task
stringclasses
5 values
input
stringlengths
89
339
ring_counting
### Instruction: Count the five-membered rings in the following molecule. COc1ccc2cc([C@@H]([NH3+])CO)ccc2c1 ### Response: 0
functional_group
### Instruction: Does the molecule contain a sulfonyl group? CCNC(=O)[C@@H]1CCC(=O)N(c2ccc(C)cc2)[C@H]1c1cccs1 ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. Oc1ccc(OC)cc1NC(NC(c1cc(C)c(C)cc1)=O)=S ### Response: COc1ccc(O)c(NC(=S)NC(=O)c2ccc(C)c(C)c2)c1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1n(-c2ccccc2)nc(CN2C(C[C@](C)(C2=O)C(C)C)=O)n1 ### Response: CC(C)[C@]1(C)CC(=O)N(Cc2ncn(-c3ccccc3)n2)C1=O
canonicalization
### Instruction: Canonicalize the following SMILES string. O=[N+]([O-])c1c(NC(COC(=O)/C=C/C)=O)cccc1 ### Response: C/C=C/C(=O)OCC(=O)Nc1ccccc1[N+](=O)[O-]
canonicalization
### Instruction: Canonicalize the following SMILES string. C(=C)CCO[C@@H](C(N1C[C@@H](N(C(OC(C)(C)C)=O)C[C@@H]1C)C)=O)C ### Response: C=CCCO[C@H](C)C(=O)N1C[C@H](C)N(C(=O)OC(C)(C)C)C[C@@H]1C
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [13*][C@@]1(C)C[NH+]=C(N)N1C Fragment 2: [8*]COC ### Response: COC[C@@]1(C)C[NH+]=C(N)N1C
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N(C)C[8*] Fragment 2: [1*]C(C)=O ### Response: CCn1ccnc(Nc2cccc(CN(C)C(C)=O)c2)c1=O
functional_group
### Instruction: Does the molecule contain a ether group? Cn1cncc1C(=O)Nc1ccc(OC(=O)c2ccnn2C)cc1 ### Response: Yes
ring_counting
### Instruction: Count the five-membered rings in the following molecule. C[NH+]1CCN(c2ncc3c(n2)CCN(Cc2cccc(Cl)c2)C3)CC1 ### Response: 0
functional_group
### Instruction: Does the molecule contain a ether group? Cc1cccc(C)c1OCCn1cc(/C=C2/C(=O)NC(=O)N(c3ccc(F)cc3)C2=O)c2ccccc21 ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. n1c(cccc1)CC([C@@H]1CN(CCO1)C)=O ### Response: CN1CCO[C@H](C(=O)Cc2ccccn2)C1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. COc1ccc(-c2cc(C(=O)NCC3CCOCC3)on2)cc1 ### Response: 2
functional_group
### Instruction: Does the molecule contain a ether group? CCOc1ccc(N2C(=O)[C@@H](CC)S/C2=C(/C#N)C(=O)Nc2ccccc2OC)cc1 ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. c1c(nc(o1)C)C(=O)N1[C@H](CCC1)c1ncccc1 ### Response: Cc1nc(C(=O)N2CCC[C@@H]2c2ccccn2)co1
functional_group
### Instruction: Does the molecule contain a halide group? C[NH+](CCC#N)CC(=O)Nc1ccc(OC(F)F)c(Cl)c1 ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. C(F)(S(=O)(c1cc([N+](=O)[O-])c(N[C@@H]([C@H](CO)C)C)cc1)=O)F ### Response: C[C@@H](CO)[C@@H](C)Nc1ccc(S(=O)(=O)C(F)F)cc1[N+](=O)[O-]
functional_group
### Instruction: Does the molecule contain a sulfonyl group? O=c1c(-c2nccs2)nc2ccc(NCc3c(F)cccc3F)nc2n1Cc1ccncc1 ### Response: No
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CCCNc1cc[nH+]c(COc2ccc(F)c(F)c2)c1 ### Response: 0
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [9*]n1cncn1 Fragment 2: [1*]C(=O)c1ccc([16*])cc1C ### Response: Cc1cc(-n2cncn2)ccc1C(=O)Nc1ncnc2oc(C)c(C)c12
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1ccc(NC(=O)NCc2ccccc2S(=O)(=O)N(C)C)cc1 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [9*]n1ccc2nc3ncnn3c([14*])c2c1=O Fragment 2: [8*]C(F)(F)F ### Response: O=c1c2c(-c3ccccc3)n3ncnc3nc2ccn1-c1cccc(C(F)(F)F)c1
functional_group
### Instruction: Does the molecule contain a sulfonyl group? C[C@H]1CCCN(C(=O)C2CC[NH+](C[C@@H](O)c3ccc(F)cc3F)CC2)C1 ### Response: No
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]Nc1c([16*])cc([N+](=O)[O-])cc1[N+](=O)[O-] Fragment 2: [4*]C(C)(C)C ### Response: CC(C)(C)Nc1c(C(N)=O)cc([N+](=O)[O-])cc1[N+](=O)[O-]
