task
stringclasses
5 values
input
stringlengths
89
339
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? N#Cc1ccc(C(=O)N[C@@H]2C=C[C@@H](C(=O)[O-])C2)cc1 ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [16*]c1ccccc1 Fragment 2: [1*]C(=O)c1ccc([16*])cc1 ### Response: COC(=O)[C@H]1[C@@H](c2ccccc2)N1C(=O)c1ccc(-c2ccccc2)cc1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. O=C([O-])C1(Cc2cc(F)cc(Br)c2)CCCCCC1 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COc1ccc(-c2nn3c(C(F)(F)F)nnc3s2)cc1N ### Response: 1
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? CCn1c(Cc2ccccc2)nnc1SCC(=O)N1CCC[C@@H](C)C1 ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]C[C@@H](C)N[5*] Fragment 2: [5*]Nc1cc([N+](=O)[O-])ccc1C ### Response: Cc1ccc([N+](=O)[O-])cc1NC(=O)C(=O)N[C@H](C)C[NH+]1C[C@H](C)C[C@H](C)C1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]Cc1cccc(C)n1 Fragment 2: [5*]N([5*])CC ### Response: CCN(Cc1cccc(C)n1)[C@@H](C[NH3+])C(C)C
canonicalization
### Instruction: Canonicalize the following SMILES string. C1[C@@H](OCC1)c1sc(C(N[C@H](Cc2cccc(c2)F)C)=O)cn1 ### Response: C[C@@H](Cc1cccc(F)c1)NC(=O)c1cnc([C@H]2CCCO2)s1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1noc(C)c1CC(=O)NCc1nnc2n1CCCC2 ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(scc(n1)COC(=O)c1[nH]nc(-c2ccc(cc2)Br)c1)CC ### Response: CCc1nc(COC(=O)c2cc(-c3ccc(Br)cc3)n[nH]2)cs1
functional_group
### Instruction: Does the molecule contain a amide group? C[C@@H]1C[NH2+]CC[C@@H]1NC(=O)Nc1ccccc1F ### Response: Yes
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CCc1nn(C)cc1CNC(=O)N1CC[C@H](C)C[C@H](C)C1 ### Response: 1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. C[C@H](NC(=O)C[C@H](O)c1ccccc1)C(=O)N1CCCC[C@@H]1C ### Response: 0
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Cc1ccc2c(NNC(=O)c3c(O)cccc3O)ccnc2c1 ### Response: 3
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCc1c(C(=O)/C=C/c2ccc(NC(C)=O)cc2)oc2ccccc12 ### Response: 3
canonicalization
### Instruction: Canonicalize the following SMILES string. O=c1sc([nH+]c2c1cccc2)Nc1ccc(cc1)C ### Response: Cc1ccc(Nc2[nH+]c3ccccc3c(=O)s2)cc1
canonicalization
### Instruction: Canonicalize the following SMILES string. c12S[C@@H](C(=O)N3CCOCC3)[C@@H](c3ccc(cc3)OCC)Nn2c(nn1)-c1ccccc1 ### Response: CCOc1ccc([C@H]2Nn3c(nnc3-c3ccccc3)S[C@H]2C(=O)N2CCOCC2)cc1
functional_group
### Instruction: Does the molecule contain a nitrile group? Cc1ccc2cc(C#N)c(SCC(=O)Nc3c(C)cccc3C)nc2c1 ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C=CCOC(=O)Oc1ccc2c(=O)c(-c3ccccc3OC)coc2c1 ### Response: 3
ring_counting
### Instruction: Count the five-membered rings in the following molecule. C[C@@H](C(=O)Nc1ccccc1Cl)n1cc(Br)cn1 ### Response: 1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. COc1cc(C)c(S(=O)(=O)N[C@@H](C#N)c2ccccc2F)cc1OC ### Response: 0
functional_group
### Instruction: Does the molecule contain a nitro group? CC(=O)Nc1ccc(C(=O)/C=C2\NCCc3cc4c(cc32)OCO4)cc1 ### Response: No
ring_counting
### Instruction: Count the five-membered rings in the following molecule. N#C/C(=C\c1ccccc1OCc1cccnc1)C(=O)NCc1ccccc1 ### Response: 0
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [13*][C@H]1Cc2c([nH]c3ccccc23)[C@H](C)N1 Fragment 2: [6*]C(=O)OC ### Response: COC(=O)[C@H]1Cc2c([nH]c3ccccc23)[C@H](C)N1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N1CCOCC1 Fragment 2: [1*]C(=O)[C@@H]1COc2ccc(F)cc2C1 ### Response: O=C(Nc1cccc(N2CCOCC2)c1)[C@@H]1COc2ccc(F)cc2C1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Cc1cccc(S(=O)(=O)N[C@@H]2CC[NH2+]C[C@@H]2C)c1 ### Response: 0
