task
stringclasses
5 values
input
stringlengths
89
339
canonicalization
### Instruction: Canonicalize the following SMILES string. c1c(cc(-c2[nH]c(c3sccc3n2)=O)cc1)-c1nc(C)sc1 ### Response: Cc1nc(-c2cccc(-c3nc4ccsc4c(=O)[nH]3)c2)cs1
canonicalization
### Instruction: Canonicalize the following SMILES string. C(N[C@@H]1C[C@@](C1(C)C)(OC)C)(COCCC)=O ### Response: CCCOCC(=O)N[C@@H]1C[C@](C)(OC)C1(C)C
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=c1[nH]c(CSc2nnnn2C2CCCC2)nc2sc3c(c12)CCCC3 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1cc(N(C)C)ccc1[C@@H](CNC(=O)C(=O)Nc1cc(Cl)ccc1C#N)[NH+](C)C ### Response: CN(C)c1ccc([C@@H](CNC(=O)C(=O)Nc2cc(Cl)ccc2C#N)[NH+](C)C)cc1
functional_group
### Instruction: Does the molecule contain a halide group? [NH3+]C[C@H]1CC[C@@H](C(=O)N(C[C@@H]2CCCO2)[C@H]2CCSC2)O1 ### Response: No
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [7*]CC(F)(C(F)(F)F)C(F)(F)F Fragment 2: [7*]CC(=O)[O-] ### Response: O=C([O-])/C=C\C(F)(C(F)(F)F)C(F)(F)F
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CCCC[C@@H]1C[C@@H]1C(=O)Nc1ncc2c(n1)CC(C)(C)CC2=O ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C([O-])Cc1ccc(-c2cccc(F)c2F)cc1 ### Response: 2
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CCc1cc(N[C@H](C)C(=O)N2CCOCC2)nc(-c2ccccn2)n1 ### Response: 3
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(c(Cl)cc(cc1)NC(C1CCN(CC1)S(=O)(=O)c1ccc(F)cc1)=O)Cl ### Response: O=C(Nc1ccc(Cl)c(Cl)c1)C1CCN(S(=O)(=O)c2ccc(F)cc2)CC1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC(=O)Nc1cccc(NC(=O)CCc2c(C)[nH]c(=S)[nH]c2=O)c1 ### Response: 3
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? CC[NH2+]C[C@H](Cc1cscn1)c1cccc(F)c1 ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [16*]c1ccccc1F Fragment 2: [4*][C@@H](C)c1ccccc1F ### Response: CCNC(=O)COc1cccc(NC(=O)N(C)[C@@H](C)c2ccccc2F)c1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@H](Oc1ccccc1)C(=O)NC[C@@H](c1ccccc1)[NH+](C)C ### Response: 3
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Nc1ccc(Oc2nc3ccccc3n3cnnc23)cc1 ### Response: 3
functional_group
### Instruction: Does the molecule contain a amide group? C=C[C@@H](C)NC(=O)Nc1ccc2c(c1)COC2 ### Response: Yes
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CC[C@H](C(=O)NCc1ccc(C(=O)[O-])o1)c1ccccc1 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1c([N+](=O)[O-])cc(cc1)[C@@H](Oc1ccc(S(=O)(=O)C)cc1)C ### Response: C[C@H](Oc1ccc(S(C)(=O)=O)cc1)c1cccc([N+](=O)[O-])c1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCOCCCNC(=O)C(=O)Nc1cccc2c1CCCC2 ### Response: 3
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [3*]OCC Fragment 2: [1*]C(=O)C([1*])=O ### Response: CCOCc1ccc(NC(=O)C(=O)NC[C@H](C)C#N)cc1
functional_group
### Instruction: Does the molecule contain a ether group? NC(=O)c1nc(-c2ccccc2Cl)nc2c1[nH]c(=O)n2-c1ccc(Cl)cc1 ### Response: No
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CCc1nc2ccccc2n1C1CCN(c2ccnc(Cl)c2)CC1 ### Response: 3
functional_group
### Instruction: Does the molecule contain a halide group? Cc1sc(NC(=O)c2cc(Br)cs2)c(C#N)c1C ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1ccc(S(=O)(=O)CCC(=O)Nc2ccc(-c3nc4ccccc4o3)cc2)cc1 ### Response: 3
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)N1CCN([5*])CC1 Fragment 2: [16*]c1ccc(F)cc1 ### Response: O=C(Nc1ccc(Cl)cc1F)N1CCN(c2ccc(F)cc2)CC1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]Cc1nc(C)cs1 Fragment 2: [5*]N([5*])CC ### Response: CCN(CC(N)=S)Cc1nc(C)cs1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)N[C@@H]1CCCn2c(C)nnc21 Fragment 2: [5*][NH+](C)C1CCCCC1 ### Response: Cc1nnc2n1CCC[C@H]2NC(=O)NCCC[NH+](C)C1CCCCC1
