task
stringclasses
5 values
input
stringlengths
89
339
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1n[nH]c(-c2cccc(CNC(=O)Cc3cccc(OC(C)C)c3)c2)n1 ### Response: 3
canonicalization
### Instruction: Canonicalize the following SMILES string. c12c(cccc2)ccc(N2[C@]3(S[C@H](C)C2=O)C(N(C(=O)C)c2ccccc32)=O)c1 ### Response: CC(=O)N1C(=O)[C@]2(S[C@H](C)C(=O)N2c2ccc3ccccc3c2)c2ccccc21
ring_counting
### Instruction: Count the six-membered rings in the following molecule. C[C@H](C(=O)NCC(F)(F)F)[S@](=O)Cc1c(F)cccc1Cl ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [8*]C(C)(C)C Fragment 2: [12*]S(=O)(=O)c1ccc([16*])cc1 ### Response: CC(C)(C)c1ccc(S(=O)(=O)Nc2cccc(-c3c[nH+]c4n3CCC4)c2)cc1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. COCCn1c(-c2ccccc2C)nc2c(c(=O)c3ccccc3n2C)c1=O ### Response: 0
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)C[4*] Fragment 2: [11*]S[C@H]1CCS(=O)(=O)C1 ### Response: O=C([O-])[C@H]1C[C@H](O)CN1C(=O)CS[C@H]1CCS(=O)(=O)C1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. COC(=O)c1ccc(OP(=O)(c2ccccc2)c2ccccc2)cc1 ### Response: 0
canonicalization
### Instruction: Canonicalize the following SMILES string. C(C)[C@H](C)CN(C(=O)N[C@H](c1cc(c(cc1)C)F)C)C ### Response: CC[C@H](C)CN(C)C(=O)N[C@@H](C)c1ccc(C)c(F)c1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [3*]OC(F)(F)F Fragment 2: [1*]C(=O)CCl ### Response: O=C(CCl)Nc1ccc(Cl)cc1/C(=N/O)c1ccccc1OC(F)(F)F
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N(C)CC Fragment 2: [1*]C(=O)c1cccc(C([1*])=O)c1 ### Response: CCN(C)C(=O)c1cccc(C(=O)N2CC3(CCCC3)c3cc4c(cc3[C@H]2C)OCCO4)c1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@@H]1CN(S(=O)(=O)c2ccc(C(=O)NCCc3ccc(F)cc3)cc2)C[C@@H](C)O1 ### Response: 2
functional_group
### Instruction: Does the molecule contain a amide group? CS(=O)(=O)c1ccc([C@@H]2CC(O)=Nc3c2c(=O)[nH]n3C2CCCCCCC2)cc1 ### Response: No
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C(CSc1ccccn1)Nc1ccccc1C(=O)Nc1ccc(Cl)cc1 ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCCNC(=O)[C@@H]1CCCN(C(=O)c2c[nH]c3cccc(F)c23)C1 ### Response: 3
canonicalization
### Instruction: Canonicalize the following SMILES string. [C@@H]1(CCCC[C@H]1NC(=O)Nc1c(ccnc1)C)SCC ### Response: CCS[C@H]1CCCC[C@H]1NC(=O)Nc1cnccc1C
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CN1Cc2c(O)c(-c3cccnc3)cc3c2c(c(CN2CCOCC2)n3C)C1=O ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. n1nc(NN)sc1SCC(=O)OC ### Response: COC(=O)CSc1nnc(NN)s1
canonicalization
### Instruction: Canonicalize the following SMILES string. C1N(c2c(CC1)cc(cc2)CNC(=O)NCc1c(ocn1)C)C ### Response: Cc1ocnc1CNC(=O)NCc1ccc2c(c1)CCCN2C
functional_group
### Instruction: Does the molecule contain a amine group? CN(CCOCC1CC1)C(=O)[C@](C)(N)C(F)(F)F ### Response: Yes
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CCc1cc(CN2CC[C@@H]([NH3+])[C@H](C)C2)n(CC)n1 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N[C@@H]1C=C(C)ON1 Fragment 2: [1*]C(=O)CCC[8*] ### Response: CC1=C[C@@H](NC(=O)CCCn2c(=O)[nH]c3ccccc3c2=O)NO1
functional_group
### Instruction: Does the molecule contain a amide group? COc1ccc(C)cc1Nc1ncnc(Nc2cccnc2Cl)c1[N+](=O)[O-] ### Response: No
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]Cc1nc([14*])no1 Fragment 2: [16*]c1ccc([16*])cc1 ### Response: CC(C)c1ccc(-c2noc(CNc3ccccc3C(=O)N3CCC[C@H](O)C3)n2)cc1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Cc1cc(O)c(C(=O)c2ccccc2)cc1Cl ### Response: 0
