task
stringclasses
5 values
input
stringlengths
89
339
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N1CCCS1(=O)=O Fragment 2: [5*]Nc1ccc([16*])cc1 ### Response: O=C(Cn1cccn1)Nc1ccc(N2CCCS2(=O)=O)cc1
canonicalization
### Instruction: Canonicalize the following SMILES string. O=C(NCc1nc(-c2ccccc2)cs1)Nc1ccc(OC)cc1 ### Response: COc1ccc(NC(=O)NCc2nc(-c3ccccc3)cs2)cc1
functional_group
### Instruction: Does the molecule contain a halide group? C[C@H](CNC(=O)[C@@H](C)c1cccc(F)c1)Oc1ccccc1F ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [12*]S(=O)(=O)c1ccc(Cl)cc1 Fragment 2: [5*]N1CCN([5*])CC1 ### Response: O=C(c1cccnc1)N1CCN(S(=O)(=O)c2ccc(Cl)cc2)CC1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CC(=O)c1c(C)oc2cc(C)c(NS(=O)(=O)c3cccc4cccnc34)cc12 ### Response: 1
functional_group
### Instruction: Does the molecule contain a halide group? COc1ccc(C)cc1NC(=O)CSc1cc(N2CCN(c3ccc(F)cc3)CC2)ncn1 ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCn1nc(C)c(C[NH+]2C[C@@H](C)CC[C@@H]2C)c1C ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1cc(NC(=O)c2cc3c([nH]c2=O)CCCC3)ccc1C(N)=O ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]Nc1ccc(N[5*])cc1 Fragment 2: [5*]N1CC[C@H](C)[C@@H](O)C1 ### Response: CCC(=O)Nc1ccc(NC(=O)N2CC[C@H](C)[C@@H](O)C2)cc1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COC(C)(C)[C@@H](O)CCS(C)(=O)=O ### Response: 5
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@H]1CC[C@](C#N)([C@H](O)c2ccc3ncccc3c2)C1 ### Response: 1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. C[C@@H](CC(=O)N(C)C1CCS(=O)(=O)CC1)c1ccccc1 ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[NH+](C)[C@H](CNC(=O)CCc1nc2ccccc2s1)c1cccc(F)c1 ### Response: 3
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [8*]CC(F)(F)F Fragment 2: [5*]N[C@](C)(C#N)CC[8*] ### Response: C[C@@](C#N)(CCc1ccccc1)NC(=O)[C@@H]1CC(=O)N(CC(F)(F)F)C1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)c1cnn2cc(C[4*])cnc12 Fragment 2: [5*]N[C@H]1CCC[NH2+]C1 ### Response: CC[NH+](CC)Cc1cnc2c(C(=O)N[C@H]3CCC[NH2+]C3)cnn2c1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)c1ccc(Cl)nc1 Fragment 2: [5*]N[C@H]1[C@@H]2CCO[C@@H]2C1(C)C ### Response: CC1(C)[C@@H](NC(=O)c2ccc(Cl)nc2)[C@@H]2CCO[C@@H]21
functional_group
### Instruction: Does the molecule contain a sulfonyl group? C/C=C/CN(c1ncnc2oc(C)nc12)[C@H](C)CC ### Response: No
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)CC[8*] Fragment 2: [14*]c1cc(C)nn1CC ### Response: CCn1nc(C)cc1-c1nnc(CCC(=O)N2CCN(Cc3ccc(F)cc3)CC2)o1
functional_group
### Instruction: Does the molecule contain a nitro group? O=S(=O)(NC[C@@H]1CN2CCCC[C@@H]2CO1)c1c(F)cccc1F ### Response: No
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [7*]C1C(=N)N2N=C(CC(C)C)SC2=NC1=O Fragment 2: [16*]c1ccccc1F ### Response: Cc1cc(/C=C2\C(=N)N3N=C(CC(C)C)SC3=NC2=O)c(C)n1-c1ccccc1F
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CCN(CCC(F)(F)F)Cc1c(Cl)nc2ccccn12 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1cc(CN2CC[NH+](C3CCSCC3)CC2)on1 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C(COc1ccccc1)NN=Cc1ccc(O)cc1 ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N1CCC[C@H]1[13*] Fragment 2: [8*]CC(C)C ### Response: CC(C)Cc1cc(C(=O)N2CCC[C@H]2c2nc3ccccc3s2)n(C)n1
functional_group
### Instruction: Does the molecule contain a ketone group? C[C@@]12C=CC(=O)C=C1CC[C@H]1[C@H]2[C@H](O)C[C@]2(C)[C@H]1CC[C@]2(O)C(=O)COP(=O)([O-])[O-] ### Response: Yes
ring_counting
