task
stringclasses
5 values
input
stringlengths
89
339
ring_counting
### Instruction: Count the six-membered rings in the following molecule. O=C(COC(=O)CNC(=O)c1cccc(Br)c1)Nc1ncc(Cl)cc1Cl ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1ccc2c(c1)CCN2C(=O)[C@H]1Cc2cc(F)ccc2O1 ### Response: 1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CC(C)N(CC(=O)NC(=O)NC(C)(C)C)Cc1ccc([N+](=O)[O-])cc1 ### Response: 0
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC(C)c1ccsc1C(=O)NCC1CCN(c2cc[nH+]cc2)CC1 ### Response: 3
functional_group
### Instruction: Does the molecule contain a amide group? COc1ccccc1N1CC[C@H](N[C@@H](C)c2ccccn2)C1=O ### Response: Yes
ring_counting
### Instruction: Count the five-membered rings in the following molecule. C#CC(C)(C)NC(=O)c1ccc(OC)c(O)c1 ### Response: 0
canonicalization
### Instruction: Canonicalize the following SMILES string. C1(CC1)NC(CCNC(=O)[C@H](CC)C#N)=O ### Response: CC[C@H](C#N)C(=O)NCCC(=O)NC1CC1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [15*]C1CCCCC1 Fragment 2: [4*][C@@H]([8*])C(N)=O ### Response: CC(C)(C)OC(=O)N[C@H](C(N)=O)C1CCCCC1
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? O=C(CSc1nnc(C2CC2)s1)Nc1ccc(F)cc1F ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@H]([NH2+][C@H](C)C(=O)Nc1cc(F)ccc1F)c1ccc2c(c1)OCCO2 ### Response: 3
functional_group
### Instruction: Does the molecule contain a amine group? CC1=C([C@H](NC(=O)[C@@H]2C=C(c3ccccc3)NN2C)C(=O)[O-])[C@@H](C)N=N1 ### Response: Yes
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CCN(CCO)c1ncnc2c1sc1nc(CC(C)C)c3c(c12)CC(C)(C)OC3 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1cc(Cl)c([N+](=O)[O-])cc1NC(=O)CCn1cc[nH+]c1C(C)C ### Response: 3
functional_group
### Instruction: Does the molecule contain a ketone group? CC(C)CN1CCO[C@@H](CNC(=O)C(=O)Nc2ccccc2N(C)C)C1 ### Response: No
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC[NH+]1CCN(CCC(=O)N2CCO[C@H](c3ccc(F)cc3)C2)CC1 ### Response: 3
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CCC[C@H]1C(=O)NC(=O)C[C@H]1c1ccc(CC)s1 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1ccc(CCC(=O)N[C@@H](c2ccccc2)c2ccncc2)cc1 ### Response: 3
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [14*]c1cccs1 Fragment 2: [4*][C@H]([8*])CN[5*] ### Response: Cc1cccc(OCC(=O)NC[C@@H](c2cccs2)[NH+]2CCCCCC2)c1C
ring_counting
### Instruction: Count the five-membered rings in the following molecule. C[C@@]12CC(=O)N[C@@H]1N(C(=O)c1cccc(C(F)(F)F)c1)[C@H](c1ccccc1O)C2 ### Response: 2
ring_counting
### Instruction: Count the five-membered rings in the following molecule. O=C(Nc1ccc(C(=O)OCc2cc(=O)n3nc(C4CCCCC4)sc3n2)cc1)c1ccccc1 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1cc(C[NH2+][C@@H]2Cc3c([nH]c4ccccc34)CC2)ccc1-n1cncc1 ### Response: c1ccc2c3c([nH]c2c1)CC[C@H]([NH2+]Cc1ccc(-n2ccnc2)cc1)C3
functional_group
### Instruction: Does the molecule contain a ester group? C[C@H]1CCC[C@@H](CNc2ccc(C(=O)NCCCO)cc2)C1 ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. C1(=O)C=CC(=O)N1CNc1ccccc1 ### Response: O=C1C=CC(=O)N1CNc1ccccc1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]Cc1cc(C)no1 Fragment 2: [4*]C[C@H]([8*])O ### Response: Cc1cc(CN2CCN(C[C@@H](O)c3ccc(F)cc3)CC2)on1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1ccc(NC(=O)C(=O)NCc2ccccc2C)c(Cl)c1 ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*][C@H](CN[5*])C(C)C Fragment 2: [1*]C(=O)c1cnc2ccc(C)cn12 ### Response: Cc1ccc2ncc(C(=O)NC[C@H](C(C)C)N3CC[NH+](C)CC3)n2c1
functional_group
