task
stringclasses
5 values
input
stringlengths
89
339
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCc1cc(C(=O)N[C@@H]2CCCC[C@@H]2C[NH+](C)C)n(C)n1 ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)c1ccc([16*])c([N+](=O)[O-])c1 Fragment 2: [5*]N1CCCC1 ### Response: N#CC1=C(NC(=O)c2ccc(N3CCCC3)c([N+](=O)[O-])c2)S[C@@H]2CCC[C@H]12
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? Cc1c(NC(=O)[C@@H](C)Sc2ncnc3ccccc23)c(=O)n(-c2ccccc2)n1C ### Response: Yes
functional_group
### Instruction: Does the molecule contain a carboxyl group? Cc1ccc(NC(=S)N(Cc2ccccn2)C2CC2)c(C)c1 ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. C(NCc1ccc(-c2nc3ccccc3s2)o1)(=O)c1cnn(C)c1 ### Response: Cn1cc(C(=O)NCc2ccc(-c3nc4ccccc4s3)o2)cn1
canonicalization
### Instruction: Canonicalize the following SMILES string. S(c1cc2[C@H]3C=CC[C@H]3[C@@H](c3cccc(OC)c3)Nc2cc1)(=O)(=O)N(CC)CC ### Response: CCN(CC)S(=O)(=O)c1ccc2c(c1)[C@H]1C=CC[C@H]1[C@@H](c1cccc(OC)c1)N2
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? CCC1(C(=O)Nc2ccc(C)c(S(N)(=O)=O)c2)CCCC1 ### Response: Yes
ring_counting
### Instruction: Count the six-membered rings in the following molecule. OCC1CCN([C@@H]2CCC[NH+](Cc3cccnc3)C2)CC1 ### Response: 3
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [16*]c1cccnc1 Fragment 2: [8*]C[C@H]([8*])[NH2+]C ### Response: C[NH2+][C@H](Cc1cccnc1)[C@H]1CCO[C@]2(CCOC2)C1
functional_group
### Instruction: Does the molecule contain a phenol group? O=C(CN1N=C(c2ccc(Cl)cc2)CCC1=O)NCc1cccs1 ### Response: No
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Cc1ccc(CCN2C[C@]34C=C[C@H](O3)[C@H](C(=O)N3CC(O)C3)[C@H]4C2=O)cc1 ### Response: 3
ring_counting
### Instruction: Count the five-membered rings in the following molecule. C[C@@H]1CN(Cc2noc(-c3ccc(F)cc3)n2)CC[C@@H]1[NH3+] ### Response: 1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. O=C(c1ncccc1F)N1C[C@H](CO)[C@H](C[NH+]2CCCCC2)C1 ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. c1cc(ccc1F)CNC(=O)CSc1nc2C[C@@H](C)Sc2c(=O)n1Cc1ccccc1 ### Response: C[C@@H]1Cc2nc(SCC(=O)NCc3ccc(F)cc3)n(Cc3ccccc3)c(=O)c2S1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. O=C(/N=C1\S[C@@H]2CS(=O)(=O)C[C@@H]2N1c1ccc(Cl)c(Cl)c1)C1CC1 ### Response: 1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. COC(=O)[C@@H]1C[C@H]1C(=O)NNc1cc(C#N)cc(Cl)n1 ### Response: 0
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC(C)(O)CCc1ccc(C[NH+]2CCC(c3ccncc3)CC2)cc1 ### Response: 4
canonicalization
### Instruction: Canonicalize the following SMILES string. C(NC(=O)[C@@H](S(=O)(=O)Cc1nc(c(s1)C)C)C)C(F)(F)F ### Response: Cc1nc(CS(=O)(=O)[C@@H](C)C(=O)NCC(F)(F)F)sc1C
ring_counting
### Instruction: Count the five-membered rings in the following molecule. C[C@@H](CCl)C[NH+](C)[C@@H](C)Cc1cccs1 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [3*]O[C@@H]1CCN([5*])C1 Fragment 2: [5*]NCC ### Response: CCNC(=O)NC1(C(=O)N2CC[C@@H](OCCC(C)C)C2)CCCC1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)C(=O)C[8*] Fragment 2: [14*]c1nc2ccccc2s1 ### Response: CC(C)c1ccccc1NC(=O)C(=O)Cc1nc2ccccc2s1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)c1cc(S(=O)(=O)NC)oc1C Fragment 2: [5*]N1CCO[C@@H](C)C1 ### Response: CNS(=O)(=O)c1cc(C(=O)N2CCO[C@@H](C)C2)c(C)o1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COc1cccc2c1OCC(C[NH+]1CC[C@]3(CCCN(C)C3=O)C1)=C2 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N1CC[NH+](C)CC1 