task
stringclasses
5 values
input
stringlengths
89
339
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C([O-])[C@H]1CCC[NH+]1CCn1ccnc1 ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. c1cc(ccc1/C=N\NC(=O)c1cc(n[nH]1)C(C)(C)C)O ### Response: CC(C)(C)c1cc(C(=O)N/N=C\c2ccc(O)cc2)[nH]n1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. O=C([C@H]1CCOc2ccccc21)N1CCC[C@H](n2cncn2)C1 ### Response: 3
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [9*]n1nc([14*])cc1C Fragment 2: [15*][C@H]1CCS(=O)(=O)C1 ### Response: Cc1cc(C(=O)[O-])nn1[C@H]1CCS(=O)(=O)C1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)CN([5*])[5*] Fragment 2: [5*]N([5*])CC(F)(F)F ### Response: Cc1ccc(-c2n[nH]cc2CN(CC(=O)N(C)C)CC(F)(F)F)cc1
functional_group
### Instruction: Does the molecule contain a ester group? O=C(N[C@@H](CO)c1ccco1)c1cc(Cl)ccc1OC1CCCC1 ### Response: No
functional_group
### Instruction: Does the molecule contain a nitrile group? CSc1ccc(C(=O)CN2C(=O)c3ccccc3C2=O)cc1NC(C)=O ### Response: No
functional_group
### Instruction: Does the molecule contain a carboxyl group? O=C(Oc1cccc(N2C(=O)[C@H]3CC=CC[C@@H]3C2=O)c1)c1ccc(Cl)cc1Cl ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. C(COc1ccc(cc1Cl)Cl)(=O)Nc1oc(-c2ccc(cc2)C(F)(F)F)nn1 ### Response: O=C(COc1ccc(Cl)cc1Cl)Nc1nnc(-c2ccc(C(F)(F)F)cc2)o1
canonicalization
### Instruction: Canonicalize the following SMILES string. N1(C(c2ccc(C)cc2C1=O)=O)[C@@H](C)C(N(C)CCCC)=O ### Response: CCCCN(C)C(=O)[C@H](C)N1C(=O)c2ccc(C)cc2C1=O
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COc1ccc(S(=O)(=O)NC2CCN(C(=O)[C@H]3CC(=O)N(c4cccc(Cl)c4)C3)CC2)cc1 ### Response: 1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Cc1noc(CNCc2c[nH+]cn2C2CC2)n1 ### Response: 0
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1cccc(N2C(=O)CS[C@]23C(=O)N(CC(=O)NCc2ccccc2Cl)c2ccccc23)c1 ### Response: 2
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CCOc1ccc([N-]S(=O)(=O)/C=C/c2ccccc2)cc1CO ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N[C@H]1C[C@H]2CCCc3cccc1c32 Fragment 2: [1*]C(=O)COC ### Response: COCC(=O)N[C@H]1C[C@H]2CCCc3cccc1c32
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Nc1nc(CC(=O)N2CCC[C@@H](c3[nH]ncc3-c3ccccc3)C2)cc(=O)[nH]1 ### Response: 1
functional_group
### Instruction: Does the molecule contain a amine group? C=C(C)C[NH+]1CCN(c2cc(C)nc3c(-c4ccccc4Cl)c(C)nn23)CC1 ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. c1cc(C(=O)NC(Nc2cc(ccc2OC)-c2oc(CO)cc2)=S)sc1 ### Response: COc1ccc(-c2ccc(CO)o2)cc1NC(=S)NC(=O)c1cccs1
canonicalization
### Instruction: Canonicalize the following SMILES string. O=C1C(S(=O)(N1C[C@@H](CBr)C(C)(C)C)=O)(C)C ### Response: CC(C)(C)[C@H](CBr)CN1C(=O)C(C)(C)S1(=O)=O
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [3*]Oc1cccc(C#N)c1 Fragment 2: [1*]C(=O)[C@H](C)O[3*] ### Response: C[C@H](Oc1cccc(C#N)c1)C(=O)N1CCc2c([nH]c3ccccc23)C1
