task
stringclasses
5 values
input
stringlengths
89
339
ring_counting
### Instruction: Count the six-membered rings in the following molecule. [NH3+][C@@H](c1ncc[nH]1)[C@@H]1CCOC2(CCC2)C1 ### Response: 1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. COc1ccc(N(Cc2ccccc2F)S(=O)(=O)c2ccc([N+](=O)[O-])cc2)cc1 ### Response: 3
functional_group
### Instruction: Does the molecule contain a ester group? COC(=O)[C@@H]1c2ccsc2CCN1S(=O)(=O)c1ccc(F)cc1 ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]Cc1cnc(S(C)(=O)=O)n1[9*] Fragment 2: [5*]N1CCOCC1 ### Response: CC(C)Cn1c(C[NH+]2CCC([C@@H](C)N3CCOCC3)CC2)cnc1S(C)(=O)=O
functional_group
### Instruction: Does the molecule contain a sulfonyl group? CCOc1ccc([C@@H](NC(=O)[C@@H]2CCO[C@@H]2C)c2ccccc2)cc1 ### Response: No
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1nn(-c2ccc(F)cc2)c2[nH]c(=O)c(C[NH2+]CCC[NH+]3CCCCCC3)cc12 ### Response: 3
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Cc1nc2ccc(NC(=O)NC3CCN(c4cccc[nH+]4)CC3)cc2o1 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. Fc1c(C(=O)Nc2ccc(C[NH+]3CCCC3)cc2)cc(cc1)F ### Response: O=C(Nc1ccc(C[NH+]2CCCC2)cc1)c1cc(F)ccc1F
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)c1cccc(OC)n1 Fragment 2: [3*]Oc1ccc(C)cc1OC ### Response: COc1cccc(C(=O)Oc2ccc(C)cc2OC)n1
canonicalization
### Instruction: Canonicalize the following SMILES string. c12ccc(C=C)cc1c(c(C#N)c(n2)C(F)(F)F)N ### Response: C=Cc1ccc2nc(C(F)(F)F)c(C#N)c(N)c2c1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C(c1ccc(F)cc1)[C@H]1CCCN(C(=O)CCCn2ccnn2)C1 ### Response: 4
canonicalization
### Instruction: Canonicalize the following SMILES string. C1CCC(CC1)(NC(=O)c1cnn(C(C)C)c1)c1ccc(OC)cc1 ### Response: COc1ccc(C2(NC(=O)c3cnn(C(C)C)c3)CCCCC2)cc1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. C[C@@]1(CO)CCC[NH+](Cc2ccsc2)C1 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. Cc1cccc(c1C)-n1c2c(cn1)c(O)nc(n2)SCC(=O)N ### Response: Cc1cccc(-n2ncc3c(O)nc(SCC(N)=O)nc32)c1C
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCCc1cc(NC(=O)C(=O)N2CCN(c3cccc(C)c3)CC2)n(C)n1 ### Response: 3
canonicalization
### Instruction: Canonicalize the following SMILES string. C1CCCC1C[NH+]1CC[C@H](NC(=O)[C@H]2CN(C(=O)C2)C(C)C)C1 ### Response: CC(C)N1C[C@H](C(=O)N[C@H]2CC[NH+](CC3CCCC3)C2)CC1=O
canonicalization
### Instruction: Canonicalize the following SMILES string. CC1([C@@H](C(=O)C(O1)(C)C)C[NH+]1CC[C@H](CCC1)CC)C ### Response: CC[C@H]1CCC[NH+](C[C@@H]2C(=O)C(C)(C)OC2(C)C)CC1
canonicalization
### Instruction: Canonicalize the following SMILES string. C1CN(C(=O)c2cccc(S(=O)(=O)C)c2)[C@@H](C1)c1n2CCCCCc2nn1 ### Response: CS(=O)(=O)c1cccc(C(=O)N2CCC[C@H]2c2nnc3n2CCCCC3)c1
canonicalization
