task
stringclasses
5 values
input
stringlengths
89
339
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(NCCNC(=O)C2C[C@@H](C)O[C@H](C2)C)n[nH+]c(C)cc1 ### Response: Cc1ccc(NCCNC(=O)C2C[C@@H](C)O[C@@H](C)C2)n[nH+]1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CCc1c(C)nn(C(=O)COc2cccc(C)c2C)c1C ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [16*]c1ccn(C)c1 Fragment 2: [4*]Cc1cccc([16*])c1 ### Response: Cn1ccc(C[NH+](C)Cc2cccc(OC(F)(F)F)c2)c1
canonicalization
### Instruction: Canonicalize the following SMILES string. C1CC(CCC1C[NH3+])C[NH+]1C[C@@H](C)CCC1 ### Response: C[C@H]1CCC[NH+](CC2CCC(C[NH3+])CC2)C1
canonicalization
### Instruction: Canonicalize the following SMILES string. [O-]C(COc1c(I)cc(cc1OC)C#N)=O ### Response: COc1cc(C#N)cc(I)c1OCC(=O)[O-]
canonicalization
### Instruction: Canonicalize the following SMILES string. Cc1ccc(c(n1CC)=O)-c1nc(on1)CCC(N[C@@H](C)c1ccc(Cl)cc1)=O ### Response: CCn1c(C)ccc(-c2noc(CCC(=O)N[C@@H](C)c3ccc(Cl)cc3)n2)c1=O
canonicalization
### Instruction: Canonicalize the following SMILES string. N(c1c(c(NCCC(C)C)ncn1)N)c1cccc(c1C)C ### Response: Cc1cccc(Nc2ncnc(NCCC(C)C)c2N)c1C
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C(Cn1c(=O)oc2ccccc21)NCc1cn(Cc2ccccc2)nc1-c1ccccc1 ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)c1cc2c([nH]c1=O)CCCC2 Fragment 2: [5*]NCc1ccc2c(c1)OCCCO2 ### Response: O=C(NCc1ccc2c(c1)OCCCO2)c1cc2c([nH]c1=O)CCCC2
canonicalization
### Instruction: Canonicalize the following SMILES string. N(c1ccc(C)c(Br)c1)C(=O)[C@@H]1C[C@H]2CC[C@@H]1O2 ### Response: Cc1ccc(NC(=O)[C@@H]2C[C@H]3CC[C@@H]2O3)cc1Br
canonicalization
### Instruction: Canonicalize the following SMILES string. C1CCCN(C(=O)OC(C)(C)C)[C@@H]1CNC(=O)[C@@H]1COc2c(O1)cccc2 ### Response: CC(C)(C)OC(=O)N1CCCC[C@H]1CNC(=O)[C@@H]1COc2ccccc2O1
canonicalization
### Instruction: Canonicalize the following SMILES string. O1c2cc(Br)c(cc2OC1)[C@H]([NH3+])C([O-])=O ### Response: [NH3+][C@H](C(=O)[O-])c1cc2c(cc1Br)OCO2
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CCOC(=O)[C@]12C(=C(c3ccccc3)O[C@@H]3C=CCC[C@H]31)C(=O)C(=O)N2c1ccccc1 ### Response: 4
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1ccc([C@H](CO)[C@H]2CCS(=O)(=O)C2)cc1 ### Response: 2
functional_group
### Instruction: Does the molecule contain a ester group? Cc1cc2ccccc2c(=O)n1N ### Response: No
functional_group
### Instruction: Does the molecule contain a nitrile group? COc1ccc(C(=O)CNC(=O)c2cc(Cl)ccc2O)cc1 ### Response: No
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [14*]c1cccs1 Fragment 2: [5*]N1CCC([15*])CC1 ### Response: COC(=O)C1=C(CN2CCC(Cc3ccccc3)CC2)NC(=O)N[C@H]1c1cccs1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Cc1ccc(NC(=S)NC(C)C)cc1C ### Response: 0
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)CN[5*] Fragment 2: [1*]C(=O)c1ccc(C)c(C)c1 ### Response: Cc1ccc(C(=O)NCC(=O)NCc2ccccc2F)cc1C