functional_group
### Instruction: Does the molecule contain a halide group? COc1ccc([C@@H]2CCC[NH+]2Cc2ccc([N+](=O)[O-])cc2)c(OC)c1 ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. s1c(ccc1)C[C@@H](C)N(C(Nc1c(cccc1)N(C)C)=O)C ### Response: C[C@H](Cc1cccs1)N(C)C(=O)Nc1ccccc1N(C)C
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N1CC[NH+](CC)CC1 Fragment 2: [15*]C1CCCC1 ### Response: CCCC[C@@H](c1nnnn1C1CCCC1)N1CC[NH+](CC)CC1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [14*]c1[nH]c2ccccc2c1[16*] Fragment 2: [16*]c1ccc(F)cc1 ### Response: CC[C@@H](C)NC(=O)Nc1c(-c2ccc(F)cc2)[nH]c2ccccc12
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CC(C)Cc1cc(C(=O)N2CCC[C@H]2c2nc3ccccc3s2)n(C)n1 ### Response: 3
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N1CC[NH+](C)C(C)(C)C1 Fragment 2: [4*]Cc1cc(NC)cc[nH+]1 ### Response: CNc1cc[nH+]c(CN2CC[NH+](C)C(C)(C)C2)c1
functional_group
### Instruction: Does the molecule contain a ketone group? COc1c([C@H](O)Cc2nc3ccccc3s2)c(C)nn1C ### Response: No
functional_group
### Instruction: Does the molecule contain a amide group? CCOc1ccc([C@@H]2c3c(oc4ccc(C)cc4c3=O)C(=O)N2c2cccc(C)n2)cc1OC ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. C(CC1CCOCC=1)N[C@@H]1C[NH+](CC1)C1CC1 ### Response: C1=C(CCN[C@H]2CC[NH+](C3CC3)C2)CCOC1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]Nc1ccc([N+](=O)[O-])cc1 Fragment 2: [5*][NH+]1CCC[C@H]([15*])C1 ### Response: NC(=O)[C@H]1CCC[NH+](CCCNc2ccc([N+](=O)[O-])cc2)C1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@H](CCc1ccc2c(c1)OCO2)[NH2+][C@@H](CO)c1ccccc1F ### Response: 4
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [14*]c1n[nH]c([14*])n1 Fragment 2: [8*]Cc1nc([14*])n[nH]1 ### Response: [NH3+]CCc1n[nH]c(Cc2ccc([N+](=O)[O-])cc2)n1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=c1[nH]nc(CN2CCN(c3cc(F)ccc3F)CC2)[nH]1 ### Response: 1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. C[NH2+][C@@H](c1cccc(OC)c1)C(OC)OC ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. c12[C@@H](NC(Nc3cc(c([S@](=O)C)cc3)F)=O)CCc2cccc1 ### Response: C[S@@](=O)c1ccc(NC(=O)N[C@H]2CCc3ccccc32)cc1F
canonicalization
### Instruction: Canonicalize the following SMILES string. c1c(c(ccc1NC(=O)Cn1c2c(cccc2c(C)cc1=O)C)OC)Cl ### Response: COc1ccc(NC(=O)Cn2c(=O)cc(C)c3cccc(C)c32)cc1Cl
canonicalization
### Instruction: Canonicalize the following SMILES string. c1([N+]([O-])=O)ccc(cc1)-n1nc(c(/C=[NH+]\CCN2CC[NH2+]CC2)c1O)-c1ccccc1 ### Response: O=[N+]([O-])c1ccc(-n2nc(-c3ccccc3)c(/C=[NH+]\CCN3CC[NH2+]CC3)c2O)cc1
canonicalization
### Instruction: Canonicalize the following SMILES string. CCSc1c(C(=O)Nc2cc(ccc2C)C(N)=O)cc(cc1)Cl ### Response: CCSc1ccc(Cl)cc1C(=O)Nc1cc(C(N)=O)ccc1C
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCNC(=O)[C@@H](NC(=O)OC(C)(C)C)[C@H](C)CC ### Response: 5
functional_group
### Instruction: Does the molecule contain a ether group? C=CCOCCCC(=O)N1CCO[C@H](c2ccccc2F)C1 ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [6*]C(=O)N=[N+]=[N-] Fragment 2: [16*]c1ccc2sccc2c1 ### Response: [N-]=[N+]=NC(=O)c1ccc2sccc2c1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CC(C)(C)OC(=O)N1CCOC2(C[NH2+]C2)C1 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [14*]c1n[nH]c(C)n1 Fragment 2: [4*][C@H](C)C(=O)OC ### Response: COC(=O)[C@@H](C)Oc1ccc(C[NH+]2CCC(c3n[nH]c(C)n3)CC2)cc1
functional_group