functional_group
### Instruction: Does the molecule contain a thiol group? O=C(NCc1ccc(Br)cc1F)NC1CCOCC1 ### Response: No
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)N1CC=C(c2cc(C)cc(C)c2)CC1 Fragment 2: [1*]C(=O)N[5*] ### Response: Cc1cc(C)cc(C2=CCN(C(=O)N[C@@H]3CCS(=O)(=O)C3)CC2)c1
functional_group
### Instruction: Does the molecule contain a halide group? CCOC(=O)O[C@@H]1C=CC(=O)[C@@](C)(c2ccc(-c3ccccc3)cc2)O1 ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. O=S(Cc1c(cccc1)F)(NCc1nnn(c1)-c1ccccc1)=O ### Response: O=S(=O)(Cc1ccccc1F)NCc1cn(-c2ccccc2)nn1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CCC(=O)OCC1=C(c2ccc(Cl)cc2)CSC1=N ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCC(=O)Nc1cc(F)c(F)cc1Cl ### Response: 3
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@@H]1C[NH+](Cc2ccccc2)CCCN1C(=O)NCCS(C)(=O)=O ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@@H](NC[C@@H](O)c1ccccc1)c1ccncc1 ### Response: 2
ring_counting
### Instruction: Count the six-membered rings in the following molecule. O=C(CCCn1ccnn1)N1CCO[C@@H](c2cccc(OC(F)F)c2)C1 ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N1CCCCCCC1 Fragment 2: [1*]C(=O)c1ccc2c(=O)[nH]c([S-])nc2c1 ### Response: O=C(c1ccc2c(=O)[nH]c([S-])nc2c1)N1CCCCCCC1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. COc1cc2nc(C)n(CCNC(=O)c3cccc4[nH]ccc34)c(=O)c2cc1OC ### Response: 3
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [3*]Oc1ccc(Cl)c(Cl)c1 Fragment 2: [1*]C(=O)[C@H](C)O[3*] ### Response: C[C@H](Oc1ccc(Cl)c(Cl)c1)C(=O)NC[C@H]1CCC[C@@H]1O
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CCOC(=O)[C@@]1(NC(=O)[C@H](C)n2cccn2)CCc2ccccc21 ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. FC(Oc1ccccc1NCc1c(cccc1)N1CCOCC1)(F)F ### Response: FC(F)(F)Oc1ccccc1NCc1ccccc1N1CCOCC1
canonicalization
### Instruction: Canonicalize the following SMILES string. C1Oc2c(cc(cc2CC/[NH+]=C(/N)NC2CCCCCC2)F)CO1 ### Response: N/C(NC1CCCCCC1)=[NH+]/CCc1cc(F)cc2c1OCOC2
canonicalization
### Instruction: Canonicalize the following SMILES string. C(C#C[C@@H](O)c1ccccc1)[NH+]1CCCC1 ### Response: O[C@H](C#CC[NH+]1CCCC1)c1ccccc1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*][NH2+]C1CC1 Fragment 2: [13*][C@H]1CN(C)CCO1 ### Response: CN1CCO[C@@H](c2noc(CC[NH2+]C3CC3)n2)C1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. C[C@@H](C(=O)Nc1nccs1)c1ccc(Br)s1 ### Response: 0
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(C)ccc(C)cc1S(N1CCN([C@@H](c2nc(nc(n2)N)Nc2ccccc2)C)CC1)(=O)=O ### Response: Cc1ccc(C)c(S(=O)(=O)N2CCN([C@H](C)c3nc(N)nc(Nc4ccccc4)n3)CC2)c1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C1COc2ccc(NC(=O)C3(c4ccccc4)CCC3)cc2N1 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1nc(CCCN2C(=O)N(CC(N)=O)C(C)(C)C2=O)cs1 ### Response: 3
functional_group