canonicalization
### Instruction: Canonicalize the following SMILES string. S(=O)(=O)(C)c1ccc(NC(N2C[C@@H]([C@@H](O)C2)N2CCOCC2)=O)cc1 ### Response: CS(=O)(=O)c1ccc(NC(=O)N2C[C@H](O)[C@@H](N3CCOCC3)C2)cc1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1ccc2c(c1)C(=O)C(=O)N2C(C)C ### Response: 3
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Cc1nc(N2CCOCC2)c2c(C(=O)N3CCc4ccccc43)c(C)oc2n1 ### Response: 3
canonicalization
### Instruction: Canonicalize the following SMILES string. [C@@H](Sc1sc(NC2CC2)nn1)(C(=O)Nc1cc(c(cc1)F)Cl)C ### Response: C[C@H](Sc1nnc(NC2CC2)s1)C(=O)Nc1ccc(F)c(Cl)c1
canonicalization
### Instruction: Canonicalize the following SMILES string. C12S(NCNC=2N(C[NH+](C)C1)C)(=O)=O ### Response: CN1C[NH+](C)CC2=C1NCNS2(=O)=O
functional_group
### Instruction: Does the molecule contain a ether group? Cc1nc(NC(=O)/C=C/c2cc(Br)ccc2F)sc1C ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. c1cc2ccccc2c2C3=C([C@H](c4ccc(cc4)N(CC)CC)Nc21)C(CC3)=O ### Response: CCN(CC)c1ccc([C@@H]2Nc3ccc4ccccc4c3C3=C2C(=O)CC3)cc1
functional_group
### Instruction: Does the molecule contain a carboxyl group? CCCOc1ccc(C(=O)CCC(F)(F)F)cc1 ### Response: No
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COc1cc(C(=O)OCC(=O)Nc2cccc(C(C)=O)c2)ccc1C ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. O=[N+](c1c(NCc2ccc(nc2)N2CC[NH+](CC2)C)ccc(C(=O)C)c1)[O-] ### Response: CC(=O)c1ccc(NCc2ccc(N3CC[NH+](C)CC3)nc2)c([N+](=O)[O-])c1
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? OC1CCC([NH2+][C@H]2CCCc3ccc(Br)cc32)CC1 ### Response: Yes
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CNC(=O)[C@@H](C)CN(C)C(=O)C[C@@H]1CCS(=O)(=O)C1 ### Response: 0
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1cccc(C)c1NC(=O)Nc1ccc(N2CCCC2)c(C(=O)N[C@H](C)c2ccccc2)c1 ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [9*]n1cnnn1 Fragment 2: [5*]N[C@H]1CCCC[C@@H]1C ### Response: Cc1ccc(NC(=O)C(=O)N[C@H]2CCCC[C@@H]2C)cc1-n1cnnn1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CC(C)CC[NH+]1CCN(C(=O)c2nc(C3CC3)n[n-]2)CC1 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(C)c(c(nn1-c1sc2ccc(c(c2n1)Cl)Cl)C)C(=O)NN ### Response: Cc1nn(-c2nc3c(Cl)c(Cl)ccc3s2)c(C)c1C(=O)NN
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C([C@H]1CSCN1C(=O)c1ccc(-n2ccnn2)cc1)N1CCCC1 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C#CCN(C(=O)[C@@H]1SCCc2sccc21)[C@H]1CCS(=O)(=O)C1 ### Response: 3
functional_group
### Instruction: Does the molecule contain a sulfonyl group? CCC(CC)/C([O-])=N/S(=O)(=O)c1cc(C)c(C)c([N+](=O)[O-])c1 ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. c1ccc(c(CN(C2CCCC2)Cc2cnc3n2cccn3)c1F)F ### Response: Fc1cccc(F)c1CN(Cc1cnc2ncccn12)C1CCCC1
canonicalization
### Instruction: Canonicalize the following SMILES string. n1c(NC(C2CCN(C(Cc3ccccc3)=O)CC2)=O)scc1 ### Response: O=C(Nc1nccs1)C1CCN(C(=O)Cc2ccccc2)CC1
canonicalization
### Instruction: Canonicalize the following SMILES string. c12ccccc1[nH]cc2C(NCc1nc(OCC(F)F)ccc1)=O ### Response: O=C(NCc1cccc(OCC(F)F)n1)c1c[nH]c2ccccc12
canonicalization
### Instruction: Canonicalize the following SMILES string. n1c(n(nc1C(C)C)C)NC(=O)c1c(cn[nH]1)Br ### Response: CC(C)c1nc(NC(=O)c2[nH]ncc2Br)n(C)n1
functional_group