### Instruction: Does the molecule contain a hydroxyl group? CS(=O)(=O)/N=C(\[O-])[C@H]1CCCN1C(=O)c1ccc2c(c1)OCO2 ### Response: No
functional_group
### Instruction: Does the molecule contain a hydroxyl group? Cc1ccc(-c2ccc([C@@H]3C(C#N)=C(N)Oc4[nH]c(=S)[nH]c(=O)c43)o2)cc1 ### Response: No
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C(c1ccc[n+]([O-])c1)N1CC[C@H](Nc2ccccc2)C1 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1cc(C)n(CC(=O)N(CC2CC[NH+](C3CCCC3)CC2)C[C@H]2CCCO2)n1 ### Response: 2
ring_counting
### Instruction: Count the six-membered rings in the following molecule. O=C(Cn1cc(C2CC2)nn1)NC1c2ccccc2Oc2ccccc21 ### Response: 3
functional_group
### Instruction: Does the molecule contain a sulfonyl group? CC1(C)[C@H](NC(=O)CCNC(=O)C23CC4CC(CC(C4)C2)C3)[C@H]2CCO[C@@H]21 ### Response: No
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C(NCC[C@@H](O)C1CC1)c1cc(=O)c2ccccc2o1 ### Response: 3
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COc1ccc(CN2CCOC[C@H]2C(N)=O)cc1[N+](=O)[O-] ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C(CCn1cncn1)Nc1ccnn1Cc1ccccc1 ### Response: 3
functional_group
### Instruction: Does the molecule contain a sulfonyl group? CC(C)(C)Cc1nnc(NC(=O)CS(=O)(=O)c2ccccc2)s1 ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCc1ccc([C@@H]2COCCN2Cc2nc(CCC(C)C)no2)o1 ### Response: 4
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)c1ccc([O-])nn1 Fragment 2: [14*]c1cccs1 ### Response: O=C(Nc1ccc(Sc2cccs2)cn1)c1ccc([O-])nn1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1c(c(cnc1)C#CC[NH3+])C(N[C@@H](C)CCC(C)C)=O ### Response: CC(C)CC[C@H](C)NC(=O)c1ccncc1C#CC[NH3+]
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]NCc1ncc(C)s1 Fragment 2: [4*]Cc1ncc(C)s1 ### Response: Cc1cnc(CNC(=O)N2CCC(CN3CCOCC3)CC2)s1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COC(=O)c1cc(NC(=O)c2cn(C)nc2C(C)(C)C)c(F)cc1F ### Response: 3
canonicalization
### Instruction: Canonicalize the following SMILES string. C(NCCC)([C@H]1CCCN(C(=O)N[C@H]2C[C@@](C2(C)C)(C)OC)C1)=O ### Response: CCCNC(=O)[C@H]1CCCN(C(=O)N[C@H]2C[C@@](C)(OC)C2(C)C)C1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [14*]c1[nH]ncc1CC Fragment 2: [4*]Cc1cccn1[9*] ### Response: CCc1cn[nH]c1[C@@H]1CCCN(Cc2cccn2-c2nccs2)C1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[NH2+]Cc1cc(Cl)ccc1O[C@@H](C)C(=O)NC(C)(C)C ### Response: 3
canonicalization
### Instruction: Canonicalize the following SMILES string. C(Cc1ccc(cc1)OC(C)C)NC(=O)Nc1noc(C)c1 ### Response: Cc1cc(NC(=O)NCCc2ccc(OC(C)C)cc2)no1
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? Cc1c(N2C(=O)/C(=C\c3ccc4c(c3)C[C@@H](C)O4)SC2=S)c(=O)n(-c2ccccc2)n1C ### Response: Yes
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Cc1cc(C(=O)Nc2nc(-c3ccc(OC(F)F)cc3)c(C)s2)no1 ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. [C@@H]1(CCC[NH+]1CCCCS(=O)(=O)C)Cc1cc2ccccc2cc1 ### Response: CS(=O)(=O)CCCC[NH+]1CCC[C@@H]1Cc1ccc2ccccc2c1
canonicalization
### Instruction: Canonicalize the following SMILES string. C1C(C(NCc2ccco2)=O)CCN(c2cnnc(c2Cl)[O-])C1 ### Response: O=C(NCc1ccco1)C1CCN(c2cnnc([O-])c2Cl)CC1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O[C@H](CC1CCCCC1)c1ccc(F)cn1 ### Response: 2
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CC(=O)Nc1cccc(-c2nc(-c3ccc4ncn(C(C)C)c4c3)no2)c1 ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]Nc1ccc(C#N)c(N)c1 Fragment 2: [3*]OCC[4*] ### Response: N#Cc1ccc(NCCOc2ccccc2)cc1N
