task
stringclasses
5 values
input
stringlengths
89
339
canonicalization
### Instruction: Canonicalize the following SMILES string. O=S(C)(c1ccc([C@@H](N(c2ccc3ccc(F)cc3n2)C)C)cc1)=O ### Response: C[C@@H](c1ccc(S(C)(=O)=O)cc1)N(C)c1ccc2ccc(F)cc2n1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [11*]Sc1cc(N)ccc1C Fragment 2: [15*][C@H]1CCOC2(CCC2)C1 ### Response: Cc1ccc(N)cc1S[C@H]1CCOC2(CCC2)C1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC(C)(C)c1noc(CCC(=O)N(CC2CC2)c2ccccc2)n1 ### Response: 3
ring_counting
### Instruction: Count the six-membered rings in the following molecule. O=C(N/N=C/c1cc(Br)ccc1O)[C@@H]1C=C(c2ccccc2)N=N1 ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. Clc1ccc(cc1C(Nc1ccc(C)cc1)=O)SC ### Response: CSc1ccc(Cl)c(C(=O)Nc2ccc(C)cc2)c1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(cc(c(cc1)Cl)C)OC(=O)Cn1ncc2ccccc2c1=O ### Response: Cc1cc(OC(=O)Cn2ncc3ccccc3c2=O)ccc1Cl
canonicalization
### Instruction: Canonicalize the following SMILES string. c1nc(sc1-n1cncc1)N ### Response: Nc1ncc(-n2ccnc2)s1
functional_group
### Instruction: Does the molecule contain a amide group? CSc1ccccc1NC(=O)[C@H]1CCCN(c2cc(-n3nc(C)cc3C)ncn2)C1 ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [15*]C1CC1 Fragment 2: [4*]Cc1cc(OC)cc(OC)c1 ### Response: COc1cc(C[NH+]2CCC[C@]3(CCC(=O)N(C4CC4)C3)C2)cc(OC)c1
canonicalization
### Instruction: Canonicalize the following SMILES string. C(Cc1ccc(F)cc1)(=O)NC1CCN(CC1)c1nc(c(-c2ccncc2)cn1)C(C)C ### Response: CC(C)c1nc(N2CCC(NC(=O)Cc3ccc(F)cc3)CC2)ncc1-c1ccncc1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCN(CC)c1ccc(N2C(=O)/C(=C\C3=c4ccccc4=[NH+]C3)SC2=S)cc1 ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]Nc1ccccn1 Fragment 2: [16*]c1cc(F)cc(OC)c1 ### Response: COc1cc(F)cc(NC(=O)Nc2ccccn2)c1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. O=C(N[C@@H]1CC[NH+]2CCCC[C@H]12)[C@@H]1C[C@H]1c1ccc(C(F)(F)F)cc1 ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [11*]Sc1ccc(C)cc1 Fragment 2: [15*][C@@H]1CCCCNC1=O ### Response: Cc1ccc(S[C@@H]2CCCCNC2=O)cc1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. O=C(CN1C(=O)CCC1=O)N1CCN(Cc2cc(Cl)cc(Cl)c2)CC1 ### Response: 1
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? Cc1cccc(SC[C@@H]2CSc3ccccc32)c1N ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C(Nc1ccccc1O)C1CC[NH+](Cc2cccc(F)c2Cl)CC1 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*][NH+]1CCc2c(N)cccc2C1 Fragment 2: [15*][C@@H]1CCC[C@@H](S(C)(=O)=O)C1 ### Response: CS(=O)(=O)[C@@H]1CCC[C@@H]([NH+]2CCc3c(N)cccc3C2)C1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [14*]c1ccc(C)c[nH+]1 Fragment 2: [9*]n1cc([16*])cn1 ### Response: Cc1ccc(N2CCC(NC(=O)Nc3cnn(CC(F)F)c3)CC2)[nH+]c1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CCCn1c(SCC(=O)N(C)[C@@H](C)c2nc3ccccc3s2)nc2sc3c(c2c1=O)CCC3 ### Response: 3
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CCOC[C@H]1CC[NH+]([C@@H](C)c2nnc(-c3ccc(C)cc3)o2)C1 ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [14*]c1n[nH]c(=O)c2ccccc12 Fragment 2: [5*]N1C[C@H](C)O[C@@H](C)C1 ### Response: C[C@H]1CN(CCNC(=O)Cc2n[nH]c(=O)c3ccccc23)C[C@H](C)O1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(N2C(=O)C[C@H](C2=O)SC[C@@H](NC(C)=O)C([O-])=O)cc(ccc1)OC ### Response: COc1cccc(N2C(=O)C[C@@H](SC[C@@H](NC(C)=O)C(=O)[O-])C2=O)c1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N1C[C@H](C)OC[C@@H]1C Fragment 2: [1*]C(=O)CS[11*] ### Response: C[C@H]1CN(C(=O)CSCc2ccc(Cl)cc2)[C@@H](C)CO1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Cn1cnc2cc(OS(=O)(=O)/C=C/c3ccccc3)ccc21 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCn1nc(C)cc1-c1nnc(CCC(=O)N2CCN(Cc3ccc(F)cc3)CC2)o1 ### Response: 3
