task
stringclasses
5 values
input
stringlengths
89
339
functional_group
### Instruction: Does the molecule contain a amide group? C[C@H](NC(=O)NCC1([NH+](C)C)CCCCC1)c1nncn1C ### Response: Yes
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CC(C)CCNC(=O)[C@H]1CCCN(c2ccnc(-c3cccc(F)c3)n2)C1 ### Response: 3
canonicalization
### Instruction: Canonicalize the following SMILES string. C1CCC(Cc2cc(Cl)ccc2)(C([C@@H](C#N)c2scc(C)n2)=O)C1 ### Response: Cc1csc([C@H](C#N)C(=O)C2(Cc3cccc(Cl)c3)CCCC2)n1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)C1=NN([10*])C(=O)CC1 Fragment 2: [3*]Oc1ccccc1 ### Response: Cc1cccc(N2N=C(C(=O)Oc3ccccc3)CCC2=O)c1
functional_group
### Instruction: Does the molecule contain a thiol group? CC[C@H](NC(=O)C1CCOCC1)c1c(C)nn(C)c1C ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. c1c(C[NH+]2C[C@H](C[C@H](C)C2)C)c(ccc1)CN[C@H](C)c1cnc(C)s1 ### Response: Cc1ncc([C@@H](C)NCc2ccccc2C[NH+]2C[C@@H](C)C[C@H](C)C2)s1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Clc1cc(C[NH2+]C[C@@H]2CN(Cc3ccccc3)CCO2)cc2c1OCCO2 ### Response: 1
functional_group
### Instruction: Does the molecule contain a nitrile group? CCc1noc(CCN2C[C@](C)(Cc3ccc4c(c3)OCO4)CCC2=O)n1 ### Response: No
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1cc(-c2ccccc2)c(C#N)c(=O)n1C(=O)c1ccc(C#N)cc1 ### Response: 1
functional_group
### Instruction: Does the molecule contain a ether group? COc1cccc(N(CC(=O)[O-])S(=O)(=O)c2ccc(C)cc2)c1 ### Response: Yes
ring_counting
### Instruction: Count the five-membered rings in the following molecule. C#CCN1CCN([C@@H](C)C(=O)Nc2cc(F)ccc2C)CC1 ### Response: 0
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CN(Cc1ccc(N2CCCCC2)cc1)CN1C(=O)C(=O)c2ccccc21 ### Response: 3
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCOc1ccc(C(=O)NC[C@H]2CN3CCC[C@@H]3CO2)cc1 ### Response: 2
ring_counting
### Instruction: Count the six-membered rings in the following molecule. COC(=O)c1ccc(CN2CCO[C@H](C)C2)cc1F ### Response: 2
ring_counting
### Instruction: Count the five-membered rings in the following molecule. O=C1N=C(N2CCCCC2)S/C1=C1/C(=O)Nc2ccccc21 ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC[NH2+][C@H](Cc1ccc(O)cc1)[C@H]1CCc2ccccc21 ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC(C)c1[nH+]ccn1CCN1CCN(C(=O)C(C)(C)Oc2ccc(Cl)cc2)CC1 ### Response: 3
canonicalization
### Instruction: Canonicalize the following SMILES string. C(CCOC)n1c(C)cn2c1nc1c2c(n(Cc2ccccc2F)c(n1C)=O)=O ### Response: COCCCn1c(C)cn2c3c(=O)n(Cc4ccccc4F)c(=O)n(C)c3nc12
ring_counting
### Instruction: Count the six-membered rings in the following molecule. O=C(CC1CCCCC1)N1CCN(c2nc(-c3ccc(Cl)cc3)no2)CC1 ### Response: 3
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Cc1cn(-c2ccccc2)nc1NC(=O)NCCn1cccc1 ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@@H]1[C@@H]([C@@H](C)[NH2+]C[C@@H]2C=NN=C2c2ccc(Cl)cc2)C=NN1c1ccccc1 ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. Cc1c(C)oc2ncn(CC[NH+](C)C)c(c21)=[NH2+] ### Response: Cc1oc2ncn(CC[NH+](C)C)c(=[NH2+])c2c1C
functional_group
### Instruction: Does the molecule contain a amine group? Cn1cc(S(=O)(=O)N[C@@H]2C[C@@H]2c2cccc(Cl)c2)cn1 ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*][C@H]([8*])CN[5*] Fragment 2: [1*]C(=O)C([1*])=O ### Response: COc1ccccc1NC(=O)C(=O)NC[C@@H](c1cccnc1)N1CCc2ccccc2C1
canonicalization