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@H](Cc1ccsc1)N(C)C(=O)Nc1c(F)cc(F)cc1F ### Response: 3
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CN(C)c1ccc2nc([C@H]([NH3+])CO)[nH]c2n1 ### Response: 2
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CC(C)(C)n1ncc2c1CCC[C@H]2NC(=O)CSc1nc2ccccc2o1 ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)C[4*] Fragment 2: [16*]c1ccc(F)c(C)c1 ### Response: Cc1cc(-n2c(SCC(=O)N3CCCC[C@H]3C)nc3ccsc3c2=O)ccc1F
functional_group
### Instruction: Does the molecule contain a amide group? C[C@H]1CN(CC(=O)N(CCC(N)=O)c2ccc(F)cc2)C(C)(C)CO1 ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]Nc1ncccn1 Fragment 2: [1*]C(=O)c1csc([14*])n1 ### Response: O=C(Nc1ccccc1)c1csc(Nc2ncccn2)n1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [3*]OCC[4*] Fragment 2: [4*]CC[NH+]1CCN([5*])CC1 ### Response: c1ccc(OCC[NH+]2CCN(c3ccccc3)CC2)cc1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CCC[NH2+]C[C@]1(c2ccccc2OC)CC[C@H]1C ### Response: 0
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC[NH2+]C[C@H](Cc1nc(C)cs1)c1ccccc1F ### Response: 3
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C#CCn1/c(=N/S(=O)(=O)c2ccc(C)cc2)sc2cccc(F)c21 ### Response: 3
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [12*]S(C)(=O)=O Fragment 2: [5*]N(C)C ### Response: CCN(c1ccc(C(=O)N(C)C)cc1)S(C)(=O)=O
functional_group
### Instruction: Does the molecule contain a amide group? CN(C)S(=O)(=O)c1ccc(NC(=O)C(C)(C)C)cc1 ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]CCC Fragment 2: [4*][C@@H]([8*])[C@@]1(C)CCCO1 ### Response: CCC[NH2+][C@@H](C1CC1)[C@@]1(C)CCCO1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. C[C@H](C(=O)[O-])N1C(=O)/C(=C/c2ccccc2F)SC1=S ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. N(c1cccc(-c2oc(C)c(n2)C)c1)C(NC[C@@H](C)[NH+]1C[C@@H](C)CCC1)=O ### Response: Cc1nc(-c2cccc(NC(=O)NC[C@@H](C)[NH+]3CCC[C@H](C)C3)c2)oc1C
canonicalization
### Instruction: Canonicalize the following SMILES string. COc1ccc(Cl)cc1N(S(C)(=O)=O)[C@H](C(=O)Nc1c(C)c(ccc1)[N+](=O)[O-])C ### Response: COc1ccc(Cl)cc1N([C@@H](C)C(=O)Nc1cccc([N+](=O)[O-])c1C)S(C)(=O)=O
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Nc1c(NNC(=O)c2ccc(Cl)cc2Cl)ncnc1NC1CCCCC1 ### Response: 3
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1ccc([N+](=O)[O-])cc1NC(=O)N(C)CC[NH+](C)C1CCN(C)CC1 ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COc1ccc2c(C(=O)Nc3cccc(C)c3C)cc(=O)oc2c1 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]NCCC Fragment 2: [4*]CCC ### Response: CCCN[C@H](C#N)CCn1ccnc1C#N
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC[C@H](C)[C@H](NC(=O)N1CCCCC1)C(=O)[O-] ### Response: 5
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC[C@@H](C)NC(=O)c1ccc(NC(=O)c2cnoc2C)cc1O ### Response: 4
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C(N[C@H](C(=O)[O-])C1CC1)c1ccncc1Cl ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(cccc(c1)C(OCC)=O)NC(=O)Cc1c(cccc1)F ### Response: CCOC(=O)c1cccc(NC(=O)Cc2ccccc2F)c1
functional_group
### Instruction: Does the molecule contain a ether group? CC(=O)O[C@@H]1CC[C@@]2(C)[C@@H](CC[C@H]3[C@H]2C[C@H](OC(C)=O)[C@]2(C)[C@@H](C(C)=O)CC[C@H]32)C1 ### Response: Yes