task
stringclasses
5 values
input
stringlengths
89
339
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(onc(n1)-c1nccnc1)C(N[C@H](C)c1ccccc1)=O ### Response: C[C@@H](NC(=O)c1nc(-c2cnccn2)no1)c1ccccc1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [3*]OCC Fragment 2: [5*]N1CCCC1 ### Response: CCOc1cc(C=O)ccc1N1CCCC1
canonicalization
### Instruction: Canonicalize the following SMILES string. n1cc(cn1CC(=O)Nc1nn(c2c1cccc2)C)-c1cncc(OC)c1 ### Response: COc1cncc(-c2cnn(CC(=O)Nc3nn(C)c4ccccc34)c2)c1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1ccc(cc1)/C=C/C=N/NC(COc1c(cc(C)cc1)C)=O ### Response: Cc1ccc(OCC(=O)N/N=C/C=C/c2ccccc2)c(C)c1
canonicalization
### Instruction: Canonicalize the following SMILES string. Cc1cn2c3c(nc2n1-c1cc(C)c(C)cc1)n(c(n(CCC(OC)=O)c3=O)=O)C ### Response: COC(=O)CCn1c(=O)c2c(nc3n(-c4ccc(C)c(C)c4)c(C)cn23)n(C)c1=O
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)[C@H]1CCCCO1 Fragment 2: [5*]N1CCO[C@H](/C(N)=N\O)C1 ### Response: N/C(=N/O)[C@@H]1CN(C(=O)[C@H]2CCCCO2)CCO1
functional_group
### Instruction: Does the molecule contain a ester group? C[C@@H](OC(=O)c1occc1-c1ccccc1)C(=O)Nc1ccc(F)cc1F ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@@H](CS(C)(=O)=O)N(C)Cc1csc(-c2ccc(C(N)=O)cc2)n1 ### Response: 3
canonicalization
### Instruction: Canonicalize the following SMILES string. C([C@@H](n1c2c(cccc2)nn1)C[C@H](CCl)C)=C ### Response: C=C[C@H](C[C@@H](C)CCl)n1nnc2ccccc21
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CC[C@H]1CN(C)c2ccccc2CN1C(=O)[C@@H](C)NC(=O)C1CCC1 ### Response: 0
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1ccc(C(=O)N(C)C)cc1OC(=O)c1cc(F)ccc1NC(=O)[C@H]1C[C@H]1C ### Response: 1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. COc1ccccc1/C=c1\s/c(=C(/C#N)C(=O)N[C@@H]2CCCC[C@@H]2C)n(-c2ccc(F)cc2)c1=O ### Response: 3
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COCCSc1ccc([C@@H](C)NC(=O)c2ccc[nH]2)cc1 ### Response: 2
ring_counting
### Instruction: Count the six-membered rings in the following molecule. COc1cccc(NC(=O)CN(C)c2nc3c(OC)cccc3s2)c1 ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)C1=C(C)N(C)C(=O)N[C@H]1[13*] Fragment 2: [16*]c1cccc([N+](=O)[O-])c1 ### Response: CCCOC(=O)C1=C(C)N(C)C(=O)N[C@H]1c1cccc([N+](=O)[O-])c1
functional_group
### Instruction: Does the molecule contain a amide group? CC(C)CCNC(=O)c1ccc(/C=C2/Sc3ccccc3NC2=O)cc1 ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. C1C(C1)[C@@H](N(C(NCCNC(C)=O)=O)C)C ### Response: CC(=O)NCCNC(=O)N(C)[C@@H](C)C1CC1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [11*]Sc1nnc([14*])n1N Fragment 2: [1*]C(=O)[C@@H]([4*])C ### Response: Cc1ccc(-c2nnc(S[C@@H](C)C(=O)Nc3nc(-c4ccccc4)cs3)n2N)cc1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CCc1ccc(OCC(=O)Nc2ccc(OC)c(OC)c2)cc1 ### Response: 0
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? N#Cc1cccc(CSc2nnc(C3CC3)n2Cc2ccccc2)c1 ### Response: Yes
