task
stringclasses
5 values
input
stringlengths
89
339
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC[C@@H]1CC[C@@](C[NH3+])([C@H](O)c2ccccc2)C1 ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. c1([C@H]([NH2+]CCc2[nH+]c3n(c2)cccc3)C)cnn(c1C)-c1ncccc1 ### Response: Cc1c([C@@H](C)[NH2+]CCc2cn3ccccc3[nH+]2)cnn1-c1ccccn1
functional_group
### Instruction: Does the molecule contain a nitro group? O=C(NC[C@@H](c1cccnc1)N1CCc2ccccc2C1)C(=O)Nc1cccc([N+](=O)[O-])c1 ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. C(N[C@H]1CCC[NH+](C)C1)(N(C)[C@H](C)CSC)=O ### Response: CSC[C@@H](C)N(C)C(=O)N[C@H]1CCC[NH+](C)C1
functional_group
### Instruction: Does the molecule contain a thiol group? CCC(CC)([C@H](Cc1nc(C)cs1)NC)[NH+]1CCCC1 ### Response: No
functional_group
### Instruction: Does the molecule contain a nitro group? CC[C@@H](C)NC(=O)c1ccnc(OC(C)(C)C)c1 ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. c1c(cnc(c1)[C@@H](N[C@@H](c1n(C)cc[nH+]1)c1cc(OC)cc(c1)OC)C)F ### Response: COc1cc(OC)cc([C@@H](N[C@@H](C)c2ccc(F)cn2)c2[nH+]ccn2C)c1
canonicalization
### Instruction: Canonicalize the following SMILES string. n1cc(ccc1)NC([C@@H]1OCCC1)=O ### Response: O=C(Nc1cccnc1)[C@H]1CCCO1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COC(=O)[C@H]1[NH+]=c2ccc(Br)cc2=C1NC(=O)CN1C[C@@H](C)O[C@H](C)C1 ### Response: 2
functional_group
### Instruction: Does the molecule contain a halide group? CCC(=O)N1CCC([NH+]2CCN(c3ncc(Cl)cc3Cl)CC2)CC1 ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. O1CCC[C@]1(c1noc(n1)[C@H]1CCCCC1=O)C ### Response: C[C@@]1(c2noc([C@H]3CCCCC3=O)n2)CCCO1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1ccccc1OCCC(=O)N[C@@H](c1nc(C)cs1)C ### Response: Cc1csc([C@@H](C)NC(=O)CCOc2ccccc2)n1
functional_group
### Instruction: Does the molecule contain a thiol group? CCOC(=O)CN(CC1CC1)C(=O)[C@@H]1SCCc2sccc21 ### Response: No
functional_group
### Instruction: Does the molecule contain a ketone group? C[NH2+][C@H](c1ccc2c(c1)OC[C@H](C)CO2)[C@@H]1CCO[C@@H]1C ### Response: No
functional_group
### Instruction: Does the molecule contain a amine group? Cc1cccc(-c2ccnc(N)n2)c1C ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CN(C(=O)NCc1ccc(N2CCCCCC2)[nH+]c1)C1CCCCC1 ### Response: 1
functional_group
### Instruction: Does the molecule contain a sulfonyl group? Cc1ccccc1OCc1nc2c3cnn(-c4c(F)c(F)cc(F)c4F)c3ncn2n1 ### Response: No
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Cc1nn(CCNS(=O)(=O)NCc2ccccc2)c(C)c1Cl ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1cc(cc(c1C)S(=O)(C)=O)NC(=O)N[C@H]1[C@@H](C1)c1ccccc1 ### Response: Cc1ccc(NC(=O)N[C@@H]2C[C@H]2c2ccccc2)cc1S(C)(=O)=O
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? O=c1c2c3c(sc2n2c([S-])nnc2n1-c1ccccc1)CCCC3 ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C(CSc1nccn1C1CC1)N1CCN(c2cccc(C(F)(F)F)c2)CC1 ### Response: 2