### Instruction: Canonicalize the following SMILES string. c12c(c(C)cc(c2)C)[C@@H]([NH2+][C@H](c2cn(C)nc2)CO)CCO1 ### Response: Cc1cc(C)c2c(c1)OCC[C@@H]2[NH2+][C@@H](CO)c1cnn(C)c1
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? Cn1c(=O)n(C)c2cc(C(=O)N3CCC[C@@H](n4nc(-c5ccco5)ccc4=O)C3)ccc21 ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [15*]C1CCOCC1 Fragment 2: [5*]N(C)C1CC[NH+]([5*])CC1 ### Response: C[C@@H]1CCC[C@@H](C(=O)N(C)C2CC[NH+](C3CCOCC3)CC2)C1
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? Cc1ccc(C(=O)[C@@H](C#N)c2nc(C(C)C)cs2)cc1C ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC(=O)N1CCN(Cc2nc3sc4c(c3c(=O)[nH]2)CC[C@H](C(C)(C)C)C4)CC1 ### Response: 3
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CC[C@H]1NC(=O)[C@H](C)N(c2cccnc2C)C1=O ### Response: 0
functional_group
### Instruction: Does the molecule contain a sulfonyl group? CC[C@H](C)[C@@H](CO)c1ccccc1C ### Response: No
functional_group
### Instruction: Does the molecule contain a amide group? CCC[NH+]1CCC(NC(=O)c2c(C)nn(CCCl)c2C)CC1 ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. C1CC[NH2+][C@H](C[C@H](O)c2ccc(OC)cc2)C1 ### Response: COc1ccc([C@@H](O)C[C@@H]2CCCC[NH2+]2)cc1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CCOC(=O)/C(C#N)=C/c1ccc(-c2cc([N+](=O)[O-])ccc2OC)o1 ### Response: 1
functional_group
### Instruction: Does the molecule contain a amide group? CC[C@@H]1CC(=O)N(Cc2ccc(/C=C/C(=O)[O-])cc2)C1 ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. O=C(N1CCC[C@@H](C1)C(=O)NCCCC)C(C)(C)CC(C)C ### Response: CCCCNC(=O)[C@H]1CCCN(C(=O)C(C)(C)CC(C)C)C1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C(C[NH+]1CCS(=O)(=O)CC1)N/N=C/c1cccs1 ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. c1cc2c(cc1)n(CC(N1CCC(c3n(C)cnn3)CC1)=O)c(=O)o2 ### Response: Cn1cnnc1C1CCN(C(=O)Cn2c(=O)oc3ccccc32)CC1
functional_group
### Instruction: Does the molecule contain a thiol group? C[C@@H]1C[C@H](C)CN(C(=O)COC(=O)c2cccc(S(=O)(=O)N3CCc4ccccc43)c2)C1 ### Response: No
functional_group
### Instruction: Does the molecule contain a sulfonyl group? O=C(CCCc1c(-c2ccccn2)[nH]c2ccc(F)cc12)NNC(=O)c1ccc(Cl)cc1Cl ### Response: No
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)[C@@H]1O[C@H]2OC(C)(C)O[C@@H]2[C@H]2OC(C)(C)O[C@@H]21 Fragment 2: [5*]Nc1ccccc1SC ### Response: CSc1ccccc1NC(=O)[C@@H]1O[C@H]2OC(C)(C)O[C@@H]2[C@H]2OC(C)(C)O[C@@H]21
functional_group
### Instruction: Does the molecule contain a amide group? CCOc1cccc(NC(=O)/C(C#N)=C/c2cc(C)n(-c3ccccc3)c2C)c1 ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@@H](CN1CCN(c2ccccc2)CC1)NC(=O)Cc1cccc(F)c1F ### Response: 3
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCC[NH2+]Cc1cncc(N2CC[C@H](C)C2)n1 ### Response: 3
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCN(CCO)c1ncnc2c1sc1nc(CC(C)C)c3c(c12)CC(C)(C)OC3 ### Response: 3
functional_group