### Instruction: Does the molecule contain a nitrile group? O=C(CN1C(=O)CCc2cc(Br)ccc21)NCCN1CCc2ccccc2C1 ### Response: No
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@H]1OCC[C@H]1C(=O)Nc1cc[nH+]cc1[O-] ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]Nc1ncccc1S(N)(=O)=O Fragment 2: [16*]c1ccccc1 ### Response: NS(=O)(=O)c1cccnc1NCc1[nH]c(-c2ccccc2)c[nH+]1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. [NH3+][C@H]1C[C@H](n2ccc(=O)[nH]c2=O)O[C@@H]1COCc1ccccc1 ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. O(C)C(C1C(C)=NC2CC(CC(C=2[C@H]1c1cc(c(OC)c(OC)c1)OC)=O)(C)C)=O ### Response: COC(=O)C1C(C)=NC2=C(C(=O)CC(C)(C)C2)[C@H]1c1cc(OC)c(OC)c(OC)c1
canonicalization
### Instruction: Canonicalize the following SMILES string. [C@@H](NC(=O)C1CCOCC1)(C(=O)N)[C@@H](C)CC ### Response: CC[C@H](C)[C@H](NC(=O)C1CCOCC1)C(N)=O
ring_counting
### Instruction: Count the five-membered rings in the following molecule. O=C(Nc1cc(S(=O)(=O)N2CCCCCC2)ccc1OCC(F)(F)F)c1cccc2cn[nH]c12 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. [C@@H](C)(CN(C(=O)Nc1nccs1)C(C)C)O ### Response: CC(C)N(C[C@@H](C)O)C(=O)Nc1nccs1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COCC[C@](C)(O)C1(C[NH3+])CCC(C)(C)CC1 ### Response: 4
functional_group
### Instruction: Does the molecule contain a thiol group? N#C/C(=C/c1ccc(-c2cccc(Cl)c2Cl)o1)C(N)=O ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. n1c(n[n-]c1C(F)(F)F)NC(c1c(Cl)cccc1)=O ### Response: O=C(Nc1n[n-]c(C(F)(F)F)n1)c1ccccc1Cl
canonicalization
### Instruction: Canonicalize the following SMILES string. O[C@@H](Cn1cnc([N+](=O)[O-])c1)COc1cccc(C(=O)C)c1 ### Response: CC(=O)c1cccc(OC[C@@H](O)Cn2cnc([N+](=O)[O-])c2)c1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1cc(cc(c1F)N1CC(C1)CCC)C(=O)[O-] ### Response: CCCC1CN(c2cc(C(=O)[O-])ccc2F)C1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CCOC(=O)c1c(N/C=C2/C(=O)N(c3ccccc3)N=C2C)sc2c1CC[C@H](C)C2 ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]CC[NH+]([5*])C Fragment 2: [3*]OCC[NH+]([5*])C ### Response: CC(C)[NH+](C)CCOCC[NH3+]
functional_group
### Instruction: Does the molecule contain a ester group? COC(=O)c1ccc(C(=O)NCCc2cc(C)ccc2OC)cn1 ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. CC(n1c(nnc1N(C)C)S[C@H](C(=O)Nc1cc(C#N)ccc1)C)C ### Response: CC(C)n1c(S[C@@H](C)C(=O)Nc2cccc(C#N)c2)nnc1N(C)C
functional_group
### Instruction: Does the molecule contain a ether group? [NH3+][C@@H](CC[C@@H]1CCCO1)c1ccc(Cl)c2ccccc12 ### Response: Yes
functional_group
### Instruction: Does the molecule contain a amide group? CCC[NH2+]C1C[C@H]2CCC[C@@H](C1)N2CCC(=O)NC1CC1 ### Response: Yes
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CC(C)OCC[NH+]1CCC[C@@H]1[C@@H]1CCCC1=O ### Response: 2
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Cc1cc(C)n(CC(=O)N2CCC(n3c(C4CCC4)nc4cc(F)ccc43)CC2)n1 ### Response: 2
ring_counting
