task
stringclasses
5 values
input
stringlengths
89
339
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]Cc1cc(C)c(F)c(C)c1 Fragment 2: [5*]NCC(=C)Cl ### Response: C=C(Cl)CNCc1cc(C)c(F)c(C)c1
functional_group
### Instruction: Does the molecule contain a carboxyl group? C[C@@H](NC(=O)[C@H](C)c1ccsc1)c1ccc(N2CCOCC2)cc1 ### Response: No
ring_counting
### Instruction: Count the six-membered rings in the following molecule. N/C(=N\[N+](=O)[O-])N/N=C/c1ccc(Cl)cc1Cl ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [7*]Cc1c(OC)cc(OC)cc1OC Fragment 2: [5*][NH2+]C1CC1 ### Response: COc1cc(OC)c(/C=C(/C)C[NH2+]C2CC2)c(OC)c1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1c(ccc(C(=O)N2C[C@@H](O[C@@H](C)C2)C)c1)NCc1nc(no1)-c1cc(ccc1)C ### Response: Cc1cccc(-c2noc(CNc3ccc(C(=O)N4C[C@H](C)O[C@@H](C)C4)cc3)n2)c1
functional_group
### Instruction: Does the molecule contain a aldehyde group? C#CCN1CCN(C(=O)NC2CCN(C(=O)OCC)CC2)CC1 ### Response: No
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [8*][C@H](C)[NH2+]C Fragment 2: [5*]N([5*])CC ### Response: CCN(CC(F)(F)F)c1ccc([C@H](C)[NH2+]C)c(O)c1
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? Cc1cc(NC(=O)/C=C/c2cn(C)c(=O)n(C)c2=O)c2ncccc2c1 ### Response: Yes
functional_group
### Instruction: Does the molecule contain a amide group? CC[NH+](CC)[C@@H]1CCN(C(=O)Nc2cc(-c3ncco3)ccc2C)C1 ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C(CSc1nnc2ccc(-c3ccco3)nn12)c1cccs1 ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. N(c1cc([C@H]2N(CCC2)C(Cc2c(CC)noc2CC)=O)ccc1)(C)C ### Response: CCc1noc(CC)c1CC(=O)N1CCC[C@H]1c1cccc(N(C)C)c1
canonicalization
### Instruction: Canonicalize the following SMILES string. N1[C@@H](C(N/N=C/C=C/c2ccccc2)=O)C=C(C2CC2)N=1 ### Response: O=C(N/N=C/C=C/c1ccccc1)[C@H]1C=C(C2CC2)N=N1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*][NH2+][C@H]1CCC[C@H](C)C1 Fragment 2: [4*]C[C@@H]([8*])O ### Response: C[C@H]1CCC[C@H]([NH2+]C[C@H](O)c2ccccc2Cl)C1
functional_group
### Instruction: Does the molecule contain a carboxyl group? CCc1ncc(CN(C)c2cnccc2C#N)s1 ### Response: No
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Clc1ccc(-c2csc(CN3CCOCC3)n2)c(Cl)c1 ### Response: 1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. O=C(c1ccc[nH]c1=O)N1C[C@H]2CC[C@@H]1C[NH+](CCCc1ccccc1)C2 ### Response: 0
canonicalization
### Instruction: Canonicalize the following SMILES string. C1c2c(C#N)c(N3CCC(Cc4ccccc4)CC3)n3c(nnc3)c2CN(C(C)C)C1 ### Response: CC(C)N1CCc2c(C#N)c(N3CCC(Cc4ccccc4)CC3)n3cnnc3c2C1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1ccc(C(=O)CCC(=O)Nc2ncccc2C)cc1 ### Response: 4
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C(Nc1nc2c(Cl)cccc2s1)c1ccno1 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC(C)CCC(=O)N1C[C@H](C)O[C@@H](C)C1 ### Response: 5
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Cc1nc(CNC(=O)Cn2nc(-c3ccc(F)cc3)oc2=O)cs1 ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC/[NH+]=C(/NCc1ccc(C#N)cc1)N[C@@H]1CCN(c2ccccc2)C1 ### Response: 2
functional_group
### Instruction: Does the molecule contain a nitrile group? CC[C@H](C)NC(=O)c1cc(Br)ccc1OC(C)C ### Response: No
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N1CCCc2ccccc21 Fragment 2: [1*]C(=O)c1cccc(S([12*])(=O)=O)c1 ### Response: C[C@H]1CCCCN1C(=O)c1cccc(S(=O)(=O)N2CCCc3ccccc32)c1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. C[C@H](SCC[NH3+])c1ccc(C(=O)[O-])o1 ### Response: 0
canonicalization