### Instruction: Does the molecule contain a aldehyde group? CCOC(=O)c1ccc(CNc2ccc(C)cc2)o1 ### Response: No
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COCCN1C[C@H](C(=O)Oc2cccc(C(C)(C)C)c2)CC1=O ### Response: 3
ring_counting
### Instruction: Count the six-membered rings in the following molecule. OCC1(C[NH2+][C@H](c2ccccc2)C2CCCC2)COC1 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. O=C(N)c1ccnc(c1)N[C@@H](C)C(=O)N1CCCC[C@H]1C ### Response: C[C@H](Nc1cc(C(N)=O)ccn1)C(=O)N1CCCC[C@H]1C
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Cc1nn([C@H]2CCS(=O)(=O)C2)c(C)c1C(=O)NCc1cccc(Cl)c1 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1ccccc1C[C@]1(O)CCCS[C@H]1C ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. o1c(-c2ccc(c(c2)Cl)OC)ccc1CNc1n(CCC)nnn1 ### Response: CCCn1nnnc1NCc1ccc(-c2ccc(OC)c(Cl)c2)o1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)c1cc([14*])nc2c1cnn2[9*] Fragment 2: [5*]N1CCCN([5*])CC1 ### Response: Cc1cc(-c2cc(C(=O)N3CCCN(C(=O)OCC(C)C)CC3)c3cnn(C(C)C)c3n2)c(C)s1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. COc1ccc(CCC(=O)N2CCN(c3ccc(C#N)c(Cl)c3)CC2)cc1 ### Response: 0
functional_group
### Instruction: Does the molecule contain a ester group? Cc1ccc([O-])c(CN[C@@H]2CCO[C@H]2c2ccc(Cl)c(F)c2)[nH+]1 ### Response: No
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)CN([5*])[5*] Fragment 2: [5*]N1CCn2cccc2[C@H]1c1ccccc1OC ### Response: COc1ccccc1[C@@H]1c2cccn2CCN1C(=O)CN(C(=O)c1ccco1)C(C)C
functional_group
### Instruction: Does the molecule contain a carboxyl group? CCc1cnc(CN(C)C(=O)NCCc2ncc(C)s2)s1 ### Response: No
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [14*]c1nc(/C([O-])=N/S(=O)(=O)CCCF)cs1 Fragment 2: [16*]c1ccc(C)cc1 ### Response: Cc1ccc(-c2nc(/C([O-])=N/S(=O)(=O)CCCF)cs2)cc1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COCc1cc(C[NH+]2CCC[C@@H]2[C@@H]2CCCCC2=O)no1 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. O(C[C@H]1CCCO1)[C@@H](C)C(=O)Nc1cn(C)c(cc1C)=O ### Response: Cc1cc(=O)n(C)cc1NC(=O)[C@H](C)OC[C@H]1CCCO1
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? CCCN1C(=O)[C@@]2(C(C(=O)OC)=C(N)Oc3cc(C)n(Cc4ccncc4)c(=O)c32)c2ccccc21 ### Response: Yes
functional_group
### Instruction: Does the molecule contain a aldehyde group? Cn1cc(Cl)c(C(=O)OCC(=O)Nc2ccccc2Cl)n1 ### Response: No
functional_group
### Instruction: Does the molecule contain a ester group? O=C(Nc1nc2ccccc2[nH]1)c1ccc(CS(=O)(=O)c2ccccc2)o1 ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. c1c(-c2oncc2)sc(S(=O)(N2CCN(c3cc[nH+]cc3)CC2)=O)c1 ### Response: O=S(=O)(c1ccc(-c2ccno2)s1)N1CCN(c2cc[nH+]cc2)CC1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CC(C)CN(C(=O)Cc1ccccc1Cl)c1c(N)n(CC(C)C)c(=O)[nH]c1=O ### Response: 0
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [14*]c1cccs1 Fragment 2: [5*]N(C)[C@H](C)C[8*] ### Response: C[NH2+][C@H]1COC[C@@H]1C(=O)N(C)[C@H](C)Cc1cccs1
canonicalization
### Instruction: Canonicalize the following SMILES string. C1[C@](C(=O)N)([C@H](CCSc2ccncc2)CC1)[NH3+] ### Response: NC(=O)[C@@]1([NH3+])CCC[C@H]1CCSc1ccncc1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [3*]OCC Fragment 2: [1*]C(=O)[C@@H]([4*])C ### Response: CCOC[C@@H]1CCN(C(=O)[C@H](C)Sc2nncn2C)C1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? NC(=O)c1c(NC(=O)COC(=O)/C=C/c2cccc(F)c2)sc2c1CCC2 ### Response: 3
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? Cc1ccc([C@@H](C)NS(=O)(=O)c2c[nH]c(C(C)C)n2)cc1 ### Response: Yes