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [14*]c1cc2ccccc2o1 Fragment 2: [1*]C(=O)CCCS(=O)(=O)c1ccc(F)cc1 ### Response: O=C(CCCS(=O)(=O)c1ccc(F)cc1)Nc1nnc(-c2cc3ccccc3o2)o1
canonicalization
### Instruction: Canonicalize the following SMILES string. O=C(N1CCC(CC1)OC)CCCOC ### Response: COCCCC(=O)N1CCC(OC)CC1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]NC[C@@H]1CC(=O)N(C[8*])C1 Fragment 2: [1*]C(=O)c1ccc2nnc(C)n2c1 ### Response: Cc1nnc2ccc(C(=O)NC[C@@H]3CC(=O)N(Cc4ccccc4)C3)cn12
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Cc1cc2c(o1)CC(C)(C)C[C@H]2NC(=O)N1CCN(c2ncccn2)CC1 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. C(Nc1sccn1)(=O)CSCc1[nH]c(=O)c2c3c(CCCC3)sc2n1 ### Response: O=C(CSCc1nc2sc3c(c2c(=O)[nH]1)CCCC3)Nc1nccs1
functional_group
### Instruction: Does the molecule contain a ether group? C[C@@H](Oc1ccc(-c2ccccc2)cc1)C(=O)N(C)Cc1ccccc1 ### Response: Yes
functional_group
### Instruction: Does the molecule contain a halide group? C[C@@H](CC(=O)N1CCOCC1)[NH2+]CCOc1ncccc1Cl ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [14*]c1ccco1 Fragment 2: [1*]C(=O)C[8*] ### Response: C[C@H](NC(=O)Cn1nnc(-c2ccsc2)n1)c1ccco1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Cc1cc(NC(=O)CCNC(=O)c2ccco2)n(Cc2ccccn2)n1 ### Response: 2
ring_counting
### Instruction: Count the five-membered rings in the following molecule. O=C([C@H]1CC12CCC2)N1CCc2onc(-c3ccc4c(c3)OCO4)c2C1 ### Response: 2
ring_counting
### Instruction: Count the five-membered rings in the following molecule. C[NH+](C)C[C@H](NC(=O)c1ccc(=O)n(Cc2ccccc2Cl)c1)c1ccccc1 ### Response: 0
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CNC(=O)c1cc(NC(=O)CCOc2cc(C)cc(C)c2)ccc1Cl ### Response: 3
ring_counting
### Instruction: Count the six-membered rings in the following molecule. COc1ccc(C(=O)COC(=O)c2cccc(S(C)(=O)=O)c2)cc1 ### Response: 2
ring_counting
### Instruction: Count the six-membered rings in the following molecule. C[C@@H](O)CCNC(=O)NC[C@H](C)Oc1cccc(Cl)c1 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@@H]1C[NH+](Cc2ccccn2)CC[C@@H]1NC(=O)N[C@@H](C)CCC(C)(C)C ### Response: 6
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [16*]c1ccccc1Br Fragment 2: [1*]C(=O)N[5*] ### Response: CC[C@@H](C)NC(=O)Nc1ccccc1Br
ring_counting
### Instruction: Count the five-membered rings in the following molecule. COc1ccc(NC(=O)N2CCC3(CC2)OCCN3S(=O)(=O)c2ccc(C)cc2)cc1OC ### Response: 1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. C[C@@]1(C(=O)NCc2ccc(F)cc2)Cn2nc(-c3cccs3)cc2C(=O)N1c1ccc(F)cc1 ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)c1cccc([14*])n1 Fragment 2: [16*]c1ccccc1 ### Response: COCCNC(=O)c1cccc(N2CC[NH2+][C@@H](c3ccccc3)C2)n1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. O=S(=O)(C[C@@H]1CCCO1)N1CCC[C@H]1[C@@H]1CCC[C@@H]1O ### Response: 0
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(nc([C@H](NS(c2ccc(OC)cc2)(=O)=O)C(C)C)on1)-c1ccncc1 ### Response: COc1ccc(S(=O)(=O)N[C@@H](c2nc(-c3ccncc3)no2)C(C)C)cc1
canonicalization
### Instruction: Canonicalize the following SMILES string. C([NH+]1C[C@@H](C)C[C@@H](C1)C)[C@H](NC(NNC(Cc1ccccc1OC)=O)=O)C ### Response: COc1ccccc1CC(=O)NNC(=O)N[C@H](C)C[NH+]1C[C@@H](C)C[C@H](C)C1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]Nc1ncccn1 Fragment 2: [5*][NH+]1CCC([15*])CC1 ### Response: C[C@@H](C(=O)Nc1ncccn1)[NH+]1CCC(c2ccc(O)cc2)CC1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)C1CCN(C([1*])=O)CC1 Fragment 2: [1*]C(=O)C1CCN([5*])CC1 ### Response: CCC1(CC)[C@@H](NC(=O)N2CCC(C(=O)N(C)C(C)C)CC2)[C@H](C)[C@@H]1OC
ring_counting