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)c1ccc([16*])cc1 Fragment 2: [1*]C(=O)CC ### Response: CCC(=O)N1CCc2cc(-c3ccc(C(=O)N4CCN(c5cccc(OC)c5)CC4)cc3)ccc21
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Cc1ccc2nc(S[C@H](C)C(=O)NC3CCC(C)CC3)n(C)c(=O)c2c1 ### Response: 0
canonicalization
### Instruction: Canonicalize the following SMILES string. c1cc(ccc1C)C(=O)N1Cc2c(CC1)nc(NC(=O)c1noc(C)c1)s2 ### Response: Cc1ccc(C(=O)N2CCc3nc(NC(=O)c4cc(C)on4)sc3C2)cc1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@H]([NH2+][C@H](C)c1cc(F)cc(F)c1)c1cc(F)ccc1F ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCn1nc(C)c2nc([C@@H](C)Cl)n(-c3ccn(C)n3)c21 ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? NC(=O)c1cccc(CNC(=O)Nc2cccc(-c3nccs3)c2)c1 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [16*]c1c(C)nn(C)c1C Fragment 2: [6*]C(=O)C1=C([O-])C(=O)N(C)[C@@H]1[13*] ### Response: CCOc1cccc([C@@H]2C(C(=O)c3c(C)nn(C)c3C)=C([O-])C(=O)N2C)c1
canonicalization
### Instruction: Canonicalize the following SMILES string. CO[C@@H](c1nc(on1)[C@@H]([NH3+])CCS(=O)(=O)C)C ### Response: CO[C@H](C)c1noc([C@@H]([NH3+])CCS(C)(=O)=O)n1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [3*]Oc1cc(C)ccc1C[4*] Fragment 2: [3*]Oc1cc(C)ccc1CN[5*] ### Response: COCCCOc1cc(C)ccc1CNC(=O)N1CCCC1(C)C
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [3*]Oc1cccc(OC)n1 Fragment 2: [15*][C@@H]1CC[C@H]([NH3+])C1 ### Response: COc1cccc(O[C@@H]2CC[C@H]([NH3+])C2)n1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C1N[C@@]2(CCOc3ccccc32)C(=O)N1Cc1ccc(F)c2cccnc12 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CS(=O)(=O)N1CCN(S(=O)(=O)c2cccc(C(F)(F)F)c2)CC1 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*][NH+]1CCCC[C@H]1CC Fragment 2: [1*]C(=O)NCC[4*] ### Response: CC[C@@H]1CCCC[NH+]1CCNC(=O)N[C@@H]1CCC[C@H]([S@@](=O)CC)C1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [11*]SC[C@@H]1CCCO1 Fragment 2: [4*]C[C@@H]1CCCO1 ### Response: FC(F)(F)c1cccc(-c2noc(CSC[C@@H]3CCCO3)n2)c1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N[C@H]1CCc2ccccc21 Fragment 2: [1*]C(=O)N1CCN([5*])CC1 ### Response: O=C(N[C@H]1CCc2ccccc21)N1CCN(C(=O)c2ccccc2O)CC1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. C[C@H](NC(=O)Cc1ccccc1O)c1cccc(NC(=O)c2ccccc2)c1 ### Response: 3
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CC(C)C(=O)Nc1cccc(OCC(=O)Nc2ccccc2-c2ccccc2)c1 ### Response: 0
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? C[C@@H](NC(=O)CCCN1C(=O)/C(=C/c2c3ccccc3cc3ccccc23)SC1=S)C(=O)[O-] ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C(CC1(O)CCCCC1)NCc1ccc(-c2cccnc2)cc1 ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. c1c(nc(n(c1C)CCC(N1[C@H]2c3cnc4n(nc(c4)C)c3C[C@@H]1CC2)=O)=O)C ### Response: Cc1cc(C)n(CCC(=O)N2[C@H]3CC[C@@H]2c2cnc4cc(C)nn4c2C3)c(=O)n1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [15*]C12CC3CC(CC(C3)C1)C2 Fragment 2: [5*]NCc1cc(C)[nH]n1 ### Response: Cc1cc(CNC(=O)c2cnc(C34CC5CC(CC(C5)C3)C4)[nH]c2=O)n[nH]1
