task
stringclasses
5 values
input
stringlengths
89
339
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Cc1ccc(C(=O)NCc2cccc(S(N)(=O)=O)c2)n1C ### Response: 1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. COc1ccc(-c2nc(CN3CCNC(=O)C3)c(C)o2)c2ccccc12 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)c1c(N)n(C[8*])c2nc3ccccc3nc12 Fragment 2: [8*]Cc1ccc2c(c1)OCO2 ### Response: CC(C)COC(=O)c1c(N)n(Cc2ccc3c(c2)OCO3)c2nc3ccccc3nc12
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)C1([15*])CC1 Fragment 2: [5*]N[C@H]([8*])CC(C)C ### Response: CC(C)C[C@H](NC(=O)C1(c2ccccc2)CC1)c1nc2ccccc2[nH]1
functional_group
### Instruction: Does the molecule contain a halide group? CC(C)(C)OC(=O)N1CC[C@H](c2nc(Cc3ccc(F)cc3)no2)C1 ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [14*]c1nc2ccc(OC)cc2s1 Fragment 2: [5*]Nc1nc2ccc(OC)cc2s1 ### Response: COc1ccc2nc(Nc3ccc4c(c3)CCC4)sc2c1
functional_group
### Instruction: Does the molecule contain a nitro group? O=c1nnc(-c2ccc([N+](=O)[O-])o2)c([O-])[nH]1 ### Response: Yes
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CCN(C(=O)C1CC=CC1)c1ccc(F)c(F)c1 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1noc(C)c1COc1ccc(CN2CCO[C@H](c3ccsc3)C2)cc1 ### Response: 1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CC[C@H](C)NC(=O)N1CCc2cc(OC)c(OC)cc2[C@H]1c1ccccc1 ### Response: 3
canonicalization
### Instruction: Canonicalize the following SMILES string. C1C[NH+](C2CC2)C[C@@H]1CNC(c1cc(ncc1)OC(C)(C)C)=O ### Response: CC(C)(C)Oc1cc(C(=O)NC[C@@H]2CC[NH+](C3CC3)C2)ccn1
functional_group
### Instruction: Does the molecule contain a ester group? O=C(Nc1ccc2c(c1)OCO2)c1nn(C23CC4CC(CC(C4)C2)C3)cc1[N+](=O)[O-] ### Response: No
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [8*]C(F)(F)F Fragment 2: [8*]CCC ### Response: CCCc1noc(CNc2ccccc2C(F)(F)F)n1
functional_group
### Instruction: Does the molecule contain a halide group? Cc1nnc([C@H]2Cc3ccccc3CN2Cc2ccc(Cl)c(F)c2)o1 ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [16*]c1cc(Cl)sc1Cl Fragment 2: [8*]C(C)(C)CCO ### Response: CC(C)(CCO)c1cc(Cl)sc1Cl
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CC(C)n1c(N)c(C(=O)CCl)c(=O)[nH]c1=O ### Response: 0
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Cc1csc(Cn2c3c(sc2=O)C[C@@H](C)CC3)n1 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1ccc(Oc2ccc(cc2)C(=O)N([C@H]2CC(=NC2=O)[O-])C2CC2)cc1 ### Response: O=C1N=C([O-])C[C@@H]1N(C(=O)c1ccc(Oc2ccccc2)cc1)C1CC1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. COc1ccccc1CC(=O)NNC(=O)c1oc2ccc(Cl)cc2c1C ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. C1(/C(SC(=S)N1[C@H](C([O-])=O)CCC)=C\c1c2c(cccc2)n(C)c1)=O ### Response: CCC[C@@H](C(=O)[O-])N1C(=O)/C(=C\c2cn(C)c3ccccc23)SC1=S
ring_counting
### Instruction: Count the five-membered rings in the following molecule. O=C(c1[nH]nc2c1CN(C(=O)C1CC1)CC2)N1CCCCC1 ### Response: 1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CN(C(=O)NCc1ccc([N+]2=CCCC2)cc1)C1CCCCC1 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N1CCc2sccc2[C@@H]1c1cccs1 Fragment 2: [16*]c1ccc(F)cc1 ### Response: Cc1nc(C(=O)N2CCc3sccc3[C@@H]2c2cccs2)nn1-c1ccc(F)cc1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COCCNC(=O)c1cccc([N-]S(=O)(=O)c2cccc3cccnc23)c1 ### Response: 2
ring_counting