Fragment 2: [5*]N[C@H]1COC[C@@H]1[15*] ### Response: Cc1cc(C(=O)N[C@H]2COC[C@@H]2N2CC[NH+](C)CC2)c2cccc(C)c2n1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. O=C1O[C@H](C(=O)Nc2ccnc3ccnn23)Cc2ccccc21 ### Response: 3
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)C[8*] Fragment 2: [9*]n1nnc([14*])n1 ### Response: N#CCN(C(=O)Cn1nnc(-c2ccc(Cl)cc2)n1)C1CCCC1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)CN[5*] Fragment 2: [1*]C(=O)c1cc(C)oc1C ### Response: CO[C@]1(C)C[C@@H](N(C)C(=O)CNC(=O)c2cc(C)oc2C)C1(C)C
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1ccc(CNC(=O)CSc2ccc(-c3cccs3)nn2)cc1 ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1cc(C)n(C[C@H]2CCCN2c2ccc(C#N)cn2)n1 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. N(C[C@@H]1CCCO1)C(c1cc(OCc2ccccc2)ccc1)=O ### Response: O=C(NC[C@@H]1CCCO1)c1cccc(OCc2ccccc2)c1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. O=C(CCn1cnc2ccccc2c1=O)Nc1ccc(S(=O)(=O)N2CCCC2)cc1 ### Response: 1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CCOc1cc(NC(=O)[C@@H]2C=C[C@H]([NH3+])C2)ccc1OC ### Response: 1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CC(=O)Nc1ccc(C2=NN(C(C)=O)[C@@H](c3cccs3)C2)cc1 ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C(CNC(=O)c1ccc(Oc2nccs2)cc1)NC1CC1 ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [3*]OCc1nc(C)no1 Fragment 2: [5*]Nc1cccc(C#Cc2ccccc2)c1 ### Response: Cc1noc(COCC(=O)Nc2cccc(C#Cc3ccccc3)c2)n1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1cnn(CCCNC(=O)N[C@@H]2CCCN(c3ccccc3F)C2=O)c1 ### Response: 3
ring_counting
### Instruction: Count the five-membered rings in the following molecule. COc1cc(NS(=O)(=O)c2ccc(N3C(=O)[C@@H]4[C@@H](C3=O)[C@H]3C=C[C@@H]4C3)cc2)nc(OC)n1 ### Response: 3
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CCC[NH+]1CCC(N(CC2CC[NH2+]CC2)C(C)C)CC1 ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. c1c(NC(C2CCCC2)=O)n(C)nc1C(=O)NCc1n(Cc2ccccc2)c2ccccc2n1 ### Response: Cn1nc(C(=O)NCc2nc3ccccc3n2Cc2ccccc2)cc1NC(=O)C1CCCC1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. O[C@@H](c1cccc(Cl)c1F)[C@H]1CCOC2(CCC2)C1 ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. [C@](CC)([C@H](O)COC(C)C)(N1CCOCC1)C ### Response: CC[C@](C)([C@H](O)COC(C)C)N1CCOCC1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCn1ncc(C(=O)N[C@@H]2CC[C@H](SC)C2)c1C(F)(F)F ### Response: 2
ring_counting
### Instruction: Count the five-membered rings in the following molecule. C[C@H](CCc1ccccc1F)[NH2+]CCc1nc2cc(F)ccc2n1C ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COc1ccc2cc(CNc3ncc(C(N)=O)cc3Cl)ccc2c1 ### Response: 1
functional_group
### Instruction: Does the molecule contain a ketone group? Cc1nnc(S[C@@H](C)C(=O)Nc2ccccc2Sc2ccccc2)n1N ### Response: No
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [16*]c1cccnc1 Fragment 2: [9*]n1c(C)c(C)c2c1ncn1nc([14*])nc21 ### Response: Cc1c(C)n(-c2cccnc2)c2ncn3nc(-c4ccccc4Br)nc3c12
functional_group
### Instruction: Does the molecule contain a amide group? CC(C)C[NH+]1CC[C@H](N2CCOCC2)C[C@H]1C ### Response: No
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CN(C)C(=O)CC[NH2+]Cc1cnc2cnc(Br)cn12 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. C(c1sccc1)NC(c1nn2c(C(F)(Cl)F)cc(nc2c1)-c1cccs1)=O ### Response: O=C(NCc1cccs1)c1cc2nc(-c3cccs3)cc(C(F)(F)Cl)n2n1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Cn1cc(S(=O)(=O)N2CCN(C(=O)c3ccccc3O)CC2)cc1C(N)=O ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[NH+](C)Cc1cc(NC(=O)[C@@H]2CO[C@H]3C=CC=C[C@@H]3O2)[nH]n1 ### Response: 1