### Instruction: Does the molecule contain a ether group? CCOc1ccccc1NC(=O)c1cc(S(=O)(=O)N2CCN(c3cccc[nH+]3)CC2)ccc1F ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C=CCN(C(=O)Cc1csc(-c2ccccc2Cl)n1)[C@H]1CCS(=O)(=O)C1 ### Response: 3
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N1/C(=N/C(=O)CCC(=O)[O-])S[C@H]2CS(=O)(=O)C[C@@H]21 Fragment 2: [16*]c1ccc2c(c1)OCO2 ### Response: O=C([O-])CCC(=O)/N=C1\S[C@H]2CS(=O)(=O)C[C@@H]2N1c1ccc2c(c1)OCO2
functional_group
### Instruction: Does the molecule contain a nitrile group? CC(C)(C)N1C[C@@H](C(=O)N2CCC(C(=O)N(CC#N)CC#N)CC2)CC1=O ### Response: Yes
ring_counting
### Instruction: Count the six-membered rings in the following molecule. O=C(Cc1ccccc1F)NNC(=O)[C@@H]1CC(=O)N(Cc2ccccn2)C1 ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cn1c(=O)c2nc(C[NH+]3CCC[C@H]3CC(C)(C)C)[nH]c2n(C)c1=O ### Response: 3
ring_counting
### Instruction: Count the five-membered rings in the following molecule. C[NH+]1CCC(Nc2ccc3c(c2)CCN3S(C)(=O)=O)CC1 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. O=C(C1CCN(CC1)C(c1nc2c(cc1)cccc2)=O)N1CCCCCC1 ### Response: O=C(c1ccc2ccccc2n1)N1CCC(C(=O)N2CCCCCC2)CC1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [16*]c1ccc2ccccc2c1 Fragment 2: [4*]Cc1ccccc1 ### Response: O=C(Cc1ccc2ccccc2c1)N(Cc1ccccc1)[C@H]1CCS(=O)(=O)C1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. O=C1[C@H](NCc2nnc3n2CCCC3)CCN1c1ccccc1F ### Response: 2
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CCSc1nc2c(c(=O)[nH]c(=O)n2C)n1CC ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. CC(C)(OC(N[C@H](C(N[C@@H]1CCc2c(Br)cccc21)=O)c1ccccc1)=O)C ### Response: CC(C)(C)OC(=O)N[C@H](C(=O)N[C@@H]1CCc2c(Br)cccc21)c1ccccc1
functional_group
### Instruction: Does the molecule contain a nitro group? Cc1cc(C[NH+]2CCC(c3cnn(C)c3)CC2)ccc1Oc1cccnc1 ### Response: No
ring_counting
### Instruction: Count the five-membered rings in the following molecule. C[C@@H](C(=O)N(C)CC(=O)Nc1ccc([S@@](C)=O)cc1)n1cccn1 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C(Nc1ccccc1C[NH+]1CCSCC1)[C@@H]1C[C@H]1[N+](=O)[O-] ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C#Cc1cccc(N(CC(=O)NC)C(=O)c2ccco2)c1 ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CSC[C@H](C)NC(=O)Nc1ccc(C)c(F)c1 ### Response: 3
functional_group
### Instruction: Does the molecule contain a ether group? Nc1cc(F)c(O[C@H]2CCO[C@@]3(CCOC3)C2)cc1F ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCN(Cc1ccccc1)C(=O)CN(C)S(=O)(=O)c1ccc2c(c1)CCCC(=O)N2 ### Response: 2
ring_counting
