task
stringclasses
5 values
input
stringlengths
89
339
canonicalization
### Instruction: Canonicalize the following SMILES string. C(N[C@@H](CC)C(C)(C)c1ccccc1)(NCc1c(nn(c1)C)CC)=O ### Response: CCc1nn(C)cc1CNC(=O)N[C@@H](CC)C(C)(C)c1ccccc1
canonicalization
### Instruction: Canonicalize the following SMILES string. C(O)[C@](C1CCCCC1)([NH2+]CC(=O)N(CC)[C@@H]1CCS(=O)(C1)=O)C ### Response: CCN(C(=O)C[NH2+][C@](C)(CO)C1CCCCC1)[C@@H]1CCS(=O)(=O)C1
functional_group
### Instruction: Does the molecule contain a thiol group? COc1cc(C)c(I)c(C)c1C#N ### Response: No
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CC1=NN(c2ccc(C(=O)Nc3cccnc3-n3cccn3)cc2)CC1 ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CS(=O)(=O)CC[C@H]([NH3+])C(=O)N[C@@H]1CONC1=O ### Response: 4
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? NC(=O)CN1CCN([C@H]2CC(=O)N(CCc3ccccc3)C2=O)CC1 ### Response: Yes
ring_counting
### Instruction: Count the five-membered rings in the following molecule. C[NH2+][C@H](C)c1ccn(CC(=O)NC(C)(C)C)c1 ### Response: 1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Cc1cc(C(=O)N2CCC[C@H](CCC(=O)NCc3ccc(F)c(F)c3)C2)nc(C)n1 ### Response: 3
functional_group
### Instruction: Does the molecule contain a nitrile group? CC(C)n1cc(C(=O)c2ccccc2OCC(=O)Nc2ccc(Cl)c(Cl)c2)cc(C#N)c1=O ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1noc2ncc(NC(=O)C=C3CN(C(=O)OC(C)(C)C)C3)cc12 ### Response: 3
canonicalization
### Instruction: Canonicalize the following SMILES string. CC(C)(CNC(N[C@@H](C)C(N1CCCC[C@H]1C)=O)=O)[NH+](C)C ### Response: C[C@H](NC(=O)NCC(C)(C)[NH+](C)C)C(=O)N1CCCC[C@H]1C
functional_group
### Instruction: Does the molecule contain a ester group? O=C(OCc1nnc(-c2ccc(Cl)cc2)o1)c1cccc(-n2cnnn2)c1 ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]Nc1nc([14*])nc(NN)n1 Fragment 2: [16*]c1cccc(Cl)c1 ### Response: NNc1nc(Nc2cccc(Cl)c2)nc(N2CCOCC2)n1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [3*]OCC[NH3+] Fragment 2: [4*]Cc1cc(F)cc(Br)c1 ### Response: [NH3+]CCOCc1cc(F)cc(Br)c1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [15*][C@H]1CC[C@@]([15*])([NH2+]C)C1 Fragment 2: [15*]C1CCCCC1 ### Response: C[NH2+][C@]1(C(=O)[O-])CC[C@H](SC2CCCCC2)C1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C(Cc1c(F)cccc1F)NC[C@H]1CC[C@H](C(=O)[O-])O1 ### Response: 2
functional_group
### Instruction: Does the molecule contain a nitro group? CC(C)n1cnnc1SCc1csc(-c2ccccc2F)n1 ### Response: No
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? COC(C)(C)C[C@H](C)NC(=O)Nc1ccc(-n2ncn(C)c2=O)cc1 ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. o1c(nc(n1)CCOC)-c1cc(ccc1)S(CC)(=O)=O ### Response: CCS(=O)(=O)c1cccc(-c2nc(CCOC)no2)c1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. C[C@@H](NC(=O)c1cc2c(s1)CS(=O)(=O)C2)C12CC3CC(CC(C3)C1)C2 ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCC[NH2+][C@H](C)c1cc(F)ccc1Oc1cccnc1C ### Response: 3
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [16*]c1ccc(C[NH3+])cc1 Fragment 2: [5*]N1C[C@@H](C)[C@H](C)C1 ### Response: C[C@@H]1CN(c2ccc(C[NH3+])cc2)C[C@H]1C
functional_group
### Instruction: Does the molecule contain a nitrile group? Cc1nc(N2CC[NH+](C)CC2)[nH]c(=O)c1CC#N ### Response: Yes
functional_group
### Instruction: Does the molecule contain a amide group? CCc1nnc(NC(=O)[C@H]2CC(=O)C(OCc3ccccc3)=CO2)s1 ### Response: Yes
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Cc1ccc(C(=O)Nc2ccc(-n3ncn(C)c3=O)cc2)c(C)n1 ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCOc1ccccc1NC(=O)C(=O)N[C@@H](C)C1CCCCC1 ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1c([C@H]2CCC[NH+]2Cc2cc(C(F)(F)F)ccc2F)cnn1C ### Response: 1
