task
stringclasses
5 values
input
stringlengths
89
339
functional_group
### Instruction: Does the molecule contain a ether group? Cc1cccc(C)c1NC(=O)C[NH+]1CCC(OCc2ccc(F)cc2)CC1 ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. Clc1cc(CNC([C@H]2CCCN(C(=O)Cc3c[nH]c4c3cccc4)C2)=O)ccc1 ### Response: O=C(NCc1cccc(Cl)c1)[C@H]1CCCN(C(=O)Cc2c[nH]c3ccccc23)C1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)C(C)(C)CC(C)C Fragment 2: [5*]N[C@H](C)CCC ### Response: CCC[C@@H](C)NC(=O)[C@@H]1CCCN(C(=O)C(C)(C)CC(C)C)C1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. C[C@H](Oc1ccccc1F)C(=O)NCC(=O)N1CCCC1 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1cc(cc([N+](=O)[O-])c1)C(=O)Nc1ccc(O)c(-c2nc3cc(ccc3o2)C)c1 ### Response: Cc1ccc2oc(-c3cc(NC(=O)c4cccc([N+](=O)[O-])c4)ccc3O)nc2c1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1nc(Br)ccc1NC(=O)C(=O)N1C[C@H](C)C[C@@H](C)C1 ### Response: 2
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CN(CCc1cccs1)S(=O)(=O)C[C@@H]1CCC[NH2+]C1 ### Response: 1
functional_group
### Instruction: Does the molecule contain a aldehyde group? Cc1cc(CS(=O)(=O)Nc2ccnn2Cc2cccnc2)no1 ### Response: No
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CCC1(C(=O)NC2CCC(O)CC2)CCCC1 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [9*]n1nc2c3cccc(C)c3ncn2c1=O Fragment 2: [5*]Nc1cccc(Cl)c1 ### Response: Cc1cccc2c1ncn1c(=O)n(CC(=O)Nc3cccc(Cl)c3)nc21
ring_counting
### Instruction: Count the five-membered rings in the following molecule. C=C(Cl)Cc1ccc(C#N)cc1 ### Response: 0
ring_counting
### Instruction: Count the five-membered rings in the following molecule. COCCNC(=O)C(=O)NCc1ccccn1 ### Response: 0
canonicalization
### Instruction: Canonicalize the following SMILES string. c1c(ccc(c1)C(=O)N[C@H](c1ccc(c(F)c1)F)C(=O)OC)NC(C)=O ### Response: COC(=O)[C@H](NC(=O)c1ccc(NC(C)=O)cc1)c1ccc(F)c(F)c1
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? FC(F)n1ccnc1CSCc1nc(-c2cccc(Cl)c2)no1 ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. N(c1ccnn1C(C)C)C(=O)[C@@H]1CN(CCC1)C(=O)Nc1ccccc1 ### Response: CC(C)n1nccc1NC(=O)[C@H]1CCCN(C(=O)Nc2ccccc2)C1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CCOc1cc(NC(=O)c2ccccc2)c(OCC)cc1[N+]#N ### Response: 2
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CN(Cc1ccno1)Cc1c(C(=O)N2CC[NH+](C3CCCCC3)CC2)nc2ccccn12 ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)CS[11*] Fragment 2: [11*]SCc1cccs1 ### Response: CC[C@@](C)(NC(=O)CSCc1cccs1)C(=O)[O-]
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]Nc1ccc([16*])cc1 Fragment 2: [16*]c1ccc(F)cc1 ### Response: C[C@@H](NC(=O)COc1ccc(F)cc1)c1ccc(NC(=O)c2ccncc2)cc1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Cc1cc(NC(=O)N(C)[C@@H](C)c2ccco2)ccc1-n1cnnn1 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1ccc2cccc(C(=O)N[C@@H](c3n[nH]c(C)n3)C(C)C)c2n1 ### Response: 3