### Instruction: Count the six-membered rings in the following molecule. COc1cccc(NS(=O)(=O)c2ccc(C)cc2N)c1 ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C(NC1CCCCC1)[C@@H](c1ccncc1)N(C(=O)c1csnn1)c1ccccc1-c1ccccc1 ### Response: 2
functional_group
### Instruction: Does the molecule contain a halide group? O=C(N[C@@H](c1ccccc1)C1CC1)N1CCN(S(=O)(=O)c2cccc(Cl)c2)CC1 ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. c1([C@H](C)N(C(=O)Nc2cc(c(cc2)-n2cnnn2)C)C)occc1 ### Response: Cc1cc(NC(=O)N(C)[C@@H](C)c2ccco2)ccc1-n1cnnn1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CCOc1cc(C)ccc1NC(=O)c1cccs1 ### Response: 1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. O=C(Nc1cccc(Cl)c1)N[C@@H](Cc1ccccc1)C(=O)N1CCc2ccccc21 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. C(CNC([C@@H](C)NC(=O)/C=C/c1ccccc1)=O)C ### Response: CCCNC(=O)[C@@H](C)NC(=O)/C=C/c1ccccc1
canonicalization
### Instruction: Canonicalize the following SMILES string. C1CC[C@H]2[C@@H](CCC[NH+]2C1)CN1CCC(C(=O)N2CCCC2)CC1 ### Response: O=C(C1CCN(C[C@@H]2CCC[NH+]3CCCC[C@@H]23)CC1)N1CCCC1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CN(C)S(=O)(=O)c1ccc(N=[N+]=[N-])c([N+](=O)[O-])c1 ### Response: 0
functional_group
### Instruction: Does the molecule contain a amide group? Cc1ccc(C[NH+](C)CC(C)(CO)CO)c(Br)c1 ### Response: No
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1noc(C)c1[C@H](C)C[NH2+][C@@H]1CCc2cc(Br)ccc2C1 ### Response: 3
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)N[5*] Fragment 2: [1*]C(=O)O[3*] ### Response: COc1cccc2sc(NC(=O)OCC(F)(F)F)nc12
ring_counting
### Instruction: Count the five-membered rings in the following molecule. O=C(c1ccc2c(c1)N(Cc1ccccc1)C(=O)c1ccccc1S2(=O)=O)N1CCc2ccccc21 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [14*]c1ncnc([14*])c1[N+](=O)[O-] Fragment 2: [5*]N1CCN([5*])CC1 ### Response: CN(C)c1ncnc(N2CCN(CCO)CC2)c1[N+](=O)[O-]
functional_group
### Instruction: Does the molecule contain a phenol group? N#Cc1ccc(CN2CC[C@H](C[NH+]3CCCCC3)C2)c(F)c1 ### Response: No
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@@H]1C[C@H](C)CN(C(=O)[C@@H](C)n2sc3ccccc3c2=O)C1 ### Response: 3
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? CCCC(=O)Nc1ccccc1N1CCN(C(=O)c2ccccc2)CC1 ### Response: Yes
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? CC[NH2+][C@@H](Cc1ccc2c(c1)CCC2)[C@H]1CSCCS1 ### Response: Yes
functional_group
### Instruction: Does the molecule contain a nitrile group? O=C(c1ccc(F)cc1)[C@H]1CCCN(C(=O)CCCn2ccnn2)C1 ### Response: No
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)CCS(=O)(=O)[C@H](C)C(C)C Fragment 2: [5*]NC(C)C ### Response: CC(C)NC(=O)CCS(=O)(=O)[C@H](C)C(C)C
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? N#Cc1ccccc1NC(=O)C[NH+]1CCN(Cc2ccccc2)CC1 ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCn1cc(C(=O)N2C[C@H]3CC[C@@H]2C[NH+](CCCc2ccccc2)C3)c(C)n1 ### Response: 3
canonicalization
### Instruction: Canonicalize the following SMILES string. [C@H](C)([C@H]1C(=O)Nc2c(S1)cccc2)C(=O)NCCc1cc(ccc1)C ### Response: Cc1cccc(CCNC(=O)[C@@H](C)[C@@H]2Sc3ccccc3NC2=O)c1
canonicalization
### Instruction: Canonicalize the following SMILES string. C(OC)([C@@H]1CCN(c2ccccc12)C(=O)CSCC(F)(F)F)=O ### Response: COC(=O)[C@@H]1CCN(C(=O)CSCC(F)(F)F)c2ccccc21
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCN1CC(=O)Nc2cc(C(=O)N[C@H](C)c3cccc(Cl)c3)ccc21 ### Response: 2