### Instruction: Does the molecule contain a sulfonyl group? C[C@@H]1CN(C(=O)c2cc(F)c(Cl)cc2Cl)C[C@@H](C)O1 ### Response: No
ring_counting
### Instruction: Count the six-membered rings in the following molecule. COc1ccc(-c2csc(NC(=O)Nc3ccc(F)cc3)n2)cc1OC ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. C1CC[NH+](C[C@@H](NC(c2nc(C3CC3)[nH]n2)=O)C)CC1 ### Response: C[C@@H](C[NH+]1CCCCC1)NC(=O)c1n[nH]c(C2CC2)n1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [15*]C1CC1 Fragment 2: [5*]NCC([8*])[8*] ### Response: CC(=O)N[C@@H](C(=O)NCC(C1CC1)C1CC1)C(C)C
canonicalization
### Instruction: Canonicalize the following SMILES string. C1N(CCN(C1)C(=O)C(N1CCCC1)=O)C(C[NH+]1C[C@H](C)C[C@H](C)C1)=O ### Response: C[C@@H]1C[C@H](C)C[NH+](CC(=O)N2CCN(C(=O)C(=O)N3CCCC3)CC2)C1
canonicalization
### Instruction: Canonicalize the following SMILES string. C1(C(=O)Nc2cnn(c2)CC)CCN(CC1)C(=O)c1ccc(cc1)[N+]([O-])=O ### Response: CCn1cc(NC(=O)C2CCN(C(=O)c3ccc([N+](=O)[O-])cc3)CC2)cn1
canonicalization
### Instruction: Canonicalize the following SMILES string. C(NC(=O)CNC(=O)c1cccc(c1)Br)C1(CCCC1)c1ccccc1 ### Response: O=C(CNC(=O)c1cccc(Br)c1)NCC1(c2ccccc2)CCCC1
canonicalization
### Instruction: Canonicalize the following SMILES string. C(C(=O)N1CCC[C@@H](NC(=O)C)C1)Sc1ncc(cc1)C ### Response: CC(=O)N[C@@H]1CCCN(C(=O)CSc2ccc(C)cn2)C1
canonicalization
### Instruction: Canonicalize the following SMILES string. C(COC(=O)N[C@@H]1CS(=O)(CC1)=O)[NH+](CC)CC ### Response: CC[NH+](CC)CCOC(=O)N[C@H]1CCS(=O)(=O)C1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]Nc1cccc(OC)c1 Fragment 2: [1*]C(=O)[C@@H](N[5*])C(C)C ### Response: COc1cccc(NC(=O)[C@@H](NC(=O)c2ccco2)C(C)C)c1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N[C@H]([8*])CC Fragment 2: [4*][C@H]([8*])CC ### Response: CC[C@H]1CCC[C@H](NC(=O)N[C@@H](CC)c2cccc(S(N)(=O)=O)c2)C1
functional_group
### Instruction: Does the molecule contain a halide group? CCOc1ccc([C@@H]2CCCN2C(=O)CCCn2c(=O)oc3ccccc32)cc1 ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. N1(c2c(C[NH+]3[C@H](CC)C(=O)NCC3)cccc2CC1)C(=O)OC(C)(C)C ### Response: CC[C@@H]1C(=O)NCC[NH+]1Cc1cccc2c1N(C(=O)OC(C)(C)C)CC2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCN[C@H](Cc1ccc(C(F)(F)F)cc1)C(C)(C)[NH+](C)C ### Response: 4
canonicalization
### Instruction: Canonicalize the following SMILES string. c1c(F)c(F)c(cc1C(=O)N1CCC(=O)N(CC(C)C)CC1)F ### Response: CC(C)CN1CCN(C(=O)c2cc(F)c(F)c(F)c2)CCC1=O
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CC(C)(C)c1ncc([N-]S(=O)(=O)c2cccc(C(=O)N3CCCC3)c2)cn1 ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COc1ccc(OCCc2cc([C@H]3CCN(C(=O)c4cccnc4)C3)n[nH]2)cc1 ### Response: 2
ring_counting
### Instruction: Count the five-membered rings in the following molecule. C/[NH+]=C(/NCCOC)N1CCN(c2ccc(F)cc2)CC1 ### Response: 0
canonicalization
