task
stringclasses
5 values
input
stringlengths
89
339
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CNC(=O)c1ccccc1NC(=O)c1ccc(SCc2cccnc2)cc1 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1c(Sc2ncccn2)cc(C)c(NC(=O)N(C)C2CC2)c1 ### Response: Cc1cc(Sc2ncccn2)ccc1NC(=O)N(C)C1CC1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Cn1ccnc1C(=O)c1ccc(NC(=O)[C@H]2C[C@@H]2c2ccccc2F)cc1 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1nnc(CN(C)Cc2cc(Cl)ccc2F)n1C ### Response: 1
functional_group
### Instruction: Does the molecule contain a sulfonyl group? O=C(/C=C/[C@H]1CC=CCC1)Oc1ccc(/C=C2/SC(=S)N([C@H]3CCS(=O)(=O)C3)C2=O)cc1 ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N1CCc2sccc2[C@H]1CC Fragment 2: [1*]C(=O)C[8*] ### Response: CC[C@@H]1c2ccsc2CCN1C(=O)Cn1ccc(=O)c2sccc21
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? FC(F)(F)c1cccc2c1CCCC2 ### Response: 1
functional_group
### Instruction: Does the molecule contain a amine group? O=C(Cc1cnn(-c2ccccc2)c1)N1CCC[C@H]1c1cccc(Br)c1 ### Response: No
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C(/C=C/C1CC1)NCCC[NH+]1CCN(c2ccccc2Cl)CC1 ### Response: 3
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [16*]c1c(F)cccc1OC Fragment 2: [1*]C(=O)NCC[4*] ### Response: COc1cccc(F)c1[C@H](C)NC(=O)NCC[NH+]1CCC(OC)CC1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@@H](CCN1CCOCC1)NC(=O)[C@H]1CN(C)CCO1 ### Response: 4
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)c1cnn([9*])c1C Fragment 2: [1*]C(=O)CN([5*])C ### Response: Cc1c(C(=O)N(C)CC(=O)OC(C)(C)C)cnn1-c1ccc(Br)cc1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [3*]OCC Fragment 2: [1*]C(=O)[C@]1([NH2+][5*])CCC[C@@H](S[11*])C1 ### Response: CCOC(=O)[C@]1([NH2+]C(C)C)CCC[C@@H](SC(C)C)C1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1nc(C(C)(C)c2ccccc2)sc1C(=O)Nc1ccnn1C(C)C ### Response: 3
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)C[NH+]([5*])C Fragment 2: [1*]C(=O)C([1*])=O ### Response: CCCC[NH+](C)CC(=O)N1CCN(C(=O)C(=O)N2CCCC2)CC1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C(CCNc1cnc2ccccc2n1)N1CCCCC1 ### Response: 3
canonicalization
### Instruction: Canonicalize the following SMILES string. c1cc(ccc1/C=C/C[NH2+][C@H]1CCN(c2ccc(cc2)C)C1=O)C#N ### Response: Cc1ccc(N2CC[C@H]([NH2+]C/C=C/c3ccc(C#N)cc3)C2=O)cc1
functional_group
### Instruction: Does the molecule contain a amide group? Cc1nc(C)c(-c2nnc(NC(=O)[C@@H]3CCC(=O)N3)o2)s1 ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COc1cc(C(=O)/C=C/c2ccccc2C)ccc1O ### Response: 3
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N[C@H]1CC[C@H]([15*])C1 Fragment 2: [5*]N([5*])Cc1ccco1 ### Response: CNC(=O)c1ccc(CN(Cc2ccco2)C(=O)N[C@H]2CC[C@H]([NH+](C)C)C2)cc1
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? c1ccc2c(c1)CCCN2[C@H]1CCC[NH2+]C1 ### Response: Yes
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CC[S@@](=O)[C@H]1CCCC[C@@H]1[NH2+]Cc1cc(C)ccc1OC(F)F ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC(C)[C@H](NC(=O)c1ccco1)C(=O)NNC(=O)C(C)(C)C ### Response: 4
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COc1ccc(-c2csc(NC(=O)Cc3ccc(SC)cc3)n2)c(OC)c1 ### Response: 2
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CN(C)c1ccc(S(=O)(=O)N2CCCCC2)cc1NCc1cc2ccccc2nc1Cl ### Response: 4
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCOCCC(=O)Nc1c(C)cnn1[C@@H]1CCCc2ccccc21 ### Response: 3