### Instruction: Count the six-membered rings in the following molecule. COC(=O)c1cc(NC(=O)CSc2nnnn2-c2ccccc2)ccc1Cl ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. C1C[C@@H](C[C@@H]1NC(=O)NCC1CC[NH+](C)CC1)[NH+](C)C ### Response: C[NH+]1CCC(CNC(=O)N[C@@H]2CC[C@H]([NH+](C)C)C2)CC1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N[C@@H]1CCN([10*])C1=O Fragment 2: [10*]N1CCCC1=O ### Response: CC(C)[C@H](C(=O)N[C@@H]1CCN(c2ccccc2)C1=O)N1CCCC1=O
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [6*]C(=O)NNC(=O)C[8*] Fragment 2: [16*]c1ccccc1F ### Response: O=C(Cc1ccccc1F)NNC(=O)c1c[nH]c2cccc(F)c12
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C/C(=C/C(=O)N1CCN(CC(=O)NC(C)C)CC1)C(C)(C)C ### Response: 5
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [8*]C[C@@H](C)C(C)=O Fragment 2: [9*]n1cnc2c(C)cccc2c1=O ### Response: CC(=O)[C@H](C)Cn1cnc2c(C)cccc2c1=O
functional_group
### Instruction: Does the molecule contain a amine group? C[C@@H]1OCC[C@@H]1C(=O)NCC1(c2cccc(C(F)(F)F)c2)CCOCC1 ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. C(NC(=O)NCC)[C@@H]1[NH+](CCCC1)Cc1ccccc1 ### Response: CCNC(=O)NC[C@H]1CCCC[NH+]1Cc1ccccc1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(ncc(cn1)C(=O)N1CCC2(CC1)CCCO2)-c1cccnc1 ### Response: O=C(c1cnc(-c2cccnc2)nc1)N1CCC2(CCCO2)CC1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COc1ccc(-n2c(SCC(N)=O)nc3ccccc3c2=O)cc1Cl ### Response: 2
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Cc1cccn2c(=O)c(C(=O)N3CCC[C@@H]3C[NH+]3CCCCC3)cnc12 ### Response: 1
functional_group
### Instruction: Does the molecule contain a amide group? CCn1c(SCC(=O)N2CCCC[C@@H]2C)nnc1-c1ccncc1 ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)c1ccc(C[4*])cc1 Fragment 2: [5*]N1CCC([15*])CC1 ### Response: O=C(c1ccc(CNS(=O)(=O)c2ccccc2)cc1)N1CCC(Cc2ccccc2)CC1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [8*]CC1CC1 Fragment 2: [14*]c1nc(C)cc(C)c1C#N ### Response: Cc1cc(C)c(C#N)c(N2C[C@@H]3CC[C@H](C2)N(CC2CC2)C3=O)n1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)C[4*] Fragment 2: [5*]NCc1ccccc1C ### Response: Cc1ccccc1CNC(=O)CO/N=C(\N)c1cccc(C(F)(F)F)c1
functional_group
### Instruction: Does the molecule contain a amide group? O=C(CCc1cccc(F)c1F)NC[C@@H](O)c1ccc(Cl)cc1 ### Response: Yes
ring_counting
### Instruction: Count the five-membered rings in the following molecule. O=C(Cc1coc(-c2ccccc2)n1)Oc1ccccc1 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CN(C)c1ccc(/C=C2\SC(=N)N(c3ccc(Cl)cc3Cl)C2=O)cc1[N+](=O)[O-] ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[NH2+]CC/C=C/C[C@H]1C[C@H]2CC[C@@H]1C2 ### Response: 5
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N[C@H](C)COC Fragment 2: [16*]c1ccccc1Cl ### Response: COC[C@@H](C)NC(=O)c1c[nH]nc1-c1ccccc1Cl
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC(=O)Nc1cccc(N[C@H](C)C(=O)NC[C@H](C)c2ccccc2)c1C ### Response: 3
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@H]1C[C@@H]1C(=O)Nc1ccc(-c2nc3ccccc3s2)cc1 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. n1c(nc(C(C)(C)C)[nH]1)C(N[C@@H]1CCCCC[C@H]1[NH3+])=O ### Response: CC(C)(C)c1nc(C(=O)N[C@@H]2CCCCC[C@H]2[NH3+])n[nH]1
functional_group
### Instruction: Does the molecule contain a amide group? Cc1cccc(N2CCN(C(=O)c3cc(C4CC4)on3)CC2)c1 ### Response: Yes
functional_group