functional_group
### Instruction: Does the molecule contain a amide group? Cc1noc(C)c1CN(C)C(=O)NC[C@H]1CN2CCC[C@@H]2CO1 ### Response: Yes
functional_group
### Instruction: Does the molecule contain a nitrile group? CC(C)CC(=O)N1CCN(C(=O)c2cnc3c(c2)NC(=O)CO3)CC1 ### Response: No
ring_counting
### Instruction: Count the six-membered rings in the following molecule. COc1ccc2c(c1)[C@H](O)[C@H](C)[C@@H]2C ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [10*]N1CCN([10*])C1=O Fragment 2: [1*]C(C)=O ### Response: CC(=O)N1CCN(C(=O)CN2CCN(c3ccc(C(C)C)cc3)C2=O)CC1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1ncsc1C(=O)N[C@H](Cc1cc(=O)[nH]c(-c2ccccn2)n1)c1ccc(F)cc1 ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@@H]1C[C@H](NC(=O)[C@@H](C)[NH+]2CCCCCC2)CC[NH+]1Cc1ccccc1 ### Response: 3
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CCOCCN(C)C(=O)c1ncccc1OC(C)C ### Response: 1
functional_group
### Instruction: Does the molecule contain a hydroxyl group? CCN(C(=O)[C@H](C)c1ccsc1)c1ccc(Br)cn1 ### Response: No
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1nn(C)c2c1[nH]c(=S)n2-c1cc(Cl)c(Cl)cc1Cl ### Response: 1
functional_group
### Instruction: Does the molecule contain a ketone group? CSc1ccc(C(=O)/C=C/c2ccsc2)cc1 ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]NCc1nnsc1Cl Fragment 2: [4*][C@H]([8*])c1ccccc1 ### Response: Fc1cccc([C@@H](NCc2nnsc2Cl)c2ccccc2)c1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. O=C(Nc1ccccc1NCC(F)(F)F)c1[nH]nc(C2CC2)c1Cl ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. C1[C@H](OCC(C)C)C[C@@](NC)(C(OCC)=O)C1 ### Response: CCOC(=O)[C@@]1(NC)CC[C@H](OCC(C)C)C1
canonicalization
### Instruction: Canonicalize the following SMILES string. C1CN(Cc2cscc2)[C@@H]([C@H](C)O1)C ### Response: C[C@@H]1OCCN(Cc2ccsc2)[C@@H]1C
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COC(=O)c1ccc2c(=O)n(CCCN3CCCC3=O)c([S-])nc2c1 ### Response: 3
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CN1C(=O)Cc2cc(S(=O)(=O)Nc3ccc(Br)cc3Cl)ccc21 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. C(C)(CNC(c1cc(S(N2CCOCC2)(=O)=O)c(C)cc1)=O)(C)C ### Response: Cc1ccc(C(=O)NCC(C)(C)C)cc1S(=O)(=O)N1CCOCC1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. O=C(N/N=C\c1ccc(F)cc1)C1=CC=CC2=CC=N[C@H]21 ### Response: 1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. [NH3+][C@@H](CC[C@@H]1CCCO1)c1ccc(Cl)c2ccccc12 ### Response: 1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Cc1ccc2[nH]c([C@H]3CCCN(C(=O)c4ccnn4C(C)C)C3)c(-c3ccncc3)c2c1 ### Response: 3
canonicalization
### Instruction: Canonicalize the following SMILES string. [C@H]1(CCCCC[C@@H]1CO)[NH2+][C@@H](C)c1ccc(cc1OC)OC ### Response: COc1ccc([C@H](C)[NH2+][C@@H]2CCCCC[C@@H]2CO)c(OC)c1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC(C)(C)C1=NN(CCOc2ccc(F)cc2)C(=O)C1 ### Response: 3
canonicalization
