task
stringclasses
5 values
input
stringlengths
89
339
canonicalization
### Instruction: Canonicalize the following SMILES string. C(CC)c1c(C)sc(C(=O)NOCC)c1 ### Response: CCCc1cc(C(=O)NOCC)sc1C
canonicalization
### Instruction: Canonicalize the following SMILES string. C1CCCC2(C[C@H](CCO2)[NH2+]CCC(F)(F)F)C1 ### Response: FC(F)(F)CC[NH2+][C@H]1CCOC2(CCCCC2)C1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. C[C@@H](C(=O)NC(=O)NCC(F)(F)F)N1CCSC(C)(C)C1 ### Response: 0
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? C[C@H](Cc1ccccc1F)NC(=O)C(=O)Nc1ccc(Cl)cc1F ### Response: Yes
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CC(=O)Nc1cccc(NC(=O)C(=O)NCC[NH+]2CCCC[C@@H]2C)c1C ### Response: 0
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCOC1CCN(/C(NCc2cccc(N(C)C)c2)=[NH+]\C)CC1 ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COCCn1cc(NC(=O)NC[C@@H]2CCN(c3ccc(F)c(F)c3)C2)cn1 ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CSCC[C@](C)(O)CNC(=O)Nc1ccccc1C ### Response: 4
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COCCOc1ccc(C(=O)N2CCC[C@@H](c3ccn[nH]3)C2)cc1 ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. c1ccc2c(C(N(CCC(NCc3c(cccc3)OC)=O)[C@@]3(C)CCC(N23)=O)=O)c1 ### Response: COc1ccccc1CNC(=O)CCN1C(=O)c2ccccc2N2C(=O)CC[C@]12C
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COCCCN1C(=O)C([O-])=C(C(=O)c2ccccc2)[C@@H]1c1ccccc1 ### Response: 3
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [16*]c1ccccc1C Fragment 2: [14*]c1noc([14*])n1 ### Response: Cc1ccccc1-c1cc(O)c2c(c1)CN(c1nc(-c3ccccc3)no1)CCO2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCOc1cccc(CN2CC[NH+](C[C@H]3CCOC3)CC2)c1 ### Response: 2
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Cc1ccc(N2CCC(C(=O)NCc3ccc[nH]3)CC2)[nH+]c1 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1ccc(NC(=O)C(=O)Nc2cc(F)ccc2F)cc1N1CCCC1=O ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C=CCN1C(=O)N[C@@H](c2csc(Br)c2)C(C(=O)OCC)=C1C ### Response: 3
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [16*]c1cc(F)ccc1F Fragment 2: [5*]N1CCc2cc(F)ccc2C1 ### Response: O=C([C@@H]1C[C@@H]1c1cc(F)ccc1F)N1CCc2cc(F)ccc2C1
canonicalization
### Instruction: Canonicalize the following SMILES string. CCc1nsc(n1)Oc1c(Cl)cc(C=O)c(Cl)c1 ### Response: CCc1nsc(Oc2cc(Cl)c(C=O)cc2Cl)n1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [8*]Cc1c(C)nc(S[11*])[nH]c1=O Fragment 2: [8*]Cc1ccccc1 ### Response: CCc1ccc(NC(=O)CSc2nc(C)c(Cc3ccccc3)c(=O)[nH]2)cc1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CC(C)C[C@H](C)CC(=O)N1CCC(n2c(=O)[nH]c3ccccc32)CC1 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. C1CC[C@@H](NC(=O)Cc2ccc(-c3ccccc3)cc2)[C@H](C1)N1C(=O)SCC1=O ### Response: O=C(Cc1ccc(-c2ccccc2)cc1)N[C@@H]1CCCC[C@@H]1N1C(=O)CSC1=O
canonicalization
### Instruction: Canonicalize the following SMILES string. C1C[C@@H](C=C1c1ccc(Cl)cc1)OC([C@@H]1Cc2c(cn[nH]2)CC1)=O ### Response: O=C(O[C@@H]1C=C(c2ccc(Cl)cc2)CC1)[C@H]1CCc2cn[nH]c2C1
functional_group
### Instruction: Does the molecule contain a amine group? CCN[C@@H](c1cnccn1)C1([NH+](C)C)CCCC1 ### Response: Yes
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Cc1cc(C(=O)N2CCC[C@@H]2[C@H]2CCC[C@@H]2O)ccc1F ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C(CCn1ccc2ccccc21)N1CCc2ccc([N+](=O)[O-])cc2C1 ### Response: 3
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)[C@H](C)O[3*] Fragment 2: [5*]Nc1ccc(CC)cc1 ### Response: CCc1ccc(NC(=O)[C@H](C)OC(=O)c2cnc(C)cn2)cc1
