task
stringclasses
5 values
input
stringlengths
89
339
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Clc1ccc(C2([NH2+]C3CCCC3)CCOCC2)cc1 ### Response: 0
functional_group
### Instruction: Does the molecule contain a sulfonyl group? N#CC(C#N)[C@@H](CC(=O)c1ccc(Cl)cc1)c1cccs1 ### Response: No
functional_group
### Instruction: Does the molecule contain a nitro group? COc1ccc(SCC(=O)c2ccc(C)c(C)c2)cc1 ### Response: No
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [15*][C@H]1CCCC[C@H]1CC Fragment 2: [9*]n1c(N)nc2c(OC)ncnc21 ### Response: CC[C@@H]1CCCC[C@@H]1n1c(N)nc2c(OC)ncnc21
functional_group
### Instruction: Does the molecule contain a thiol group? CCc1nn(C)cc1C(=O)N(C)CC(=O)Nc1cccc(C)n1 ### Response: No
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Cn1c(-c2ccco2)nn(C[NH+](C)CCc2ccccc2)c1=S ### Response: 2
functional_group
### Instruction: Does the molecule contain a thiol group? CCNC(=O)[C@H]1CCCN(C(=O)C=C(C2CC2)C2CC2)C1 ### Response: No
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Brc1ccc2nc(C[C@@H]3CCC[NH2+]C3)sc2c1 ### Response: 1
functional_group
### Instruction: Does the molecule contain a phenol group? O=C(C[C@@H](c1ccc(F)cc1)c1ccco1)NCc1ccco1 ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. C1N(C(C)(C)CC1)C(NCCc1cc(C(N)=O)ccc1)=O ### Response: CC1(C)CCCN1C(=O)NCCc1cccc(C(N)=O)c1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]NCc1nc2ccccc2n1CC Fragment 2: [1*]C(=O)C[8*] ### Response: CCn1c(CNC(=O)Cc2cccc(OC)c2)nc2ccccc21
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[NH+]1CCN(C(C)(C)C(=O)NCC(C)(C)c2ccc(Cl)cc2)CC1 ### Response: 3
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1ccc(NC(=O)N2CC[C@H](C)[C@@H](O)C2)cc1OCC(F)F ### Response: 2
ring_counting
### Instruction: Count the six-membered rings in the following molecule. COc1ccc(CC(=O)N2CCN(S(=O)(=O)c3ccc4c(c3)sc(=O)n4C)CC2)cc1OC ### Response: 3
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [9*]n1c(=O)/c(=C/c2ccc(F)c(F)c2)s/c1=C(/C#N)C(=O)NC Fragment 2: [16*]c1ccccc1 ### Response: CNC(=O)/C(C#N)=c1\s/c(=C\c2ccc(F)c(F)c2)c(=O)n1-c1ccccc1
canonicalization
### Instruction: Canonicalize the following SMILES string. O=C(Nc1c(C#N)cccc1)[C@H](C)OC(=O)c1ccc2c(nnn2CC)c1 ### Response: CCn1nnc2cc(C(=O)O[C@@H](C)C(=O)Nc3ccccc3C#N)ccc21
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C1c2ccccc2C(=O)c2c1cc(F)c1ccccc21 ### Response: 0
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? CC[C@@H]([NH2+][C@H](C)c1cc(Cl)cc(Cl)c1)c1c(C)noc1C ### Response: Yes
ring_counting
### Instruction: Count the six-membered rings in the following molecule. C[C@@H](O)CC(C)(C)CNC(=O)/C=C/c1cccnc1 ### Response: 1
functional_group
### Instruction: Does the molecule contain a halide group? O=C(Nc1ccccc1)c1cc(Br)cn(Cc2cccc(C(F)(F)F)c2)c1=O ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)c1ccc(F)c(Cl)c1 Fragment 2: [5*]N1C[C@@H](C)NC(=O)c2ccc(F)cc21 ### Response: C[C@@H]1CN(C(=O)c2ccc(F)c(Cl)c2)c2cc(F)ccc2C(=O)N1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [15*][C@@H]1CCC[C@]([15*])(NC)C1 Fragment 2: [4*]CCC ### Response: CCCN1CC[NH+]([C@@H]2CCC[C@@](NC)(C(N)=O)C2)CC1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC(C)(C)OC(=O)C1CCC(Nc2ccc([N+](=O)[O-])nc2)CC1 ### Response: 3
functional_group
### Instruction: Does the molecule contain a amide group? Cc1cc(C)c(NC(=O)c2cc3ccccc3n2C)c(C)c1 ### Response: Yes
ring_counting