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N[C@H]([8*])C Fragment 2: [16*]c1cnn(C)c1C ### Response: CCOc1ccc2c(c1)C=C(C(=O)N[C@@H](C)c1cnn(C)c1C)CO2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [8*]C(C)(C)C Fragment 2: [5*]NCc1n[nH]c(=S)n1CC ### Response: CCn1c(CNC(=O)Nc2ccccc2C(C)(C)C)n[nH]c1=S
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [16*]c1ccc([N+](=O)[O-])nc1 Fragment 2: [5*]N[C@H]1CCCC[C@H]1[S@@](=O)CC ### Response: CC[S@](=O)[C@@H]1CCCC[C@@H]1Nc1ccc([N+](=O)[O-])nc1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Cc1cnn(C[C@@H]2CCCCN2C(=O)[C@H]2CCCO2)c1 ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. C1CC1N(CCC(C)C)C(=O)NCc1ccc(N2CCOCC2)cc1 ### Response: CC(C)CCN(C(=O)NCc1ccc(N2CCOCC2)cc1)C1CC1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CCCn1cnnc1[C@@H](C(=O)OCC)c1cccc(Br)c1 ### Response: 1
functional_group
### Instruction: Does the molecule contain a amide group? COc1cc(C(=O)N[C@H](C)C(=O)N2CCCCC2)nc2ccccc12 ### Response: Yes
ring_counting
### Instruction: Count the six-membered rings in the following molecule. COc1ccc(CC(=O)NNC(=O)COc2ccc3ccccc3c2)cc1 ### Response: 3
functional_group
### Instruction: Does the molecule contain a carboxyl group? COc1ccccc1C(=O)NCC(=O)Nc1cccnc1C ### Response: No
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)c1cnn2c3c(cnc12)CCCCCC3 Fragment 2: [5*]N[C@H]1CCC[C@H](C)[C@H]1C ### Response: C[C@H]1[C@@H](NC(=O)c2cnn3c4c(cnc23)CCCCCC4)CCC[C@@H]1C
functional_group
### Instruction: Does the molecule contain a carboxyl group? CC(C)CN(C(=O)NCc1ccc(C(F)(F)F)cc1)C1CC1 ### Response: No
ring_counting
### Instruction: Count the five-membered rings in the following molecule. O=C(NCCOc1ccc([N+](=O)[O-])cc1)[C@@H]1CCCCN1C(=O)c1ccco1 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@H](c1cccnc1)N(C)C(=O)c1ccc(-n2ccnn2)cc1 ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COc1cc([C@H]2C(C#N)=C(N)OC3=C2C(=O)CCC3)c(OC)c2c1OCO2 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1cc(c(cc1)Cl)-n1ncc2c(n(cnc21)CC(N1CCCCC1)=O)=O ### Response: O=C(Cn1cnc2c(cnn2-c2ccccc2Cl)c1=O)N1CCCCC1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C=CCc1cc(CNC(=O)c2ccco2)cc(OC)c1OC ### Response: 3
ring_counting
### Instruction: Count the six-membered rings in the following molecule. c1ccc(CC[NH2+][C@@H]2CCc3ncnn3C2)nc1 ### Response: 2
functional_group
### Instruction: Does the molecule contain a nitrile group? N#C[C@]1(NC2CC2)CC[C@@H](Sc2n[nH]c(=O)n2C2CC2)C1 ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@H](OC(=O)c1ccccc1I)c1nc2ccccc2c(=O)[nH]1 ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. O=C(NC(=O)NCCc1c(C)cc(cc1)F)CCl ### Response: Cc1cc(F)ccc1CCNC(=O)NC(=O)CCl
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COc1cccc(Cn2c(=O)n(-c3ccccc3)c(=O)c3c2c2cc(C)ccc2n3C)c1 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [8*][C@H](C[NH3+])C(F)(F)F Fragment 2: [10*]N1C[C@H](CC)CC1=O ### Response: CC[C@@H]1CC(=O)N([C@H](C[NH3+])C(F)(F)F)C1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]CCS([12*])(=O)=O Fragment 2: [5*][NH2+]CCS([12*])(=O)=O ### Response: Cc1cc([C@@H]([NH2+]CCS(=O)(=O)N2CCOCC2)C(C)C)c(C)s1