### Instruction: Canonicalize the following SMILES string. C1C(=O)Nc2n3ncnc3nc(c2[C@H]1c1cc2c(OCO2)cc1)[O-] ### Response: O=C1C[C@H](c2ccc3c(c2)OCO3)c2c([O-])nc3ncnn3c2N1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COCCn1ccc2cc(C(=O)N[C@H](C)c3nnc4ccccn34)ccc21 ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N1CCCCC1 Fragment 2: [8*]CC[NH3+] ### Response: [NH3+]CCc1ccc(N2CCCCC2)cc1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCOc1cc2oc(=O)cc(C)c2cc1CC ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1cc(C(=O)N(C)C)sc1C ### Response: 1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Cc1ccccc1CNc1ccc(C(=O)[O-])c(F)c1F ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. C[C@@H](C(=O)NCCc1ccc(cc1)F)Sc1c2c(nc(C)n1)cccc2 ### Response: Cc1nc(S[C@@H](C)C(=O)NCCc2ccc(F)cc2)c2ccccc2n1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1ccc(C(=O)NC[C@H](C)C#N)cc1Cl ### Response: 3
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)c1ccc(F)c(OC)c1 Fragment 2: [5*]N[C@@H](CCC)C(=O)OC ### Response: CCC[C@H](NC(=O)c1ccc(F)c(OC)c1)C(=O)OC
ring_counting
### Instruction: Count the five-membered rings in the following molecule. COC(=O)C1=NC2=C(C(=O)C[C@@H](c3cc(OC)c(OC)c(OC)c3)C2)[C@H]1C ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]NCc1ccc(C)c(F)c1 Fragment 2: [1*]C(=O)C[4*] ### Response: COC[C@H](C)[NH+]1CCN(CC(=O)NCc2ccc(C)c(F)c2)CC1
canonicalization
### Instruction: Canonicalize the following SMILES string. C1N(CC(=O)N2CCC(c3nc(C)on3)CC2)C(OCC1)=O ### Response: Cc1nc(C2CCN(C(=O)CN3CCCOC3=O)CC2)no1
functional_group
### Instruction: Does the molecule contain a carboxyl group? [O-]/C(Cc1ccc(F)c(F)c1)=N\c1nc(-c2ccco2)n[nH]1 ### Response: No
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CC(=O)Nc1ccc(F)c(C(=O)Nc2ccccc2Br)c1 ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)c1occc1C Fragment 2: [4*]CCCN[5*] ### Response: COc1ccc2c(c1)[C@@H]([NH2+]CCCNC(=O)c1occc1C)CCCO2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COCCC[NH+](Cc1ccc(F)cc1Cl)[C@H]1CCS(=O)(=O)C1 ### Response: 3
canonicalization
### Instruction: Canonicalize the following SMILES string. CC(C)(NC(=O)[C@H](Oc1cnc(cc1)C[C@H](C)[NH3+])C)CC ### Response: CCC(C)(C)NC(=O)[C@@H](C)Oc1ccc(C[C@H](C)[NH3+])nc1
functional_group
### Instruction: Does the molecule contain a ester group? COc1ccc(NS(=O)(=O)CCc2ccccc2)cn1 ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. CC1C(N2CCC(CC2)C(=O)NCCC)=NS(=O)(C=1c1ccc(cc1)OC)=O ### Response: CCCNC(=O)C1CCN(C2=NS(=O)(=O)C(c3ccc(OC)cc3)=C2C)CC1
canonicalization
### Instruction: Canonicalize the following SMILES string. CC[NH2+]CCc1c2c(c(ccc2)Cl)[nH]c1 ### Response: CC[NH2+]CCc1c[nH]c2c(Cl)cccc12
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CCOCCN(C)C(=O)Nc1ccc(Sc2nnc(C)s2)cc1C ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*][C@@H](C)C1CC1 Fragment 2: [5*]Nc1nccc([14*])n1 ### Response: C[C@H](Nc1nccc(CCC(F)(F)F)n1)C1CC1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C=C(C)C[C@@H](O)[C@]1([NH+](C)C)CCC[C@@H](C)C1 ### Response: 4
ring_counting
### Instruction: Count the five-membered rings in the following molecule. COCCOc1c(Cl)cccc1NC(=O)Cc1c[nH]c2ccccc12 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1cccc(C)c1NC(=O)CCCN1CCOC[C@@H]1C1CC1 ### Response: 4
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? Cc1ccc(C(=O)N/C(=C/c2ccccc2Cl)C(=O)NCc2ccccc2)cc1 ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)[C@H]1CC=CC[C@H]1[15*] Fragment 2: [6*]C(=O)[O-] ### Response: O=C(NC1COC1)[C@H]1CC=CC[C@H]1C(=O)[O-]