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? Cc1cccc(-c2nnc(NC(=O)c3ccc(S(=O)(=O)N4CCC[C@H](C)C4)cc3)o2)c1 ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]C[C@H]([4*])C Fragment 2: [5*]Nc1ccc([N+](=O)[O-])cc1 ### Response: C[C@H](CNc1ccc([N+](=O)[O-])cc1)NS(=O)(=O)c1ccc2ccccc2c1
canonicalization
### Instruction: Canonicalize the following SMILES string. C1[NH+](CCC(O)C1)Cc1onc(C(=O)N[C@H](C)c2ccc(C)nc2)c1 ### Response: Cc1ccc([C@@H](C)NC(=O)c2cc(C[NH+]3CCC(O)CC3)on2)cn1
functional_group
### Instruction: Does the molecule contain a amide group? CC(C)C(=O)NCCNC(=O)c1cc(Br)ccc1Cl ### Response: Yes
functional_group
### Instruction: Does the molecule contain a halide group? C=CCOc1c(OC)cccc1[C@@H]1CC(=O)Nc2c(-c3ccccc3)csc21 ### Response: No
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CC[C@@](C)(O)c1cc(Br)ccc1F ### Response: 0
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC(=O)Nc1c(C)cc(NC(=O)N[C@@H](C)[C@H](C)CO)cc1C ### Response: 4
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CCOC(=O)[C@H](/C(C)=N/NC(=O)OC)C(C)C ### Response: 0
ring_counting
### Instruction: Count the six-membered rings in the following molecule. C[C@H](NC(=O)c1cc(C2CC2)on1)c1ccc2c(c1)OCCO2 ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N(C)C[8*] Fragment 2: [5*]N[C@@H](C)C[8*] ### Response: Cc1cc(CN(C)C(=O)N[C@@H](C)Cc2ccc3ccccc3c2)no1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CSC(C)(C)C[NH2+][C@H](C)Cn1cnc(C)c1C ### Response: 3
functional_group
### Instruction: Does the molecule contain a phenol group? Cc1ccc(NC(=S)N(Cc2ccc3c(c2)OCO3)Cc2cc3ccc(C)cc3[nH]c2=O)cc1 ### Response: No
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CC[C@H](Cc1ccccc1)[NH2+]Cc1nncn1C1CC1 ### Response: 1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Cn1cnc([N+](=O)[O-])c1S(=O)(=O)NCCc1ccccc1F ### Response: 1
functional_group
### Instruction: Does the molecule contain a ether group? CCCc1sc(C(=O)O[C@H](C)C(N)=O)cc1CC ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. Cc1nc(ccc1)NC(=O)c1c(C)noc1C ### Response: Cc1cccc(NC(=O)c2c(C)noc2C)n1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C=CCSc1nc2ccccc2n1CC(=O)NC(N)=O ### Response: 3
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[NH+](C)C1CCN(C[C@@H]2[C@H](O)C(C)(C)OC2(C)C)CC1 ### Response: 1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. c1ccc2c(c1)C[C@H](C[NH2+]C(C1CC1)C1CC1)S2 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. N(/C(=[NH+]/C)N1CCC(OCC)CC1)CCc1nc2ccccc2[nH]1 ### Response: CCOC1CCN(/C(NCCc2nc3ccccc3[nH]2)=[NH+]\C)CC1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. C[C@@H](C(=O)Nc1ccc(Cl)cc1)n1nc(-c2ccccc2)c2c(c1=O)CCCC2 ### Response: 4
functional_group
### Instruction: Does the molecule contain a amide group? O=C1C[NH+](CCn2c(=O)oc3cccnc32)CCN1 ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]Nc1ccc2c(c1)OCO2 Fragment 2: [12*]S(=O)(=O)c1ccc(C)cc1C ### Response: Cc1ccc(S(=O)(=O)N2CCC(C(=O)O[C@@H](C)C(=O)Nc3ccc4c(c3)OCO4)CC2)c(C)c1
canonicalization
### Instruction: Canonicalize the following SMILES string. C(=O)(N(Cc1cnccc1)C[C@H]1OCCC1)N[C@H](c1sccc1)C(C)(C)C ### Response: CC(C)(C)[C@H](NC(=O)N(Cc1cccnc1)C[C@@H]1CCCO1)c1cccs1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]Nc1ccc2c(c1)OCO2 Fragment 2: [4*]CCO ### Response: CCN(CCO)c1ncnc(Nc2ccc3c(c2)OCO3)c1N
functional_group