functional_group
### Instruction: Does the molecule contain a carboxyl group? COc1ncnc(N)c1C[NH+]1CCC(c2cnn(C)c2)CC1 ### Response: No
functional_group
### Instruction: Does the molecule contain a amine group? Clc1ccc(CNc2ncccc2Cl)cn1 ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. N(CCOc1ccccc1)C(c1nnn(C[C@H]2CCCO2)c1)=O ### Response: O=C(NCCOc1ccccc1)c1cn(C[C@H]2CCCO2)nn1
canonicalization
### Instruction: Canonicalize the following SMILES string. [C@@H]1(NC(=O)N(C)C(=C1C(=O)OCC=C)C)c1c(cccc1)I ### Response: C=CCOC(=O)C1=C(C)N(C)C(=O)N[C@@H]1c1ccccc1I
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COc1ccc2c(c1)[C@@]([NH3+])(Cc1cccs1)CCC2 ### Response: 1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CCNS(=O)(=O)[C@H]1CCN(C(=O)/C=C/c2cccc(OC)c2)C1 ### Response: 1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CC(=O)N1c2cc(S(=O)(=O)[N-]c3cccc(C(F)(F)F)c3)c(Br)cc2C[C@H]1C ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1csc([C@@H](NC(=O)N2c3ccccc3C[C@H]2C)C2CC2)n1 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC[C@@H]1Oc2cc(S(=O)(=O)N(C)CC(=O)NCc3ccccc3Cl)c(C)cc2NC1=O ### Response: 2
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CCC(=O)N1CCCc2cc([C@@H](O)CN3CCN(c4cnccn4)CC3)ccc21 ### Response: 0
ring_counting
### Instruction: Count the five-membered rings in the following molecule. COc1ccc(F)cc1NC(=O)C(=O)N[C@@H]1CCCC[C@H]1OC1CCCC1 ### Response: 1
functional_group
### Instruction: Does the molecule contain a amide group? CC(C)CC(C)(C)C(=O)N(C)CCNS(C)(=O)=O ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N1CCCC[C@@H]1[13*] Fragment 2: [14*]c1nc(N)ncc1[16*] ### Response: COc1cccc(-c2cnc(N)nc2[C@H]2CCCCN2C(=O)Cc2c[nH]c3ccccc23)c1
canonicalization
### Instruction: Canonicalize the following SMILES string. O1[C@@H]([C@H](CC1)C(=O)NC[C@@H](c1c(cccc1F)F)O)C ### Response: C[C@H]1OCC[C@@H]1C(=O)NC[C@H](O)c1c(F)cccc1F
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1ccccc1O[C@@H](C)C(=O)O/N=C(\N)c1cccc([N+](=O)[O-])c1 ### Response: 3
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC(C)CC[C@@H]1CCCN1C(=O)c1scnc1C1CC1 ### Response: 4
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)C(C)(C)CC(C)C Fragment 2: [5*]NC(C)C ### Response: CC(C)CC(C)(C)C(=O)Nc1ccc(C(=O)NC(C)C)cc1
canonicalization
### Instruction: Canonicalize the following SMILES string. C1CCC(C1)Oc1cc(C[NH2+]Cc2ccco2)ccc1 ### Response: c1cc(C[NH2+]Cc2ccco2)cc(OC2CCCC2)c1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]Cc1ccc2c(c1)Cc1ccccc1-2 Fragment 2: [5*][NH+]1CC[C@@]2(CCCN(C)C2=O)C1 ### Response: CN1CCC[C@@]2(CC[NH+](Cc3ccc4c(c3)Cc3ccccc3-4)C2)C1=O
canonicalization
### Instruction: Canonicalize the following SMILES string. Fc1c(C(=S)N)c(N[C@@H]2CCCc3ccccc32)ccc1 ### Response: NC(=S)c1c(F)cccc1N[C@@H]1CCCc2ccccc21
canonicalization
### Instruction: Canonicalize the following SMILES string. c1cc(Cl)c(NC(=O)c2cnc3ccc(cn3c2=O)C)cc1 ### Response: Cc1ccc2ncc(C(=O)Nc3ccccc3Cl)c(=O)n2c1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CCCCC(=O)Nc1ccc(C)cc1NC(=O)[C@H]1C=CC[NH2+]1 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [16*]c1ccccc1C Fragment 2: [5*]N([5*])CC ### Response: CCN(CCC#N)[C@H](C)C(=O)N[C@@H](C)c1ccccc1C
canonicalization