ring_counting
### Instruction: Count the six-membered rings in the following molecule. COc1cccc(/C=N/c2ccc(S(=O)(=O)[N-]c3nccs3)cc2)c1OC ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? NC(=O)c1cnn2c1N[C@H](c1cccs1)C[C@H]2C(F)(F)F ### Response: 1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Cc1cccc(-c2nnc(SCC(=O)C(C)(C)C)o2)c1 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. C1CCC=C1CC[NH2+][C@@H](CC(=O)Nc1ccc(C)cc1C)C ### Response: Cc1ccc(NC(=O)C[C@@H](C)[NH2+]CCC2=CCCC2)c(C)c1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CN1CCc2cc(CNC(=O)C[C@@H]3C(=O)NCC[NH+]3CCc3ccccc3)ccc21 ### Response: 2
ring_counting
### Instruction: Count the six-membered rings in the following molecule. O=C(NNC(=O)[C@H]1Cc2ccccc2O1)[C@H]1COc2ccc(F)cc2C1 ### Response: 3
ring_counting
### Instruction: Count the six-membered rings in the following molecule. C[C@H](C(=O)[O-])[C@@H](C)[NH+](C)CCC[NH+](C)C ### Response: 0
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)C[4*] Fragment 2: [5*]Nc1cc(OC)ccc1Cl ### Response: COc1ccc(Cl)c(NC(=O)CN2CCC([NH3+])CC2)c1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]CC([6*])=O Fragment 2: [5*]N1C[C@H](C)O[C@@H](C)C1 ### Response: COc1ccc(C(=O)CSC(=O)N2C[C@H](C)O[C@@H](C)C2)cc1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [14*]c1nnc(C)s1 Fragment 2: [8*]Cc1cnn(C)c1 ### Response: Cc1nnc(N2CC[C@@H](Cc3cnn(C)c3)C2)s1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@@H](O)c1cc(F)ccc1OCc1c[nH+]cn1C ### Response: 2
ring_counting
### Instruction: Count the six-membered rings in the following molecule. N#Cc1cccc(S(=O)(=O)NC[C@H](c2ccco2)[NH+]2CCCC2)c1 ### Response: 1
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? Clc1ccc2c(c1)[C@H](NCc1nc(C3CC3)cs1)CCC2 ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]CCCOC Fragment 2: [5*]N1C[C@H](C)C[C@H](C)C1 ### Response: COCCCNc1nc(N)c([N+](=O)[O-])c(N2C[C@H](C)C[C@H](C)C2)n1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [8*]C(C)(C)C(=O)OC Fragment 2: [1*]C(=O)CC[8*] ### Response: COC(=O)C(C)(C)[C@@H]1CCCN(C(=O)CCc2nc(C3CCCC3)no2)C1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C(NCC[C@H]1CCCO1)c1ccc(Cl)cc1O ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. C1CN(c2[nH+]cccc2C(F)(F)F)CCN1C(c1cc(CCl)ccc1)=O ### Response: O=C(c1cccc(CCl)c1)N1CCN(c2[nH+]cccc2C(F)(F)F)CC1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C/[NH+]=C(\NCc1ccc(N2CCOCC2)cc1)NCc1ccsc1 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. C1CC(CCN1C(Cn1cncc1)=O)n1c2c(cccc2)[nH]c1=O ### Response: O=C(Cn1ccnc1)N1CCC(n2c(=O)[nH]c3ccccc32)CC1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC(C)N(C)S(=O)(=O)c1cccc(C(=O)N(C)Cc2c(F)cccc2Cl)c1 ### Response: 3
functional_group
### Instruction: Does the molecule contain a halide group? C[C@@H]1CN(S(=O)(=O)N[C@H](C(=O)[O-])[C@@H](C)O)C[C@@H](C)O1 ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. [C@H]1([C@H](CCCC1)[S@](CC)=O)NS(C)(=O)=O ### Response: CC[S@](=O)[C@H]1CCCC[C@@H]1NS(C)(=O)=O
functional_group
### Instruction: Does the molecule contain a hydroxyl group? COc1ccc(/C=N/NC(=O)COc2ccccc2)cc1C ### Response: No
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [14*]c1cccs1 Fragment 2: [4*]Cc1ccc(F)c([16*])c1 ### Response: C[C@@H](C(N)=O)N1CC[NH+](Cc2ccc(F)c(-c3cccs3)c2)CC1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1ccc(cc1-n1c(c(cc1C)/C=N\NC(c1cccc(-n2c(C)ccc2C)c1)=O)C)[N+](=O)[O-] ### Response: Cc1ccc(C)n1-c1cccc(C(=O)N/N=C\c2cc(C)n(-c3cccc([N+](=O)[O-])c3)c2C)c1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]CCc1ccncc1 Fragment 2: [5*][NH2+][C@@H]1CSCCC1(C)C ### Response: CC1(C)CCSC[C@H]1[NH2+]CCc1ccncc1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. O=[N+]([O-])c1cc(I)cc([N+](=O)[O-])c1 ### Response: 1