### Instruction: Count the five-membered rings in the following molecule. NC(=O)c1ccc(NC(=O)NCc2ccc3c(c2)CCC3)cc1 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCSc1ccccc1OC(=O)Cc1csc(-c2ccoc2)n1 ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. C([NH+]1C[C@@H]([C@@H](N[C@@H](C)CO)C1)C)(C)C ### Response: CC(C)[NH+]1C[C@H](N[C@@H](C)CO)[C@@H](C)C1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCOC(C(=O)NN1CCCCC1)(c1ccccc1)c1ccccc1 ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. c1sc([C@@H](NC(c2c(NCCC)cc(C)cc2)=O)C)nc1 ### Response: CCCNc1cc(C)ccc1C(=O)N[C@@H](C)c1nccs1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C/[NH+]=C(/NCCc1ncc(C)s1)N[C@@H]1C[C@@H](C)N(c2ccccc2)C1 ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C=C[C@H](C)NC(=O)Nc1ccc(COc2ccccc2)cc1 ### Response: 4
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [6*]C(=O)N/N=C1/C(=O)N(CN2CCCC2)c2ccc(Br)cc21 Fragment 2: [16*]c1ccc(OC)cc1 ### Response: COc1ccc(C(=O)N/N=C2/C(=O)N(CN3CCCC3)c3ccc(Br)cc32)cc1
functional_group
### Instruction: Does the molecule contain a halide group? O=C(NCCc1ccccc1)c1cccc(-c2ccc(S(=O)(=O)N3CCCC3)cc2)c1 ### Response: No
functional_group
### Instruction: Does the molecule contain a hydroxyl group? CC(C)[NH+]1CCC(C(=O)NC[C@H](O)c2cccc(C(F)(F)F)c2)CC1 ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COc1cccc(N2CCN(c3nn(-c4ccccc4)nc3C#N)CC2)c1 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*][C@@H](C)c1ccc(C)c(F)c1 Fragment 2: [5*]N[C@H]([8*])C ### Response: Cc1ccc([C@H](C)NC(=O)NCC(=O)Nc2cccnc2)cc1F
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [16*]c1cc2ccccc2cc1O Fragment 2: [6*]C(=O)N/N=C(\CC)c1ccc(O)cc1 ### Response: CC/C(=N\NC(=O)c1cc2ccccc2cc1O)c1ccc(O)cc1
functional_group
### Instruction: Does the molecule contain a amide group? O=C([O-])CCCCCN1C(=O)[C@@H]2CC=CC[C@H]2C1=O ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1ccc2nc(SCC(=O)Nc3cccc4c([O-])n[nH]c(=O)c34)[nH]c2c1 ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. c1c2ccccc2ccc1C(N1CCN(S(=O)(c2cc(F)ccc2)=O)CC1)=O ### Response: O=C(c1ccc2ccccc2c1)N1CCN(S(=O)(=O)c2cccc(F)c2)CC1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1noc(NC(=O)CCOC(C)C)n1 ### Response: 3
canonicalization
### Instruction: Canonicalize the following SMILES string. O(c1ccccc1OC)CCNC(Cn1c(=O)c2ccccc2s1)=O ### Response: COc1ccccc1OCCNC(=O)Cn1sc2ccccc2c1=O
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)C[4*] Fragment 2: [5*]Nc1cccc(Cl)c1C ### Response: Cc1c(Cl)cccc1NC(=O)CSc1nnc2nc([O-])c(C(C)(C)C)nn12
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]Cc1ccccc1OC Fragment 2: [5*]NC(=S)NC ### Response: CNC(=S)NC1C[C@H]2CCC[C@@H](C1)[NH+]2Cc1ccccc1OC
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? Cc1ccc2c(c1)c(CNC(=O)c1occc1C)nn2C ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCC(=O)N1CCN(CCc2nc(-c3ccccc3)no2)CC1 ### Response: 3
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1cc(C(=O)NC(C)(C)c2ccc([N+](=O)[O-])cc2)c2c(C)nn(C)c2n1 ### Response: 3
canonicalization
### Instruction: Canonicalize the following SMILES string. C(C(=O)N1[C@H](C)CCC1)C[NH+](C)C[C@@H](CN1CCOCC1)O ### Response: C[C@@H]1CCCN1C(=O)CC[NH+](C)C[C@H](O)CN1CCOCC1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [8*]C[C@@H]([8*])[NH3+] Fragment 2: [16*]c1ccccc1 ### Response: CC1(C)CCN(c2nc(C[C@H]([NH3+])c3ccccc3)cs2)C1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCS(=O)(=O)CCn1ccc(N[C@@H](C)c2cccc(Cl)c2)n1 ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [3*]OC(F)F Fragment 2: [4*]Cc1nnc2n1CCCCC2 ### Response: COc1cccc(CNCc2nnc3n2CCCCC3)c1OC(F)F
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@H](CNC(=O)C(=O)Nc1ccc(-n2cncn2)cc1)Oc1ccccc1 ### Response: 3
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]Cc1cccc(Cl)c1Cl Fragment 2: [5*]NCc1csc([14*])n1 ### Response: CN(C)c1nc(CNCc2cccc(Cl)c2Cl)cs1