task
stringclasses
5 values
input
stringlengths
89
339
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [10*]N1CCOC1=O Fragment 2: [15*][C@@H]1CCC[C@@H](SC)C1 ### Response: CS[C@@H]1CCC[C@@H](Nc2ccc([N+](=O)[O-])cc2N2CCOC2=O)C1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [3*]Oc1ccc(N[5*])cc1C#N Fragment 2: [5*]Nc1ccc([16*])c(C#N)c1 ### Response: CN1C[C@H](C(=O)Nc2ccc(OCC(F)(F)F)c(C#N)c2)CC1=O
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [8*]Cc1ccccc1Cl Fragment 2: [7*]Cc1cnn(C[8*])c1 ### Response: N#C/C(=C\c1cnn(Cc2ccccc2Cl)c1)C(=O)NC[C@@H]1CCCO1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N/C(N)=[NH+]/CC[8*] Fragment 2: [15*]C1CCCCCC1 ### Response: Cc1cnc(CC/[NH+]=C(\N)NC2CCCCCC2)s1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. C[NH+](C)[C@H](CNC(=O)c1cncc(Br)c1)c1ccco1 ### Response: 1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Cc1cc(C)n(-c2cc(N3CCC[C@@H](C(=O)N4CCCCCC4)C3)ncn2)n1 ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [16*]c1ccsc1 Fragment 2: [1*]C(=O)c1cc(C)[nH]n1 ### Response: Cc1cc(C(=O)NC[C@@H]2Cc3cc(-c4ccsc4)cc(Cl)c3O2)n[nH]1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N1CCN(/N=C/c2cc([N+](=O)[O-])ccc2Cl)CC1 Fragment 2: [4*]Cc1cccc2ccccc12 ### Response: O=[N+]([O-])c1ccc(Cl)c(/C=N/N2CCN(Cc3cccc4ccccc34)CC2)c1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Cc1cc(C(=O)O[C@H](C)c2ccccc2N(C)C)ncn1 ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [16*]c1ccc(C#N)cc1 Fragment 2: [14*]c1nc2ccccc2[nH]1 ### Response: CC(C)[C@H](NC(=O)COc1ccc(C#N)cc1)c1nc2ccccc2[nH]1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCN(C(=O)[C@@H](C)n1nc(-c2ccc(F)cc2)ccc1=O)c1ccccc1 ### Response: 3
canonicalization
### Instruction: Canonicalize the following SMILES string. C1CC[C@@H](C)[C@](O)(c2ccc(cc2F)Cl)C1 ### Response: C[C@@H]1CCCC[C@@]1(O)c1ccc(Cl)cc1F
canonicalization
### Instruction: Canonicalize the following SMILES string. c1nc2n(c(c1)C)nc(C(Nc1ccc(cc1)Nc1ccccc1)=O)n2 ### Response: Cc1ccnc2nc(C(=O)Nc3ccc(Nc4ccccc4)cc3)nn12
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCn1ccc(C(=O)NCCC[NH3+])n1 ### Response: 3
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [3*]OCC Fragment 2: [5*][NH+]1CCC[C@H]([C@@H]([8*])O)C1 ### Response: CCOc1ccc(C[NH+]2CCC[C@H]([C@H](O)c3nccn3C)C2)cc1OC
canonicalization
### Instruction: Canonicalize the following SMILES string. C(N1CCC(NC(=O)[C@@H]([NH+](Cc2c(F)cccc2)C)C)CC1)(OCC)=O ### Response: CCOC(=O)N1CCC(NC(=O)[C@H](C)[NH+](C)Cc2ccccc2F)CC1
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? Cn1nnnc1SCC(=O)N[C@H](c1ccccc1)C(F)(F)F ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. [NH2+]([C@H]1CCCc2c1cccc2)Cc1cc(c(c(F)c1)F)F ### Response: Fc1cc(C[NH2+][C@H]2CCCc3ccccc32)cc(F)c1F
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)C[4*] Fragment 2: [5*]N1CCN([5*])CC1 ### Response: Cc1nc(N2CCN(CC(=O)Nc3ccc(F)cc3)CC2)c2cc[nH]c2n1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C(CNC(=O)c1ccoc1)Nc1cc(C(F)(F)F)c[nH]c1=O ### Response: 2
functional_group
### Instruction: Does the molecule contain a sulfonyl group? C[C@H]1CCCN(S(=O)(=O)NC[C@@H](C)N2CCc3ccccc32)C1 ### Response: Yes
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? C=CCCC[C@@H](C)[NH+](C)Cc1nc2ccccc2o1 ### Response: Yes
functional_group