### Instruction: Count the six-membered rings in the following molecule. C[C@]12CC[C@H]3[C@H](CC[C@@]4(O)C[C@@H](O)CC[C@]34CO)[C@@]13CC[C@@H]2[C@@H]1CC(=O)O[C@@H]1O3 ### Response: 4
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CN(CC[NH+](C)C)C(=O)C[C@H]1COCCN1C(=O)c1ccc2[nH]nnc2c1 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC[S@](=O)[C@H]1CCCC[C@@H]1NC(=O)NC1CCC2(CC1)OCCO2 ### Response: 2
functional_group
### Instruction: Does the molecule contain a sulfonyl group? C[C@@]1(NC(=O)c2ccc(Cl)cc2)CCS(=O)(=O)C1 ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [8*]C/C([O-])=N/c1ncn[nH]1 Fragment 2: [9*]n1cnc2c(C)cccc2c1=O ### Response: Cc1cccc2c(=O)n(C/C([O-])=N/c3ncn[nH]3)cnc12
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)c1cc(S(=O)(=O)N[5*])ccc1C Fragment 2: [4*]Cc1ccccc1 ### Response: CC[C@H](C)NC(=O)c1cc(S(=O)(=O)NCc2ccccc2)ccc1C
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C(NNC(=O)c1ccc2c(c1)OCCO2)c1ccoc1 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. n1cccc(c1N[C@H]1CCC[C@@H](C)C1)C#N ### Response: C[C@@H]1CCC[C@H](Nc2ncccc2C#N)C1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CCc1cc(C(=O)N[C@H](C)c2ccccc2)c2c(C3CC3)nn(-c3ccc(F)cc3)c2n1 ### Response: 3
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N([5*])[C@H]1CCSC1 Fragment 2: [4*]C[C@@H]1CCCO1 ### Response: [NH3+]C[C@H]1CC[C@@H](C(=O)N(C[C@@H]2CCCO2)[C@H]2CCSC2)O1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. O=C(CSc1nc2ccccc2o1)Nc1onc2c1CSC2 ### Response: 3
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CCC(=O)N1N=C(c2ccc(Br)cc2)C[C@@H]1c1ccccc1O ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[NH+](C1CCSCC1)[C@H]1CCN(c2ccccc2)C1=O ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@@H](C(=O)N1CCN(c2cccc[nH+]2)CC1)N1CCOC(C)(C)C1 ### Response: 3
ring_counting
### Instruction: Count the six-membered rings in the following molecule. N#Cc1nc(/C=C/c2ccc(F)cc2)oc1N1CCN(C(=O)c2cccc(F)c2)CC1 ### Response: 3
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [16*]c1cccc(F)c1 Fragment 2: [3*]OC(C)(C)C ### Response: CC(C)(C)OC(=O)[C@@H](C(=O)[O-])[C@@H]([NH3+])Cc1cccc(F)c1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [16*]c1c(Cl)cc(Cl)cc1Br Fragment 2: [3*]OCC(=O)NNC([6*])=O ### Response: O=C(COc1c(Cl)cc(Cl)cc1Br)NNC(=O)c1ccc([N+](=O)[O-])cc1
canonicalization
### Instruction: Canonicalize the following SMILES string. C1CN(CC(=O)N2N=C(C[C@@H]2c2cccs2)c2cccs2)CCN1C(=O)COC ### Response: COCC(=O)N1CCN(CC(=O)N2N=C(c3cccs3)C[C@@H]2c2cccs2)CC1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COc1ccccc1N(C)S(=O)(=O)c1cccc2ccccc12 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [16*]c1ccc(F)cc1 Fragment 2: [5*]Nc1cccc(Cl)c1 ### Response: COc1ccc(N2C(=O)CC[C@@H](C(=O)Nc3cccc(Cl)c3)[C@@H]2c2ccc(F)cc2)cc1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1cncc(NC(=O)C2CCN(C(=O)Nc3ccccc3)CC2)c1 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC(C)(C)CNC(=O)NCCc1csc(N2CCCC2)n1 ### Response: 3
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@H]1CN(c2ccc(CNC(=O)CCOc3ccccc3)c[nH+]2)CCO1 ### Response: 3
canonicalization
### Instruction: Canonicalize the following SMILES string. O=C(Nc1c(C)cccc1CC)Cc1c(noc1C)C ### Response: CCc1cccc(C)c1NC(=O)Cc1c(C)noc1C
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CCS(=O)(=O)c1ccc(Cl)cc1C(=O)N(C)CC(F)(F)F ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [14*]c1ccco1 Fragment 2: [13*][C@H]1CCCN1S(=O)(=O)N1CCC(OC)CC1 ### Response: COC1CCN(S(=O)(=O)N2CCC[C@@H]2c2ccco2)CC1