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1cc(I)ccc1[C@H]([NH3+])C(=O)[O-] ### Response: 2
functional_group
### Instruction: Does the molecule contain a thiol group? CC[C@@H](C)[NH+]1CCN(c2ccc(C(C)=O)c(O)c2)CC1 ### Response: No
functional_group
### Instruction: Does the molecule contain a nitro group? C[C@@H]1Cc2ccc(-c3cc(CNC(=O)CSc4ncccn4)no3)cc2O1 ### Response: No
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [6*]C(=O)/N=c1\sc2cc(S(N)(=O)=O)ccc2n1[9*] Fragment 2: [8*]CCC ### Response: CCCn1/c(=N/C(=O)c2cccc(N3C(=O)CCC3=O)c2)sc2cc(S(N)(=O)=O)ccc21
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]Nc1cccc(OC)c1 Fragment 2: [13*][C@H]1S/C(=N\S(=O)(=O)c2ccc(Cl)s2)N(CC)C1=O ### Response: CCN1C(=O)[C@@H](CC(=O)Nc2cccc(OC)c2)S/C1=N\S(=O)(=O)c1ccc(Cl)s1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? N#Cc1cccnc1N1CCC2(CC1)c1nc[nH]c1CCN2C(=O)C1CCC1 ### Response: 1
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? CC(=O)c1ccc(OC[C@H](O)C[NH+]2CC(C)(C)C2(C)C)cc1 ### Response: Yes
functional_group
### Instruction: Does the molecule contain a halide group? CC(=O)Nc1cccc(F)c1 ### Response: Yes
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CC(C)Cn1ncc(C(=O)O[C@@H](C)C2CC2)c1C1CC1 ### Response: 1
functional_group
### Instruction: Does the molecule contain a amide group? CC(C)C(=O)N1CCc2c(c(C(=O)N3CCC(C(=O)NC4CCCCCC4)CC3)nn2C)C1 ### Response: Yes
functional_group
### Instruction: Does the molecule contain a amine group? NNc1nc(NCc2ccco2)c2nc[nH]c2n1 ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@H](C[C@@](C)(O)C[NH3+])N(C)C[C@@H]1CCC[NH+]1C ### Response: 5
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [16*]c1ccc(C[NH3+])cc1 Fragment 2: [13*][C@]1(C)NC(=O)NC1=O ### Response: C[C@@]1(c2ccc(C[NH3+])cc2)NC(=O)NC1=O
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]CC[C@H]1CCC[NH2+]C1 Fragment 2: [4*]CCC ### Response: CCCOc1ccc(OCC[C@H]2CCC[NH2+]C2)cc1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [16*]c1cccc(C)c1 Fragment 2: [9*]n1nc2c([16*])c[n+](CCCO)cc2c1O ### Response: COC(=O)c1c[n+](CCCO)cc2c(O)n(-c3cccc(C)c3)nc12
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N1CC(C)(C)[NH2+]C[C@@H]1CC Fragment 2: [4*]CCc1ccccc1C ### Response: CC[C@H]1C[NH2+]C(C)(C)CN1CCc1ccccc1C
functional_group
### Instruction: Does the molecule contain a thiol group? CCOc1ccc(NC(=O)C(=O)NC[C@]2(O)CCCc3ccccc32)cc1 ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. c1ccc2c([nH]nc(C3=C(c4ccc(C(C)(C)C)cc4)[C@H](C)OC3=O)c2c1)=O ### Response: C[C@@H]1OC(=O)C(c2n[nH]c(=O)c3ccccc23)=C1c1ccc(C(C)(C)C)cc1
canonicalization
### Instruction: Canonicalize the following SMILES string. C(c1oc(C(=O)OC)cc1)Nc1ccc(C)c(c1)OCC ### Response: CCOc1cc(NCc2ccc(C(=O)OC)o2)ccc1C
ring_counting
### Instruction: Count the six-membered rings in the following molecule. O=C([O-])[C@@H]1C=C[C@H](Nc2cc(F)c(Cl)cc2[N+](=O)[O-])C1 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. Cc1c(ccc(F)c1)NC(C(N1CCC(CC1)C(=O)N(CC)CC)=O)=O ### Response: CCN(CC)C(=O)C1CCN(C(=O)C(=O)Nc2ccc(F)cc2C)CC1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C(CSCc1ccccc1)NC(c1ccccc1)c1ccccc1 ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1c2c(cc3c1O/C(=C\c1cccc(Br)c1)C3=O)CN(Cc1ccncc1)CO2 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(NC(CC[NH+]2CCC(CC2)C(NCCC)=O)=O)ccc(Cl)cc1 ### Response: CCCNC(=O)C1CC[NH+](CCC(=O)Nc2ccc(Cl)cc2)CC1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cn1cc2c(n1)c(=O)n(Cc1ccc(F)cc1)c1nn(Cc3c(F)cccc3Cl)c(=O)n21 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cn1c(-c2ccccn2)nn(CCNC(=O)c2cccc(Cl)c2)c1=O ### Response: 2
functional_group