functional_group
### Instruction: Does the molecule contain a ether group? CCC(CC)Oc1ccc(C)nc1CCl ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COc1ccc(/C=C/C(=O)N[C@@H](C)C(=O)N(C)C2CC2)cc1 ### Response: 3
ring_counting
### Instruction: Count the five-membered rings in the following molecule. O=C(Nc1ccc(Cl)c(Cl)c1)N1CC[NH+](C[C@@H]2CCCO2)CC1 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. O=S(c1cccc(c1)CNC(=O)c1n(C)c(C)cc1)(N)=O ### Response: Cc1ccc(C(=O)NCc2cccc(S(N)(=O)=O)c2)n1C
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? COc1ccccc1/C=C/C[NH+]1CCN(CCO)CC1 ### Response: Yes
functional_group
### Instruction: Does the molecule contain a hydroxyl group? CCN(CC)c1ncc(CN(C)C[C@@H]2CCC[NH+](C)C2)s1 ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. c1c(C)c(NC(=O)c2cc(nc3c2cnn3CC)-c2sccc2)cc(c1)C ### Response: CCn1ncc2c(C(=O)Nc3cc(C)ccc3C)cc(-c3cccs3)nc21
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@H](NCC(=O)N[C@H](C)c1ccc2c(c1)CCCC2)c1ccc2c(c1)OCCO2 ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCOc1ccc(CNC(=O)[C@H](CC)N2C(=O)CCn3nc(C)cc32)cc1 ### Response: 4
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CC(C)CCNC(=O)[C@@H](NC(=O)[C@@H]1Cc2c([nH]c3ccccc23)[C@H]2c3ccccc3C(=O)N21)C(C)C ### Response: 3
ring_counting
### Instruction: Count the six-membered rings in the following molecule. C#CCNC(=O)c1ccc(NC[C@@H](C)Oc2cccc(F)c2)nc1 ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COCCOc1ccc(NC(=O)C2C[C@H](C)O[C@@H](C)C2)c(C)c1 ### Response: 2
ring_counting
### Instruction: Count the five-membered rings in the following molecule. COc1ccc(CCn2c(C)cc(-c3csc(CC(=O)N4CCOCC4)n3)c2C)cc1 ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@@H](Nc1ccc(OCC(F)(F)F)cc1)C(=O)N1CCNC1=O ### Response: 3
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=S1(=O)C[C@@H]2[NH+]=C([S-])N(c3cccc(Br)c3)[C@H]2C1 ### Response: 0
ring_counting
### Instruction: Count the six-membered rings in the following molecule. O=C(c1nc(C2CC2)n2ccccc12)N1CCOc2cccc(F)c21 ### Response: 3
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(F)ccc(F)cc1[C@]1(C)C(N(C[C@@H]2OCCCC2)C(=O)N1)=O ### Response: C[C@]1(c2cc(F)ccc2F)NC(=O)N(C[C@H]2CCCCO2)C1=O
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC[C@H]1CCCN(C(=O)[C@H](C)NS(=O)(=O)c2ccc(OC)cc2)C1 ### Response: 3
functional_group
### Instruction: Does the molecule contain a phenol group? N#C[C@H]1COCCN1C(=O)[C@@H]1C[C@@H]1c1ccc(C(F)(F)F)cc1 ### Response: No
functional_group
### Instruction: Does the molecule contain a ether group? O=C1/C(=C\c2cc3ccccc3o2)SC(=S)N1c1ccc(F)cc1 ### Response: No
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)[C@H]1C=C(C)N=N1 Fragment 2: [6*]C(=O)c1cccc([16*])c1 ### Response: CC1=C[C@H](C(=O)N2CCC[C@H](C(=O)c3cccc(C(F)(F)F)c3)C2)N=N1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1ccc(O[C@H](C)C(=O)Nc2ccccc2Br)c(C)c1 ### Response: 3