### Instruction: Does the molecule contain a ketone group? C[C@@H]1C(C(=O)CSc2n[nH]c(-c3ccccc3)n2)=C[C@H](C)[NH+]1Cc1ccco1 ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. C1(=O)N(c2ccc(cc2)C)C[C@@H](C1)C(NCC[NH+]1CCC(CC1)c1cccs1)=O ### Response: Cc1ccc(N2C[C@H](C(=O)NCC[NH+]3CCC(c4cccs4)CC3)CC2=O)cc1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [14*]c1nc([14*])c(C)o1 Fragment 2: [4*]Cc1nc([14*])oc1C ### Response: COc1ccc(-c2nc(C[NH+](C)[C@H](C)c3nc(C)cs3)c(C)o2)c(OC)c1C
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N([5*])CC Fragment 2: [15*]C1CCC([NH3+])CC1 ### Response: CCN(C(=O)c1cc(Cl)ccc1O)C1CCC([NH3+])CC1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [8*]C(F)F Fragment 2: [1*]C(=O)c1ccsc1 ### Response: O=C(Nc1ccc2[nH]c(C(F)F)nc2c1)c1ccsc1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)c1oc2c(c1C)/C(=N/NC([6*])=O)CCC2 Fragment 2: [5*]Nc1cc(C)ccn1 ### Response: Cc1ccnc(NC(=O)c2oc3c(c2C)/C(=N/NC(=O)c2ccc([N+](=O)[O-])cc2)CCC3)c1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)[C@@H]([8*])C Fragment 2: [16*]c1ccc(Cl)c(Cl)c1 ### Response: C[C@@H](C(=O)NC[C@@H]1CCCO1)c1ccc(Cl)c(Cl)c1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Cc1nn(CN2CCN(c3cccc(Cl)c3)CC2)c(=S)n1Cc1ccccc1 ### Response: 3
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Cc1cc(C(=O)N2CCC[C@@H]2c2ccc[nH]2)c(C)s1 ### Response: 3
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CCNC(=O)[C@@H](C)Sc1ccc(NC(C)=O)cc1 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. C(N[C@H](C)C(=O)Nc1cccc(C(Nc2cc(ccc2)F)=O)c1)(C)=O ### Response: CC(=O)N[C@H](C)C(=O)Nc1cccc(C(=O)Nc2cccc(F)c2)c1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Cn1c(NC(=O)CSCc2ccccc2)cc(=O)n(C)c1=O ### Response: 0
functional_group
### Instruction: Does the molecule contain a ether group? O=C(c1ccc(OCC(F)F)nc1)N1CC[NH+](C2CCCCC2)CC1 ### Response: Yes
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CCC[NH2+][C@@H]1CC[C@@H](N2CCC[C@H](C(F)(F)F)C2)C1 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1cc(C(=O)Nc2ccc(C[NH+]3CCCC3)cc2)c2cnn(Cc3cccs3)c2n1 ### Response: 1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Cc1ccc(C(=O)[O-])cc1NC(=O)c1nn(C)c(=O)c2ccccc12 ### Response: 3
canonicalization
### Instruction: Canonicalize the following SMILES string. c12c(ccs1)cc(cc2)C(NC1(C(N)=O)CCCC1)=O ### Response: NC(=O)C1(NC(=O)c2ccc3sccc3c2)CCCC1
canonicalization
### Instruction: Canonicalize the following SMILES string. O(C)c1cccn(c1=O)Cc1nc(C2CCCC2)on1 ### Response: COc1cccn(Cc2noc(C3CCCC3)n2)c1=O
canonicalization
### Instruction: Canonicalize the following SMILES string. c1cc2ccc(nc2cc1)-c1cccc(NS(=O)(c2cc(ccc2OC)OC)=O)c1 ### Response: COc1ccc(OC)c(S(=O)(=O)Nc2cccc(-c3ccc4ccccc4n3)c2)c1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COc1cc(OC)c(NC(=O)[C@H](C)c2ccc(Cl)s2)cc1F ### Response: 3
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Cc1nn(CCO)c(C)c1C[NH+]1CCC(CC[NH+](C)C)CC1 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1cc(F)cc([C@H](O)c2c(F)cccc2F)c1 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C(CNc1ccccc1)Nc1cccc(OCc2ccccc2)c1 ### Response: 2
functional_group
### Instruction: Does the molecule contain a sulfonyl group? CCC1(CC)[C@H]([NH2+]C2CCN(c3nc(C)cs3)CC2)C[C@H]1OC ### Response: No