### Instruction: Canonicalize the following SMILES string. c1c(NC(C2C(=NC3=C(C(=O)C[C@H](C)C3)[C@@H]2c2ccc(Cl)cc2)C)=O)ncc(c1)C ### Response: CC1=NC2=C(C(=O)C[C@H](C)C2)[C@H](c2ccc(Cl)cc2)C1C(=O)Nc1ccc(C)cn1
functional_group
### Instruction: Does the molecule contain a thiol group? C/C(Cl)=C/Cn1c(SCc2ccc(C)cc2)nc2c1c(=O)[nH]c(=O)n2C ### Response: No
functional_group
### Instruction: Does the molecule contain a ether group? COC(=O)C1=C(CN2CCC(Cc3ccccc3)CC2)NC(=O)N[C@H]1c1cccs1 ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]CCC Fragment 2: [1*]C(=O)c1cn2cc([14*])n(C)c(=O)c2n1 ### Response: CCCN(C(=O)c1cn2cc(-c3ccc(OC)cc3)n(C)c(=O)c2n1)C1CC1
canonicalization
### Instruction: Canonicalize the following SMILES string. C1N(C(=O)CCC2CCCC2)CCC(C1)COc1ccccc1C(N1CCCC1)=O ### Response: O=C(CCC1CCCC1)N1CCC(COc2ccccc2C(=O)N2CCCC2)CC1
canonicalization
### Instruction: Canonicalize the following SMILES string. [C@H]1(NC(=O)c2cc(c(cc2)OC)OC)CCCC[C@H]1C(C)(C)C ### Response: COc1ccc(C(=O)N[C@H]2CCCC[C@H]2C(C)(C)C)cc1OC
functional_group
### Instruction: Does the molecule contain a amide group? CCCC[C@H]1CCC[C@H]1NC(=O)Nc1ccc(C(=O)NC)c(Cl)c1 ### Response: Yes
functional_group
### Instruction: Does the molecule contain a ester group? CCOC(=O)[C@]1(N)CC[C@H]([NH+](C)[C@@H](C)C(C)C)C1 ### Response: Yes
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? CC[C@](C)(NC(=O)Nc1ccc(Cl)cc1)C(=O)[O-] ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCOc1ncccc1C(=O)N1CCC[C@](CC)(C(=O)[O-])C1 ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCOC(=O)C1CCN(C(=O)[C@H]2CCCN(c3cc(-n4nc(C)cc4C)ncn3)C2)CC1 ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)C[4*] Fragment 2: [4*]Cc1cccc([N+](=O)[O-])c1 ### Response: CC[NH+](CC(=O)Nc1ccc2c(c1)OCCO2)Cc1cccc([N+](=O)[O-])c1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C(Nc1cnn(-c2ncccn2)c1)c1cccc(OCC(F)F)n1 ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [8*]CCC(C)C Fragment 2: [15*][C@]1(C[NH3+])CCC(C)(C)[C@H]1O ### Response: CC(C)CC[C@]1(C[NH3+])CCC(C)(C)[C@H]1O
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [15*]C1CC1 Fragment 2: [1*]C(C)=O ### Response: CC(=O)NCc1ccc(-c2csc(C3CC3)n2)s1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]Cc1ccccc1 Fragment 2: [3*]Oc1ccc(/C=N/n2c(C)nnc2C)cc1 ### Response: Cc1nnc(C)n1/N=C/c1ccc(OCc2ccccc2)cc1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1noc(C)c1CCC(=O)Nc1ccnn1C1CCCCC1 ### Response: 3
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [16*]c1cc(C#N)ccc1F Fragment 2: [8*]CS([12*])(=O)=O ### Response: Cn1cc(C(=O)C[C@H]2CCCN2S(=O)(=O)Cc2cc(C#N)ccc2F)cn1
canonicalization
