task
stringclasses
5 values
input
stringlengths
89
339
ring_counting
### Instruction: Count the five-membered rings in the following molecule. C=C(C)[C@H](CC(F)(F)F)[NH2+]CC ### Response: 0
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? FC(F)(F)c1cccc2c1CCCC2 ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [14*]c1cn2c(=O)cc(C)[nH]c2n1 Fragment 2: [16*]c1ccc(Cl)cc1 ### Response: Cc1cc(=O)n2cc(-c3ccc(Cl)cc3)nc2[nH]1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)c1ccc(C)c(Br)c1 Fragment 2: [5*]Nc1ccc(S(=O)(=O)N[5*])cc1 ### Response: CC[C@@H](C)NS(=O)(=O)c1ccc(NC(=O)c2ccc(C)c(Br)c2)cc1
functional_group
### Instruction: Does the molecule contain a amide group? CCCCC[C@@H](C)Nc1ccc(C(=O)N(C)C)cn1 ### Response: Yes
functional_group
### Instruction: Does the molecule contain a amide group? Cc1cccc(CN(C(=O)[C@@H](C)NC(=O)OC(C)(C)C)C2CC2)c1 ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCc1ccc(-c2ccc(N3CCC(C(=O)[O-])CC3)nn2)cc1 ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. c1c2c(nc(NC(=O)c3ccc(o3)C)s2)ccc1C ### Response: Cc1ccc2nc(NC(=O)c3ccc(C)o3)sc2c1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCN1C[C@H](CN(C)Cc2[nH+]cc(C)c(OC)c2C)Oc2ccccc21 ### Response: 2
functional_group
### Instruction: Does the molecule contain a aldehyde group? COc1cc([C@H]2C(C(=O)Nc3ccccn3)=C(C)NC3=C2C(=O)CCC3)ccc1OCc1ccccc1 ### Response: No
functional_group
### Instruction: Does the molecule contain a nitro group? COc1cccc(N2C[C@H](C(=O)Nc3nc4c(s3)COCC4)CC2=O)c1 ### Response: No
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CN(C[C@H](O)c1c(F)cccc1F)c1ccccc1 ### Response: 2
ring_counting
### Instruction: Count the five-membered rings in the following molecule. C[C@@H]([NH2+]CCOc1ccccc1Cl)c1cccc(N2CCOC2=O)c1 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]NCc1cccnc1[14*] Fragment 2: [3*]OCC ### Response: CCOc1ncccc1CNC(=O)c1ccc(Cl)c(S(C)(=O)=O)c1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]Cc1cccnc1[14*] Fragment 2: [5*]N([5*])C(C)C ### Response: CC(C)Oc1ncccc1CNC(=O)N(C[C@@H]1C[C@@H]1C)C(C)C
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(OC)c(O)c(ccc1)CNC(N[C@@H]1[C@@H](C1)CCC)=O ### Response: CCC[C@@H]1C[C@@H]1NC(=O)NCc1cccc(OC)c1O
functional_group
### Instruction: Does the molecule contain a ether group? CCOc1ccc(-n2c3nc4ccccc4nc3c3c(=O)n(C[C@@H]4CCCO4)c(CC)nc32)cc1 ### Response: Yes
functional_group
### Instruction: Does the molecule contain a nitro group? CCC[C@]1(C(=O)[O-])CCN(c2cncc(C(=O)OC)n2)C1 ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. N1(c2ccc(cc2)F)CC[NH+](CC1)C[C@H](O)COc1ccc(cc1)Cl ### Response: O[C@H](COc1ccc(Cl)cc1)C[NH+]1CCN(c2ccc(F)cc2)CC1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [16*]c1ccc(F)cc1Cl Fragment 2: [16*]c1ccc(C)cc1 ### Response: Cc1ccc(C(CO)(CO)Cc2ccc(F)cc2Cl)cc1
functional_group
### Instruction: Does the molecule contain a ether group? COC(=O)c1c(C)[nH]c(C(=O)N[C@H](C)c2cc(C)ccc2OC)c1C ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [9*]n1cc[nH+]c1 Fragment 2: [5*]N1CCC[C@H]([15*])C1 ### Response: Cn1nnc2cc(C(=O)N3CCC[C@H](n4cc[nH+]c4)C3)ccc21
canonicalization
### Instruction: Canonicalize the following SMILES string. S([C@H]1C[C@]([NH2+]C2CC2)(CCC1)C(=O)[O-])c1ncn[nH]1 ### Response: O=C([O-])[C@@]1([NH2+]C2CC2)CCC[C@@H](Sc2ncn[nH]2)C1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(CCc2scc(C[NH+]3CCC[C@@H]3C(=O)N(C)C)n2)ccccc1 ### Response: CN(C)C(=O)[C@H]1CCC[NH+]1Cc1csc(CCc2ccccc2)n1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N[C@H]1CCCCC[C@H]1[15*] Fragment 2: [1*]C(=O)c1cc(C)nc2c1cnn2[9*] ### Response: COC(=O)[C@@H]1CCCCC[C@@H]1NC(=O)c1cc(C)nc2c1cnn2C(C)C
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*][NH2+]Cc1scnc1C Fragment 2: [4*]Cc1scnc1C ### Response: CCn1c(C)cc(C[NH2+]Cc2scnc2C)c1C