functional_group
### Instruction: Does the molecule contain a nitrile group? CCOc1ccccc1[C@H]1C(C#N)=C(SC)NC2=C1C(=O)CCC2 ### Response: Yes
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Cn1nc(C(=O)N[C@H]2CC[C@H]([NH+](C)C)C2)ccc1=O ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. CC(C)N1C[C@@H](CC1=O)C(=O)Oc1cccc(C(F)(F)F)c1 ### Response: CC(C)N1C[C@H](C(=O)Oc2cccc(C(F)(F)F)c2)CC1=O
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? CC(=O)N1CCC(C(=O)Nc2sc(C)c(-c3ccccc3)c2C#N)CC1 ### Response: Yes
ring_counting
### Instruction: Count the six-membered rings in the following molecule. C[C@@H]1CCC[NH+](C(C)(C)CNC(=O)NC2CCCCC2)C1 ### Response: 2
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CCC(CC)n1nccc1C(=O)N[C@@H](CO)c1ccco1 ### Response: 0
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CCOc1cc(/C=C2\SC(=N)NC2=O)cc(Br)c1OC ### Response: 1
functional_group
### Instruction: Does the molecule contain a halide group? O=C(NCc1ccccc1F)NC1CCN(C(=O)c2ccco2)CC1 ### Response: Yes
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CC(C)C1(CNC(=O)N(C)C[C@H](C)O)CC1 ### Response: 0
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCC1(CNC(=O)N2CCC(C(=O)Nc3ccc(C)cn3)CC2)CC1 ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC(=O)CCc1ccc(OC(=O)[C@@H]2C[C@@H]2C)cc1 ### Response: 4
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)CO[3*] Fragment 2: [5*]N([5*])CC ### Response: CCN(C(=O)COC(=O)c1cc(=O)c2ccccc2o1)[C@H]1CCS(=O)(=O)C1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COc1ccc(O[C@H](C)C(=O)Nc2sc3c(c2C#N)CCC3)cc1 ### Response: 3
canonicalization
### Instruction: Canonicalize the following SMILES string. c1cccc(c1)[C@@H]1[C@@H](C[NH+]2[C@H]3CCCC[C@@H]3NC(=O)C2)C1 ### Response: O=C1C[NH+](C[C@H]2C[C@@H]2c2ccccc2)[C@H]2CCCC[C@@H]2N1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. C[C@@H](SCCOc1cccc(Cl)c1)C(N)=O ### Response: 0
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCC(CC)(CC)NC(=O)N[C@@H](C)CSC ### Response: 5
functional_group
### Instruction: Does the molecule contain a phenol group? CC(=O)N[C@H]1CCCN(C(=O)c2ccccc2OCc2ccccc2Cl)C1 ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. N([C@H](c1cc(c(cc1)Cl)F)CO)C(=O)Nc1cnccc1 ### Response: O=C(Nc1cccnc1)N[C@@H](CO)c1ccc(Cl)c(F)c1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1c(N2CCOCC2)ccc(c1)C[NH+]1CCS[C@H](C)[C@H]1C ### Response: C[C@@H]1[C@@H](C)SCC[NH+]1Cc1ccc(N2CCOCC2)cc1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)c1ccc(C)c(C)c1 Fragment 2: [5*]N1CCCc2cc(C)ccc21 ### Response: Cc1ccc2c(c1)CCCN2C(=O)c1ccc(C)c(C)c1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]NS(=O)(=O)c1ccc(C)cc1F Fragment 2: [5*]N1CCOCC1 ### Response: Cc1cccc([C@@H](CNS(=O)(=O)c2ccc(C)cc2F)N2CCOCC2)c1
functional_group
