six-membered rings in the following molecule.
C[C@@H](Oc1cccc(Cl)c1)C(=O)N1CCN(Cc2ccccn2)CC1
### Response:
3 |
ring_counting | ### Instruction:
Count the six-membered rings in the following molecule.
COc1ccc(C(=O)O[C@@H](C)c2nc3ccccc3n2C(F)F)cc1
### Response:
2 |
functional_group | ### Instruction:
Does the molecule contain a amide group?
O=C1[C@H](Sc2ccccc2)CCCN1Cc1ccccc1
### Response:
Yes |
canonicalization | ### Instruction:
Canonicalize the following SMILES string.
O=C1Nc2c(cccc2)[C@H](C(Nc2ccc(Sc3scc(n3)C)cc2)=O)C1
### Response:
Cc1csc(Sc2ccc(NC(=O)[C@@H]3CC(=O)Nc4ccccc43)cc2)n1 |
fragment_assembly | ### Instruction:
Assemble these two molecular fragments into a single molecule.
Fragment 1: [4*]C(C)C
Fragment 2: [4*]CCS([12*])(=O)=O
### Response:
CC(C)OCCS(=O)(=O)NC1CCC(Cl)CC1 |
ring_counting | ### Instruction:
Count the five-membered rings in the following molecule.
CSc1ncccc1C(=O)N1CCCc2cc(S(=O)(=O)N3CCCC3)ccc21
### Response:
1 |
fragment_assembly | ### Instruction:
Assemble these two molecular fragments into a single molecule.
Fragment 1: [9*]n1c(=O)c2c([16*])cc(C)nc2n(C)c1=O
Fragment 2: [16*]c1c(C)n(C)c2ccccc12
### Response:
COC(=O)c1cc(C)nc2c1c(=O)n(CC(=O)c1c(C)n(C)c3ccccc13)c(=O)n2C |
functional_group | ### Instruction:
Does the molecule contain a hydroxyl group?
COc1cccc(C(=O)N2CCN(c3ccccc3C)C(=O)C2)c1
### Response:
No |
ring_counting | ### Instruction:
Count the six-membered rings in the following molecule.
CC[NH2+][C@H](CC)[C@H](c1ccc(Cl)cc1)C1CC1
### Response:
1 |
chain_length | ### Instruction:
What is the length of the longest acyclic carbon chain in the molecule?
CC[C@@H](c1ccccc1)N(CC(=O)OC)C(=O)c1ccc(C#N)c(C)n1
### Response:
3 |
fragment_assembly | ### Instruction:
Assemble these two molecular fragments into a single molecule.
Fragment 1: [16*]c1c(F)cccc1Cl
Fragment 2: [8*]C[NH2+]C
### Response:
C[NH2+]C[C@@H]1C[C@@H]1c1c(F)cccc1Cl |
Subsets and Splits
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