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]NC(=S)N1CCOCC1 Fragment 2: [16*]c1ccccc1F ### Response: Fc1ccccc1NC(=S)N1CCOCC1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. COCCN1C[C@]2(CCC[NH+](Cc3ccc(SC)cc3)C2)CCC1=O ### Response: 0
ring_counting
### Instruction: Count the five-membered rings in the following molecule. COc1ccccc1NC(=O)C1CC[NH+](CCc2ccc([N+](=O)[O-])cc2)CC1 ### Response: 0
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N(CC)CC Fragment 2: [16*]c1ccc2c(c1)OCCCO2 ### Response: CCN(CC)S(=O)(=O)c1ccc(Nc2ccc3c(c2)OCCCO3)c([N+](=O)[O-])c1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CCOCCC(=O)Nc1c(C)cnn1[C@@H]1CCCc2ccccc21 ### Response: 1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Cc1cc(Br)ccc1COC(=O)CCc1nc(C2CC2)no1 ### Response: 1
functional_group
### Instruction: Does the molecule contain a amide group? CN(C)C(=O)Cn1cc(NC(=O)C(=O)NCCC2=CCCCC2)cn1 ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCCn1ncnc1C[C@H](O)[C@@H]1C[NH+](C)CCN1C ### Response: 3
ring_counting
### Instruction: Count the five-membered rings in the following molecule. C[C@H](NC(=O)N1CC[C@](O)(C(F)(F)F)C1)c1ccc2c(c1)OCO2 ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(ccc(cc1)OC(C)C)[C@@H]([NH2+][C@@H](c1ccc(Cl)cc1)CO)C ### Response: CC(C)Oc1ccc([C@H](C)[NH2+][C@H](CO)c2ccc(Cl)cc2)cc1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)c1ccc(O[3*])nc1 Fragment 2: [3*]OCC(F)F ### Response: N#Cc1ccc(N(C(=O)c2ccc(OCC(F)F)nc2)C2CC2)cc1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cn1c(SCC(=O)Nc2cc(=O)n(C)c(=O)n2C)nnc1-c1ccccc1Br ### Response: 2
ring_counting
### Instruction: Count the five-membered rings in the following molecule. C=C1CCCC(C)(C)[C@]12CC=C(C)CC2 ### Response: 0
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? CC1=NN(C(=S)Cc2ccccc2)[C@@](C)(O)C1 ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. N(=C\c1cc(Br)ccc1O)/NC(=O)[C@H]1N=NC(=C1)c1ccccc1 ### Response: O=C(N/N=C/c1cc(Br)ccc1O)[C@@H]1C=C(c2ccccc2)N=N1
functional_group
### Instruction: Does the molecule contain a amine group? Cc1ccc(/N=C2/COCCN2)cc1 ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CN(C)c1ncccc1N(C)C(=O)[C@H]1C[C@H]1c1cccc(Cl)c1Cl ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)C1(S(=O)(=O)c2cc(C)ccc2C)CCCC1 Fragment 2: [8*]Cc1ccccc1 ### Response: Cc1ccc(C)c(S(=O)(=O)C2(C(=O)Nc3nnc(Cc4ccccc4)s3)CCCC2)c1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COC[C@@H](O)c1ccc(Br)cc1 ### Response: 2
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Nc1nnc(SCC(=O)N2CC[NH+](C34CC5CC(CC(C5)C3)C4)CC2)s1 ### Response: 1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. O=S(=O)(NCc1ccccc1)N[C@@H]1CCc2cccnc21 ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [3*]Oc1ccc(N[5*])cc1C#N Fragment 2: [3*]Oc1ccc([16*])cc1C#N ### Response: C[C@H](CO)NC(=O)Nc1ccc(OCC(F)(F)F)c(C#N)c1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N1CCOCC1 Fragment 2: [4*]CCC[8*] ### Response: COc1ccc([C@H]2c3c(oc4ccccc4c3=O)C(=O)N2CCCN2CCOCC2)cc1OC
