task
stringclasses
5 values
input
stringlengths
89
339
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1ccc(CC(=O)c2cscc2Br)cc1C ### Response: 2
functional_group
### Instruction: Does the molecule contain a phenol group? Cc1c(C)n(C[C@H](O)C[NH2+]C2CCCCC2)c2ccc(F)cc12 ### Response: No
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]Cc1ccccc1[16*] Fragment 2: [1*]C(=O)[C@@H]([4*])C ### Response: C[C@@H](C(=O)Nc1ccc([N+](=O)[O-])cc1Cl)[NH+](C)Cc1ccccc1N1CCCCC1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CCc1n[nH]c(SCc2ccc(OCC(C)C)cc2)n1 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC[C@@H](Sc1n[nH]c(N)n1)C(=O)Nc1ccccc1C#N ### Response: 4
canonicalization
### Instruction: Canonicalize the following SMILES string. CC(C)c1noc(NC(=O)CN2CCOCC2)c1 ### Response: CC(C)c1cc(NC(=O)CN2CCOCC2)on1
functional_group
### Instruction: Does the molecule contain a ester group? COc1ccc([N+](=O)[O-])cc1-c1ccc(/C=C(\C#N)C(=O)Nc2cccc(Br)c2)o1 ### Response: No
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [15*][C@@H]1CC[C@H]([15*])C1 Fragment 2: [4*]Cc1cccc2cccnc12 ### Response: C[NH+](C)[C@@H]1CC[C@H](NC(=O)NCc2cccc3cccnc23)C1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1ccc(nc1Cc1cccc(F)c1)[C@@H]1C[NH+](CCC1)Cc1cccnc1 ### Response: Fc1cccc(Cc2cccc([C@H]3CCC[NH+](Cc4cccnc4)C3)n2)c1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC(C)CNC(=O)NC(=O)CSc1ncccn1 ### Response: 3
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CCc1ccsc1C[NH2+]Cc1ccccc1N1CCOCC1 ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]CCS(=O)(=O)C(C)(C)C Fragment 2: [5*]N[C@H]1C[C@H](C)[NH+](C)C1 ### Response: C[C@H]1C[C@H](NCCS(=O)(=O)C(C)(C)C)C[NH+]1C
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Cc1nn(CC(=O)Nc2nc(C[NH+]3CCCCC3)cs2)c(C)c1[N+](=O)[O-] ### Response: 1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. COc1cc(OC)c(NC(=O)[C@H](C)c2ccc(Cl)s2)cc1F ### Response: 1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Cn1cc(C(=O)N2CC[C@@H](CO)C2)c(-c2ccccc2)n1 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]CC1CC1 Fragment 2: [1*]C(=O)CC ### Response: CCC(=O)N1CCC[C@@H](C(=O)Oc2ccc(OCC3CC3)cc2)C1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1[nH+]cn(c1CN1C[C@@H]([C@H]2[NH2+]CCC2)CCC1)C(C)C ### Response: CC(C)n1c[nH+]cc1CN1CCC[C@H]([C@@H]2CCC[NH2+]2)C1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Cc1c([C@@H](C)[NH2+]CCc2cn3ccccc3[nH+]2)cnn1-c1ccccn1 ### Response: 2
functional_group
### Instruction: Does the molecule contain a amide group? Cc1ccccc1-c1cc(O)c2c(c1)CN(c1nc(-c3ccccc3)no1)CCO2 ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(ccc(c(c1)[N+](=O)[O-])O[C@H](C(NC)=O)C)C[NH2+]C(C)C ### Response: CNC(=O)[C@H](C)Oc1ccc(C[NH2+]C(C)C)cc1[N+](=O)[O-]
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)c1cccs1 Fragment 2: [1*]C(=O)[C@H]1CCCCN1[5*] ### Response: COc1ccc(-c2nc(NC(=O)[C@H]3CCCCN3C(=O)c3cccs3)sc2C)cc1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(cc(ccc1F)N1C(=O)CCC1)C(NC[C@@H](C)Oc1c(cccc1)C)=O ### Response: Cc1ccccc1O[C@H](C)CNC(=O)c1cc(N2CCCC2=O)ccc1F
canonicalization
### Instruction: Canonicalize the following SMILES string. [C@H](C)(c1cc(ccc1)O)[NH+](CC)CCS(=O)(=O)c1ccccc1 ### Response: CC[NH+](CCS(=O)(=O)c1ccccc1)[C@@H](C)c1cccc(O)c1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1c(c(n(C2CC2)c1C)C)CN1Cc2ccccc2C[C@@H]1c1oc(C)nn1 ### Response: Cc1nnc([C@H]2Cc3ccccc3CN2Cc2cc(C)n(C3CC3)c2C)o1
canonicalization