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [14*]c1nc(N)sc1Br Fragment 2: [16*]c1cccc(F)c1 ### Response: Nc1nc(-c2cccc(F)c2)c(Br)s1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=S(=O)(/N=C(\[O-])CCc1ncc(-c2ccccc2)o1)C1CCCC1 ### Response: 3
functional_group
### Instruction: Does the molecule contain a nitrile group? C[C@]1(C(N)=O)Oc2ccc(Cl)cc2NC1=O ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. n1(-c2ccc(cc2)C(N[C@H](c2cccc(OC)c2)CO)=O)cccc1 ### Response: COc1cccc([C@H](CO)NC(=O)c2ccc(-n3cccc3)cc2)c1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CSc1cccc(NC(=O)c2cc(C)c(Br)s2)c1 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. Cc1c(cc(C)s1)[C@@H](NC(=O)C(Nc1cc(c(C)cc1)F)=O)C ### Response: Cc1cc([C@H](C)NC(=O)C(=O)Nc2ccc(C)c(F)c2)c(C)s1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CC[NH+](CC(=O)Nc1c(C)cccc1C)Cc1cccnc1C ### Response: 0
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)c1cccc([16*])c1 Fragment 2: [3*]Oc1ccc(C)cc1[N+](=O)[O-] ### Response: COCc1cccc(C(=O)Oc2ccc(C)cc2[N+](=O)[O-])c1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COc1ccc(NC(=O)N2CCC[C@H]2c2nc(-c3ccccc3OC)no2)cc1F ### Response: 1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Cc1ccc(-c2csc(NC(=O)C3=NN(c4ccc(F)cc4)[C@@H](C(N)=O)C3)n2)c(C)c1 ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. c1ccc2cccnc2c1SCc1cn2cccnc2n1 ### Response: c1cnc2c(SCc3cn4cccnc4n3)cccc2c1
functional_group
### Instruction: Does the molecule contain a amine group? CC[NH+]1CCC[C@@H]1CNC(=O)N1CCC[C@H]([NH+](C)C)C1 ### Response: No
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N1C[C@@H](C)C[C@H]([NH3+])C1 Fragment 2: [1*]C(=O)c1cc2c(s1)CCC2 ### Response: C[C@H]1C[C@H]([NH3+])CN(C(=O)c2cc3c(s2)CCC3)C1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(C)cccc(CC(N2[C@@H](c3c(cnn3C)-c3onc(C)c3C)CCCC2)=O)c1 ### Response: Cc1cccc(CC(=O)N2CCCC[C@@H]2c2c(-c3onc(C)c3C)cnn2C)c1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(cc(C)ccc1NC(/C=C/c1ccc(C)o1)=O)C ### Response: Cc1ccc(NC(=O)/C=C/c2ccc(C)o2)c(C)c1
functional_group
### Instruction: Does the molecule contain a ether group? CCOC(=O)[C@@H](C(C)C)[C@H](O)c1cnn(C)c1C ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)c1ccccc1O Fragment 2: [1*]C(=O)CO[3*] ### Response: O=C1CN(C(=O)COC(=O)c2ccccc2O)c2ccccc2N1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [12*]S(=O)(=O)c1cc([16*])ccc1OC Fragment 2: [8*]C(C)C ### Response: COc1ccc(C(C)C)cc1S(=O)(=O)N1CCc2ccccc21
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1ccc(NC(=O)c2noc3c2CCCCC3)c(Cl)c1 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@H](C1CCCCC1)[C@@H](C)NC(=O)[C@@H](C)NS(=O)(=O)c1cnn(C)c1 ### Response: 4
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)[C@H]([4*])C Fragment 2: [3*]OCC ### Response: CCOC(=O)[C@@H](C)N(CC)Cc1ccccn1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N1CCC[C@H]([15*])C1 Fragment 2: [1*]C(=O)[C@H]([8*])CN[5*] ### Response: C[NH+](C)[C@H]1CCCN(C(=O)[C@@H](CNC(=O)OC(C)(C)C)c2ccccc2)C1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]CC(C)C Fragment 2: [5*]N1CCC[C@H](C)C1 ### Response: CC(C)C[NH+]1CCC(C(=O)N2CCC[C@H](C)C2)CC1
canonicalization
### Instruction: Canonicalize the following SMILES string. [C@H](c1ccccc1Cl)(C)NC1[C@H]2N=CN=C2N=CN=1 ### Response: C[C@@H](NC1=NC=NC2=NC=N[C@@H]21)c1ccccc1Cl
canonicalization