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CC(C)[C@H](C)[NH+]1Cc2cccc(NCc3cc(=O)n4ccsc4[nH+]3)c2C1 ### Response: 2
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CCC[C@H](C)C[NH2+]CC(C)(C)S(C)(=O)=O ### Response: 0
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CC[C@H](C)C(=O)NCC(=O)NCc1ccc(C(=O)N(C)C)cc1 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [9*]n1cncn1 Fragment 2: [8*]CC(C)C ### Response: CC(C)Cc1cc(C(=O)N2CCC[C@@H](n3cncn3)C2)[nH]n1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)C[4*] Fragment 2: [5*]N1CC[NH+]([5*])CC1 ### Response: O=C(C[NH+]1CCN(C(=O)c2ccco2)CC1)Nc1c2c(nc3ccccc13)CCC2
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(COc2c(NC(=O)C)ccc(c2)C)c(cccc1)C#N ### Response: CC(=O)Nc1ccc(C)cc1OCc1ccccc1C#N
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CC(C)OCC(=O)CSC1CCCC1 ### Response: 0
functional_group
### Instruction: Does the molecule contain a thiol group? C[C@H]1CCN(C(=O)c2cc(=O)[nH]c3c(Br)cccc23)C[C@@H]1O ### Response: No
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Cc1cccc(-n2c(C)cc(/C=C3\C(=N)N4N=C(Cc5ccccc5)SC4=NC3=O)c2C)c1 ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCN(CCC[NH+]1CCCC1)CC1CC[NH2+]CC1 ### Response: 3
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)[C@@H](C)O[3*] Fragment 2: [5*]NC(C)(C)CC ### Response: CCC(C)(C)NC(=O)[C@@H](C)Oc1ccc(C[C@H](C)[NH3+])nc1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C(NC[C@@H](O)c1cccc(F)c1)c1cccc(Cl)c1 ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. c1cnc(N)c(C(NC[C@@H](c2onc(-c3ccccc3)n2)C)=O)n1 ### Response: C[C@@H](CNC(=O)c1nccnc1N)c1nc(-c2ccccc2)no1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1ccc(CNC(=O)c2ccc(S(N)(=O)=O)o2)c(N(C)C)c1 ### Response: 1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CNC(=O)c1c(C)cccc1NC(=O)[C@H]1CC(=O)N(C2CCC(C)CC2)C1 ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1ccc(-c2nc(C)c(C(=O)N[C@@]3(C#N)CCSC3)s2)c(C)c1 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [13*][C@H]1Sc2ccc([16*])cc2NC1=O Fragment 2: [5*]NCc1ccc([14*])[nH+]c1 ### Response: O=C(C[C@H]1Sc2ccc(C(F)(F)F)cc2NC1=O)NCc1ccc(N2CCOCC2)[nH+]c1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*][NH2+][C@H]1CCN([5*])C[C@H]1CC Fragment 2: [4*]Cc1ccc(Cl)c(F)c1 ### Response: CC[C@@H]1CN(C(C)=O)CC[C@@H]1[NH2+]Cc1ccc(Cl)c(F)c1
canonicalization
### Instruction: Canonicalize the following SMILES string. C1(CCC(CC1)O)NC(=O)NCc1cc(ncc1)OC1CCC(CC1)C ### Response: CC1CCC(Oc2cc(CNC(=O)NC3CCC(O)CC3)ccn2)CC1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1cccc(C)c1NC(=O)NCCNC(=O)c1ccc(Cl)cc1 ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. [C@]12(CCC[C@@H](C)[C@]1(CCCC2)O)C ### Response: C[C@@H]1CCC[C@@]2(C)CCCC[C@]12O
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CCn1c(S[C@H](C)C(=O)N2CCc3ccccc32)nnc1-c1cccs1 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. s1c(nc(c1)Br)N1CCN(CC1)c1ccccc1OC ### Response: COc1ccccc1N1CCN(c2nc(Br)cs2)CC1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CC(C)c1ccccc1-n1c(S[C@H](C)C(=O)NC(N)=O)nnc1-c1ccc(Cl)cc1 ### Response: 2
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Cn1c(=O)c2nc(C[NH+]3CCC[C@H]3CC(C)(C)C)[nH]c2n(C)c1=O ### Response: 1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Cc1ccc(C[C@H](NC(=O)N(C)C[C@@H](C)O)c2ccccn2)cc1 ### Response: 0