### Instruction: Canonicalize the following SMILES string. [O-][N+](c1ccccc1Sc1nccc(c1)C#N)=O ### Response: N#Cc1ccnc(Sc2ccccc2[N+](=O)[O-])c1
functional_group
### Instruction: Does the molecule contain a hydroxyl group? Cc1ccc(CN2CCOC3(CCC3)C2)c(C)c1 ### Response: No
functional_group
### Instruction: Does the molecule contain a amine group? CC(C)N(CC(C)(C)O)C(=O)N[C@@H](c1cccc(C(F)(F)F)c1)C1CC1 ### Response: No
functional_group
### Instruction: Does the molecule contain a amide group? O=C(COc1nncc2ccccc12)NCc1ccc(Cl)cc1 ### Response: Yes
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CCOc1cc2c(cc1Cn1c(=O)oc3cccnc31)O[C@@H](C)C2 ### Response: 2
functional_group
### Instruction: Does the molecule contain a ester group? O=c1c2cnn(-c3ccc(Cl)cc3)c2ncn1Cc1cccc2ccccc12 ### Response: No
ring_counting
### Instruction: Count the five-membered rings in the following molecule. O=C(CCC(=O)N1CCOCC1)O[C@@H](C1CCCCC1)C(F)(F)F ### Response: 0
ring_counting
### Instruction: Count the six-membered rings in the following molecule. C[C@@H]1CCCN(C(=O)NCc2ccc(N3CCOCC3)cc2)CC1 ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. c1cc(ccc1)CN(CCC(=O)N)C(=O)Cc1c2c(ccc1)cccc2 ### Response: NC(=O)CCN(Cc1ccccc1)C(=O)Cc1cccc2ccccc12
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [16*]c1cccnc1 Fragment 2: [14*]c1ccc(C#N)c(=O)[nH]1 ### Response: N#Cc1ccc(-c2cccnc2)[nH]c1=O
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? CC[C@@H](NC(=O)c1ccc(C)c(F)c1)c1nc(C(F)(F)F)cs1 ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. Clc1c(cccc1)CSc1ccccc1NC(CSc1n(N)c(C)nn1)=O ### Response: Cc1nnc(SCC(=O)Nc2ccccc2SCc2ccccc2Cl)n1N
functional_group
### Instruction: Does the molecule contain a amine group? CC[C@@H](C)NC(=O)c1ccc2c(=O)n(C(C)C)c3nn(Cc4c(F)cccc4Cl)c(=O)n3c2c1 ### Response: No
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CC[C@](C)(C(=O)NC1CCCCC1)N(C)C(=O)CNC(=O)c1ccccc1 ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COc1ccc(-n2c(-c3ccco3)nc3c(cnn3-c3ccccc3Cl)c2=O)cc1 ### Response: 1
functional_group
### Instruction: Does the molecule contain a amine group? O=C(NCC1([NH+]2CCCCC2)CCCCC1)c1cc(F)cc(F)c1 ### Response: No
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N(C)[C@H]([8*])CC Fragment 2: [4*][C@@H](C)c1ccc(Cl)s1 ### Response: CC[C@@H](c1ccncc1)N(C)C(=O)N[C@@H](C)c1ccc(Cl)s1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N1CCC([15*])CC1 Fragment 2: [1*]C(=O)N1CCC([15*])CC1 ### Response: CC[C@@H](CNC(=O)N1CCC(N(CC)S(C)(=O)=O)CC1)c1ccccc1
functional_group
### Instruction: Does the molecule contain a sulfonyl group? CCc1ccc(CC)c(NC(=O)N[C@](C)(CC)CO)c1 ### Response: No
ring_counting
### Instruction: Count the six-membered rings in the following molecule. NC(=O)[C@@H]1CCC[C@@H]1NC(=O)c1ccnc(OC2CCC2)c1 ### Response: 1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. [NH3+]Cc1ccc(C(=O)N2CCC(C(F)(F)F)CC2)o1 ### Response: 1
functional_group