### Instruction: Count the six-membered rings in the following molecule. COC[C@@](C)(NC(=O)CCn1nc2ccccn2c1=O)c1ccccc1 ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. C1C(=O)C2[C@@]3(C(=C(N)OC=2CC1(C)C)C#N)C(=O)N1c2c([C@H](CC41CCCCC4)C)cccc23 ### Response: C[C@H]1CC2(CCCCC2)N2C(=O)[C@@]3(C(C#N)=C(N)OC4=C3C(=O)CC(C)(C)C4)c3cccc1c32
functional_group
### Instruction: Does the molecule contain a aldehyde group? CC[C@H](C)C(=O)Nc1ccccn1 ### Response: No
ring_counting
### Instruction: Count the six-membered rings in the following molecule. NC(=O)[C@@]1(Cc2ccccc2-c2cccnc2)CCN(C(=O)c2ccccn2)C1 ### Response: 3
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1cc(S(=O)(=O)/N=C(\[O-])[C@@H]2CCC[C@@H](C)C2)cc([N+](=O)[O-])c1C ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [9*]n1nccc1[14*] Fragment 2: [5*]N[C@@H]1CCN(C[8*])C1 ### Response: O=C(Nc1ccc(F)cc1)N[C@@H]1CCN(Cn2nccc2-c2ccncc2)C1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CN(CC(=O)Nc1ccc(Cl)c([N+](=O)[O-])c1)S(=O)(=O)c1ccccc1 ### Response: 0
functional_group
### Instruction: Does the molecule contain a nitrile group? CC(C)(C)c1nnc(NC(=O)NCc2cn(-c3ccccc3)nn2)s1 ### Response: No
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1c(C)n(C)c2ccc(C(=O)N3CCC[C@]4(CCC(=O)N4)[C@H]3c3cccc(F)c3)cc12 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCOc1cc(CNC(=O)Nc2nncs2)ccn1 ### Response: 2
functional_group
### Instruction: Does the molecule contain a sulfonyl group? O=C(CNC(=O)C1CCCC1)Nc1nc(C[NH+]2CCCCCC2)cs1 ### Response: No
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CC(C)N[C@]1(C#N)CC[C@H](n2cc[nH+]c2)C1 ### Response: 0
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [7*]C([8*])C#N Fragment 2: [14*]c1nc2cccnc2[n-]1 ### Response: Cn1cc(/C=C(/C#N)c2nc3cccnc3[n-]2)c(-c2ccncc2)n1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. O=C(NCCC1=c2ccccc2=[NH+]C1)c1ccc2c(c1)[C@H](c1ccccc1)ON2 ### Response: 3
canonicalization
### Instruction: Canonicalize the following SMILES string. [C@@H]1(C(=O)[O-])C2(CCCCC2)C[NH+](Cc2ccc(c(c2)Cl)Cl)C1 ### Response: O=C([O-])[C@H]1C[NH+](Cc2ccc(Cl)c(Cl)c2)CC12CCCCC2
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CC[NH+](CC)CCn1/c(=N/C(=O)C2CCCC2)[nH]c2ccccc21 ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@H](CNC(=O)[C@H]1CC[NH2+][C@@H]1C)C[NH+]1CCCC1 ### Response: 3
canonicalization
### Instruction: Canonicalize the following SMILES string. n1(c(c(cn1)C(=O)N(C)[C@H](C)c1ccon1)C1CC1)-c1nc2-c3c(CCc2cn1)ccc(OC)c3 ### Response: COc1ccc2c(c1)-c1nc(-n3ncc(C(=O)N(C)[C@H](C)c4ccon4)c3C3CC3)ncc1CC2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [15*]C12CC3C[C@@](C)(C1)C[C@](C)(C3)C2 Fragment 2: [8*]CCN[NH3+] ### Response: C[C@]12CC3CC(CCN[NH3+])(C1)C[C@@](C)(C3)C2
canonicalization
### Instruction: Canonicalize the following SMILES string. C1C[C@H](OC1)[C@@H](OC(c1ccc(c(OC(F)F)c1)OC)=O)C ### Response: COc1ccc(C(=O)O[C@@H](C)[C@@H]2CCCO2)cc1OC(F)F
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)c1ccc([16*])cc1 Fragment 2: [4*]Cc1cc(CC)no1 ### Response: CCc1cc(C[NH+]2CCC[C@H](CNC(=O)c3ccc(-c4ccccc4)cc3)C2)on1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*][N-]C#N Fragment 2: [6*]C(=O)[O-] ### Response: Cc1c(F)cc(C(=O)[O-])cc1S(=O)(=O)[N-]C#N
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1ccc(NC(=O)CSc2nc3ccccc3c(=O)n2Cc2ccco2)c([N+](=O)[O-])c1 ### Response: 2
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CCCc1c(C(=O)N2CCO[C@@H](CCC)C2)[nH]c(C)c1C(C)=O ### Response: 1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CS[C@H](C)C(=O)Oc1ccc(OCC2CC2)cc1 ### Response: 1
functional_group