### Instruction: Count the six-membered rings in the following molecule. COC(=O)c1ccc(CN(C)C(=O)Nc2cc(C#N)ccc2Cl)cc1 ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCOc1cccc2sc(NC(=O)c3cccc(C)c3)nc12 ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC[C@H](C)NC(=O)c1ccccc1C ### Response: 4
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N1CCCC1 Fragment 2: [1*]C(=O)c1cccc(S([12*])(=O)=O)c1 ### Response: CCCc1nnc(NC(=O)c2cccc(S(=O)(=O)N3CCCC3)c2)s1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CN(C)C(=O)[C@@H]1CCCN1C(=O)Cn1ccccc1=O ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1cnc(cc1C(=O)N1CCOc2cc(F)ccc12)OC1CCC1 ### Response: O=C(c1ccnc(OC2CCC2)c1)N1CCOc2cc(F)ccc21
canonicalization
### Instruction: Canonicalize the following SMILES string. N1(CCSCC1)c1c(cc(cc1)NC(=O)c1ccc(C(=O)N)cc1)Cl ### Response: NC(=O)c1ccc(C(=O)Nc2ccc(N3CCSCC3)c(Cl)c2)cc1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@@H]([NH2+]Cc1cn(-c2ccccc2)nn1)c1ccc(N2CCCCCC2)cc1 ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1ccc(-c2ccc(=O)[nH]n2)cc1S(=O)(=O)N(Cc1ccco1)C[C@H]1CCCO1 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@@H]1C[C@H](NC(=O)Cc2ccccc2Cl)CN1c1ccccc1 ### Response: 2
functional_group
### Instruction: Does the molecule contain a amide group? C[NH+](C)C1CCN(c2ccc(NC(=O)CCCn3ccnn3)cc2F)CC1 ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. N1(C(CSC1)=O)CC(NC1CCCCC1)=O ### Response: O=C(CN1CSCC1=O)NC1CCCCC1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CC(C)[NH+]1CCN(CC(=O)Nc2ccccc2Br)CC1 ### Response: 0
canonicalization
### Instruction: Canonicalize the following SMILES string. O(C)c1c(OC)c2C(O[C@@H]([C@H]3c4cc5c(cc4CCN3C)OCO5)c2cc1)=O ### Response: COc1ccc2c(c1OC)C(=O)O[C@H]2[C@H]1c2cc3c(cc2CCN1C)OCO3
functional_group
### Instruction: Does the molecule contain a halide group? O=C(Nc1ccc(C(=O)OC[C@@H]2CCC[NH+]3CCCC[C@@H]23)cc1)c1ccc([N+](=O)[O-])cc1 ### Response: No
ring_counting
### Instruction: Count the six-membered rings in the following molecule. NC(=O)CN1C(=O)/C(=C2/SC(=S)N(C3CCCCC3)C2=O)c2ccccc21 ### Response: 2
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CC[NH2+][C@@H](Cc1cccs1)[C@H]1CCC[C@H](S(C)(=O)=O)C1 ### Response: 1
functional_group
### Instruction: Does the molecule contain a amide group? CC(=O)Oc1ccc(C(=O)NNC(=O)c2cccnc2)cc1 ### Response: Yes
functional_group
### Instruction: Does the molecule contain a amide group? O=C(Cc1cccs1)N[C@@H](c1ccc(Cl)cc1)C1CC1 ### Response: Yes
functional_group
### Instruction: Does the molecule contain a amide group? O=C(NCc1cc2ccccc2o1)Nc1cccnc1 ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. O=C(Nn1cnc2n(C(C)(C)C)ncc2c1=O)CC1CCCCC1 ### Response: CC(C)(C)n1ncc2c(=O)n(NC(=O)CC3CCCCC3)cnc21
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cn1c(=O)c2cc(C(=O)N[C@H]3CCOc4ccccc43)cnc2n(C)c1=O ### Response: 1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Cn1cccc1C(=O)NC(=O)CSc1nc(C2CC2)n(-c2ccccc2)n1 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [8*][C@H](Cl)c1ccc(OC)c(Cl)c1 Fragment 2: [16*]c1ccc(OC)c(Cl)c1 ### Response: COc1ccc([C@@H](Cl)[C@@]2(C)CCCO2)cc1Cl