### Instruction: Does the molecule contain a thiol group? CCc1nnc(NNC(=O)C2CCCCC2)nc1[O-] ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. C1CCCCc2c1ncnc2N[C@@H](CC)c1ccccc1 ### Response: CC[C@H](Nc1ncnc2c1CCCCC2)c1ccccc1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [12*]S(=O)(=O)c1c[nH]c2nccc(Cl)c12 Fragment 2: [5*]N[C@H]1CCCN([5*])C1 ### Response: CC(C)C(=O)N[C@H]1CCCN(S(=O)(=O)c2c[nH]c3nccc(Cl)c23)C1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1c(C[NH2+][C@@H](C)c2ccc(Cl)s2)cnn1C ### Response: 2
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CC[C@@H](CSC)N(C)C(=O)c1ccc(S(=O)(=O)C2CCCC2)cc1 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N1CCc2ccccc2C1 Fragment 2: [1*]C(=O)c1cccc([16*])c1 ### Response: C[C@@H](OC(=O)c1cccc(C(F)(F)F)c1)C(=O)N1CCc2ccccc2C1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Cc1cc(C)cc(CCNC(=O)c2cnc3sc(C)cn3c2=O)c1 ### Response: 1
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? C[NH+]1CCN(C(=O)c2cc(-c3ccc4c(c3)OCO4)nc3ccccc23)CC1 ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]Nc1cccc2c1C(=O)NC2 Fragment 2: [1*]C(=O)c1ncn([9*])n1 ### Response: O=C(Nc1cccc2c1C(=O)NC2)c1ncn(-c2ccccc2)n1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CC1(C)C(=O)NC(=O)CN1Cc1cccc(N)[nH+]1 ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. c1cc(/C=N\N=C2\S[C@@H](CCO)C(N2)=O)ccc1N(C)C ### Response: CN(C)c1ccc(/C=N\N=C2/NC(=O)[C@H](CCO)S2)cc1
functional_group
### Instruction: Does the molecule contain a amide group? CCc1ncc(C(=O)NCCc2ccco2)c(C)n1 ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COc1c(F)cc(C[NH+]2C[C@H]3CC[C@@H]2CN(Cc2ccncc2)C3)cc1F ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N1CCc2ccccc21 Fragment 2: [5*]N(C)C ### Response: CN(C)[C@@H](C[NH2+]CC(=O)N1CCc2ccccc21)c1ccccc1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC(C)c1nn(C)c2sc(C(=O)NNC(=O)Cc3ccsc3)cc12 ### Response: 3
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@H](CNS(=O)(=O)c1cccc(C(N)=O)c1)c1ccsc1 ### Response: 3
canonicalization
### Instruction: Canonicalize the following SMILES string. C(C(=O)NNC([C@@H]1C[C@H]1c1c(cccc1)F)=O)Oc1ccccc1C#N ### Response: N#Cc1ccccc1OCC(=O)NNC(=O)[C@@H]1C[C@H]1c1ccccc1F
functional_group
### Instruction: Does the molecule contain a amine group? O=C(c1ccnc(Cl)c1)N1CCOc2ccc(C[NH+]3CCc4ccccc4C3)cc2C1 ### Response: No
ring_counting
### Instruction: Count the six-membered rings in the following molecule. NC(=O)CONC(=O)CCCc1ccc2[nH]c(=O)[nH]c2c1 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCOC(=O)Nc1scc(-c2ccc(CC)cc2)c1C(=O)OC ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. C1(/C(N=C(N1c1cc2c(cccc2)cc1)C)=C/c1ccc(cc1)OC(C)C)=O ### Response: CC1=N/C(=C\c2ccc(OC(C)C)cc2)C(=O)N1c1ccc2ccccc2c1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Cc1ccc2nc(COc3ccc(C(=O)N4CCC[C@@H](c5nc6ccccc6[nH]5)C4)cc3)cn2c1 ### Response: 4
canonicalization
### Instruction: Canonicalize the following SMILES string. C(=O)(C(NC(CC)CC)=O)Nc1cc(ccc1)NC(CC)=O ### Response: CCC(=O)Nc1cccc(NC(=O)C(=O)NC(CC)CC)c1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCc1ccc(CC)c(NC(=O)NC[C@H]2CCO[C@@H]2C(C)C)c1 ### Response: 3
functional_group
### Instruction: Does the molecule contain a nitro group? COc1ccc([C@H]2C[C@@H](C(F)(F)F)n3nc(C(=O)NCc4cccs4)cc3N2)cc1OC ### Response: No
functional_group
### Instruction: Does the molecule contain a nitro group? CCn1c(CNC(=O)CCn2c(=O)oc3cc(Cl)ccc32)nc2ccccc21 ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. c12cccnc1[C@@H]([C@@H]([NH2+]CC)CSC)CCC2 ### Response: CC[NH2+][C@@H](CSC)[C@H]1CCCc2cccnc21
functional_group