### Instruction: Does the molecule contain a amide group? CCn1nc(C(F)(F)F)cc1CNc1cc(F)ccc1F ### Response: No
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1cc(N[C@H]2CCN(c3ccc(C#N)cc3)C2=O)ccc1C(=O)N(C)C ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [14*]c1cc([14*])on1 Fragment 2: [16*]c1cccc(OC)c1 ### Response: COc1cccc(-c2cc(CC(=O)NC(C)(C)C)no2)c1
canonicalization
### Instruction: Canonicalize the following SMILES string. N(C(=O)N[C@@](C)(C([O-])=O)C(F)(F)F)[C@@H](C(C)C)C[NH+](C)C ### Response: CC(C)[C@@H](C[NH+](C)C)NC(=O)N[C@@](C)(C(=O)[O-])C(F)(F)F
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C1COc2cc(OCc3c(F)cccc3Cl)ccc21 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CSCC[C@@H](C)NC(=O)C(=O)Nc1cc(C)ccc1C ### Response: 4
functional_group
### Instruction: Does the molecule contain a halide group? CCc1ccc([C@@H](COC)NC(=O)C(=O)Nc2cccc(F)c2C)o1 ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1cccc(OC(=O)CCn2c(C)csc2=O)c1C ### Response: 3
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1ccc(S(=O)(=O)N2CCC(C(=O)O[C@@H](C)C(=O)Nc3ccc4c(c3)OCO4)CC2)c(C)c1 ### Response: 3
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? CCN(C)c1cccc(NC(=O)Cn2nnc3ccccc32)c1 ### Response: Yes
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? CN(CCc1cccs1)C(=O)c1ccc(-n2ccnc2)c([N+](=O)[O-])c1 ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. C(c1sc([C@@H]([NH2+][C@H]2[C@H]3[C@H](OCC3)C2(C)C)C)c(C)n1)COC ### Response: COCCc1nc(C)c([C@H](C)[NH2+][C@H]2[C@@H]3CCO[C@@H]3C2(C)C)s1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N(C)C[8*] Fragment 2: [1*]C(=O)[C@H]1CC(=O)N([10*])C1 ### Response: CN(Cc1cccc([N+](=O)[O-])c1)C(=O)[C@H]1CC(=O)N(c2cccc3ccccc23)C1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [11*]Sc1cccc([16*])c1 Fragment 2: [6*]C(C)=O ### Response: CC(=O)c1cccc(SCc2ccc([N+](=O)[O-])c(F)c2)c1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1ccc(N(CC(=O)NC[C@@H]2CCCO2)S(C)(=O)=O)cc1Cl ### Response: 2
ring_counting
### Instruction: Count the five-membered rings in the following molecule. O=C(C[C@H]1CCCCO1)c1ccc2ccccc2c1 ### Response: 0
functional_group
### Instruction: Does the molecule contain a nitrile group? COc1ccc([N+](=O)[O-])c(C(=O)Nc2ccc(C)cc2OCc2ccccc2)c1 ### Response: No
functional_group
### Instruction: Does the molecule contain a amide group? COc1ccc(C(=O)N2CCC(CN3CCCC3=O)CC2)c(OC)n1 ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [8*]Cc1ccccn1 Fragment 2: [5*]NCc1nncn1CC ### Response: CCn1cnnc1CNC(=O)[C@@H]1CC(=O)N(Cc2ccccn2)C1
functional_group
### Instruction: Does the molecule contain a ester group? Cc1ccnc2c1nc(CCl)n2[C@H]1CCC[C@@H]1C ### Response: No
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C1CCCCN1CN1CC[C@H](C[NH+]2CCCC2)C1 ### Response: 1
functional_group
### Instruction: Does the molecule contain a amide group? O=C(N[C@@H]1CCCC[C@H]1C(F)(F)F)c1nccc2ccccc12 ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? c1cc(CN2CCCC[C@@H]2c2ccncn2)ccn1 ### Response: 1
functional_group
### Instruction: Does the molecule contain a phenol group? CN1N=C(C(=O)N2CCOC[C@@H]2C2CC2)CCC1=O ### Response: No
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Cc1c(C(=O)Nc2ccc(I)cc2)oc2c1C(=O)CC(C)(C)C2 ### Response: 2
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Nc1nccnc1C(=O)N1CCc2ccccc2C1 ### Response: 0
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [14*]c1cccs1 Fragment 2: [4*][C@H]([8*])CN[5*] ### Response: CN(C)[C@@H](CNC(=O)c1cn(-c2ccccc2)nc1-c1cccs1)c1cccs1