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [16*]c1cc(C)ccc1C Fragment 2: [7*]Cc1ccc(C)o1 ### Response: Cc1ccc(C)c(NCN2C(=O)S/C(=C\c3ccc(C)o3)C2=O)c1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [14*]c1ccco1 Fragment 2: [5*]N([5*])C[C@@H]([8*])O ### Response: O=C(Cc1ccc[nH]1)N(Cc1ccccc1)C[C@H](O)c1ccco1
canonicalization
### Instruction: Canonicalize the following SMILES string. o1c(CN(C[C@H]2CCCO2)C(=O)NCc2sc(c(C)n2)C)ccc1 ### Response: Cc1nc(CNC(=O)N(Cc2ccco2)C[C@H]2CCCO2)sc1C
functional_group
### Instruction: Does the molecule contain a phenol group? O=C(NCC1(O)CCOCC1)c1cc([N+](=O)[O-])ccc1N1CCCCC1 ### Response: No
functional_group
### Instruction: Does the molecule contain a phenol group? COc1ncccc1C[S@](=O)c1nc2ccc(N)cc2o1 ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. [C@H]1([C@H](C)[C@@H]([S@@](=O)c2c1cc(F)c(F)c2)C)[NH2+]C ### Response: C[NH2+][C@H]1c2cc(F)c(F)cc2[S@](=O)[C@@H](C)[C@H]1C
ring_counting
### Instruction: Count the six-membered rings in the following molecule. FC(F)(F)c1ccccc1CN(Cc1cnc[nH]1)C1CCCC1 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)C[8*] Fragment 2: [9*]n1cc(S[11*])c2ccccc21 ### Response: O=C(Cn1cc(SCc2ccc(F)cc2)c2ccccc21)N1CCCC1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. COc1ccc(C[NH+]2CC[C@H](S(=O)(=O)N3CCCC3)C2)c(O)c1 ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. C(CCCc1ccccc1)(N1CCCC[C@H]1c1nc(no1)CC)=O ### Response: CCc1noc([C@@H]2CCCCN2C(=O)CCCc2ccccc2)n1
canonicalization
### Instruction: Canonicalize the following SMILES string. COc1ccc(cc1Cl)NC([C@@H]1CSc2nc(C)c(CC)c(=O)n2C1)=O ### Response: CCc1c(C)nc2n(c1=O)C[C@H](C(=O)Nc1ccc(OC)c(Cl)c1)CS2
functional_group
### Instruction: Does the molecule contain a amide group? CC1=C(C)C[C@@H](C(=O)N[C@@H](C)CCc2ccccc2)[C@H](C(=O)[O-])C1 ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. C1[C@@H](C(Nc2cc(C(=O)NCC(c3cccs3)(C)C)ccc2)=O)[C@H]1C ### Response: C[C@H]1C[C@H]1C(=O)Nc1cccc(C(=O)NCC(C)(C)c2cccs2)c1
functional_group
### Instruction: Does the molecule contain a ether group? COCC(=O)C[C@H]1CCO[C@@]2(CCSC2)C1 ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC1(C)C[C@@H](N2CCC[C@H]([C@@H]3CCC[NH2+]3)C2)C(C)(C)O1 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC[C@H](O)CCNC(=O)Nc1ccc(C(C)=O)c(C)c1 ### Response: 5
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CC(C)OC[C@@H](O)Cn1ccnc1C#N ### Response: 0
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [16*]c1cccc(F)c1F Fragment 2: [4*]C[C@@H]([4*])C(CC)CC ### Response: CCC(CC)[C@@H](CNC(=O)Nc1cccc(F)c1F)N1CCOCC1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [11*]Sc1nnc2n1CCCCC2 Fragment 2: [16*]c1ccc(OC)cc1 ### Response: COc1ccc(-c2cnc(CSc3nnc4n3CCCCC4)o2)cc1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]CCOC Fragment 2: [16*]c1ccc2c(C)cc(=O)oc2c1 ### Response: COCCOc1ccc2c(C)cc(=O)oc2c1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. NS(=O)(=O)c1ccc(CCNC(=O)c2c3c(nc4ccccc24)CCCCC3)cc1 ### Response: 3
canonicalization
### Instruction: Canonicalize the following SMILES string. C1CC[C@@H](NC(N(Cc2cccc(C)n2)Cc2cccc(C)n2)=O)[C@H](C1)CC ### Response: CC[C@H]1CCCC[C@H]1NC(=O)N(Cc1cccc(C)n1)Cc1cccc(C)n1
functional_group
### Instruction: Does the molecule contain a halide group? C[C@@](NC(=O)CSCc1ccccc1)(C(=O)[O-])C1CC1 ### Response: No