### Instruction: Does the molecule contain a carboxyl group? Cc1cc([N+](=O)[O-])cnc1Nc1cnn(CC(=O)NCCO)c1 ### Response: No
functional_group
### Instruction: Does the molecule contain a ether group? Cc1ccc(Cn2c(=O)n(C[C@@H]3CCCO3)c(=O)c3ccccc32)cc1 ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. O=C(Nc1c(C(=S)N)cn[nH]1)c1ccsc1 ### Response: NC(=S)c1cn[nH]c1NC(=O)c1ccsc1
functional_group
### Instruction: Does the molecule contain a thiol group? Cc1nccn1C(=O)C1CCCCC1 ### Response: No
functional_group
### Instruction: Does the molecule contain a sulfonyl group? COc1ccc(S(=O)(=O)N2CCN(C(=O)c3ccc(F)cc3)CC2)cc1 ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [3*]OCC Fragment 2: [5*]Nc1cccc(N([5*])C)c1 ### Response: CCOC[C@@H]1CCCN(C(=O)Nc2cccc(N(C)C(C)C)c2)C1
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? C#CCSc1nnnn1-c1ccc(C(=O)[O-])cc1 ### Response: Yes
ring_counting
### Instruction: Count the six-membered rings in the following molecule. COc1ccc(N(CC(=O)Nc2c(C)cc(C)cc2C)S(C)(=O)=O)cc1Cl ### Response: 2
functional_group
### Instruction: Does the molecule contain a sulfonyl group? CC[C@H](C)NS(=O)(=O)c1cc(C)c(Cl)cc1C ### Response: Yes
functional_group
### Instruction: Does the molecule contain a amine group? CCN(CCNC(=O)c1ccc(N2CCOC2=O)cc1)c1cccc(C)c1 ### Response: No
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CO[C@@H](C(=O)NCc1ccccc1Oc1ccccc1)c1ccccc1 ### Response: 3
canonicalization
### Instruction: Canonicalize the following SMILES string. c1cc(ccc1Cc1sc(nn1)NC(c1ccc(OC)nn1)=O)C ### Response: COc1ccc(C(=O)Nc2nnc(Cc3ccc(C)cc3)s2)nn1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCCc1nc(SC)ncc1C(=O)N1CCN(c2ccc(Cl)cc2)CC1 ### Response: 3
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CCOc1ccccc1NC(=O)c1cc2c([nH]c1=O)C[C@@H](c1ccccc1)CC2=O ### Response: 0
functional_group
### Instruction: Does the molecule contain a amide group? Cc1csc(S[C@H](C)C(=O)NC[C@H]2CCCO2)n1 ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. C(=N\NC1NNc2n(c3c(n2)cccc3)C=1)/c1ccc(Cl)cc1 ### Response: Clc1ccc(/C=N/NC2=Cn3c(nc4ccccc43)NN2)cc1
canonicalization
### Instruction: Canonicalize the following SMILES string. Clc1ccc(C(=O)N2CSC[C@H]2C(Nc2cc3cccnc3cc2)=O)cc1 ### Response: O=C(Nc1ccc2ncccc2c1)[C@@H]1CSCN1C(=O)c1ccc(Cl)cc1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N1CCCC1 Fragment 2: [1*]C(=O)c1ccc(S(N)(=O)=O)cc1 ### Response: NS(=O)(=O)c1ccc(C(=O)Nc2ccc(N3CCCC3)nc2)cc1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1ccc(-c2nc3ncnn3c(c2)N2CCC[C@H](O)C2)cc1 ### Response: O[C@H]1CCCN(c2cc(-c3ccccc3)nc3ncnn23)C1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)[C@@H](C)N[5*] Fragment 2: [5*]Nc1nnc([14*])s1 ### Response: CCC(CC)c1nnc(NC(=O)[C@@H](C)NC(N)=O)s1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@H](NC(=O)CSc1nc2scc(-c3cccs3)c2c(=O)n1C)c1ccc(F)cc1 ### Response: 2
functional_group
### Instruction: Does the molecule contain a amide group? O=C(c1csnn1)N1CCCCC[C@@H]1c1ccco1 ### Response: Yes
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CC[C@@H](C)NC(=O)[C@H]1CSCN1C(=O)[C@H]1SCCc2sccc21 ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. O=C(N[C@](C(F)(F)F)(C(=O)[O-])C)/C=C/C=C/C ### Response: C/C=C/C=C/C(=O)N[C@@](C)(C(=O)[O-])C(F)(F)F
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@@H]1CN(C(=O)CCc2ccccc2)C[C@@H](C)O1 ### Response: 3
canonicalization