### Instruction: Does the molecule contain a sulfonyl group? CS(=O)(=O)/N=C(\[O-])CCCSc1ccccc1 ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N[C@H]([8*])C Fragment 2: [1*]C(=O)[C@H]([4*])C ### Response: Cc1nnc(S[C@H](C)C(=O)N[C@@H](C)c2ccc3c(c2)CCCC3)s1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CNC(=O)c1ccc(NC(=O)C[C@H](C)CC(C)C)cc1 ### Response: 6
canonicalization
### Instruction: Canonicalize the following SMILES string. c1c(cccc1C(Nc1ccccc1)=O)OC(c1ncn(-c2ccccc2)n1)=O ### Response: O=C(Nc1ccccc1)c1cccc(OC(=O)c2ncn(-c3ccccc3)n2)c1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1c(c(cc2c1nc(s2)NC(=O)CC(C)C)C)Cl ### Response: Cc1cc2sc(NC(=O)CC(C)C)nc2cc1Cl
functional_group
### Instruction: Does the molecule contain a ester group? CCOc1c(Cl)cc(/C=C/C(=O)c2ccc3c(c2)NC(=O)CO3)cc1OC ### Response: No
ring_counting
### Instruction: Count the five-membered rings in the following molecule. O=C([O-])C[C@@H]1COc2ccccc2N1Cc1ccccc1 ### Response: 0
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N[C@@H]([8*])c1ccccc1 Fragment 2: [16*]c1ccccc1 ### Response: O=C(CSc1nncs1)N[C@H](c1ccccc1)c1ccccn1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [7*]C1C(=O)NN([10*])C1=O Fragment 2: [7*]Cc1ccc(F)cc1 ### Response: Cc1ccc(N2NC(=O)/C(=C/c3ccc(F)cc3)C2=O)cc1C
canonicalization
### Instruction: Canonicalize the following SMILES string. C([NH2+]Cc1nc(C)sc1)c1ccc(c(c1)Cl)OCC=C ### Response: C=CCOc1ccc(C[NH2+]Cc2csc(C)n2)cc1Cl
ring_counting
### Instruction: Count the six-membered rings in the following molecule. COc1cccc(C[C@@H]2C[C@@H](C)CC[C@H]2O)n1 ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(ccc(cc1)[N+](=O)[O-])-c1csc(NC(c2c(cccc2)S(=O)(=O)C)=O)n1 ### Response: CS(=O)(=O)c1ccccc1C(=O)Nc1nc(-c2ccc([N+](=O)[O-])cc2)cs1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. OCCOc1cccc2cc[nH]c12 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [9*]n1ccc2nc3ncnn3c([14*])c2c1=O Fragment 2: [16*]c1ccccc1 ### Response: O=c1c2c(-c3ccccc3)n3ncnc3nc2ccn1-c1ccccn1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCC1(CC)[C@@H](Oc2cccnc2C)C[C@@H]1[O-] ### Response: 2
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Cc1cc(C)c(NC(=O)CNC(=O)c2ccc(Cl)c(Cl)c2)c(C)c1 ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)c1ccc2[nH]c3c(c2c1)CCCC3 Fragment 2: [5*]NCc1ccc(F)cc1 ### Response: O=C(NCc1ccc(F)cc1)c1ccc2[nH]c3c(c2c1)CCCC3
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1cc(C)c(C(=O)COc2cccc([N+](=O)[O-])c2C)cc1C ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCC[C@@H]1NC(=O)N(CC(=O)Nc2ccccc2Oc2ccccc2)C1=O ### Response: 3
functional_group