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*][NH+]1CC[C@@H]([15*])C1 Fragment 2: [8*]CC(C)C ### Response: CC(C)CNC(=O)[C@H](C)[NH+]1CC[C@@H](CC(C)C)C1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(n(CCCNC(C[C@H](C)c2ccccc2C)=O)cccc1)=O ### Response: Cc1ccccc1[C@@H](C)CC(=O)NCCCn1ccccc1=O
canonicalization
### Instruction: Canonicalize the following SMILES string. C(NC1COC1)(c1ccc(N)cc1)=O ### Response: Nc1ccc(C(=O)NC2COC2)cc1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]NCc1ccc(C)cc1 Fragment 2: [10*]N1C(=O)c2ccc(C)cc2C1=O ### Response: Cc1ccc(CNC(=O)CCCN2C(=O)c3ccc(C)cc3C2=O)cc1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. COc1cccc(C[NH2+]CC(C)(C)S(C)(=O)=O)c1O ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC(C)CC[C@@H]1CCC[C@H]1NC(=O)c1c[nH]c2ccccc2c1=O ### Response: 4
functional_group
### Instruction: Does the molecule contain a thiol group? C[C@H]1C(=O)N(c2ccccc2Cl)CCN1C(=O)C1CC1 ### Response: No
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1oc(C)c([C@@H]([NH3+])c2ccc(Br)c3ccccc23)c1C ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCC[NH+](C)C[C@H]1CCN(C(=O)c2ccnc(OC(C)(C)C)c2)C1 ### Response: 3
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*][NH2+]CC1([15*])CCCCC1 Fragment 2: [4*]CC1([15*])CCCCC1 ### Response: C[C@@H]([NH2+]CC1(CCO)CCCCC1)c1cccnc1
canonicalization
### Instruction: Canonicalize the following SMILES string. c12cccn2CCN(C(=O)c2ccncc2)[C@H]1c1ccccc1 ### Response: O=C(c1ccncc1)N1CCn2cccc2[C@@H]1c1ccccc1
functional_group
### Instruction: Does the molecule contain a ester group? O=C(Cn1cccc(C(F)(F)F)c1=O)N1CCC[C@@H]2CCCC[C@@H]21 ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. Cn1c(CC[NH2+][C@H]2[C@H](CCCC2)[C@H]2[NH2+]CCC2)nnc1 ### Response: Cn1cnnc1CC[NH2+][C@@H]1CCCC[C@@H]1[C@@H]1CCC[NH2+]1
canonicalization
### Instruction: Canonicalize the following SMILES string. C(CCC(N1CCC[C@H]2[C@H]1CC[C@@H](C2)C)=O)c1ccccn1 ### Response: C[C@H]1CC[C@@H]2[C@H](CCCN2C(=O)CCCc2ccccn2)C1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)c1c(N)n([9*])c2nc3ccccc3nc12 Fragment 2: [5*]NCCCC ### Response: CCCCNC(=O)c1c(N)n(-c2ccc(Br)cc2)c2nc3ccccc3nc12
canonicalization
### Instruction: Canonicalize the following SMILES string. c1c(OCC)c(NC(=O)CN2c3c(O[C@H](C2)C)ccc(Cl)c3)ccc1 ### Response: CCOc1ccccc1NC(=O)CN1C[C@H](C)Oc2ccc(Cl)cc21
canonicalization
### Instruction: Canonicalize the following SMILES string. O=C1[C@H](CC(=O)Nc2ccc(cc2)F)n2nc(CC)c(-c3ccc(cc3)Cl)c2N1 ### Response: CCc1nn2c(c1-c1ccc(Cl)cc1)NC(=O)[C@@H]2CC(=O)Nc1ccc(F)cc1
functional_group
### Instruction: Does the molecule contain a ether group? C[C@@H](C(=O)NCc1ccccc1F)C1CCN(C(=O)c2ccc3nc(-c4ccccc4)oc3c2)CC1 ### Response: No