functional_group
### Instruction: Does the molecule contain a amide group? O=C(CC1CCN(C(=O)N[C@H]2CCC[C@@H](C3CC3)C2)CC1)N1CCCC1 ### Response: Yes
functional_group
### Instruction: Does the molecule contain a hydroxyl group? CCc1nsc(NCC(=O)NC(C)(C)C)n1 ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. c1c(N)ccc(c1)OCC(Nc1cccc2c1cccc2)=O ### Response: Nc1ccc(OCC(=O)Nc2cccc3ccccc23)cc1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. C[C@H]1C[C@H]1C(=O)NC1CCN(S(=O)(=O)C2CC2)CC1 ### Response: 0
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [3*]OCC[4*] Fragment 2: [4*]CC1CC1 ### Response: CN(CCOCC1CC1)c1ccc2nnc(C(F)(F)F)n2n1
functional_group
### Instruction: Does the molecule contain a ether group? O=S(=O)(NCc1ccc2c(c1)OCCO2)C1CCOCC1 ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [6*]C(=O)N/N=C1\C(=O)Nc2c(C)ccc(Cl)c21 Fragment 2: [16*]c1ccc(Cl)cc1 ### Response: Cc1ccc(Cl)c2c1NC(=O)/C2=N\NC(=O)c1ccc(Cl)cc1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Cc1cc(S(=O)(=O)NCCOc2ccc3nnc(-c4ccccc4)n3n2)ccc1F ### Response: 1
functional_group
### Instruction: Does the molecule contain a ether group? Cc1nn(Cc2ccc(F)cc2)c(Cl)c1/C=C(\C#N)C(=O)Nc1ccc2c(c1)OCCO2 ### Response: Yes
functional_group
### Instruction: Does the molecule contain a hydroxyl group? CC[C@H](C)CN(CC)C(=O)[C@@H](/C(N)=N/O)c1ccccc1 ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C(Cn1ccc2ccccc21)N[C@@H]1CCS(=O)(=O)C1 ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. CCOc1c(ccc(c1)/C=N/c1c(n[nH]c1C)C)OCCC ### Response: CCCOc1ccc(/C=N/c2c(C)n[nH]c2C)cc1OCC
functional_group
### Instruction: Does the molecule contain a ester group? CC[C@@H](C)NC(=O)CN1CCN(C(=O)Nc2ccccc2Oc2ccccc2Cl)CC1 ### Response: No
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*][C@@H](N[5*])C(Cl)(Cl)Cl Fragment 2: [16*]c1ccccc1 ### Response: O=C(N[C@H](NC(=S)Nc1ccccc1)C(Cl)(Cl)Cl)c1cccc(Br)c1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COc1ccc(CNC(=O)Cn2cnc3scc(-c4ccc(C)s4)c3c2=O)cc1OC ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [16*]c1ccc(Br)c(Cl)c1 Fragment 2: [1*]C(=O)c1cc(OC)c(OC)c(OC)c1 ### Response: COc1cc(C(=O)NC(=S)Nc2ccc(Br)c(Cl)c2)cc(OC)c1OC
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? CC(=O)Nc1cc(NC(=O)NC[C@](C)(O)CCC(C)C)ccc1C ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C1C[C@@H](c2ccc(Cl)cc2)CC2=C1[C@@H](c1ccccn1)Nc1ccccc1N2 ### Response: 0
canonicalization
### Instruction: Canonicalize the following SMILES string. CC1(C)c2cc(S(=O)(N3CCC[C@@H]3CC(=O)c3cn(C)nc3)=O)ccc2NC1=O ### Response: Cn1cc(C(=O)C[C@H]2CCCN2S(=O)(=O)c2ccc3c(c2)C(C)(C)C(=O)N3)cn1
canonicalization
### Instruction: Canonicalize the following SMILES string. Fc1c(c(F)cc(C(=O)N(C2CC2)Cc2ccccc2OC)c1F)F ### Response: COc1ccccc1CN(C(=O)c1cc(F)c(F)c(F)c1F)C1CC1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CC[C@H]1CCCN(C(=O)c2cc(C)n(-c3nccs3)c2C)C1 ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. C1CC[C@H](O1)CC(=O)NCCCO ### Response: O=C(C[C@@H]1CCCO1)NCCCO
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)C1([15*])CCOCC1 Fragment 2: [5*]N[C@@H]1CCC[C@H](SC)C1 ### Response: CS[C@H]1CCC[C@@H](NC(=O)C2(c3ccccc3)CCOCC2)C1