### Instruction: Canonicalize the following SMILES string. C(NC(=O)c1cccc(OC)n1)C[S@@](=O)C(C)(C)C ### Response: COc1cccc(C(=O)NCC[S@@](=O)C(C)(C)C)n1
functional_group
### Instruction: Does the molecule contain a amide group? CC(C)N1C[C@@H](C(=O)N2C[C@@H](O)[C@@H](O)C2)CC1=O ### Response: Yes
functional_group
### Instruction: Does the molecule contain a nitrile group? COc1ccc(C(=O)Nc2ccc(OC(F)F)cc2)cc1F ### Response: No
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Cc1ccc2c(c1)N(C)C(=O)[C@](C)(C(=O)N1CCC(C)CC1)O2 ### Response: 0
ring_counting
### Instruction: Count the five-membered rings in the following molecule. COc1ccc(O)c([C@H](C)NC(=O)Nc2cccc(C)c2Cl)c1 ### Response: 0
ring_counting
### Instruction: Count the six-membered rings in the following molecule. COc1ccccc1N1CCN(C(=O)Cc2c(C)nc(S[C@@H](C)c3ccccc3)[nH]c2=O)CC1 ### Response: 4
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [16*]c1cc(C)c(C)cc1C Fragment 2: [16*]c1ccc(OC)cc1 ### Response: COc1ccc(-n2nnnc2S[C@@H](C)C(=O)c2cc(C)c(C)cc2C)cc1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1ccccc1CN1CCN(c2cc(ncn2)NC(c2c3c(cccc3)ccc2)=O)CC1 ### Response: O=C(Nc1cc(N2CCN(Cc3ccccc3)CC2)ncn1)c1cccc2ccccc12
canonicalization
### Instruction: Canonicalize the following SMILES string. C([NH3+])[C@@H](c1cc(OC)ccc1)N1C[C@H]2CNC(=O)N2CC1 ### Response: COc1cccc([C@H](C[NH3+])N2CCN3C(=O)NC[C@@H]3C2)c1
canonicalization
### Instruction: Canonicalize the following SMILES string. C1CS(=O)(CCC1N(C)C(=O)[C@H](C)OCCCC)=O ### Response: CCCCO[C@@H](C)C(=O)N(C)C1CCS(=O)(=O)CC1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]Cc1cnn(C)c1C Fragment 2: [5*][NH+]1CCc2nc([14*])[nH]c(=O)c2C1 ### Response: Cc1c(C[NH+]2CCc3nc(-c4ccccn4)[nH]c(=O)c3C2)cnn1C
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CCO[C@@H]1C[C@@H]([O-])C12CCN(C(=O)c1cn(C)nc1-c1ccccc1)CC2 ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C(Cc1ccc2c(c1)OCO2)Nc1nc(-c2ccc(Br)s2)cs1 ### Response: 2
functional_group
### Instruction: Does the molecule contain a nitro group? Cc1cccc(COc2cccc(N)c2C)n1 ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. [NH+](CC)(CC)[C@@H](CNC(N1CCCN(CC1)C(=O)c1ccccc1F)=O)C ### Response: CC[NH+](CC)[C@H](C)CNC(=O)N1CCCN(C(=O)c2ccccc2F)CC1
functional_group
### Instruction: Does the molecule contain a amide group? Cc1ccc([C@@H]2CCCN2C(=O)CC[C@H]2NC(=O)N(C3CCCCC3)C2=O)cc1C ### Response: Yes
ring_counting
### Instruction: Count the six-membered rings in the following molecule. O=C(Cn1nc2c(cc1=O)CCCC2)N1CC[C@]2(O)CCCC[C@@H]2C1 ### Response: 4
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=c1c2cn[nH]c2nc(SCc2cn3ccccc3n2)n1-c1ccccc1 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [14*]c1cccs1 Fragment 2: [5*]Nc1ccc2c(c1)OCO2 ### Response: O=C(CSc1nnc(-c2cccs2)n1Cc1ccccc1)Nc1ccc2c(c1)OCO2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]Cc1ccc([N+](=O)[O-])cc1 Fragment 2: [3*]OCc1ccc([N+](=O)[O-])cc1 ### Response: CCN1C(=O)S/C(=C\c2ccc(OCc3ccc([N+](=O)[O-])cc3)c(Cl)c2)C1=O