### Instruction: Does the molecule contain a aldehyde group? CCSc1cccc(C(=O)Nc2cccc3c2C(=O)N(C)C3=O)c1 ### Response: No
functional_group
### Instruction: Does the molecule contain a ether group? CCCC1CN([C@@H]2[C@@H]([NH3+])[C@H]3CCO[C@@H]32)C1 ### Response: Yes
functional_group
### Instruction: Does the molecule contain a phenol group? O=C(NCCCS(=O)(=O)c1ccccc1)c1n[nH]c2ccccc12 ### Response: No
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC1CCN(S(=O)(=O)c2ccccc2-c2ccno2)CC1 ### Response: 1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. COC(C)(C)C[C@@H](C)NC(=O)NC1CCC(O)CC1 ### Response: 0
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC[C@H](CCO)CNc1nc2ccc(C)cn2n1 ### Response: 5
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Cc1cc(Br)ccc1SCC(=O)N1CCC(C(=O)c2ccc3c(c2)OCCO3)CC1 ### Response: 0
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CN(C)C1=C(C(=O)Nc2ccccc2)CSc2ccccc21 ### Response: 3
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]Nc1cc([14*])nn1C Fragment 2: [1*]C(=O)C([1*])=O ### Response: CCCc1cc(NC(=O)C(=O)N[C@H](C)c2cc(C)c(CC)s2)n(C)n1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. COc1ccc([C@H]2C(C(=O)c3cc4ccccc4o3)=C([O-])C(=O)N2Cc2ccco2)cc1OC ### Response: 2
functional_group
### Instruction: Does the molecule contain a amide group? C[C@@H]1c2cc(F)ccc2CCN1C(=O)[C@H]1CCC[NH+](C)C1 ### Response: Yes
functional_group
### Instruction: Does the molecule contain a phenol group? COc1cccc(Cc2noc(C[C@H]3C[NH2+]CCO3)n2)c1 ### Response: No
ring_counting
### Instruction: Count the six-membered rings in the following molecule. c1nc(N2CCC[C@H]([NH+]3CCCC3)C2)c2ccsc2n1 ### Response: 2
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CC(C)(C)OC1CCN(Cc2[nH]cc(-c3cccc(Br)c3)[nH+]2)CC1 ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)C[NH+]([5*])C Fragment 2: [16*]c1ccc2c(c1)OCCO2 ### Response: Cc1oc(NC(=O)C[NH+](C)Cc2ccc3c(c2)OCCO3)c(C#N)c1C
functional_group
### Instruction: Does the molecule contain a hydroxyl group? COc1ccc2c([C@@H](O)C[NH+]3CCC4(CC3)C[C@@H](O)c3ccccc3O4)c[nH]c2c1 ### Response: Yes
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CNC(=O)CCc1cccc([C@H]2CCC[NH+]2C(C)C)n1 ### Response: 1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CN(CC(=O)NC(C)(C)CC(C)(C)C)C1=NS(=O)(=O)c2ccccc21 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [8*]Cc1ccc(Br)cc1 Fragment 2: [14*]c1cccs1 ### Response: O=C(CCc1nc(-c2cccs2)no1)Nc1ccnn1Cc1ccc(Br)cc1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1cc(OCC(=O)NCCCNC(=O)c2cccs2)ccc1Cl ### Response: 3
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COc1cc(=O)n(-c2ccccc2)nc1C(=O)Nc1ccccc1SC ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@@H]1CN(C(=O)[C@H]2CC(=O)N(C)[C@@H]2c2cccnc2)CCO1 ### Response: 1
functional_group
### Instruction: Does the molecule contain a nitro group? C[C@H](CNc1ccccc1F)Oc1ccccc1Cl ### Response: No
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CCN(c1ccc(C[NH2+]C)cc1F)C(C)C ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. O=C(C[C@@H](C1CC1)NC(c1ccc2c(c1)c(c([nH]2)C)C)=O)OC ### Response: COC(=O)C[C@H](NC(=O)c1ccc2[nH]c(C)c(C)c2c1)C1CC1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CC[NH2+]Cc1cn(C)nc1-c1cc(F)c(C)cc1F ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C(N[C@H]1[C@H](O)[C@H](O)C[C@@H]1C1CCCCC1)c1cccnc1 ### Response: 1
functional_group
### Instruction: Does the molecule contain a phenol group? Cc1ccc(NC(=O)CSc2nnc(-c3ccc(C)cc3)n2C)cc1 ### Response: No