functional_group
### Instruction: Does the molecule contain a ketone group? OC[C@H]1O[C@H](O)[C@@H](F)[C@@H]1O ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. [NH+](C1CC1)(CC(Nc1ccc(F)cc1)=O)[C@H](C1CC1)C ### Response: C[C@@H](C1CC1)[NH+](CC(=O)Nc1ccc(F)cc1)C1CC1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [16*]c1ccc(OC)cc1OC Fragment 2: [6*]C(=O)N=c1[nH]c2ccccc2[nH]1 ### Response: COc1ccc(N2C[C@H](C(=O)N=c3[nH]c4ccccc4[nH]3)CC2=O)c(OC)c1
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? CN(Cc1ccccn1)C(=O)N[C@H]1CCC[C@H]1c1ccc(F)cc1 ### Response: Yes
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Cc1ccc(C(=O)NC2CC[NH+](Cc3nc(-c4ccccc4)cs3)CC2)s1 ### Response: 2
functional_group
### Instruction: Does the molecule contain a hydroxyl group? CCOC(=O)[C@H](NC(C)=O)[C@H](O)c1ccccc1[N+](=O)[O-] ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [15*]C1CC([NH3+])C1 Fragment 2: [16*]c1ccccc1F ### Response: [NH3+]C1CC(c2ccccc2F)C1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cn1cc(N2CCC[C@H](Nc3nccc(OCc4ccccc4)n3)C2)cn1 ### Response: 1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. O=C(CS(=O)(=O)Cc1noc(C2CC2)n1)Nc1ccc(F)c(F)c1 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N[C@@H]1N=NNN1 Fragment 2: [16*]c1ccc(Cl)cc1 ### Response: Clc1ccc(-c2ccc(CN[C@@H]3N=NNN3)o2)cc1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Cc1ccc(CNC(=O)Nc2ccn(C)n2)c(N(C)C)c1 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1cccc(Cl)c1CNC(=O)C1CC[NH+](CC1)Cc1nc(oc1C)-c1ccc(Cl)cc1 ### Response: Cc1oc(-c2ccc(Cl)cc2)nc1C[NH+]1CCC(C(=O)NCc2ccccc2Cl)CC1
canonicalization
### Instruction: Canonicalize the following SMILES string. C([C@H](C(=O)N1C[C@@H](C)C[C@@H](C1)C)NC(=O)c1ccccc1)CSC ### Response: CSCC[C@@H](NC(=O)c1ccccc1)C(=O)N1C[C@@H](C)C[C@H](C)C1
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? CCCc1c(C[NH2+]C)cnn1-c1cccc(Br)c1 ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@@H]1CCC[C@@](C(=O)c2ccc(F)c(F)c2F)([NH+](C)C)C1 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. O=C(COc1c(Br)cc(cc1Cl)Cl)NNC(=O)c1ccc(cc1)[N+](=O)[O-] ### Response: O=C(COc1c(Cl)cc(Cl)cc1Br)NNC(=O)c1ccc([N+](=O)[O-])cc1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Cc1cc(OC(=O)Cn2ncc3ccccc3c2=O)ccc1Cl ### Response: 3
functional_group
### Instruction: Does the molecule contain a ether group? CCC[NH2+][C@@H](CC)c1nnc(-c2sccc2CC)o1 ### Response: No
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCCC(=O)N1CCC([NH+]2CCC[C@@H](C(=O)NCc3cccnc3)C2)CC1 ### Response: 4