### Instruction: Canonicalize the following SMILES string. N1C(=O)N[C@](C(F)(F)F)(O)[C@H](C(=O)c2cnccc2)[C@@H]1c1ccccc1 ### Response: O=C1N[C@@H](c2ccccc2)[C@@H](C(=O)c2cccnc2)[C@](O)(C(F)(F)F)N1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Cc1csc(SCc2nc3ccccc3[nH]c2=O)n1 ### Response: 1
functional_group
### Instruction: Does the molecule contain a phenol group? CC[C@@H](C)[C@H](C)n1c(CCl)nc2cc(Br)cnc21 ### Response: No
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N1c2ccccc2OC[C@H]1C Fragment 2: [8*]C(C)(C)C ### Response: C[C@@H]1COc2ccccc2N1Cc1ncc(C(C)(C)C)o1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)c1cc(OC)cc(OC)c1 Fragment 2: [4*]CCC ### Response: CCCNC(=S)NC(=O)c1cc(OC)cc(OC)c1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. COc1cc(Cl)c(C)cc1NC(=O)C(=O)NCc1ccccc1C[NH+](C)C ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N1CC[C@H]([S@@](=O)c2cccc(Cl)c2Cl)C1 Fragment 2: [1*]C(=O)N1CC[C@H]([S@@](=O)c2cccc(Cl)c2Cl)C1 ### Response: CC(C)(C)OC(=O)N1CC[C@H]([S@@](=O)c2cccc(Cl)c2Cl)C1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]NC1CCCCC1 Fragment 2: [1*]C(=O)[C@H]1CCCN([5*])C1 ### Response: N#Cc1ccccc1S(=O)(=O)N1CCC[C@H](C(=O)NC2CCCCC2)C1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. O=C([O-])C[NH+]1CCC[C@H](CBr)C1 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [16*]c1ccc2ccccc2c1 Fragment 2: [4*]CC(=O)NNC(=O)C[8*] ### Response: COc1ccc(CC(=O)NNC(=O)COc2ccc3ccccc3c2)cc1
canonicalization
### Instruction: Canonicalize the following SMILES string. Clc1ccc(S(NC(C)C)(=O)=O)cc1OCCC ### Response: CCCOc1cc(S(=O)(=O)NC(C)C)ccc1Cl
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N(C)[C@@H](C[8*])CC Fragment 2: [14*]c1nc2nc(C)cc(C)n2n1 ### Response: CC[C@H](Cc1ccc(C)cc1)N(C)C(=O)Cc1nc2nc(C)cc(C)n2n1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Cc1c([C@@H](C)[NH2+]CCc2cn3ccccc3[nH+]2)cnn1-c1ccccn1 ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. C[C@@H](C(=O)[O-])[C@@H]([C@@H](c1cc(C)ccc1C)O)C ### Response: Cc1ccc(C)c([C@@H](O)[C@@H](C)[C@@H](C)C(=O)[O-])c1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Cc1noc(C)c1CNc1cc(Cl)ccc1C(=O)N1CCCC1 ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]Nc1nc2ccccc2nc1[14*] Fragment 2: [4*]CC[NH+](C)C ### Response: C[NH+](C)CCNc1nc2ccccc2nc1N1CCCCC1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCC(C)(C)NC(=O)[C@H](C)S(=O)(=O)c1ccccc1C ### Response: 4
canonicalization
### Instruction: Canonicalize the following SMILES string. [S@@](CCNC(=O)c1cnc(cn1)Oc1ccccc1)(=O)C ### Response: C[S@](=O)CCNC(=O)c1cnc(Oc2ccccc2)cn1
canonicalization
### Instruction: Canonicalize the following SMILES string. C(c1cc(ccc1)Cl)NC(=O)CC[C@H]1N=C(O)N(C1=O)Cc1ccccc1 ### Response: O=C(CC[C@H]1N=C(O)N(Cc2ccccc2)C1=O)NCc1cccc(Cl)c1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COc1ccc([C@H](NC(=O)N2CCc3ccc(F)cc3C2)C2CCOCC2)cc1 ### Response: 1
functional_group
### Instruction: Does the molecule contain a ether group? CCCOc1ccc(NC(=O)CNC(=O)c2ccoc2)cc1Cl ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. C(C(=O)N(CC#C)CC([O-])=O)COc1ccc(C)cc1 ### Response: C#CCN(CC(=O)[O-])C(=O)CCOc1ccc(C)cc1
canonicalization
### Instruction: Canonicalize the following SMILES string. C(C(=O)NCCn1cccc1)CC(=O)c1ccccc1 ### Response: O=C(CCC(=O)c1ccccc1)NCCn1cccc1
functional_group
### Instruction: Does the molecule contain a nitrile group? C[NH+]1CCN(C(=O)c2ccc(NC(=O)COc3ccc(F)cc3)cc2)CC1 ### Response: No
functional_group