### Instruction: Does the molecule contain a amine group? CC(C)CCNC(=O)[C@H](C)[NH2+][C@H]1CCC[C@@H](C)C1 ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. c1cc(C)c(cc1C)OCCSC[C@H](O)CO ### Response: Cc1ccc(C)c(OCCSC[C@H](O)CO)c1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [16*]c1ccc(SC)cc1 Fragment 2: [15*]C1CC[NH2+]CC1 ### Response: CSc1ccc(C2CC[NH2+]CC2)cc1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Cc1nc(C)c(C#N)c(SCN2C(=O)c3ccccc3C2=O)n1 ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1cccc(NC(=O)CSc2nnc(-c3c[nH]c4ccccc34)o2)c1C ### Response: 2
functional_group
### Instruction: Does the molecule contain a thiol group? O=C(Cn1cnc(-c2cccc([N+](=O)[O-])c2)n1)N1N=C(c2cccs2)C[C@H]1c1cccs1 ### Response: No
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)[C@H](CCC)/C(N)=N/O Fragment 2: [5*]Nc1ccc(C)nc1C ### Response: CCC[C@@H](C(=O)Nc1ccc(C)nc1C)/C(N)=N/O
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(/N=C(\[S-])Nc2cccc(C)c2)cc(Cl)ccc1OC ### Response: COc1ccc(Cl)cc1/N=C(\[S-])Nc1cccc(C)c1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CCc1nc2ccccc2n1C1CCN(c2ccnc(Cl)c2)CC1 ### Response: 1
functional_group
### Instruction: Does the molecule contain a phenol group? CN1CC[NH+](C)CC12CCN(C(=O)c1cccc(CCC(C)(C)O)c1)CC2 ### Response: No
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CCn1ncc(C[NH+](Cc2ccc(F)cc2)C[C@H]2CCCO2)c1C ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [3*]OCC Fragment 2: [5*]N1CCSCC1 ### Response: CCOc1cccc(NC(=O)NCc2ccc(N3CCSCC3)cc2)c1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CNC(=O)C1CCN(c2ccc([N+](=O)[O-])cc2COC)CC1 ### Response: 0
functional_group
### Instruction: Does the molecule contain a thiol group? Cc1ccc(O[C@@H](C)C(=O)NNC(=O)COc2ccccc2Cl)cc1C ### Response: No
functional_group
### Instruction: Does the molecule contain a ether group? O=C1C[NH+](C2CCCC2)C[C@H](OCc2ccccn2)CN1C1CCCCC1 ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [8*]CCCl Fragment 2: [9*]n1c([14*])nc2c(C)nn(C)c21 ### Response: Cc1nn(C)c2c1nc(CCCl)n2[C@@H](C)[C@@H]1CCCO1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Cc1n[nH]c(C2CCN(c3nnc(C4CCC4)o3)CC2)n1 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1c(Cl)cc(cc1)CN1CCN(C(Cn2ccccc2=O)=O)CC1 ### Response: O=C(Cn1ccccc1=O)N1CCN(Cc2cccc(Cl)c2)CC1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. O=C([C@H]1CC[C@@H]2CCCC[C@H]2C1)N1CCC(O)(C(F)(F)F)CC1 ### Response: 3
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]CCC Fragment 2: [14*]c1noc([14*])n1 ### Response: CCCN1CCO[C@@H](c2noc([C@H]3C=C[C@@H]([NH3+])C3)n2)C1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1c(F)cc(N)cc1S(=O)(=O)NC[C@H]1CCC(=O)N1 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COc1ccccc1SCC(=O)Nc1nc(C[NH+]2CCC(C)CC2)cs1 ### Response: 2
functional_group