functional_group
### Instruction: Does the molecule contain a amide group? NC(=O)c1cccc2c1CCCN2C(=O)C1=NN(Cc2ccccc2)C(=O)CC1 ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. c1cccc2c1N1C(S2)=C([C@](c2ccccc2)(C(F)(F)F)NC1=O)C(=O)OCC ### Response: CCOC(=O)C1=C2Sc3ccccc3N2C(=O)N[C@@]1(c1ccccc1)C(F)(F)F
canonicalization
### Instruction: Canonicalize the following SMILES string. [nH+]1ccccc1NCCNC(c1cc(O)c(cc1)Br)=O ### Response: O=C(NCCNc1cccc[nH+]1)c1ccc(Br)c(O)c1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@@]1(Cc2ccc3c(c2)OCO3)NC(=O)N(C[C@H](O)c2ccc(Cl)cc2)C1=O ### Response: 2
ring_counting
### Instruction: Count the six-membered rings in the following molecule. COc1cccc(CCNC(=O)[C@H]2CCCN(C(=O)NC3CC3)C2)c1 ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@H]1CCC[NH+](CCNC(=O)NCc2ccc(Cl)nc2)C1 ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C=CCCCC(=O)Oc1ccccc1F ### Response: 6
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@@H](CO)[C@@H](C)NC(=O)C(=O)Nc1cnc(-c2ccccc2)s1 ### Response: 4
canonicalization
### Instruction: Canonicalize the following SMILES string. C1C[C@@]([NH2+]CC)(C[C@H](C1)Oc1ccc(cc1)CCC)CO ### Response: CCCc1ccc(O[C@H]2CCC[C@@](CO)([NH2+]CC)C2)cc1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1occc1C(=O)NC[C@@H](O)c1ccc(F)cc1 ### Response: 2
functional_group
### Instruction: Does the molecule contain a amine group? Cc1sc2nc(CN3CCC[C@@H](C(=O)NCC4CC4)C3)nc(N)c2c1C ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. [C@]1(C)(CNC(=O)N[C@@H](C2CCCCC2)C(=O)[O-])OCCC1 ### Response: C[C@]1(CNC(=O)N[C@H](C(=O)[O-])C2CCCCC2)CCCO1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]NC[C@H]1CN2CCCC[C@@H]2CO1 Fragment 2: [1*]C(=O)c1cccc(C)c1Cl ### Response: Cc1cccc(C(=O)NC[C@H]2CN3CCCC[C@@H]3CO2)c1Cl
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=[N+]([O-])c1cccc(NC(=S)Nc2ccc(F)c(F)c2)c1 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1c(C)c(C(=O)N[C@@H]2[C@H](C)CCCC2)ccc1 ### Response: Cc1ccccc1C(=O)N[C@H]1CCCC[C@H]1C
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [14*]c1nnc([14*])o1 Fragment 2: [15*][C@H]1CCO[C@H]1C ### Response: C[C@@H]1OCC[C@@H]1c1nnc(-c2cccc(C(=O)[O-])c2)o1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [8*]C(C)(C)C Fragment 2: [15*][C@H]1CCCCC[C@@H]1[NH3+] ### Response: CC(C)(C)c1ccc2oc([C@H]3CCCCC[C@@H]3[NH3+])nc2c1
canonicalization
### Instruction: Canonicalize the following SMILES string. Cc1noc(c1COc1ccc(cc1)C[NH+]1CCCC[C@@H](C1)SC)C ### Response: CS[C@H]1CCCC[NH+](Cc2ccc(OCc3c(C)noc3C)cc2)C1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. C[C@@H]1COC[C@@H](C)N1CC(=O)NC1(C#N)CCCCC1 ### Response: 0
canonicalization
### Instruction: Canonicalize the following SMILES string. c1c(nccc1C#N)N1CCC([NH2+]C[C@@H]2CCCO2)CC1 ### Response: N#Cc1ccnc(N2CCC([NH2+]C[C@@H]3CCCO3)CC2)c1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. COC(=O)[C@H](C)Oc1ccc(Cl)cc1C ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COC(=O)c1c(NC(=O)c2cccc(F)c2)sc(C(=O)NC(C)C)c1C ### Response: 3
canonicalization
### Instruction: Canonicalize the following SMILES string. O=C(C[NH+]1[C@H]2CCCC[C@@H]2CCC1)N(CCCC)[C@H]1CS(CC1)(=O)=O ### Response: CCCCN(C(=O)C[NH+]1CCC[C@H]2CCCC[C@@H]21)[C@@H]1CCS(=O)(=O)C1
canonicalization
### Instruction: Canonicalize the following SMILES string. C[C@@H]1C[C@H](CC(CC[NH+]2CCN(CC2)CC(NC(C)C)=O)C1)C ### Response: CC(C)NC(=O)CN1CC[NH+](CCC2C[C@H](C)C[C@@H](C)C2)CC1