### Instruction: Canonicalize the following SMILES string. n1cnn(-c2c(cccn2)CNS(CC2CCC2)(=O)=O)c1 ### Response: O=S(=O)(CC1CCC1)NCc1cccnc1-n1cncn1
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? Cc1oc2cc3oc(=O)c(CCC(=O)N4CCc5ccccc5C4)c(C)c3cc2c1C ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CN(C)C(=O)N1CCN(CC#N)CC1 ### Response: 2
functional_group
### Instruction: Does the molecule contain a thiol group? Cc1cccc(NC(=O)CNC(=O)c2nn(-c3ccccc3Cl)c(C)cc2=O)c1C ### Response: No
ring_counting
### Instruction: Count the five-membered rings in the following molecule. O=C1N[C@H](c2cccc(Oc3ccccc3)c2)Oc2ccccc21 ### Response: 0
canonicalization
### Instruction: Canonicalize the following SMILES string. c1coc(c1)CNC(c1ccc(NC(=O)COc2cc(ccc2C)C)cc1)=O ### Response: Cc1ccc(C)c(OCC(=O)Nc2ccc(C(=O)NCc3ccco3)cc2)c1
canonicalization
### Instruction: Canonicalize the following SMILES string. C1Oc2cc(N3CCN(CC(Nc4nc(C)ccc4)=O)C3=O)ccc2OC1 ### Response: Cc1cccc(NC(=O)CN2CCN(c3ccc4c(c3)OCCO4)C2=O)n1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CC(C)[C@H](O)CCNC(=O)Nc1ncn(Cc2ccc(C#N)cc2)n1 ### Response: 1
functional_group
### Instruction: Does the molecule contain a halide group? COC[C@H](C)[NH+]1CCN(CC(=O)NCc2ccc(C)c(F)c2)CC1 ### Response: Yes
functional_group
### Instruction: Does the molecule contain a nitro group? C[C@@H]1CSC(SCc2nc(-c3cccs3)n[nH]2)=N1 ### Response: No
functional_group
### Instruction: Does the molecule contain a carboxyl group? O=C(C1CCN(C[C@@H]2CCC[NH+]3CCCC[C@@H]23)CC1)N1CCCC1 ### Response: No
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Cn1cc(C(=O)Nc2ccc(-n3ccnn3)cc2)c(C(C)(C)C)n1 ### Response: 2
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CC[NH2+][C@@H](C)c1ccnc(Oc2ccccc2C(N)=O)c1 ### Response: 0
canonicalization
### Instruction: Canonicalize the following SMILES string. C1(=O)N(C[C@H](C(=O)Nc2c3[C@H](c4ccccc4)CC(=O)Nc3n(C)n2)C1)c1ccc(F)cc1 ### Response: Cn1nc(NC(=O)[C@@H]2CC(=O)N(c3ccc(F)cc3)C2)c2c1NC(=O)C[C@H]2c1ccccc1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C1CCCN1[C@H]1CCC[NH+](Cc2ccc(OC(F)F)c(Cl)c2)C1 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. FC(F)(c1cc(ccc1F)-c1cnc(c(c1)C([O-])=O)O)F ### Response: O=C([O-])c1cc(-c2ccc(F)c(C(F)(F)F)c2)cnc1O
canonicalization
### Instruction: Canonicalize the following SMILES string. N(c1cc(C)cc(c1)C)C(=O)C(=O)NCCc1sc2c(n1)cccc2 ### Response: Cc1cc(C)cc(NC(=O)C(=O)NCCc2nc3ccccc3s2)c1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [11*]Sc1nc(N)cc(N)n1 Fragment 2: [1*]C(=O)[C@H]([4*])C ### Response: Cc1ccc(NC(=O)[C@@H](C)Sc2nc(N)cc(N)n2)c(F)c1
functional_group
### Instruction: Does the molecule contain a ester group? COC(=O)[C@@H](O)C1CC[NH+](CC[NH+](C)C)CC1 ### Response: Yes
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Cn1cnc2c1c(=O)n(CCCSc1nnc(N3CCCC3)n1C1CC1)c(=O)n2C ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C1NC2(CCN(C(=O)[C@@H]3CC(=O)N(C4CCCCC4)C3)CC2)Nc2ccccc21 ### Response: 1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CC1CC(=O)N(C[C@@H]2CC[C@H](C(=O)NN)O2)C(=O)C1 ### Response: 1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CCCCCNC(=O)[C@H](C)Oc1ccc(C#N)c(F)c1 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. C1CC(C)CCC1NC(C(=O)Nc1ccc(cc1C)N1CCOCC1)=O ### Response: Cc1cc(N2CCOCC2)ccc1NC(=O)C(=O)NC1CCC(C)CC1
functional_group
### Instruction: Does the molecule contain a halide group? C[C@@H](CC(F)(F)F)[NH2+]CCc1nc(-c2ccccn2)cs1 ### Response: Yes