### Instruction: Does the molecule contain a aldehyde group? NC1=NC(=O)N(Cc2ccccc2)[C@@H]1c1ccccc1Br ### Response: No
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C(c1cc(F)cc(F)c1)N1CCC(c2nc3ccccc3[nH]2)CC1 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]Nc1ccc2nc(N[5*])sc2c1 Fragment 2: [1*]C(=O)c1ccc([16*])cc1 ### Response: COC(=O)c1ccc(C(=O)Nc2nc3ccc(NC(C)=O)cc3s2)cc1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. O=C(NNC(=O)c1cccc(NC(=O)c2ccco2)c1)c1ccncc1 ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*][NH+](C)C Fragment 2: [4*][C@@H]([8*])CN[5*] ### Response: CSc1ncccc1C(=O)NC[C@H](c1cccc(F)c1)[NH+](C)C
canonicalization
### Instruction: Canonicalize the following SMILES string. C(n1cc(c(n1)C(=O)Nc1sc(c(c1C(=O)OCC)C)C)Br)C ### Response: CCOC(=O)c1c(NC(=O)c2nn(CC)cc2Br)sc(C)c1C
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CC1CCN(C(=O)Cc2coc3ccc4ccccc4c23)CC1 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [8*]C(C)(C)C(=O)OC Fragment 2: [5*]N1CCC[C@H]([15*])C1 ### Response: COC(=O)C(C)(C)[C@H]1CCCN(C(=O)[C@H]2C[C@@H]2c2ccccc2F)C1
canonicalization
### Instruction: Canonicalize the following SMILES string. CC(C)[NH2+]C/C(C)=C/c1cc(ccc1)Br ### Response: C/C(=C\c1cccc(Br)c1)C[NH2+]C(C)C
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(OC)ccc(-n2ncc(c2C)[C@H](NS(=O)(c2c3c(ccc2)cccn3)=O)C)cc1 ### Response: COc1ccc(-n2ncc([C@@H](C)NS(=O)(=O)c3cccc4cccnc34)c2C)cc1
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? COc1ccccc1/C=C/C(=O)NC(=S)Nc1cccc(Cl)c1C ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC(C)[C@@H](NC(=O)[C@H]1CC(=O)N(C)C1)c1ccccc1 ### Response: 3
functional_group
### Instruction: Does the molecule contain a phenol group? COc1ccc(CNC(=O)NC[C@@H](C)[NH+]2CCc3sccc3C2)cn1 ### Response: No
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC(C)(C)c1ccc(C(=O)N(Cc2cccnc2)c2nc3ccc(S(C)(=O)=O)cc3s2)cc1 ### Response: 3
functional_group
### Instruction: Does the molecule contain a thiol group? NNC(=O)c1ccc([C@H]2C[C@H]2c2ccccc2)cc1 ### Response: No
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [9*]n1ncc([16*])c1C Fragment 2: [4*]CC([8*])(C)C ### Response: Cc1ccc(C)c(-n2ncc(NC(=O)NCC(C)(C)c3ccncc3)c2C)c1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CCCCOc1ccc(C2CC([O-])C2)cc1OC ### Response: 0
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CC1(C)C(=O)Nc2ccccc2N1C(=O)COC(=O)c1cccnc1Cl ### Response: 3
functional_group
### Instruction: Does the molecule contain a phenol group? O=C(CCOc1ccccc1-c1ccccc1)N1CCN(CCO)CC1 ### Response: No
ring_counting
### Instruction: Count the five-membered rings in the following molecule. COCC1(C(=O)N(C)[C@@H](C)c2ccon2)CCC1 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. C(N1CCC(CC1)C(N)=O)(CN(C)c1ccc2nc(sc2c1)C)=O ### Response: Cc1nc2ccc(N(C)CC(=O)N3CCC(C(N)=O)CC3)cc2s1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@@H]1C[C@H]1C(=O)N1CCN(C(=O)NCc2cccc(C#N)c2)CC1 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C(Nc1ccc(Cl)cc1)Nc1ncn[nH]1 ### Response: 1
functional_group
### Instruction: Does the molecule contain a hydroxyl group? O=C(Cc1n[nH]c(=O)c2ccccc12)N1C[C@H]2CCC[C@@](O)(c3ccccc3F)[C@@H]2C1 ### Response: Yes
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? CN(c1ccc(F)cc1)S(=O)(=O)c1c[nH]c2nccc(Cl)c12 ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. c1cc(ccc1OCC)C(N(c1nc2c(F)cccc2s1)Cc1occc1)=O ### Response: CCOc1ccc(C(=O)N(Cc2ccco2)c2nc3c(F)cccc3s2)cc1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCc1cccc(C)c1NC(=O)Cc1cccc(C)c1 ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]NCc1ccc(N[5*])cc1 Fragment 2: [5*]NCc1ccc([16*])cc1 ### Response: COC(=O)NCc1ccc(NC(=O)N[C@@H](C)c2ncc(C)s2)cc1