### Instruction: Canonicalize the following SMILES string. [C@@H]1(C[NH2+]CC)[C@@H](c2ccc(cc2)CC(C)C)OCCC1 ### Response: CC[NH2+]C[C@H]1CCCO[C@@H]1c1ccc(CC(C)C)cc1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COc1ccc2c(c1)[C@@H]([NH2+]C[C@@H](C)SC)CCCO2 ### Response: 3
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CNS(=O)(=O)c1cc(C(=O)NCc2ccc3c(c2)OCCO3)ccc1OC ### Response: 0
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]Cc1cc(C)c(C)cc1O Fragment 2: [5*][NH+]1CCc2ccccc2C1 ### Response: Cc1cc(O)c(C[NH+]2CCc3ccccc3C2)cc1C
functional_group
### Instruction: Does the molecule contain a sulfonyl group? O=C(Cc1ccc(/N=C2\N[C@H]3CS(=O)(=O)C[C@@H]3S2)cc1)NCCC1=CCCCC1 ### Response: Yes
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Cc1ccc2c(c1)NC(=O)[C@H](C(=O)N1CCN(c3ccccc3F)CC1)O2 ### Response: 0
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@@H](CNC(=O)NCCc1cccnc1)C[NH+]1CCCC1 ### Response: 3
functional_group
### Instruction: Does the molecule contain a ether group? CCN(C[C@H](C)C#N)c1ncnc2ccc(C)cc12 ### Response: No
functional_group
### Instruction: Does the molecule contain a amide group? CC[NH+](CC)[C@@H]1CCN(CC(=O)N2[C@H](C)CCC[C@@H]2C)C1 ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Fc1ccccc1-c1noc(Cc2nnc(-c3ccc(Cl)cc3)o2)n1 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1nc2ccc(NC(=O)N3CCC[C@@H](C)CC3)cc2o1 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCN(CC)[C@H]1CC[NH+](Cc2nnc(C(C)(C)C)o2)C1 ### Response: 3
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C([O-])[C@@H]1[C@@H](C(=O)N2CCN(C/C=C/c3ccccc3)CC2)[C@@H]2C=C[C@H]1C2 ### Response: 3
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? Cc1cc(C[C@@H]2COC[C@H]2[NH2+]Cc2ccc(C(F)(F)F)cc2)on1 ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. [NH2+]1CCCCC[C@@H]1C[C@H]([NH2+]C[C@H](COC)C)C ### Response: COC[C@H](C)C[NH2+][C@H](C)C[C@H]1CCCCC[NH2+]1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C(CSc1ccncc1)NCc1cc(Cl)c2c(c1)OCCO2 ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. [C@H]1(c2ccccc2)SC(NCc2c(C)csc2)=[NH+]C1 ### Response: Cc1cscc1CNC1=[NH+]C[C@@H](c2ccccc2)S1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(ccccc1)S(=O)(=O)N(c1cccc(C)c1)CC(N1CC[NH+](CC1)C)=O ### Response: Cc1cccc(N(CC(=O)N2CC[NH+](C)CC2)S(=O)(=O)c2ccccc2)c1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C(C[S@@](=O)Cc1ccccc1Cl)Nc1ccc(OC(F)F)cc1 ### Response: 2
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CC[C@H](C)C(=O)Nc1ccccn1 ### Response: 0
canonicalization
### Instruction: Canonicalize the following SMILES string. N1(CCOCC1)NC(CCc1c([nH]c2ccccc21)-c1ccc(F)cc1)=O ### Response: O=C(CCc1c(-c2ccc(F)cc2)[nH]c2ccccc12)NN1CCOCC1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1cc(Cl)cn2c1nc(C(N1CCc3c(C1)nc(N(C)C)[nH]c3=O)=O)c2 ### Response: CN(C)c1nc2c(c(=O)[nH]1)CCN(C(=O)c1cn3cc(Cl)ccc3n1)C2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)c1ccc(Cl)cc1N[5*] Fragment 2: [5*]N[C@H]1CCN(C)C1=O ### Response: CCNC(=O)c1ccc(Cl)cc1N[C@H]1CCN(C)C1=O
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCc1cnc([C@H](C)NC(=O)NCc2ccc([S@](C)=O)cc2)s1 ### Response: 2
functional_group
### Instruction: Does the molecule contain a phenol group? CNS(=O)(=O)c1cc(C(=O)N2CC[C@H](C)[C@H]3CCCC[C@H]32)ccc1F ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(ccc(c(c1)C)N1CCN(C(c2c(cc(cc2)Cl)OC)=O)CC1)C ### Response: COc1cc(Cl)ccc1C(=O)N1CCN(c2ccc(C)cc2C)CC1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [6*]C(=O)/C=C/NNC([6*])=O Fragment 2: [16*]c1ccccc1O ### Response: COc1ccc(C(=O)/C=C/NNC(=O)c2ccccc2O)cc1
functional_group