functional_group
### Instruction: Does the molecule contain a amine group? CCC[C@H](O)CNS(=O)(=O)N1CCCCCC1 ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CSCc1ccnc(NCc2[nH]c(-c3ccccc3)c[nH+]2)c1 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. CN(S(=O)(=O)c1cc(c(N2CCOCC2)cc1)C(=O)Nc1sc(nn1)C(C)C)C ### Response: CC(C)c1nnc(NC(=O)c2cc(S(=O)(=O)N(C)C)ccc2N2CCOCC2)s1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COC[C@H](C)N/C(N)=[NH+]/C[C@H]1CN2CCCC[C@@H]2CO1 ### Response: 3
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]CCC Fragment 2: [1*]C(=O)[C@H]([4*])C ### Response: CCC[NH+]1CCC(NC(=O)[C@@H](C)Sc2ccccc2Cl)CC1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCc1ccc([C@H](C)CC(=O)N(C)[C@@H](C)CS(C)(=O)=O)cc1 ### Response: 4
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)c1c([14*])noc1C Fragment 2: [5*]N1CCCC[C@@H]1[13*] ### Response: Cc1onc(-c2ccccc2Cl)c1C(=O)N1CCCC[C@@H]1C(=O)[O-]
ring_counting
### Instruction: Count the six-membered rings in the following molecule. COC(=O)[C@]1(CC(=O)N2CCOCC2)C(=O)C[C@H]2CC[C@@H]1N2Cc1ccc(F)cc1 ### Response: 3
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@@H]1CC[C@@](C#N)([C@](C)(O)C2(C)CC2)C1 ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C(COC(=O)C1CCN(C(=O)c2ccc(Cl)cc2)CC1)Nc1cccc(F)c1 ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. N1([C@@H](CCCC1)CO)S(c1c(cc(N)cc1C)C)(=O)=O ### Response: Cc1cc(N)cc(C)c1S(=O)(=O)N1CCCC[C@H]1CO
canonicalization
### Instruction: Canonicalize the following SMILES string. c1c(ccnc1)C(OCC(N1CC(=O)Nc2c1cccc2)=O)=O ### Response: O=C1CN(C(=O)COC(=O)c2ccncc2)c2ccccc2N1
functional_group
### Instruction: Does the molecule contain a halide group? CC[C@H](C)Cn1c(CCCl)nc2c(C)nn(C)c21 ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]CCS(=O)(=O)c1ccc(C#N)cc1 Fragment 2: [5*]N1CCCc2ccccc21 ### Response: N#Cc1ccc(S(=O)(=O)CCN2CCCc3ccccc32)cc1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COc1cccc(-c2csc(/C(C#N)=C\Nc3ccc(Cl)c(C(F)(F)F)c3)n2)c1 ### Response: 3
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(C(N(CC(C)C)CC(C)C)=O)cc2ccc(OC)cc2oc1=O ### Response: COc1ccc2cc(C(=O)N(CC(C)C)CC(C)C)c(=O)oc2c1
canonicalization
### Instruction: Canonicalize the following SMILES string. C1SC(CN(C1)C(=O)NCc1ccccc1C)(C)C ### Response: Cc1ccccc1CNC(=O)N1CCSC(C)(C)C1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CCNC(=O)[C@H]1CCCN(C(=O)C=C(C2CC2)C2CC2)C1 ### Response: 0
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)c1cccc([16*])c1 Fragment 2: [3*]OCC ### Response: CCOC(=O)c1cccc(NC2=C(Cl)C(=O)N(Cc3ccccc3)C2=O)c1
canonicalization
### Instruction: Canonicalize the following SMILES string. Clc1cc(C[S@]([C@@H](C(=O)NCC(C)C)C)=O)ccc1Cl ### Response: CC(C)CNC(=O)[C@@H](C)[S@](=O)Cc1ccc(Cl)c(Cl)c1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. O=C1C(=Cc2ccccc2I)C(=O)c2ccccc21 ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(C(=O)Nc2ccc(-n3ccnn3)cc2)c(C(C)(C)C)nn(c1)C ### Response: Cn1cc(C(=O)Nc2ccc(-n3ccnn3)cc2)c(C(C)(C)C)n1
canonicalization