functional_group
### Instruction: Does the molecule contain a carboxyl group? CS(=O)(=O)CS(=O)(=O)OCCCl ### Response: No
ring_counting
### Instruction: Count the five-membered rings in the following molecule. [NH3+]C[C@]1([C@]2(O)CCOC2)COc2ccccc2C1 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. FC([C@H]1C[C@@H]([C@@H]2C[NH+](Cc3cc(C)ccc3OC)CCC2)Nc2ncnn12)(F)F ### Response: COc1ccc(C)cc1C[NH+]1CCC[C@H]([C@@H]2C[C@H](C(F)(F)F)n3ncnc3N2)C1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@@H]1C[C@H](C)CN(C(=O)COC(=O)c2cccc(S(=O)(=O)N3CCc4ccccc43)c2)C1 ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. C([C@@H](C)CN/C(NC[C@@H]1OCCC1)=[NH+]/CC)#N ### Response: CC/[NH+]=C(\NC[C@H]1CCCO1)NC[C@H](C)C#N
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CC[C@@H](C)NC(=O)NCCOc1ncc(C(F)(F)F)cc1Cl ### Response: 0
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CC(C)CN1C(=O)NC(=N)[C@]12CCCC[C@H]2C(C)(C)C ### Response: 1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. C[NH+]1CCC(NC(=O)CN(c2ccc(Oc3ccccc3)cc2)S(C)(=O)=O)CC1 ### Response: 0
functional_group
### Instruction: Does the molecule contain a ether group? O=C(/C=C/c1ccc(-c2ccc(Cl)cc2)o1)c1ccco1 ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. C(N(C[C@@H]1CCCO1)C(=O)NC(C(C)(C)C)=O)c1cc2CCN(c2cc1)C ### Response: CN1CCc2cc(CN(C[C@@H]3CCCO3)C(=O)NC(=O)C(C)(C)C)ccc21
canonicalization
### Instruction: Canonicalize the following SMILES string. C(C)Oc1ccc(cc1)C(=O)N[C@@H](c1ccccc1)c1nc([nH]n1)C ### Response: CCOc1ccc(C(=O)N[C@@H](c2ccccc2)c2n[nH]c(C)n2)cc1
functional_group
### Instruction: Does the molecule contain a ether group? COc1cccc2cc(C[NH+]3CC[C@@H]([N+]4=CCCC4)C3)oc12 ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]Nc1ccc(C)c(F)c1 Fragment 2: [1*]C(=O)c1cccc(Br)c1 ### Response: Cc1ccc(NC(=O)c2cccc(Br)c2)cc1F
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N[C@H]([8*])C Fragment 2: [3*]OC(F)F ### Response: C[C@H](NC(=O)c1ccoc1)c1ccc(OC(F)F)cc1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COc1cc(C[NH+]2CCC(c3nnc(SC[C@H]4CCCO4)n3C)CC2)cc2c1OCO2 ### Response: 1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Cc1nnc([C@@H](C)Oc2cccc(I)c2)o1 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]NS(=O)(=O)c1cc(Cl)ccc1OC Fragment 2: [3*]OCC ### Response: CCOC(=O)c1c(NS(=O)(=O)c2cc(Cl)ccc2OC)sc2c1CCCC2
ring_counting
### Instruction: Count the five-membered rings in the following molecule. C=CCN(CC(=O)[O-])C(=O)c1sc(N)nc1C ### Response: 1
functional_group