functional_group
### Instruction: Does the molecule contain a sulfonyl group? CS(=O)(=O)[C@@H]1CCC[C@@H]([NH2+]CCc2cccs2)C1 ### Response: Yes
functional_group
### Instruction: Does the molecule contain a halide group? COc1ncc(C(=O)N2CCC(c3cc4n(n3)[C@@H](C(F)(F)F)C[C@@H](C)N4)CC2)cn1 ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]CCn1nc(C)nc1C Fragment 2: [5*]NS(=O)(=O)c1ccccc1 ### Response: Cc1nc(C)n(CCNS(=O)(=O)c2ccccc2)n1
canonicalization
### Instruction: Canonicalize the following SMILES string. N(c1cc(C(=O)Nc2ccc(Cl)cc2)ccc1)S(c1ccc(cc1)OC)(=O)=O ### Response: COc1ccc(S(=O)(=O)Nc2cccc(C(=O)Nc3ccc(Cl)cc3)c2)cc1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CCN1C(=O)c2cccc3c(NC(=O)c4ccn(C)n4)ccc1c23 ### Response: 2
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? CCC(=O)N1CCN(CCc2nc(-c3ccccc3)no2)CC1 ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]Cc1cn2cc(C)ccc2[nH+]1 Fragment 2: [5*]N1CCN([5*])CC1 ### Response: Cc1ccc2[nH+]c(CN3CCN(S(=O)(=O)c4cc(C)sc4C)CC3)cn2c1
functional_group
### Instruction: Does the molecule contain a nitro group? C/C=C/C[C@]1(C(=O)[O-])CCN(C(=O)OC(C)(C)C)C1 ### Response: No
ring_counting
### Instruction: Count the six-membered rings in the following molecule. C[C@@]12CCC(=O)N1[C@@H](C(=O)Nc1nc(-c3ccccc3Cl)cs1)CS2 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C(C1=CCCCO1)N1CCC2(CCCCC2)C1 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. C1CC(CC1)[NH+](CC(N1[C@H]2CCCC[C@H]2OCC1)=O)CC(N)=O ### Response: NC(=O)C[NH+](CC(=O)N1CCO[C@@H]2CCCC[C@@H]21)C1CCCC1
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? COc1cc(NC(=O)c2cccnc2Cl)ccc1-c1cc2ccccc2oc1=O ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)C[8*] Fragment 2: [16*]c1cccc(OC)c1 ### Response: CC[C@@H]1Oc2ccc(NC(=O)Cc3ccc(F)cc3)cc2CN(Cc2cccc(OC)c2)C1=O
functional_group
### Instruction: Does the molecule contain a carboxyl group? CCC/C(C)=C\C(=O)C1CCC(=O)CC1 ### Response: No
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CCCN(CC1CC1)c1cc2c(cc1Cl)[C@@H](N)C(=O)N2 ### Response: 1
functional_group
### Instruction: Does the molecule contain a hydroxyl group? CC[C@H](C)Cn1c(CCCl)nc2c(C)nn(C)c21 ### Response: No
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[NH2+]C(C)(C)C(=O)N[C@H]1CCCCC[C@@H]1C(=O)[O-] ### Response: 3
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C(c1ccc(-c2nc(C3CC3)no2)cc1)N(Cc1cccs1)C1CC1 ### Response: 1
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? Cc1nc(Cc2ccccc2)sc1C(=O)N1CCC[C@@H]1c1ccncc1 ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. c1cccc(n1)[C@@H](C(C)C)NC(Nc1c(ccc(C(=O)NC)c1)OC)=O ### Response: CNC(=O)c1ccc(OC)c(NC(=O)N[C@@H](c2ccccn2)C(C)C)c1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [16*]c1cc(OC)cc(OC)c1 Fragment 2: [15*]C1(O)CCC2(CC1)OCCO2 ### Response: COc1cc(OC)cc(C2(O)CCC3(CC2)OCCO3)c1
canonicalization
### Instruction: Canonicalize the following SMILES string. OCCC[C@@H](C)[NH2+]Cc1c(nn(C)c1Cl)-c1ccccc1 ### Response: C[C@H](CCCO)[NH2+]Cc1c(-c2ccccc2)nn(C)c1Cl
ring_counting
### Instruction: Count the six-membered rings in the following molecule. COC(=O)C(C)(C)C[NH2+][C@@H]1C[C@H]1c1ccccc1 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. C1N(CCC1(C)C)C(=O)CNC(=O)CCc1ccc(C)cc1 ### Response: Cc1ccc(CCC(=O)NCC(=O)N2CCC(C)(C)C2)cc1
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? COC(=O)[C@H](C)CNC(=O)Nc1cccc(SC(F)F)c1 ### Response: Yes