ring_counting
### Instruction: Count the five-membered rings in the following molecule. COC[C@H](O)C[NH+]1CCC(NCc2ccc(F)cc2)CC1 ### Response: 0
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CCCc1cc(NC(=O)N[C@H](CC)c2cccc([N+](=O)[O-])c2)n(C)n1 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*][C@H]([8*])c1ccc(Br)c2ccccc12 Fragment 2: [15*][C@H]1CCOC1 ### Response: CC[NH2+][C@@H](c1ccc(Br)c2ccccc12)[C@H]1CCOC1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1c(OC)c(c(-c2nc(N)nc(-c3ccc(cc3)-c3ccccc3)c2)cc1)OC ### Response: COc1cccc(-c2cc(-c3ccc(-c4ccccc4)cc3)nc(N)n2)c1OC
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [16*]c1ccccc1S(N)(=O)=O Fragment 2: [12*]S(=O)(=O)c1ccccc1Br ### Response: NS(=O)(=O)c1ccccc1[N-]S(=O)(=O)c1ccccc1Br
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [9*]n1c[nH+]cc1[14*] Fragment 2: [8*][C@H](O)C[C@H](C)CC ### Response: CC[C@@H](C)C[C@@H](O)c1c[nH+]cn1C(C)C
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC(=O)NCc1ccc(C(=O)N2CCCC[C@H]([NH+]3CCCC3)C2)cc1 ### Response: 2
functional_group
### Instruction: Does the molecule contain a nitrile group? CC(C)(C)c1ccc2oc([C@H]3CCCCC[C@@H]3[NH3+])nc2c1 ### Response: No
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)c1nn([9*])c(=O)n([9*])c1=O Fragment 2: [5*]N(CC)CC ### Response: CCN(CC)C(=O)c1nn(-c2ccc(OC)cc2)c(=O)n(Cc2cccc(F)c2)c1=O
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Fc1ccc(-c2ccc(C[NH2+]CC[C@H]3CCCO3)o2)cc1 ### Response: 2
functional_group
### Instruction: Does the molecule contain a ketone group? C[C@H]1C[NH+]2CCC[C@@H]2CN1c1ccc(F)cc1CCl ### Response: No
functional_group
### Instruction: Does the molecule contain a aldehyde group? C/C=C(/C)C(=O)N1CCN(c2[nH+]ncc3ccccc23)CC1 ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. C1[C@](C)(OCCN1Cc1c(-n2nccc2)cccc1)c1cn(nc1)C ### Response: Cn1cc([C@]2(C)CN(Cc3ccccc3-n3cccn3)CCO2)cn1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CNc1cc([C@H]2CCCN(Cc3cccc(OC)c3OC)C2)nc(-c2ccncc2)n1 ### Response: 4
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CC[C@@H]1CN(C(=O)N[C@@H](C)c2ccc(Cl)s2)C[C@@H](C)O1 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*][C@H](C)c1ccco1 Fragment 2: [14*]c1ccco1 ### Response: COc1cccc(-c2noc([C@@H](C)NC(=O)N(C)[C@H](C)c3ccco3)n2)c1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCCN1CC[NH+]([C@@H]2CCC[C@@](NC)(C(N)=O)C2)CC1 ### Response: 3
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1ccc(C)c(C(=O)CCC(=O)N2CCN(Cc3cccnc3)CC2)c1 ### Response: 4
canonicalization
### Instruction: Canonicalize the following SMILES string. C1[NH+](C(CO)CO)C[C@H](NC(=O)c2cscc2)[C@H]1C1CC1 ### Response: O=C(N[C@H]1C[NH+](C(CO)CO)C[C@@H]1C1CC1)c1ccsc1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@@H]1CN(C[C@@H]2CCCN2S(=O)(=O)c2ccc3c(c2)CCCC3)C[C@H](C)O1 ### Response: 1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CN(C[C@@H]1CCC[NH+]1CC(N)=O)C(=O)OC(C)(C)C ### Response: 1
functional_group