### Instruction: Does the molecule contain a nitro group? COC(=O)[C@H](c1ccccc1)N1CC[NH+](C2CCCC2)CC1 ### Response: No
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@H]1CN(C)C[C@H](C)N1C(=O)CCC(F)(F)F ### Response: 4
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [16*]c1cccc(F)c1 Fragment 2: [5*]NCC(C)(C)O ### Response: CC(C)(O)CNC(=O)[C@@H]1C[C@@H]1c1cccc(F)c1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]Nc1ccc(OC)cc1 Fragment 2: [9*]n1nc([14*])c2c(c1=O)CCCC2 ### Response: COc1ccc(NC(=O)[C@@H](C)n2nc(-c3ccc(C)cc3)c3c(c2=O)CCCC3)cc1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CSc1ccc(N[C@@H]2C[C@H](C)N(c3ccccc3)C2)[nH+]n1 ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. C(C(=O)Nc1ccc(OC)c(Cl)c1)[C@@H]1[NH2+]CCNC1=O ### Response: COc1ccc(NC(=O)C[C@@H]2[NH2+]CCNC2=O)cc1Cl
ring_counting
### Instruction: Count the five-membered rings in the following molecule. C=CCc1ccc(OCc2nc3cc(C)ccc3[nH]2)cc1 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. n1(C(F)F)c2ccccc2nc1-c1ccc(cc1)[N-]S(=O)(=O)c1ccsc1C([O-])=O ### Response: O=C([O-])c1sccc1S(=O)(=O)[N-]c1ccc(-c2nc3ccccc3n2C(F)F)cc1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(S(=O)(N[C@@H]2C=C[C@H](C2)C(=O)[O-])=O)cn(C)c(C(N)=O)c1 ### Response: Cn1cc(S(=O)(=O)N[C@@H]2C=C[C@@H](C(=O)[O-])C2)cc1C(N)=O
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1nc([C@@H](C)NCCc2ccccc2)cs1 ### Response: 2
functional_group
### Instruction: Does the molecule contain a amine group? CN(c1ccc2sc(C(=O)N3CCOCC3)cc2c1)S(C)(=O)=O ### Response: No
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)c1cc2ccccc2cc1N[5*] Fragment 2: [5*]N([5*])CCC ### Response: CCCN(CCC)C(=O)c1cc2ccccc2cc1NC(=O)C1CC1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC[C@@H](Cc1ccccc1)[NH2+]C[C@@H](O)c1c(F)cccc1F ### Response: 4
functional_group
### Instruction: Does the molecule contain a halide group? NC(=O)c1ccsc1NC(=O)CCSc1ncccc1Cl ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]Nc1ccc(OC)nc1 Fragment 2: [5*]N1CCC[C@@H](CC)C1 ### Response: CC[C@@H]1CCCN(C(=O)Nc2ccc(OC)nc2)C1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N1CCC[NH+]([5*])CC1 Fragment 2: [4*]Cc1ccc([S@](C)=O)cc1 ### Response: C[S@](=O)c1ccc(C[NH+]2CCCN(C(=O)c3ccc(Cl)cc3)CC2)cc1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]Nc1ccc([16*])cc1 Fragment 2: [5*]N[C@H](C)CCC(C)(C)C ### Response: Cc1nnc(-c2ccc(NC(=O)C(=O)N[C@H](C)CCC(C)(C)C)cc2)o1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)C[4*] Fragment 2: [5*]N(C)S(=O)(=O)c1cccs1 ### Response: C[C@@H]1CCCC[C@@H]1NC(=O)CN(C)S(=O)(=O)c1cccs1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CC(C)C[C@H](C[NH3+])CN1CC[NH+](CC2CC2)CC1 ### Response: 0
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N1CCN([5*])CC1 Fragment 2: [1*]C(=O)c1cc(C)nc2c1c(=O)[nH]n2C ### Response: Cc1cc(C(=O)N2CCN(Cc3ccccn3)CC2)c2c(=O)[nH]n(C)c2n1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC(C)C[NH+](C)[C@@H]1C[C@@H](C)CC[C@H]1C#N ### Response: 3
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Cc1ccccc1[C@@H](C)CC(=O)N1CCCC1 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COc1ccccc1N(C)S(=O)(=O)c1ccc(C(=O)Nc2cccc([N+](=O)[O-])c2C)cc1 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. O=C(C1=C(O)C(=O)N([C@H]1c1ccc(c(OC)c1)O)c1sc(C)nn1)c1oc2c(c1)cccc2 ### Response: COc1cc([C@H]2C(C(=O)c3cc4ccccc4o3)=C(O)C(=O)N2c2nnc(C)s2)ccc1O