canonicalization
### Instruction: Canonicalize the following SMILES string. N1(CCN(C(C(C)C)=O)CC1)c1nc(nc(c1)OCCC)C ### Response: CCCOc1cc(N2CCN(C(=O)C(C)C)CC2)nc(C)n1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [16*]c1ccc(Cl)cc1 Fragment 2: [1*]C(=O)[C@H](C)S(=O)(=O)c1ccc(C)cc1C ### Response: Cc1ccc(S(=O)(=O)[C@@H](C)C(=O)N[C@H](C)c2ccc(Cl)cc2)c(C)c1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]Nc1cnn(C[8*])c1 Fragment 2: [8*]Cc1ccc(C)cc1 ### Response: Cc1ccc(Cn2cc(NC(=O)c3cccnc3)cn2)cc1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? S=c1[nH]c(-c2ccccc2)c(-c2ccccc2)[nH]1 ### Response: 0
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCc1nn(C)cc1CNC(=O)N1CC[C@@H](S(=O)(=O)NC(C)C)C1 ### Response: 3
ring_counting
### Instruction: Count the five-membered rings in the following molecule. COC[C@H]([NH2+][C@H](C)c1cc2c(cc1[N+](=O)[O-])OCO2)C1CC1 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. O=C(OCC)[C@@](Nc1cc(F)ccc1)(NC(C)=O)C(F)(F)F ### Response: CCOC(=O)[C@](NC(C)=O)(Nc1cccc(F)c1)C(F)(F)F
functional_group
### Instruction: Does the molecule contain a phenol group? CCc1nc(-c2ccc(N3CCN(C(=O)[C@@H](C)NC(=O)c4ccccc4)CC3)cc2)no1 ### Response: No
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC(=O)N1CC[C@@H](NC(=O)[C@@H](O)c2ccccc2)c2ccccc21 ### Response: 2
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CCCCN(Cc1ccco1)C(=O)Cn1ncc2c([nH]c3ccccc32)c1=O ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCOc1cc2c(cc1CNC(=O)CCc1ccc(F)cc1)O[C@@H](C)C2 ### Response: 3
ring_counting
### Instruction: Count the six-membered rings in the following molecule. O=C1O[C@H](O)c2cccc3ccc4cccc1c4c23 ### Response: 3
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [9*]n1ccc2ccccc21 Fragment 2: [1*]C(=O)[C@@H]1C=C(C[8*])N=N1 ### Response: COC[C@@H]1CCCN(C(=O)[C@@H]2C=C(Cn3ccc4ccccc43)N=N2)C1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CC(C)(O)CNC(=O)c1c(F)ccc([N+](=O)[O-])c1F ### Response: 0
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [8*]COC Fragment 2: [5*]N1CCO[C@@H]([13*])C1 ### Response: COC[C@H]1CN(C(=O)N[C@H]2CCN(c3c(F)cccc3F)C2)CCO1
canonicalization
### Instruction: Canonicalize the following SMILES string. O=C(N[C@H](C)CC)[C@@H](C)N1CC(C)(C)OCC1 ### Response: CC[C@@H](C)NC(=O)[C@@H](C)N1CCOC(C)(C)C1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [3*]Oc1cc([16*])ccc1[16*] Fragment 2: [3*]OCC ### Response: CCOc1ccc([C@@H]2Nc3ccccc3NC3=C2C(=O)CC(C)(C)C3)cc1OC(C)=O
functional_group
### Instruction: Does the molecule contain a nitrile group? C[C@H](Cn1cc[nH+]c1)NC(=O)NNC(=O)c1cccc2ccccc12 ### Response: No
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CC(C)CCN(C(=O)NCc1ccc(N2CCOCC2)cc1)C1CC1 ### Response: 0
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CC1=NC(C)=C(C(=O)N2CCCCC2)[C@H]1S(=O)(=O)N1CCC(C(=O)Nc2ccc(C#N)cc2)CC1 ### Response: 3
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [8*]COC Fragment 2: [5*][N-]c1ccccc1[16*] ### Response: COCc1ccccc1[N-]S(=O)(=O)c1cc(C(=O)N(C)C)n(C)c1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCO[C@H]1CCCN(C(=O)N[C@H]2CCc3c(Br)cccc32)C1 ### Response: 2
functional_group
### Instruction: Does the molecule contain a ketone group? CC(C)(C)OC(=O)N1CC[C@H]([S@@](=O)c2cccc(Cl)c2Cl)C1 ### Response: No
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@@H](Cc1ccc(O)cc1)N(C)C(=O)Nc1ccc([N+](=O)[O-])c(Cl)c1 ### Response: 3