### Instruction: Canonicalize the following SMILES string. C(C(=O)N1C[C@H](n2cc[nH+]c2)CCC1)n1c2ccccc2oc1=O ### Response: O=C(Cn1c(=O)oc2ccccc21)N1CCC[C@@H](n2cc[nH+]c2)C1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1c(cccc1)CCNC(=O)CN1C(CCC1=O)=O ### Response: O=C(CN1C(=O)CCC1=O)NCCc1ccccc1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]Cc1ccsc1 Fragment 2: [5*]NS(=O)(=O)c1ccc(F)c(F)c1F ### Response: O=S(=O)(NCc1ccsc1)c1ccc(F)c(F)c1F
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]Cc1ccc(C[NH3+])cn1 Fragment 2: [5*]N1C[C@H]2CCC[NH+]2C[C@@H]1C ### Response: C[C@H]1C[NH+]2CCC[C@@H]2CN1Cc1ccc(C[NH3+])cn1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1cc(C(N(C)C)=O)cnc1N1C[C@H]([C@H](c2ccc3c(c2)cccc3)CC1)O ### Response: CN(C)C(=O)c1ccc(N2CC[C@@H](c3ccc4ccccc4c3)[C@H](O)C2)nc1
functional_group
### Instruction: Does the molecule contain a aldehyde group? C#CCNC(=O)N[C@H](C)c1cc(OC)c(OC)c(OC)c1 ### Response: No
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Cc1cnc([C@@H](NC(=O)N(C)Cc2nccn2C(F)F)C2CC2)s1 ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]Cc1ccc(Cl)s1 Fragment 2: [11*]Sc1ccc(C)cc1N ### Response: Cc1ccc(SCc2ccc(Cl)s2)c(N)c1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1cccc(NC(=O)C2CCN(C(=O)NC[C@@H]3CCCO3)CC2)n1 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. N(c1cc(CC[NH+]2CCCC2)ccc1)Cc1ccsc1 ### Response: c1cc(CC[NH+]2CCCC2)cc(NCc2ccsc2)c1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCNC(=O)NC1(C(=O)N2CC[C@@H](OCCC(C)C)C2)CCCC1 ### Response: 4
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N(C)C Fragment 2: [1*]C(=O)c1ccc([14*])o1 ### Response: CN(C)S(=O)(=O)c1ccc(NC(=O)c2ccc(-c3ccccc3F)o2)cc1
functional_group
### Instruction: Does the molecule contain a nitrile group? CC(C)OCC(=O)N1CCN(c2nc(-c3ccccc3)nc3c2CCC3)CC1 ### Response: No
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? COc1cc(OC)c2cc(C(=O)N[C@H](C)C(=O)N=c3[nH]c4ccccc4[nH]3)n(C)c2c1 ### Response: Yes
functional_group
### Instruction: Does the molecule contain a sulfonyl group? CC(=O)OC1CC[NH+](Cc2ccc(N3CCCCCC3)cc2)CC1 ### Response: No
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCOc1cc(OCC)c([N+](=O)[O-])nc1Br ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. n1c(scc1CCl)CCCN1C(=O)C(C)(S1(=O)=O)C ### Response: CC1(C)C(=O)N(CCCc2nc(CCl)cs2)S1(=O)=O
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [14*]c1cccs1 Fragment 2: [5*]N(C)C[8*] ### Response: CCc1cnc(CN(C)Cn2nc(-c3cccs3)oc2=S)s1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Cc1cn2c(=O)c(C(=O)N[C@H]3CCC[C@@H](C4CC4)C3)cnc2s1 ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [16*]c1cccc(F)c1 Fragment 2: [16*]c1ccccc1 ### Response: CC[C@H](C(=O)NNC(=O)C[C@H](O)c1cccc(F)c1)c1ccccc1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1cccc2c1n(C)cc2/C=C/C(N1CCCC[C@@H]1CC(OC)=O)=O ### Response: COC(=O)C[C@H]1CCCCN1C(=O)/C=C/c1cn(C)c2ccccc12
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C/[S@](=N\S(=O)(=O)c1cccc2nsnc12)c1ncccc1C(F)(F)F ### Response: 1
functional_group
### Instruction: Does the molecule contain a ester group? Cc1nc(C2CCCC2)sc1-c1nc(-c2ccc(C#N)cn2)no1 ### Response: No
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@H](CC[NH2+][C@@H]1CCCS[C@H]1C)c1ccccc1 ### Response: 4
ring_counting
### Instruction: Count the six-membered rings in the following molecule. O=C(Cc1ccc(N(Cc2ccccc2)C(=O)/C=C/c2ccccc2)cc1)N1CCOCC1 ### Response: 4
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]Cc1cccc([16*])c1 Fragment 2: [16*]c1ccccc1F ### Response: C[NH+](Cc1cccc(-c2ccccc2F)c1)[C@H]1CCC[C@@H]1S(C)(=O)=O