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1oc2cc(OCC(=O)[O-])ccc2c(=O)c1Oc1ccc(Cl)cc1Cl ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. O(c1ccc(C(NC[C@H]2C(N=C(C=C2C)C)=O)=O)c(F)c1)C ### Response: COc1ccc(C(=O)NC[C@H]2C(=O)N=C(C)C=C2C)c(F)c1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@H](C(=O)Nc1nc2ccccc2s1)n1c(N)nnc1SCCc1ccccc1 ### Response: 3
canonicalization
### Instruction: Canonicalize the following SMILES string. Cc1nc(cs1)COc1cccc(c1)C(N1S(=O)(CCC1)=O)=O ### Response: Cc1nc(COc2cccc(C(=O)N3CCCS3(=O)=O)c2)cs1
functional_group
### Instruction: Does the molecule contain a sulfonyl group? C[C@]12C[C@H](NC(=S)N1c1ccc(Br)cc1)c1cc([N+](=O)[O-])ccc1O2 ### Response: No
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Cc1ccccc1-c1cccc(CN2CCn3c(nnc3C(F)(F)F)C2)c1 ### Response: 3
functional_group
### Instruction: Does the molecule contain a ketone group? CCN[C@@]1(C#N)CC[C@@H](n2nc(C)c(CC)c2C)C1 ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(C(=O)Nc2cc(C(NCC)=O)c3ccccc3n2)c(nn(CC)c1Cl)C ### Response: CCNC(=O)c1cc(NC(=O)c2c(C)nn(CC)c2Cl)nc2ccccc12
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COc1ccc(N[C@@H]2C[C@@H](C)Nc3cc(OC)c(OC)cc32)cc1OC ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1ccccc1CCC(=O)N1CCC(Cn2cc([C@H](C)O)nn2)CC1 ### Response: 3
canonicalization
### Instruction: Canonicalize the following SMILES string. [C@@H](Cc1ccc(cc1)OC)(c1[nH]c2ccccc2n1)/C(N)=N/O ### Response: COc1ccc(C[C@@H](/C(N)=N/O)c2nc3ccccc3[nH]2)cc1
functional_group
### Instruction: Does the molecule contain a sulfonyl group? Cc1ccc([C@@H](C)NC(=O)[C@@H]2CC(=O)N(c3ccc(C)cc3)C2)cc1 ### Response: No
functional_group
### Instruction: Does the molecule contain a ester group? Cc1ccc([C@H](C)NC(=O)c2ccc(Cl)cc2N)cc1F ### Response: No
functional_group
### Instruction: Does the molecule contain a thiol group? COc1ccc(CC(=O)Nc2nnc(-c3ccccc3OC)o2)cc1C ### Response: No
functional_group
### Instruction: Does the molecule contain a carboxyl group? CCOC(=O)NC(=O)c1c(NC(=O)Cc2ccc(F)cc2)sc2c1CC[C@H](C)C2 ### Response: No
ring_counting
### Instruction: Count the six-membered rings in the following molecule. C[C@H]1OCC[C@H]1C(=O)N1CCN(CC(=O)N2CCCCCC2)CC1 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [16*]c1ccccc1OC Fragment 2: [3*]OCc1cc([14*])no1 ### Response: COc1ccccc1-c1cc(COC(=O)[C@@H]2Oc3ccccc3O[C@@H]2C)on1
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? O=C([O-])c1cc(/C=C/c2cccc3ccccc23)ncn1 ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Nc1nnc(CCNC(=O)C2CCN(C(=O)[C@@H]3CC(=O)N(c4ccccc4)C3)CC2)s1 ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCCn1nc(-c2ccc(C)s2)ccc1=O ### Response: 3
canonicalization
### Instruction: Canonicalize the following SMILES string. C(C)[C@@H]1[C@H](CCCC1)[NH2+]Cc1ccc(c(OCC)c1)O ### Response: CCOc1cc(C[NH2+][C@H]2CCCC[C@@H]2CC)ccc1O
functional_group
### Instruction: Does the molecule contain a ether group? COC(=O)c1ccc(CN2C(=O)N[C@H](Cc3ccccc3)C2=O)o1 ### Response: Yes
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CN(Cc1nc(-c2cccnc2)no1)C(=O)c1cc(=O)[nH]c([O-])n1 ### Response: 2
functional_group
### Instruction: Does the molecule contain a ether group? COCC[C@@H](C)C(=O)N[C@H]1CCN(c2ccccc2)C1=O ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N1CCO[C@@H](C)[C@@H]1C Fragment 2: [5*]NCc1c(CC)nn(C)c1OC ### Response: CCc1nn(C)c(OC)c1CNC(=O)N1CCO[C@@H](C)[C@@H]1C
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*][C@H]([8*])CN[5*] Fragment 2: [14*]c1ccco1 ### Response: CC[NH+](CC)[C@@H](CNC(=O)N1CCN(c2ncccn2)CC1)c1ccco1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. O=C(Nc1ccccn1)c1cc(=O)c(OCc2cccc(Cl)c2)c[nH]1 ### Response: 3