### Instruction: Does the molecule contain a thiol group? Cc1ccsc1/C=C1\Oc2cc(OCC(N)=O)ccc2C1=O ### Response: No
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [11*]S[C@@H]1N=NC(=O)[C@H]2C=C(c3ccc(CC)cc3)NN21 Fragment 2: [1*]C(=O)C[4*] ### Response: CCc1ccc(C2=C[C@@H]3C(=O)N=N[C@@H](SCC(=O)Nc4cccc(C)c4)N3N2)cc1
functional_group
### Instruction: Does the molecule contain a halide group? CCc1ncc(C(=O)N2CCN(c3cccc(OC)c3)CC2)s1 ### Response: No
functional_group
### Instruction: Does the molecule contain a ester group? COc1ccc([C@@H](C)N(C)C(=O)N[C@H]2CC[NH+](CC3CC3)C2)cc1 ### Response: No
ring_counting
### Instruction: Count the five-membered rings in the following molecule. COC(=O)CCN(Cc1ccccc1C#N)C(C)C ### Response: 0
functional_group
### Instruction: Does the molecule contain a ether group? Cc1nc(NC(=O)c2ccncc2C#CCCO)sc1C ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. C1N(CCC[C@@H]1COCC#C)S(=O)(c1cc(F)ccc1F)=O ### Response: C#CCOC[C@H]1CCCN(S(=O)(=O)c2cc(F)ccc2F)C1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [14*]c1ccc([14*])o1 Fragment 2: [4*][C@@H](C)c1ccc([14*])o1 ### Response: C[C@H](SCC[NH3+])c1ccc(C(=O)[O-])o1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N[C@H]([8*])C Fragment 2: [14*]c1nc(C)c([14*])s1 ### Response: COCCCC(=O)N[C@@H](C)c1sc(-c2ccccc2F)nc1C
canonicalization
### Instruction: Canonicalize the following SMILES string. n1(cnc2c(cccc12)Cl)C ### Response: Cn1cnc2c(Cl)cccc21
functional_group
### Instruction: Does the molecule contain a sulfonyl group? COC(=O)c1ccc(C)c(NC(=O)[C@H](C)Oc2cccc(C)c2)c1 ### Response: No
ring_counting
### Instruction: Count the six-membered rings in the following molecule. COC(=O)c1cccc(CCNC(=O)N[C@H]2CCCC[C@H]2C(F)(F)F)c1 ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(ccc(cc1)Cl)C1C[C@H]2c3c(cccc3)O[C@H](N2N=1)c1ccncc1 ### Response: Clc1ccc(C2=NN3[C@@H](C2)c2ccccc2O[C@H]3c2ccncc2)cc1
canonicalization
### Instruction: Canonicalize the following SMILES string. C(/c1ccccc1)=C\CSc1n(c(-c2ccc(c(c2)OC)OC)nn1)N ### Response: COc1ccc(-c2nnc(SC/C=C/c3ccccc3)n2N)cc1OC
canonicalization
### Instruction: Canonicalize the following SMILES string. c1c(c(ccc1C(=O)CCC(=O)Nc1ccc(c(c1)C(=O)N(C)C)F)C)C ### Response: Cc1ccc(C(=O)CCC(=O)Nc2ccc(F)c(C(=O)N(C)C)c2)cc1C
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CS[C@H]1CCCC[NH+](Cc2ccc(OCc3c(C)noc3C)cc2)C1 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1c(onc1CC)CNC(=O)N1CCC(CC1)OCc1ccccc1C ### Response: CCc1cc(CNC(=O)N2CCC(OCc3ccccc3C)CC2)on1
canonicalization
### Instruction: Canonicalize the following SMILES string. N(c1c[nH]nc1-c1ccccn1)C(=O)N1Cc2cc(ccc2CC1)OCC ### Response: CCOc1ccc2c(c1)CN(C(=O)Nc1c[nH]nc1-c1ccccn1)CC2
ring_counting