functional_group
### Instruction: Does the molecule contain a amide group? C[C@@H](Sc1nc2ccccc2c(=O)n1Cc1ccco1)C(=O)N[C@H]1CCCC[C@@H]1C ### Response: Yes
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Cn1cc([C@@H]2CCCN2C(=O)C2CCC(n3cccc3)CC2)cn1 ### Response: 3
functional_group
### Instruction: Does the molecule contain a phenol group? N#Cc1cccc(C(=O)NCC(=O)Nc2ccc(F)c(F)c2F)c1 ### Response: No
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? O=C(CCCc1nc(-c2cccnc2)no1)N1CCC[C@@H](Cc2ccccc2)C1 ### Response: Yes
ring_counting
### Instruction: Count the six-membered rings in the following molecule. COc1ccc(/C=C2/N=C([S-])N(C)C2=O)cc1[O-] ### Response: 1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CSCCC(=O)N1C[C@H]2COc3ccccc3C[C@@]2(CO)C1 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*][C@@H](C)CCC=C Fragment 2: [4*]CC(=O)OC ### Response: C=CCC[C@H](C)[NH+]1CCCN(CC(=O)OC)CC1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CCN(CCO)C(=O)N[C@H]1CC(=O)N(C(C)(C)C)C1 ### Response: 0
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [14*]c1cncc([14*])n1 Fragment 2: [9*]n1ccnc1C ### Response: Cc1nccn1-c1cncc(N[C@@H]2CCC[C@H]2CO)n1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]Cc1cccc(N[5*])c1 Fragment 2: [4*]Cc1cccc([16*])c1 ### Response: CN(C)C(=O)Nc1cccc(CNS(=O)(=O)CC2CCC2)c1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@H]1CCC[C@H]1NC(=O)c1cc(C(F)(F)F)ccc1NN ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. O=S(Nc1ccncc1)(c1ccc(cc1)F)=O ### Response: O=S(=O)(Nc1ccncc1)c1ccc(F)cc1
canonicalization
### Instruction: Canonicalize the following SMILES string. CC(C)n1nnnc1SCC(=O)N([C@@H](c1cc(c(F)cc1)F)C)C ### Response: CC(C)n1nnnc1SCC(=O)N(C)[C@H](C)c1ccc(F)c(F)c1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. O=C(CCOc1cccc(Br)c1)N1CCCC1 ### Response: 1
functional_group
### Instruction: Does the molecule contain a amine group? COc1ccc(NS(=O)(=O)c2ccc3c(c2)[C@H]2C=CC[C@@H]2[C@H](c2ccccc2OC)N3)cc1 ### Response: Yes
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CC[NH2+][C@@]1(C(=O)[O-])CCC[C@@H](Sc2ncc(C)cn2)C1 ### Response: 0
canonicalization
### Instruction: Canonicalize the following SMILES string. C1[NH+]([C@H](c2onc(CC)n2)C)CC(C)(C1)C ### Response: CCc1noc([C@H](C)[NH+]2CCC(C)(C)C2)n1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCCN(Cc1nc2cc(Cl)ccc2c(=O)[nH]1)C(=O)c1ccc(C)c(-n2cccc2)c1 ### Response: 3
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(ccccc1NC(NCc1ccnc(c1)OCc1ccccc1)=O)OC ### Response: COc1ccccc1NC(=O)NCc1ccnc(OCc2ccccc2)c1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [16*]c1ccc(OC)cc1 Fragment 2: [16*]c1c(Cl)cccc1Cl ### Response: COc1ccc([C@@H]2[C@H]3C(=O)N(c4c(Cl)cccc4Cl)C(=O)[C@H]3N3CCCN23)cc1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cn1ccc(S(=O)(=O)N2CCO[C@H](CC(=O)[O-])C2)c1 ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1cc(C(=O)N(C)C[C@H](O)C2CC2)c(C)n1[C@@H](C)c1ccccc1 ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N[C@@H]1CCC[C@@H]([15*])C1 Fragment 2: [15*][C@@H]1CCC[C@@H]([15*])C1 ### Response: O=C(NC(CO)CO)N[C@@H]1CCC[C@@H](C(F)(F)F)C1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1cc(ccc1[C@@H]1NC(=S)NC(=C1C(N/N=C/c1cc(ccc1)Br)=O)C)[N+](=O)[O-] ### Response: CC1=C(C(=O)N/N=C/c2cccc(Br)c2)[C@H](c2ccc([N+](=O)[O-])cc2)NC(=S)N1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [9*]n1ccc2nc([14*])ncc2c1=O Fragment 2: [5*]N1CCCC1 ### Response: Cc1cccc(-n2ccc3nc(N4CCCC4)ncc3c2=O)c1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [3*]Oc1ccc([16*])cn1 Fragment 2: [3*]Oc1ccc(Cl)cc1 ### Response: COC(=O)c1ccc(Oc2ccc(Cl)cc2)nc1