functional_group
### Instruction: Does the molecule contain a ester group? CNS(=O)(=O)c1ccc(C(=O)Nc2ccc(-c3cccc(Cl)c3)cc2C)o1 ### Response: No
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N1CCc2ccccc21 Fragment 2: [16*]c1ccc(C#N)cc1 ### Response: N#Cc1ccc(OCC(=O)Nc2ccccc2N2CCc3ccccc32)cc1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(C(NCc2ccc(-c3nc4c(o3)cccn4)cc2)=O)ccc(c([N+](=O)[O-])c1)C ### Response: Cc1ccc(C(=O)NCc2ccc(-c3nc4ncccc4o3)cc2)cc1[N+](=O)[O-]
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1ccc(-c2cc3cccnc3n2CCC(=O)[O-])cn1 ### Response: 3
ring_counting
### Instruction: Count the six-membered rings in the following molecule. COc1cccc([C@@H]2[NH2+][C@@](C)(C(=O)[O-])[C@@H]3C(=O)N(C)C(=O)[C@@H]32)c1O ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]NCc1c(C)ncc2c1CC[NH2+]C2 Fragment 2: [1*]C(=O)c1cc(F)cc(Cl)c1 ### Response: Cc1ncc2c(c1CNC(=O)c1cc(F)cc(Cl)c1)CC[NH2+]C2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1ccccc1NC(=O)C[S@@](=O)[C@H](C)c1ccc(F)c(F)c1 ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)[C@@H](C)SC Fragment 2: [4*]CC1CC1 ### Response: CS[C@H](C)C(=O)Oc1ccc(OCC2CC2)cc1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1cccc(-c2sc(NC(=O)[C@@H]3CN(CC4CC4)C(C3)=O)cn2)c1 ### Response: O=C(Nc1cnc(-c2ccccc2)s1)[C@H]1CC(=O)N(CC2CC2)C1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? N#Cc1ccc(C(=O)NCc2nc3ccccc3s2)cc1 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]NCCC Fragment 2: [4*]CCC ### Response: CCCN[C@]1(C#N)CC[C@@H](N2CCOCC2)C1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CCc1ccsc1CNC(=O)NC[C@@H](c1ccccc1)N1CCOCC1 ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC(C)CS(=O)(=O)c1nc2ccc(NC(=O)c3cc(F)ccc3Cl)cc2s1 ### Response: 3
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [8*]Cn1c(C)cc([16*])c1C Fragment 2: [14*]c1ccco1 ### Response: Cc1cc(C(=O)[C@@H](C)S[C@H](C)[C@@H](C)O)c(C)n1Cc1ccco1
functional_group
### Instruction: Does the molecule contain a thiol group? CCSc1nnc(SCC(=O)Nc2c(C)cc(C)cc2C)s1 ### Response: No
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)C1CC1 Fragment 2: [4*][C@H]([8*])CN[5*] ### Response: O=C(NC[C@@H](c1cccnc1)N1CCN(c2ccccc2)CC1)C1CC1
functional_group
### Instruction: Does the molecule contain a amide group? C=CCNC(=O)[C@@H](C)[NH2+]CC1(c2ccc(Cl)cc2)CCOCC1 ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. c1cc(OCC(N2C[C@H](CCC2)C(F)(F)F)=O)ccc1 ### Response: O=C(COc1ccccc1)N1CCC[C@H](C(F)(F)F)C1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1cc(ccc1CCNC([C@H]1CS[C@]2(C)CCC(N12)=O)=O)F ### Response: C[C@@]12CCC(=O)N1[C@@H](C(=O)NCCc1ccc(F)cc1)CS2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC(C)c1ccc(CN(C)C(=O)[C@H]2CCO[C@@H]2C)cc1 ### Response: 3
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[NH+](CCS(C)(=O)=O)CC(=O)N1CCC[C@H]2CCCC[C@@H]21 ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC1=C(C(=O)Nc2ccccc2)[C@@H](c2cccc(OCc3ccccc3)c2)n2ncnc2N1 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [16*]c1cncc([16*])c1 Fragment 2: [14*]c1cccc(Br)n1 ### Response: COC(=O)c1cncc(-c2cccc(Br)n2)c1