### Instruction: Does the molecule contain a amine group? CC[C@@H](C(=O)N1CCC[C@@H](O)C1)c1ccccc1 ### Response: No
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CN1C(=O)c2ccc(C(=O)OCc3ccccc3)cc2C1=O ### Response: 1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CCC[NH+](C1CCC([NH3+])CC1)[C@H]1CCOC1 ### Response: 1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. COC(=O)N[C@H](C(=O)Nc1ccnc(-c2ccccc2)n1)C(C)C ### Response: 2
functional_group
### Instruction: Does the molecule contain a carboxyl group? CCCNC(=O)[C@H]1CCCN1S(=O)(=O)c1ccc(Cl)cc1 ### Response: No
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]CCC[7*] Fragment 2: [4*]CCC ### Response: CCC[NH2+]CC/C=C(/C)C1CCCCC1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCN(CC)S(=O)(=O)c1cccc(NC(=O)CN2C(=O)N[C@@]3(CCOc4ccccc43)C2=O)c1 ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CN1CC[NH+](C)C[C@H]1c1nc2c(c(=O)[nH]1)CCCN2 ### Response: 1
functional_group
### Instruction: Does the molecule contain a amide group? CC[C@@H]1CN(CC(=O)N(C)Cc2cccs2)CC[NH+]1C[C@@H](C)O ### Response: Yes
functional_group
### Instruction: Does the molecule contain a halide group? Cc1ccoc1C(=O)N[C@@H]1CCS(=O)(=O)C1 ### Response: No
functional_group
### Instruction: Does the molecule contain a thiol group? C[C@H](CNC(=O)NCCc1cnn(C)c1)N1CCOCC1 ### Response: No
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N1/C(=N/C(=O)CCC)S[C@@H]2CS(=O)(=O)C[C@@H]21 Fragment 2: [16*]c1ccc(Cl)cc1 ### Response: CCCC(=O)/N=C1\S[C@@H]2CS(=O)(=O)C[C@@H]2N1c1ccc(Cl)cc1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]C[C@@H]1[C@H](O)C(C)(C)OC1(C)C Fragment 2: [5*][NH+](C)C ### Response: C[NH+](C)C1CCN(C[C@@H]2[C@H](O)C(C)(C)OC2(C)C)CC1
functional_group
### Instruction: Does the molecule contain a ether group? COc1ccc(S(=O)c2ccc(OC)cc2)cc1 ### Response: Yes
functional_group
### Instruction: Does the molecule contain a amide group? Cc1ccc(NC(=O)NCc2ncoc2C)cc1 ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)[C@@H]1CCC[NH2+][C@H]1C Fragment 2: [5*]N1CCOCC1 ### Response: C[C@@H]1[NH2+]CCC[C@H]1C(=O)N[C@@H](C)CN1CCOCC1
functional_group
### Instruction: Does the molecule contain a ether group? c1ccc(N[C@@H]2CCN(Cc3ccn[nH]3)C2)cc1 ### Response: No
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCCCC(=O)OCc1ccco1 ### Response: 5
canonicalization
### Instruction: Canonicalize the following SMILES string. c1nc2c3c(ccc(C)c3)[nH]c2c(=O)n1CCC(=O)Nc1cc(c(OC)cc1)Cl ### Response: COc1ccc(NC(=O)CCn2cnc3c([nH]c4ccc(C)cc43)c2=O)cc1Cl
ring_counting
### Instruction: Count the six-membered rings in the following molecule. C[C@@H](CCCO)NC(=O)N(C)[C@@H]1CCN(c2ccccc2Cl)C1=O ### Response: 1