functional_group
### Instruction: Does the molecule contain a thiol group? COc1ncnc(N2CC[NH2+][C@H](C)C2)c1[N+](=O)[O-] ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. c1c(ccc(OC)c1)[C@@H]([NH+]1CCC([C@@H](C)[C@H]1C)=O)C ### Response: COc1ccc([C@H](C)[NH+]2CCC(=O)[C@@H](C)[C@H]2C)cc1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1sc(=O)n(CCC(=O)NC2CC(C)(C)[NH2+]C(C)(C)C2)c1C ### Response: 3
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Cc1cc([C@H](C)NS(=O)(=O)c2cc3c(cc2Cl)NC(=O)CO3)c(C)o1 ### Response: 2
functional_group
### Instruction: Does the molecule contain a thiol group? CCOCCS(=O)(=O)[N-]c1cc(Br)ccc1O ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. S1CCC([C@@](C1)(N1CCC[C@H](C(C)C)CC1)C[NH3+])(C)C ### Response: CC(C)[C@H]1CCCN([C@]2(C[NH3+])CSCCC2(C)C)CC1
functional_group
### Instruction: Does the molecule contain a ether group? CCOc1cc(C[NH2+][C@H](C)C23CC4CC(CC(C4)C2)C3)ccc1OC ### Response: Yes
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CCc1nncn1CCNC(=O)N1CCN(c2ccc(OC)cc2)CC1 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*][NH2+]Cc1cc2ccc(C)cc2[nH]c1=O Fragment 2: [4*]C(C)(C)C ### Response: Cc1ccc2cc(C[NH2+]C(C)(C)C)c(=O)[nH]c2c1
functional_group
### Instruction: Does the molecule contain a amide group? CC[NH+]1CCC[C@@H]1CNC(=O)c1nc(COc2c(C)occc2=O)no1 ### Response: Yes
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? O=C(NC[C@@H](O)c1cccc(F)c1)c1cccc(Cl)c1 ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [12*]S(=O)(=O)c1ccc([N+](=O)[O-])cc1OC Fragment 2: [5*]N(CC)CC ### Response: CCN(CC)S(=O)(=O)c1ccc([N+](=O)[O-])cc1OC
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [7*]Cc1ccc(C)o1 Fragment 2: [16*]c1ccc(OC)cc1 ### Response: COc1ccc(C(=O)NNC(=S)NC(=O)/C=C/c2ccc(C)o2)cc1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@@H]1CN(C(=O)[C@@H]2CCCCC[NH2+]2)C[C@@H]1C ### Response: 1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CC(C)(C)OC(=O)NCC(=O)/N=C1/S[C@@H]2CS(=O)(=O)C[C@H]2N1c1cccc(C(F)(F)F)c1 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [6*]C(C)=O Fragment 2: [3*]O[C@@H]1C[C@@H]2[C@H](CC[C@H]3C[C@@H](O)CC[C@@]32C)[C@H]2CC[C@@H]([15*])[C@]21C ### Response: CC(=O)O[C@@H]1C[C@@H]2[C@H](CC[C@H]3C[C@@H](O)CC[C@@]32C)[C@H]2CC[C@@H](C(C)=O)[C@]21C
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Cc1ccc(CN2/C(=N/C(=O)Cc3ccccc3)S[C@H]3CS(=O)(=O)C[C@H]32)cc1 ### Response: 2
functional_group
### Instruction: Does the molecule contain a halide group? CC(=O)N1CCC[C@H]1C(=O)NC[C@@H]1Cc2cc(Cl)cc(-c3ccc4[nH]ccc4c3)c2O1 ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. c1ccc(cc1-c1ccc2c(c1)CCO2)NC(=O)c1ccoc1C ### Response: Cc1occc1C(=O)Nc1cccc(-c2ccc3c(c2)CCO3)c1
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? CC(C)OCCN1CCc2ccc(Cl)cc2C1 ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C/C(=C\C(=O)NCC(=O)N[C@H]1CCS(=O)(=O)C1)c1ccccc1 ### Response: 4
canonicalization
### Instruction: Canonicalize the following SMILES string. C([S@](=O)[C@H]1C[C@H](CCC1)NC(=O)Nc1ccc(OCC)cc1)C ### Response: CCOc1ccc(NC(=O)N[C@H]2CCC[C@@H]([S@@](=O)CC)C2)cc1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COc1ccccc1-c1noc2ncnc(NC3CCCCC3)c12 ### Response: 1