### Instruction: Does the molecule contain a hydroxyl group? COC(=O)C[C@@H]1CN(C2CCCCCCC2)CCO1 ### Response: No
functional_group
### Instruction: Does the molecule contain a amine group? Cc1c(Cl)cccc1-n1ccnc(NCCc2ccccc2)c1=O ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)C[4*] Fragment 2: [5*]Nc1ccc([N+](=O)[O-])cc1 ### Response: CCOc1ccc2nc(SCC(=O)Nc3ccc([N+](=O)[O-])cc3)c(C#N)cc2c1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]CCC Fragment 2: [14*]c1nccn1C ### Response: CCCN(C)c1ccc(C(=O)N[C@H](c2ccc(F)cc2)c2nccn2C)cc1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Cc1ccn(-c2ccc(N3CCN(C(=O)CC(C)C)CC3)nn2)n1 ### Response: 1
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? C[C@]1(O)Cc2[nH]nc(O)c2[C@H](c2cccc([N+](=O)[O-])c2)[C@@H]1C(=O)OCc1ccccc1 ### Response: Yes
functional_group
### Instruction: Does the molecule contain a ketone group? O=C(C1=C([O-])C(=O)N(CC[NH+]2CCCC2)[C@H]1c1cccnc1)C1CC1 ### Response: Yes
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CN(C)[C@@H](C(=O)N(CCO)Cc1cccnc1)c1c(F)cccc1F ### Response: 0
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*][C@H]([8*])CN[5*] Fragment 2: [1*]C(=O)C([1*])=O ### Response: Cn1cccc1[C@H](CNC(=O)C(=O)Nc1ccc(Cl)cc1)[NH+]1CCOCC1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COc1ccc(S(=O)(=O)N2CCC[C@H](C(=O)N(C)Cc3ccccc3N3CCCCC3)C2)cc1 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C(OCc1cc(=O)n2nc(C3CCCCC3)sc2n1)c1ccccc1Br ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [8*][C@@H](O)C1(C[NH3+])CCC(C)(C)CC1 Fragment 2: [15*]C1(C[NH3+])CCC(C)(C)CC1 ### Response: CC1(C)CCC(C[NH3+])([C@H](O)c2cccc(F)c2F)CC1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1ccc(N)c(O[C@H](C(c2c(cc(cc2)C)C)=O)CC)c1 ### Response: CC[C@H](Oc1ccccc1N)C(=O)c1ccc(C)cc1C
functional_group
### Instruction: Does the molecule contain a ketone group? C[C@@H]1[NH2+]CC[C@H]1CN1CC[C@H]([NH+]2CCCC2)C1 ### Response: No
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [8*]CC(=O)[O-] Fragment 2: [4*][C@@H](C)CCC ### Response: CCC[C@H](C)N(C)S(=O)(=O)c1ccc(CC(=O)[O-])s1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*][C@@H](C)c1nnc([14*])o1 Fragment 2: [11*]Sc1ccc(Cl)cc1 ### Response: C[C@H](Sc1ccc(Cl)cc1)c1nnc(-c2ccccc2)o1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)[C@H]1CCCN1[5*] Fragment 2: [4*]Cc1ccccc1 ### Response: CS(=O)(=O)N1CCC[C@@H]1C(=O)OC[C@@H]1CC[NH+](Cc2ccccc2)C1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=S(=O)(Cc1ccccc1)/N=C(\[O-])c1ccc(-n2ccnn2)cc1 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N1CCOCC1 Fragment 2: [5*]NCc1ccc([14*])[nH+]c1 ### Response: Cc1noc2nc(-c3ccccc3F)cc(C(=O)NCc3ccc(N4CCOCC4)[nH+]c3)c12
functional_group
### Instruction: Does the molecule contain a sulfonyl group? C[C@H]1CCc2sc(C(=O)NNC(=O)c3ccc(S(C)(=O)=O)cc3)cc2C1 ### Response: Yes