functional_group
### Instruction: Does the molecule contain a halide group? CCOC(=O)CC[C@@H]1CCC[NH+](Cc2n[nH]c(=O)[nH]2)C1 ### Response: No
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=S(=O)(NC[C@@H](c1ccccc1)[NH+]1CCCC1)c1ccc(F)cc1 ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCN(c1ccc(-c2csc(NC[C@H]3CCCO3)n2)cc1)S(C)(=O)=O ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N[C@H](C)C[C@@H](C)CC Fragment 2: [1*]C(=O)c1cc([14*])no1 ### Response: CC[C@H](C)C[C@@H](C)NC(=O)c1cc(C(C)C)no1
functional_group
### Instruction: Does the molecule contain a aldehyde group? C[C@H](CCCO)Nc1[nH+]c2ccccc2n1C ### Response: No
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@@H](NC(=O)[C@@H]1SCCc2sccc21)C(=O)NCc1ccccc1 ### Response: 3
functional_group
### Instruction: Does the molecule contain a nitro group? O=C(Nc1nc2ccccc2s1)[C@H]1CC(=O)N(c2ccc(F)c(Cl)c2)C1 ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. n1c(C[NH2+][C@H]2[C@@H](CN(C(C(C)C)=O)CC2)C)cccc1 ### Response: CC(C)C(=O)N1CC[C@@H]([NH2+]Cc2ccccn2)[C@H](C)C1
functional_group
### Instruction: Does the molecule contain a ether group? COc1cc([C@H]2C(C(=O)Nc3ccccn3)=C(C)NC3=C2C(=O)CCC3)ccc1OCc1ccccc1 ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)c1cnc2c(c1)c(=O)[nH]c(=O)n2C Fragment 2: [6*]C(N)=O ### Response: Cn1c(=O)[nH]c(=O)c2cc(C(=O)N3CC[C@@H](C(N)=O)C3)cnc21
functional_group
### Instruction: Does the molecule contain a ketone group? Cc1ccc(-c2cccc(CN3CCC[C@H](c4nnc5n4CCC5)C3)c2)cc1 ### Response: No
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? NC(=O)[C@@H]1CCCC[NH+]1CC(=O)NC(=O)NCC(F)(F)F ### Response: 2
functional_group
### Instruction: Does the molecule contain a ether group? CC(=O)N1CCCCC[C@H]1C1CC[NH+](CCS(=O)(=O)c2ccccc2)CC1 ### Response: No
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COCCN1CCN(C(=O)c2cc3cc(F)ccc3[nH]2)CC1=O ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COc1ncccc1CNC(=O)[C@H]1CC(=O)N(c2ccc3c(c2)OCO3)C1 ### Response: 1
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? CC[C@H](C)[NH2+]Cc1ccc(N(C)C)cc1 ### Response: Yes
functional_group
### Instruction: Does the molecule contain a halide group? CCN(C(=O)c1cccnc1)[C@H]1CC[NH+]([C@@H](C)c2ccccc2)C1 ### Response: No
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? COC(=O)c1ccc(C(=O)Nc2nc3ccc(NC(C)=O)cc3s2)cc1 ### Response: Yes
functional_group
### Instruction: Does the molecule contain a amide group? CC(C)(C)c1cc(NC(=O)C2CN(C(=O)c3ccc([N+](=O)[O-])o3)C2)on1 ### Response: Yes
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CC(=O)[C@@](C)(Cl)Cc1ccc(Cl)cc1 ### Response: 0
canonicalization
### Instruction: Canonicalize the following SMILES string. c1cc(NC(C(=O)NCCc2c[nH]c3ccc(Cl)cc23)=O)c(CC)cc1 ### Response: CCc1ccccc1NC(=O)C(=O)NCCc1c[nH]c2ccc(Cl)cc12
functional_group
### Instruction: Does the molecule contain a amide group? C[C@@H](NC(=O)NCC(=O)N1CCc2ccccc21)c1ccc(Cl)cc1Cl ### Response: Yes
ring_counting
### Instruction: Count the six-membered rings in the following molecule. O=C(Nc1ccc(C(=O)OC[C@@H]2CCC[NH+]3CCCC[C@@H]23)cc1)c1ccc([N+](=O)[O-])cc1 ### Response: 4
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [14*]c1cccs1 Fragment 2: [1*]C(=O)c1ccc(CC)cc1 ### Response: CCc1ccc(C(=O)N2CCOC[C@H]2C[C@H](O)c2cccs2)cc1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [12*]S(=O)(=O)c1cc2c(cc1C)NC(=O)[C@@H](CC)O2 Fragment 2: [5*]Nc1cccnc1 ### Response: CC[C@H]1Oc2cc(S(=O)(=O)N3CCC[C@H](C(=O)Nc4cccnc4)C3)c(C)cc2NC1=O