### Instruction: Canonicalize the following SMILES string. C(CCC(N(C)c1ccc(-c2ccccc2)cc1)=O)S(C)(=O)=O ### Response: CN(C(=O)CCCS(C)(=O)=O)c1ccc(-c2ccccc2)cc1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[NH+]1CCC(CNC(=O)C(=O)Nc2cccc3cnccc23)CC1 ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC(=O)/N=C1\NC(=O)/C(=C\c2ccc(N3CCC(Cc4ccccc4)CC3)c([N+](=O)[O-])c2)S1 ### Response: 2
functional_group
### Instruction: Does the molecule contain a amide group? CC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCN(C(=O)c2cccc(F)c2)CC1 ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*][C@H](C)CN[5*] Fragment 2: [5*][NH+]1CCc2ccccc2C1 ### Response: COc1cc(C)c(C(=O)NC[C@@H](C)[NH+]2CCc3ccccc3C2)cc1OC
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? COc1ccc(CC(=O)N2CCN(Cc3nc(-c4ccc(C)cc4)no3)CC2)c(OC)c1 ### Response: Yes
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CNc1cc(C[C@H](NC(=O)C(C)C)c2cccc(C)c2)nc(C2CC2)n1 ### Response: 0
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]CCn1c(C)csc1=O Fragment 2: [5*][NH+]1CCC([15*])CC1 ### Response: Cc1csc(=O)n1CC[NH+]1CCC(OCc2ccccc2F)CC1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CCC[NH2+][C@@H](Cc1nc2ccccc2s1)c1cnn(C)c1 ### Response: 1
functional_group
### Instruction: Does the molecule contain a ether group? COc1ccc(S(=O)(=O)[N-]c2cc(-c3n[nH]c(=O)[nH]3)cc(C(F)(F)F)c2)cc1Br ### Response: Yes
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Cc1cccc(NC(=O)c2cccn(Cc3ccccc3F)c2=O)c1 ### Response: 3
canonicalization
### Instruction: Canonicalize the following SMILES string. c1cc2c(CC(N(CC)CC)=O)cn(Cc3ccc(cc3)Cl)c2cc1 ### Response: CCN(CC)C(=O)Cc1cn(Cc2ccc(Cl)cc2)c2ccccc12
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=S(=O)(/N=C(\[O-])c1ccsc1)N1CCCC1 ### Response: 1
functional_group
### Instruction: Does the molecule contain a halide group? Cn1ncc(C(=O)[O-])c1C(=O)NCC1CC[NH+](Cc2ccccc2)CC1 ### Response: No
functional_group
### Instruction: Does the molecule contain a sulfonyl group? Cc1[nH]nc2cc([N-]S(=O)(=O)c3ccc4ccccc4c3)ccc12 ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCCN1C(=O)N[C@@](C)(c2ccc3c(c2)OCO3)C1=O ### Response: 3
ring_counting
### Instruction: Count the five-membered rings in the following molecule. O=C(NCC1(O)CCOCC1)c1cc([N+](=O)[O-])ccc1N1CCCCC1 ### Response: 0
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CCN/C([S-])=[NH+]\S(=O)(=O)c1ccc(Cl)cc1 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC(C)=CCC[C@H](C)[NH2+]CC1(O)CCOCC1 ### Response: 7
ring_counting
### Instruction: Count the six-membered rings in the following molecule. COc1ccc(N2C(=O)/C(=C\c3ccc(-c4ccc([N+](=O)[O-])cc4)o3)SC2=S)cc1 ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N1CCO[C@]([13*])(C)C1 Fragment 2: [1*]C(=O)C[4*] ### Response: CCCCS(=O)(=O)NCC(=O)N1CCO[C@@](C)(c2ccccc2)C1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C=CCN(CCc1ccccc1)c1c(C#N)c(=O)n(C)c(=O)n1C ### Response: 3
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [6*]C(N)=O Fragment 2: [4*][C@@H](C)CCCC=C ### Response: C=CCCC[C@H](C)[NH+]1CCN(c2ccc(C(N)=O)cc2)CC1
functional_group
### Instruction: Does the molecule contain a nitrile group? N#C[C@H]1CN(C(=O)C2(c3ccc(F)cc3F)CCCC2)CCO1 ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. c1c(ccc(NC(N2[C@@H](CCC2)c2nc(no2)C2CC2)=O)c1)C(C)(C)C ### Response: CC(C)(C)c1ccc(NC(=O)N2CCC[C@H]2c2nc(C3CC3)no2)cc1
canonicalization
### Instruction: Canonicalize the following SMILES string. N(N)c1c([N+]([O-])=O)c(ncn1)Nc1ccccc1 ### Response: NNc1ncnc(Nc2ccccc2)c1[N+](=O)[O-]