### Instruction: Count the five-membered rings in the following molecule. C[NH+](CCC(=O)NC(=O)Nc1ccccc1)Cc1ccccc1F ### Response: 0
canonicalization
### Instruction: Canonicalize the following SMILES string. O=C(N/N=C/c1sc(cc1)C)c1ccc(F)cc1 ### Response: Cc1ccc(/C=N/NC(=O)c2ccc(F)cc2)s1
functional_group
### Instruction: Does the molecule contain a ether group? CCOC(=O)CSc1nnc2c3c(C)c(C)sc3ncn12 ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)[C@H]1C[C@@H](O)[C@H](O)[C@@H]2N=C(N[5*])S[C@@H]21 Fragment 2: [5*]NCc1ccccc1 ### Response: CSc1ccc(NC2=N[C@H]3[C@@H](O)[C@H](O)C[C@H](C(=O)NCc4ccccc4)[C@H]3S2)cc1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COc1ccc(C(=O)N2C[C@@H]3C[C@H](C2)c2ccc(-c4ccc5ccccc5c4)c(=O)n2C3)cc1 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)c1cc2occc2n1C Fragment 2: [5*]Nc1cc(Cl)ccc1Cl ### Response: Cn1c(C(=O)Nc2cc(Cl)ccc2Cl)cc2occc21
canonicalization
### Instruction: Canonicalize the following SMILES string. N1(C(c2ccc(Cl)cc2)=O)C[C@H](C(NCC)=O)CC[C@@H]1c1ccccc1 ### Response: CCNC(=O)[C@@H]1CC[C@H](c2ccccc2)N(C(=O)c2ccc(Cl)cc2)C1
canonicalization
### Instruction: Canonicalize the following SMILES string. O=S1(C[C@@H](N(C(C[NH+]([C@@H]2CCC[C@@H](C2)C)C)=O)CCCC)CC1)=O ### Response: CCCCN(C(=O)C[NH+](C)[C@@H]1CCC[C@H](C)C1)[C@H]1CCS(=O)(=O)C1
canonicalization
### Instruction: Canonicalize the following SMILES string. [C@@H]1(CC(=O)N(c2ccc(cc2)Cl)C1)C(N1CC(C1)c1nc(-c2ncccn2)no1)=O ### Response: O=C([C@H]1CC(=O)N(c2ccc(Cl)cc2)C1)N1CC(c2nc(-c3ncccn3)no2)C1
functional_group
### Instruction: Does the molecule contain a ether group? C[NH2+]Cc1ccc(OC)c(C[NH+]2C[C@H](C)[C@@H](C)C2)c1 ### Response: Yes
functional_group
### Instruction: Does the molecule contain a aldehyde group? COc1ccc(F)cc1NC(=O)N[C@H]1CCCn2nc(C(C)C)nc21 ### Response: No
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCCO/N=C(/N)c1cccnc1N1CCCCC1 ### Response: 3
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1c(C(=O)Nc2ccc(F)cc2OCC(F)F)cnn1C ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [13*][C@H]1Cc2ccccc2O1 Fragment 2: [3*]O[C@@H](C)C(=O)NNC([6*])=O ### Response: C[C@H](Oc1ccc(F)cc1)C(=O)NNC(=O)[C@H]1Cc2ccccc2O1
functional_group
### Instruction: Does the molecule contain a phenol group? CC(C)N[C@@]1(C#N)CC[C@H](Oc2ccccc2F)C1 ### Response: No
functional_group
### Instruction: Does the molecule contain a ether group? COc1ccc([C@@H](C)[NH2+][C@@H](C)c2ccc(F)cn2)c(OC)c1 ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COc1cccc([C@@H](O)C[NH+]2CCC(C)(C)C2)c1 ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. O=C(NN)CCn1nc(c([N+](=O)[O-])c1)C ### Response: Cc1nn(CCC(=O)NN)cc1[N+](=O)[O-]
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? [NH3+][C@H](C(=O)[O-])c1cccc(OCc2ccc(F)cc2)c1 ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC[C@]1(c2cccc(Cl)c2)NC(=O)N(CC(=O)c2ccc(Cl)s2)C1=O ### Response: 2