### Instruction: Does the molecule contain a amide group? COc1ccc(OC)c(NC(=O)[C@H]2CC(=O)N(c3cc(C)cc(C)c3)C2)c1 ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. Clc1cc(Br)ccc1OCC(Nc1ccc(S(=O)(N(C)C)=O)cc1)=O ### Response: CN(C)S(=O)(=O)c1ccc(NC(=O)COc2ccc(Br)cc2Cl)cc1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Nc1cccnc1SCC(=O)N1CCc2ccccc2C1 ### Response: 2
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Cc1ccc(NC(=O)[C@H]2CCCN(c3nnc(-n4cccc4)s3)C2)c(Cl)c1 ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]C[C@@H]1CCCO1 Fragment 2: [4*]Cc1cccs1 ### Response: O=C(c1cnccn1)N(Cc1cccs1)C[C@@H]1CCCO1
functional_group
### Instruction: Does the molecule contain a ketone group? CCOc1cccc([C@@H]2CC(c3ccc(Cl)cc3)=N[C@H](c3ccc(F)cc3)[NH2+]2)c1O ### Response: No
functional_group
### Instruction: Does the molecule contain a halide group? C[C@](O)(CNC(=O)CSCc1ccncc1)c1ccc(F)cc1 ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1nn(C)c2c(N3CCCCCC3)nc(C3CC3)nc12 ### Response: 1
functional_group
### Instruction: Does the molecule contain a amine group? CCc1n[nH]c(=O)c(CNc2ccc3nnc(C)n3n2)c1CC ### Response: Yes
ring_counting
### Instruction: Count the six-membered rings in the following molecule. C[C@H](O)Cn1c(C(C)(C)C)nc2cc(Cl)ccc21 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1nnc(CCC[NH+]2CCC(CC[NH+]3CCCC[C@@H]3C)CC2)o1 ### Response: 3
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCN(CC)S(=O)(=O)N[C@@H]1CCO[C@H]1c1ccc(Cl)c(F)c1 ### Response: 2
ring_counting
### Instruction: Count the six-membered rings in the following molecule. COc1cccc(-c2cc(C(F)F)c3c(C4CC4)nn(C)c3n2)c1 ### Response: 2
ring_counting
### Instruction: Count the five-membered rings in the following molecule. COc1ccc(/C(O)=C2\C(=O)C(=O)N(CC[NH+](C)C)[C@H]2c2ccc(C)cc2)cc1C ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]Nc1nc(C)cs1 Fragment 2: [5*]N1CCN([5*])CC1 ### Response: Cc1csc(NC(=O)CN2CCN(Cc3cccs3)CC2)n1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@@H](N[C@@H]1CCCc2nc(-c3ccccc3)sc21)C(=O)N1CCOCC1 ### Response: 3
ring_counting
### Instruction: Count the six-membered rings in the following molecule. C[C@H](CSc1ccc(C(=O)N(C)C)cn1)C(=O)[O-] ### Response: 1
functional_group
### Instruction: Does the molecule contain a amide group? C[C@H](Cc1ccccc1F)C(=O)NNC(=O)CC1CCCCC1 ### Response: Yes
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CC(C)C[C@H]1NC(=O)N(CN2CC[NH+](C3CCC(C(C)C)CC3)CC2)C1=O ### Response: 1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CC(C)c1ccc(CNC(N)=[NH2+])cc1 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1ccc(C=C)cc1C[NH+]1CC[C@](C2CC2)(O)[C@@H](C1)C ### Response: C=Cc1cccc(C[NH+]2CC[C@@](O)(C3CC3)[C@H](C)C2)c1
functional_group
### Instruction: Does the molecule contain a aldehyde group? C[C@@H]1[C@H](C)CCC[C@@H]1NC(=O)Cn1nc(-c2cccc([N+](=O)[O-])c2)ccc1=O ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. C1CC[C@@]([C@H](C1)CC)([C@@](CC)(C#N)C)O ### Response: CC[C@H]1CCCC[C@]1(O)[C@](C)(C#N)CC
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [14*]c1cc([14*])on1 Fragment 2: [5*]NCC[8*] ### Response: COc1ccc(CCNC(=O)C2(c3cc(-c4ccc5c(c4)OCO5)on3)CC2)cc1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. COc1ccc(CNC(=O)c2cccc(C)c2[N+](=O)[O-])cc1 ### Response: 0
canonicalization
### Instruction: Canonicalize the following SMILES string. CC(C[C@H]1CCCCCN1C(c1cncc(c1)C)=O)C ### Response: Cc1cncc(C(=O)N2CCCCC[C@@H]2CC(C)C)c1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COc1cccc(/C=N/c2ccc(S(=O)(=O)[N-]c3nccs3)cc2)c1OC ### Response: 1
functional_group