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [3*]Oc1ncccc1C#N Fragment 2: [8*]C(C)(C)C ### Response: CC(C)(C)c1ccc(Oc2ncccc2C#N)cc1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CN(C)S(=O)(=O)N1CC[NH+](CCc2ccccc2C(F)(F)F)CC1 ### Response: 2
ring_counting
### Instruction: Count the five-membered rings in the following molecule. C[NH2+]C[C@H](C)C(=O)NCCCc1ccccc1 ### Response: 0
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CN1CCCN(S(=O)(=O)c2ccccc2F)c2cc(F)ccc21 ### Response: 2
ring_counting
### Instruction: Count the five-membered rings in the following molecule. O=C(NNc1cccc(C(F)(F)F)c1)c1cccc2cccnc12 ### Response: 0
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1ccc2oc3c(c(=O)c2c1)[C@H](c1ccc([N+](=O)[O-])cc1)N(c1cc(C)on1)C3=O ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1c[nH]c(=O)n1-c1ccc([C@H](C)[NH2+]C[C@H]2C[NH+]3CCN2CC3)cc1 ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C(Cn1cc(C2CC2)nn1)NC1c2ccccc2Oc2ccccc21 ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [8*][C@@H](Cl)C#N Fragment 2: [8*]CC(C)C ### Response: CC(C)Cc1ccc([C@@H](Cl)C#N)cc1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CC[NH+](CC)[C@H](C)CNC(=O)N1CCC[C@H](NC(C)=O)C1 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. C1CCC[C@H]2[NH+]1CC[C@@H]2NC(=O)C(Nc1c(cccc1F)F)=O ### Response: O=C(Nc1c(F)cccc1F)C(=O)N[C@H]1CC[NH+]2CCCC[C@H]12
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? N#CCOc1ccc(CC(=O)N2CC=C(c3ccccc3Cl)CC2)cc1 ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CN(CC1CC[NH+](C)CC1)[C@@H](C[NH3+])c1cc(Cl)cs1 ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. O=C(N1C[C@@H](OC[C@@H]1C)C)c1nc(CC)n(-c2c(Cl)cccc2)n1 ### Response: CCc1nc(C(=O)N2C[C@H](C)OC[C@@H]2C)nn1-c1ccccc1Cl
functional_group
### Instruction: Does the molecule contain a amine group? Cc1cccc(NC(=O)CSCC(=O)N2CCOC[C@H]2C2CC2)c1 ### Response: No
ring_counting
### Instruction: Count the five-membered rings in the following molecule. O[C@H]1CCN(c2ccnc(N3CCc4[nH]c5ccc(Cl)cc5c4C3)n2)C1 ### Response: 2
functional_group
### Instruction: Does the molecule contain a ester group? COC(=O)[C@@H]1C[C@H]1C(=O)NNc1cc(C#N)cc(Cl)n1 ### Response: Yes
functional_group
### Instruction: Does the molecule contain a ether group? COc1ccc(-n2c(C)cc(C(=O)CSc3ccc(Cl)cc3)c2C)cc1 ### Response: Yes
ring_counting
### Instruction: Count the five-membered rings in the following molecule. O=C(/C=C/Nc1ccc(F)c(Cl)c1)c1ccc2c(c1)OCO2 ### Response: 1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CC[C@@H]([NH2+]C)[C@@H]1CCO[C@H](C)C1 ### Response: 1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Cc1nc(C[C@@H](C[NH3+])c2ccc(Cl)cc2)sc1C ### Response: 1
functional_group
### Instruction: Does the molecule contain a ketone group? C[C@@H]1CN(c2cc3c(cc2Cl)[C@H](O)C(=O)N3)C[C@H](C)O1 ### Response: No
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? CC(C)C(=O)Nc1cccc(NC(=O)[C@H](C)Oc2ccc(Cl)cc2)c1 ### Response: Yes
functional_group
### Instruction: Does the molecule contain a amide group? CC1CC[NH+](Cc2csc(NC(=O)CSCc3ccco3)n2)CC1 ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. C(N1C(c2c(cccc2)C1=O)=O)CSc1cccc[n+]1[O-] ### Response: O=C1c2ccccc2C(=O)N1CCSc1cccc[n+]1[O-]
functional_group
### Instruction: Does the molecule contain a amide group? COc1ccccc1NC(=O)NCc1ccnc(OCc2ccccc2)c1 ### Response: Yes