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]Cc1csc(Br)c1 Fragment 2: [16*]c1cc(C)ccc1OC ### Response: COc1ccc(C)cc1[C@@H](C)[NH2+]Cc1csc(Br)c1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@@H]1C[C@@]2(CS1)CC(=O)NC(=O)[C@@H]2c1ccc(F)cc1 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. n1c2c(cccc2)c(=O)[nH]c1[C@H](N1CCN(S(=O)(c2c(c(C)c(c(c2C)C)C)C)=O)CC1)C ### Response: Cc1c(C)c(C)c(S(=O)(=O)N2CCN([C@H](C)c3nc4ccccc4c(=O)[nH]3)CC2)c(C)c1C
ring_counting
### Instruction: Count the six-membered rings in the following molecule. C[NH2+][C@@]1(CO)CC[C@H](n2ccc(C(F)(F)F)n2)C1 ### Response: 0
functional_group
### Instruction: Does the molecule contain a amide group? N#Cc1ccc(NC[C@@H](O)COc2ccc(F)c(F)c2)nc1 ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. c1ccc(cc1/C=C(/C(c1ccc(cc1)CCC)=O)C#N)[N+](=O)[O-] ### Response: CCCc1ccc(C(=O)/C(C#N)=C/c2cccc([N+](=O)[O-])c2)cc1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [10*]N1C(=O)[C@H]2CC(Cl)=CC[C@H]2C1=O Fragment 2: [5*]NCc1ccccc1 ### Response: O=C(CCN1C(=O)[C@H]2CC(Cl)=CC[C@H]2C1=O)NCc1ccccc1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COCc1nc2cc(NCc3ccc(N4CCCCC4)cc3)ccc2o1 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(C)ccc(-n2nc3c(c2NC(=O)c2oc(Br)cc2)CSC3)cc1C ### Response: Cc1ccc(-n2nc3c(c2NC(=O)c2ccc(Br)o2)CSC3)cc1C
functional_group
### Instruction: Does the molecule contain a ether group? Cn1cc(C(=O)C[C@H]2CCC[NH+]2CCOc2ccc(F)cc2Cl)cn1 ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. n12c(Sc3ccc(C#N)c(c3)[N+](=O)[O-])nnc2cccc1 ### Response: N#Cc1ccc(Sc2nnc3ccccn23)cc1[N+](=O)[O-]
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(OC)cc(N[C@@H]2CCOC3(CCCC3)C2)c(cc1)F ### Response: COc1ccc(F)c(N[C@@H]2CCOC3(CCCC3)C2)c1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCC[C@H]([NH3+])C[S@@](=O)Cc1cc(C)cc(C)c1 ### Response: 5
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COc1ccc(-c2cn3c4c(=O)n(C)c(=O)n(C)c4nc3n2C2CCCCC2)cc1 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1nn(C)cc1CCC(=O)N1CC[C@H](C(N)=O)c2ccccc21 ### Response: 3
canonicalization
### Instruction: Canonicalize the following SMILES string. c1c(nccc1)C(Nc1sc2CN(CCc2n1)Cc1ccc([N+](=O)[O-])cc1)=O ### Response: O=C(Nc1nc2c(s1)CN(Cc1ccc([N+](=O)[O-])cc1)CC2)c1ccccn1
functional_group
### Instruction: Does the molecule contain a amine group? CCOc1ccc(NC(=O)c2cc(Cl)nc([O-])n2)cc1 ### Response: No
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Cc1ccccc1C1=C[C@H]([C@H]2NC(c3cccc(F)c3)=NO2)N=N1 ### Response: 2
ring_counting
### Instruction: Count the six-membered rings in the following molecule. C[C@H](C(=O)Nc1cccc(F)c1)N1CCN(Cc2cscn2)CC1 ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)C1CCN(C([1*])=O)CC1 Fragment 2: [1*]C(=O)C1CCN([5*])CC1 ### Response: C[C@H]1CCC[C@@H](N(C)C(=O)C2CCN(C(=O)Nc3ccccc3)CC2)C1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCOC(=O)c1cc2ccsc2n1CC(=O)Nc1c(C)cc(C)cc1C ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(CC(=O)Nc2[nH]ncc2N)cc(ccc1)Br ### Response: Nc1cn[nH]c1NC(=O)Cc1cccc(Br)c1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCOc1cc(/C=C2/C(=O)N(c3ccc(Cl)cc3)N=C2C)cc(Cl)c1O ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C/C(=N/NC(=O)CCC(=O)Nc1cccc(Cl)c1C)c1ccc(Cl)cc1 ### Response: 4
functional_group
### Instruction: Does the molecule contain a sulfonyl group? O=S(=O)(c1ccc(Nc2ccc(-c3ccccc3F)nn2)cc1)N1CCCCC1 ### Response: Yes
ring_counting