### Instruction: Does the molecule contain a thiol group? O=C(NCC[S@](=O)Cc1ccccc1)NCc1ccc(F)cc1 ### Response: No
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Cc1cccc([C@@H]2C[C@H](C(=O)NCc3ccccc3F)CN(C(=O)c3ccccc3)C2)c1 ### Response: 4
canonicalization
### Instruction: Canonicalize the following SMILES string. O=C(Nc1cc(ccc1)SC)C(=O)NCc1nncn1C1CC1 ### Response: CSc1cccc(NC(=O)C(=O)NCc2nncn2C2CC2)c1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? NC(=O)C1CC[NH+](CC(=O)Nc2ncc(Cc3ccccc3Cl)s2)CC1 ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]CC([6*])=O Fragment 2: [16*]c1ccc(OC)cc1OC ### Response: COc1ccc(C(=O)COc2ncnc3c(Cl)cc(Cl)cc23)c(OC)c1
functional_group
### Instruction: Does the molecule contain a hydroxyl group? Cc1ccc(N2CC[NH2+][C@H](C)C2)c(C)n1 ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. O(C)c1ccc2c([C@H]([C@@H](CC2)[NH+](CC)CC)NCC)c1 ### Response: CCN[C@@H]1c2cc(OC)ccc2CC[C@H]1[NH+](CC)CC
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N1CCCC1 Fragment 2: [13*][C@H]1NC(=O)c2ccccc2N1 ### Response: O=C1N[C@H](c2ccc(N3CCCC3)c([N+](=O)[O-])c2)Nc2ccccc21
canonicalization
### Instruction: Canonicalize the following SMILES string. C(/C(=O)Nc1ccc(cc1)C)=C1\SC(=O)N(CC(Nc2cc(ccc2)C)=O)C1=O ### Response: Cc1ccc(NC(=O)/C=C2/SC(=O)N(CC(=O)Nc3cccc(C)c3)C2=O)cc1
canonicalization
### Instruction: Canonicalize the following SMILES string. O1CCOc2ccc(S(/N=C(\[O-])c3cc(ccc3C)F)(=O)=O)cc21 ### Response: Cc1ccc(F)cc1/C([O-])=N/S(=O)(=O)c1ccc2c(c1)OCCO2
canonicalization
### Instruction: Canonicalize the following SMILES string. [O-][N+](=O)c1cnc(O[C@H]2C[C@@H](CCC2)[NH3+])cc1 ### Response: [NH3+][C@@H]1CCC[C@@H](Oc2ccc([N+](=O)[O-])cn2)C1
canonicalization
### Instruction: Canonicalize the following SMILES string. C(CSc1nnc(Cc2cccs2)n1C1CC1)(=O)Nc1ccc2CCCc2c1 ### Response: O=C(CSc1nnc(Cc2cccs2)n1C1CC1)Nc1ccc2c(c1)CCC2
canonicalization
### Instruction: Canonicalize the following SMILES string. N(CCN(CC#C)[C@@H]1CCS(=O)(=O)C1)(C)c1ccccc1 ### Response: C#CCN(CCN(C)c1ccccc1)[C@@H]1CCS(=O)(=O)C1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1cccc2c1c(c[nH]2)C[C@@H](C(=O)OC)NS(c1c2nonc2ccc1)(=O)=O ### Response: COC(=O)[C@H](Cc1c[nH]c2ccccc12)NS(=O)(=O)c1cccc2nonc12
canonicalization
### Instruction: Canonicalize the following SMILES string. S(=O)(NCCc1n(cnn1)CC)(c1c(C)cc(C)cc1)=O ### Response: CCn1cnnc1CCNS(=O)(=O)c1ccc(C)cc1C
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)c1csc(C#CCN)c1 Fragment 2: [5*]NCc1cccc(C#N)c1 ### Response: N#Cc1cccc(CNC(=O)c2csc(C#CCN)c2)c1
functional_group
### Instruction: Does the molecule contain a ketone group? O=C(c1ccc(F)cc1)N1CCN(c2ccc([N+](=O)[O-])c(NC[C@@H]3CCCO3)c2)CC1 ### Response: No
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? COc1ccc(CC(=O)N2CC[C@H]3[C@H](CCCN3C(=O)C3=CCCCC3)C2)cc1 ### Response: Yes