### Instruction: Canonicalize the following SMILES string. [C@@H](NC[C@]1(CCCO1)C)(C[NH3+])c1cc(sc1C)C ### Response: Cc1cc([C@@H](C[NH3+])NC[C@@]2(C)CCCO2)c(C)s1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*][C@H](C)CSC Fragment 2: [5*]NS(=O)(=O)c1c(C)cc(C)cc1C ### Response: CSC[C@@H](C)NS(=O)(=O)c1c(C)cc(C)cc1C
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [16*]c1ccccc1C#N Fragment 2: [16*]c1ccccc1 ### Response: C[C@H]1C[C@H](NC(=O)COc2ccccc2C#N)CN1c1ccccc1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CCN1C(=O)C[C@@H]([NH3+])[C@@H]1c1ccccc1C1CC1 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)C[C@@H]1OC(=O)c2ccccc21 Fragment 2: [5*]NCc1ccccc1C ### Response: Cc1ccccc1CNC(=O)C[C@@H]1OC(=O)c2ccccc21
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1cc2nc(SCC(=O)[O-])n(CC(C)C)c(=O)c2[nH]1 ### Response: 3
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CC[NH2+][C@@]1(C(=O)[O-])CCC[C@@H](Sc2ncc(C)cn2)C1 ### Response: 2
ring_counting
### Instruction: Count the six-membered rings in the following molecule. COc1ccc(C[NH+]2CCN([C@@H](C)C(=O)NC3CCCC3)CC2)cc1SC ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(c(Cl)nccc1)S(=O)(NCC=C)=O ### Response: C=CCNS(=O)(=O)c1cccnc1Cl
functional_group
### Instruction: Does the molecule contain a ester group? O=C(C[C@@H]1CSc2nccc(=O)n21)Nc1ccccn1 ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. c1n(ncc1)S(c1cc(Cl)c(OC)cc1Cl)(=O)=O ### Response: COc1cc(Cl)c(S(=O)(=O)n2cccn2)cc1Cl
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1ccc(NC(=O)Cn2c(C)cc(C)c(C#N)c2=O)c(C)c1 ### Response: 2
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Cc1oc(-c2cccs2)nc1C[S@@](=O)CCO ### Response: 0
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CCC[NH2+]CC[NH+](C)CC(C)(C)O ### Response: 0
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)c1ccc(F)cc1 Fragment 2: [15*][C@H]1CC[C@@H](CC)C1 ### Response: CC[C@@H]1CC[C@H]([NH+]2CCN(C(=O)c3ccc(F)cc3)CC2)C1
functional_group
### Instruction: Does the molecule contain a nitro group? COc1ccc([C@H](C)NC(=O)Cc2ccc(C)cc2)cc1 ### Response: No
functional_group
### Instruction: Does the molecule contain a ketone group? [NH3+][C@H](Cc1cccc(O)c1)c1ccccn1 ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. O=C(NCC(C)(O)C)c1c(c([N+](=O)[O-])ccc1F)F ### Response: CC(C)(O)CNC(=O)c1c(F)ccc([N+](=O)[O-])c1F
canonicalization
### Instruction: Canonicalize the following SMILES string. FC(F)Oc1cccc(c1)C(=O)N1c2ccccc2O[C@@H](C(=O)OC)C1 ### Response: COC(=O)[C@H]1CN(C(=O)c2cccc(OC(F)F)c2)c2ccccc2O1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C=CCNC(=O)[C@H](C)SCc1ccc(-n2cccn2)cc1 ### Response: 3
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [8*]C(F)F Fragment 2: [14*]c1cc([16*])c2c(C)noc2n1 ### Response: CCn1cc(-c2cc(C(F)F)c3c(C)noc3n2)c(C)n1
functional_group
### Instruction: Does the molecule contain a aldehyde group? CC(C)OC(=O)N1CCC2(CC1)C[C@H](c1ccccc1)C(=O)N(C)C2 ### Response: No
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC(C)Oc1ccc(C(=O)NCc2ccc(S(N)(=O)=O)cc2)cc1 ### Response: 3
canonicalization
### Instruction: Canonicalize the following SMILES string. N1c2nc(SCc3c(Cl)cccc3)nn2[C@H](C(C(=O)OC)=C1C)c1ccncc1 ### Response: COC(=O)C1=C(C)Nc2nc(SCc3ccccc3Cl)nn2[C@H]1c1ccncc1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [12*]S(=O)(=O)c1c(F)cccc1Br Fragment 2: [5*]N1C[C@H]2CC[C@@H]1C2 ### Response: O=S(=O)(c1c(F)cccc1Br)N1C[C@H]2CC[C@@H]1C2
canonicalization
### Instruction: Canonicalize the following SMILES string. c1c(cccc1C(=O)NC[C@@H](C[C@@H](C)O)C)-c1cocc1 ### Response: C[C@@H](CNC(=O)c1cccc(-c2ccoc2)c1)C[C@@H](C)O
canonicalization