### Instruction: Count the six-membered rings in the following molecule. C[NH+](C)C[C@@](C)(O)CNC(=O)NCC(C)(C)c1ccncc1 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCc1ccccc1NC(=O)CN1CCN(C(=O)[C@H](C)n2cncn2)CC1 ### Response: 3
canonicalization
### Instruction: Canonicalize the following SMILES string. c1cc(C(NCC(N2CCN(C(=O)c3cnccc3)CC2)=O)=O)sc1 ### Response: O=C(NCC(=O)N1CCN(C(=O)c2cccnc2)CC1)c1cccs1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. COc1ccc(NS(=O)(=O)c2cccc(C(=O)NC34CC5CC(CC(C5)C3)C4)c2)cc1 ### Response: 0
functional_group
### Instruction: Does the molecule contain a phenol group? OCc1cc2ccccc2nc1N1CC[C@@H]([N+]2=CCCC2)C1 ### Response: No
functional_group
### Instruction: Does the molecule contain a ether group? Cc1nc2ccc(C(=O)N(C)C3CCCCC3)cc2nc1C ### Response: No
functional_group
### Instruction: Does the molecule contain a ether group? Cc1cccc([C@@H](CC(F)(F)F)C(=O)[O-])c1 ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. c1cc(cc(c1)-c1csc(n1)NC(=O)CCOCC(F)(F)F)F ### Response: O=C(CCOCC(F)(F)F)Nc1nc(-c2cccc(F)c2)cs1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(cc2ccc(C)c(C)c2[nH+]c1NCCNC(C12CC3CC(C1)CC(C3)C2)=O)C#N ### Response: Cc1ccc2cc(C#N)c(NCCNC(=O)C34CC5CC(CC(C5)C3)C4)[nH+]c2c1C
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N1C[C@@H](C)Oc2ccc(C)cc21 Fragment 2: [1*]C(=O)c1ccc([14*])nc1 ### Response: Cc1ccc2c(c1)N(C(=O)c1ccc(-n3ccnc3)nc1)C[C@@H](C)O2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@@H](c1ccco1)N(C(=O)Nc1c(F)cc(F)cc1F)C1CC1 ### Response: 2
functional_group
### Instruction: Does the molecule contain a nitro group? C[C@H]1CCc2c(C(=O)NCc3ccc(S(N)(=O)=O)cc3)csc2C1 ### Response: No
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCOC(=O)c1c(SC)n[nH]c1N ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]NC[C@@H](C)C[C@@H](C)O Fragment 2: [16*]c1ccc(CC)cc1 ### Response: CCc1ccc([C@H](C)NC(=O)NC[C@@H](C)C[C@@H](C)O)cc1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [3*]OCc1ccc(Cl)cc1Cl Fragment 2: [1*]C(=O)c1cc(C)nc2c1c(C)nn2C ### Response: Cc1cc(C(=O)OCc2ccc(Cl)cc2Cl)c2c(C)nn(C)c2n1
functional_group
### Instruction: Does the molecule contain a amide group? CC[C@H]1c2ccsc2CCN1C(=O)/C=C/c1cc(OC)c(OC)c(OC)c1 ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*][NH+]1CCCC[C@@H]1[13*] Fragment 2: [15*][C@H]1CC[C@H](CC)C1 ### Response: CC[C@H]1CC[C@H]([NH+]2CCCC[C@@H]2[C@H]2CNC(=O)C2)C1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. C1=C[C@H]2C[C@@H]1C[C@H]2CN1CC[NH+](C2CCCCCC2)CC1 ### Response: 2
functional_group
### Instruction: Does the molecule contain a carboxyl group? COc1ccc(/C=C2\NC(=S)N(Cc3ccccc3Cl)C2=O)cc1O ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. O=C(CNC(NC)=O)N1[C@@H](c2ccc(OCC)cc2)CCC1 ### Response: CCOc1ccc([C@H]2CCCN2C(=O)CNC(=O)NC)cc1
functional_group
### Instruction: Does the molecule contain a halide group? Cc1ccc(C)c2nc3sc(C(=O)Nc4ccc5c(c4)OCO5)c(N)c3cc12 ### Response: No
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@H](NC(=O)CSC(C)(C)C)c1ccccc1Br ### Response: 3
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCS(=O)(=O)NCCSc1cc(C)c2ccccc2n1 ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COc1ccc(F)cc1NC(=O)N1CCO[C@H](c2ccc(C)o2)C1 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. C(NCCC)(=O)Nc1ccccc1C(C)C ### Response: CCCNC(=O)Nc1ccccc1C(C)C