canonicalization
### Instruction: Canonicalize the following SMILES string. C(NC(c1cccc(c1C)C)=O)C(OC1CCCCC1)=O ### Response: Cc1cccc(C(=O)NCC(=O)OC2CCCCC2)c1C
functional_group
### Instruction: Does the molecule contain a halide group? CCN(C[C@@H]1CCCO1)C(=O)Nc1ccc(F)c(C(=O)N(C)C)c1 ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C(CCc1c[nH]c2ccccc12)Nn1cnc2c(cnn2-c2ccccc2)c1=O ### Response: 3
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Cc1ccc2nc(-c3cccnc3)cc(C(=O)NCC[NH+]3CCN(c4ccccc4F)CC3)c2c1 ### Response: 0
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)c1cc(OC)cc(OC)c1 Fragment 2: [16*]c1cccc([N+](=O)[O-])c1 ### Response: COc1cc(OC)cc(C(=O)NC(=S)Nc2cccc([N+](=O)[O-])c2)c1
functional_group
### Instruction: Does the molecule contain a amine group? O=C1CC[C@H](C(=O)N(CC(F)(F)F)C2CCOCC2)N1 ### Response: No
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [6*]C(N)=O Fragment 2: [1*]C(=O)C[4*] ### Response: C[C@@H](NC(=O)CNc1ccccc1C(N)=O)c1ccc(F)cc1F
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [8*]C[C@H]1CCCN1S(=O)(=O)N1CCOCC1 Fragment 2: [13*][C@H]1CCCN1S(=O)(=O)N1CCOCC1 ### Response: O=S(=O)(N1CCOCC1)N1CCC[C@@H]1Cn1ccnc1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C(CSC1CCCC1)Nc1cccc2ncccc12 ### Response: 2
functional_group
### Instruction: Does the molecule contain a ether group? CCC[NH2+][C@@H]1CCC[C@H]1CC[NH+](C)C1CCOCC1 ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]NC(N[5*])=[NH+]C Fragment 2: [4*]Cc1cccc(C)c1 ### Response: C/[NH+]=C(\NCc1cccc(C)c1)NCc1ccc(C)s1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [3*]OC(F)(F)F Fragment 2: [1*]C(=O)[C@@H]1C[C@H]1[15*] ### Response: COC(=O)[C@H](C)NC(=O)[C@@H]1C[C@H]1c1ccccc1OC(F)(F)F
canonicalization
### Instruction: Canonicalize the following SMILES string. C1N(C[C@H](CC1)C(NCc1ccccc1F)=O)c1sc2nc(cc(n2n1)=O)C ### Response: Cc1cc(=O)n2nc(N3CCC[C@H](C(=O)NCc4ccccc4F)C3)sc2n1
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? Cc1nn(C)c(C)c1OS(=O)(=O)c1cccc(Br)c1 ### Response: Yes
functional_group
### Instruction: Does the molecule contain a amide group? CN(C)C(=O)C[NH+](C)Cc1nc2c(N)cccc2o1 ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N1CCNC(=O)[C@H]1[13*] Fragment 2: [4*]Cc1cc(F)c(F)cc1F ### Response: O=C1NCCN(Cc2cc(F)c(F)cc2F)[C@@H]1c1ccccc1
functional_group
### Instruction: Does the molecule contain a hydroxyl group? O=C1CC2(CCC2)NC(=O)N1C1CCCC1 ### Response: No
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Cc1ccc(-n2[nH]c(C(=O)N[C@@H](C)c3ccc(Cl)s3)cc2=O)cc1 ### Response: 2
functional_group
### Instruction: Does the molecule contain a ketone group? CCOc1ccc(-c2[nH+]ccn2CCc2ccncc2)cc1CO ### Response: No
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C([O-])C[C@H](Cc1ccc(Cl)cc1)C(=O)Nc1cc(Cl)ccc1Cl ### Response: 4
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [8*]C(C)(C)C Fragment 2: [4*]Cc1sc(C)nc1C ### Response: Cc1nc(C)c(C[NH2+]Cc2nc(C(C)(C)C)cs2)s1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]CC(N)=O Fragment 2: [11*]Sc1nc2ccccc2cc1C#N ### Response: N#Cc1cc2ccccc2nc1SCC(N)=O
canonicalization
### Instruction: Canonicalize the following SMILES string. Clc1ccc([C@@H]2[C@H](C(Nc3cccc(c3C(=O)N)C)=O)C2)cc1Cl ### Response: Cc1cccc(NC(=O)[C@@H]2C[C@@H]2c2ccc(Cl)c(Cl)c2)c1C(N)=O
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C#CCOc1ccc(C[NH2+]CCc2ccc(F)cc2)cc1 ### Response: 3