ring_counting
### Instruction: Count the six-membered rings in the following molecule. O=C1O[C@H](/C=N/c2ccc(C(F)(F)F)cc2)c2ccccc21 ### Response: 2
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CCC[NH+](CC)[C@H](C)C(=O)Nc1ccc(F)c(N)c1 ### Response: 1
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? c1ccc(-c2cnc(C[NH2+]C[C@@H]3CCCS3)s2)cc1 ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1ccc(NC(=O)N2CCN(C(=O)[C@H]3CCC(=O)N3)CC2)cc1 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [8*]C[C@@H]1Cc2ccccc2S1 Fragment 2: [8*]Cn1cc(C[NH3+])c(C)n1 ### Response: Cc1nn(C[C@@H]2Cc3ccccc3S2)cc1C[NH3+]
functional_group
### Instruction: Does the molecule contain a ether group? COc1cc2c(cc1OC)CN(C(=O)[C@@H]1CCCN(C(=O)c3cn(C)nc3OC)C1)CC2 ### Response: Yes
functional_group
### Instruction: Does the molecule contain a ketone group? COC(=O)c1ccc(C(=O)Nc2nc3ccc(NC(C)=O)cc3s2)cc1 ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. C1CCCCC1n1nc(C[NH2+]Cc2sccc2C)cc1 ### Response: Cc1ccsc1C[NH2+]Cc1ccn(C2CCCCC2)n1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*][NH+]1CCC[C@@H]1[13*] Fragment 2: [4*]Cc1cccc([16*])c1 ### Response: Cn1cnnc1[C@H]1CCC[NH+]1Cc1cccc(-c2cccnc2)c1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*][C@@H](CC)CO Fragment 2: [8*]CC=C ### Response: C=CCN1C(=O)/C(=C/c2c(N[C@@H](CC)CO)nc3ccccn3c2=O)SC1=S
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1ccc(NC(=O)CCNC(=O)N[C@H]2CC[C@H]([NH+](C)C)C2)c(Cl)c1 ### Response: 3
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@@H]1C[C@@H](C)CN(S(=O)(=O)N2CC[C@H](C(=O)[O-])[C@@H]2C)C1 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]NCc1c(CC)nn(C)c1OC Fragment 2: [4*]Cc1c(CC)nn(C)c1OC ### Response: CCc1nn(C)c(OC)c1CNC(=O)NCC[C@@H]1C[C@H]2CC[C@@H]1C2
canonicalization
### Instruction: Canonicalize the following SMILES string. C1C[NH+]2C[C@H](C)N(c3cc(cc(c3)C)F)C[C@H]2C1 ### Response: Cc1cc(F)cc(N2C[C@H]3CCC[NH+]3C[C@@H]2C)c1
canonicalization
### Instruction: Canonicalize the following SMILES string. N1(CC[C@H](C[C@H]1C)C)C(/C=C/c1ccc(cc1)C(NC)=O)=O ### Response: CNC(=O)c1ccc(/C=C/C(=O)N2CC[C@@H](C)C[C@H]2C)cc1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CC(=O)Nc1ccc(S(=O)(=O)Nc2ccc3c(c2)CCCN3C(=O)c2cccnc2)cc1 ### Response: 4
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? C[C@H](Sc1nc2cc(Cl)ccc2n1Cc1ccccc1)C(=O)N1CCC(C(N)=O)CC1 ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)C[4*] Fragment 2: [5*][NH+](C)[C@@H]1CCCc2ccccc21 ### Response: C[NH+](CC(=O)NC1(C#N)CCCCCC1)[C@@H]1CCCc2ccccc21
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CN1C2=C(C#N)C(=O)CCN2c2ccccc21 ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. C(OC1(Cc2ccccc2)CCCCC1)C([O-])=O ### Response: O=C([O-])COC1(Cc2ccccc2)CCCCC1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. O=c1c2cc(F)ccc2nc([S-])n1CCc1c[nH]c2ccccc12 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. [C@H](C)(Sc1n(c(C2CC2)nn1)Cc1occc1)C(=O)Nc1cccc2c1cccn2 ### Response: C[C@@H](Sc1nnc(C2CC2)n1Cc1ccco1)C(=O)Nc1cccc2ncccc12
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCOc1cccc(C(=O)NC(=S)Nc2ccccc2C#N)c1 ### Response: 2
ring_counting
### Instruction: Count the five-membered rings in the following molecule. O=S(=O)(c1ccccc1)C1[C@@H]2CCC[C@H]1C2Cl ### Response: 0
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [3*]OCC#N Fragment 2: [1*]C(=O)C[8*] ### Response: N#CCOc1cccc(CC(=O)N[C@H]2CCCC[C@@H]2n2cccn2)c1