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C=CCn1cccc(C(=O)N(C)[C@@H](C)C2CC2)c1=O ### Response: 3
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*][NH+]([5*])Cc1ccccc1 Fragment 2: [5*]Nc1nn(C)cc1C#N ### Response: Cn1cc(C#N)c(NC(=O)C[NH+](Cc2ccccc2)Cc2ccccc2)n1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1cc(-c2nnc3ccncn23)ccc1N ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1cccc2c1c(C)c(c(o2)=O)C(=O)Nc1ncc(cc1)Br ### Response: Cc1c(C(=O)Nc2ccc(Br)cn2)c(=O)oc2ccccc12
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)c1cnn([9*])c1C Fragment 2: [8*]C(C)C ### Response: Cc1c(C(=O)OCc2nc3ccccc3o2)cnn1C(C)C
canonicalization
### Instruction: Canonicalize the following SMILES string. C(c1ccc(o1)C[NH+]1[C@@H](CCC1)CC1CCCCC1)O ### Response: OCc1ccc(C[NH+]2CCC[C@H]2CC2CCCCC2)o1
functional_group
### Instruction: Does the molecule contain a sulfonyl group? Cc1cccc(N2CCN(S(=O)(=O)CCCNC(=O)c3cc4ccccc4o3)CC2)c1 ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CNS(=O)(=O)CCCSc1nc2cc(C)ccc2o1 ### Response: 3
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COc1ccnc2c(NC(=O)CNC(=O)c3cccc(C)c3)cccc12 ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N1CCC(CC)(CO)CC1 Fragment 2: [8*]COC ### Response: CCC1(CO)CCN(C(=O)Nc2cc(COC)ncn2)CC1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1cc(ccc1N(C)C)NC(c1csc(n1)Nc1nc(cc(n1)C)C)=O ### Response: Cc1cc(C)nc(Nc2nc(C(=O)Nc3ccc(N(C)C)cc3)cs2)n1
functional_group
### Instruction: Does the molecule contain a ether group? CCOC(=O)C1=C(CN2CCN(c3cccc(C)c3C)CC2)NC(=O)N[C@H]1c1cccs1 ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. c1c2c(-c3ccccc3C2COC(NC2(CCC(CC2)c2ccccc2)C([O-])=O)=O)ccc1 ### Response: O=C(NC1(C(=O)[O-])CCC(c2ccccc2)CC1)OCC1c2ccccc2-c2ccccc21
functional_group
### Instruction: Does the molecule contain a halide group? CC(C)C[NH2+]CCn1ccc2c(Cl)cccc21 ### Response: Yes
functional_group
### Instruction: Does the molecule contain a carboxyl group? O=C(NN1C(=O)[C@H]2C3c4ccccc4C(c4ccccc43)[C@@H]2C1=O)c1cccc([N+](=O)[O-])c1 ### Response: No
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]C[C@H]1CCC[NH+]1[5*] Fragment 2: [4*]Cc1ccccc1 ### Response: C[C@H](NC[C@H]1CCC[NH+]1Cc1ccccc1)c1nccs1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? N#Cc1c(-c2ccco2)nn(-c2ccccc2Br)c1N ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1c(c(cc(c1)C#N)CNC(C(Nc1c(C)c(ccc1)F)=O)=O)F ### Response: Cc1c(F)cccc1NC(=O)C(=O)NCc1cc(C#N)ccc1F
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [16*]c1cc[nH+]cc1 Fragment 2: [5*]N1CCN([5*])CC1 ### Response: C[C@H](NC(=O)C(C)(C)C)C(=O)N1CCN(c2cc[nH+]cc2)CC1