### Instruction: Does the molecule contain a sulfonyl group? CCS(=O)(=O)c1ccccc1C(=O)Nc1ccc(-c2nc3ccccc3s2)c(O)c1 ### Response: Yes
functional_group
### Instruction: Does the molecule contain a ester group? CCn1c(CC[NH3+])nnc1Sc1ncnc2ccc(F)cc12 ### Response: No
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [7*]Cc1cccc2[nH]ccc12 Fragment 2: [1*]C(=O)C([7*])C#N ### Response: N#C/C(=C\c1cccc2[nH]ccc12)C(=O)NCc1cccnc1
functional_group
### Instruction: Does the molecule contain a amide group? CCC[C@](C)(CO)NC(=O)Nc1cc(Cl)ccc1SC ### Response: Yes
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CC(C)Oc1ccc(CCNC(=O)N[C@@H]2c3ccccc3C[C@@H]2O)cc1 ### Response: 1
functional_group
### Instruction: Does the molecule contain a amide group? C[C@@H]1CCc2nc(C[NH+]3CCC(N4CCCNC4=O)CC3)sc2C1 ### Response: Yes
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? CC(C)c1ccc2c(c1)CC[C@H]1[C@](C)(C[NH2+]CCC[NH3+])CCC[C@@]21C ### Response: Yes
functional_group
### Instruction: Does the molecule contain a amide group? CCc1nc2cc(N)ccc2n1CCC(=O)NC1CC1 ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. CC[C@@H](C[NH+](CC)Cc1cnc(N2CC[NH+](C)CC2)nc1)C ### Response: CC[C@H](C)C[NH+](CC)Cc1cnc(N2CC[NH+](C)CC2)nc1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CO[C@@H]1C[NH2+][C@@H](CN(C)CCS(C)(=O)=O)C1 ### Response: 2
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? CC(C)NC(=O)O[C@@H]1CC[C@@H]([NH3+])C1 ### Response: No
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC[C@@H](c1ccccc1)[C@@H]1CCCN1C(=O)c1cc(C#N)cs1 ### Response: 3
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(ccc(C(C)(C)NC(=O)[C@@H](C)CC)c(Cl)c1)F ### Response: CC[C@H](C)C(=O)NC(C)(C)c1ccc(F)cc1Cl
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC(=O)Nc1ccc(C(=O)Nc2nc(-c3c[nH]c4ccccc34)cs2)cc1 ### Response: 2
functional_group
### Instruction: Does the molecule contain a amine group? Cc1ccc2c(=O)cc(C(=O)N(Cc3ccccc3)c3ccccn3)oc2c1 ### Response: No
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COc1ncnc(N)c1C[NH+](C[C@@H]1C[C@@H]1C)C(C)C ### Response: 3
functional_group
### Instruction: Does the molecule contain a sulfonyl group? C/C(=C/CC[NH3+])c1ccc(Cl)cc1F ### Response: No
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]CCN[5*] Fragment 2: [1*]C(=O)[C@@H](N[5*])C(C)C ### Response: CC(=O)N[C@H](C(=O)NCC[NH+](C)C1CCCCC1)C(C)C
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [14*]c1ccco1 Fragment 2: [14*]c1n[nH]c(=S)n1/N=C\c1cccc(Br)c1 ### Response: S=c1[nH]nc(-c2ccco2)n1/N=C\c1cccc(Br)c1
canonicalization
### Instruction: Canonicalize the following SMILES string. c12c([C@H]([C@H](N(C)C2=O)c2cccs2)C(=O)Nc2ccc(C(=O)OC)cc2)cccc1 ### Response: COC(=O)c1ccc(NC(=O)[C@@H]2c3ccccc3C(=O)N(C)[C@@H]2c2cccs2)cc1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)c1ccc(O[3*])nc1 Fragment 2: [3*]OC(C)C ### Response: CC(C)Oc1ccc(C(=O)OCc2nc(C3CC3)cs2)cn1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC1CCC(CN2C[C@@H]3[C@@H](C2)OCCN3C)CC1 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. C1CC(CCC1CNC([C@@H]1CC=CCC1)=O)c1c(cnc(n1)C(C)C)-c1ccncc1 ### Response: CC(C)c1ncc(-c2ccncc2)c(C2CCC(CNC(=O)[C@@H]3CC=CCC3)CC2)n1
functional_group
### Instruction: Does the molecule contain a ester group? C=CCN(Cc1csc(COc2ccc(C)cc2)n1)C(C)=O ### Response: No
ring_counting
### Instruction: Count the five-membered rings in the following molecule. COc1ccc(C)cc1-n1ccc(C(=O)Nc2cc(C(=O)N(C)C)ccc2C)n1 ### Response: 1