### Instruction: Canonicalize the following SMILES string. c1c(C)nc(nc1C)NNC(=O)[C@H]1CN(c2c(ccc(Cl)c2)OC)C(=O)C1 ### Response: COc1ccc(Cl)cc1N1C[C@H](C(=O)NNc2nc(C)cc(C)n2)CC1=O
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cn1cccc1[C@@H]1CCC[NH+]1CC(=O)Nc1sc2c(c1C(N)=O)CCC2 ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]CCn1c(C)c(C)n2c3c(=O)n(C)c(=O)n(C)c3nc12 Fragment 2: [5*]Nc1cc(OC)ccc1OC ### Response: COc1ccc(OC)c(NCCn2c(C)c(C)n3c4c(=O)n(C)c(=O)n(C)c4nc23)c1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cn1ncc2c(NNC(=O)c3cccc([N+](=O)[O-])c3)ncnc21 ### Response: 1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. O=C1C[C@@H](NC2=NS(=O)(=O)c3ccccc32)CN1CC(F)(F)F ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. O=S(=O)(c1cc(NC(c2c(ccc(Br)c2)F)=O)ccc1)NC1CC1 ### Response: O=C(Nc1cccc(S(=O)(=O)NC2CC2)c1)c1cc(Br)ccc1F
ring_counting
### Instruction: Count the six-membered rings in the following molecule. COCCCC(=O)N[C@@H](C)c1sc(-c2ccccc2F)nc1C ### Response: 1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. COC(=O)c1ccc([C@@H]2Nc3ccc([N+](=O)[O-])cc3[C@@H]3C=CC[C@H]32)cc1 ### Response: 3
functional_group
### Instruction: Does the molecule contain a ketone group? CCN(C(=O)[C@H]1C=C2C(=O)[NH+]=c3ccc(C)cc3=C2S1)c1cccc(C)c1 ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. c1c(C)c(-n2nnnc2SCC(=O)N2c3c(cccc3)OC[C@H]2c2ccccc2)ccc1 ### Response: Cc1ccccc1-n1nnnc1SCC(=O)N1c2ccccc2OC[C@H]1c1ccccc1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [7*]C1S/C(=N/c2ccc(OC)cc2)NC1=O Fragment 2: [7*]Cc1cc([16*])c(O)c([N+](=O)[O-])c1 ### Response: CCOc1cc(/C=C2\S/C(=N/c3ccc(OC)cc3)NC2=O)cc([N+](=O)[O-])c1O
functional_group
### Instruction: Does the molecule contain a sulfonyl group? CC(=O)Nc1ccc(NC(=O)c2ccc(C)c(-n3cccc3)c2)cc1 ### Response: No
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]CC[C@H]([8*])C Fragment 2: [16*]c1ccc(OC)cc1 ### Response: CCn1ccnc(NCC[C@@H](C)c2ccc(OC)cc2)c1=O
canonicalization
### Instruction: Canonicalize the following SMILES string. c1ccccc1-n1c(C)ncc1C[NH2+][C@@H]1CCC[C@@H](C1)S(=O)(C)=O ### Response: Cc1ncc(C[NH2+][C@@H]2CCC[C@H](S(C)(=O)=O)C2)n1-c1ccccc1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1cc(C(=O)NCCc2nc3ccc(F)cc3[nH]2)ccc1F ### Response: 2
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? c1ccc(CN2CCCC3(C[NH2+]C3)C2)cc1 ### Response: Yes
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CCN(Cc1ccccc1)C(=O)[C@H](C)Sc1nnc2c(Cl)cc(C(F)(F)F)cn12 ### Response: 1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. COC[C@H](NC(=O)Cc1coc(-c2ccc(Cl)cc2)n1)C(N)=O ### Response: 1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Cn1c(=O)oc2cc([N-]S(=O)(=O)c3ccc(Br)s3)ccc21 ### Response: 2
ring_counting
### Instruction: Count the five-membered rings in the following molecule. C[C@H]1CCCN(C(=O)CSc2nnc(-c3ccc([N+](=O)[O-])cc3)o2)C1 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=c1oc2ccccc2cc1C1=NN[C@@H](c2ccccc2Cl)C1 ### Response: 0
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]C[C@H]1CCC[NH2+]1 Fragment 2: [5*]Nc1nc2c(C)cccn2n1 ### Response: Cc1cccn2nc(NC[C@H]3CCC[NH2+]3)nc12
functional_group
### Instruction: Does the molecule contain a amide group? Cc1cnc(C(C)(C)NC(=O)N[C@H]2C[C@H]2C2CCCCC2)s1 ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1cc(-c2nnc(CN3CC[NH+](CC4CCCCC4)CC3)o2)c(C)o1 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [8*]CCc1c[nH]c2ccc(F)cc12 Fragment 2: [5*]Nc1cc(C)cc(C)c1 ### Response: Cc1cc(C)cc(NC(=O)[C@H]2CC(=O)N(CCc3c[nH]c4ccc(F)cc34)C2)c1